caffeine has been researched along with Sensitivity and Specificity in 182 studies
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously shown that a combination of glucosyl hesperidin (G-hesperidin) plus caffeine reduces accumulation of body fat, whereas G-hesperidin or caffeine alone shows little effect on high-fat diet-induced obesity in mice." | 9.22 | Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial. ( Murosaki, S; Muroyama, K; Ohara, T; Yamamoto, Y, 2016) |
| "The most commonly used laboratory test for predicting malignant hyperthermia susceptibility is the caffeine halothane contracture test." | 9.07 | Prediction of malignant hyperthermia susceptibility in low-risk subjects. An epidemiologic investigation of caffeine halothane contracture responses. The North American Malignant Hyperthermia Registry. ( Bunn, JS; Diaz, M; Landis, JR; Larach, MG, 1992) |
| " The center followed the diagnostic protocols of the North America MH Group, in which the contractures of biopsies from the vastus lateralis muscle are analyzed after exposure to caffeine and halothane (CHCT)." | 7.76 | Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil. ( Abreu, AV; Aguiar, MI; Cardoso, LA; Carmo, PL; Cunha, LB; Matos, AR; Sudo, RT; Trachez, MM; Zapata-Sudo, G, 2010) |
| " Clearance (Cl) was calculated using the equation of Cl = Kel x Vd (Kel = elimination rate constant, Vd = volume of distribution) and half-life was determined using pharmacokinetic analysis." | 5.31 | Caffeine clearance in patients with hepatocellular carcinoma after transcatheter oily chemoembolization treatment. ( Janchai, A; Mahachai, V; Tangkijvanich, P; Thong-Ngam, D; Thumvijit, L; Wittayalertpanya, S, 2002) |
| "We have previously shown that a combination of glucosyl hesperidin (G-hesperidin) plus caffeine reduces accumulation of body fat, whereas G-hesperidin or caffeine alone shows little effect on high-fat diet-induced obesity in mice." | 5.22 | Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial. ( Murosaki, S; Muroyama, K; Ohara, T; Yamamoto, Y, 2016) |
| "This multicenter, randomized, double-blind, placebo-controlled, parallel-group study includes patients with suspected coronary artery disease who regularly consume caffeine." | 5.15 | Effect of caffeine on SPECT myocardial perfusion imaging during regadenoson pharmacologic stress: rationale and design of a prospective, randomized, multicenter study. ( Franks, B; Iskandrian, AE; McNutt, BE; Tejani, FH; Thompson, RC, 2011) |
| "The purpose of this study was to evaluate caffeine clearance, a quantitative measurement of metabolizing capacity of the liver, in chronic hepatitis B and C before and after interferon treatment." | 5.09 | Caffeine clearance in patients with chronic viral hepatitis: before and after interferon therapy. ( Mahachai, V; Wittayalertpanya, S, 2001) |
| "The most commonly used laboratory test for predicting malignant hyperthermia susceptibility is the caffeine halothane contracture test." | 5.07 | Prediction of malignant hyperthermia susceptibility in low-risk subjects. An epidemiologic investigation of caffeine halothane contracture responses. The North American Malignant Hyperthermia Registry. ( Bunn, JS; Diaz, M; Landis, JR; Larach, MG, 1992) |
| " Extreme PB was identified in 76 infants and in 45% was temporally associated with clinical events including infection or necrotizing enterocolitis (NEC), immunizations, or caffeine discontinuation." | 3.83 | Clinical associations with immature breathing in preterm infants: part 2-periodic breathing. ( Delos, J; Fairchild, K; Kattwinkel, J; Lake, D; Mohr, M; Moorman, JR; Patel, M; Sinkin, RA, 2016) |
| " The center followed the diagnostic protocols of the North America MH Group, in which the contractures of biopsies from the vastus lateralis muscle are analyzed after exposure to caffeine and halothane (CHCT)." | 3.76 | Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil. ( Abreu, AV; Aguiar, MI; Cardoso, LA; Carmo, PL; Cunha, LB; Matos, AR; Sudo, RT; Trachez, MM; Zapata-Sudo, G, 2010) |
| "We have examined the modulation of radiosensitivity by using caffeine in two human sarcoma cell lines both with a p53 mutation (US8-93 and LMS6-93)." | 3.71 | Loss of G2/M arrest correlates with radiosensitization in two human sarcoma cell lines with mutant p53. ( Bache, M; Bartel, F; Dunst, J; Meye, A; Pigorsch, S; Rath, FW; Schmidt, H; Taubert, H; Würl, P, 2001) |
| "Caffeine has been extensively used as a probe to measure CYP1A2 activity in humans with caffeine clearance or the paraxanthine (major metabolite of caffeine) to caffeine concentration ratio being regarded as the preferred metric." | 2.75 | Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma. ( Gross, AS; McLachlan, AJ; Perera, V, 2010) |
| " To evaluate the sensitivity of the Finometer in recording longer-term effects of a daily dosage of 1000 mg vitamin C, 800 mg vitamin E and 10 mg folic acid, 14 young males took placebo and 17 took the vitamins for 12 weeks in a double-blind study." | 2.71 | Sensitivity of the Finometer device in detecting acute and medium-term changes in cardiovascular function. ( Huisman, HW; Jerling, JC; Oosthuizen, W; Schutte, AE; Van Rooyen, JM, 2003) |
| "Caffeine is a non-selective antagonist at the adenosine receptors, which is expected to reverse both the intended (coronary vasodilation) and unintended (hypotension, flushing) effects of exogenously administered adenosine and adenosine-related compounds." | 1.43 | Caffeine reduces the sensitivity of vasodilator MPI for the detection of myocardial ischaemia: Pro. ( Reyes, E, 2016) |
| " Here, a 3-h caffeine/colcemid co-treatment before harvesting at 55 h post-exposure is used so that the dicentric analysis using Giemsa staining is based predominantly on lymphocytes released from the G2-block, increasing thus dicentric yield and enabling construction of a dose-response calibration curve with improved precision of high-dose estimates." | 1.43 | Biodosimetry for High-Dose Exposures Based on Dicentric Analysis in Lymphocytes Released from the G2-Block by Caffeine. ( Dimitriou, P; Hatzi, V; Karachristou, I; Karaiskos, P; Karakosta, M; Pantelias, A; Pantelias, G; Terzoudi, GI; Thanassoulas, A, 2016) |
| "Caffeine has attracted abundant attention due to its extensive existence in beverages and medicines." | 1.39 | Make caffeine visible: a fluorescent caffeine "traffic light" detector. ( Agrawalla, BK; Chang, YT; Cho, YK; Er, JC; Kale, AA; Kim, TH; Xu, W; Zhai, D; Zhang, L, 2013) |
| " This method can be applied to the pharmacokinetic study of norfloxacin and enoxacin after repeated administration to assess changes in CYP1A2 activity in healthy subjects." | 1.37 | A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition. ( Homma, M; Kobayashi, D; Kobayashi, T; Kohda, Y; Momo, K, 2011) |
| "Genotyping N-acetyltransferase 2 (NAT2) is of high relevance for individualized dosing of antituberculosis drugs and bladder cancer epidemiology." | 1.37 | Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype. ( Albers, P; Angeli-Greaves, M; Aslam, M; Bánfi, G; Barski, D; Blaszkewicz, M; Bolt, HM; Brenner, W; Dietrich, H; Ebbinghaus, R; Ekici, AB; Falkenstein, M; Frees, S; Gerullis, H; Golka, K; Guballa, C; Hassan Rizvi, SA; Hengstler, JG; Ickstadt, K; Klein, T; Kress, A; Lehmann, ML; Löhlein, D; Moormann, O; Niegisch, G; Otto, T; Ovsiannikov, D; Prager, HM; Reckwitz, T; Roemer, HC; Romics, I; Roth, G; Schöps, W; Schwender, H; Seidel, T; Selinski, S; Steffens, M; Thüroff, JW; Truss, MC; Weistenhöfer, W; Winterpacht, A; Zimmermann, A, 2011) |
