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caffeine and Substance Withdrawal Syndrome

caffeine has been researched along with Substance Withdrawal Syndrome in 261 studies

Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.

Research Excerpts

ExcerptRelevanceReference
"The effect of phased caffeine withdrawal and abstention on tinnitus severity was assessed using a pseudo-randomized, double-blinded, placebo-controlled crossover trial of 30 days duration."9.14Caffeine abstinence: an ineffective and potentially distressing tinnitus therapy. ( Claire, LS; McKenna, L; Rogers, PJ; Stothart, G, 2010)
"Interruption of daily caffeine consumption can cause caffeine withdrawal headache."9.08Perioperative administration of caffeine tablets for prevention of postoperative headaches. ( Drewe, J; Hampl, KF; Rüttimann, U; Schneider, MC; Ummenhofer, W, 1995)
"Maternal use of "social drugs" such as caffeine, ethanol and tobacco in pregnancy is on increase- -worldwide."8.85Peripartum implications of caffeine intake in pregnancy: is there cause for concern? ( Kuczkowski, KM, 2009)
"Daily caffeine intake/kg body weight and caffeine use disorder are significantly associated with a caffeine-withdrawal headache."8.31Prevalence, characteristics, and factors associated with caffeine-withdrawal headache during the first day of Ramadan. ( Al-Azayem, SA; El Desouky, ED; Fathy, W; Hammad, EM; Hussein, M; Magdy, R; Mahfouz, NA; Naguib, EM; Salem, MR, 2023)
"To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy."7.73Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005)
"The purpose of the study was to examine whether caffeine dependence and a family history of alcoholism are associated with continued use of caffeine during pregnancy."7.73Caffeine dependence in combination with a family history of alcoholism as a predictor of continued use of caffeine during pregnancy. ( Berger, N; Griffiths, RR; Haug, NA; Svikis, DS, 2005)
"In connection with the Vågå study of headache epidemiology, a search was made for caffeine-withdrawal headache in 1741 parishioners."7.72Caffeine-withdrawal headache. The Vågå study of headache epidemiology. ( Bakketeig, LS; Sjaastad, O, 2004)
"It is believed that adenosine is released in ischemic tissues and contributes to reactive hyperemia."7.70Intravascular source of adenosine during forearm ischemia in humans: implications for reactive hyperemia. ( Angel, M; Biaggioni, I; Cavalcante, J; Christman, B; Costa, F; Haile, V; Sulur, P, 1999)
"The extent to which daily caffeine use is associated with a substance dependence syndrome similar to that associated with other psychoactive drugs is unknown."7.69Caffeine dependence syndrome. Evidence from case histories and experimental evaluations. ( Griffiths, RR; Mumford, GK; Silverman, K; Strain, EC, 1994)
"Caffeine consumption may cause headache, particularly migraine."7.69Influence of caffeine and caffeine withdrawal on headache and cerebral blood flow velocities. ( Couturier, EG; Laman, DM; van Duijn, H; van Duijn, MA, 1997)
"The interruption of daily consumption of caffeine-containing beverages can cause headache and other symptoms within 8 hours."7.68Perioperative ingestion of caffeine and postoperative headache. ( Danielson, DR; Ereth, MH; Weber, JG, 1993)
"This study examined the hypothesis that headache after general anesthesia is related to a caffeine withdrawal state."7.68Is caffeine withdrawal the mechanism of postoperative headache? ( Fennelly, M; Galletly, DC; Purdie, GI, 1991)
"Lithium tremor worsened in two patients when caffeine (coffee) was eliminated from their diets."7.67Lithium tremor and caffeine intake: two cases of drinking less and shaking more. ( Jefferson, JW, 1988)
"Plasma adenosine concentrations doubled when rats were subjected to 90 min of profound hemorrhagic shock."7.67Endogenous adenosine and hemorrhagic shock: effects of caffeine administration or caffeine withdrawal. ( Conlay, LA; Evoniuk, G; Wurtman, RJ, 1988)
"A review of the recent literature shows the role of caffeine in the physiology, mood, and behavior of persons to be a complex one including changes in arousal, anxiety, and performance."7.66Caffeine and human behavior: arousal, anxiety, and performance effects. ( Julia, HL; Sawyer, DA; Turin, AC, 1982)
"The effects of caffeine on specific mental illnesses and the medications used to treat them will be discussed."6.39Caffeine and its effect on persons with mental disorders. ( Simmons, DH, 1996)
"Caffeine was administrated during all prenatal and postnatal life (CAF, 0."5.51Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence. ( Abreu-Villaça, Y; da Silva Gonçalves, B; Filgueiras, CC; Leal-Rocha, PH; Manhães, AC; Ribeiro-Carvalho, A, 2019)
"We assessed the seizure vulnerability and anxiety responses following the chronic co-administration of, and withdrawal from, caffeine and ethanol in male rats."5.48Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model. ( Alele, PE; Matovu, D, 2018)
"Caffeine was injected at doses of 80 mg/kg daily for five days."5.2924h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. ( Haleem, DJ; Haleem, MA; Yasmeen, A; Zafar, A, 1995)
"While caffeine benefits motor performance and tolerance develops to its tendency to increase anxiety/jitteriness, tolerance to its effects on sleepiness means that frequent consumption fails to enhance mental alertness and mental performance."5.17Faster but not smarter: effects of caffeine and caffeine withdrawal on alertness and performance. ( Heatherley, SV; Mullings, EL; Rogers, PJ; Smith, JE, 2013)
"The effect of phased caffeine withdrawal and abstention on tinnitus severity was assessed using a pseudo-randomized, double-blinded, placebo-controlled crossover trial of 30 days duration."5.14Caffeine abstinence: an ineffective and potentially distressing tinnitus therapy. ( Claire, LS; McKenna, L; Rogers, PJ; Stothart, G, 2010)
"Interruption of daily caffeine consumption can cause caffeine withdrawal headache."5.08Perioperative administration of caffeine tablets for prevention of postoperative headaches. ( Drewe, J; Hampl, KF; Rüttimann, U; Schneider, MC; Ummenhofer, W, 1995)
"To determine whether prophylactic intravenous administration of caffeine, to daily caffeine users, decreases the frequency of postoperative headache and shortens recovery time."5.08Prophylactic intravenous administration of caffeine and recovery after ambulatory surgical procedures. ( Arnold, JJ; Danielson, DR; Ereth, MH; Klindworth, JT; Weber, JG, 1997)
"This report evaluates the scientific literature on caffeine with respect to potential central nervous system (CNS) effects, specifically effects on sleep, anxiety, and aggression/risk-taking."4.93Neurobehavioral hazard identification and characterization for caffeine. ( Mariano, GF; Rodricks, JV; Turnbull, D, 2016)
"We considered only English-language articles published in scientific journals and searched for these articles on PubMed using "headache," "fasting," "Yom Kippur," "Ramadan," "hypoglycemia,"and "caffeine withdrawal" as key words, with no limitations to the year of publication."4.85Fasting headache: a review of the literature and new hypotheses. ( Bini, A; Castellini, P; Evangelista, A; Lambru, G; Manzoni, GC; Torelli, P, 2009)
"Maternal use of "social drugs" such as caffeine, ethanol and tobacco in pregnancy is on increase- -worldwide."4.85Peripartum implications of caffeine intake in pregnancy: is there cause for concern? ( Kuczkowski, KM, 2009)
"Chronic, heavy caffeine ingestion may cause or exacerbate anxiety and may be associated with depression and increased use of antianxiety drugs."4.77Psychotropic effects of caffeine. ( Clementz, GL; Dailey, JW, 1988)
"Daily caffeine intake/kg body weight and caffeine use disorder are significantly associated with a caffeine-withdrawal headache."4.31Prevalence, characteristics, and factors associated with caffeine-withdrawal headache during the first day of Ramadan. ( Al-Azayem, SA; El Desouky, ED; Fathy, W; Hammad, EM; Hussein, M; Magdy, R; Mahfouz, NA; Naguib, EM; Salem, MR, 2023)
"Participants in the Told Caffeine condition reported a significantly greater reduction in the factors of cravings, fatigue, lack of alertness and flu-like feelings of the CWSQ, than those in the Told Decaf condition."3.83Placebo caffeine reduces withdrawal in abstinent coffee drinkers. ( Boakes, RA; Colagiuri, B; Mills, L, 2016)
"Habitual caffeine consumers who abstain from caffeine experience withdrawal symptoms such as headache, fatigue, difficulty concentrating, mood disturbances, and flu-like symptoms (Juliano and Griffiths, 2004)."3.78Development of the caffeine withdrawal symptom questionnaire: caffeine withdrawal symptoms cluster into 7 factors. ( Harrell, PT; Huntley, ED; Juliano, LM; Westerman, AT, 2012)
" Dipyridamole, a blocker of adenosine reuptake, induced a significant reduction of morphine dependence."3.75Functional interaction between purinergic system and opioid withdrawal: in vitro evidence. ( Capasso, A; Gallo, C, 2009)
"To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy."3.73Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005)
"The purpose of the study was to examine whether caffeine dependence and a family history of alcoholism are associated with continued use of caffeine during pregnancy."3.73Caffeine dependence in combination with a family history of alcoholism as a predictor of continued use of caffeine during pregnancy. ( Berger, N; Griffiths, RR; Haug, NA; Svikis, DS, 2005)
"In connection with the Vågå study of headache epidemiology, a search was made for caffeine-withdrawal headache in 1741 parishioners."3.72Caffeine-withdrawal headache. The Vågå study of headache epidemiology. ( Bakketeig, LS; Sjaastad, O, 2004)
"It is believed that adenosine is released in ischemic tissues and contributes to reactive hyperemia."3.70Intravascular source of adenosine during forearm ischemia in humans: implications for reactive hyperemia. ( Angel, M; Biaggioni, I; Cavalcante, J; Christman, B; Costa, F; Haile, V; Sulur, P, 1999)
"The extent to which daily caffeine use is associated with a substance dependence syndrome similar to that associated with other psychoactive drugs is unknown."3.69Caffeine dependence syndrome. Evidence from case histories and experimental evaluations. ( Griffiths, RR; Mumford, GK; Silverman, K; Strain, EC, 1994)
"By the example of two case reports, typical signs of caffeine withdrawal like headache, increased irritability, decreased performance and disturbed concentration are described."3.69[Episodic headache, diminished performance and depressive mood]. ( Cacciatore, R; Helbling, A; Hess, B; Jost, C, 1996)
"Caffeine consumption may cause headache, particularly migraine."3.69Influence of caffeine and caffeine withdrawal on headache and cerebral blood flow velocities. ( Couturier, EG; Laman, DM; van Duijn, H; van Duijn, MA, 1997)
"The interruption of daily consumption of caffeine-containing beverages can cause headache and other symptoms within 8 hours."3.68Perioperative ingestion of caffeine and postoperative headache. ( Danielson, DR; Ereth, MH; Weber, JG, 1993)
"This study examined the hypothesis that headache after general anesthesia is related to a caffeine withdrawal state."3.68Is caffeine withdrawal the mechanism of postoperative headache? ( Fennelly, M; Galletly, DC; Purdie, GI, 1991)
"Lithium tremor worsened in two patients when caffeine (coffee) was eliminated from their diets."3.67Lithium tremor and caffeine intake: two cases of drinking less and shaking more. ( Jefferson, JW, 1988)
"Plasma adenosine concentrations doubled when rats were subjected to 90 min of profound hemorrhagic shock."3.67Endogenous adenosine and hemorrhagic shock: effects of caffeine administration or caffeine withdrawal. ( Conlay, LA; Evoniuk, G; Wurtman, RJ, 1988)
"A review of the recent literature shows the role of caffeine in the physiology, mood, and behavior of persons to be a complex one including changes in arousal, anxiety, and performance."3.66Caffeine and human behavior: arousal, anxiety, and performance effects. ( Julia, HL; Sawyer, DA; Turin, AC, 1982)
"decaf) can reduce caffeine withdrawal symptoms, even when people do not hold a conscious expectancy it will do so."3.30Reduction in caffeine withdrawal after open-label decaffeinated coffee. ( Boakes, R; Colagiuri, B; Lee, JC; Mills, L, 2023)
"Caffeine did not increase alertness in NL participants."2.75Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption. ( Deckert, J; Evershed, RP; Heatherley, SV; Hohoff, C; Maxfield, PJ; Mullings, EL; Nutt, DJ; Rogers, PJ, 2010)
"Caffeine dose was crossed with varying instructions that the coffee would either enhance or impair performance in a 2 x 2 factorial design."2.74Caffeine expectancies influence the subjective and behavioral effects of caffeine. ( Harrell, PT; Juliano, LM, 2009)
"Caffeine was found to have few and modest effects on EEG in the theta and alpha bandwidths, and no effects in the delta and beta bandwidths."2.73Effects of dietary caffeine on topographic EEG after controlling for withdrawal and withdrawal reversal. ( Hogan, MJ; James, JE; Keane, MA, 2007)
