caffeine has been researched along with Substance Withdrawal Syndrome in 261 studies
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
Excerpt | Relevance | Reference |
---|---|---|
"The effect of phased caffeine withdrawal and abstention on tinnitus severity was assessed using a pseudo-randomized, double-blinded, placebo-controlled crossover trial of 30 days duration." | 9.14 | Caffeine abstinence: an ineffective and potentially distressing tinnitus therapy. ( Claire, LS; McKenna, L; Rogers, PJ; Stothart, G, 2010) |
"Interruption of daily caffeine consumption can cause caffeine withdrawal headache." | 9.08 | Perioperative administration of caffeine tablets for prevention of postoperative headaches. ( Drewe, J; Hampl, KF; Rüttimann, U; Schneider, MC; Ummenhofer, W, 1995) |
"Maternal use of "social drugs" such as caffeine, ethanol and tobacco in pregnancy is on increase- -worldwide." | 8.85 | Peripartum implications of caffeine intake in pregnancy: is there cause for concern? ( Kuczkowski, KM, 2009) |
"Daily caffeine intake/kg body weight and caffeine use disorder are significantly associated with a caffeine-withdrawal headache." | 8.31 | Prevalence, characteristics, and factors associated with caffeine-withdrawal headache during the first day of Ramadan. ( Al-Azayem, SA; El Desouky, ED; Fathy, W; Hammad, EM; Hussein, M; Magdy, R; Mahfouz, NA; Naguib, EM; Salem, MR, 2023) |
"To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 7.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
"The purpose of the study was to examine whether caffeine dependence and a family history of alcoholism are associated with continued use of caffeine during pregnancy." | 7.73 | Caffeine dependence in combination with a family history of alcoholism as a predictor of continued use of caffeine during pregnancy. ( Berger, N; Griffiths, RR; Haug, NA; Svikis, DS, 2005) |
"In connection with the Vågå study of headache epidemiology, a search was made for caffeine-withdrawal headache in 1741 parishioners." | 7.72 | Caffeine-withdrawal headache. The Vågå study of headache epidemiology. ( Bakketeig, LS; Sjaastad, O, 2004) |
"It is believed that adenosine is released in ischemic tissues and contributes to reactive hyperemia." | 7.70 | Intravascular source of adenosine during forearm ischemia in humans: implications for reactive hyperemia. ( Angel, M; Biaggioni, I; Cavalcante, J; Christman, B; Costa, F; Haile, V; Sulur, P, 1999) |
"The extent to which daily caffeine use is associated with a substance dependence syndrome similar to that associated with other psychoactive drugs is unknown." | 7.69 | Caffeine dependence syndrome. Evidence from case histories and experimental evaluations. ( Griffiths, RR; Mumford, GK; Silverman, K; Strain, EC, 1994) |
"Caffeine consumption may cause headache, particularly migraine." | 7.69 | Influence of caffeine and caffeine withdrawal on headache and cerebral blood flow velocities. ( Couturier, EG; Laman, DM; van Duijn, H; van Duijn, MA, 1997) |
"The interruption of daily consumption of caffeine-containing beverages can cause headache and other symptoms within 8 hours." | 7.68 | Perioperative ingestion of caffeine and postoperative headache. ( Danielson, DR; Ereth, MH; Weber, JG, 1993) |
"This study examined the hypothesis that headache after general anesthesia is related to a caffeine withdrawal state." | 7.68 | Is caffeine withdrawal the mechanism of postoperative headache? ( Fennelly, M; Galletly, DC; Purdie, GI, 1991) |
"Lithium tremor worsened in two patients when caffeine (coffee) was eliminated from their diets." | 7.67 | Lithium tremor and caffeine intake: two cases of drinking less and shaking more. ( Jefferson, JW, 1988) |
"Plasma adenosine concentrations doubled when rats were subjected to 90 min of profound hemorrhagic shock." | 7.67 | Endogenous adenosine and hemorrhagic shock: effects of caffeine administration or caffeine withdrawal. ( Conlay, LA; Evoniuk, G; Wurtman, RJ, 1988) |
"A review of the recent literature shows the role of caffeine in the physiology, mood, and behavior of persons to be a complex one including changes in arousal, anxiety, and performance." | 7.66 | Caffeine and human behavior: arousal, anxiety, and performance effects. ( Julia, HL; Sawyer, DA; Turin, AC, 1982) |
"The effects of caffeine on specific mental illnesses and the medications used to treat them will be discussed." | 6.39 | Caffeine and its effect on persons with mental disorders. ( Simmons, DH, 1996) |
"Caffeine was administrated during all prenatal and postnatal life (CAF, 0." | 5.51 | Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence. ( Abreu-Villaça, Y; da Silva Gonçalves, B; Filgueiras, CC; Leal-Rocha, PH; Manhães, AC; Ribeiro-Carvalho, A, 2019) |
"We assessed the seizure vulnerability and anxiety responses following the chronic co-administration of, and withdrawal from, caffeine and ethanol in male rats." | 5.48 | Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model. ( Alele, PE; Matovu, D, 2018) |
"Caffeine was injected at doses of 80 mg/kg daily for five days." | 5.29 | 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. ( Haleem, DJ; Haleem, MA; Yasmeen, A; Zafar, A, 1995) |
"While caffeine benefits motor performance and tolerance develops to its tendency to increase anxiety/jitteriness, tolerance to its effects on sleepiness means that frequent consumption fails to enhance mental alertness and mental performance." | 5.17 | Faster but not smarter: effects of caffeine and caffeine withdrawal on alertness and performance. ( Heatherley, SV; Mullings, EL; Rogers, PJ; Smith, JE, 2013) |
"The effect of phased caffeine withdrawal and abstention on tinnitus severity was assessed using a pseudo-randomized, double-blinded, placebo-controlled crossover trial of 30 days duration." | 5.14 | Caffeine abstinence: an ineffective and potentially distressing tinnitus therapy. ( Claire, LS; McKenna, L; Rogers, PJ; Stothart, G, 2010) |
"Interruption of daily caffeine consumption can cause caffeine withdrawal headache." | 5.08 | Perioperative administration of caffeine tablets for prevention of postoperative headaches. ( Drewe, J; Hampl, KF; Rüttimann, U; Schneider, MC; Ummenhofer, W, 1995) |
"To determine whether prophylactic intravenous administration of caffeine, to daily caffeine users, decreases the frequency of postoperative headache and shortens recovery time." | 5.08 | Prophylactic intravenous administration of caffeine and recovery after ambulatory surgical procedures. ( Arnold, JJ; Danielson, DR; Ereth, MH; Klindworth, JT; Weber, JG, 1997) |
"This report evaluates the scientific literature on caffeine with respect to potential central nervous system (CNS) effects, specifically effects on sleep, anxiety, and aggression/risk-taking." | 4.93 | Neurobehavioral hazard identification and characterization for caffeine. ( Mariano, GF; Rodricks, JV; Turnbull, D, 2016) |
"We considered only English-language articles published in scientific journals and searched for these articles on PubMed using "headache," "fasting," "Yom Kippur," "Ramadan," "hypoglycemia,"and "caffeine withdrawal" as key words, with no limitations to the year of publication." | 4.85 | Fasting headache: a review of the literature and new hypotheses. ( Bini, A; Castellini, P; Evangelista, A; Lambru, G; Manzoni, GC; Torelli, P, 2009) |
"Maternal use of "social drugs" such as caffeine, ethanol and tobacco in pregnancy is on increase- -worldwide." | 4.85 | Peripartum implications of caffeine intake in pregnancy: is there cause for concern? ( Kuczkowski, KM, 2009) |
"Chronic, heavy caffeine ingestion may cause or exacerbate anxiety and may be associated with depression and increased use of antianxiety drugs." | 4.77 | Psychotropic effects of caffeine. ( Clementz, GL; Dailey, JW, 1988) |
"Daily caffeine intake/kg body weight and caffeine use disorder are significantly associated with a caffeine-withdrawal headache." | 4.31 | Prevalence, characteristics, and factors associated with caffeine-withdrawal headache during the first day of Ramadan. ( Al-Azayem, SA; El Desouky, ED; Fathy, W; Hammad, EM; Hussein, M; Magdy, R; Mahfouz, NA; Naguib, EM; Salem, MR, 2023) |
"Participants in the Told Caffeine condition reported a significantly greater reduction in the factors of cravings, fatigue, lack of alertness and flu-like feelings of the CWSQ, than those in the Told Decaf condition." | 3.83 | Placebo caffeine reduces withdrawal in abstinent coffee drinkers. ( Boakes, RA; Colagiuri, B; Mills, L, 2016) |
"Habitual caffeine consumers who abstain from caffeine experience withdrawal symptoms such as headache, fatigue, difficulty concentrating, mood disturbances, and flu-like symptoms (Juliano and Griffiths, 2004)." | 3.78 | Development of the caffeine withdrawal symptom questionnaire: caffeine withdrawal symptoms cluster into 7 factors. ( Harrell, PT; Huntley, ED; Juliano, LM; Westerman, AT, 2012) |
" Dipyridamole, a blocker of adenosine reuptake, induced a significant reduction of morphine dependence." | 3.75 | Functional interaction between purinergic system and opioid withdrawal: in vitro evidence. ( Capasso, A; Gallo, C, 2009) |
"To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 3.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
"The purpose of the study was to examine whether caffeine dependence and a family history of alcoholism are associated with continued use of caffeine during pregnancy." | 3.73 | Caffeine dependence in combination with a family history of alcoholism as a predictor of continued use of caffeine during pregnancy. ( Berger, N; Griffiths, RR; Haug, NA; Svikis, DS, 2005) |
"In connection with the Vågå study of headache epidemiology, a search was made for caffeine-withdrawal headache in 1741 parishioners." | 3.72 | Caffeine-withdrawal headache. The Vågå study of headache epidemiology. ( Bakketeig, LS; Sjaastad, O, 2004) |
"It is believed that adenosine is released in ischemic tissues and contributes to reactive hyperemia." | 3.70 | Intravascular source of adenosine during forearm ischemia in humans: implications for reactive hyperemia. ( Angel, M; Biaggioni, I; Cavalcante, J; Christman, B; Costa, F; Haile, V; Sulur, P, 1999) |