| "The theanine in the tea was extracted with water." | 1.36 | [Theanine, EGCG and caffeine determinated by HPLC]. ( Cui, X; Diao, F; Dong, F; Guo, D; Liu, N; Wang, Q, 2010) |
| " The application of the assay to determine the pharmacokinetic disposition after a single oral dose to rats is described." | 1.34 | Stereospecific determination of cis- and trans-resveratrol in rat plasma by HPLC: application to pharmacokinetic studies. ( Chen, X; He, H; Ma, L; Ren, W; Wang, G; Yang, B; Yu, Q, 2007) |
| "Caffeine was determined in ground and instant coffee with precision and accuracy that meet Brazilian norms about such products." | 1.34 | Determination of caffeine in coffee products by dynamic complexation with 3,4-dimethoxycinnamate and separation by CZE. ( do Lago, CL; Nogueira, T, 2007) |
| " The results of the proposed method were in excellent agreement with those obtained from PLS and HPLC methods and can be satisfactorily used for routine analysis of multicomponent dosage forms." | 1.33 | Content uniformity and dissolution tests of triplicate mixtures by a double divisor-ratio spectra derivative method. ( Koundourellis, JE; Malliou, ET; Markopoulou, CK, 2005) |
| "Oxyphenbutazone in the sample was found to be present at a level below the quantification level of 10." | 1.32 | Analysis of adulterants in a traditional herbal medicinal product using liquid chromatography-mass spectrometry-mass spectrometry. ( Holmes, MJ; Koh, HL; Lau, AJ; Woo, SO, 2003) |
| " Clearance (Cl) was calculated using the equation of Cl = Kel x Vd (Kel = elimination rate constant, Vd = volume of distribution) and half-life was determined using pharmacokinetic analysis." | 1.31 | Caffeine clearance in patients with hepatocellular carcinoma after transcatheter oily chemoembolization treatment. ( Janchai, A; Mahachai, V; Tangkijvanich, P; Thong-Ngam, D; Thumvijit, L; Wittayalertpanya, S, 2002) |
| "Smoking during pregnancy is a significant public health issue, and studies of the effectiveness of interventions to reduce maternal smoking require accurate measurement of smoking status." | 1.31 | A simple high-pressure liquid chromatography cotinine assay: validation of smoking status in pregnant women. ( Brennecke, S; Greaves, R; Janus, E; Trotter, L, 2001) |
| "Caffeine was also very frequently present in river and ground water, although its presence in lake water was rare." | 1.31 | Use of an automated on-line SPE-HPLC method to monitor caffeine and selected aniline and phenol compounds in aquatic systems of Macedonia-Thrace, Greece. ( Koukourikou, A; Papadakis, E; Papadopoulou-Mourkidou, E; Patsias, J, 2001) |
| " MHEh muscles revealed a dose-response curve similar to that found in MHN specimens." | 1.30 | Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol. ( Bittner, RE; Fricker, R; Gilly, H; Kress, HG; Musat, I; Steinbereithner, K, 1997) |
| " The type of fibres (type I: oxidative, slow; type II: glycolytic, fast) were determined with strontium dose-response curves." | 1.30 | [Caffeine skinned fiber tension test: application to the diagnosis of susceptibility to malignant hyperthermia]. ( Adnet, P; Börtlein, ML; Etchrivi, T; Haudecoeur, G; Krivosic-Horber, R; Nivoche, Y; Tavernier, B, 1999) |
| "A rapid simple and robust reversed-phase HPLC method was developed for rapid screening in bioavailability studies or comparative bioequivalence studies." | 1.29 | Rapid high-performance liquid chromatographic determination of vancomycin in human plasma. ( Luksa, J; Marusic, A, 1995) |
| "30 hours, and bioavailability of 99." | 1.29 | Application of an enzyme-multiplied immunoassay technique for determination of caffeine elimination kinetics as a test of liver function in clinically normal dogs. ( DeGraves, FJ; Golden, DL; Spano, JS; Whatley, EM; Wilson, RC, 1994) |
| " Cumulative dose-response curves for chlordiazepoxide were obtained before and during chronic chlordiazepoxide administration and during chronic saline administration." | 1.29 | Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity. ( Alastra, AJ; Cohen, C; Goldberg, SR; Marley, RJ; Sannerud, CA; Serdikoff, SL, 1993) |
| "Caffeine sensitivity was defined as the threshold concentration inducing > 10% of the maximal tension obtained after the fiber was loaded with a 1." | 1.29 | In vitro human masseter muscle hypersensitivity: a possible explanation for increase in masseter tone. ( Adnet, PJ; Etchrivi, T; Haudecoeur, G; Krivosic, I; Krivosic-Horber, R; Reyford, H; Tavernier, BM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 45 (24.73) | 18.2507 |
| 2000's | 85 (46.70) | 29.6817 |
| 2010's | 46 (25.27) | 24.3611 |
| 2020's | 6 (3.30) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Li, H | 1 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 1 |
| Yan, Z | 1 |
| Liu, X | 1 |
| Sun, Y | 1 |
| He, Z | 1 |
| Sebaiy, MM | 1 |
| El-Adl, SM | 1 |
| Mattar, AA | 1 |
| Mendes, VM | 1 |
| Coelho, M | 1 |
| Tomé, AR | 1 |
| Cunha, RA | 1 |
| Manadas, B | 1 |
| van Assen, M | 1 |
| Kuijpers, DJ | 1 |
| Schwitter, J | 1 |
| Ahmad, R | 1 |
| Ahmad, N | 1 |
| Al-Anaki, WS | 1 |
| Ismail, FA | 1 |
| Al-Jishi, F | 1 |
| Eagles, SK | 1 |
| Wang, X | 1 |
| Gross, AS | 2 |
| McLachlan, AJ | 2 |
| Zhang, YS | 2 |
| Lee, HE | 1 |
| Kwan, CC | 1 |
| Schwartz, GW | 1 |
| Fawzi, AA | 1 |
| Ibrahim, H | 1 |
| Hamdy, AM | 1 |
| Merey, HA | 1 |
| Saad, AS | 1 |
| De Luca, S | 1 |
| Ciotoli, E | 1 |
| Biancolillo, A | 1 |
| Bucci, R | 1 |
| Magrì, AD | 1 |
| Marini, F | 1 |
| Williams, TM | 1 |
| Nyati, S | 1 |
| Ross, BD | 1 |
| Rehemtulla, A | 1 |
| Hadad, GM | 1 |
| Abdel Salam, RA | 1 |
| Soliman, RM | 1 |
| Mesbah, MK | 1 |
| Talio, MC | 1 |
| Alesso, M | 1 |
| Acosta, M | 1 |
| Acosta, MG | 1 |
| Luconi, MO | 1 |
| Fernández, LP | 1 |
| Xu, W | 1 |
| Kim, TH | 1 |
| Zhai, D | 1 |
| Er, JC | 1 |
| Zhang, L | 2 |
| Kale, AA | 1 |
| Agrawalla, BK | 1 |
| Cho, YK | 1 |
| Chang, YT | 1 |
| Peris-Vicente, J | 1 |
| Rambla-Alegre, M | 1 |
| Durgavanshi, A | 1 |
| Bose, D | 1 |
| Esteve-Romero, J | 2 |
| Marco-Peiró, S | 1 |
| Manthorpe, DP | 1 |
| Lockley, WJ | 1 |
| Lboutounne, Y | 1 |
| Silva, J | 1 |
| Pazart, L | 1 |
| Bérard, M | 1 |
| Muret, P | 1 |
| Humbert, P | 1 |
| Carlsson, M | 1 |
| Jögi, J | 1 |
| Markenroth Bloch, K | 1 |
| Hedén, B | 1 |
| Ekelund, U | 1 |
| Ståhlberg, F | 1 |
| Arheden, H | 1 |
| Rezaei, B | 1 |
| Khalili Boroujeni, M | 1 |
| Ensafi, AA | 1 |
| Mohanty, SK | 1 |
| Yu, CL | 1 |
| Gopishetty, S | 1 |
| Subramanian, M | 1 |
| Alur, P | 1 |
| Bollampalli, V | 1 |
| Bell, T | 1 |
| Hussain, N | 1 |
| Liss, J | 1 |
| Mutsaerts, HJ | 1 |
| Steketee, RM | 1 |
| Heijtel, DF | 1 |
| Kuijer, JP | 1 |
| van Osch, MJ | 1 |
| Majoie, CB | 1 |
| Smits, M | 1 |
| Nederveen, AJ | 1 |
| Ghosn, R | 1 |
| Yahia-Cherif, L | 1 |
| Hugueville, L | 1 |
| Ducorps, A | 1 |
| Lemaréchal, JD | 1 |
| Thuróczy, G | 1 |
| de Seze, R | 1 |
| Selmaoui, B | 1 |
| Jordan, NY | 1 |
| Mimpen, JY | 1 |
| van den Bogaard, WJ | 1 |
| Flesch, FM | 1 |
| van de Meent, MH | 1 |
| Torano, JS | 1 |
| De Kesel, PM | 1 |
| Lambert, WE | 1 |
| Stove, CP | 1 |
| Saito-Shida, S | 1 |
| Nemoto, S | 1 |
| Teshima, R | 1 |