"Caffeine is a popular stimulant often used to counter the effects of sleep loss and fatigue."2.73Effects of acute caffeine withdrawal on Short Category Test performance in sleep-deprived individuals. ( Balkin, TJ; Kahn-Greene, ET; Kamimori, GH; Killgore, DB; Killgore, WD, 2007)
"Caffeine deprivation was associated with impaired vigilance performance characterized by a reduction in the percentage of targets detected and an increase in response time, and by subjective reports of decreased vigor and increased fatigue and symptoms characterized by sleepiness, headache, and reduced ability to work."2.69Caffeine deprivation affects vigilance performance and mood. ( Lane, JD; Phillips-Bute, BG, 1998)
"no caffeine) were administered double-blind in novel fruit juice drinks at 10:15, 11:30 and 13:00 h on the test day."2.69Mood and psychomotor performance effects of the first, but not of subsequent, cup-of-coffee equivalent doses of caffeine consumed after overnight caffeine abstinence. ( Robelin, M; Rogers, PJ, 1998)
"A group of those reporting withdrawal symptoms were randomly assigned to three subsamples."2.69The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. ( Curtis, GL; Dews, PB; Hanford, KJ; O'Brien, CP, 1999)
" Adverse events were negligible and did not differ between the CE and PL groups."2.69Safety and efficacy of treatment with an ephedrine/caffeine mixture. The first double-blind placebo-controlled pilot study in adolescents. ( Erhardt, E; Jeges, S; Molnár, D; Török, K, 2000)
"Caffeine deprivation was manipulated by administering capsules containing 0%, 50%, or 100% of each subject's daily caffeine intake (complete, partial, and no deprivation conditions)."2.68Caffeine withdrawal symptoms and self-administration following caffeine deprivation. ( de Wit, H; Mitchell, SH; Zacny, JP, 1995)
""Headache" was significantly correlated with amount of money forfeited to avoid placebo."2.68Caffeine reinforcement: the role of withdrawal. ( Griffiths, RR; Schuh, KJ, 1997)
"Caffeine withdrawal was examined in caffeine-dependent humans living in a residential laboratory."2.68Effects of caffeine withdrawal on humans living in a residential laboratory. ( Comer, SD; Fischman, MW; Foltin, RW; Haney, M, 1997)
"Caffeine deprivation was associated with decreased vigor and increased fatigue and with symptoms including sleepiness and yawning."2.68Caffeine withdrawal symptoms following brief caffeine deprivation. ( Lane, JD; Phillips-Bute, BG, 1997)
"Twenty-two coffee drinkers (three to seven cups per day) underwent repeated double-blind trials to test for caffeine self-administration, withdrawal, and adverse effects."2.67Caffeine self-administration, withdrawal, and adverse effects among coffee drinkers. ( Bickel, WK; Fenwick, JW; Gulliver, SB; Higgins, ST; Hughes, JR; Hunt, WK; Mireault, GC, 1991)
"As most of the population, including migraineurs, consume a considerable amount of caffeine daily, a question arises as to whether it influences their headaches."2.66The Ambiguous Role of Caffeine in Migraine Headache: From Trigger to Treatment. ( Kaźmierczak, W; Nowaczewska, M; Wiciński, M, 2020)
"Caffeine has a synergistic effectiveness with analgesics."2.41Do caffeine-containing analgesics promote dependence? A review and evaluation. ( Dalessio, D; Feinstein, AR; Fox, JM; Goldstein, J; Haag, G; Heinemann, LA; Ladewig, D; O'Brien, CP, 2000)
"Caffeine is an excellent model compound for understanding drugs of abuse/dependence."2.41Caffeine as a model drug of dependence: recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome, and caffeine negative reinforcement. ( Chausmer, AL; Griffiths, RR, 2000)
"There is evidence for caffeine withdrawal symptoms, and caffeine does act as a weak reinforcer, but neither effect is as pronounced as those associated with cocaine."2.40[Is caffeine addictive? The most widely used psychoactive substance in the world affects same parts of the brain as cocaine]. ( Daly, JW; Fredholm, BB; Holmén, J, 1998)
"The effects of caffeine on specific mental illnesses and the medications used to treat them will be discussed."2.39Caffeine and its effect on persons with mental disorders. ( Simmons, DH, 1996)
"Withdrawal symptoms have been documented after relatively short-term exposure to high doses of caffeine (i."2.37Caffeine physical dependence: a review of human and laboratory animal studies. ( Griffiths, RR; Woodson, PP, 1988)
"Caffeine expectancy was associated with reduced subjective withdrawal 30 min following the gum administration but was not significantly impacted by actual caffeine administration."1.72The impacts of caffeine administration, expectancies, and related stimuli on coffee craving, withdrawal, and self-administration. ( Barrett, SP; Shephard, A, 2022)
" Dose-response testing indicated an optimal caffeine concentration of 0."1.56Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior. ( George, O; Kimbrough, A; Lee, CH, 2020)
"We found 16 categories of withdrawal symptoms."1.56Mechanisms for the reduction of caffeine consumption: What, how and why. ( Booth, N; Chung, A; McKean, J; Park, JJ; Rodda, S; Ware, P, 2020)
"Whether acute exercise can reduce withdrawal symptoms also remains unknown."1.51Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal. ( Fagan, MJ; Morava, A; Prapavessis, H, 2019)
"Negative expectancies can exacerbate withdrawal symptoms via the nocebo effect."1.51The effect of dose expectancies on caffeine withdrawal symptoms during tapered dose reduction. ( Boakes, RA; Colagiuri, B; Mills, L, 2019)
"Caffeine was administrated during all prenatal and postnatal life (CAF, 0."1.51Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence. ( Abreu-Villaça, Y; da Silva Gonçalves, B; Filgueiras, CC; Leal-Rocha, PH; Manhães, AC; Ribeiro-Carvalho, A, 2019)
"There were no expectancy effects on withdrawal symptoms or cognitive performance."1.51Investigating the role of expectancy in caffeine withdrawal using the balanced placebo design. ( Edwards, KC; Harrell, PT; Juliano, LM; Kardel, PG; Muench, C, 2019)
"We assessed the seizure vulnerability and anxiety responses following the chronic co-administration of, and withdrawal from, caffeine and ethanol in male rats."1.48Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model. ( Alele, PE; Matovu, D, 2018)
"Caffeine is a common psychoactive substance with a documented addictive potential."1.48Caffeine use disorder: An item-response theory analysis of proposed DSM-5 criteria. ( Ágoston, C; Demetrovics, Z; Richman, MJ; Urbán, R, 2018)
"After 24-hour caffeine abstinence withdrawal symptoms were measured using a self-report caffeine withdrawal scale, and then again after a cup of decaffeinated coffee."1.46Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms. ( Colagiuri, B; Dar-Nimrod, I; Mills, L, 2017)
"Caffeine abstinence was independently associated with an excellent efficacy of acute treatment (multivariate odds ratio, 3."1.43Caffeine discontinuation improves acute migraine treatment: a prospective clinic-based study. ( Choi, H; Choi, HA; Chung, CS; Lee, MJ, 2016)
"Withdrawal of caffeine however produced memory deficits and significantly increases the immobility time of rats in FST."1.38Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats. ( Haider, S; Haleem, DJ; Khaliq, S; Naqvi, F; Perveen, T; Saleem, S, 2012)
"Caffeine treatment seekers (mean age 41 years, 55% women) consumed an average of 548 mg caffeine per day."1.38Characterization of individuals seeking treatment for caffeine dependence. ( Evatt, DP; Griffiths, RR; Juliano, LM; Richards, BD, 2012)
"GAD, phobias, and MDD shared genetic factors with caffeine use, with genetic correlations estimated to be 0."1.38Common psychiatric disorders and caffeine use, tolerance, and withdrawal: an examination of shared genetic and environmental effects. ( Bergin, JE; Kendler, KS, 2012)
"Caffeine is a psychostimulant with intake through foods or beverages tending to increase from childhood through adolescence."1.37Acute and adaptive motor responses to caffeine in adolescent and adult rats. ( Huggler, AL; Rhoads, DE; Rhoads, LJ, 2011)
"The patients suffering from eating disorders reported higher current caffeine intake than those with anxiety or mood disorders."1.36Patterns of caffeine consumption in psychiatric patients. An Italian study. ( Carmassi, C; Ciampa, G; Ciapparelli, A; Consoli, G; Dell'Osso, L; Marazziti, D; Paggini, R; Ramacciotti, CE; Taponecco, C, 2010)
" Caffeine improved alerting and executive control function in a dose-response manner, asymptoting at 200mg; this effect is congruent with caffeine's adenosine-mediated effects on dopamine-rich areas of brain, and the involvement of these areas in alerting and the executive control of visual attention."1.36Caffeine modulates attention network function. ( Brunyé, TT; Lieberman, HR; Mahoney, CR; Taylor, HA, 2010)
"The 14 withdrawal symptoms were grouped into three factors termed "fatigue and headache", "dysphoric mood", and "flu-like somatic"."1.35Fourteen well-described caffeine withdrawal symptoms factor into three clusters. ( Brenner, D; El-Sohemy, A; Ozsungur, S, 2009)
"As for withdrawal symptoms, NCT caused a more intensive degree of irritability than CAF or ALC, and a more intensive degree of difficulty concentrating and restlessness than did withdrawal from ALC."1.35Psychosocial withdrawal characteristics of nicotine compared with alcohol and caffeine. ( Hironaka, N; Miyasato, K; Miyata, H; Nakamura, K; Takada, K; Yanagita, T, 2008)
" Following this repeated caffeine doses were administered to test the claim that repeated dosing has no extra effect on mood or performance."1.34Effects of repeated doses of caffeine on performance and alertness: new data and secondary analyses. ( Hewlett, P; Smith, A, 2007)
"Adenosine reduces opioid withdrawal symptoms by activating A(1) adenosine receptors, probably by inhibiting excitatory amino acid release."1.32Interactive role of adenosine and dopamine in the opiate withdrawal syndrome. ( Berrino, L; Capuano, A; De Novellis, V; Filippelli, A; Mazzeo, F; Rossi, F; Stella, L; Vitelli, MR, 2003)
"Other substance dependence disorders were not overrepresented in the caffeine dependent group compared to the caffeine nondependent group."1.31Caffeine use and dependence in adolescents: one-year follow-up. ( Bernstein, GA; Oberstar, JV; Thuras, PD, 2002)
"In a second model, hyperalgesia was induced by the i."1.31Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. ( Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C, 2002)
"Eight expert substance abuse clinicians agreed with self-endorsed caffeine dependence 91% of the time."1.30Endorsement of DSM-IV dependence criteria among caffeine users. ( Carpenter, J; Howard, T; Hughes, JR; Liguori, A; Oliveto, AH, 1998)
"Caffeine is an addictive psychoactive substance."1.30Caffeine intake, tolerance, and withdrawal in women: a population-based twin study. ( Kendler, KS; Prescott, CA, 1999)
"Caffeine was injected at doses of 80 mg/kg daily for five days."1.2924h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. ( Haleem, DJ; Haleem, MA; Yasmeen, A; Zafar, A, 1995)
" Stimulatory effects of injected caffeine were lower in chronically treated mice and the biphasic dose-response (stimulatory followed by depressant) curve for injected caffeine was left shifted."1.29Locomotor activity in mice during chronic treatment with caffeine and withdrawal. ( Daly, JW; Jacobson, KA; Nikodijević, O, 1993)
"Caffeine has recently undergone scrutiny as a co-morbid risk factor with other substance dependencies, and in other medical and psychiatric conditions."1.29Primary caffeine dependence: a case report. ( Adams, D; Ditzler, T; Haning, WF, 1993)
"The males amongst these were all migraine patients, but 23% of the women suffered from tension-type headache."1.28Weekend attacks in migraine patients: caused by caffeine withdrawal? ( Couturier, EG; Hering, R; Steiner, TJ, 1992)
"Caffeine did not increase the severity of symptoms but did decrease the severity of withdrawal-induced hunger."1.28Effects of caffeine on tobacco withdrawal. ( Bickel, WK; Fenwick, JW; Higgins, ST; Hughes, JR; Oliveto, AH; Pepper, SL; Terry, SY, 1991)
"Mild caffeine deprivation was associated with symptoms of stress."1.28Cardiovascular reactivity, mood, and task performance in deprived and nondeprived coffee drinkers. ( Baum, A; O'Keeffe, MK; Ratliff-Crain, J, 1989)
"Caffeine was contained in at least one drug in all cases, ergotamine in 80."1.28Longterm prognosis of analgesic withdrawal in patients with drug-induced headaches. ( Baumgartner, C; Bingöl, C; Holzner, F; Maly, J; Wessely, P, 1989)
"Caffeine was found to be approximately 10X more active than Na benzoate in inhibiting cAMP phosphodiesterase activity in a neuroblastoma cell whole homogenate assay."1.26Caffeine elicited withdrawal signs in morphine-dependent rhesus monkeys. ( Aceto, MD; Carchman, RA; Flora, RE; Harris, LS, 1978)
"Caffeine 'insomnia' thus seems characterized by increased stability of wakefulness, and hypnotic withdrawal 'insomnia' by decreased stability fo sleep."1.25Two types of insomnia: too much waking or not enough sleep. ( Brezinová, V; Loudon, J; Oswald, I, 1975)