"The extent to which daily caffeine use is associated with a substance dependence syndrome similar to that associated with other psychoactive drugs is unknown." | 3.69 | Caffeine dependence syndrome. Evidence from case histories and experimental evaluations. ( Griffiths, RR; Mumford, GK; Silverman, K; Strain, EC, 1994) |
"By the example of two case reports, typical signs of caffeine withdrawal like headache, increased irritability, decreased performance and disturbed concentration are described." | 3.69 | [Episodic headache, diminished performance and depressive mood]. ( Cacciatore, R; Helbling, A; Hess, B; Jost, C, 1996) |
"Caffeine consumption may cause headache, particularly migraine." | 3.69 | Influence of caffeine and caffeine withdrawal on headache and cerebral blood flow velocities. ( Couturier, EG; Laman, DM; van Duijn, H; van Duijn, MA, 1997) |
"The interruption of daily consumption of caffeine-containing beverages can cause headache and other symptoms within 8 hours." | 3.68 | Perioperative ingestion of caffeine and postoperative headache. ( Danielson, DR; Ereth, MH; Weber, JG, 1993) |
"This study examined the hypothesis that headache after general anesthesia is related to a caffeine withdrawal state." | 3.68 | Is caffeine withdrawal the mechanism of postoperative headache? ( Fennelly, M; Galletly, DC; Purdie, GI, 1991) |
"Lithium tremor worsened in two patients when caffeine (coffee) was eliminated from their diets." | 3.67 | Lithium tremor and caffeine intake: two cases of drinking less and shaking more. ( Jefferson, JW, 1988) |
"Plasma adenosine concentrations doubled when rats were subjected to 90 min of profound hemorrhagic shock." | 3.67 | Endogenous adenosine and hemorrhagic shock: effects of caffeine administration or caffeine withdrawal. ( Conlay, LA; Evoniuk, G; Wurtman, RJ, 1988) |
"A review of the recent literature shows the role of caffeine in the physiology, mood, and behavior of persons to be a complex one including changes in arousal, anxiety, and performance." | 3.66 | Caffeine and human behavior: arousal, anxiety, and performance effects. ( Julia, HL; Sawyer, DA; Turin, AC, 1982) |
"decaf) can reduce caffeine withdrawal symptoms, even when people do not hold a conscious expectancy it will do so." | 3.30 | Reduction in caffeine withdrawal after open-label decaffeinated coffee. ( Boakes, R; Colagiuri, B; Lee, JC; Mills, L, 2023) |
"Caffeine did not increase alertness in NL participants." | 2.75 | Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption. ( Deckert, J; Evershed, RP; Heatherley, SV; Hohoff, C; Maxfield, PJ; Mullings, EL; Nutt, DJ; Rogers, PJ, 2010) |
"Caffeine dose was crossed with varying instructions that the coffee would either enhance or impair performance in a 2 x 2 factorial design." | 2.74 | Caffeine expectancies influence the subjective and behavioral effects of caffeine. ( Harrell, PT; Juliano, LM, 2009) |
"Caffeine was found to have few and modest effects on EEG in the theta and alpha bandwidths, and no effects in the delta and beta bandwidths." | 2.73 | Effects of dietary caffeine on topographic EEG after controlling for withdrawal and withdrawal reversal. ( Hogan, MJ; James, JE; Keane, MA, 2007) |
"Caffeine is a popular stimulant often used to counter the effects of sleep loss and fatigue." | 2.73 | Effects of acute caffeine withdrawal on Short Category Test performance in sleep-deprived individuals. ( Balkin, TJ; Kahn-Greene, ET; Kamimori, GH; Killgore, DB; Killgore, WD, 2007) |
"Caffeine deprivation was associated with impaired vigilance performance characterized by a reduction in the percentage of targets detected and an increase in response time, and by subjective reports of decreased vigor and increased fatigue and symptoms characterized by sleepiness, headache, and reduced ability to work." | 2.69 | Caffeine deprivation affects vigilance performance and mood. ( Lane, JD; Phillips-Bute, BG, 1998) |
"no caffeine) were administered double-blind in novel fruit juice drinks at 10:15, 11:30 and 13:00 h on the test day." | 2.69 | Mood and psychomotor performance effects of the first, but not of subsequent, cup-of-coffee equivalent doses of caffeine consumed after overnight caffeine abstinence. ( Robelin, M; Rogers, PJ, 1998) |
"A group of those reporting withdrawal symptoms were randomly assigned to three subsamples." | 2.69 | The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. ( Curtis, GL; Dews, PB; Hanford, KJ; O'Brien, CP, 1999) |
" Adverse events were negligible and did not differ between the CE and PL groups." | 2.69 | Safety and efficacy of treatment with an ephedrine/caffeine mixture. The first double-blind placebo-controlled pilot study in adolescents. ( Erhardt, E; Jeges, S; Molnár, D; Török, K, 2000) |
"Caffeine deprivation was manipulated by administering capsules containing 0%, 50%, or 100% of each subject's daily caffeine intake (complete, partial, and no deprivation conditions)." | 2.68 | Caffeine withdrawal symptoms and self-administration following caffeine deprivation. ( de Wit, H; Mitchell, SH; Zacny, JP, 1995) |
""Headache" was significantly correlated with amount of money forfeited to avoid placebo." | 2.68 | Caffeine reinforcement: the role of withdrawal. ( Griffiths, RR; Schuh, KJ, 1997) |
"Caffeine withdrawal was examined in caffeine-dependent humans living in a residential laboratory." | 2.68 | Effects of caffeine withdrawal on humans living in a residential laboratory. ( Comer, SD; Fischman, MW; Foltin, RW; Haney, M, 1997) |
"Caffeine deprivation was associated with decreased vigor and increased fatigue and with symptoms including sleepiness and yawning." | 2.68 | Caffeine withdrawal symptoms following brief caffeine deprivation. ( Lane, JD; Phillips-Bute, BG, 1997) |
"Twenty-two coffee drinkers (three to seven cups per day) underwent repeated double-blind trials to test for caffeine self-administration, withdrawal, and adverse effects." | 2.67 | Caffeine self-administration, withdrawal, and adverse effects among coffee drinkers. ( Bickel, WK; Fenwick, JW; Gulliver, SB; Higgins, ST; Hughes, JR; Hunt, WK; Mireault, GC, 1991) |
"As most of the population, including migraineurs, consume a considerable amount of caffeine daily, a question arises as to whether it influences their headaches." | 2.66 | The Ambiguous Role of Caffeine in Migraine Headache: From Trigger to Treatment. ( Kaźmierczak, W; Nowaczewska, M; Wiciński, M, 2020) |
"Caffeine has a synergistic effectiveness with analgesics." | 2.41 | Do caffeine-containing analgesics promote dependence? A review and evaluation. ( Dalessio, D; Feinstein, AR; Fox, JM; Goldstein, J; Haag, G; Heinemann, LA; Ladewig, D; O'Brien, CP, 2000) |
"Caffeine is an excellent model compound for understanding drugs of abuse/dependence." | 2.41 | Caffeine as a model drug of dependence: recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome, and caffeine negative reinforcement. ( Chausmer, AL; Griffiths, RR, 2000) |
"There is evidence for caffeine withdrawal symptoms, and caffeine does act as a weak reinforcer, but neither effect is as pronounced as those associated with cocaine." | 2.40 | [Is caffeine addictive? The most widely used psychoactive substance in the world affects same parts of the brain as cocaine]. ( Daly, JW; Fredholm, BB; Holmén, J, 1998) |
"The effects of caffeine on specific mental illnesses and the medications used to treat them will be discussed." | 2.39 | Caffeine and its effect on persons with mental disorders. ( Simmons, DH, 1996) |
"Withdrawal symptoms have been documented after relatively short-term exposure to high doses of caffeine (i." | 2.37 | Caffeine physical dependence: a review of human and laboratory animal studies. ( Griffiths, RR; Woodson, PP, 1988) |
"Caffeine expectancy was associated with reduced subjective withdrawal 30 min following the gum administration but was not significantly impacted by actual caffeine administration." | 1.72 | The impacts of caffeine administration, expectancies, and related stimuli on coffee craving, withdrawal, and self-administration. ( Barrett, SP; Shephard, A, 2022) |
" Dose-response testing indicated an optimal caffeine concentration of 0." | 1.56 | Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior. ( George, O; Kimbrough, A; Lee, CH, 2020) |
"We found 16 categories of withdrawal symptoms." | 1.56 | Mechanisms for the reduction of caffeine consumption: What, how and why. ( Booth, N; Chung, A; McKean, J; Park, JJ; Rodda, S; Ware, P, 2020) |
"Whether acute exercise can reduce withdrawal symptoms also remains unknown." | 1.51 | Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal. ( Fagan, MJ; Morava, A; Prapavessis, H, 2019) |
"Negative expectancies can exacerbate withdrawal symptoms via the nocebo effect." | 1.51 | The effect of dose expectancies on caffeine withdrawal symptoms during tapered dose reduction. ( Boakes, RA; Colagiuri, B; Mills, L, 2019) |
"Caffeine was administrated during all prenatal and postnatal life (CAF, 0." | 1.51 | Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence. ( Abreu-Villaça, Y; da Silva Gonçalves, B; Filgueiras, CC; Leal-Rocha, PH; Manhães, AC; Ribeiro-Carvalho, A, 2019) |
"There were no expectancy effects on withdrawal symptoms or cognitive performance." | 1.51 | Investigating the role of expectancy in caffeine withdrawal using the balanced placebo design. ( Edwards, KC; Harrell, PT; Juliano, LM; Kardel, PG; Muench, C, 2019) |
"We assessed the seizure vulnerability and anxiety responses following the chronic co-administration of, and withdrawal from, caffeine and ethanol in male rats." | 1.48 | Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model. ( Alele, PE; Matovu, D, 2018) |
"Caffeine is a common psychoactive substance with a documented addictive potential." | 1.48 | Caffeine use disorder: An item-response theory analysis of proposed DSM-5 criteria. ( Ágoston, C; Demetrovics, Z; Richman, MJ; Urbán, R, 2018) |
