caffeine has been researched along with Seizures in 160 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relationship between caffeine, seizures, epilepsy, and anti-seizure drugs is not fully understood." | 9.01 | The Use of Caffeine by People with Epilepsy: the Myths and the Evidence. ( Bauer, PR; Sander, JW, 2019) |
| "PubMed was searched for studies assessing the effects of caffeine on seizure susceptibility, epilepsy, and drug interactions in people and in animal models." | 8.98 | Caffeine and seizures: A systematic review and quantitative analysis. ( Bauer, PR; Sander, JW; Schuitema, I; van Koert, RR; Visser, GH, 2018) |
| "Although caffeine supplementation has a beneficial effect on people with neurological disorders, its implications for oxidative damage related to seizures are not well documented." | 7.79 | Antioxidant activity elicited by low dose of caffeine attenuates pentylenetetrazol-induced seizures and oxidative damage in rats. ( Castro, M; Fighera, MR; Gerbatin, RR; Mota, BC; Rodrigues, FS; Royes, LF; Souza, MA, 2013) |
| "To describe a case of possible caffeine-induced seizure in a patient taking an over-the-counter weight loss supplement." | 7.79 | Potential toxicity of caffeine when used as a dietary supplement for weight loss. ( Brown, S; Odle, B; Pendleton, M; Thomas, CM, 2013) |
| "Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy." | 7.78 | The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. ( Kanda, T; Takizawa, F; Tamura, T; Yamada, K, 2012) |
| "To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 7.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
| "5 g/l in drinking water) on bicuculline- and pentylenetetrazol (PTZ)-induced seizures and c-fos expression were studied in mice." | 7.69 | Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding. ( Fredholm, BB; Georgiev, V; Johansson, B; Kuosmanen, T, 1996) |
| "Caffeine as well as the antiasthmatic drug theophylline can cause seizures when administered to humans or animals in excessive doses." | 7.68 | Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats. ( Levy, G; Zhi, JG, 1990) |
| "5 ug NECA, however the same doses of N6-cyclohexyladenosine (CHA) and 2-chloroadenosine (2 C1-ADO) did not precipitate seizures." | 7.68 | Caffeine-induced seizures: apparent proconvulsant action of N-ethyl carboxamidoadenosine (NECA). ( Durcan, MJ; Morgan, PF, 1990) |
| "Two strains of inbred mice differed significantly in their susceptibility to tonic seizures induced by caffeine and the benzodiazepine inverse agonist, methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM)." | 7.67 | Different genes specify hyporesponsiveness to seizures induced by caffeine and the benzodiazepine inverse agonist, DMCM. ( Abla, KA; Carney, JM; Rennert, OM; Roderick, TH; Seale, TW, 1987) |
| "The median inhibitory and anticonvulsant potencies of seven benzodiazepine (BDZ) agonists and one BDZ antagonist (Ro15-1788) were established by two tests: inhibition of [3H]flunitrazepam receptor binding and prevention of caffeine-induced seizures in mice." | 7.67 | Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice. ( Chweh, AY; Swinyard, EA; Ulloque, RA, 1986) |
| "This study investigates the ability of adenosine antagonists to reverse the anticonvulsant effects of carbamazepine on amygdala-kindled seizures in order to elucidate the possible physiological relevance of the potent effects of carbamazepine on adenosine receptors." | 7.67 | Adenosine antagonists. Lack of effect on the inhibition of kindled seizures in rats by carbamazepine. ( Marangos, PJ; Patel, J; Post, RM; Weiss, SR, 1985) |
| " A tremorogenic dose of harmaline (30 mg/kg intravenously) increased binding by 31%." | 7.66 | Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor. ( Airaksinen, MM; Saano, V, 1982) |
| "Rats were kindled during exposure to caffeine (50 mg/kg) or saline given IP twenty minutes before daily electrical stimulation of the amygdala until 3 kindled amygdaloid seizures (KAS) occurred." | 7.66 | Caffeine modification of kindled amygdaloid seizures. ( Albertson, TE; Joy, RM; Stark, LG, 1983) |
| "The induction of generalized tonic-clinic seizures in mice by the methylxanthine stimulant caffeine is described." | 7.66 | The benzodiazepines and inosine antagonize caffeine-induced seizures. ( Marangos, PJ; Martino, AM; Paul, SM; Skolnick, P, 1981) |
| "A stroke-like event follows seizures which may be responsible for the postictal state and a contributing factor to the development of seizure-induced brain abnormalities and behavioral dysfunction associated with epilepsy." | 5.51 | Caffeine Exacerbates Postictal Hypoxia. ( Gom, RC; Phillips, TJ; Teskey, GC; Wolff, MD, 2019) |
| "We assessed the seizure vulnerability and anxiety responses following the chronic co-administration of, and withdrawal from, caffeine and ethanol in male rats." | 5.48 | Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model. ( Alele, PE; Matovu, D, 2018) |
| "Febrile seizures (FS) is one of the most common convulsive disorders in infants and young children that only occurs during the first years of life in humans, when the cerebellum is still developing." | 5.48 | Cerebellar oxidative stress and fine motor impairment in adolescent rats exposed to hyperthermia-induced seizures is prevented by maternal caffeine intake during gestation and lactation. ( Crespo, M; León-Navarro, DA; Martín, M, 2018) |
| "Seizures and epilepsy are associated with significant disability and substantial treatment costs, yet little is known about primary prevention." | 5.36 | A prospective study of smoking, caffeine, and alcohol as risk factors for seizures or epilepsy in young adult women: data from the Nurses' Health Study II. ( Bromfield, EB; Dworetzky, BA; Kang, JH; Townsend, MK, 2010) |
| "Occurrence of seizures following long-term oral administration of caffeine (0." | 5.35 | Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2008) |
| "Ephedrine is a sympathicomimetic agent that stimulates the central nervous and cardiovascular systems and causes bronchodilatation." | 5.31 | [Ephedrine and ephedra in weight loss products and other preparations]. ( Stricker, BH; van der Hooft, CS, 2002) |