Research

Studies (261)

TimeframeStudies, this research(%)All Research%
pre-199058 (22.22)18.7374
1990's92 (35.25)18.2507
2000's65 (24.90)29.6817
2010's35 (13.41)24.3611
2020's11 (4.21)2.80

Authors

AuthorsStudies
Mills, L4
Lee, JC1
Boakes, R1
Colagiuri, B4
Lin, YS1
Weibel, J1
Landolt, HP1
Santini, F1
Slawik, H1
Borgwardt, S1
Cajochen, C1
Reichert, CF1
Magdy, R1
El Desouky, ED1
Hammad, EM1
Salem, MR1
Mahfouz, NA1
Fathy, W1
Al-Azayem, SA1
Naguib, EM1
Hussein, M1
Martin, EL1
Baker, NL1
Sempio, C1
Christians, U1
Klawitter, J1
McRae-Clark, AL1
Chattha, N1
Webb, T1
Hargroves, D1
Balogun, I1
Bertoni, M1
Morava, A1
Fagan, MJ1
Prapavessis, H1
Lee, CH1
George, O1
Kimbrough, A1
Rodda, S1
Booth, N1
McKean, J1
Chung, A2
Park, JJ1
Ware, P1
Nowaczewska, M1
Wiciński, M1
Kaźmierczak, W1
Bright, M1
Raman, V1
Laupland, KB1
Agritelley, MS1
Goldberger, JJ1
Evans, MJ1
Jenkins, MD1
Berry, JN1
Shephard, A1
Barrett, SP1
Kalladka, D1
Siddiqui, A1
Tyagi, A1
Newman, E1
Dar-Nimrod, I1
Matovu, D1
Alele, PE1
Ágoston, C1
Urbán, R1
Richman, MJ1
Demetrovics, Z1
Boakes, RA2
da Silva Gonçalves, B1
Leal-Rocha, PH1
Manhães, AC1
Filgueiras, CC1
Abreu-Villaça, Y1
Ribeiro-Carvalho, A1
Juliano, LM5
Kardel, PG1
Harrell, PT3
Muench, C1
Edwards, KC1
James, JE9
Patel, G1
Poole, RL1
Braak, D1
Gould, TJ1
Krankl, JT1
Gitlin, M1
Turnbull, D1
Rodricks, JV1
Mariano, GF1
Lee, MJ1
Choi, HA1
Choi, H1
Chung, CS1
Sudakov, SK1
Bogdanova, NG1
Hughes, RN1
Hancock, NJ1
Sacavage, S1
Patel, H1
Zielinski, M1
Acker, J1
Phillips, AG1
Raffa, RB2
Rawls, SM2
Dreumont-Boudreau, SE1
Dingle, RN1
Alcolado, GM1
Lolordo, VM1
Shapiro, RE2
Ozsungur, S1
Brenner, D1
El-Sohemy, A1
Reissig, CJ1
Strain, EC4
Griffiths, RR21
Keane, MA3
Miyata, H1
Hironaka, N1
Takada, K1
Miyasato, K1
Nakamura, K1
Yanagita, T1
Sin, CW1
Ho, JS1
Chung, JW2
Sigmon, SC2
Herning, RI2
Better, W1
Cadet, JL2
Nikić, PM1
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Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparing the Acute Effects of Exercise and Caffeine on Working Memory During a Short Period of Caffeine Deprivation in Moderate to Heavy Caffeine Consumers[NCT05170464]Phase 2/Phase 342 participants (Anticipated)Interventional2022-01-31Not yet recruiting
CaffeinICU Study - A Randomized Controlled Multi-centre Pilot Study, on the Efficacy of Oral Caffeine, in Reducing the Duration of Mechanical Ventilation in Critically Ill Adult Patients[NCT05232734]Phase 230 participants (Anticipated)Interventional2022-11-24Recruiting
Impact of Intravenous Caffeine on Atrial Electrical Properties and Potential Arrythmia Induction in Patients With Paroxysmal Atrial Fibrillation: The COFFEE-AF Trial[NCT05464940]100 participants (Anticipated)Interventional2023-06-30Not yet recruiting
A Randomized, Double Dummy, Double Blind, Placebo Controlled Cross Over Study to Evaluate Efficacy of Investigational Product E-AG-01/ E-AG02/ E-AG-03/ E-AG-04 on Alertness and Mental Fatigue[NCT02816827]59 participants (Actual)Interventional2016-03-31Completed
The Impact of Caffeine on Cognition in Schizophrenia[NCT02832401]24 participants (Actual)Interventional2016-09-02Completed
Weekend Headaches in School-age Children[NCT05218330]100 participants (Anticipated)Observational2022-01-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

33 reviews available for caffeine and Substance Withdrawal Syndrome

ArticleYear
The Ambiguous Role of Caffeine in Migraine Headache: From Trigger to Treatment.
    Nutrients, 2020, Jul-28, Volume: 12, Issue:8

    Topics: Adolescent; Adult; Beverages; Caffeine; Child; Female; Humans; Male; Middle Aged; Migraine Disorders

2020
Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review.
    BMC anesthesiology, 2021, 03-31, Volume: 21, Issue:1

    Topics: Anesthesia Recovery Period; Caffeine; Central Nervous System Stimulants; Critical Care; Headache; Hu

2021
Caffeine supplementation in the hospital: Potential role for the treatment of caffeine withdrawal.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2021, Volume: 153

    Topics: Administration, Oral; Caffeine; Dietary Supplements; Hospitals; Humans; Inpatients; Substance Withdr

2021
Caffeine and cognitive performance: persistent methodological challenges in caffeine research.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 124

    Topics: Caffeine; Cognition; Humans; Substance Withdrawal Syndrome

2014
The management of substance abuse in the critically ill.
    Disease-a-month : DM, 2014, Volume: 60, Issue:8

    Topics: Alcoholic Intoxication; Benzodiazepines; Caffeine; Cocaine-Related Disorders; Critical Illness; Drug

2014
Neurobehavioral hazard identification and characterization for caffeine.
    Regulatory toxicology and pharmacology : RTP, 2016, Volume: 74

    Topics: Aggression; Animals; Anxiety; Caffeine; Central Nervous System; Central Nervous System Stimulants; D

2016
Caffeine and headaches.
    Current pain and headache reports, 2008, Volume: 12, Issue:4

    Topics: Caffeine; Headache; Headache Disorders, Secondary; Humans; Substance Withdrawal Syndrome

2008
Caffeinated energy drinks--a growing problem.
    Drug and alcohol dependence, 2009, Jan-01, Volume: 99, Issue:1-3

    Topics: Advertising; Beverages; Caffeine; Central Nervous System Stimulants; Drug Tolerance; Humans; Legisla

2009
Systematic review on the effectiveness of caffeine abstinence on the quality of sleep.
    Journal of clinical nursing, 2009, Volume: 18, Issue:1

    Topics: Adult; Caffeine; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Patient Complia

2009
Fasting headache: a review of the literature and new hypotheses.
    Headache, 2009, Volume: 49, Issue:5

    Topics: Caffeine; Causality; Fasting; Food Deprivation; Headache; Homeostasis; Humans; Hypoglycemia; Religio

2009
Peripartum implications of caffeine intake in pregnancy: is there cause for concern?
    Revista espanola de anestesiologia y reanimacion, 2009, Volume: 56, Issue:10

    Topics: Abnormalities, Drug-Induced; Adult; Animals; Beverages; Caffeine; Dose-Response Relationship, Drug;

2009
Caffeine at high altitude: java at base cAMP.
    High altitude medicine & biology, 2010,Spring, Volume: 11, Issue:1

    Topics: Acclimatization; Altitude; Altitude Sickness; Beverages; Caffeine; Central Nervous System Stimulants

2010
Caffeine withdrawal, sleepiness, and driving performance: what does the research really tell us?
    Nutritional neuroscience, 2011, Volume: 14, Issue:3

    Topics: Attention; Automobile Driving; Caffeine; Central Nervous System Stimulants; Humans; Narcolepsy; Reac

2011
Caffeine: behavioral effects of withdrawal and related issues.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:9

    Topics: Behavior; Caffeine; Central Nervous System Stimulants; Drug Tolerance; Humans; Substance Withdrawal

2002
A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features.
    Psychopharmacology, 2004, Volume: 176, Issue:1

    Topics: Caffeine; Diagnostic and Statistical Manual of Mental Disorders; Humans; Incidence; Meta-Analysis as

2004
Effects of caffeine on performance and mood: withdrawal reversal is the most plausible explanation.
    Psychopharmacology, 2005, Volume: 182, Issue:1

    Topics: Affect; Arousal; Attention; Caffeine; Central Nervous System Stimulants; Drug Tolerance; Follow-Up S

2005
Is caffeine addictive?--a review of the literature.
    The American journal of drug and alcohol abuse, 2006, Volume: 32, Issue:4

    Topics: Caffeine; Drug Tolerance; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders

2006
Caffeine and headaches.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2007, Volume: 28 Suppl 2

    Topics: Adenosine; Brain; Caffeine; Drug Combinations; Drug Synergism; Headache Disorders; Headache Disorder

2007
Caffeine, sleep and wakefulness: implications of new understanding about withdrawal reversal.
    Human psychopharmacology, 2007, Volume: 22, Issue:8

    Topics: Automobile Driving; Brain; Caffeine; Central Nervous System Stimulants; Electroencephalography; Huma

2007
Caffeine.
    Annual review of nutrition, 1982, Volume: 2

    Topics: Adult; Age Factors; Animals; Behavior, Animal; Birth Weight; Caffeine; Cardiovascular System; Centra

1982
Caffeine dependence: fact or fiction?
    Journal of the Royal Society of Medicine, 1995, Volume: 88, Issue:8

    Topics: Caffeine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders

1995
Caffeine use: is there a net benefit for mood and psychomotor performance?
    Neuropsychobiology, 1995, Volume: 31, Issue:4