"After 24-hour caffeine abstinence withdrawal symptoms were measured using a self-report caffeine withdrawal scale, and then again after a cup of decaffeinated coffee." | 1.46 | Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms. ( Colagiuri, B; Dar-Nimrod, I; Mills, L, 2017) |
"Caffeine abstinence was independently associated with an excellent efficacy of acute treatment (multivariate odds ratio, 3." | 1.43 | Caffeine discontinuation improves acute migraine treatment: a prospective clinic-based study. ( Choi, H; Choi, HA; Chung, CS; Lee, MJ, 2016) |
"Withdrawal of caffeine however produced memory deficits and significantly increases the immobility time of rats in FST." | 1.38 | Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats. ( Haider, S; Haleem, DJ; Khaliq, S; Naqvi, F; Perveen, T; Saleem, S, 2012) |
"Caffeine treatment seekers (mean age 41 years, 55% women) consumed an average of 548 mg caffeine per day." | 1.38 | Characterization of individuals seeking treatment for caffeine dependence. ( Evatt, DP; Griffiths, RR; Juliano, LM; Richards, BD, 2012) |
"GAD, phobias, and MDD shared genetic factors with caffeine use, with genetic correlations estimated to be 0." | 1.38 | Common psychiatric disorders and caffeine use, tolerance, and withdrawal: an examination of shared genetic and environmental effects. ( Bergin, JE; Kendler, KS, 2012) |
"Caffeine is a psychostimulant with intake through foods or beverages tending to increase from childhood through adolescence." | 1.37 | Acute and adaptive motor responses to caffeine in adolescent and adult rats. ( Huggler, AL; Rhoads, DE; Rhoads, LJ, 2011) |
"The patients suffering from eating disorders reported higher current caffeine intake than those with anxiety or mood disorders." | 1.36 | Patterns of caffeine consumption in psychiatric patients. An Italian study. ( Carmassi, C; Ciampa, G; Ciapparelli, A; Consoli, G; Dell'Osso, L; Marazziti, D; Paggini, R; Ramacciotti, CE; Taponecco, C, 2010) |
" Caffeine improved alerting and executive control function in a dose-response manner, asymptoting at 200mg; this effect is congruent with caffeine's adenosine-mediated effects on dopamine-rich areas of brain, and the involvement of these areas in alerting and the executive control of visual attention." | 1.36 | Caffeine modulates attention network function. ( Brunyé, TT; Lieberman, HR; Mahoney, CR; Taylor, HA, 2010) |
"The 14 withdrawal symptoms were grouped into three factors termed "fatigue and headache", "dysphoric mood", and "flu-like somatic"." | 1.35 | Fourteen well-described caffeine withdrawal symptoms factor into three clusters. ( Brenner, D; El-Sohemy, A; Ozsungur, S, 2009) |
"As for withdrawal symptoms, NCT caused a more intensive degree of irritability than CAF or ALC, and a more intensive degree of difficulty concentrating and restlessness than did withdrawal from ALC." | 1.35 | Psychosocial withdrawal characteristics of nicotine compared with alcohol and caffeine. ( Hironaka, N; Miyasato, K; Miyata, H; Nakamura, K; Takada, K; Yanagita, T, 2008) |
" Following this repeated caffeine doses were administered to test the claim that repeated dosing has no extra effect on mood or performance." | 1.34 | Effects of repeated doses of caffeine on performance and alertness: new data and secondary analyses. ( Hewlett, P; Smith, A, 2007) |
"Adenosine reduces opioid withdrawal symptoms by activating A(1) adenosine receptors, probably by inhibiting excitatory amino acid release." | 1.32 | Interactive role of adenosine and dopamine in the opiate withdrawal syndrome. ( Berrino, L; Capuano, A; De Novellis, V; Filippelli, A; Mazzeo, F; Rossi, F; Stella, L; Vitelli, MR, 2003) |
"Other substance dependence disorders were not overrepresented in the caffeine dependent group compared to the caffeine nondependent group." | 1.31 | Caffeine use and dependence in adolescents: one-year follow-up. ( Bernstein, GA; Oberstar, JV; Thuras, PD, 2002) |
"In a second model, hyperalgesia was induced by the i." | 1.31 | Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. ( Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C, 2002) |
"Eight expert substance abuse clinicians agreed with self-endorsed caffeine dependence 91% of the time." | 1.30 | Endorsement of DSM-IV dependence criteria among caffeine users. ( Carpenter, J; Howard, T; Hughes, JR; Liguori, A; Oliveto, AH, 1998) |
"Caffeine is an addictive psychoactive substance." | 1.30 | Caffeine intake, tolerance, and withdrawal in women: a population-based twin study. ( Kendler, KS; Prescott, CA, 1999) |
"Caffeine was injected at doses of 80 mg/kg daily for five days." | 1.29 | 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. ( Haleem, DJ; Haleem, MA; Yasmeen, A; Zafar, A, 1995) |
" Stimulatory effects of injected caffeine were lower in chronically treated mice and the biphasic dose-response (stimulatory followed by depressant) curve for injected caffeine was left shifted." | 1.29 | Locomotor activity in mice during chronic treatment with caffeine and withdrawal. ( Daly, JW; Jacobson, KA; Nikodijević, O, 1993) |
"Caffeine has recently undergone scrutiny as a co-morbid risk factor with other substance dependencies, and in other medical and psychiatric conditions." | 1.29 | Primary caffeine dependence: a case report. ( Adams, D; Ditzler, T; Haning, WF, 1993) |
"The males amongst these were all migraine patients, but 23% of the women suffered from tension-type headache." | 1.28 | Weekend attacks in migraine patients: caused by caffeine withdrawal? ( Couturier, EG; Hering, R; Steiner, TJ, 1992) |
"Caffeine did not increase the severity of symptoms but did decrease the severity of withdrawal-induced hunger." | 1.28 | Effects of caffeine on tobacco withdrawal. ( Bickel, WK; Fenwick, JW; Higgins, ST; Hughes, JR; Oliveto, AH; Pepper, SL; Terry, SY, 1991) |
"Mild caffeine deprivation was associated with symptoms of stress." | 1.28 | Cardiovascular reactivity, mood, and task performance in deprived and nondeprived coffee drinkers. ( Baum, A; O'Keeffe, MK; Ratliff-Crain, J, 1989) |
"Caffeine was contained in at least one drug in all cases, ergotamine in 80." | 1.28 | Longterm prognosis of analgesic withdrawal in patients with drug-induced headaches. ( Baumgartner, C; Bingöl, C; Holzner, F; Maly, J; Wessely, P, 1989) |
"Caffeine was found to be approximately 10X more active than Na benzoate in inhibiting cAMP phosphodiesterase activity in a neuroblastoma cell whole homogenate assay." | 1.26 | Caffeine elicited withdrawal signs in morphine-dependent rhesus monkeys. ( Aceto, MD; Carchman, RA; Flora, RE; Harris, LS, 1978) |
"Caffeine 'insomnia' thus seems characterized by increased stability of wakefulness, and hypnotic withdrawal 'insomnia' by decreased stability fo sleep." | 1.25 | Two types of insomnia: too much waking or not enough sleep. ( Brezinová, V; Loudon, J; Oswald, I, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 58 (22.22) | 18.7374 |
1990's | 92 (35.25) | 18.2507 |
2000's | 65 (24.90) | 29.6817 |
2010's | 35 (13.41) | 24.3611 |
2020's | 11 (4.21) | 2.80 |
Authors | Studies |
---|---|
Mills, L | 4 |
Lee, JC | 1 |
Boakes, R | 1 |
Colagiuri, B | 4 |
Lin, YS | 1 |
Weibel, J | 1 |
Landolt, HP | 1 |
Santini, F | 1 |
Slawik, H | 1 |
Borgwardt, S | 1 |
Cajochen, C | 1 |
Reichert, CF | 1 |
Magdy, R | 1 |
El Desouky, ED | 1 |
Hammad, EM | 1 |
Salem, MR | 1 |
Mahfouz, NA | 1 |
Fathy, W | 1 |
Al-Azayem, SA | 1 |
Naguib, EM | 1 |
Hussein, M | 1 |
Martin, EL | 1 |
Baker, NL | 1 |
Sempio, C | 1 |
Christians, U | 1 |
Klawitter, J | 1 |
McRae-Clark, AL | 1 |
Chattha, N | 1 |
Webb, T | 1 |
Hargroves, D | 1 |
Balogun, I | 1 |
Bertoni, M | 1 |
Morava, A | 1 |
Fagan, MJ | 1 |
Prapavessis, H | 1 |
Lee, CH | 1 |
George, O | 1 |
Kimbrough, A | 1 |
Rodda, S | 1 |
Booth, N | 1 |
McKean, J | 1 |
Chung, A | 2 |
Park, JJ | 1 |
Ware, P | 1 |
Nowaczewska, M | 1 |
Wiciński, M | 1 |
Kaźmierczak, W | 1 |
Bright, M | 1 |
Raman, V | 1 |
Laupland, KB | 1 |
Agritelley, MS | 1 |
Goldberger, JJ | 1 |
Evans, MJ | 1 |
Jenkins, MD | 1 |
Berry, JN | 1 |
Shephard, A | 1 |
Barrett, SP | 1 |
Kalladka, D | 1 |
Siddiqui, A | 1 |
Tyagi, A | 1 |
Newman, E | 1 |
Dar-Nimrod, I | 1 |
Matovu, D | 1 |
Alele, PE | 1 |
Ágoston, C | 1 |
Urbán, R | 1 |
Richman, MJ | 1 |
Demetrovics, Z | 1 |
Boakes, RA | 2 |
da Silva Gonçalves, B | 1 |
Leal-Rocha, PH | 1 |
Manhães, AC | 1 |
Filgueiras, CC | 1 |
Abreu-Villaça, Y | 1 |
Ribeiro-Carvalho, A | 1 |
Juliano, LM | 5 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Comparing the Acute Effects of Exercise and Caffeine on Working Memory During a Short Period of Caffeine Deprivation in Moderate to Heavy Caffeine Consumers[NCT05170464] | Phase 2/Phase 3 | 42 participants (Anticipated) | Interventional | 2022-01-31 | Not yet recruiting | ||
CaffeinICU Study - A Randomized Controlled Multi-centre Pilot Study, on the Efficacy of Oral Caffeine, in Reducing the Duration of Mechanical Ventilation in Critically Ill Adult Patients[NCT05232734] | Phase 2 | 30 participants (Anticipated) | Interventional | 2022-11-24 | Recruiting | ||
Impact of Intravenous Caffeine on Atrial Electrical Properties and Potential Arrythmia Induction in Patients With Paroxysmal Atrial Fibrillation: The COFFEE-AF Trial[NCT05464940] | 100 participants (Anticipated) | Interventional | 2023-06-30 | Not yet recruiting | |||
A Randomized, Double Dummy, Double Blind, Placebo Controlled Cross Over Study to Evaluate Efficacy of Investigational Product E-AG-01/ E-AG02/ E-AG-03/ E-AG-04 on Alertness and Mental Fatigue[NCT02816827] | 59 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
The Impact of Caffeine on Cognition in Schizophrenia[NCT02832401] | 24 participants (Actual) | Interventional | 2016-09-02 | Completed | |||
Weekend Headaches in School-age Children[NCT05218330] | 100 participants (Anticipated) | Observational | 2022-01-01 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
33 reviews available for caffeine and Substance Withdrawal Syndrome
Article | Year |
---|---|
The Ambiguous Role of Caffeine in Migraine Headache: From Trigger to Treatment.