| "Pretreatment with caffeine blocked the anticonvulsant effects of 2-CLA dose-dependently." | 5.30 | Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures. ( Mirnajafi-Zadeh, J; Palizvan, MR; Pourgholami, MH; Rostampour, M, 1997) |
| "To do so, the maximal electroshock seizure test in mice (an experimental model predicting drug efficacy in the treatment of human generalized tonic-clonic seizures) was employed to (1) quantify changes in the protective efficacy and potency of felbamate produced by adjunct drugs and (2) assess the ability of aminophylline and caffeine to affect protective efficacy afforded by a submaximal protective dose of felbamate against maximal electroshock-induced seizures." | 5.30 | Felbamate demonstrates low propensity for interaction with methylxanthines and Ca2+ channel modulators against experimental seizures in mice. ( Borowicz, K; Czuczwar, SJ; Gasior, M; Kleinrok, Z; Przybyłko, M; Swiader, M; Turski, WA, 1998) |
| "We determined tonic-clonic seizure duration in rats given ECS with caffeine (0-175 mg/kg, IP) after a course of one or six daily ECS." | 5.29 | Reduced proconvulsant activity of caffeine in rats after a series of electroconvulsive seizures. ( Fochtmann, L; Francis, A, 1995) |
| "Caffeine has been used clinically to increase seizure length in electroconvulsive treatment (ECT)." | 5.29 | Caffeine augmentation of electroconvulsive seizures. ( Fochtmann, L; Francis, A, 1994) |
| "When isbufylline-pretreated rats were challenged with pentylenetetrazole, the EEG was characterized by a short run of wave discharges (whose duration was shorter than that of other groups)." | 5.28 | Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study. ( Bortot, L; Cutrufo, C; Giachetti, A; Manzini, S, 1992) |
| "In mice, tonic convulsive seizure induced by intravenous administration of caffeine (adenosine A1, A2 receptors antagonist) was significantly potentiated by any one of L-PIA (adenosine A1 receptor agonist), NECA (adenosine A2 receptor agonist) and 2-ClAd (adenosine A1, A2 receptors agonist)." | 5.28 | [Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice]. ( Inano, S, 1992) |
| "A wide spectrum of cardiac arrhythmias was observed during and following the seizures." | 5.26 | Caffeine- and aminophylline-induced seizures. ( Chu, NS, 1981) |
| "Caffeine lengthens electroconvulsive therapy (ECT) seizures but has not been demonstrated to lower seizure threshold, nor to directly improve treatment outcome." | 5.07 | Effects of caffeine pretreatment on measures of seizure impact. ( Farah, A; McCall, WV; Reboussin, DM; Rosenquist, PB, 1994) |
| "The relationship between caffeine, seizures, epilepsy, and anti-seizure drugs is not fully understood." | 5.01 | The Use of Caffeine by People with Epilepsy: the Myths and the Evidence. ( Bauer, PR; Sander, JW, 2019) |
| "PubMed was searched for studies assessing the effects of caffeine on seizure susceptibility, epilepsy, and drug interactions in people and in animal models." | 4.98 | Caffeine and seizures: A systematic review and quantitative analysis. ( Bauer, PR; Sander, JW; Schuitema, I; van Koert, RR; Visser, GH, 2018) |
| "Clinical evidence, in particular the wide use of theophylline as a bronchodilator, suggests that methylxanthines can cause seizures in patients without known underlying epilepsy." | 4.87 | Methylxanthines, seizures, and excitotoxicity. ( Boison, D, 2011) |
| "03 mmol/kg for the induction of seizures), produced a significant reduction in the anticonvulsant effects of carbamazepine, phenobarbital, phenytoin, and valproate against maximal electroshock-induced seizures in mice." | 4.84 | [Caffeine and antiepileptic drugs: experimental and clinical data]. ( Błaszczyk, B; Chrościńska-Krawczyk, M; Czuczwar, SJ; Jankiewicz, K, 2007) |
| "Experimental data indicate that caffeine (CAF) can reduce the anticonvulsant activity of antiepileptic drugs (AEDs) in animal models of seizures." | 4.12 | Effect of caffeine on the anticonvulsant action of pregabalin against electroconvulsions in mice. ( Chwedorowicz, R; Czuczwar, SJ; Raszewski, G; Łukawski, K, 2022) |
| " The compound had a pronounced anticonvulsant effect, significantly reducing the mortality of mice in models of seizures induced by pentylenetetrazole, picrotoxin, strychnine, and caffeine." | 4.12 | Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico. ( Georgiyants, V; Kayal, WE; Mishchenko, M; Severina, H; Shtrygol, D; Shtrygol, S; Zalevskyi, S, 2022) |
| "We induced generalized tonic-clonic seizures with the administration of 60 mg/kg pentylenetetrazole (PTZ) in male Wistar Albino rats." | 3.85 | The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model. ( Ateş, N; Dede, F; Eraldemir, FC; Karadenizli, S; Özsoy, ÖD; Şahin, D, 2017) |
| "The influence of caffeine on epileptic seizures remains a matter of debate." | 3.81 | Effect of caffeine and adenosine receptor ligands on the expression of spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg (GAERS). ( Faure, JB; Germé, K; Koning, E; Nehlig, A, 2015) |
| "Treatment of apnea of prematurity with methylxanthines like caffeine, aminophylline or theophylline can evoke hippocampal seizures." | 3.81 | Methylxanthine-evoked perturbation of spontaneous and evoked activities in isolated newborn rat hippocampal networks. ( Ballanyi, K; Kantor, C; Kilb, W; Kuribayashi, J; Luhmann, HJ; Mildenberger, E; Ruangkittisakul, A; Sharopov, S, 2015) |
| "Although caffeine supplementation has a beneficial effect on people with neurological disorders, its implications for oxidative damage related to seizures are not well documented." | 3.79 | Antioxidant activity elicited by low dose of caffeine attenuates pentylenetetrazol-induced seizures and oxidative damage in rats. ( Castro, M; Fighera, MR; Gerbatin, RR; Mota, BC; Rodrigues, FS; Royes, LF; Souza, MA, 2013) |