| Ohara, T | 1 |
| Muroyama, K | 1 |
| Yamamoto, Y | 1 |
| Murosaki, S | 1 |
| Reyes, E | 2 |
| Patel, M | 1 |
| Mohr, M | 1 |
| Lake, D | 1 |
| Delos, J | 1 |
| Moorman, JR | 1 |
| Sinkin, RA | 1 |
| Kattwinkel, J | 1 |
| Fairchild, K | 1 |
| Karachristou, I | 1 |
| Karakosta, M | 1 |
| Pantelias, A | 1 |
| Hatzi, V | 1 |
| Pantelias, G | 1 |
| Thanassoulas, A | 1 |
| Karaiskos, P | 1 |
| Dimitriou, P | 1 |
| Terzoudi, GI | 1 |
| Dhodapkar, R | 1 |
| Kumar, A | 1 |
| Bessems, JGM | 1 |
| Paini, A | 1 |
| Gajewska, M | 1 |
| Worth, A | 1 |
| Niedorf, F | 1 |
| Schmidt, E | 1 |
| Kietzmann, M | 1 |
| Katsu, T | 1 |
| Tsunamoto, Y | 1 |
| Hanioka, N | 1 |
| Komagoe, K | 1 |
| Masuda, K | 1 |
| Narimatsu, S | 1 |
| Ogawa, A | 1 |
| Maeda, M | 1 |
| Filimonova, AA | 1 |
| Ziganshina, LE | 1 |
| Chichirov, AA | 1 |
| Ganio, MS | 1 |
| Klau, JF | 1 |
| Casa, DJ | 2 |
| Armstrong, LE | 2 |
| Maresh, CM | 2 |
| Klimacka-Nawrot, E | 1 |
| Suchecka, W | 1 |
| Xie, S | 1 |
| Walton, SP | 1 |
| Thabano, JR | 1 |
| Breadmore, MC | 1 |
| Hutchinson, JP | 1 |
| Johns, C | 1 |
| Haddad, PR | 1 |
| Nováková, L | 1 |
| Spácil, Z | 1 |
| Seifrtová, M | 1 |
| Opletal, L | 1 |
| Solich, P | 2 |
| Carvalho, JJ | 1 |
| Weller, MG | 1 |
| Panne, U | 1 |
| Schneider, RJ | 2 |
| Diao, F | 1 |
| Dong, F | 1 |
| Wang, Q | 1 |
| Liu, N | 1 |
| Guo, D | 1 |
| Cui, X | 1 |
| Choong, CL | 1 |
| Milne, WI | 1 |
| Chen, ML | 1 |
| Zheng, MM | 1 |
| Feng, YQ | 1 |
| Banko, LT | 1 |
| Haq, SA | 1 |
| Rainaldi, DA | 1 |
| Klem, I | 1 |
| Siegler, J | 1 |
| Fogel, J | 1 |
| Sacchi, TJ | 1 |
| Heitner, JF | 1 |
| Sudo, RT | 1 |
| Cunha, LB | 1 |
| Carmo, PL | 1 |
| Matos, AR | 1 |
| Trachez, MM | 1 |
| Cardoso, LA | 1 |
| Aguiar, MI | 1 |
| Abreu, AV | 1 |
| Zapata-Sudo, G | 1 |
| Panchal, JG | 1 |
| Patel, RV | 1 |
| Menon, SK | 1 |
| Kobayashi, T | 1 |
| Homma, M | 1 |
| Momo, K | 1 |
| Kobayashi, D | 1 |
| Kohda, Y | 1 |
| Fujima, N | 1 |
| Kudo, K | 1 |
| Terae, S | 1 |
| Ishizaka, K | 1 |
| Yazu, R | 1 |
| Zaitsu, Y | 1 |
| Tha, KK | 1 |
| Yoshida, D | 1 |
| Tsukahara, A | 1 |
| Haacke, ME | 1 |
| Sasaki, M | 1 |
| Shirato, H | 1 |
| Perera, V | 1 |
| Tejani, FH | 1 |
| Thompson, RC | 1 |
| Iskandrian, AE | 1 |
| McNutt, BE | 1 |
| Franks, B | 1 |
| Serra, A | 1 |
| Macià, A | 1 |
| Romero, MP | 1 |
| Piñol, C | 1 |
| Motilva, MJ | 1 |
| Selinski, S | 1 |
| Blaszkewicz, M | 1 |
| Lehmann, ML | 1 |
| Ovsiannikov, D | 1 |
| Moormann, O | 1 |
| Guballa, C | 1 |
| Kress, A | 1 |
| Truss, MC | 1 |
| Gerullis, H | 1 |
| Otto, T | 1 |
| Barski, D | 1 |
| Niegisch, G | 1 |
| Albers, P | 1 |
| Frees, S | 1 |
| Brenner, W | 1 |
| Thüroff, JW | 1 |
| Angeli-Greaves, M | 1 |
| Seidel, T | 1 |
| Roth, G | 1 |
| Dietrich, H | 1 |
| Ebbinghaus, R | 1 |
| Prager, HM | 1 |
| Bolt, HM | 1 |
| Falkenstein, M | 1 |
| Zimmermann, A | 1 |
| Klein, T | 1 |
| Reckwitz, T | 1 |
| Roemer, HC | 1 |
| Löhlein, D | 1 |
| Weistenhöfer, W | 1 |
| Schöps, W | 1 |
| Hassan Rizvi, SA | 1 |
| Aslam, M | 1 |
| Bánfi, G | 1 |
| Romics, I | 1 |
| Steffens, M | 1 |
| Ekici, AB | 1 |
| Winterpacht, A | 1 |
| Ickstadt, K | 1 |
| Schwender, H | 1 |
| Hengstler, JG | 1 |
| Golka, K | 1 |
| Kujawinski, DM | 1 |
| Jochmann, MA | 1 |
| Schmidt, TC | 1 |
| Pinhancos, R | 1 |
| Maass, S | 1 |
| Ramanathan, DM | 1 |
| Lee, JC | 1 |
| Fraser, JF | 1 |
| Barnett, AG | 1 |
| Johnson, LP | 1 |
| Wilson, MG | 1 |
| McHenry, CM | 1 |
| Walters, DL | 1 |
| Warnholtz, CR | 1 |
| Khafagi, FA | 1 |
| Liu, Y | 1 |
| Li, X | 1 |
| Yang, C | 1 |
| Tai, S | 1 |
| Zhang, X | 1 |
| Liu, G | 1 |
| Mahapatra, AK | 1 |
| Roy, J | 1 |
| Sahoo, P | 1 |
| Mukhopadhyay, SK | 1 |
| Mukhopadhyay, AR | 1 |
| Mandal, D | 1 |
| Lopez-Avila, V | 1 |
| Cooley, J | 1 |
| Urdahl, R | 1 |
| Thevis, M | 1 |
| Grandke, J | 1 |
| Oberleitner, L | 1 |
| Resch-Genger, U | 1 |
| Garbe, LA | 1 |
| Izu, LT | 1 |
| McCulle, SL | 1 |
| Ferreri-Jacobia, MT | 1 |
| Devor, DC | 1 |
| Duffey, ME | 1 |
| Zheng, XM | 1 |
| Williams, RC | 1 |
| Islander, G | 3 |
| Ording, H | 4 |
| Bendixen, D | 3 |
| Ranklev Twetman, E | 2 |
| Sekella, PT | 1 |
| Rueda, D | 1 |
| Walter, NG | 1 |
| Doherty, M | 1 |
| Smith, PM | 1 |
| Davison, RC | 1 |
| Hughes, MG | 1 |
| Chen, Z | 1 |
| Pavelic, P | 1 |
| Dillon, P | 1 |
| Naidu, R | 1 |
| Reeves, RR | 1 |
| Struve, FA | 1 |
| Patrick, G | 1 |
| Gardinali, PR | 1 |
| Zhao, X | 1 |
| Conney, AH | 1 |
| Lu, YP | 1 |
| Lou, YR | 1 |
| Huang, MT | 1 |
| Lau, AJ | 1 |
| Holmes, MJ | 1 |
| Woo, SO | 1 |
| Koh, HL | 1 |
| Thong-Ngam, D | 2 |
| Thumvijit, L | 1 |
| Tangkijvanich, P | 2 |
| Janchai, A | 1 |
| Mahachai, V | 3 |
| Wittayalertpanya, S | 3 |
| Schneider, H | 1 |
| Ma, L | 2 |
| Glatt, H | 1 |
| Wappler, F | 2 |
| Anetseder, M | 1 |
| Baur, CP | 1 |
| Censier, K | 1 |
| Doetsch, S | 1 |
| Felleiter, P | 1 |
| Fiege, M | 1 |
| Fricker, R | 2 |
| Halsall, PJ | 2 |
| Hartung, E | 2 |
| Heffron, JJ | 2 |
| Heytens, L | 2 |
| Hopkins, PM | 1 |
| Klingler, W | 1 |
| Lehmann-Horn, F | 2 |
| Nivoche, Y | 3 |
| Tegazzin, V | 2 |
| Tzanova, I | 1 |
| Urwyler, A | 2 |
| Weisshorn, R | 1 |
| Schulte am Esch, J | 1 |
| Zhang, LQ | 1 |
| Wu, XH | 1 |
| Tang, X | 1 |
| Zhu, XL | 1 |
| Su, WT | 1 |
| Zhang, J | 1 |
| Zhang, XS | 1 |
| Huang, XR | 1 |
| Fu, CM | 1 |
| Liu, WN | 1 |
| Zhang, ZH | 1 |
| Song, WS | 1 |
| Huang, J | 1 |
| Wang, SX | 1 |
| Sawyer, M | 1 |
| Kumar, V | 1 |
| Schutte, AE | 1 |
| Huisman, HW | 1 |
| Van Rooyen, JM | 1 |
| Oosthuizen, W | 1 |
| Jerling, JC | 1 |
| Taylor, ES | 1 |
| Smith, AD | 1 |
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| Herbison, GP | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Weight Management Program on Body Weight in Individuals Who Are Overweight and Otherwise Healthy[NCT04107155] | 54 participants (Actual) | Interventional | 2019-07-23 | Completed | |||
| A Randomized Controlled Trial to Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain in Overweight But Generally Healthy Adults Over the Winter Holiday Period[NCT03372109] | 23 participants (Actual) | Interventional | 2017-11-14 | Completed | |||
| Does Combined Caffeine and Carbohydrate Ingestion Counter the Exercise-mediated Fall in Glycaemia in Individuals With Type 1 Diabetes on Insulin Degludec? The DE-CAF Study[NCT04671043] | 21 participants (Actual) | Interventional | 2022-02-04 | Completed | |||
| Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia[NCT05295784] | Phase 1 | 18 participants (Anticipated) | Interventional | 2024-06-30 | Not yet recruiting | ||
| A Phase 3b, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of Caffeine Intake on Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI) in Subjects Administered Regadenoson[NCT00826280] | Phase 3 | 347 participants (Actual) | Interventional | 2009-03-24 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Baseline is the last non-missing measurement on or before first dose of regadenoson.~Change is calculated as the time point minus baseline." (NCT00826280)
Timeframe: Baseline, Day 5 (-3 min), Day 5 (+3 min), Day 5 (+15 min)
| Intervention | mmHg (Median) | |||
|---|---|---|---|---|
| Baseline [N= 113; 116;116] | Change at Day 5 (- 3 min) [N=67; 70; 71] | Change at Day 5 (+ 3 min) [N=67; 70; 72] | Change at Day 5 (+15 min) [N=66; 72; 72] | |
| Caffeine 200 mg Plus Regadenoson | 74.0 | 4.0 | 4.0 | 3.0 |
| Caffeine 400 mg Plus Regadenoson | 73.0 | 6.0 | 3.0 | 4.0 |