Topics: Adolescent; Adult; Beverages; Caffeine; Child; Female; Humans; Male; Middle Aged; Migraine Disorders | 2020 |
Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review.
Topics: Anesthesia Recovery Period; Caffeine; Central Nervous System Stimulants; Critical Care; Headache; Hu | 2021 |
Caffeine supplementation in the hospital: Potential role for the treatment of caffeine withdrawal.
Topics: Administration, Oral; Caffeine; Dietary Supplements; Hospitals; Humans; Inpatients; Substance Withdr | 2021 |
Caffeine and cognitive performance: persistent methodological challenges in caffeine research.
Topics: Caffeine; Cognition; Humans; Substance Withdrawal Syndrome | 2014 |
The management of substance abuse in the critically ill.
Topics: Alcoholic Intoxication; Benzodiazepines; Caffeine; Cocaine-Related Disorders; Critical Illness; Drug | 2014 |
Neurobehavioral hazard identification and characterization for caffeine.
Topics: Aggression; Animals; Anxiety; Caffeine; Central Nervous System; Central Nervous System Stimulants; D | 2016 |
Caffeine and headaches.
Topics: Caffeine; Headache; Headache Disorders, Secondary; Humans; Substance Withdrawal Syndrome | 2008 |
Caffeinated energy drinks--a growing problem.
Topics: Advertising; Beverages; Caffeine; Central Nervous System Stimulants; Drug Tolerance; Humans; Legisla | 2009 |
Systematic review on the effectiveness of caffeine abstinence on the quality of sleep.
Topics: Adult; Caffeine; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Patient Complia | 2009 |
Fasting headache: a review of the literature and new hypotheses.
Topics: Caffeine; Causality; Fasting; Food Deprivation; Headache; Homeostasis; Humans; Hypoglycemia; Religio | 2009 |
Peripartum implications of caffeine intake in pregnancy: is there cause for concern?
Topics: Abnormalities, Drug-Induced; Adult; Animals; Beverages; Caffeine; Dose-Response Relationship, Drug; | 2009 |
Caffeine at high altitude: java at base cAMP.
Topics: Acclimatization; Altitude; Altitude Sickness; Beverages; Caffeine; Central Nervous System Stimulants | 2010 |
Caffeine withdrawal, sleepiness, and driving performance: what does the research really tell us?
Topics: Attention; Automobile Driving; Caffeine; Central Nervous System Stimulants; Humans; Narcolepsy; Reac | 2011 |
Caffeine: behavioral effects of withdrawal and related issues.
Topics: Behavior; Caffeine; Central Nervous System Stimulants; Drug Tolerance; Humans; Substance Withdrawal | 2002 |
A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features.
Topics: Caffeine; Diagnostic and Statistical Manual of Mental Disorders; Humans; Incidence; Meta-Analysis as | 2004 |
Effects of caffeine on performance and mood: withdrawal reversal is the most plausible explanation.
Topics: Affect; Arousal; Attention; Caffeine; Central Nervous System Stimulants; Drug Tolerance; Follow-Up S | 2005 |
Is caffeine addictive?--a review of the literature.
Topics: Caffeine; Drug Tolerance; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 2006 |
Caffeine and headaches.
Topics: Adenosine; Brain; Caffeine; Drug Combinations; Drug Synergism; Headache Disorders; Headache Disorder | 2007 |
Caffeine, sleep and wakefulness: implications of new understanding about withdrawal reversal.
Topics: Automobile Driving; Brain; Caffeine; Central Nervous System Stimulants; Electroencephalography; Huma | 2007 |
Caffeine.
Topics: Adult; Age Factors; Animals; Behavior, Animal; Birth Weight; Caffeine; Cardiovascular System; Centra | 1982 |
Caffeine dependence: fact or fiction?
Topics: Caffeine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Caffeine use: is there a net benefit for mood and psychomotor performance?
Topics: Affect; Animals; Caffeine; Humans; Psychomotor Performance; Substance Withdrawal Syndrome | 1995 |
Is caffeine involved in the pathogenesis of combat-stress reaction?
Topics: Caffeine; Central Nervous System Stimulants; Combat Disorders; Humans; Military Personnel; Stress, P | 1996 |
Caffeine and its effect on persons with mental disorders.
Topics: Caffeine; Humans; Mental Disorders; Neurocognitive Disorders; Neurologic Examination; Substance With | 1996 |
[Is caffeine addictive? The most widely used psychoactive substance in the world affects same parts of the brain as cocaine].
Topics: Adult; Animals; Brain; Caffeine; Central Nervous System Stimulants; Drug Interactions; Humans; Recep | 1998 |
Do caffeine-containing analgesics promote dependence? A review and evaluation.
Topics: Analgesics; Caffeine; Drug Synergism; Evidence-Based Medicine; Headache; Humans; Phenacetin; Substan | 2000 |
Caffeine as a model drug of dependence: recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome, and caffeine negative reinforcement.
Topics: Adolescent; Adult; Caffeine; Child; Humans; Models, Biological; Reinforcement, Psychology; Substance | 2000 |
Physiologic and psychotropic effects of caffeine on man. A review.
Topics: Adolescent; Adult; Age Factors; Aged; Attention Deficit Disorder with Hyperactivity; Cacao; Caffeine | 1977 |
Possible psychiatric significance of excessive coffee consumption.
Topics: Adult; Anxiety Disorders; Blood Pressure; Caffeine; Canada; Cardiovascular System; Cerebrovascular C | 1975 |
Should caffeine abuse, dependence, or withdrawal be added to DSM-IV and ICD-10?
Topics: Caffeine; Coffee; Humans; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Substance | 1992 |
Caffeine physical dependence: a review of human and laboratory animal studies.
Topics: Animals; Caffeine; Humans; Risk Factors; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Psychotropic effects of caffeine.
Topics: Affect; Anxiety; Behavior; Caffeine; Depression; Dose-Response Relationship, Drug; Female; Food Anal | 1988 |
Propoxyphene hydrochloride. A critical review.
Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headac | 1970 |
64 trials available for caffeine and Substance Withdrawal Syndrome
Article | Year |
---|---|
Reduction in caffeine withdrawal after open-label decaffeinated coffee.
Topics: Alcoholic Intoxication; Caffeine; Coffee; Humans; Psychotropic Drugs; Substance Withdrawal Syndrome; | 2023 |
Brain activity during a working memory task after daily caffeine intake and caffeine withdrawal: a randomized double-blind placebo-controlled trial.
Topics: Adult; Brain; Caffeine; Cerebral Cortex; Cross-Over Studies; Double-Blind Method; Humans; Memory, Sh | 2023 |
Effects of dietary caffeine on EEG, performance and mood when rested and sleep restricted.
Topics: Adolescent; Affect; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Diet; Electroen | 2008 |
Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects.
Topics: Adult; Anterior Cerebral Artery; Caffeine; Central Nervous System Stimulants; Cerebrovascular Circul | 2009 |
Caffeine expectancies influence the subjective and behavioral effects of caffeine.
Topics: Affect; Attention; Caffeine; Central Nervous System Stimulants; Coffee; Double-Blind Method; Female; | 2009 |
Caffeine abstinence: an ineffective and potentially distressing tinnitus therapy.
Topics: Adult; Aged; Caffeine; Central Nervous System Stimulants; Coffee; Cross-Over Studies; Double-Blind M | 2010 |
Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.
Topics: Adult; Anxiety; Arousal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Dr | 2010 |
Acute effects of caffeine on attention: a comparison of non-consumers and withdrawn consumers.
Topics: Adolescent; Adult; Attention; Beverages; Caffeine; Cognition; Double-Blind Method; Female; Humans; M | 2013 |
Faster but not smarter: effects of caffeine and caffeine withdrawal on alertness and performance.
Topics: Adolescent; Adult; Anxiety; Caffeine; Central Nervous System Stimulants; Cognition; Computers; Dose- | 2013 |
Oral caffeine maintenance potentiates the reinforcing and stimulant subjective effects of intravenous nicotine in cigarette smokers.
Topics: Administration, Oral; Adult; Caffeine; Central Nervous System Stimulants; Cocaine-Related Disorders; | 2003 |
Topographic quantitative EEG response to acute caffeine withdrawal: a comprehensive analysis of multiple quantitative variables.
Topics: Adolescent; Adult; Alpha Rhythm; Analysis of Variance; Beta Rhythm; Brain Mapping; Caffeine; Cerebra | 2002 |
Attenuated adrenocortical and blood pressure responses to psychological stress in ad libitum and abstinent smokers.
Topics: Adrenal Cortex; Adult; Affect; Blood Pressure; Caffeine; Central Nervous System Stimulants; Cotinine | 2003 |
Transdermal nicotine maintenance attenuates the subjective and reinforcing effects of intravenous nicotine, but not cocaine or caffeine, in cigarette-smoking stimulant abusers.
Topics: Administration, Cutaneous; Adult; Blood Pressure; Caffeine; Central Nervous System Stimulants; Cocai | 2004 |
Effects of dietary caffeine on mood when rested and sleep restricted.
Topics: Adolescent; Adult; Affect; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Diet; Do | 2004 |
How habitual caffeine consumption and dose influence flavour preference conditioning with caffeine.