| "Clinical stimulation of preterm infant breathing with methylxanthines like caffeine and theophylline can evoke seizures." | 3.79 | Methylxanthines do not affect rhythmogenic preBötC inspiratory network activity but impair bursting of preBötC-driven motoneurons. ( Ballanyi, K; Iizuka, M; Kuribayashi, J; Leung, V; Panaitescu, B; Ruangkittisakul, A, 2013) |
| "To describe a case of possible caffeine-induced seizure in a patient taking an over-the-counter weight loss supplement." | 3.79 | Potential toxicity of caffeine when used as a dietary supplement for weight loss. ( Brown, S; Odle, B; Pendleton, M; Thomas, CM, 2013) |
| "Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy." | 3.78 | The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. ( Kanda, T; Takizawa, F; Tamura, T; Yamada, K, 2012) |
| "Treatment with ginsenosides attenuated KA-induced seizures and oxidative stress in the synaptosome, and reduced synaptic vesicles at the presynaptic terminals dose-dependently." | 3.75 | Ginsenosides attenuate kainic acid-induced synaptosomal oxidative stress via stimulation of adenosine A(2A) receptors in rat hippocampus. ( Chae, JS; Jeong, JH; Kim, AY; Kim, HC; Kim, SC; Kim, WK; Ko, KH; Koh, YH; Nah, SY; Shin, EJ; Yen, TP; Yoon, HJ, 2009) |
| "To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy." | 3.73 | Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats. ( Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S, 2005) |
| "The effects of toluene on the sensitivity to seizures induced by aminophylline were investigated." | 3.72 | Toluene exposure increases aminophylline-induced seizure susceptibility in mice. ( Chan, MH; Chen, HH, 2003) |
| " longiflorus (CLE) was investigated for sedative, anticonvulsant and behaviour modifying activity using thiopental sleeping, caffeine induced convulsion and forced swimming depression tests." | 3.71 | Sedative, anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam. ( Büyükokuroğlu, ME; Demirezer, LO; Güvenalp, Z, 2002) |
| "The use of cocaine is associated with the occurrence of seizures." | 3.71 | Psychostimulants and epilepsy. ( Albano, C; Zagnoni, PG, 2002) |
| "We tested the effect of caffeine, on hyperoxia-induced seizures." | 3.69 | Caffeine attenuates CNS oxygen toxicity in rats. ( Bitterman, N; Schaal, S, 1995) |
| "Early developmental exposure to caffeine in rats results in decreased susceptibility to certain chemically-induced seizures in the adult." | 3.69 | Neonatal caffeine exposure alters seizure susceptibility in rats in an age-related manner. ( Guillet, R, 1995) |
| "We evaluated the protective activity (expressed as ED50 values in mg/kg of phenobarbital (PB, 120 min before testing) and valproate (30 min) alone or combined with caffeine in male mice with seizures induced by maximal electroshock (MES)." | 3.69 | Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation. ( Borowicz, K; Buszewicz, G; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1996) |
| "The anticonvulsant activities of intraperitoneally (IP) given carbamazepine (CBZ) or diphenylhydantoin (DPH), expressed as their respective ED50 values in mg/kg, were assessed after caffeine (CAFF) treatment against maximal electroshock-induced seizures in mice." | 3.69 | Chronic caffeine and the anticonvulsant potency of antiepileptic drugs against maximal electroshock. ( Borowicz, K; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1996) |
| "5 g/l in drinking water) on bicuculline- and pentylenetetrazol (PTZ)-induced seizures and c-fos expression were studied in mice." | 3.69 | Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding. ( Fredholm, BB; Georgiev, V; Johansson, B; Kuosmanen, T, 1996) |
| "Caffeine as well as the antiasthmatic drug theophylline can cause seizures when administered to humans or animals in excessive doses." | 3.68 | Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats. ( Levy, G; Zhi, JG, 1990) |
| "5 ug NECA, however the same doses of N6-cyclohexyladenosine (CHA) and 2-chloroadenosine (2 C1-ADO) did not precipitate seizures." | 3.68 | Caffeine-induced seizures: apparent proconvulsant action of N-ethyl carboxamidoadenosine (NECA). ( Durcan, MJ; Morgan, PF, 1990) |
| " The effects on amygdala-triggered seizures of papaverine, adenosine, 2-chloroadenosine, and the adenosine antagonists, isobutylmethylxanthine and caffeine, were also investigated at seizure threshold." | 3.67 | Adenosine modulation of amygdala kindling. ( Dragunow, M; Goddard, GV, 1984) |
| "Numerous case reports have documented that phenylpropanolamine (PPA) stimulates the central nervous system with symptoms ranging from anxiety and hallucinations to grand mal seizures produced by overdoses." | 3.67 | Phenylpropanolamine potentiates caffeine neurotoxicity in rats. ( Walker, JS, 1989) |
| "Two strains of inbred mice differed significantly in their susceptibility to tonic seizures induced by caffeine and the benzodiazepine inverse agonist, methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM)." | 3.67 | Different genes specify hyporesponsiveness to seizures induced by caffeine and the benzodiazepine inverse agonist, DMCM. ( Abla, KA; Carney, JM; Rennert, OM; Roderick, TH; Seale, TW, 1987) |
| "The median inhibitory and anticonvulsant potencies of seven benzodiazepine (BDZ) agonists and one BDZ antagonist (Ro15-1788) were established by two tests: inhibition of [3H]flunitrazepam receptor binding and prevention of caffeine-induced seizures in mice." | 3.67 | Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice. ( Chweh, AY; Swinyard, EA; Ulloque, RA, 1986) |
| "Theophylline can cause life-threatening seizures when administered in excessive doses." | 3.67 | Caffeine as a potential risk factor for theophylline neurotoxicity. ( Levy, G; Yasuhara, M, 1988) |
| "This study investigated the effects of acute and chronic caffeine treatment on behavior in the social interaction, holeboard and home-cage aggression tests and on proconvulsant actions with pentylenetetrazol." | 3.67 | Behavioral effects of acute and chronic administration of caffeine in the rat. ( Baldwin, HA; File, SE; Johnston, AL; Wilks, LJ, 1988) |