| Placebo Plus Regadenoson | 78.0 | 0.0 | -1.0 | -2.0 |
"Baseline is the last non-missing measurement on or before first dose of regadenoson~Change is calculated as the time point minus baseline." (NCT00826280)
Timeframe: Baseline, Day 5 (-3 min), Day 5 (+3 min), Day 5 (+15 min)
| Intervention | Beats per minute (Median) | |||
|---|---|---|---|---|
| Baseline [N=113; 116; 116] | Change at Day 5 (- 3 min) [N=67; 70; 71] | Change at Day 5 (+3 min) [N=67; 70; 72] | Change at Day 5 (+15 min) [N=66; 72; 72] | |
| Caffeine 200 mg Plus Regadenoson | 62.0 | -1.0 | 5.0 | 1.0 |
| Caffeine 400 mg Plus Regadenoson | 64.0 | -2.0 | 0.0 | -1.0 |
| Placebo Plus Regadenoson | 66.0 | -2.0 | 9.0 | 4.0 |
"Baseline is the last non-missing measurement on or before first dose of regadenoson.~Change is calculated as the time point minus baseline." (NCT00826280)
Timeframe: Baseline, Day 5 (-3 min), Day 5 (+3 min), Day 5 (+15 min)
| Intervention | mmHg (Median) | |||
|---|---|---|---|---|
| Baseline [N=113; 116; 116] | Change at Day 5 (- 3 min) [N=67;70;71] | Change at Day 5 (+3 min) [N=67; 70; 72] | Change at Day 5 (+15 min) [N=66; 72; 72] | |
| Caffeine 200 mg Plus Regadenoson | 131.0 | 12.0 | 8.0 | 8.0 |
| Caffeine 400 mg Plus Regadenoson | 135.0 | 11.0 | 7.5 | 5.0 |
| Placebo Plus Regadenoson | 135.0 | 0.0 | 0.0 | -2.0 |
"Each segment of the 17-Segment Model was assessed for radiotracer uptake on a scale of 0 (normal uptake) to 4 (absent uptake). Segments were counted as having a reversible defect if the stress score was greater than the rest score and the stress score was ≥ 2.~Change was calculated as the number of reversible defects using regadenoson with caffeine/placebo (Day 5) minus the number of reversible defects using regadenoson alone (Day 3)." (NCT00826280)
Timeframe: Day 3 and Day 5
| Intervention | Reversible Defects (Mean) | ||
|---|---|---|---|
| Baseline Stress Scan (Day 3) | Double-Blind Stress Scan (Day 5) | DoubleBlind - Baseline (Day 5 - Day 3) | |
| Caffeine 200 mg Plus Regadenoson | 1.01 | 0.40 | -0.61 |
| Caffeine 400 mg Plus Regadenoson | 1.00 | 0.38 | -0.62 |
| Placebo Plus Regadenoson | 0.67 | 0.80 | 0.12 |
"Each segment of the 17-Segment Model was assessed for radiotracer uptake on a scale of 0 (normal uptake) to 4 (absent uptake). Segments were counted as having a reversible defect if the stress score was greater than the rest score and the stress score was ≥ 2.~Change was calculated as the number of reversible defects using regadenoson with caffeine/placebo (Day 5) minus the number of reversible defects using regadenoson alone (Day 3)." (NCT00826280)
Timeframe: Day 3 and Day 5
| Intervention | Reversible Defects (Mean) | ||
|---|---|---|---|
| Baseline Stress Scan (Day 3) [N=64; 69; 70] | Double-Blind Stress Scan (Day 5) [N=66; 70; 71] | DoubleBlind - Baseline (Day 5-Day 3)[N=64; 69; 70] | |
| Caffeine 200 mg Plus Regadenoson | 2.00 | 1.46 | -0.59 |
| Caffeine 400 mg Plus Regadenoson | 2.19 | 1.42 | -0.81 |
| Placebo Plus Regadenoson | 1.47 | 1.74 | 0.31 |
"The Summed Difference Score was calculated as the difference in the Summed Stress Score across the 17 segments (scan run under stress condition) minus the Summed Rest Score across the 17 segments (scan run under rest conditions).~Change in SDS was calculated as the SDS for regadenoson with caffeine/placebo stress scan (Day 5) minus the SDS for regadenoson only stress scan (Day 3).~The full range of the SDS is -68 to 68, where 0 represents no change between Summed Stress Score and Summed Rest Score. A higher positive score indicates more severe coronary artery disease (CAD)." (NCT00826280)
Timeframe: Day 3 and Day 5
| Intervention | Sum Difference Score (Mean) | ||
|---|---|---|---|
| Baseline Stress Scan (Day 3) | Double-Blind Stress Scan (Day 5) | DoubleBlind - Baseline (Day 5 - Day 3) | |
| Caffeine 200 mg Plus Regadenoson | 2.45 | 1.42 | -1.03 |
| Caffeine 400 mg Plus Regadenoson | 2.53 | 1.27 | -1.25 |
| Placebo Plus Regadenoson | 2.24 | 2.36 | 0.11 |
"The Summed Difference Score was calculated as the difference in the Summed Stress Score across the 17 segments (scan run under stress condition) minus the Summed Rest Score across the 17 segments (scan run under rest conditions).~Change in SDS was calculated as the SDS for regadenoson with caffeine/placebo stress scan (Day 5) minus the SDS for regadenoson only stress scan (Day 3).~The full range of the SDS is -68 to 68, where 0 represents no change between Summed Stress Score and Summed Rest Score. A higher positive score indicates more severe coronary artery disease (CAD)." (NCT00826280)
Timeframe: Day 3 and Day 5
| Intervention | Summed Difference Score (Mean) | ||
|---|---|---|---|
| Baseline Stress Scan (Day 3) [N=64; 69; 70] | Double-Blind Stress Scan (Day 5) [N=66; 70; 71] | DoubleBlind - Baseline (Day 5-Day 3)[N=64; 69; 70] | |
| Caffeine 200 mg Plus Regadenoson | 4.46 | 3.10 | -1.45 |
| Caffeine 400 mg Plus Regadenoson | 4.29 | 2.46 | -1.84 |
| Placebo Plus Regadenoson | 3.34 | 4.41 | 1.02 |
5 reviews available for caffeine and Sensitivity and Specificity
| Article | Year |
|---|---|
MRI perfusion in patients with stable chest-pain.
Topics: Artifacts; Caffeine; Central Nervous System Stimulants; Chest Pain; Coronary Angiography; Coronary A | 2020 |
Effect of caffeine on sport-specific endurance performance: a systematic review.
Topics: Athletic Performance; Caffeine; Central Nervous System Stimulants; Female; Humans; Male; Muscle, Ske | 2009 |
[Methods of taste sensitivity examination].
Topics: Caffeine; Citric Acid; Electrodiagnosis; Humans; Sensitivity and Specificity; Sodium Chloride; Sodiu | 2008 |
Caffeine use in sports: considerations for the athlete.
Topics: Athletic Performance; Caffeine; Central Nervous System; Evidence-Based Medicine; Female; Humans; Mal | 2008 |
[Simultaneous determination of theophylline and its metabolites by HPLC].
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Sensitivity and Specificity; Theophylline; X | 2000 |
21 trials available for caffeine and Sensitivity and Specificity
| Article | Year |
|---|---|
Submaximal adenosine-induced coronary hyperaemia with 12 h caffeine abstinence: implications for clinical adenosine perfusion imaging tests.
Topics: Adenosine; Adult; Blood Flow Velocity; Caffeine; Coronary Circulation; Drug Administration Schedule; | 2015 |
Reproducibility of pharmacological ASL using sequences from different vendors: implications for multicenter drug studies.
Topics: Brain; Caffeine; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Drug Evaluation; Equ | 2015 |
Radiofrequency signal affects alpha band in resting electroencephalogram.
Topics: Adult; Alpha Rhythm; Caffeine; Cell Phone; Electroencephalography; Female; Humans; Hydrocortisone; M | 2015 |
Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial.
Topics: Abdominal Fat; Adiposity; Adult; Aged; Anti-Obesity Agents; Body Mass Index; Caffeine; Dose-Response | 2016 |
Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial.
Topics: Abdominal Fat; Adiposity; Adult; Aged; Anti-Obesity Agents; Body Mass Index; Caffeine; Dose-Response | 2016 |
Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial.
Topics: Abdominal Fat; Adiposity; Adult; Aged; Anti-Obesity Agents; Body Mass Index; Caffeine; Dose-Response | 2016 |
Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial.