Topics: Adult; Association Learning; Caffeine; Central Nervous System Stimulants; Choice Behavior; Condition | 2004 |
Effects of caffeine in non-withdrawn volunteers.
Topics: Activity Cycles; Adult; Affect; Attention; Caffeine; Drug Administration Schedule; Human Experimenta | 2005 |
Cognitive and psychomotor performance, mood, and pressor effects of caffeine after 4, 6 and 8 h caffeine abstinence.
Topics: Administration, Oral; Adolescent; Adult; Affect; Blood Pressure; Caffeine; Central Nervous System St | 2005 |
Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction.
Topics: Adult; Affect; Attention; Blood Pressure; Caffeine; Central Nervous System Stimulants; Chromatograph | 2005 |
Caffeine deprivation state modulates coffee consumption but not attentional bias for caffeine-related stimuli.
Topics: Adolescent; Adult; Affect; Attention; Caffeine; Central Nervous System Stimulants; Coffee; Cognition | 2005 |
Psychostimulant and other effects of caffeine in 9- to 11-year-old children.
Topics: Affect; Arousal; Attention; Caffeine; Central Nervous System Stimulants; Child; Cognition; Dose-Resp | 2006 |
Acute effects of caffeine in volunteers with different patterns of regular consumption.
Topics: Adolescent; Adult; Affect; Aged; Analysis of Variance; Caffeine; Central Nervous System Stimulants; | 2006 |
Effects of dietary caffeine on topographic EEG after controlling for withdrawal and withdrawal reversal.
Topics: Adolescent; Adult; Affect; Analysis of Variance; Attention; Brain Mapping; Caffeine; Central Nervous | 2007 |
Effects of acute caffeine withdrawal on Short Category Test performance in sleep-deprived individuals.
Topics: Adult; Caffeine; Cognition Disorders; Concept Formation; Double-Blind Method; Drug Combinations; Eth | 2007 |
Coffee: should we stop drinking it?
Topics: Caffeine; Clinical Trials as Topic; Coffee; Humans; Substance Withdrawal Syndrome; Substance-Related | 1981 |
Anxiety and muscle tension as consequences of caffeine withdrawal.
Topics: Adult; Anxiety; Caffeine; Humans; Muscle Contraction; Substance Withdrawal Syndrome | 1980 |
Perioperative administration of caffeine tablets for prevention of postoperative headaches.
Topics: Adult; Aged; Caffeine; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged; Postoperati | 1995 |
Effects of caffeine deprivation on complex human functioning.
Topics: Adult; Blood Pressure; Caffeine; Cross-Over Studies; Double-Blind Method; Female; Heart Rate; Humans | 1995 |
Caffeine withdrawal symptoms and self-administration following caffeine deprivation.
Topics: Adult; Caffeine; Coffee; Female; Humans; Male; Psychomotor Performance; Reinforcement Schedule; Self | 1995 |
Cardiovascular, behavioral, and subjective effects of caffeine under field conditions.
Topics: Adult; Arousal; Behavior; Blood Pressure; Caffeine; Female; Headache; Heart Rate; Hemodynamics; Huma | 1994 |
Effects of acute caffeine withdrawal on habituated male runners.
Topics: Adult; Anaerobic Threshold; Caffeine; Carbohydrate Metabolism; Double-Blind Method; Exercise; Fats; | 1994 |
Caffeine antagonizes EEG effects of tobacco withdrawal.
Topics: Adult; Affect; Blood Pressure; Caffeine; Coffee; Drug Interactions; Electroencephalography; Heart Ra | 1994 |
The acute and chronic effects of ephedrine/caffeine mixtures on energy expenditure and glucose metabolism in humans.
Topics: Adult; Blood Glucose; Caffeine; Double-Blind Method; Drug Therapy, Combination; Energy Metabolism; E | 1993 |
Caffeine metabolism and epinephrine responses during exercise in users and nonusers.
Topics: Adult; Blood Glucose; Caffeine; Catecholamines; Epinephrine; Exercise; Fatty Acids, Nonesterified; G | 1993 |
Blood pressure, plasma catecholamine and renin responses to caffeine in elderly hypertensives.
Topics: Aged; Aged, 80 and over; Blood Pressure; Caffeine; Catecholamines; Double-Blind Method; Female; Huma | 1993 |
Caffeine self-administration and withdrawal: incidence, individual differences and interrelationships.
Topics: Adult; Arousal; Caffeine; Coffee; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hum | 1993 |
Mood and performance effects of caffeine in relation to acute and chronic caffeine deprivation.
Topics: Acute Disease; Adolescent; Adult; Affect; Anger; Caffeine; Central Nervous System Stimulants; Chroni | 1995 |
The effect of caffeine on cue exposure responses in ex-smokers.
Topics: Adult; Arousal; Caffeine; Cues; Female; Humans; Male; Single-Blind Method; Smoking Cessation; Substa | 1996 |
Caffeine reinforcement: the role of withdrawal.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Female; Headache; Humans; M | 1997 |
Prophylactic intravenous administration of caffeine and recovery after ambulatory surgical procedures.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Caffeine; Central Nervous System Stimulants; Coffee; Dou | 1997 |
Effects of brief caffeinated-beverage deprivation on mood, symptoms, and psychomotor performance.
Topics: Adult; Affect; Beverages; Caffeine; Central Nervous System Stimulants; Cognition; Fatigue; Female; H | 1997 |
Somatic dysfunction increase during caffeine withdrawal.
Topics: Adult; Analysis of Variance; Caffeine; Central Nervous System Stimulants; Electroencephalography; Fe | 1997 |
Absorption and subjective effects of caffeine from coffee, cola and capsules.
Topics: Adult; Affect; Area Under Curve; Behavior; Caffeine; Capsules; Carbonated Beverages; Central Nervous | 1997 |
Caffeine dependence in schoolchildren?
Topics: Affect; Caffeine; Central Nervous System Stimulants; Child; Female; Humans; Male; Substance Withdraw | 1997 |
Effects of caffeine withdrawal on humans living in a residential laboratory.
Topics: Adult; Affect; Caffeine; Central Nervous System Stimulants; Eating; Female; Humans; Male; Psychomoto | 1997 |
Caffeine withdrawal symptoms following brief caffeine deprivation.
Topics: Adolescent; Adult; Affect; Blood Pressure; Caffeine; Central Nervous System Stimulants; Double-Blind | 1997 |
Acute and chronic effects of caffeine on performance, mood, headache, and sleep.
Topics: Acute Disease; Affect; Analysis of Variance; Caffeine; Chi-Square Distribution; Chronic Disease; Cro | 1998 |
Physical dependence increases the relative reinforcing effects of caffeine versus placebo.
Topics: Adult; Analysis of Variance; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double | 1998 |
Caffeine deprivation affects vigilance performance and mood.
Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; | 1998 |
Mood and psychomotor performance effects of the first, but not of subsequent, cup-of-coffee equivalent doses of caffeine consumed after overnight caffeine abstinence.
Topics: Adolescent; Adult; Affect; Attention; Body Weight; Caffeine; Central Nervous System Stimulants; Coff | 1998 |
Caffeine withdrawal: a parametric analysis of caffeine dosing conditions.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Cluster Analysis; Diet; Double-Blind Method; Fem | 1999 |
The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment.
Topics: Adult; Affect; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Female; Health Surv | 1999 |
A controlled study of flumazenil-precipitated withdrawal in chronic low-dose benzodiazepine users.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Central Nervous System Stimulants; Double-Bli | 1999 |
Caffeine withdrawal increases cerebral blood flow velocity and alters quantitative electroencephalography (EEG) activity.
Topics: Adult; Affect; Anterior Cerebral Artery; Caffeine; Central Nervous System Stimulants; Cerebrovascula | 2000 |
Effects of caffeine on sensorimotor gating of the startle reflex in normal control subjects: impact of caffeine intake and withdrawal.
Topics: Adolescent; Adult; Blood Pressure; Caffeine; Double-Blind Method; Heart Rate; Humans; Male; Reflex; | 2000 |
Safety and efficacy of treatment with an ephedrine/caffeine mixture. The first double-blind placebo-controlled pilot study in adolescents.
Topics: Adipose Tissue; Adolescent; Apolipoproteins B; Blood Pressure; Body Composition; Caffeine; Double-Bl | 2000 |
Caffeine use as a model of acute and chronic insomnia.
Topics: Acute Disease; Adolescent; Adult; Arousal; Attention; Caffeine; Chronic Disease; Circadian Rhythm; D | 1992 |
Withdrawal syndrome after the double-blind cessation of caffeine consumption.
Topics: Adult; Caffeine; Depression; Diet; Double-Blind Method; Female; Headache; Humans; Interview, Psychol | 1992 |
Abrupt outpatient withdrawal of medication in analgesic-abusing migraineurs.
Topics: Adult; Amitriptyline; Analgesics; Caffeine; Ergotamine; Evaluation Studies as Topic; Female; Follow- | 1991 |
Caffeine self-administration, withdrawal, and adverse effects among coffee drinkers.
Topics: Adult; Caffeine; Coffee; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged; Self Medi | 1991 |
Low-dose caffeine physical dependence in humans.
Topics: Adult; Affect; Behavior; Caffeine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Admin | 1990 |
Physical dependence on and toxicity from caffeine.
Topics: Arousal; Caffeine; Coffee; Double-Blind Method; Humans; Randomized Controlled Trials as Topic; Subst | 1989 |
The effects of caffeine on caffeine users and non-users.
Topics: Adult; Affect; Blood Pressure; Caffeine; Humans; Kinetics; Male; Middle Aged; Movement; Psychomotor | 1986 |
Human coffee drinking: reinforcing and physical dependence producing effects of caffeine.
Topics: Adult; Caffeine; Coffee; Drinking; Emotions; Headache; Humans; Male; Middle Aged; Psychomotor Perfor | 1986 |
Propoxyphene hydrochloride. A critical review.
Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headac | 1970 |
165 other studies available for caffeine and Substance Withdrawal Syndrome
Article | Year |
---|---|
Prevalence, characteristics, and factors associated with caffeine-withdrawal headache during the first day of Ramadan.
Topics: Body Weight; Caffeine; Cross-Sectional Studies; Headache; Humans; Prevalence; Substance Withdrawal S | 2023 |
Sex differences in endocannabinoid tone in a pilot study of cannabis use disorder and acute cannabis abstinence.