| "We report two infants with near miss sudden infant death syndrome events exhibiting seizure disorders after caffeine treatment, suggesting there is an infant subgroup diagnosed as near miss sudden infant death syndrome who have apnoea possibly with seizures whose seizure threshold may be lowered by central nervous system stimulants like caffeine." | 3.67 | Apnoea and seizures. ( Aranda, JV; Davis, JM; Metrakos, K, 1986) |
| "This study investigates the ability of adenosine antagonists to reverse the anticonvulsant effects of carbamazepine on amygdala-kindled seizures in order to elucidate the possible physiological relevance of the potent effects of carbamazepine on adenosine receptors." | 3.67 | Adenosine antagonists. Lack of effect on the inhibition of kindled seizures in rats by carbamazepine. ( Marangos, PJ; Patel, J; Post, RM; Weiss, SR, 1985) |
| " A tremorogenic dose of harmaline (30 mg/kg intravenously) increased binding by 31%." | 3.66 | Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor. ( Airaksinen, MM; Saano, V, 1982) |
| "Rats were kindled during exposure to caffeine (50 mg/kg) or saline given IP twenty minutes before daily electrical stimulation of the amygdala until 3 kindled amygdaloid seizures (KAS) occurred." | 3.66 | Caffeine modification of kindled amygdaloid seizures. ( Albertson, TE; Joy, RM; Stark, LG, 1983) |
| "The induction of generalized tonic-clinic seizures in mice by the methylxanthine stimulant caffeine is described." | 3.66 | The benzodiazepines and inosine antagonize caffeine-induced seizures. ( Marangos, PJ; Martino, AM; Paul, SM; Skolnick, P, 1981) |
| "Twenty seizures were judged as probably related, 13 possibly related, and 10 as unrelated to DS use." | 2.43 | Seizures reported in association with use of dietary supplements. ( Haller, CA; Meier, KH; Olson, KR, 2005) |
| "The abrupt onset of intractable seizures needs to be anticipated in order to appropriately manage the victims and to prevent the adverse outcome." | 2.40 | Acute caffeine ingestion fatalities: management issues. ( Beard, D; Chucovich, V; Hathaway, D; Seale, C; Shum, S, 1997) |
| "Enprofylline is a more potent smooth muscle relaxant and antiasthmatic drug than theophylline but does not produce, e." | 2.37 | Effects of enprofylline and theophylline may show the role of adenosine. ( Andersson, KE; Kjellin, G; Persson, CG, 1986) |
| "Seizures are common neurological emergencies in the elderly that are frequently provoked." | 1.91 | Seizures provoked by over-the-counter cough and cold medications in an elderly patient: a case report. ( Alattiya, MK; Hammamy, RA; Joudeh, AI, 2023) |
| "Seizures were evoked by adding PTZ solution to obtain a final concentration of 20 mM." | 1.91 | Optimization of the Zebrafish Larvae Pentylenetetrazol-Induced Seizure Model for the Study of Caffeine and Topiramate Interactions. ( Bartoszek, A; Fornal, E; Kozub, A; Trzpil, A, 2023) |
| "Median baseline seizure frequencies/28 days were 10." | 1.72 | Efficacy of cenobamate by focal seizure subtypes: Post-hoc analysis of a phase 3, multicenter, open-label study. ( Ferrari, L; Kamin, M; Rosenfeld, WE, 2022) |
| "Caffeine is a psychoactive substance used worldwide." | 1.72 | Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats. ( Araújo, DB; Azevedo, JEC; Barbas, LAL; da Silva, ALM; Hamoy, AO; Hamoy, M; Lopes, DCF; Lopez, MEC; Mello, VJ; Nascimento, CP; Pereira, RG; Rodrigues, SF; Vieira, LR, 2022) |
| "Tramadol (TR) is an analgesic drug used to treat moderate-to-severe pain but it induces seizure even at therapeutic doses." | 1.62 | Caffeine attenuates seizure and brain mitochondrial disruption induced by Tramadol: the role of adenosinergic pathway. ( Ahangar, N; Bameri, B; Fallah, M; Mohammadi, H; Samadi, M; Shaki, F, 2021) |
| "A stroke-like event follows seizures which may be responsible for the postictal state and a contributing factor to the development of seizure-induced brain abnormalities and behavioral dysfunction associated with epilepsy." | 1.51 | Caffeine Exacerbates Postictal Hypoxia. ( Gom, RC; Phillips, TJ; Teskey, GC; Wolff, MD, 2019) |
| "We assessed the seizure vulnerability and anxiety responses following the chronic co-administration of, and withdrawal from, caffeine and ethanol in male rats." | 1.48 | Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model. ( Alele, PE; Matovu, D, 2018) |
| "Febrile seizures (FS) is one of the most common convulsive disorders in infants and young children that only occurs during the first years of life in humans, when the cerebellum is still developing." | 1.48 | Cerebellar oxidative stress and fine motor impairment in adolescent rats exposed to hyperthermia-induced seizures is prevented by maternal caffeine intake during gestation and lactation. ( Crespo, M; León-Navarro, DA; Martín, M, 2018) |
| "Electroencephalogram seizure duration increased by 24." | 1.48 | Caffeine Sodium Benzoate for Electroconvulsive Therapy Augmentation. ( Bozymski, KM; Crouse, EL; Pandurangi, AK; Potter, TG; Venkatachalam, V, 2018) |
| "Serious complications included 2 seizures and 1 episode of ventricular tachycardia." | 1.48 | Energy drink exposures reported to Texas poison centers: Analysis of adverse incidents in relation to total sales, 2010-2014. ( Baeza, S; Borron, SW; Herrera, J; Kingston, RL; Larson, J; Watts, SH, 2018) |
| " Although increase in seizure duration was achieved for the majority of the ECT sessions, no dose-response correlation could be made." | 1.43 | Pretreatment With Caffeine Citrate to Increase Seizure Duration During Electroconvulsive Therapy: A Case Series. ( Biglow, M; Chandra, S; Pica, T; Pinkhasov, A, 2016) |
| "Caffeine acts as a central nervous stimulant by blocking A1 and A2A adenosine receptors." | 1.39 | Is dietary caffeine involved in seizure precipitation? ( Bråthen, G; Brodtkorb, E; Helde, G; Reimers, A; Samsonsen, C, 2013) |
| "Small studies have associated energy drinks-beverages that typically contain high concentrations of caffeine and other stimulants-with serious adverse health events." | 1.39 | An analysis of energy-drink toxicity in the National Poison Data System. ( Arheart, KL; Benson, BE; Bronstein, AC; Franco, VI; Hershorin, ER; Lipshultz, SE; Schaechter, JL; Seifert, SA; Seifert, SM, 2013) |