    Topics: Affect; Animals; Caffeine; Humans; Psychomotor Performance; Substance Withdrawal Syndrome

1995
Is caffeine involved in the pathogenesis of combat-stress reaction?
    Military medicine, 1996, Volume: 161, Issue:4

    Topics: Caffeine; Central Nervous System Stimulants; Combat Disorders; Humans; Military Personnel; Stress, P

1996
Caffeine and its effect on persons with mental disorders.
    Archives of psychiatric nursing, 1996, Volume: 10, Issue:2

    Topics: Caffeine; Humans; Mental Disorders; Neurocognitive Disorders; Neurologic Examination; Substance With

1996
[Is caffeine addictive? The most widely used psychoactive substance in the world affects same parts of the brain as cocaine].
    Lakartidningen, 1998, Dec-16, Volume: 95, Issue:51-52

    Topics: Adult; Animals; Brain; Caffeine; Central Nervous System Stimulants; Drug Interactions; Humans; Recep

1998
Do caffeine-containing analgesics promote dependence? A review and evaluation.
    Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:5

    Topics: Analgesics; Caffeine; Drug Synergism; Evidence-Based Medicine; Headache; Humans; Phenacetin; Substan

2000
Caffeine as a model drug of dependence: recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome, and caffeine negative reinforcement.
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2000, Volume: 20, Issue:5

    Topics: Adolescent; Adult; Caffeine; Child; Humans; Models, Biological; Reinforcement, Psychology; Substance

2000
Physiologic and psychotropic effects of caffeine on man. A review.
    Journal of the American Dietetic Association, 1977, Volume: 71, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Attention Deficit Disorder with Hyperactivity; Cacao; Caffeine

1977
Possible psychiatric significance of excessive coffee consumption.
    Canadian Psychiatric Association journal, 1975, Volume: 20, Issue:8

    Topics: Adult; Anxiety Disorders; Blood Pressure; Caffeine; Canada; Cardiovascular System; Cerebrovascular C

1975
Should caffeine abuse, dependence, or withdrawal be added to DSM-IV and ICD-10?
    The American journal of psychiatry, 1992, Volume: 149, Issue:1

    Topics: Caffeine; Coffee; Humans; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Substance

1992
Caffeine physical dependence: a review of human and laboratory animal studies.
    Psychopharmacology, 1988, Volume: 94, Issue:4

    Topics: Animals; Caffeine; Humans; Risk Factors; Substance Withdrawal Syndrome; Substance-Related Disorders

1988
Psychotropic effects of caffeine.
    American family physician, 1988, Volume: 37, Issue:5

    Topics: Affect; Anxiety; Behavior; Caffeine; Depression; Dose-Response Relationship, Drug; Female; Food Anal

1988
Propoxyphene hydrochloride. A critical review.
    JAMA, 1970, Aug-10, Volume: 213, Issue:6

    Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headac

1970

Trials

64 trials available for caffeine and Substance Withdrawal Syndrome

ArticleYear
Reduction in caffeine withdrawal after open-label decaffeinated coffee.
    Journal of psychopharmacology (Oxford, England), 2023, Volume: 37, Issue:2

    Topics: Alcoholic Intoxication; Caffeine; Coffee; Humans; Psychotropic Drugs; Substance Withdrawal Syndrome;

2023
Brain activity during a working memory task after daily caffeine intake and caffeine withdrawal: a randomized double-blind placebo-controlled trial.
    Scientific reports, 2023, 01-18, Volume: 13, Issue:1

    Topics: Adult; Brain; Caffeine; Cerebral Cortex; Cross-Over Studies; Double-Blind Method; Humans; Memory, Sh

2023
Effects of dietary caffeine on EEG, performance and mood when rested and sleep restricted.
    Human psychopharmacology, 2008, Volume: 23, Issue:8

    Topics: Adolescent; Affect; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Diet; Electroen

2008
Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects.
    Psychopharmacology, 2009, Volume: 204, Issue:4

    Topics: Adult; Anterior Cerebral Artery; Caffeine; Central Nervous System Stimulants; Cerebrovascular Circul

2009
Caffeine expectancies influence the subjective and behavioral effects of caffeine.
    Psychopharmacology, 2009, Volume: 207, Issue:2

    Topics: Affect; Attention; Caffeine; Central Nervous System Stimulants; Coffee; Double-Blind Method; Female;

2009
Caffeine abstinence: an ineffective and potentially distressing tinnitus therapy.
    International journal of audiology, 2010, Volume: 49, Issue:1

    Topics: Adult; Aged; Caffeine; Central Nervous System Stimulants; Coffee; Cross-Over Studies; Double-Blind M

2010
Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:9

    Topics: Adult; Anxiety; Arousal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Dr

2010
Acute effects of caffeine on attention: a comparison of non-consumers and withdrawn consumers.
    Journal of psychopharmacology (Oxford, England), 2013, Volume: 27, Issue:1

    Topics: Adolescent; Adult; Attention; Beverages; Caffeine; Cognition; Double-Blind Method; Female; Humans; M

2013
Faster but not smarter: effects of caffeine and caffeine withdrawal on alertness and performance.
    Psychopharmacology, 2013, Volume: 226, Issue:2

    Topics: Adolescent; Adult; Anxiety; Caffeine; Central Nervous System Stimulants; Cognition; Computers; Dose-

2013
Oral caffeine maintenance potentiates the reinforcing and stimulant subjective effects of intravenous nicotine in cigarette smokers.
    Psychopharmacology, 2003, Volume: 165, Issue:3

    Topics: Administration, Oral; Adult; Caffeine; Central Nervous System Stimulants; Cocaine-Related Disorders;

2003
Topographic quantitative EEG response to acute caffeine withdrawal: a comprehensive analysis of multiple quantitative variables.
    Clinical EEG (electroencephalography), 2002, Volume: 33, Issue:4

    Topics: Adolescent; Adult; Alpha Rhythm; Analysis of Variance; Beta Rhythm; Brain Mapping; Caffeine; Cerebra

2002
Attenuated adrenocortical and blood pressure responses to psychological stress in ad libitum and abstinent smokers.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 74, Issue:2

    Topics: Adrenal Cortex; Adult; Affect; Blood Pressure; Caffeine; Central Nervous System Stimulants; Cotinine

2003
Transdermal nicotine maintenance attenuates the subjective and reinforcing effects of intravenous nicotine, but not cocaine or caffeine, in cigarette-smoking stimulant abusers.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:5

    Topics: Administration, Cutaneous; Adult; Blood Pressure; Caffeine; Central Nervous System Stimulants; Cocai

2004
Effects of dietary caffeine on mood when rested and sleep restricted.
    Human psychopharmacology, 2004, Volume: 19, Issue:5

    Topics: Adolescent; Adult; Affect; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Diet; Do

2004
How habitual caffeine consumption and dose influence flavour preference conditioning with caffeine.
    Physiology & behavior, 2004, Sep-15, Volume: 82, Issue:2-3

    Topics: Adult; Association Learning; Caffeine; Central Nervous System Stimulants; Choice Behavior; Condition

2004
Effects of caffeine in non-withdrawn volunteers.
    Human psychopharmacology, 2005, Volume: 20, Issue:1

    Topics: Activity Cycles; Adult; Affect; Attention; Caffeine; Drug Administration Schedule; Human Experimenta

2005
Cognitive and psychomotor performance, mood, and pressor effects of caffeine after 4, 6 and 8 h caffeine abstinence.
    Psychopharmacology, 2005, Volume: 178, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Affect; Blood Pressure; Caffeine; Central Nervous System St

2005
Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction.
    Psychopharmacology, 2005, Volume: 179, Issue:4

    Topics: Adult; Affect; Attention; Blood Pressure; Caffeine; Central Nervous System Stimulants; Chromatograph

2005
Caffeine deprivation state modulates coffee consumption but not attentional bias for caffeine-related stimuli.
    Behavioural pharmacology, 2005, Volume: 16, Issue:7

    Topics: Adolescent; Adult; Affect; Attention; Caffeine; Central Nervous System Stimulants; Coffee; Cognition

2005
Psychostimulant and other effects of caffeine in 9- to 11-year-old children.
    Journal of child psychology and psychiatry, and allied disciplines, 2006, Volume: 47, Issue:2

    Topics: Affect; Arousal; Attention; Caffeine; Central Nervous System Stimulants; Child; Cognition; Dose-Resp

2006
Acute effects of caffeine in volunteers with different patterns of regular consumption.
    Human psychopharmacology, 2006, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Affect; Aged; Analysis of Variance; Caffeine; Central Nervous System Stimulants;

2006
Effects of dietary caffeine on topographic EEG after controlling for withdrawal and withdrawal reversal.
    Neuropsychobiology, 2007, Volume: 56, Issue:4

    Topics: Adolescent; Adult; Affect; Analysis of Variance; Attention; Brain Mapping; Caffeine; Central Nervous

2007
Effects of acute caffeine withdrawal on Short Category Test performance in sleep-deprived individuals.
    Perceptual and motor skills, 2007, Volume: 105, Issue:3 Pt 2

    Topics: Adult; Caffeine; Cognition Disorders; Concept Formation; Double-Blind Method; Drug Combinations; Eth

2007
Coffee: should we stop drinking it?
    Lancet (London, England), 1981, Jan-31, Volume: 1, Issue:8214

    Topics: Caffeine; Clinical Trials as Topic; Coffee; Humans; Substance Withdrawal Syndrome; Substance-Related

1981
Anxiety and muscle tension as consequences of caffeine withdrawal.
    Science (New York, N.Y.), 1980, Sep-26, Volume: 209, Issue:4464

    Topics: Adult; Anxiety; Caffeine; Humans; Muscle Contraction; Substance Withdrawal Syndrome

1980
Perioperative administration of caffeine tablets for prevention of postoperative headaches.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:9

    Topics: Adult; Aged; Caffeine; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged; Postoperati

1995
Effects of caffeine deprivation on complex human functioning.
    Psychopharmacology, 1995, Volume: 118, Issue:4

    Topics: Adult; Blood Pressure; Caffeine; Cross-Over Studies; Double-Blind Method; Female; Heart Rate; Humans

1995
Caffeine withdrawal symptoms and self-administration following caffeine deprivation.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 51, Issue:4

    Topics: Adult; Caffeine; Coffee; Female; Humans; Male; Psychomotor Performance; Reinforcement Schedule; Self

1995
Cardiovascular, behavioral, and subjective effects of caffeine under field conditions.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:4

    Topics: Adult; Arousal; Behavior; Blood Pressure; Caffeine; Female; Headache; Heart Rate; Hemodynamics; Huma

1994
Effects of acute caffeine withdrawal on habituated male runners.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 76, Issue:3

    Topics: Adult; Anaerobic Threshold; Caffeine; Carbohydrate Metabolism; Double-Blind Method; Exercise; Fats;

1994
Caffeine antagonizes EEG effects of tobacco withdrawal.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:4

    Topics: Adult; Affect; Blood Pressure; Caffeine; Coffee; Drug Interactions; Electroencephalography; Heart Ra

1994
The acute and chronic effects of ephedrine/caffeine mixtures on energy expenditure and glucose metabolism in humans.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1993, Volume: 17 Suppl 3

    Topics: Adult; Blood Glucose; Caffeine; Double-Blind Method; Drug Therapy, Combination; Energy Metabolism; E

1993
Caffeine metabolism and epinephrine responses during exercise in users and nonusers.
    Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 75, Issue:2

    Topics: Adult; Blood Glucose; Caffeine; Catecholamines; Epinephrine; Exercise; Fatty Acids, Nonesterified; G

1993
Blood pressure, plasma catecholamine and renin responses to caffeine in elderly hypertensives.
    Journal of human hypertension, 1993, Volume: 7, Issue:3

    Topics: Aged; Aged, 80 and over; Blood Pressure; Caffeine; Catecholamines; Double-Blind Method; Female; Huma