Topics: Abdominal Fat; Adiposity; Adult; Aged; Anti-Obesity Agents; Body Mass Index; Caffeine; Dose-Response | 2016 |
Incidence of caffeine in serum of patients undergoing dipyridamole myocardial perfusion stress test by an intensive versus routine caffeine history screening.
Topics: Aged; Caffeine; Coronary Disease; Dipyridamole; Drug Interactions; Exercise Test; Female; Hemodynami | 2010 |
Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma.
Topics: Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Drug Stab | 2010 |
Effect of caffeine on SPECT myocardial perfusion imaging during regadenoson pharmacologic stress: rationale and design of a prospective, randomized, multicenter study.
Topics: Adenosine A2 Receptor Antagonists; Administration, Oral; Adult; Aged; Aged, 80 and over; Caffeine; C | 2011 |
Effect of caffeine on adenosine-induced reversible perfusion defects assessed by automated analysis.
Topics: Adenosine; Blood Flow Velocity; Caffeine; Coronary Artery Disease; Coronary Circulation; Drug Intera | 2012 |
Serum caffeine levels after 24-hour abstention: clinical implications on dipyridamole (201)Tl myocardial perfusion imaging.
Topics: Aged; Blood Pressure; Caffeine; Central Nervous System Stimulants; Dipyridamole; Exercise Test; Fals | 2002 |
Caffeine is ergogenic after supplementation of oral creatine monohydrate.
Topics: Adult; Anaerobic Threshold; Analysis of Variance; Blood Chemical Analysis; Blood Gas Analysis; Caffe | 2002 |
Topographic quantitative EEG response to acute caffeine withdrawal: a comprehensive analysis of multiple quantitative variables.
Topics: Adolescent; Adult; Alpha Rhythm; Analysis of Variance; Beta Rhythm; Brain Mapping; Caffeine; Cerebra | 2002 |
Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility.
Topics: Biopsy; Caffeine; Cresols; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant | 2003 |
Sensitivity of the Finometer device in detecting acute and medium-term changes in cardiovascular function.
Topics: Adolescent; Adult; Blood Pressure; Blood Pressure Determination; Caffeine; Central Nervous System St | 2003 |
Effect of caffeine ingestion on exhaled nitric oxide measurements in patients with asthma.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analysis of Variance; Anti-Asthmatic Agents; Anti-Inf | 2004 |
Enhanced stimulant and metabolic effects of combined ephedrine and caffeine.
Topics: Adolescent; Adult; Area Under Curve; Biological Availability; Blood Pressure; Caffeine; Cardiovascul | 2004 |
Effect of caffeine supplementation on haematological and biochemical variables in elite soccer players under physical stress conditions.
Topics: Adult; Analysis of Variance; Anthropometry; Biomarkers; Blood Chemical Analysis; Caffeine; Creatine | 2007 |
Effect of a pre-exercise energy supplement on the acute hormonal response to resistance exercise.
Topics: Adult; Amino Acids, Essential; Analysis of Variance; Area Under Curve; Blood Chemical Analysis; Caff | 2008 |
Caffeine clearance study in hepatocellular carcinoma.
Topics: Adult; Aged; Caffeine; Carcinoma, Hepatocellular; Female; Humans; Liver; Liver Cirrhosis; Liver Func | 1999 |
Effect of compound sequence on bitterness enhancement.
Topics: Administration, Oral; Adult; Area Under Curve; Caffeine; Drug Administration Schedule; Drug Interact | 2001 |
Caffeine clearance in patients with chronic viral hepatitis: before and after interferon therapy.
Topics: Administration, Oral; Adult; Caffeine; Chromatography, High Pressure Liquid; Female; Hepatitis B, Ch | 2001 |
Prediction of malignant hyperthermia susceptibility in low-risk subjects. An epidemiologic investigation of caffeine halothane contracture responses. The North American Malignant Hyperthermia Registry.
Topics: Adolescent; Adult; Aged; Biopsy; Caffeine; Child; Contracture; Disease Susceptibility; Female; Halot | 1992 |
156 other studies available for caffeine and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
Different techniques for overlapped UV spectra resolution of some co-administered drugs with paracetamol in their combined pharmaceutical dosage forms.
Topics: Acetaminophen; Caffeine; Diclofenac; Linear Models; Models, Chemical; Orphenadrine; Reproducibility | 2020 |
Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve.
Topics: Caffeine; Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; T | 2019 |
Solvent and temperature effect of accelerated solvent extraction (ASE) coupled with ultra-high-pressure liquid chromatography (UHPLC-PDA) for the determination of methyl xanthines in commercial tea and coffee.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coffee; Sensitivity and Specificity; Solvents; Tea; | 2020 |
An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma.
Topics: Biosensing Techniques; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Syste | 2020 |
Caffeine Delays Retinal Neurovascular Coupling during Dark to Light Adaptation in Healthy Eyes Revealed by Optical Coherence Tomography Angiography.
Topics: Adaptation, Ocular; Adult; Age Factors; Caffeine; Dark Adaptation; Female; Fluorescein Angiography; | 2020 |
Simultaneous Determination of Paracetamol, Propyphenazone and Caffeine in Presence of Paracetamol Impurities Using Dual-Mode Gradient HPLC and TLC Densitometry Methods.
Topics: Acetaminophen; Aminophenols; Antipyrine; Caffeine; Chromatography, High Pressure Liquid; Chromatogra | 2021 |
Simultaneous quantification of caffeine and chlorogenic acid in coffee green beans and varietal classification of the samples by HPLC-DAD coupled with chemometrics.
Topics: Caffeine; Chlorogenic Acid; Chromatography, High Pressure Liquid; Coffee; Least-Squares Analysis; Se | 2018 |
Molecular imaging of the ATM kinase activity.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Benzeneacetamides; Caffeine; Cell Cycle Proteins; C | 2013 |
HPLC-DAD determination of seven antioxidants and caffeine in different phytopharmaceuticals.
Topics: Antioxidants; Caffeine; Camellia sinensis; Chromatography, High Pressure Liquid; Chromatography, Rev | 2014 |
Caffeine monitoring in biological fluids by solid surface fluorescence using membranes modified with nanotubes.
Topics: Caffeine; Calibration; Female; Filtration; Humans; Male; Membranes, Artificial; Nanotubes, Carbon; N | 2013 |
Make caffeine visible: a fluorescent caffeine "traffic light" detector.
Topics: Biosensing Techniques; Caffeine; Fluorescent Dyes; Microfluidic Analytical Techniques; Nuclear Magne | 2013 |
Xanthine derivatives quantification in serum by capillary zone electrophoresis.
Topics: Buffers; Caffeine; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Limit of Detection; Repro | 2014 |
Digitally enhanced thin layer chromatography: further development and some applications in isotopic chemistry.
Topics: Anthraquinones; Caffeine; Carotenoids; Chromatography, Thin Layer; Image Processing, Computer-Assist | 2013 |
Microclimate next to the skin: influence on percutaneous absorption of caffeine (ex-vivo study).
Topics: Administration, Cutaneous; Adult; Air Conditioning; Caffeine; Ecosystem; Environment, Controlled; Eq | 2014 |
Caffeine electrochemical sensor using imprinted film as recognition element based on polypyrrole, sol-gel, and gold nanoparticles hybrid nanocomposite modified pencil graphite electrode.
Topics: Caffeine; Conductometry; Electrodes; Equipment Design; Equipment Failure Analysis; Gold; Graphite; M | 2014 |
Validation of caffeine dehydrogenase from Pseudomonas sp. strain CBB1 as a suitable enzyme for a rapid caffeine detection and potential diagnostic test.
Topics: Bacterial Proteins; Beverages; Caffeine; Food Analysis; Humans; Indicators and Reagents; Milk, Human | 2014 |
Serum caffeine concentrations and short-term outcomes in premature infants of ⩽29 weeks of gestation.
Topics: Caffeine; Chronic Disease; Gestational Age; Hospital Charges; Humans; Infant, Premature; Length of S | 2015 |
Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Linear Models; Phen | 2015 |
Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative study.
Topics: Blood Specimen Collection; Caffeine; Chromatography, Gas; Dried Blood Spot Testing; Healthy Voluntee | 2015 |
Multiresidue determination of pesticides in tea by gas chromatography-tandem mass spectrometry.
Topics: Acetonitriles; Caffeine; Chemical Precipitation; Food Analysis; Food Contamination; Gas Chromatograp | 2015 |
Caffeine does not significantly reduce the sensitivity of vasodilator stress MPI: Rebuttal.
Topics: Caffeine; Exercise Test; Myocardial Perfusion Imaging; Sensitivity and Specificity; Vasodilator Agen | 2016 |
Caffeine reduces the sensitivity of vasodilator MPI for the detection of myocardial ischaemia: Pro.
Topics: Administration, Oral; Caffeine; Drug Interactions; Evidence-Based Medicine; Humans; Myocardial Ische | 2016 |
Clinical associations with immature breathing in preterm infants: part 2-periodic breathing.
Topics: Caffeine; Cohort Studies; Electric Impedance; Enterocolitis, Necrotizing; Female; Gestational Age; H | 2016 |
Biodosimetry for High-Dose Exposures Based on Dicentric Analysis in Lymphocytes Released from the G2-Block by Caffeine.
Topics: Biological Assay; Caffeine; Cells, Cultured; Chromosome Aberrations; Cytogenetic Analysis; Dose-Resp | 2016 |
Offline solid-phase extraction for preconcentration of pharmaceuticals and personal care products in environmental water and their simultaneous determination using the reversed phase high-performance liquid chromatography method.