| "During drug development, seizure threshold tests are widely used to identify potential proconvulsant activity of investigational drugs." | 1.38 | Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models. ( Bankstahl, JP; Bankstahl, M; Bloms-Funke, P; Löscher, W, 2012) |
| "Seizures and epilepsy are associated with significant disability and substantial treatment costs, yet little is known about primary prevention." | 1.36 | A prospective study of smoking, caffeine, and alcohol as risk factors for seizures or epilepsy in young adult women: data from the Nurses' Health Study II. ( Bromfield, EB; Dworetzky, BA; Kang, JH; Townsend, MK, 2010) |
| "Ethanol-induced retrograde amnesia was investigated using a new odor-recognition test." | 1.35 | Alcohol-induced retrograde memory impairment in rats: prevention by caffeine. ( Cormack, LK; Feinberg, LM; Schallert, K; Schallert, T; Spinetta, MJ; Stroud, C; Woodlee, MT, 2008) |
| "This type of seizures never appeared in caffeine-treated 25-day-old animals." | 1.35 | Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in rats. ( Kubová, H; Mares, P; Tchekalarova, J, 2009) |
| "Occurrence of seizures following long-term oral administration of caffeine (0." | 1.35 | Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2008) |
| "Seizure control is often affected by seizure threshold lowering behaviours." | 1.32 | Caffeinated beverages and decreased seizure control. ( Kaufman, KR; Sachdeo, RC, 2003) |
| "Ephedrine is a sympathicomimetic agent that stimulates the central nervous and cardiovascular systems and causes bronchodilatation." | 1.31 | [Ephedrine and ephedra in weight loss products and other preparations]. ( Stricker, BH; van der Hooft, CS, 2002) |
| "The role of morphine-dependence on the seizure susceptibility has been evaluated with models of pentylenetetrazol (PTZ)-kindling and acute convulsions induced by PTZ, N-methyl-D-aspartic acid (NMDA), picrotoxin and caffeine in adult male rats." | 1.31 | Chemical kindling and seizure susceptibility in morphine dependent rats. ( Atapour, N; Kalantaripour, TP; Niazi, M; Nourpanah, M, 2000) |
| "Pretreatment with caffeine blocked the anticonvulsant effects of 2-CLA dose-dependently." | 1.30 | Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures. ( Mirnajafi-Zadeh, J; Palizvan, MR; Pourgholami, MH; Rostampour, M, 1997) |
| "Substance abuse is well documented among bodybuilders and weight lifters keen to enhance their performance." | 1.30 | Caffeine toxicity in a bodybuilder. ( FitzSimmons, CR; Kidner, N, 1998) |
| "To do so, the maximal electroshock seizure test in mice (an experimental model predicting drug efficacy in the treatment of human generalized tonic-clonic seizures) was employed to (1) quantify changes in the protective efficacy and potency of felbamate produced by adjunct drugs and (2) assess the ability of aminophylline and caffeine to affect protective efficacy afforded by a submaximal protective dose of felbamate against maximal electroshock-induced seizures." | 1.30 | Felbamate demonstrates low propensity for interaction with methylxanthines and Ca2+ channel modulators against experimental seizures in mice. ( Borowicz, K; Czuczwar, SJ; Gasior, M; Kleinrok, Z; Przybyłko, M; Swiader, M; Turski, WA, 1998) |
| "We specifically measured seizure duration, sensitivity to proconvulsant actions of caffeine, and relative refractoriness to postictal induction of further seizures, all of which showed significant interstrain variability." | 1.30 | Genetic approaches to the neurobiology of electroconvulsive therapy. ( Fochtmann, LJ, 1998) |
| "The headaches were treated with chlorpromazine with a good result." | 1.30 | [Intractable vomiting, convulsions and megaloblastic anemia: anamnesis, key to diagnosis]. ( de Torrenté, A; Humair, L; Schlaeppi, M, 1999) |
| "Investigations were carried out to evaluate the effect of acute and chronic administration of both black and green tea on three models of experimentally induced convulsions in mice." | 1.30 | Proconvulsive effect of tea (Camellia sinensis) in mice. ( Das, M; Ganguly, DK; Gomes, A; Vedasiromoni, JR, 1999) |
| "The latency to stage 4 seizure was increased only at the highest dose of 2-CLA (100 nM), while even at this dose no significant change in seizure stage could be seen." | 1.30 | Anticonvulsant action of 2-chloroadenosine injected focally into the perirhinal cortex in amygdaloid kindled rats. ( Fallahi, M; Mirnajafi-Zadeh, J; Palizvan, MR; Pourgholami, MH; Rostampour, M, 1999) |
| "There were also gender differences in seizure susceptibility." | 1.29 | Neonatal caffeine exposure and seizure susceptibility in adult rats. ( Dunham, L; Guillet, R, 1995) |
| "We determined tonic-clonic seizure duration in rats given ECS with caffeine (0-175 mg/kg, IP) after a course of one or six daily ECS." | 1.29 | Reduced proconvulsant activity of caffeine in rats after a series of electroconvulsive seizures. ( Fochtmann, L; Francis, A, 1995) |
| "Caffeine has been used clinically to increase seizure length in electroconvulsive treatment (ECT)." | 1.29 | Caffeine augmentation of electroconvulsive seizures. ( Fochtmann, L; Francis, A, 1994) |
| "When isbufylline-pretreated rats were challenged with pentylenetetrazole, the EEG was characterized by a short run of wave discharges (whose duration was shorter than that of other groups)." | 1.28 | Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study. ( Bortot, L; Cutrufo, C; Giachetti, A; Manzini, S, 1992) |
| "In mice, tonic convulsive seizure induced by intravenous administration of caffeine (adenosine A1, A2 receptors antagonist) was significantly potentiated by any one of L-PIA (adenosine A1 receptor agonist), NECA (adenosine A2 receptor agonist) and 2-ClAd (adenosine A1, A2 receptors agonist)." | 1.28 | [Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice]. ( Inano, S, 1992) |
| "Caffeine pretreatment significantly increased the incidence of overt seizures induced by either cocaine or amphetamine." | 1.28 | Potentiation of cocaine and d-amphetamine toxicity with caffeine. ( Albertson, TE; Derlet, RW; Tseng, JC, 1992) |