1993
Caffeine self-administration and withdrawal: incidence, individual differences and interrelationships.
    Drug and alcohol dependence, 1993, Volume: 32, Issue:3

    Topics: Adult; Arousal; Caffeine; Coffee; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hum

1993
Mood and performance effects of caffeine in relation to acute and chronic caffeine deprivation.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Affect; Anger; Caffeine; Central Nervous System Stimulants; Chroni

1995
The effect of caffeine on cue exposure responses in ex-smokers.
    Addiction (Abingdon, England), 1996, Volume: 91, Issue:2

    Topics: Adult; Arousal; Caffeine; Cues; Female; Humans; Male; Single-Blind Method; Smoking Cessation; Substa

1996
Caffeine reinforcement: the role of withdrawal.
    Psychopharmacology, 1997, Volume: 130, Issue:4

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Female; Headache; Humans; M

1997
Prophylactic intravenous administration of caffeine and recovery after ambulatory surgical procedures.
    Mayo Clinic proceedings, 1997, Volume: 72, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Caffeine; Central Nervous System Stimulants; Coffee; Dou

1997
Effects of brief caffeinated-beverage deprivation on mood, symptoms, and psychomotor performance.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:1

    Topics: Adult; Affect; Beverages; Caffeine; Central Nervous System Stimulants; Cognition; Fatigue; Female; H

1997
Somatic dysfunction increase during caffeine withdrawal.
    The Journal of the American Osteopathic Association, 1997, Volume: 97, Issue:8

    Topics: Adult; Analysis of Variance; Caffeine; Central Nervous System Stimulants; Electroencephalography; Fe

1997
Absorption and subjective effects of caffeine from coffee, cola and capsules.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:3

    Topics: Adult; Affect; Area Under Curve; Behavior; Caffeine; Capsules; Carbonated Beverages; Central Nervous

1997
Caffeine dependence in schoolchildren?
    Experimental and clinical psychopharmacology, 1997, Volume: 5, Issue:4

    Topics: Affect; Caffeine; Central Nervous System Stimulants; Child; Female; Humans; Male; Substance Withdraw

1997
Effects of caffeine withdrawal on humans living in a residential laboratory.
    Experimental and clinical psychopharmacology, 1997, Volume: 5, Issue:4

    Topics: Adult; Affect; Caffeine; Central Nervous System Stimulants; Eating; Female; Humans; Male; Psychomoto

1997
Caffeine withdrawal symptoms following brief caffeine deprivation.
    Physiology & behavior, 1997, Dec-31, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Affect; Blood Pressure; Caffeine; Central Nervous System Stimulants; Double-Blind

1997
Acute and chronic effects of caffeine on performance, mood, headache, and sleep.
    Neuropsychobiology, 1998, Volume: 38, Issue:1

    Topics: Acute Disease; Affect; Analysis of Variance; Caffeine; Chi-Square Distribution; Chronic Disease; Cro

1998
Physical dependence increases the relative reinforcing effects of caffeine versus placebo.
    Psychopharmacology, 1998, Volume: 139, Issue:3

    Topics: Adult; Analysis of Variance; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double

1998
Caffeine deprivation affects vigilance performance and mood.
    Physiology & behavior, 1998, Volume: 65, Issue:1

    Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Cross-Over Studies;

1998
Mood and psychomotor performance effects of the first, but not of subsequent, cup-of-coffee equivalent doses of caffeine consumed after overnight caffeine abstinence.
    Behavioural pharmacology, 1998, Volume: 9, Issue:7

    Topics: Adolescent; Adult; Affect; Attention; Body Weight; Caffeine; Central Nervous System Stimulants; Coff

1998
Caffeine withdrawal: a parametric analysis of caffeine dosing conditions.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Cluster Analysis; Diet; Double-Blind Method; Fem

1999
The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment.
    Journal of clinical pharmacology, 1999, Volume: 39, Issue:12

    Topics: Adult; Affect; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Female; Health Surv

1999
A controlled study of flumazenil-precipitated withdrawal in chronic low-dose benzodiazepine users.
    Psychopharmacology, 1999, Volume: 147, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Central Nervous System Stimulants; Double-Bli

1999
Caffeine withdrawal increases cerebral blood flow velocity and alters quantitative electroencephalography (EEG) activity.
    Psychopharmacology, 2000, Volume: 147, Issue:4

    Topics: Adult; Affect; Anterior Cerebral Artery; Caffeine; Central Nervous System Stimulants; Cerebrovascula

2000
Effects of caffeine on sensorimotor gating of the startle reflex in normal control subjects: impact of caffeine intake and withdrawal.
    Psychopharmacology, 2000, Volume: 151, Issue:4

    Topics: Adolescent; Adult; Blood Pressure; Caffeine; Double-Blind Method; Heart Rate; Humans; Male; Reflex;

2000
Safety and efficacy of treatment with an ephedrine/caffeine mixture. The first double-blind placebo-controlled pilot study in adolescents.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2000, Volume: 24, Issue:12

    Topics: Adipose Tissue; Adolescent; Apolipoproteins B; Blood Pressure; Body Composition; Caffeine; Double-Bl

2000
Caffeine use as a model of acute and chronic insomnia.
    Sleep, 1992, Volume: 15, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Arousal; Attention; Caffeine; Chronic Disease; Circadian Rhythm; D

1992
Withdrawal syndrome after the double-blind cessation of caffeine consumption.
    The New England journal of medicine, 1992, Oct-15, Volume: 327, Issue:16

    Topics: Adult; Caffeine; Depression; Diet; Double-Blind Method; Female; Headache; Humans; Interview, Psychol

1992
Abrupt outpatient withdrawal of medication in analgesic-abusing migraineurs.
    Lancet (London, England), 1991, Jun-15, Volume: 337, Issue:8755

    Topics: Adult; Amitriptyline; Analgesics; Caffeine; Ergotamine; Evaluation Studies as Topic; Female; Follow-

1991
Caffeine self-administration, withdrawal, and adverse effects among coffee drinkers.
    Archives of general psychiatry, 1991, Volume: 48, Issue:7

    Topics: Adult; Caffeine; Coffee; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged; Self Medi

1991
Low-dose caffeine physical dependence in humans.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3

    Topics: Adult; Affect; Behavior; Caffeine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Admin

1990
Physical dependence on and toxicity from caffeine.
    NIDA research monograph, 1989, Volume: 95

    Topics: Arousal; Caffeine; Coffee; Double-Blind Method; Humans; Randomized Controlled Trials as Topic; Subst

1989
The effects of caffeine on caffeine users and non-users.
    Physiology & behavior, 1986, Volume: 37, Issue:3

    Topics: Adult; Affect; Blood Pressure; Caffeine; Humans; Kinetics; Male; Middle Aged; Movement; Psychomotor

1986
Human coffee drinking: reinforcing and physical dependence producing effects of caffeine.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:2

    Topics: Adult; Caffeine; Coffee; Drinking; Emotions; Headache; Humans; Male; Middle Aged; Psychomotor Perfor

1986
Propoxyphene hydrochloride. A critical review.
    JAMA, 1970, Aug-10, Volume: 213, Issue:6

    Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headac

1970

Other Studies

165 other studies available for caffeine and Substance Withdrawal Syndrome

ArticleYear
Prevalence, characteristics, and factors associated with caffeine-withdrawal headache during the first day of Ramadan.
    Headache, 2023, Volume: 63, Issue:3

    Topics: Body Weight; Caffeine; Cross-Sectional Studies; Headache; Humans; Prevalence; Substance Withdrawal S

2023
Sex differences in endocannabinoid tone in a pilot study of cannabis use disorder and acute cannabis abstinence.
    Addiction biology, 2023, Volume: 28, Issue:10

    Topics: Adult; Caffeine; Cannabinoid Receptor Agonists; Cannabis; Endocannabinoids; Female; Humans; Male; Ma

2023
Reversible cerebral vasoconstriction syndrome after sudden caffeine withdrawal.
    British journal of hospital medicine (London, England : 2005), 2019, Dec-02, Volume: 80, Issue:12

    Topics: Caffeine; Central Nervous System Stimulants; Cerebral Angiography; Cerebral Hemorrhage; Computed Tom

2019
Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal.
    Scientific reports, 2019, 12-23, Volume: 9, Issue:1

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Exercise; Female; Humans; Male; Memory, Short-Te

2019
Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 191

    Topics: Animals; Behavior, Addictive; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Choice

2020
Mechanisms for the reduction of caffeine consumption: What, how and why.
    Drug and alcohol dependence, 2020, 07-01, Volume: 212

    Topics: Adult; Caffeine; Coffee; Databases, Factual; Fatigue; Female; Humans; Male; Substance Withdrawal Syn

2020
Low but not moderate amounts of caffeine increase co-consumption of ethanol in C57BL/6J mice.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 208

    Topics: Alcohol Drinking; Animals; Anxiety; Behavior, Animal; Binge Drinking; Caffeine; Disease Models, Anim

2021
The impacts of caffeine administration, expectancies, and related stimuli on coffee craving, withdrawal, and self-administration.
    Journal of psychopharmacology (Oxford, England), 2022, Volume: 36, Issue:3

    Topics: Caffeine; Coffee; Craving; Cues; Female; Humans; Male; Self Administration; Substance Withdrawal Syn

2022
Reversible cerebral vasoconstriction syndrome secondary to caffeine withdrawal.
    Scottish medical journal, 2018, Volume: 63, Issue:1

    Topics: Adult; Brain; Caffeine; Cerebral Arteries; Coffee; Energy Drinks; Headache Disorders, Primary; Human

2018
Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms.
    Scientific reports, 2017, 08-21, Volume: 7, Issue:1

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Coffee; Female; Humans; Male; Middle Aged; Self

2017
Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model.
    Journal of basic and clinical physiology and pharmacology, 2018, Jan-26, Volume: 29, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Ethanol; Male; Pentylenetetrazole; Rats; Rats, Sprague

2018
Caffeine use disorder: An item-response theory analysis of proposed DSM-5 criteria.
    Addictive behaviors, 2018, Volume: 81

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Cigarette Smoking; Craving; Cross-Sectional Stud

2018
The effect of dose expectancies on caffeine withdrawal symptoms during tapered dose reduction.
    Journal of psychopharmacology (Oxford, England), 2019, Volume: 33, Issue:8

    Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Female; Humans; Male; Psychotropic D

2019
Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence.
    Neuroscience letters, 2019, 03-23, Volume: 696

    Topics: Aging; Animals; Anxiety; Behavior, Animal; Caffeine; Cotinine; Exploratory Behavior; Female; Male; M

2019
Investigating the role of expectancy in caffeine withdrawal using the balanced placebo design.
    Human psychopharmacology, 2019, Volume: 34, Issue:2

    Topics: Adolescent; Adult; Anticipation, Psychological; Caffeine; Central Nervous System Stimulants; Coffee;

2019
Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice.
    Behavioural brain research, 2016, Feb-01, Volume: 298, Issue:Pt A

    Topics: Aging; Animals; Anxiety; Caffeine; Central Nervous System Stimulants; Conditioning, Psychological; D

2016
Caffeine-induced mania in a patient with caffeine use disorder: A case report.
    The American journal on addictions, 2015, Volume: 24, Issue:4

    Topics: Aged; Bipolar Disorder; Caffeine; Comorbidity; Dose-Response Relationship, Drug; Energy Drinks; Huma

2015
Placebo caffeine reduces withdrawal in abstinent coffee drinkers.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:4

    Topics: Adult; Attention; Caffeine; Coffee; Craving; Eating; Fatigue; Female; Food; Humans; Male; Psychomoto

2016
Caffeine discontinuation improves acute migraine treatment: a prospective clinic-based study.
    The journal of headache and pain, 2016, Volume: 17, Issue:1

    Topics: Adult; Caffeine; Coffee; Female; Follow-Up Studies; Humans; Male; Middle Aged; Migraine Disorders; O

2016
Activation of Peripheral κ-Opioid Receptors Normalizes Caffeine Effects Modified in Nicotine-Dependent Rats during Nicotine Withdrawal.
    Bulletin of experimental biology and medicine, 2016, Volume: 161, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Gastric