Topics: Adult; Caffeine; Cannabinoid Receptor Agonists; Cannabis; Endocannabinoids; Female; Humans; Male; Ma | 2023 |
Reversible cerebral vasoconstriction syndrome after sudden caffeine withdrawal.
Topics: Caffeine; Central Nervous System Stimulants; Cerebral Angiography; Cerebral Hemorrhage; Computed Tom | 2019 |
Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Exercise; Female; Humans; Male; Memory, Short-Te | 2019 |
Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Choice | 2020 |
Mechanisms for the reduction of caffeine consumption: What, how and why.
Topics: Adult; Caffeine; Coffee; Databases, Factual; Fatigue; Female; Humans; Male; Substance Withdrawal Syn | 2020 |
Low but not moderate amounts of caffeine increase co-consumption of ethanol in C57BL/6J mice.
Topics: Alcohol Drinking; Animals; Anxiety; Behavior, Animal; Binge Drinking; Caffeine; Disease Models, Anim | 2021 |
The impacts of caffeine administration, expectancies, and related stimuli on coffee craving, withdrawal, and self-administration.
Topics: Caffeine; Coffee; Craving; Cues; Female; Humans; Male; Self Administration; Substance Withdrawal Syn | 2022 |
Reversible cerebral vasoconstriction syndrome secondary to caffeine withdrawal.
Topics: Adult; Brain; Caffeine; Cerebral Arteries; Coffee; Energy Drinks; Headache Disorders, Primary; Human | 2018 |
Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Coffee; Female; Humans; Male; Middle Aged; Self | 2017 |
Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model.
Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Ethanol; Male; Pentylenetetrazole; Rats; Rats, Sprague | 2018 |
Caffeine use disorder: An item-response theory analysis of proposed DSM-5 criteria.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Cigarette Smoking; Craving; Cross-Sectional Stud | 2018 |
The effect of dose expectancies on caffeine withdrawal symptoms during tapered dose reduction.
Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Female; Humans; Male; Psychotropic D | 2019 |
Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Caffeine; Cotinine; Exploratory Behavior; Female; Male; M | 2019 |
Investigating the role of expectancy in caffeine withdrawal using the balanced placebo design.
Topics: Adolescent; Adult; Anticipation, Psychological; Caffeine; Central Nervous System Stimulants; Coffee; | 2019 |
Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice.
Topics: Aging; Animals; Anxiety; Caffeine; Central Nervous System Stimulants; Conditioning, Psychological; D | 2016 |
Caffeine-induced mania in a patient with caffeine use disorder: A case report.
Topics: Aged; Bipolar Disorder; Caffeine; Comorbidity; Dose-Response Relationship, Drug; Energy Drinks; Huma | 2015 |
Placebo caffeine reduces withdrawal in abstinent coffee drinkers.
Topics: Adult; Attention; Caffeine; Coffee; Craving; Eating; Fatigue; Female; Food; Humans; Male; Psychomoto | 2016 |
Caffeine discontinuation improves acute migraine treatment: a prospective clinic-based study.
Topics: Adult; Caffeine; Coffee; Female; Follow-Up Studies; Humans; Male; Middle Aged; Migraine Disorders; O | 2016 |
Activation of Peripheral κ-Opioid Receptors Normalizes Caffeine Effects Modified in Nicotine-Dependent Rats during Nicotine Withdrawal.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Gastric | 2016 |
Effects of acute caffeine on anxiety-related behavior in rats chronically exposed to the drug, with some evidence of possible withdrawal-reversal.
Topics: Animals; Anxiety; Caffeine; Central Nervous System Stimulants; Exploratory Behavior; Female; Male; M | 2017 |
Withdrawal-like behavior in planarians is dependent on drug exposure duration.
Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inh | 2008 |
Conditioned flavor avoidance as a measure of withdrawal in rats chronically exposed to a caffeine solution.
Topics: Administration, Oral; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Central Nervous Syste | 2008 |
Fourteen well-described caffeine withdrawal symptoms factor into three clusters.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Female; Humans; Likelihood Functions; Male; Odds | 2009 |
Psychosocial withdrawal characteristics of nicotine compared with alcohol and caffeine.
Topics: Adult; Aged; Behavior, Addictive; Blood Pressure; Caffeine; Central Nervous System Depressants; Cent | 2008 |
Caffeine-withdrawal headache induced by hemodialysis.
Topics: Caffeine; Central Nervous System Stimulants; Cerebrovascular Circulation; Coffee; Disease Progressio | 2009 |
Functional interaction between purinergic system and opioid withdrawal: in vitro evidence.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor | 2009 |
Caffeine in pregnancy: a cause for concern?
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Caffeine; Central Nervous System Stimulants; F | 2009 |
Patterns of caffeine consumption in psychiatric patients. An Italian study.
Topics: Adult; Age Factors; Caffeine; Central Nervous System Stimulants; Comorbidity; Feeding and Eating Dis | 2010 |
Caffeine modulates attention network function.
Topics: Affect; Attention; Caffeine; Central Nervous System Stimulants; Cues; Dose-Response Relationship, Dr | 2010 |
Caffeine expectancy: instrument development in the Rasch measurement framework.
Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Culture; Female; Hu | 2009 |
A comparison of the effects of caffeine following abstinence and normal caffeine use.
Topics: Adult; Affect; Attention; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, D | 2009 |
Modeling withdrawal syndrome in zebrafish.
Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Diazepam; Disease Models, Animal; Ethanol; Exploratory | 2010 |
The potential dangers of caffeine in pregnancy.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Caffeine; Central Nervous System Stimulants; C | 2010 |
First evidence that drugs of abuse produce behavioral sensitization and cross sensitization in planarians.
Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Cocaine; Dose-Response Relat | 2010 |
Acute and adaptive motor responses to caffeine in adolescent and adult rats.
Topics: Adaptation, Physiological; Age Factors; Animals; Caffeine; Dose-Response Relationship, Drug; Male; M | 2011 |
Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats.
Topics: Animals; Brain; Caffeine; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Immo | 2012 |
Development of the caffeine withdrawal symptom questionnaire: caffeine withdrawal symptoms cluster into 7 factors.
Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Cluster Analysis; Coffee; Fatigue; Female; Headache; H | 2012 |
Characterization of individuals seeking treatment for caffeine dependence.
Topics: Adult; Anxiety; Caffeine; Coffee; Female; Humans; Male; Middle Aged; Sleep Wake Disorders; Substance | 2012 |
Common psychiatric disorders and caffeine use, tolerance, and withdrawal: an examination of shared genetic and environmental effects.
Topics: Adult; Anorexia Nervosa; Anxiety Disorders; Bulimia; Caffeine; Depressive Disorder, Major; Diseases | 2012 |
The effects of caffeine abstinence on sleep: a pilot study.
Topics: Adult; Caffeine; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Pilot Projects; Slee | 2013 |
Caffeine withdrawal: a model for migraine?
Topics: Caffeine; Headache; Humans; Models, Biological; Substance Withdrawal Syndrome | 2002 |
Caffeine use and dependence in adolescents: one-year follow-up.
Topics: Adolescent; Analysis of Variance; Caffeine; Chi-Square Distribution; Female; Follow-Up Studies; Huma | 2002 |
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Dopamine Antagonists; Drug | 2002 |
Absence of reinforcing, mood and psychomotor performance effects of caffeine in habitual non-consumers of caffeine.
Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Coffee; Female; Hum | 2003 |
Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Chr | 2003 |
Caffeine and coffee tolerance.
Topics: Adenosine; Baroreflex; Blood Pressure; Caffeine; Coffee; Drug Tolerance; Heart Rate; Humans; Hyperte | 2003 |
WAKEFULNESS CAUSED BY CAFFEINE.
Topics: Biomedical Research; Caffeine; Headache; Humans; Lactose; Pharmacology; Sleep; Sleep Wake Disorders; | 1964 |
Caffeine-withdrawal headache. The Vågå study of headache epidemiology.
Topics: Adolescent; Adult; Aged; Caffeine; Central Nervous System Stimulants; Coffee; Denmark; Female; Heada | 2004 |
Caffeine withdrawal syndrome in social interaction test in mice: effects of the NMDA receptor channel blockers, memantine and neramexane.
Topics: Animals; Caffeine; Cyclopentanes; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Mal | 2004 |
Barbiturate withdrawal following Internet purchase of Fioricet.
Topics: Acetaminophen; Adult; Barbiturates; Caffeine; Drug Combinations; Female; Humans; Internet; Substance | 2004 |
[Alimentary trigger factors that provoke migraine and tension-type headache].
Topics: Cacao; Caffeine; Dehydration; Digestive System Diseases; Humans; Migraine Disorders; Substance Withd | 2006 |
Dietary caffeine, performance and mood: enhancing and restorative effects after controlling for withdrawal reversal.
Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Diet; Female; Human | 2005 |
Attentional bias for caffeine-related stimuli in high but not moderate or non-caffeine consumers.
Topics: Adolescent; Adult; Affect; Attention; Caffeine; Cues; Dose-Response Relationship, Drug; Female; Huma | 2005 |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats.
Topics: Adenosine; Animals; Caffeine; Coffea; Disease Models, Animal; Dose-Response Relationship, Drug; Drin | 2005 |
What are caffeine's psychological benefits and risks?
Topics: Caffeine; Central Nervous System Stimulants; Humans; Sleep; Sleep Deprivation; Substance Withdrawal | 2005 |
Caffeine dependence in combination with a family history of alcoholism as a predictor of continued use of caffeine during pregnancy.
Topics: Adult; Alcoholism; Behavior, Addictive; Caffeine; Coffee; Comorbidity; Family Health; Female; Humans | 2005 |
Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Corpus Stri | 2006 |
Effects of repeated doses of caffeine on performance and alertness: new data and secondary analyses.
Topics: Adult; Affect; Analysis of Variance; Arousal; Attention; Caffeine; Central Nervous System Stimulants | 2007 |
Seizures in a night club.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Beverages; Caffeine; Drug Interactions | 2007 |
Improvement from treatment-resistant schizoaffective disorder, manic type after stopping heavy caffeine intake: a case report.
Topics: Bipolar Disorder; Caffeine; Central Nervous System Stimulants; Humans; Male; Middle Aged; Psychotic | 2008 |
CNS stimulants and the look-alike drugs.