| "Experiments examining seizure sensitivity were conducted on adult male offspring exposed to diazepam at 1." | 1.28 | Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex. ( Bitran, D; Kellogg, CK; Primus, RJ, 1991) |
| " Loss of righting ability was scored at 1, 3, 5 min post dosing and at 5 min intervals thereafter for 20 min." | 1.27 | Interstrain variation in acute toxic response to caffeine among inbred mice. ( Carney, JM; Johnson, P; Rennert, OM; Seale, TW, 1984) |
| "Deaths followed severe tetanic convulsions: some animals had transient convulsions and survived, and others presented no acute toxicity." | 1.27 | Caffeine distribution in acute toxic response among inbred mice. ( Bonati, M; Bortolotti, A; Filippeschi, S; Garattini, S; Gaspari, F; Jiritano, L; Puidgemont, A, 1985) |
| "The frequency of sound-induced seizures after 12." | 1.26 | Reduction in caffeine toxicity by acetaminophen. ( Deng, JF; Rall, TW; Spyker, DA; Steward, O, 1982) |
| "A wide spectrum of cardiac arrhythmias was observed during and following the seizures." | 1.26 | Caffeine- and aminophylline-induced seizures. ( Chu, NS, 1981) |
| "Animals died from a characteristic spastic paralysis after intravenous injection of the toxin." | 1.25 | A myotoxin secreted by some piscivorous Conus species. ( Freeman, SE; Turner, RJ, 1972) |
| "Glycogen was depleted only by amphetamine-like compounds or by bemegride-induced convulsions." | 1.25 | Physiological and drug-induced changes in the glycogen content of mouse brain. ( Hutchins, DA; Rogers, KJ, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 64 (40.00) | 18.7374 |
| 1990's | 28 (17.50) | 18.2507 |
| 2000's | 22 (13.75) | 29.6817 |
| 2010's | 38 (23.75) | 24.3611 |
| 2020's | 8 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chwedorowicz, R | 4 |
| Łukawski, K | 4 |
| Raszewski, G | 4 |
| Czuczwar, SJ | 10 |
| Rosenfeld, WE | 1 |
| Ferrari, L | 1 |
| Kamin, M | 1 |
| Azevedo, JEC | 1 |
| da Silva, ALM | 1 |
| Vieira, LR | 1 |
| Nascimento, CP | 1 |
| Pereira, RG | 1 |
| Rodrigues, SF | 1 |
| Hamoy, AO | 1 |
| Mello, VJ | 1 |
| Araújo, DB | 1 |
| Barbas, LAL | 1 |
| Lopez, MEC | 1 |
| Lopes, DCF | 1 |
| Hamoy, M | 1 |
| Shtrygol, S | 3 |
| Zalevskyi, S | 3 |
| Mishchenko, M | 3 |
| Shtrygol, D | 3 |
| Severina, H | 3 |
| Kayal, WE | 3 |
| Georgiyants, V | 3 |
| Alattiya, MK | 1 |
| Joudeh, AI | 1 |
| Hammamy, RA | 1 |
| Bartoszek, A | 1 |
| Trzpil, A | 1 |
| Kozub, A | 1 |
| Fornal, E | 1 |
| Yavuz, M | 1 |
| Albayrak, N | 1 |
| Özgür, M | 1 |
| Gülçebi İdriz Oğlu, M | 1 |
| Çavdar, S | 1 |
| Onat, F | 1 |
| Phillips, TJ | 1 |
| Gom, RC | 1 |
| Wolff, MD | 1 |
| Teskey, GC | 1 |
| Dede, F | 1 |
| Karadenizli, S | 1 |
| Özsoy, ÖD | 1 |
| Eraldemir, FC | 1 |
| Şahin, D | 1 |
| Ateş, N | 1 |
| Matovu, D | 1 |
| Alele, PE | 1 |
| Crespo, M | 1 |
| León-Navarro, DA | 1 |
| Martín, M | 1 |
| van Koert, RR | 1 |
| Bauer, PR | 2 |
| Schuitema, I | 1 |
| Sander, JW | 2 |
| Visser, GH | 1 |
| Bozymski, KM | 1 |
| Potter, TG | 1 |
| Venkatachalam, V | 1 |
| Pandurangi, AK | 1 |
| Crouse, EL | 1 |
| Borron, SW | 1 |
| Watts, SH | 1 |
| Herrera, J | 1 |
| Larson, J | 1 |
| Baeza, S | 1 |
| Kingston, RL | 1 |
| Rath, S | 1 |
| Shaikh, A | 1 |
| Narwal, P | 1 |
| Gupta, A | 1 |
| Cyranoski, D | 1 |
| Samadi, M | 1 |
| Shaki, F | 1 |
| Bameri, B | 1 |
| Fallah, M | 1 |
| Ahangar, N | 1 |
| Mohammadi, H | 1 |
| Souza, MA | 1 |
| Mota, BC | 1 |
| Gerbatin, RR | 1 |
| Rodrigues, FS | 1 |
| Castro, M | 1 |
| Fighera, MR | 1 |
| Royes, LF | 1 |
| Samsonsen, C | 1 |
| Bråthen, G | 1 |
| Reimers, A | 1 |
| Helde, G | 1 |
| Brodtkorb, E | 1 |
| Tchekalarova, J | 4 |
| Kubová, H | 5 |
| Mareš, P | 5 |
| Seifert, SM | 2 |
| Seifert, SA | 2 |
| Schaechter, JL | 2 |
| Bronstein, AC | 2 |
| Benson, BE | 2 |
| Hershorin, ER | 2 |
| Arheart, KL | 2 |
| Franco, VI | 2 |
| Lipshultz, SE | 2 |
| Silva, CG | 1 |
| Métin, C | 1 |
| Fazeli, W | 1 |
| Machado, NJ | 1 |
| Darmopil, S | 1 |
| Launay, PS | 1 |
| Ghestem, A | 1 |
| Nesa, MP | 1 |
| Bassot, E | 1 |
| Szabó, E | 1 |
| Baqi, Y | 1 |
| Müller, CE | 2 |
| Tomé, AR | 1 |
| Ivanov, A | 1 |
| Isbrandt, D | 1 |
| Zilberter, Y | 1 |
| Cunha, RA | 2 |
| Esclapez, M | 1 |
| Bernard, C | 1 |
| Panaitescu, B | 1 |
| Kuribayashi, J | 2 |
| Ruangkittisakul, A | 2 |
| Leung, V | 1 |
| Iizuka, M | 1 |
| Ballanyi, K | 2 |
| Barker, KA | 1 |
| Seger, D | 1 |
| Tchekalarova, JD | 1 |
| Pinkhasov, A | 1 |
| Biglow, M | 1 |
| Chandra, S | 1 |
| Pica, T | 1 |
| Germé, K | 1 |
| Faure, JB | 1 |
| Koning, E | 1 |
| Nehlig, A | 1 |
| Sharopov, S | 1 |
| Kantor, C | 1 |
| Mildenberger, E | 1 |
| Luhmann, HJ | 1 |
| Kilb, W | 1 |
| Jargiełło-Baszak, M | 2 |
| Chrościńska-Krawczyk, M | 3 |
| Andres-Mach, M | 1 |
| Łuszczki, JJ | 1 |
| Faingold, CL | 1 |
| Randall, M | 1 |
| Kommajosyula, SP | 1 |
| Butragueño Laiseca, L | 1 |
| Toledo Del Castillo, B | 1 |
| Miranda Herrero, MC | 1 |
| Spinetta, MJ | 1 |
| Woodlee, MT | 1 |
| Feinberg, LM | 1 |
| Stroud, C | 1 |
| Schallert, K | 1 |
| Cormack, LK | 1 |
| Schallert, T | 1 |
| Shin, EJ | 1 |
| Koh, YH | 1 |
| Kim, AY | 1 |
| Nah, SY | 1 |
| Jeong, JH | 1 |
| Chae, JS | 1 |
| Kim, SC | 1 |
| Yen, TP | 1 |
| Yoon, HJ | 1 |
| Kim, WK | 1 |
| Ko, KH | 1 |
| Kim, HC | 1 |
| Shen, HY | 1 |
| Li, T | 1 |
| Boison, D | 2 |
| Dworetzky, BA | 1 |
| Bromfield, EB | 1 |
| Townsend, MK | 1 |
| Kang, JH | 1 |
| Cognato, GP | 1 |
| Agostinho, PM | 1 |
| Hockemeyer, J | 1 |
| Souza, DO | 1 |
| Wong, K | 1 |
| Stewart, A | 1 |
| Gilder, T | 1 |
| Wu, N | 1 |
| Frank, K | 1 |
| Gaikwad, S | 1 |
| Suciu, C | 1 |
| Dileo, J | 1 |
| Utterback, E | 1 |
| Chang, K | 1 |
| Grossman, L | 1 |
| Cachat, J | 1 |
| Kalueff, AV | 1 |
| Wałek, M | 1 |
| Tylus, B | 1 |
| Babu, KM | 1 |
| Zuckerman, MD | 1 |
| Cherkes, JK | 1 |
| Hack, JB | 1 |
| Bankstahl, M | 1 |
| Bankstahl, JP | 1 |
| Bloms-Funke, P | 1 |
| Löscher, W | 1 |
| Yamada, K | 1 |
| Takizawa, F | 1 |
| Tamura, T | 1 |
| Kanda, T | 1 |
| Maiga, DD | 1 |
| Seyni, H | 1 |
| Sidikou, A | 1 |