2016
Effects of acute caffeine on anxiety-related behavior in rats chronically exposed to the drug, with some evidence of possible withdrawal-reversal.
    Behavioural brain research, 2017, 03-15, Volume: 321

    Topics: Animals; Anxiety; Caffeine; Central Nervous System Stimulants; Exploratory Behavior; Female; Male; M

2017
Withdrawal-like behavior in planarians is dependent on drug exposure duration.
    Neuroscience letters, 2008, Jul-04, Volume: 439, Issue:1

    Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inh

2008
Conditioned flavor avoidance as a measure of withdrawal in rats chronically exposed to a caffeine solution.
    Physiology & behavior, 2008, Sep-03, Volume: 95, Issue:1-2

    Topics: Administration, Oral; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Central Nervous Syste

2008
Fourteen well-described caffeine withdrawal symptoms factor into three clusters.
    Psychopharmacology, 2009, Volume: 201, Issue:4

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Female; Humans; Likelihood Functions; Male; Odds

2009
Psychosocial withdrawal characteristics of nicotine compared with alcohol and caffeine.
    Annals of the New York Academy of Sciences, 2008, Volume: 1139

    Topics: Adult; Aged; Behavior, Addictive; Blood Pressure; Caffeine; Central Nervous System Depressants; Cent

2008
Caffeine-withdrawal headache induced by hemodialysis.
    The journal of headache and pain, 2009, Volume: 10, Issue:4

    Topics: Caffeine; Central Nervous System Stimulants; Cerebrovascular Circulation; Coffee; Disease Progressio

2009
Functional interaction between purinergic system and opioid withdrawal: in vitro evidence.
    Current drug safety, 2009, Volume: 4, Issue:2

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor

2009
Caffeine in pregnancy: a cause for concern?
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:6

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Caffeine; Central Nervous System Stimulants; F

2009
Patterns of caffeine consumption in psychiatric patients. An Italian study.
    European psychiatry : the journal of the Association of European Psychiatrists, 2010, Volume: 25, Issue:4

    Topics: Adult; Age Factors; Caffeine; Central Nervous System Stimulants; Comorbidity; Feeding and Eating Dis

2010
Caffeine modulates attention network function.
    Brain and cognition, 2010, Volume: 72, Issue:2

    Topics: Affect; Attention; Caffeine; Central Nervous System Stimulants; Cues; Dose-Response Relationship, Dr

2010
Caffeine expectancy: instrument development in the Rasch measurement framework.
    Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2009, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Culture; Female; Hu

2009
A comparison of the effects of caffeine following abstinence and normal caffeine use.
    Psychopharmacology, 2009, Volume: 207, Issue:3

    Topics: Adult; Affect; Attention; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, D

2009
Modeling withdrawal syndrome in zebrafish.
    Behavioural brain research, 2010, Apr-02, Volume: 208, Issue:2

    Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Diazepam; Disease Models, Animal; Ethanol; Exploratory

2010
The potential dangers of caffeine in pregnancy.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:4

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Caffeine; Central Nervous System Stimulants; C

2010
First evidence that drugs of abuse produce behavioral sensitization and cross sensitization in planarians.
    Behavioural pharmacology, 2010, Volume: 21, Issue:4

    Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Cocaine; Dose-Response Relat

2010
Acute and adaptive motor responses to caffeine in adolescent and adult rats.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:1

    Topics: Adaptation, Physiological; Age Factors; Animals; Caffeine; Dose-Response Relationship, Drug; Male; M

2011
Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats.
    Pakistan journal of pharmaceutical sciences, 2012, Volume: 25, Issue:1

    Topics: Animals; Brain; Caffeine; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Immo

2012
Development of the caffeine withdrawal symptom questionnaire: caffeine withdrawal symptoms cluster into 7 factors.
    Drug and alcohol dependence, 2012, Aug-01, Volume: 124, Issue:3

    Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Cluster Analysis; Coffee; Fatigue; Female; Headache; H

2012
Characterization of individuals seeking treatment for caffeine dependence.
    Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2012, Volume: 26, Issue:4

    Topics: Adult; Anxiety; Caffeine; Coffee; Female; Humans; Male; Middle Aged; Sleep Wake Disorders; Substance

2012
Common psychiatric disorders and caffeine use, tolerance, and withdrawal: an examination of shared genetic and environmental effects.
    Twin research and human genetics : the official journal of the International Society for Twin Studies, 2012, Volume: 15, Issue:4

    Topics: Adult; Anorexia Nervosa; Anxiety Disorders; Bulimia; Caffeine; Depressive Disorder, Major; Diseases

2012
The effects of caffeine abstinence on sleep: a pilot study.
    Applied nursing research : ANR, 2013, Volume: 26, Issue:2

    Topics: Adult; Caffeine; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Pilot Projects; Slee

2013
Caffeine withdrawal: a model for migraine?
    Headache, 2002, Volume: 42, Issue:6

    Topics: Caffeine; Headache; Humans; Models, Biological; Substance Withdrawal Syndrome

2002
Caffeine use and dependence in adolescents: one-year follow-up.
    Journal of child and adolescent psychopharmacology, 2002,Summer, Volume: 12, Issue:2

    Topics: Adolescent; Analysis of Variance; Caffeine; Chi-Square Distribution; Female; Follow-Up Studies; Huma

2002
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine.
    Pharmacological research, 2002, Volume: 46, Issue:3

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Dopamine Antagonists; Drug

2002
Absence of reinforcing, mood and psychomotor performance effects of caffeine in habitual non-consumers of caffeine.
    Psychopharmacology, 2003, Volume: 167, Issue:1

    Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Coffee; Female; Hum

2003
Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 368, Issue:2

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Chr

2003
Caffeine and coffee tolerance.
    Circulation, 2003, Aug-12, Volume: 108, Issue:6

    Topics: Adenosine; Baroreflex; Blood Pressure; Caffeine; Coffee; Drug Tolerance; Heart Rate; Humans; Hyperte

2003
WAKEFULNESS CAUSED BY CAFFEINE.
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1964, May-25, Volume: 248

    Topics: Biomedical Research; Caffeine; Headache; Humans; Lactose; Pharmacology; Sleep; Sleep Wake Disorders;

1964
Caffeine-withdrawal headache. The Vågå study of headache epidemiology.
    Cephalalgia : an international journal of headache, 2004, Volume: 24, Issue:4

    Topics: Adolescent; Adult; Aged; Caffeine; Central Nervous System Stimulants; Coffee; Denmark; Female; Heada

2004
Caffeine withdrawal syndrome in social interaction test in mice: effects of the NMDA receptor channel blockers, memantine and neramexane.
    Behavioural pharmacology, 2004, Volume: 15, Issue:3

    Topics: Animals; Caffeine; Cyclopentanes; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Mal

2004
Barbiturate withdrawal following Internet purchase of Fioricet.
    Archives of neurology, 2004, Volume: 61, Issue:7

    Topics: Acetaminophen; Adult; Barbiturates; Caffeine; Drug Combinations; Female; Humans; Internet; Substance

2004
[Alimentary trigger factors that provoke migraine and tension-type headache].
    Schmerz (Berlin, Germany), 2006, Volume: 20, Issue:2

    Topics: Cacao; Caffeine; Dehydration; Digestive System Diseases; Humans; Migraine Disorders; Substance Withd

2006
Dietary caffeine, performance and mood: enhancing and restorative effects after controlling for withdrawal reversal.
    Neuropsychobiology, 2005, Volume: 52, Issue:1

    Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Diet; Female; Human

2005
Attentional bias for caffeine-related stimuli in high but not moderate or non-caffeine consumers.
    Psychopharmacology, 2005, Volume: 181, Issue:3

    Topics: Adolescent; Adult; Affect; Attention; Caffeine; Cues; Dose-Response Relationship, Drug; Female; Huma

2005
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats.
    Epilepsia, 2005, Volume: 46, Issue:9

    Topics: Adenosine; Animals; Caffeine; Coffea; Disease Models, Animal; Dose-Response Relationship, Drug; Drin

2005
What are caffeine's psychological benefits and risks?
    The Harvard mental health letter, 2005, Volume: 22, Issue:3

    Topics: Caffeine; Central Nervous System Stimulants; Humans; Sleep; Sleep Deprivation; Substance Withdrawal

2005
Caffeine dependence in combination with a family history of alcoholism as a predictor of continued use of caffeine during pregnancy.
    The American journal of psychiatry, 2005, Volume: 162, Issue:12

    Topics: Adult; Alcoholism; Behavior, Addictive; Caffeine; Coffee; Comorbidity; Family Health; Female; Humans

2005
Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice.
    Psychopharmacology, 2006, Volume: 185, Issue:2

    Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Corpus Stri

2006
Effects of repeated doses of caffeine on performance and alertness: new data and secondary analyses.
    Human psychopharmacology, 2007, Volume: 22, Issue:6

    Topics: Adult; Affect; Analysis of Variance; Arousal; Attention; Caffeine; Central Nervous System Stimulants

2007
Seizures in a night club.
    Lancet (London, England), 2007, Jul-21, Volume: 370, Issue:9583

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Beverages; Caffeine; Drug Interactions

2007
Improvement from treatment-resistant schizoaffective disorder, manic type after stopping heavy caffeine intake: a case report.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, Jul-01, Volume: 32, Issue:5

    Topics: Bipolar Disorder; Caffeine; Central Nervous System Stimulants; Humans; Male; Middle Aged; Psychotic

2008
CNS stimulants and the look-alike drugs.
    The Psychiatric clinics of North America, 1984, Volume: 7, Issue:4

    Topics: Amphetamine; Caffeine; Central Nervous System Stimulants; Depressive Disorder; Ephedrine; Humans; Il

1984
Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines.
    Federation proceedings, 1981, Volume: 40, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Huma

1981
Effects of caffeine withdrawal on isoproterenol-stimulated cyclic adenosine monophosphate.
    Clinical pharmacology and therapeutics, 1981, Volume: 30, Issue:4

    Topics: Adrenal Medulla; Adult; Alprostadil; Caffeine; Cyclic AMP; Drug Tolerance; Humans; In Vitro Techniqu

1981
Caffeine: psychiatric grounds for concern.
    Journal of psychosocial nursing and mental health services, 1983, Volume: 21, Issue:8

    Topics: Caffeine; Cerebral Cortex; Humans; Psychotropic Drugs; Stimulation, Chemical; Substance Withdrawal S

1983
Lethargy, anxiety, and impotence in a diabetic.
    Hospital practice (Office ed.), 1982, Volume: 17, Issue:8

    Topics: Adult; Anxiety; Caffeine; Diabetes Complications; Diabetes Mellitus; Erectile Dysfunction; Humans; H

1982
Relevance of caffeine symptomatology to alcohol rehabilitation efforts.
    U. S. Navy medicine, 1980, Volume: 71, Issue:10

    Topics: Adult; Alcoholism; Beverages; Caffeine; Evaluation Studies as Topic; Female; Humans; Male; Middle Ag

1980
Apnea associated with theophylline withdrawal in a term neonate.
    American journal of diseases of children (1960), 1982, Volume: 136, Issue:1

    Topics: Apnea; Caffeine; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange

1982
Caffeine and human behavior: arousal, anxiety, and performance effects.
    Journal of behavioral medicine, 1982, Volume: 5, Issue:4

    Topics: Achievement; Anxiety; Arousal; Caffeine; Cerebral Cortex; Humans; Substance Withdrawal Syndrome

1982
Caffeinism: subjective quantitative aspect of withdrawal syndrome.
    The Medical journal of Australia, 1981, Feb-07, Volume: 1, Issue:3

    Topics: Adult; Caffeine; Humans; Male; Substance Withdrawal Syndrome

1981
Headache.
    The New England journal of medicine, 1980, Jul-24, Volume: 303, Issue:4

    Topics: Caffeine; Headache; Humans; Substance Withdrawal Syndrome

1980
Caffeine-withdrawal headache: a clinical profile.
    Psychosomatics, 1980, Volume: 21, Issue:5

    Topics: Adult; Anxiety; Caffeine; Depression; Female; Headache; Humans; Substance Withdrawal Syndrome

