caffeine has been researched along with Teeth, Impacted in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Förderreuther, S | 1 |
| Lampert, A | 1 |
| Hitier, S | 1 |
| Lange, R | 1 |
| Weiser, T | 1 |
| Borel, JF | 1 |
| Deschaumes, C | 1 |
| Devoize, L | 1 |
| Huard, C | 1 |
| Orliaguet, T | 1 |
| Dubray, C | 1 |
| Baudet-Pommel, M | 1 |
| Dallel, R | 1 |
| Hellem, S | 1 |
| Persson, G | 1 |
| Freiberg, N | 1 |
| Nord, PG | 1 |
| Gustafsson, B | 1 |
| Huitfeldt, B | 1 |
| Lyall, JB | 1 |
| Habib, S | 1 |
| Matthews, RW | 1 |
| Scully, C | 1 |
| Levers, BG | 1 |
| Shepherd, JP | 1 |
| Dupuis, R | 1 |
| Lemay, H | 1 |
| Bushnell, MC | 1 |
| Duncan, GH | 1 |
| Popkes, DL | 1 |
| Folsom, TC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single-centre, Double-blind, Randomised, Two-stage, Parallel-group Study to Assess the Efficacy and Safety of the Fixed Dose Combination of Ibuprofen 400 mg and Caffeine 100 mg Versus Ibuprofen 400 mg, Caffeine 100 mg and Placebo in Patients With Postop[NCT01929031] | Phase 3 | 562 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Duration of pain relief was defined as the time between the administration of first dose of trial medication and first dose of rescue medication or second dose of trial medication, whichever was first. Duration of pain relief was censored at 8 hours. (NCT01929031)
Timeframe: 8 hours
| Intervention | hours (Median) |
|---|---|
| Placebo | 1.63 |
| Caffeine | 2.08 |
| Ibuprofen | 7.11 |
| Ibuprofen/Caffeine | 7.33 |
Time to meaningful pain relief was captured by a stopwatch, which was started by the study staff immediately after the administration of the first dose of trial medication and which was to be stopped by the patient as soon as he/she felt meaningful pain relief. Time to meaningful pain relief was censored at 8 hours. (NCT01929031)
Timeframe: 8 hours
| Intervention | hours (Median) |
|---|---|
| Placebo | NA |
| Caffeine | NA |
| Ibuprofen | 1.78 |
| Ibuprofen/Caffeine | 1.13 |
SPRID0-2h: Time-weighted sum of PAR and PID from 0 to 2 hours, score range: -10 (worst) to 28 (best). PI was assessed on a 0-10 numerical pain rating scale (NPRS), where 0=no pain and 10=worst possible pain, pre-dose and at 0.25,0.5,0.75,1,1.5 and 2 hours; PAR was assessed on a 5-point verbal rating scale (VRS) (0=none to 4=complete) at the same post-dose time points. Time-weights were equal to the elapsed time (hour) between the time point of interest and the preceding time point. All PAR and pain intensity (PI) assessments completed after the patient had taken rescue medication or the second dose of study medication, whichever was first, until hour 2 was considered missing. Last observation carried forward (LOCF) was used with the last completed PI/PAR assessments prior to first rescue/second study medication, whichever was first, to impute missing values up to 2 hours. (NCT01929031)
Timeframe: 0 to 2 hours
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | 2.059 |
| Caffeine | 2.612 |
| Ibuprofen | 6.990 |
| Ibuprofen/Caffeine | 10.584 |
SPRID0-8h: Time-weighted sum of PAR and PID from 0 to 8 hours, score range: -40 (worst) to 112 (best). PI was assessed on a 0-10 numerical pain rating scale (NPRS), where 0=no pain and 10=worst possible pain, pre-dose and at 0.25,0.5,0.75,1,1.5,2,3,4,5, 6,7 and 8 hours; PAR was assessed on a 5-point verbal rating scale (VRS) (0=none to 4=complete) at the same post-dose time points. Time-weights were equal to the elapsed time (hour) between the time point of interest and the preceding time point. All PAR and pain intensity (PI) assessments completed after the patient had taken rescue medication or the second dose of study medication, whichever was first, until hour 8 were considered missing. Last observation carried forward (LOCF) was used with the last completed PI/PAR assessments prior to first rescue/second study medication, whichever was first, to impute missing values up to 8 hours. (NCT01929031)
Timeframe: 0 to 8 hours
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | 10.554 |
| Caffeine | 15.824 |
| Ibuprofen | 40.165 |
| Ibuprofen/Caffeine | 52.291 |
6 trials available for caffeine and Teeth, Impacted
| Article | Year |
|---|---|
The Impact of Baseline Pain Intensity on the Analgesic Efficacy of Ibuprofen/Caffeine in Patients with Acute Postoperative Dental Pain: Post Hoc Subgroup Analysis of a Randomised Controlled Trial.
Topics: Acute Pain; Adolescent; Adult; Analgesics; Caffeine; Dose-Response Relationship, Drug; Double-Blind | 2020 |
[Treating pain after dental surgery: a randomised, controlled, double-blind trial to assess a new formulation of paracetamol, opium powder and caffeine versus tramadol or placebo].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Caffeine; Central Nervous System Stimul | 2010 |
A model for evaluating the analgesic effect of a new fixed ratio combination analgesic in patients undergoing oral surgery.
Topics: Adult; Analgesics; Antipyrine; Aspirin; Caffeine; Dextropropoxyphene; Drug Combinations; Drug Evalua | 1979 |
Third molar surgery: the effect of primary closure, wound dressing and metronidazole on postoperative recovery.
Topics: Acetaminophen; Adult; Analgesics; Bandages; Bismuth; Caffeine; Codeine; Drug Combinations; Female; H | 1991 |
A study of the comparative efficacy of four common analgesics in the control of postsurgical dental pain.
Topics: Acetaminophen; Adult; Analgesics; Analysis of Variance; Aspirin; Caffeine; Codeine; Drug Combination | 1990 |
Preoperative flurbiprofen in oral surgery: a method of choice in controlling postoperative pain.
Topics: Adult; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Female; Flurbiprofen | 1988 |
1 other study available for caffeine and Teeth, Impacted
| Article | Year |
|---|---|
Comparative study of three analgesic agents used in oral surgical procedures.
Topics: Adolescent; Adult; Aged; Alveoloplasty; Analgesics; Aspirin; Caffeine; Codeine; Humans; Middle Aged; | 1969 |