Topics: Acetaminophen; Benzophenones; Caffeine; Carbanilides; Chromatography, High Pressure Liquid; Chromato | 2016 |
The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data - A case study with caffeine.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Caffeine; Calibration; Dose-Response Relat | 2017 |
The automated, accurate and reproducible determination of steady-state permeation parameters from percutaneous permeation data.
Topics: Animals; Automation; Caffeine; Cattle; Diffusion; Mammary Glands, Animal; Models, Biological; Permea | 2008 |
A caffeine-sensitive membrane electrode: previous misleading report and present approach.
Topics: Caffeine; Calibration; Chromatography, High Pressure Liquid; Electrodes; Hydrogen-Ion Concentration; | 2008 |
Simple and rapid colorimetric detection of cofactors of aptazymes using noncrosslinking gold nanoparticle aggregation.
Topics: Biosensing Techniques; Caffeine; Chemistry, Pharmaceutical; Colorimetry; Cross-Linking Reagents; DNA | 2008 |
[Chromatographic determination of caffeine and its metabolites in saliva and plasma].
Topics: Caffeine; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 | 2008 |
Application and analysis of structure-switching aptamers for small molecule quantification.
Topics: Aptamers, Nucleotide; Biosensing Techniques; Caffeine; Nucleic Acid Conformation; Polymerase Chain R | 2009 |
Silica nanoparticle-templated methacrylic acid monoliths for in-line solid-phase extraction-capillary electrophoresis of basic analytes.
Topics: Beverages; Caffeine; Electrophoresis, Capillary; Humans; Ion Exchange; Methacrylates; Nanoparticles; | 2009 |
Rapid qualitative and quantitative ultra high performance liquid chromatography method for simultaneous analysis of twenty nine common phenolic compounds of various structures.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Flavonoids; Phenols; Reproducibility of R | 2010 |
A highly sensitive caffeine immunoassay based on a monoclonal antibody.
Topics: Antibodies, Monoclonal; Caffeine; Food Analysis; Immunoassay; Reproducibility of Results; Sensitivit | 2010 |
[Theanine, EGCG and caffeine determinated by HPLC].
Topics: Caffeine; Catechin; Chromatography, High Pressure Liquid; Glutamates; Sensitivity and Specificity; T | 2010 |
Dynamic modulation of detection window in conducting polymer based biosensors.
Topics: Biosensing Techniques; Caffeine; Conductometry; Equipment Design; Equipment Failure Analysis; Polyme | 2010 |
Preparation of organic-inorganic hybrid silica monolith with octyl and sulfonic acid groups for capillary electrochromatograhpy and application in determination of theophylline and caffeine in beverage.
Topics: Acetonitriles; Beverages; Caffeine; Capillary Electrochromatography; Electroosmosis; Food Analysis; | 2010 |
Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Biopsy; Caffeine; Child; Child, Preschool; Contrac | 2010 |
Development and validation of GC/MS method for determination of pramipexole in rat plasma.
Topics: Animals; Benzothiazoles; Caffeine; Dopamine Agonists; Drug Stability; Gas Chromatography-Mass Spectr | 2011 |
A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cytochrome P-4 | 2011 |
Non-invasive measurement of oxygen saturation in the spinal vein using SWI: quantitative evaluation under conditions of physiological and caffeine load.
Topics: Adult; Caffeine; Female; Humans; Hyperventilation; Male; Oxygen; Reference Values; Respiratory Physi | 2011 |
Rapid methods to determine procyanidins, anthocyanins, theobromine and caffeine in rat tissues by liquid chromatography-tandem mass spectrometry.
Topics: Animals; Anthocyanins; Caffeine; Chromatography, High Pressure Liquid; Male; Proanthocyanidins; Rats | 2011 |
Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype.
Topics: Acetylation; Arylamine N-Acetyltransferase; Caffeine; Case-Control Studies; Ethnicity; Female; Genot | 2011 |
High-temperature reversed-phase liquid chromatography coupled to isotope ratio mass spectrometry.
Topics: Caffeine; Carbon Dioxide; Carbon Isotopes; Chromatography, Reverse-Phase; Equipment Design; Hot Temp | 2011 |
High-resolution mass spectrometry method for the detection, characterization and quantitation of pharmaceuticals in water.
Topics: Caffeine; Chromatography, Liquid; Drinking Water; Drug Stability; Linear Models; Pharmaceutical Prep | 2011 |
UPLC-MS-MS method for simultaneous determination of caffeine, tolbutamide, metoprolol, and dapsone in rat plasma and its application to cytochrome P450 activity study in rats.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dapsone; Dr | 2013 |
Fluorescence sensing of caffeine in aqueous solution with carbazole-based probe and imaging application in live cells.
Topics: Caffeine; Candida albicans; Carbazoles; Cell Survival; Fluorescent Dyes; Microscopy, Fluorescence; M | 2012 |
Determination of stimulants using gas chromatography/high-resolution time-of-flight mass spectrometry and a soft ionization source.
Topics: Caffeine; Central Nervous System Stimulants; Cocaine; Codeine; Dopamine Uptake Inhibitors; Equipment | 2012 |
Quality assurance in immunoassay performance--comparison of different enzyme immunoassays for the determination of caffeine in consumer products.
Topics: Alkaline Phosphatase; Animals; Antibodies, Monoclonal; Benzidines; Beverages; Caffeine; Chromatograp | 2013 |
Vasoactive intestinal peptide-stimulated Cl- secretion: activation of cAMP-dependent K+ channels.
Topics: Caffeine; Cell Line; Chlorides; Cyclic AMP-Dependent Protein Kinases; Electric Conductivity; Humans; | 2002 |
Reproducibility of in vitro contracture test results in patients tested for malignant hyperthermia susceptibility.
Topics: Adult; Anesthetics, Inhalation; Biopsy; Caffeine; Disease Susceptibility; Female; Halothane; Humans; | 2002 |
A biosensor for theophylline based on fluorescence detection of ligand-induced hammerhead ribozyme cleavage.
Topics: Base Pairing; Base Sequence; Binding Sites; Biosensing Techniques; Caffeine; Fluorescence Resonance | 2002 |
Determination of caffeine as a tracer of sewage effluent in natural waters by on-line solid-phase extraction and liquid chromatography with diode-array detection.
Topics: Automation; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Envir | 2002 |
Trace determination of caffeine in surface water samples by liquid chromatography--atmospheric pressure chemical ionization--mass spectrometry (LC-APCI-MS).
Topics: Atmospheric Pressure; Caffeine; Central Nervous System Stimulants; Chromatography, Liquid; Environme | 2002 |
Inhibitory effects of tea and caffeine on UV-induced carcinogenesis: relationship to enhanced apoptosis and decreased tissue fat.
Topics: Adipose Tissue; Administration, Oral; Administration, Topical; Animals; Anticarcinogenic Agents; Apo | 2002 |
Analysis of adulterants in a traditional herbal medicinal product using liquid chromatography-mass spectrometry-mass spectrometry.
Topics: Caffeine; Chromatography, Liquid; Drug Contamination; Herbal Medicine; Mass Spectrometry; Oxyphenbut | 2003 |
Caffeine clearance in patients with hepatocellular carcinoma after transcatheter oily chemoembolization treatment.
Topics: Adult; Aged; Analysis of Variance; Caffeine; Carcinoma, Hepatocellular; Chemoembolization, Therapeut | 2002 |
Extractionless method for the determination of urinary caffeine metabolites using high-performance liquid chromatography coupled with tandem mass spectrometry.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Reference Standards; Sensitivity and Specifi | 2003 |
[Research into simultaneous spectrophotometric determination of components in cough syrup by principal component regression method].
Topics: Acetaminophen; Aminophenols; Analgesics, Non-Narcotic; Caffeine; Chlorpheniramine; Drug Combinations | 2002 |
[Assay for paracetamol by derivative spectrophotometry in compound amantadine tablets].
Topics: Acetaminophen; Amantadine; Antiviral Agents; Caffeine; Drug Combinations; Pharmaceutical Preparation | 2002 |
[Determination of naoning pian by multi-wavelength linear regression method].
Topics: Analgesics, Non-Narcotic; Antipyrine; Caffeine; Drug Combinations; Linear Models; Pharmaceutical Pre | 2001 |
A rapid high-performance liquid chromatographic method for the simultaneous quantitation of aspirin, salicylic acid, and caffeine in effervescent tablets.
Topics: Aspirin; Caffeine; Chromatography, High Pressure Liquid; Reference Standards; Reproducibility of Res | 2003 |
Sequential injection chromatographic determination of paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets.
Topics: Acetaminophen; Aspirin; Caffeine; Chromatography; Indicators and Reagents; Sensitivity and Specifici | 2004 |
A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes.
Topics: Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; D | 2004 |
Simultaneous determination of caffeine, theophylline and theobromine in human plasma by on-line solid-phase extraction coupled to reversed-phase chromatography.
Topics: Buffers; Caffeine; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Methano | 2004 |
Charge competition and the linear dynamic range of detection in electrospray ionization mass spectrometry.
Topics: Caffeine; Models, Chemical; Reserpine; Sensitivity and Specificity; Spectrometry, Mass, Electrospray | 2004 |
Separation, pre-concentration, and HPLC analysis of methylxanthines in urine samples.