1980
Caffeine withdrawal elevates urinary MHPG excretion.
    The New England journal of medicine, 1981, Feb-05, Volume: 304, Issue:6

    Topics: Caffeine; Humans; Methoxyhydroxyphenylglycol; Substance Withdrawal Syndrome

1981
24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression.
    Life sciences, 1995, Volume: 57, Issue:19

    Topics: Analysis of Variance; Animals; Brain; Caffeine; Depression; Dose-Response Relationship, Drug; Drug A

1995
Topographic quantitative EEG measures of alpha and theta power changes during caffeine withdrawal: preliminary findings from normal subjects.
    Clinical EEG (electroencephalography), 1995, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Alpha Rhythm; Brain Mapping; Caffeine; Cerebral Cortex; Electroencephalography; F

1995
Caffeine and psychomotor performance: a reply to James.
    Addiction (Abingdon, England), 1995, Volume: 90, Issue:9

    Topics: Affect; Animals; Arousal; Caffeine; Humans; Psychomotor Performance; Substance Withdrawal Syndrome

1995
Caffeine, caffeine withdrawal and psychomotor performance: a reply to James.
    Neuropsychobiology, 1995, Volume: 31, Issue:4

    Topics: Animals; Caffeine; Humans; Psychomotor Performance; Substance Withdrawal Syndrome

1995
Locomotor activity in mice during chronic treatment with caffeine and withdrawal.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Caffeine; Dopamine Agents; Dose-Response Relationsh

1993
Ethanol inhibits NMDA-receptor mediated regulation of immediate early gene expression.
    Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1993, Volume: 2

    Topics: Alcoholism; Animals; Brain; Caffeine; Dizocilpine Maleate; Ethanol; Gene Expression Regulation; Gene

1993
Caffeine withdrawal increases lithium blood levels.
    Biological psychiatry, 1995, Mar-01, Volume: 37, Issue:5

    Topics: Adult; Aged; Bipolar Disorder; Caffeine; Dose-Response Relationship, Drug; Female; Humans; Lithium;

1995
Does caffeine enhance or merely restore degraded psychomotor performance?
    Neuropsychobiology, 1994, Volume: 30, Issue:2-3

    Topics: Arousal; Attention; Caffeine; Circadian Rhythm; Coffee; Dose-Response Relationship, Drug; Humans; Ps

1994
Drinking history is related to persistent blood pressure dysregulation in postwithdrawal alcoholics.
    Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:5

    Topics: Adult; Alcoholism; Arousal; Caffeine; Ethanol; Follow-Up Studies; Humans; Hypertension; Male; Middle

1994
Barbiturate, analgesic, and caffeine withdrawal.
    The American journal of emergency medicine, 1994, Volume: 12, Issue:5

    Topics: Adult; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Barbiturates; Caffeine; Coma; Drug Comb

1994
Caffeine dependence syndrome. Evidence from case histories and experimental evaluations.
    JAMA, 1994, Oct-05, Volume: 272, Issue:13

    Topics: Adult; Caffeine; Case-Control Studies; Double-Blind Method; Female; Humans; Male; Psychiatric Status

1994
Caffeine dependence. What are the implications?
    JAMA, 1994, Oct-05, Volume: 272, Issue:13

    Topics: Caffeine; Humans; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Substance-Related

1994
Postoperative transient hemihypaesthesia and severe headache associated with caffeine withdrawal.
    Anaesthesia, 1994, Volume: 49, Issue:3

    Topics: Adult; Caffeine; Coffee; Female; Headache; Humans; Hypesthesia; Postoperative Complications; Substan

1994
Caffeine withdrawal: apparent heterologous sensitization to adenosine and prostacyclin actions in human platelets.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adolescent; Adult; Alprostadil; Blood Platelets; Caffe

1993
Caffeine withdrawal, metoclopramide, and depression.
    The American journal of gastroenterology, 1993, Volume: 88, Issue:9

    Topics: Adult; Caffeine; Depressive Disorder; Drug Interactions; Humans; Male; Metoclopramide; Substance Wit

1993
Primary caffeine dependence: a case report.
    Hawaii medical journal, 1993, Volume: 52, Issue:7

    Topics: Adult; Caffeine; Humans; Male; Substance Withdrawal Syndrome; Substance-Related Disorders

1993
Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3

    Topics: Animals; Brain; Caffeine; Dose-Response Relationship, Drug; Infusion Pumps, Implantable; Infusions,

1993
Perioperative ingestion of caffeine and postoperative headache.
    Mayo Clinic proceedings, 1993, Volume: 68, Issue:9

    Topics: Adult; Aged; Caffeine; Coffee; Female; Headache; Humans; Male; Middle Aged; Postoperative Period; Pr

1993
For want of a cup of coffee.
    Mayo Clinic proceedings, 1993, Volume: 68, Issue:9

    Topics: Caffeine; Headache; Humans; Postoperative Period; Preoperative Care; Substance Withdrawal Syndrome

1993
[The smart person will never sleep late; 'weekend headache' due to late and insufficient intake of caffeine].
    Nederlands tijdschrift voor geneeskunde, 1993, Sep-25, Volume: 137, Issue:39

    Topics: Adult; Caffeine; Female; Humans; Male; Middle Aged; Migraine Disorders; Substance Withdrawal Syndrom

1993
Overnight caffeine abstinence and negative reinforcement of preference for caffeine-containing drinks.
    Psychopharmacology, 1995, Volume: 120, Issue:4

    Topics: Adolescent; Adult; Affect; Caffeine; Conditioning, Psychological; Female; Humans; Male; Reinforcemen

1995
[Caffeine--the gentle addictive stimulant].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1995, Dec-10, Volume: 115, Issue:30

    Topics: Caffeine; Coffee; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders

1995
Mitral regurgitation caused by chronic ergotamine use.
    American heart journal, 1996, Volume: 131, Issue:3

    Topics: Adult; Caffeine; Chronic Disease; Drug Combinations; Ergotamine; Ergotism; Female; Humans; Migraine

1996
Caffeine dependence: an alternative view.
    Nature medicine, 1996, Volume: 2, Issue:5

    Topics: Affect; Caffeine; Headache; Humans; Models, Psychological; Substance Withdrawal Syndrome; Substance-

1996
Does caffeine cessation increase firing rates of diffuse paroxysmal slowing dysrhythmia? A serendipitous observation.
    Clinical EEG (electroencephalography), 1996, Volume: 27, Issue:2

    Topics: Adult; Caffeine; Cerebral Cortex; Electroencephalography; Evoked Potentials; Female; Humans; Male; S

1996
[Episodic headache, diminished performance and depressive mood].
    Praxis, 1996, May-28, Volume: 85, Issue:22

    Topics: Adult; Caffeine; Depression; Fatigue; Headache; Humans; Male; Substance Withdrawal Syndrome

1996
Influence of caffeine and caffeine withdrawal on headache and cerebral blood flow velocities.
    Cephalalgia : an international journal of headache, 1997, Volume: 17, Issue:3

    Topics: Adult; Caffeine; Cerebrovascular Circulation; Female; Headache; Humans; Male; Middle Aged; Substance

1997
Anxiogenic action of caffeine: an experimental study in rats.
    Journal of psychopharmacology (Oxford, England), 1997, Volume: 11, Issue:3

    Topics: Animals; Anxiety; Caffeine; Central Nervous System Stimulants; Drug Tolerance; Exploratory Behavior;

1997
A systematic survey of caffeine intake in Vermont.
    Experimental and clinical psychopharmacology, 1997, Volume: 5, Issue:4

    Topics: Adolescent; Adult; Age Factors; Age of Onset; Aged; Alcohol Drinking; Beverages; Caffeine; Central N

1997
Caffeine withdrawal after head and neck surgery.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:6

    Topics: Caffeine; Carcinoma, Squamous Cell; Humans; Male; Middle Aged; Pharyngeal Neoplasms; Postoperative C

1997
Nicotine and caffeine use as confounds in psychiatric studies.
    Biological psychiatry, 1997, Dec-15, Volume: 42, Issue:12

    Topics: Caffeine; Case-Control Studies; Central Nervous System Stimulants; Humans; Nicotine; Nicotinic Agoni

1997
Caffeine abstinence augments the systolic blood pressure response to adenosine in humans.
    The American journal of cardiology, 1998, Jun-01, Volume: 81, Issue:11

    Topics: Adenosine; Adult; Blood Pressure; Caffeine; Heart Rate; Humans; Male; Middle Aged; Purinergic P1 Rec

1998
Effects of caffeine withdrawal from the diet on the metabolism of clozapine in schizophrenic patients.
    Journal of clinical psychopharmacology, 1998, Volume: 18, Issue:4

    Topics: Adult; Antipsychotic Agents; Biological Availability; Biotransformation; Caffeine; Chromatography, H

1998
Caffeine withdrawal in normal school-age children.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1998, Volume: 37, Issue:8

    Topics: Analysis of Variance; Attention; Caffeine; Central Nervous System Stimulants; Child; Cognition Disor

1998
Regulation of G proteins and adenylyl cyclase in brain regions of caffeine-tolerant and -dependent mice.
    Brain research, 1998, Aug-31, Volume: 804, Issue:1

    Topics: Adenylyl Cyclases; Animals; Behavior, Animal; Brain; Caffeine; Dose-Response Relationship, Drug; Dru

1998
Endorsement of DSM-IV dependence criteria among caffeine users.
    Drug and alcohol dependence, 1998, Oct-01, Volume: 52, Issue:2

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Female; Humans; Male; Middle Aged; Psychiatric S

1998
Adenosine kinase inhibitors attenuate opiate withdrawal via adenosine receptor activation.
    European journal of pharmacology, 1998, Nov-27, Volume: 362, Issue:1

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine Kinase; Animals; Body Weight; Caffeine; De

1998
The effects of caffeine withdrawal on cognitive P300 auditory and visual evoked potentials.
    Clinical EEG (electroencephalography), 1999, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Caffeine; Event-Related Potentials, P300; Evoked Potentials, Auditory; Evoked Pot

1999
Caffeine intake, tolerance, and withdrawal in women: a population-based twin study.
    The American journal of psychiatry, 1999, Volume: 156, Issue:2

    Topics: Adult; Caffeine; Carbonated Beverages; Coffee; Diseases in Twins; Drug Overdose; Drug Tolerance; Fem

1999
Intravascular source of adenosine during forearm ischemia in humans: implications for reactive hyperemia.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 33, Issue:6

    Topics: Adenosine; Adult; Caffeine; Female; Forearm; Humans; Hyperemia; Ischemia; Male; Microdialysis; Muscl

1999
Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Dec-15, Volume: 19, Issue:24

    Topics: Adenosine; Animals; Brain; Caffeine; Cocaine; Differential Threshold; Dopamine Uptake Inhibitors; Dr

1999
Adenosine receptors are involved in the control of acute naloxone-precipitated withdrawal: in vitro evidence.
    Life sciences, 2000, Volume: 66, Issue:10

    Topics: Adenosine; Animals; Caffeine; Dipyridamole; Guinea Pigs; Ileum; In Vitro Techniques; Male; Naloxone;

2000
Reversal of caffeine withdrawal by ingestion of a soft beverage.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:1

    Topics: Adult; Beverages; Blood Glucose; Blood Pressure; Caffeine; Cerebrovascular Circulation; Female; Huma

2000
Caffeine increases paragigantocellularis neuronal firing rate and induces withdrawal signs in morphine-dependent rats.
    European journal of pharmacology, 2001, Feb-02, Volume: 412, Issue:3

    Topics: Adenosine; Analgesics, Opioid; Animals; Caffeine; Electrophysiology; Male; Medulla Oblongata; Microi

2001
Clinical features of withdrawal headache following overuse of triptans and other headache drugs.
    Neurology, 2002, May-14, Volume: 58, Issue:9

    Topics: Analgesics; Caffeine; Causality; Codeine; Drug Overdose; Headache; Headache Disorders; Humans; Prosp