Topics: Amphetamine; Caffeine; Central Nervous System Stimulants; Depressive Disorder; Ephedrine; Humans; Il | 1984 |
Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Huma | 1981 |
Effects of caffeine withdrawal on isoproterenol-stimulated cyclic adenosine monophosphate.
Topics: Adrenal Medulla; Adult; Alprostadil; Caffeine; Cyclic AMP; Drug Tolerance; Humans; In Vitro Techniqu | 1981 |
Caffeine: psychiatric grounds for concern.
Topics: Caffeine; Cerebral Cortex; Humans; Psychotropic Drugs; Stimulation, Chemical; Substance Withdrawal S | 1983 |
Lethargy, anxiety, and impotence in a diabetic.
Topics: Adult; Anxiety; Caffeine; Diabetes Complications; Diabetes Mellitus; Erectile Dysfunction; Humans; H | 1982 |
Relevance of caffeine symptomatology to alcohol rehabilitation efforts.
Topics: Adult; Alcoholism; Beverages; Caffeine; Evaluation Studies as Topic; Female; Humans; Male; Middle Ag | 1980 |
Apnea associated with theophylline withdrawal in a term neonate.
Topics: Apnea; Caffeine; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange | 1982 |
Caffeine and human behavior: arousal, anxiety, and performance effects.
Topics: Achievement; Anxiety; Arousal; Caffeine; Cerebral Cortex; Humans; Substance Withdrawal Syndrome | 1982 |
Caffeinism: subjective quantitative aspect of withdrawal syndrome.
Topics: Adult; Caffeine; Humans; Male; Substance Withdrawal Syndrome | 1981 |
Headache.
Topics: Caffeine; Headache; Humans; Substance Withdrawal Syndrome | 1980 |
Caffeine-withdrawal headache: a clinical profile.
Topics: Adult; Anxiety; Caffeine; Depression; Female; Headache; Humans; Substance Withdrawal Syndrome | 1980 |
Caffeine withdrawal elevates urinary MHPG excretion.
Topics: Caffeine; Humans; Methoxyhydroxyphenylglycol; Substance Withdrawal Syndrome | 1981 |
24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression.
Topics: Analysis of Variance; Animals; Brain; Caffeine; Depression; Dose-Response Relationship, Drug; Drug A | 1995 |
Topographic quantitative EEG measures of alpha and theta power changes during caffeine withdrawal: preliminary findings from normal subjects.
Topics: Adolescent; Adult; Alpha Rhythm; Brain Mapping; Caffeine; Cerebral Cortex; Electroencephalography; F | 1995 |
Caffeine and psychomotor performance: a reply to James.
Topics: Affect; Animals; Arousal; Caffeine; Humans; Psychomotor Performance; Substance Withdrawal Syndrome | 1995 |
Caffeine, caffeine withdrawal and psychomotor performance: a reply to James.
Topics: Animals; Caffeine; Humans; Psychomotor Performance; Substance Withdrawal Syndrome | 1995 |
Locomotor activity in mice during chronic treatment with caffeine and withdrawal.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Caffeine; Dopamine Agents; Dose-Response Relationsh | 1993 |
Ethanol inhibits NMDA-receptor mediated regulation of immediate early gene expression.
Topics: Alcoholism; Animals; Brain; Caffeine; Dizocilpine Maleate; Ethanol; Gene Expression Regulation; Gene | 1993 |
Caffeine withdrawal increases lithium blood levels.
Topics: Adult; Aged; Bipolar Disorder; Caffeine; Dose-Response Relationship, Drug; Female; Humans; Lithium; | 1995 |
Does caffeine enhance or merely restore degraded psychomotor performance?
Topics: Arousal; Attention; Caffeine; Circadian Rhythm; Coffee; Dose-Response Relationship, Drug; Humans; Ps | 1994 |
Drinking history is related to persistent blood pressure dysregulation in postwithdrawal alcoholics.
Topics: Adult; Alcoholism; Arousal; Caffeine; Ethanol; Follow-Up Studies; Humans; Hypertension; Male; Middle | 1994 |
Barbiturate, analgesic, and caffeine withdrawal.
Topics: Adult; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Barbiturates; Caffeine; Coma; Drug Comb | 1994 |
Caffeine dependence syndrome. Evidence from case histories and experimental evaluations.
Topics: Adult; Caffeine; Case-Control Studies; Double-Blind Method; Female; Humans; Male; Psychiatric Status | 1994 |
Caffeine dependence. What are the implications?
Topics: Caffeine; Humans; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Substance-Related | 1994 |
Postoperative transient hemihypaesthesia and severe headache associated with caffeine withdrawal.
Topics: Adult; Caffeine; Coffee; Female; Headache; Humans; Hypesthesia; Postoperative Complications; Substan | 1994 |
Caffeine withdrawal: apparent heterologous sensitization to adenosine and prostacyclin actions in human platelets.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adolescent; Adult; Alprostadil; Blood Platelets; Caffe | 1993 |
Caffeine withdrawal, metoclopramide, and depression.
Topics: Adult; Caffeine; Depressive Disorder; Drug Interactions; Humans; Male; Metoclopramide; Substance Wit | 1993 |
Primary caffeine dependence: a case report.
Topics: Adult; Caffeine; Humans; Male; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding.
Topics: Animals; Brain; Caffeine; Dose-Response Relationship, Drug; Infusion Pumps, Implantable; Infusions, | 1993 |
Perioperative ingestion of caffeine and postoperative headache.
Topics: Adult; Aged; Caffeine; Coffee; Female; Headache; Humans; Male; Middle Aged; Postoperative Period; Pr | 1993 |
For want of a cup of coffee.
Topics: Caffeine; Headache; Humans; Postoperative Period; Preoperative Care; Substance Withdrawal Syndrome | 1993 |
[The smart person will never sleep late; 'weekend headache' due to late and insufficient intake of caffeine].
Topics: Adult; Caffeine; Female; Humans; Male; Middle Aged; Migraine Disorders; Substance Withdrawal Syndrom | 1993 |
Overnight caffeine abstinence and negative reinforcement of preference for caffeine-containing drinks.
Topics: Adolescent; Adult; Affect; Caffeine; Conditioning, Psychological; Female; Humans; Male; Reinforcemen | 1995 |
[Caffeine--the gentle addictive stimulant].
Topics: Caffeine; Coffee; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Mitral regurgitation caused by chronic ergotamine use.
Topics: Adult; Caffeine; Chronic Disease; Drug Combinations; Ergotamine; Ergotism; Female; Humans; Migraine | 1996 |
Caffeine dependence: an alternative view.
Topics: Affect; Caffeine; Headache; Humans; Models, Psychological; Substance Withdrawal Syndrome; Substance- | 1996 |
Does caffeine cessation increase firing rates of diffuse paroxysmal slowing dysrhythmia? A serendipitous observation.
Topics: Adult; Caffeine; Cerebral Cortex; Electroencephalography; Evoked Potentials; Female; Humans; Male; S | 1996 |
[Episodic headache, diminished performance and depressive mood].
Topics: Adult; Caffeine; Depression; Fatigue; Headache; Humans; Male; Substance Withdrawal Syndrome | 1996 |
Influence of caffeine and caffeine withdrawal on headache and cerebral blood flow velocities.
Topics: Adult; Caffeine; Cerebrovascular Circulation; Female; Headache; Humans; Male; Middle Aged; Substance | 1997 |
Anxiogenic action of caffeine: an experimental study in rats.
Topics: Animals; Anxiety; Caffeine; Central Nervous System Stimulants; Drug Tolerance; Exploratory Behavior; | 1997 |
A systematic survey of caffeine intake in Vermont.
Topics: Adolescent; Adult; Age Factors; Age of Onset; Aged; Alcohol Drinking; Beverages; Caffeine; Central N | 1997 |
Caffeine withdrawal after head and neck surgery.
Topics: Caffeine; Carcinoma, Squamous Cell; Humans; Male; Middle Aged; Pharyngeal Neoplasms; Postoperative C | 1997 |
Nicotine and caffeine use as confounds in psychiatric studies.
Topics: Caffeine; Case-Control Studies; Central Nervous System Stimulants; Humans; Nicotine; Nicotinic Agoni | 1997 |
Caffeine abstinence augments the systolic blood pressure response to adenosine in humans.
Topics: Adenosine; Adult; Blood Pressure; Caffeine; Heart Rate; Humans; Male; Middle Aged; Purinergic P1 Rec | 1998 |
Effects of caffeine withdrawal from the diet on the metabolism of clozapine in schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Biological Availability; Biotransformation; Caffeine; Chromatography, H | 1998 |
Caffeine withdrawal in normal school-age children.
Topics: Analysis of Variance; Attention; Caffeine; Central Nervous System Stimulants; Child; Cognition Disor | 1998 |
Regulation of G proteins and adenylyl cyclase in brain regions of caffeine-tolerant and -dependent mice.
Topics: Adenylyl Cyclases; Animals; Behavior, Animal; Brain; Caffeine; Dose-Response Relationship, Drug; Dru | 1998 |
Endorsement of DSM-IV dependence criteria among caffeine users.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Female; Humans; Male; Middle Aged; Psychiatric S | 1998 |
Adenosine kinase inhibitors attenuate opiate withdrawal via adenosine receptor activation.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine Kinase; Animals; Body Weight; Caffeine; De | 1998 |
The effects of caffeine withdrawal on cognitive P300 auditory and visual evoked potentials.
Topics: Adolescent; Adult; Caffeine; Event-Related Potentials, P300; Evoked Potentials, Auditory; Evoked Pot | 1999 |
Caffeine intake, tolerance, and withdrawal in women: a population-based twin study.
Topics: Adult; Caffeine; Carbonated Beverages; Coffee; Diseases in Twins; Drug Overdose; Drug Tolerance; Fem | 1999 |
Intravascular source of adenosine during forearm ischemia in humans: implications for reactive hyperemia.
Topics: Adenosine; Adult; Caffeine; Female; Forearm; Humans; Hyperemia; Ischemia; Male; Microdialysis; Muscl | 1999 |
Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats.