Topics: Caffeine; Calibration; Chromatography, High Pressure Liquid; Humans; Molecular Structure; Reproducib | 2004 |
Monitoring bronchodilators with direct injection.
Topics: Bronchodilator Agents; Caffeine; Calibration; Chromatography, Liquid; Humans; Reproducibility of Res | 2005 |
[Determination of catechins and caffeine in tea and tea beverages by high-performance liquid chromatography].
Topics: Caffeine; Camellia sinensis; Catechin; Chromatography, High Pressure Liquid; Sensitivity and Specifi | 2005 |
Stir bar sorptive extraction based on restricted access material for the direct extraction of caffeine and metabolites in biological fluids.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and | 2005 |
Content uniformity and dissolution tests of triplicate mixtures by a double divisor-ratio spectra derivative method.
Topics: Acetaminophen; Aspirin; Caffeine; Chlorpheniramine; Chromatography, High Pressure Liquid; Reproducib | 2005 |
Advanced oxidation of caffeine in water: on-line and real-time monitoring by electrospray ionization mass spectrometry.
Topics: Automation; Caffeine; Chromatography, High Pressure Liquid; Environmental Monitoring; Gas Chromatogr | 2005 |
Polyphenol levels in human urine after intake of six different polyphenol-rich beverages.
Topics: Adult; Beverages; Biomarkers; Cacao; Caffeine; Calibration; Case-Control Studies; Chromatography, Hi | 2005 |
Separation of caffeine and theophylline in poly(dimethylsiloxane) microchannel electrophoresis with electrochemical detection.
Topics: Animals; Caffeine; Dimethylpolysiloxanes; Electrochemistry; Electrophoresis, Capillary; Hydrogen-Ion | 2005 |
Off-line direct deposition gas chromatography/surface-enhanced Raman scattering and the ramifications for on-line measurements.
Topics: Caffeine; Chromatography, Gas; Computer Systems; Microchemistry; Online Systems; Phenols; Reproducib | 2005 |
Heritability and genetic covariation of sensitivity to PROP, SOA, quinine HCl, and caffeine.
Topics: Adolescent; Adult; Caffeine; Child; Female; Genetic Variation; Humans; Inheritance Patterns; Male; M | 2006 |
Determination of acidic drugs and caffeine in municipal wastewaters and receiving waters by gas chromatography-ion trap tandem mass spectrometry.
Topics: Acids; Caffeine; Calibration; Gas Chromatography-Mass Spectrometry; Pharmaceutical Preparations; Ref | 2006 |
A simple webcam-based approach for the measurement of rodent locomotion and other behavioural parameters.
Topics: Algorithms; Amphetamine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Diz | 2006 |
Reliability of total overnight salivary caffeine assessment (TOSCA) for liver function evaluation in compensated cirrhotic patients.
Topics: Adult; Caffeine; Case-Control Studies; Chromatography, High Pressure Liquid; Humans; Liver Cirrhosis | 2006 |
Development of a multicommuted flow-through optosensor for the determination of a ternary pharmaceutical mixture.
Topics: Antipyrine; Buffers; Caffeine; Flow Injection Analysis; Methanol; Pharmaceutical Preparations; Repro | 2007 |
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High | 2007 |
A preliminary investigation into the use of biosensors to screen stomach contents for selected poisons and drugs.
Topics: Biosensing Techniques; Caffeine; Escherichia coli; Forensic Pathology; Gastrointestinal Contents; Hu | 2007 |
Stereospecific determination of cis- and trans-resveratrol in rat plasma by HPLC: application to pharmacokinetic studies.
Topics: Animals; Caffeine; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Molecular Stru | 2007 |
Development of a biosensor for caffeine.
Topics: Biosensing Techniques; Caffeine; Calibration; Chromatography, High Pressure Liquid; Enzymes, Immobil | 2007 |
Investigation of the advanced functionalities of a hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometer.
Topics: Caffeine; Pharmaceutical Preparations; Reproducibility of Results; Reserpine; Sensitivity and Specif | 2007 |
Liquid chromatography/electrospray ionization tandem mass spectrometry assay for determination of nicotine and metabolites, caffeine and arecoline in breast milk.
Topics: Arecoline; Caffeine; Chromatography, High Pressure Liquid; Humans; Milk, Human; Nicotine; Reproducib | 2007 |
Determination of caffeine in coffee products by dynamic complexation with 3,4-dimethoxycinnamate and separation by CZE.
Topics: Anions; Beverages; Binding Sites; Caffeine; Chlorogenic Acid; Cinnamates; Coffee; Electric Conductiv | 2007 |
An improved application for the enzyme multipled immunoassay technique for caffeine, amikacin, and methotrexate assays on the Dade-Behring Dimension RxL Max clinical chemistry system.
Topics: Amikacin; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Caffeine; Central Nervous System S | 2007 |
Rapid determination of caffeine in one drop of beverages and foods using drop-to-drop solvent microextraction with gas chromatography/mass spectrometry.
Topics: Beverages; Caffeine; Calibration; Chemical Fractionation; Chloroform; Food Analysis; Gas Chromatogra | 2007 |
Changes in sensitivity of response distributions to changing reinforcement ratios during exposure to ephedrine, caffeine, and ephedrine-caffeine combinations.
Topics: Analysis of Variance; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Condit | 2007 |
Is electrogustometry useful for screening abnormalities of taste?
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Citric Acid; Electrodiagnosis; Female; Humans; Male; Mass | 2007 |
Quasi-flow injection analysis for rapid determination of caffeine in tea using the sample pre-treatment method with a cartridge column filled with polyvinylpolypyrrolidone.
Topics: Caffeine; Chromatography, High Pressure Liquid; Flow Injection Analysis; Povidone; Reference Standar | 2008 |
Assessing caffeine exposure in pregnant women.
Topics: Adult; Biomarkers; Caffeine; Diet Records; Feeding Behavior; Female; Humans; Pregnancy; Pregnancy Ou | 2008 |
The delta isomer of hexachlorocyclohexane induces rapid release of the myo-inositol-1,4,5-trisphosphate-sensitive Ca2+ store and blocks capacitative Ca2+ entry in rat basophilic leukemia cells.
Topics: Adenosine Triphosphate; Animals; Antigens; Binding, Competitive; Caffeine; Calcium; Calcium-Transpor | 1995 |
A method for the separation of delta bilirubin using Cibacron Blue affinity chromatography.
Topics: Adult; Benzoates; Bilirubin; Caffeine; Chromatography, Affinity; Chromatography, High Pressure Liqui | 1995 |
Testing vigilance: validity, reliability and sensitivity in methods development.
Topics: Attention; Caffeine; Diphenhydramine; Humans; Reproducibility of Results; Research Design; Sensitivi | 1995 |
Highly sensitive and rapid determination of theophylline, theobromine and caffeine in human plasma and urine by gradient capillary high-performance liquid chromatography-frit-fast atom bombardment mass spectrometry.
Topics: Caffeine; Capillary Action; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results | 1995 |
Rapid high-performance liquid chromatographic determination of vancomycin in human plasma.
Topics: Acetaminophen; Aspirin; Caffeine; Chromatography, High Pressure Liquid; Humans; Quality Control; Sen | 1995 |
Thapsigargin-sensitive Ca(2+)-ATPases account for Ca2+ uptake to inositol 1,4,5-trisphosphate-sensitive and caffeine-sensitive Ca2+ stores in adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cattle; | 1995 |
Application of an enzyme-multiplied immunoassay technique for determination of caffeine elimination kinetics as a test of liver function in clinically normal dogs.
Topics: Administration, Oral; Animals; Caffeine; Dogs; Enzyme Multiplied Immunoassay Technique; Evaluation S | 1994 |
Inhibitory effects of caffeine on secretagogue-induced catecholamine secretion from adrenal chromaffin cells of the guinea-pig.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adrenal Glands; Animals; Bucladesine; Caffein | 1994 |
Determination of ten beta-blockers in urine by micellar electrokinetic capillary chromatography.
Topics: Adrenergic beta-Antagonists; Caffeine; Chromatography; Gas Chromatography-Mass Spectrometry; Humans; | 1993 |
Different fates of camptothecin-induced replication fork-associated double-strand DNA breaks in mammalian cells.
Topics: Animals; Caffeine; Camptothecin; Cell Line; CHO Cells; Chromosome Aberrations; Cricetinae; DNA; DNA | 1994 |
Caffeine withdrawal: apparent heterologous sensitization to adenosine and prostacyclin actions in human platelets.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adolescent; Adult; Alprostadil; Blood Platelets; Caffe | 1993 |
Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity.
Topics: Amphetamine; Animals; Behavior, Animal; Caffeine; Carbolines; Chlordiazepoxide; Chlorides; Chlorine; | 1993 |
Age-related abnormalities in regulation of the ryanodine receptor in rat fast-twitch muscle.
Topics: Aging; Animals; Antibiotics, Antineoplastic; Binding Sites; Caffeine; Calcium; Calcium Channel Block | 1996 |
Calcium signalling in granule neurones studied in cerebellar slices.
Topics: Acetylcholine; Age Factors; Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channel Agonists; | 1996 |
Simultaneous high-performance liquid chromatographic determination of caffeine and theophylline for routine drug monitoring in human plasma.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reproducibility of Resu | 1996 |
In vitro human masseter muscle hypersensitivity: a possible explanation for increase in masseter tone.