2002
Consequences of interaction between opioid and receptor.
    Biochemical Society transactions, 1977, Volume: 5, Issue:1

    Topics: Analgesics, Opioid; Animals; Brain; Caffeine; Cyclic AMP; Cyclic GMP; Drug Tolerance; Humans; Ileum;

1977
Dyskinesia after discountinuation of compound analgesic containing oxycodone.
    Lancet (London, England), 1977, Apr-02, Volume: 1, Issue:8014

    Topics: Aspirin; Caffeine; Codeine; Drug Combinations; Female; Humans; Middle Aged; Movement Disorders; Oxyc

1977
Two types of insomnia: too much waking or not enough sleep.
    The British journal of psychiatry : the journal of mental science, 1975, Volume: 126

    Topics: Age Factors; Caffeine; Electroencephalography; Eye Movements; Female; Humans; Hypnotics and Sedative

1975
Morphone abstinence and quasi-abstinence effects after phosphodiesterase inhibitors and naloxone.
    Life sciences, 1975, Jun-15, Volume: 16, Issue:12

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffei

1975
Caffeine elicited withdrawal signs in morphine-dependent rhesus monkeys.
    European journal of pharmacology, 1978, Aug-01, Volume: 50, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Behavior, Animal; Benzoates; Brain; Caffeine; Conditio

1978
Mechanism of quasi-morphine withdrawal behaviour induced by methylxanthines.
    European journal of pharmacology, 1979, Feb-01, Volume: 53, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Humans;

1979
Caffeine-withdrawal headache and fasting.
    New York state journal of medicine, 1977, Volume: 77, Issue:2

    Topics: Adolescent; Adult; Caffeine; Child; Coffee; Diet; Fasting; Female; Headache; Humans; Jews; Male; Sub

1977
Evidence for withdrawal from caffeine by rats.
    Pharmacology, biochemistry, and behavior, 1977, Volume: 6, Issue:5

    Topics: Animals; Avoidance Learning; Caffeine; Humans; Male; Rats; Saccharin; Substance Withdrawal Syndrome

1977
Problems with non-prescribed agents.
    Journal of the Indian Medical Association, 1992, Volume: 90, Issue:11

    Topics: Adult; Aged; Caffeine; Humans; Male; Middle Aged; Substance Withdrawal Syndrome

1992
Caffeine tolerance and choice in humans.
    Psychopharmacology, 1992, Volume: 108, Issue:1-2

    Topics: Adult; Affect; Anxiety; Caffeine; Diet; Drug Tolerance; Female; Humans; Male; Psychiatric Status Rat

1992
Clinical importance of caffeine withdrawal.
    The New England journal of medicine, 1992, Oct-15, Volume: 327, Issue:16

    Topics: Caffeine; Humans; Substance Withdrawal Syndrome

1992
Weekend attacks in migraine patients: caused by caffeine withdrawal?
    Cephalalgia : an international journal of headache, 1992, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Caffeine; Chi-Square Distribution; Female; Humans; Male; Middle Aged; Migraine Di

1992
From the Alcohol, Drug Abuse, and Mental Health Administration.
    JAMA, 1991, Aug-28, Volume: 266, Issue:8

    Topics: Brain; Caffeine; Cocaine; Diazepam; Drug Synergism; Ethanol; Fetus; Humans; Memory; Memory Disorders

1991
An original method for assessment of the jumping test.
    Methods and findings in experimental and clinical pharmacology, 1991, Volume: 13, Issue:7

    Topics: Animals; Behavior, Animal; Caffeine; Guanfacine; Male; Methods; Mice; Mice, Inbred Strains; Morphine

1991
Caffeine and theophylline as adenosine receptor antagonists in humans.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adult; Caffeine; Heart Rate; Humans; Male; Platelet Ag

1991
Effects of caffeine on tobacco withdrawal.
    Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:2

    Topics: Adult; Caffeine; Dose-Response Relationship, Drug; Female; Headache; Humans; Hunger; Male; Patient C

1991
Does restriction of caffeine intake affect mixed function oxidase activity and caffeine metabolism?
    Biopharmaceutics & drug disposition, 1990, Volume: 11, Issue:7

    Topics: 17-Hydroxycorticosteroids; Adult; Caffeine; Coffee; Enzyme Induction; Female; gamma-Glutamyltransfer

1990
Is caffeine withdrawal the mechanism of postoperative headache?
    Anesthesia and analgesia, 1991, Volume: 72, Issue:4

    Topics: Adult; Aged; Anesthesia, General; Caffeine; Female; Headache; Humans; Male; Middle Aged; Postoperati

1991
Do-Do abuse.
    The British journal of psychiatry : the journal of mental science, 1990, Volume: 157

    Topics: Adult; Antitussive Agents; Caffeine; Drug Combinations; Ephedrine; Female; Humans; Male; Middle Aged

1990
Headache caused by caffeine withdrawal among moderate coffee drinkers switched from ordinary to decaffeinated coffee: a 12 week double blind trial.
    BMJ (Clinical research ed.), 1990, Jun-16, Volume: 300, Issue:6739

    Topics: Adult; Caffeine; Coffee; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged; Substance

1990
The anxiogenic effects of caffeine.
    Postgraduate medical journal, 1990, Volume: 66 Suppl 2

    Topics: Adult; Anxiety Disorders; Caffeine; Diet; Female; Humans; Panic; Substance Withdrawal Syndrome

1990
The effect of smoking on caffeine elimination: implications for its use as a semiquantitative test of liver function.
    Clinical and experimental pharmacology & physiology, 1988, Volume: 15, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adult; Antipyrine; Caffeine; Chromatography, High Pressure Liquid; Fema

1988
Caffeine: use and abuse.
    Nursing standard (Royal College of Nursing (Great Britain) : 1987), 1989, Jul-29, Volume: 44, Issue:3

    Topics: Caffeine; Female; Health Education; Humans; Male; Nursing Staff; Students, Nursing; Substance Withdr

1989
Does caffeine withdrawal contribute to postanaesthetic morbidity?
    Lancet (London, England), 1989, Jun-10, Volume: 1, Issue:8650

    Topics: Adolescent; Adult; Aged; Anesthesia, General; Caffeine; Female; Headache; Humans; Male; Middle Aged;

1989
Cardiovascular reactivity, mood, and task performance in deprived and nondeprived coffee drinkers.
    Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 1989, Volume: 8, Issue:4

    Topics: Adolescent; Adult; Affect; Arousal; Attention; Caffeine; Coffee; Color Perception; Discrimination Le

1989
Caffeine abstinence effects in humans.
    NIDA research monograph, 1989, Volume: 95

    Topics: Arousal; Caffeine; Fatigue; Headache; Humans; Substance Withdrawal Syndrome

1989
Longterm prognosis of analgesic withdrawal in patients with drug-induced headaches.
    Headache, 1989, Volume: 29, Issue:8

    Topics: Adult; Caffeine; Ergotamine; Female; Headache; Humans; Male; Middle Aged; Prognosis; Pyrazoles; Pyra

1989
Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex.
    The Journal of clinical investigation, 1986, Volume: 77, Issue:1

    Topics: Adenosine; Adenylyl Cyclases; Animals; Caffeine; Cerebral Cortex; Cross-Linking Reagents; Guanine Nu

1986
The caffeine withdrawal flush: report of a case of "weekend flushing".
    Military medicine, 1986, Volume: 151, Issue:2

    Topics: Adult; Caffeine; Female; Flushing; Humans; Substance Withdrawal Syndrome; Time Factors

1986
Pharmacologic specificity of tolerance to caffeine-induced stimulation of locomotor activity.
    Psychopharmacology, 1987, Volume: 93, Issue:4

    Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Male; Motor

1987
A survey of caffeine use and associated side effects in a college population.
    Journal of drug education, 1988, Volume: 18, Issue:3

    Topics: Adult; Caffeine; Data Collection; Fatigue; Female; Humans; Male; Middle Aged; Students; Substance Wi

1988
Behavioral dependence on caffeine and phencyclidine in rhesus monkeys: interactive effects.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:4

    Topics: Animals; Behavior, Animal; Caffeine; Drug Interactions; Feeding Behavior; Macaca mulatta; Male; Phen

1988
Lithium tremor and caffeine intake: two cases of drinking less and shaking more.
    The Journal of clinical psychiatry, 1988, Volume: 49, Issue:2

    Topics: Adult; Bipolar Disorder; Caffeine; Coffee; Female; Humans; Lithium; Middle Aged; Substance Withdrawa

1988
Effects of caffeine withdrawal on motor performance and heart rate changes.
    International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 1988, Volume: 6, Issue:1

    Topics: Adult; Attention; Caffeine; Female; Heart Rate; Humans; Male; Psychomotor Performance; Reaction Time

1988
Endogenous adenosine and hemorrhagic shock: effects of caffeine administration or caffeine withdrawal.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:12

    Topics: Adenosine; Animals; Blood Pressure; Caffeine; Male; Rats; Rats, Inbred Strains; Shock, Hemorrhagic;

1988
[Clouding of consciousness on the withdrawal of caffeine and sodium benzoate].
    Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 1988, Volume: 23, Issue:1

    Topics: Benzoates; Benzoic Acid; Caffeine; Cognition Disorders; Consciousness Disorders; Humans; Male; Middl

1988
Caffeine withdrawal headache.
    Journal of clinical pharmacy and therapeutics, 1987, Volume: 12, Issue:1

    Topics: Adult; Caffeine; Diet; Headache; Humans; Male; Pharmaceutical Preparations; Substance Withdrawal Syn

1987
Caffeine and the benign encephalopathy of pregnancy.
    Acta neurologica Scandinavica, 1987, Volume: 75, Issue:1

    Topics: Brain Diseases; Caffeine; Female; Humans; Pregnancy; Pregnancy Complications; Substance Withdrawal S

1987
Caffeine withdrawal symptoms.
    The American journal of emergency medicine, 1987, Volume: 5, Issue:5

    Topics: Caffeine; Humans; Substance Withdrawal Syndrome

1987
Tolerance to caffeine-induced stimulation of locomotor activity in rats.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:2

    Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Motor Activity; Rats; Rat

1986
Acute abstinence syndrome after epidural injection of butorphanol.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:4

    Topics: Adult; Anesthesia, Epidural; Aspirin; Blood Pressure; Butorphanol; Caffeine; Cesarean Section; Codei

1985
Caffeine consumption, withdrawal and cerebral blood flow.
    Headache, 1985, Volume: 25, Issue:6

    Topics: Adult; Caffeine; Cerebrovascular Circulation; Female; Humans; Male; Middle Aged; Substance Withdrawa

1985
[Drugs and traffic--drug effects on efficiency and its importance for traffic safety. II].
    Zeitschrift fur arztliche Fortbildung, 1968, Nov-15, Volume: 62, Issue:22

    Topics: Accidents, Traffic; Adult; Analgesics; Anticoagulants; Anticonvulsants; Antihypertensive Agents; Caf

1968
Anxiety or caffeinism: a diagnostic dilemma.
    The American journal of psychiatry, 1974, Volume: 131, Issue:10

    Topics: Adult; Anxiety Disorders; Cacao; Caffeine; Carbonated Beverages; Coffee; Diagnosis, Differential; Do

1974
Migraine headaches.
    JAMA, 1972, Dec-11, Volume: 222, Issue:11

    Topics: Caffeine; Contraceptives, Oral; Cyproheptadine; Diagnosis, Differential; Diuretics; Drug Combination

1972
Experimental studies on the effective procedure to inhibit the development of tolerance to and dependence on morphine.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:10

    Topics: Analgesia; Animals; Caffeine; Drug Synergism; Drug Tolerance; Haplorhini; Humans; Injections, Subcut

1970
Lack of sobering effect of fructose-vitamin tablets.
    The Medical journal of Australia, 1970, Mar-28, Volume: 1, Issue:13

    Topics: Alcohol Drinking; Caffeine; Chlorophyll; Ethanol; Fructose; Humans; Pyridoxine; Substance Withdrawal

1970