Topics: Adenosine; Animals; Brain; Caffeine; Cocaine; Differential Threshold; Dopamine Uptake Inhibitors; Dr | 1999 |
Adenosine receptors are involved in the control of acute naloxone-precipitated withdrawal: in vitro evidence.
Topics: Adenosine; Animals; Caffeine; Dipyridamole; Guinea Pigs; Ileum; In Vitro Techniques; Male; Naloxone; | 2000 |
Reversal of caffeine withdrawal by ingestion of a soft beverage.
Topics: Adult; Beverages; Blood Glucose; Blood Pressure; Caffeine; Cerebrovascular Circulation; Female; Huma | 2000 |
Caffeine increases paragigantocellularis neuronal firing rate and induces withdrawal signs in morphine-dependent rats.
Topics: Adenosine; Analgesics, Opioid; Animals; Caffeine; Electrophysiology; Male; Medulla Oblongata; Microi | 2001 |
Clinical features of withdrawal headache following overuse of triptans and other headache drugs.
Topics: Analgesics; Caffeine; Causality; Codeine; Drug Overdose; Headache; Headache Disorders; Humans; Prosp | 2002 |
Consequences of interaction between opioid and receptor.
Topics: Analgesics, Opioid; Animals; Brain; Caffeine; Cyclic AMP; Cyclic GMP; Drug Tolerance; Humans; Ileum; | 1977 |
Dyskinesia after discountinuation of compound analgesic containing oxycodone.
Topics: Aspirin; Caffeine; Codeine; Drug Combinations; Female; Humans; Middle Aged; Movement Disorders; Oxyc | 1977 |
Two types of insomnia: too much waking or not enough sleep.
Topics: Age Factors; Caffeine; Electroencephalography; Eye Movements; Female; Humans; Hypnotics and Sedative | 1975 |
Morphone abstinence and quasi-abstinence effects after phosphodiesterase inhibitors and naloxone.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffei | 1975 |
Caffeine elicited withdrawal signs in morphine-dependent rhesus monkeys.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Behavior, Animal; Benzoates; Brain; Caffeine; Conditio | 1978 |
Mechanism of quasi-morphine withdrawal behaviour induced by methylxanthines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Humans; | 1979 |
Caffeine-withdrawal headache and fasting.
Topics: Adolescent; Adult; Caffeine; Child; Coffee; Diet; Fasting; Female; Headache; Humans; Jews; Male; Sub | 1977 |
Evidence for withdrawal from caffeine by rats.
Topics: Animals; Avoidance Learning; Caffeine; Humans; Male; Rats; Saccharin; Substance Withdrawal Syndrome | 1977 |
Problems with non-prescribed agents.
Topics: Adult; Aged; Caffeine; Humans; Male; Middle Aged; Substance Withdrawal Syndrome | 1992 |
Caffeine tolerance and choice in humans.
Topics: Adult; Affect; Anxiety; Caffeine; Diet; Drug Tolerance; Female; Humans; Male; Psychiatric Status Rat | 1992 |
Clinical importance of caffeine withdrawal.
Topics: Caffeine; Humans; Substance Withdrawal Syndrome | 1992 |
Weekend attacks in migraine patients: caused by caffeine withdrawal?
Topics: Adolescent; Adult; Caffeine; Chi-Square Distribution; Female; Humans; Male; Middle Aged; Migraine Di | 1992 |
From the Alcohol, Drug Abuse, and Mental Health Administration.
Topics: Brain; Caffeine; Cocaine; Diazepam; Drug Synergism; Ethanol; Fetus; Humans; Memory; Memory Disorders | 1991 |
An original method for assessment of the jumping test.
Topics: Animals; Behavior, Animal; Caffeine; Guanfacine; Male; Methods; Mice; Mice, Inbred Strains; Morphine | 1991 |
Caffeine and theophylline as adenosine receptor antagonists in humans.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adult; Caffeine; Heart Rate; Humans; Male; Platelet Ag | 1991 |
Effects of caffeine on tobacco withdrawal.
Topics: Adult; Caffeine; Dose-Response Relationship, Drug; Female; Headache; Humans; Hunger; Male; Patient C | 1991 |
Does restriction of caffeine intake affect mixed function oxidase activity and caffeine metabolism?
Topics: 17-Hydroxycorticosteroids; Adult; Caffeine; Coffee; Enzyme Induction; Female; gamma-Glutamyltransfer | 1990 |
Is caffeine withdrawal the mechanism of postoperative headache?
Topics: Adult; Aged; Anesthesia, General; Caffeine; Female; Headache; Humans; Male; Middle Aged; Postoperati | 1991 |
Do-Do abuse.
Topics: Adult; Antitussive Agents; Caffeine; Drug Combinations; Ephedrine; Female; Humans; Male; Middle Aged | 1990 |
Headache caused by caffeine withdrawal among moderate coffee drinkers switched from ordinary to decaffeinated coffee: a 12 week double blind trial.
Topics: Adult; Caffeine; Coffee; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged; Substance | 1990 |
The anxiogenic effects of caffeine.
Topics: Adult; Anxiety Disorders; Caffeine; Diet; Female; Humans; Panic; Substance Withdrawal Syndrome | 1990 |
The effect of smoking on caffeine elimination: implications for its use as a semiquantitative test of liver function.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Antipyrine; Caffeine; Chromatography, High Pressure Liquid; Fema | 1988 |
Caffeine: use and abuse.
Topics: Caffeine; Female; Health Education; Humans; Male; Nursing Staff; Students, Nursing; Substance Withdr | 1989 |
Does caffeine withdrawal contribute to postanaesthetic morbidity?
Topics: Adolescent; Adult; Aged; Anesthesia, General; Caffeine; Female; Headache; Humans; Male; Middle Aged; | 1989 |
Cardiovascular reactivity, mood, and task performance in deprived and nondeprived coffee drinkers.
Topics: Adolescent; Adult; Affect; Arousal; Attention; Caffeine; Coffee; Color Perception; Discrimination Le | 1989 |
Caffeine abstinence effects in humans.
Topics: Arousal; Caffeine; Fatigue; Headache; Humans; Substance Withdrawal Syndrome | 1989 |
Longterm prognosis of analgesic withdrawal in patients with drug-induced headaches.
Topics: Adult; Caffeine; Ergotamine; Female; Headache; Humans; Male; Middle Aged; Prognosis; Pyrazoles; Pyra | 1989 |
Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex.
Topics: Adenosine; Adenylyl Cyclases; Animals; Caffeine; Cerebral Cortex; Cross-Linking Reagents; Guanine Nu | 1986 |
The caffeine withdrawal flush: report of a case of "weekend flushing".
Topics: Adult; Caffeine; Female; Flushing; Humans; Substance Withdrawal Syndrome; Time Factors | 1986 |
Pharmacologic specificity of tolerance to caffeine-induced stimulation of locomotor activity.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Male; Motor | 1987 |
A survey of caffeine use and associated side effects in a college population.
Topics: Adult; Caffeine; Data Collection; Fatigue; Female; Humans; Male; Middle Aged; Students; Substance Wi | 1988 |
Behavioral dependence on caffeine and phencyclidine in rhesus monkeys: interactive effects.
Topics: Animals; Behavior, Animal; Caffeine; Drug Interactions; Feeding Behavior; Macaca mulatta; Male; Phen | 1988 |
Lithium tremor and caffeine intake: two cases of drinking less and shaking more.
Topics: Adult; Bipolar Disorder; Caffeine; Coffee; Female; Humans; Lithium; Middle Aged; Substance Withdrawa | 1988 |
Effects of caffeine withdrawal on motor performance and heart rate changes.
Topics: Adult; Attention; Caffeine; Female; Heart Rate; Humans; Male; Psychomotor Performance; Reaction Time | 1988 |
Endogenous adenosine and hemorrhagic shock: effects of caffeine administration or caffeine withdrawal.
Topics: Adenosine; Animals; Blood Pressure; Caffeine; Male; Rats; Rats, Inbred Strains; Shock, Hemorrhagic; | 1988 |
[Clouding of consciousness on the withdrawal of caffeine and sodium benzoate].
Topics: Benzoates; Benzoic Acid; Caffeine; Cognition Disorders; Consciousness Disorders; Humans; Male; Middl | 1988 |
Caffeine withdrawal headache.
Topics: Adult; Caffeine; Diet; Headache; Humans; Male; Pharmaceutical Preparations; Substance Withdrawal Syn | 1987 |
Caffeine and the benign encephalopathy of pregnancy.
Topics: Brain Diseases; Caffeine; Female; Humans; Pregnancy; Pregnancy Complications; Substance Withdrawal S | 1987 |
Caffeine withdrawal symptoms.
Topics: Caffeine; Humans; Substance Withdrawal Syndrome | 1987 |
Tolerance to caffeine-induced stimulation of locomotor activity in rats.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Motor Activity; Rats; Rat | 1986 |
Acute abstinence syndrome after epidural injection of butorphanol.
Topics: Adult; Anesthesia, Epidural; Aspirin; Blood Pressure; Butorphanol; Caffeine; Cesarean Section; Codei | 1985 |
Caffeine consumption, withdrawal and cerebral blood flow.
Topics: Adult; Caffeine; Cerebrovascular Circulation; Female; Humans; Male; Middle Aged; Substance Withdrawa | 1985 |
[Drugs and traffic--drug effects on efficiency and its importance for traffic safety. II].
Topics: Accidents, Traffic; Adult; Analgesics; Anticoagulants; Anticonvulsants; Antihypertensive Agents; Caf | 1968 |
Anxiety or caffeinism: a diagnostic dilemma.
Topics: Adult; Anxiety Disorders; Cacao; Caffeine; Carbonated Beverages; Coffee; Diagnosis, Differential; Do | 1974 |
Migraine headaches.
Topics: Caffeine; Contraceptives, Oral; Cyproheptadine; Diagnosis, Differential; Diuretics; Drug Combination | 1972 |
Experimental studies on the effective procedure to inhibit the development of tolerance to and dependence on morphine.
Topics: Analgesia; Animals; Caffeine; Drug Synergism; Drug Tolerance; Haplorhini; Humans; Injections, Subcut | 1970 |
Lack of sobering effect of fructose-vitamin tablets.
Topics: Alcohol Drinking; Caffeine; Chlorophyll; Ethanol; Fructose; Humans; Pyridoxine; Substance Withdrawal | 1970 |