| Azouma, A | 1 |
| Pendleton, M | 1 |
| Brown, S | 1 |
| Thomas, CM | 1 |
| Odle, B | 1 |
| van der Hooft, CS | 1 |
| Stricker, BH | 1 |
| Fureman, BE | 1 |
| Jinnah, HA | 1 |
| Hess, EJ | 1 |
| Büyükokuroğlu, ME | 1 |
| Demirezer, LO | 1 |
| Güvenalp, Z | 1 |
| Kaufman, KR | 1 |
| Sachdeo, RC | 1 |
| MERCIER, J | 1 |
| LESPAGNOL, C | 1 |
| Gordon, N | 1 |
| Newton, RW | 1 |
| CHEN, G | 1 |
| ENSOR, CR | 1 |
| PORTMAN, R | 1 |
| FIORETTILUCARELLI, L | 1 |
| SEKI, S | 1 |
| REMEZOVA, ES | 1 |
| SAFONOVA, SA | 1 |
| CHAO, NT | 1 |
| LI, PJ | 1 |
| BESSON, H | 1 |
| DEBAY, A | 1 |
| Chan, MH | 1 |
| Chen, HH | 1 |
| Doughty, C | 1 |
| Walker, A | 1 |
| Brenchley, J | 1 |
| Haller, CA | 1 |
| Meier, KH | 1 |
| Olson, KR | 1 |
| Hoexter, MQ | 1 |
| Rosa, PS | 1 |
| Tufik, S | 1 |
| Mello, LE | 1 |
| McNamara, R | 1 |
| Kerans, A | 1 |
| O'Neill, B | 1 |
| Harkin, A | 1 |
| Röggla, G | 1 |
| Moser, B | 1 |
| Wammanda, RD | 1 |
| Jankiewicz, K | 1 |
| Błaszczyk, B | 1 |
| El Yacoubi, M | 1 |
| Ledent, C | 1 |
| Parmentier, M | 1 |
| Costentin, J | 1 |
| Vaugeois, JM | 1 |
| Skolnick, P | 3 |
| Paul, SM | 2 |
| Snyder, SH | 1 |
| Sklar, P | 1 |
| Saano, V | 1 |
| Airaksinen, MM | 1 |
| Deng, JF | 1 |
| Spyker, DA | 1 |
| Rall, TW | 1 |
| Steward, O | 1 |
| Vellucci, SV | 1 |
| Webster, RA | 1 |
| Lapin, IP | 2 |
| Albertson, TE | 2 |
| Joy, RM | 1 |
| Stark, LG | 1 |
| Dragunow, M | 1 |
| Goddard, GV | 1 |
| Seale, TW | 3 |
| Johnson, P | 1 |
| Carney, JM | 3 |
| Rennert, OM | 3 |
| Marangos, PJ | 3 |
| Martino, AM | 1 |
| Bernstein, E | 1 |
| Diskant, BM | 1 |
| Mueller, SM | 1 |
| Solow, EB | 1 |
| Banner, W | 1 |
| Czajka, PA | 1 |
| Chu, NS | 1 |
| Guillet, R | 2 |
| Dunham, L | 1 |
| Francis, A | 2 |
| Fochtmann, L | 2 |
| Rosenquist, PB | 1 |
| McCall, WV | 1 |
| Farah, A | 1 |
| Reboussin, DM | 1 |
| Bitterman, N | 1 |
| Schaal, S | 1 |
| Gasior, M | 3 |
| Borowicz, K | 3 |
| Buszewicz, G | 1 |
| Kleinrok, Z | 3 |
| Johansson, B | 1 |
| Georgiev, V | 1 |
| Kuosmanen, T | 1 |
| Fredholm, BB | 1 |
| Pourgholami, MH | 3 |
| Mirnajafi-Zadeh, J | 3 |
| Behzadi, J | 1 |
| Shum, S | 1 |
| Seale, C | 1 |
| Hathaway, D | 1 |
| Chucovich, V | 1 |
| Beard, D | 1 |
| Rostampour, M | 2 |
| Palizvan, MR | 2 |
| FitzSimmons, CR | 1 |
| Kidner, N | 1 |
| Swiader, M | 1 |
| Przybyłko, M | 1 |
| Turski, WA | 1 |
| Fochtmann, LJ | 1 |
| Schlaeppi, M | 1 |
| Humair, L | 1 |
| de Torrenté, A | 1 |
| Gomes, A | 1 |
| Das, M | 1 |
| Vedasiromoni, JR | 1 |
| Ganguly, DK | 1 |
| Fallahi, M | 1 |
| Jin, W | 1 |
| Sugaya, A | 1 |
| Tsuda, T | 1 |
| Ohguchi, H | 1 |
| Sugaya, E | 1 |
| Atapour, N | 1 |
| Kalantaripour, TP | 1 |
| Nourpanah, M | 1 |
| Niazi, M | 1 |
| Kockler, DR | 1 |
| McCarthy, MW | 1 |
| Lawson, CL | 1 |
| Zagnoni, PG | 1 |
| Albano, C | 1 |
| Ammon, HP | 1 |
| Künkel, H | 1 |
| Cutrufo, C | 1 |
| Bortot, L | 1 |
| Giachetti, A | 1 |
| Manzini, S | 1 |
| Inano, S | 1 |
| Karler, R | 1 |
| Calder, LD | 1 |
| Derlet, RW | 1 |
| Tseng, JC | 1 |
| Bitran, D | 1 |
| Primus, RJ | 1 |
| Kellogg, CK | 1 |
| Whitcomb, K | 1 |
| Lupica, CR | 1 |
| Rosen, JB | 1 |
| Berman, RF | 1 |
| Dietrich, AM | 1 |
| Mortensen, ME | 1 |
| Zhi, JG | 1 |
| Levy, G | 3 |
| Morgan, PF | 2 |
| Durcan, MJ | 1 |
| Walker, JS | 1 |
| Turgeon, SM | 1 |
| Leccese, AP | 1 |
| Deckert, J | 2 |
| Jacobson, KA | 1 |
| Daly, JW | 1 |
| Abla, KA | 1 |
| Roderick, TH | 1 |
| Traversa, U | 1 |
| de Angelis, L | 1 |
| Della Loggia, R | 1 |
| Bertolissi, M | 1 |
| Nardini, G | 1 |
| Vertua, R | 1 |
| Chweh, AY | 1 |
| Ulloque, RA | 1 |
| Swinyard, EA | 1 |
| Bolton, VE | 1 |
| Leicht, CH | 1 |
| Scanlon, TS | 1 |
| Persson, CG | 1 |
| Andersson, KE | 1 |
| Kjellin, G | 1 |
| Gleiter, CH | 1 |
| Nutt, DJ | 1 |
| Yasuhara, M | 2 |
| File, SE | 1 |
| Baldwin, HA | 1 |
| Johnston, AL | 1 |
| Wilks, LJ | 1 |
| Walsh, I | 1 |
| Wasserman, GS | 1 |
| Mestad, P | 1 |
| Lanman, RC | 1 |
| Popoli, P | 1 |
| Benedetti, M | 1 |
| Scotti de Carolis, A | 1 |
| Lerer, B | 1 |
| Shapira, B | 1 |
| Drexler, H | 1 |
| Calev, A | 1 |
| Newman, ME | 1 |
| Burdette, LJ | 1 |
| Dyer, RS | 1 |
| Flux, M | 1 |
| Coffey, CE | 1 |
| Weiner, RD | 1 |
| Hinkle, PE | 1 |
| Cress, M | 1 |
| Daughtry, G | 1 |
| Wilson, WH | 1 |
| Davis, JM | 1 |
| Metrakos, K | 1 |
| Aranda, JV | 1 |
| Weiss, SR | 1 |
| Post, RM | 1 |
| Patel, J | 1 |
| Bonati, M | 1 |
| Jiritano, L | 1 |
| Bortolotti, A | 1 |
| Gaspari, F | 1 |
| Filippeschi, S | 1 |
| Puidgemont, A | 1 |
| Garattini, S | 1 |
| Lebovitz, RM | 1 |
| Freeman, SE | 1 |
| Turner, RJ | 1 |
| Mennear, JH | 1 |
| Rudzik, AD | 1 |
| Boissier, JR | 1 |
| Simon, P | 1 |
| Villeneuve, A | 1 |
| Larousse, C | 1 |
| Chiba, S | 1 |
| Nagawa, Y | 1 |
| Yui, T | 1 |
| Frank, GB | 2 |
| Jhamandas, K | 2 |
| Kita, T | 2 |
| Hata, T | 2 |
| Murakami, T | 2 |
| Kimura, R | 2 |
| Murata, T | 2 |
| Sattin, A | 1 |
| Roussinov, KS | 2 |
| Lazarova, MB | 1 |
| Atanassova-Shopova, S | 2 |
| Matsuda, K | 1 |
| Saad, SF | 1 |
| Hach, B | 1 |
| Heim, F | 1 |
| Fujii, T | 1 |
| Sasaki, H | 1 |
| Nishimura, H | 1 |
| Hutchins, DA | 1 |
| Rogers, KJ | 1 |
| Wilson, DE | 1 |
| Chernov, HI | 1 |
| Bernard, PS | 1 |
| Partyka, DA | 1 |
| Barbaz, BS | 1 |
| DeStevens, G | 1 |
| Lugovskiĭ, BK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Cenobamate Adjunctive Therapy in Subjects With PGTC Seizures[NCT03678753] | Phase 3 | 170 participants (Anticipated) | Interventional | 2018-09-21 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for caffeine and Seizures
| Article | Year |
|---|---|
Caffeine and seizures: A systematic review and quantitative analysis.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Drug Interactions; Epilepsy; | 2018 |
The Use of Caffeine by People with Epilepsy: the Myths and the Evidence.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Epilepsy; Humans; Seizures | 2019 |
Early caffeine exposure: transient and long-term consequences on brain excitability.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Caffeine; Humans; Mice; Purinergic P1 Receptor An | 2014 |
Methylxanthines, seizures, and excitotoxicity.