Topics: Caffeine; Calcium; Humans; In Vitro Techniques; Masseter Muscle; Muscle Contraction; Muscle Fibers, | 1996 |
Ryanodine-sensitive component of calcium transients evoked by nerve firing at presynaptic nerve terminals.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Central Nervous System Stimu | 1996 |
Hypogravity increases cyclopiazonic acid sensitivity of rat soleus muscle.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypogravity; Indoles; Male; | 1996 |
Threshold level for theophylline in doping analysis.
Topics: Caffeine; Chromatography, High Pressure Liquid; Doping in Sports; Humans; Male; Reproducibility of R | 1996 |
Rapid, simple and sensitive microassay for skeletal muscle homogenates in the functional assessment of the Ca-release channel of sarcoplasmic reticulum: application to diagnosis of susceptibility to malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases; Disease Models, Animal; | 1997 |
Caffeine urinary metabolite ratios as markers of enzyme activity: a theoretical assessment.
Topics: Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Computer Simulation; Cytochrome P-450 CYP1A2; D | 1996 |
Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Caffeine; Cresols; Disease Susceptibility; Dose-Re | 1997 |
Separation of the N-7 methyltransferase, the key enzyme in caffeine biosynthesis.
Topics: Affinity Labels; Caffeine; Chromatography, Affinity; Coffee; Methyltransferases; Plant Extracts; Pla | 1997 |
Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA.
Topics: Bronchodilator Agents; Caffeine; Cytosine; Magnetic Resonance Spectroscopy; Models, Molecular; Molec | 1997 |
In vitro contracture test for diagnosis of malignant hyperthermia following the protocol of the European MH Group: results of testing patients surviving fulminant MH and unrelated low-risk subjects. The European Malignant Hyperthermia Group.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Biopsy; Caffeine; Child; Child, Preschool; F | 1997 |
2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release.
Topics: Animals; Aorta, Thoracic; Blood Platelets; Boron Compounds; Caffeine; Calcium; Calcium Channels; Cel | 1997 |
The Israeli Diagnostic Center for Malignant Hyperthermia: 7-years' accumulated experience.
Topics: Academies and Institutes; Adult; Aged; Biopsy; Caffeine; Child; Electromyography; Female; Genetic Pr | 1997 |
Discordance between malignant hyperthermia susceptibility and RYR1 mutation C1840T in two Scandinavian MH families exhibiting this mutation.
Topics: Anesthesia; Caffeine; Denmark; Female; Genetic Predisposition to Disease; Halothane; Humans; Male; M | 1997 |
Subnanomolar quantification of caffeine's in vitro metabolites by stable isotope dilution gas chromatography-mass spectrometry.
Topics: Caffeine; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; In Vit | 1998 |
Economic evaluation of oral sumatriptan compared with oral caffeine/ergotamine for migraine.
Topics: Administration, Oral; Caffeine; Cost-Benefit Analysis; Ergotamine; Migraine Disorders; Sensitivity a | 1997 |
Comparison between the European and North American protocols for diagnosis of malignant hyperthermia susceptibility in humans.
Topics: Caffeine; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Sensitivity and Specificity | 1999 |
High-performance liquid chromatographic method for simultaneous determination of [1-methyl-14C]caffeine and its eight major metabolites in rat urine.
Topics: Animals; Caffeine; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzy | 1999 |
Use of caffeine as a probe for rapid determination of cytochrome P-450 CYP1A2 activity in humans.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Sensitivity and Spe | 1998 |
Validation of a high-performance liquid chromatography assay for quantification of caffeine and paraxanthine in human serum in the context of CYP1A2 phenotyping.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Phenotype; Reproduc | 1999 |
[Caffeine skinned fiber tension test: application to the diagnosis of susceptibility to malignant hyperthermia].
Topics: Caffeine; Disease Susceptibility; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contra | 1999 |
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyto | 1999 |
Quantitation of caffeine by capillary zone electrophoresis with end-column amperometric detection at a carbon microdisk array electrode.
Topics: Beverages; Caffeine; Carbon; Electrodes; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentrat | 2000 |
Simultaneous determination of paracetamol, caffeine and acetylsalicylic acid by means of a FI ultraviolet pls multioptosensing device.
Topics: Acetaminophen; Aspirin; Caffeine; Electronic Data Processing; Flow Injection Analysis; Hydrogen-Ion | 1999 |
Study of a molecular imprinting polymer coated BAW bio-mimic sensor and its application to the determination of caffeine in human serum and urine.
Topics: Biosensing Techniques; Caffeine; Humans; Sensitivity and Specificity | 1999 |
On-line coupling of subcritical water extraction with high-performance liquid chromatography via solid-phase trapping.
Topics: Aniline Compounds; Caffeine; Chlorophenols; Chromatography, High Pressure Liquid; Polychlorinated Bi | 2000 |
A high-performance liquid chromatography assay for yohimbine HCl analysis.
Topics: Adrenergic alpha-Antagonists; Caffeine; Calibration; Central Nervous System Stimulants; Hot Temperat | 2000 |
Liquid chromatographic method for the simultaneous determination of caffeine and fourteen caffeine metabolites in urine.
Topics: Adult; Aged; Caffeine; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Refe | 2000 |
Surfactants usable for electrospray ionization mass spectrometry.
Topics: Adrenergic beta-Antagonists; Alkanesulfonic Acids; Caffeine; Caprylates; Chromatography, High Pressu | 2000 |
Development of an automated on-line solid-phase extraction-high-performance liquid chromatographic method for the analysis of aniline, phenol, caffeine and various selected substituted aniline and phenol compounds in aqueous matrices.
Topics: Aniline Compounds; Automation; Caffeine; Chromatography, High Pressure Liquid; Electrochemistry; Phe | 2000 |
Fourier transform infrared determination of caffeine in roasted coffee samples.
Topics: Ammonia; Caffeine; Coffee; Food Handling; Indicators and Reagents; Reproducibility of Results; Sensi | 2000 |
Loss of G2/M arrest correlates with radiosensitization in two human sarcoma cell lines with mutant p53.
Topics: Adenocarcinoma; Alleles; Apoptosis; Blotting, Western; Caffeine; Cell Survival; Combined Modality Th | 2001 |
Misclassification of exposure: coffee as a surrogate for caffeine intake.
Topics: Adult; Aged; Caffeine; Central Nervous System Stimulants; Coffee; Diet; Environmental Exposure; Epid | 2001 |
Fluorescence quenching high-performance thin-layer chromatographic analysis utilizing a scientifically operated charge-coupled device detector.
Topics: Acetaminophen; Aspirin; Autoanalysis; Caffeine; Chromatography, High Pressure Liquid; Chromatography | 2001 |
A simple high-pressure liquid chromatography cotinine assay: validation of smoking status in pregnant women.
Topics: Biomarkers; Caffeine; Chromatography, High Pressure Liquid; Coffee; Cotinine; Creatinine; Female; Hu | 2001 |
Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of biological origin.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and | 2001 |
Improved high-performance liquid chromatography method to determine theobromine and caffeine in cocoa and cocoa products.
Topics: Cacao; Caffeine; Chromatography, High Pressure Liquid; Sensitivity and Specificity; Theobromine; Tim | 2001 |
Testing for malignant hyperthermia.
Topics: Anesthesia; Biopsy; Caffeine; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Sensiti | 2002 |
Use of an automated on-line SPE-HPLC method to monitor caffeine and selected aniline and phenol compounds in aquatic systems of Macedonia-Thrace, Greece.
Topics: Aniline Compounds; Caffeine; Chromatography, High Pressure Liquid; Electrochemistry; Gas Chromatogra | 2001 |
Simultaneous determination of caffeine, theobromine, and theophylline by high-performance liquid chromatography.
Topics: Beverages; Caffeine; Calibration; Chromatography, High Pressure Liquid; Sensitivity and Specificity; | 2002 |
Functional and fluorochrome analysis of an exocytotic mutant yields evidence of store-operated Ca2+ influx in Paramecium.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Cell Line; Cresols; Dextrans; Exocytosis; Fluorescent | 2002 |
Differential activation by Ca2+, ATP and caffeine of cardiac and skeletal muscle ryanodine receptors after block by Mg2+.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Dogs; In Vitro Techniques; Magnesium; Muscle, Sk | 2002 |
Enhanced cytogenetic detection of previous in vivo exposure to mutagens in human lymphocytes after treatment with inhibitors of DNA synthesis and DNA repair in vitro.
Topics: Adult; Caffeine; Cells, Cultured; Chromosome Aberrations; DNA Repair; DNA Replication; Humans; Hydro | 1992 |
Sources of variability in halothane and caffeine contracture tests for susceptibility to malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Caffeine; Child; Contracture; Dose-Response Relationship, Drug; Female; Hal | 1992 |
Sensitivity of transmission probabilities to paternity exclusion in segregation analysis.
Topics: Acetyltransferases; Caffeine; Family Health; Genetic Carrier Screening; Humans; Meiosis; Paternity; | 1992 |
Spatial and dynamic changes in intracellular Ca2+ measured by confocal laser-scanning microscopy in bullfrog sympathetic ganglion cells.
Topics: Aniline Compounds; Animals; Anura; Caffeine; Calcium; Electric Stimulation; Fluorescent Dyes; Gangli | 1991 |
Rapid and sensitive gas-chromatographic determination of caffeine in blood plasma, saliva, and xanthine beverages.
Topics: Adult; Beverages; Caffeine; Chromatography, Gas; Humans; Male; Reference Standards; Reproducibility | 1991 |