Topics: Adenosine; Animals; Caffeine; Humans; Neurotoxins; Seizures; Theophylline; Xanthines | 2011 |
Caffeine and the anticonvulsant potency of antiepileptic drugs: experimental and clinical data.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Drug | 2011 |
[Convulsive crisis in Tramadol and caffeine abusers: about 8 cases and review of the literature].
Topics: Adolescent; Adult; Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Humans; Retrospe | 2012 |
Glucose transporter type1 (GLUT-1) deficiency.
Topics: Anticonvulsants; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Caffeine; Central Nervous System | 2003 |
Seizures reported in association with use of dietary supplements.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Caffeine; Diagnosis, Differential; Dieta | 2005 |
[Caffeine and antiepileptic drugs: experimental and clinical data].
Topics: Animals; Anticonvulsants; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactio | 2007 |
The mechanism(s) of action of the benzodiazepines.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Caffeine; Carbolines; C | 1981 |
Acute caffeine ingestion fatalities: management issues.
Topics: Acute Disease; Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Diet; Drug Overdose; | 1997 |
Effects of enprofylline and theophylline may show the role of adenosine.
Topics: Adenosine; Animals; Asthma; Brain; Bronchodilator Agents; Caffeine; Diuresis; Fatty Acids, Nonesteri | 1986 |
Near-fatal caffeine intoxication treated with peritoneal dialysis.
Topics: Caffeine; Child, Preschool; Female; Gastrointestinal Hemorrhage; Humans; Intubation, Intratracheal; | 1987 |
1 trial available for caffeine and Seizures
| Article | Year |
|---|---|
Effects of caffeine pretreatment on measures of seizure impact.
Topics: Aged; Caffeine; Electrocardiography; Electroconvulsive Therapy; Electroencephalography; Female; Hear | 1994 |
146 other studies available for caffeine and Seizures
| Article | Year |
|---|---|
Effect of caffeine on the anticonvulsant action of pregabalin against electroconvulsions in mice.
Topics: Animals; Anticonvulsants; Brain; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2022 |
Efficacy of cenobamate by focal seizure subtypes: Post-hoc analysis of a phase 3, multicenter, open-label study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Caffeine; Carbamates; Chlorophenols; Double-Blind Method; | 2022 |
Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats.
Topics: Animals; Anticonvulsants; Caffeine; Diazepam; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Ra | 2022 |
Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice.
Topics: Animals; Anticonvulsants; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2023 |
Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice.
Topics: Animals; Anticonvulsants; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2023 |
Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice.
Topics: Animals; Anticonvulsants; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2023 |
Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice.
Topics: Animals; Anticonvulsants; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2023 |
Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice.
Topics: Animals; Anticonvulsants; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2023 |
Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice.
Topics: Animals; Anticonvulsants; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2023 |
Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice.
Topics: Animals; Anticonvulsants; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2023 |
Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice.
Topics: Animals; Anticonvulsants; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2023 |
Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice.
Topics: Animals; Anticonvulsants; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2023 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Seizures provoked by over-the-counter cough and cold medications in an elderly patient: a case report.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Caffeine; Cough; Humans; Male; Pseudoephedrine; Seizures | 2023 |
Optimization of the Zebrafish Larvae Pentylenetetrazol-Induced Seizure Model for the Study of Caffeine and Topiramate Interactions.
Topics: Animals; Caffeine; Chromatography, Liquid; Larva; Pentylenetetrazole; Seizures; Tandem Mass Spectrom | 2023 |
The effect of prenatal and postnatal caffeine exposure on pentylentetrazole induced seizures in the non-epileptic and epileptic offsprings.
Topics: Animals; Brain; Caffeine; Calcium Channels, T-Type; Epilepsy, Absence; Female; Male; Pentylenetetraz | 2019 |
Caffeine Exacerbates Postictal Hypoxia.
Topics: Adenosine; Animals; CA1 Region, Hippocampal; Caffeine; Dose-Response Relationship, Drug; Hypoxia; Ki | 2019 |
The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model.
Topics: Adenosine; Animals; Brain; Caffeine; Central Nervous System Stimulants; Convulsants; Cytokines; Dise | 2017 |
Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model.
Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Ethanol; Male; Pentylenetetrazole; Rats; Rats, Sprague | 2018 |
Cerebellar oxidative stress and fine motor impairment in adolescent rats exposed to hyperthermia-induced seizures is prevented by maternal caffeine intake during gestation and lactation.
Topics: 5'-Nucleotidase; Adenosine; Animals; Caffeine; Cerebellum; Female; Fever; Gait; Lactation; Mothers; | 2018 |
Caffeine Sodium Benzoate for Electroconvulsive Therapy Augmentation.
Topics: Adult; Aged; Arterial Pressure; Benzoates; Caffeine; Central Nervous System Stimulants; Combined Mod | 2018 |
Energy drink exposures reported to Texas poison centers: Analysis of adverse incidents in relation to total sales, 2010-2014.
Topics: Caffeine; Child; Child, Preschool; Commerce; Energy Drinks; Female; Humans; Male; Retrospective Stud | 2018 |
New-onset headaches secondary to spontaneous intracranial hypotension.
Topics: Anticoagulants; Anticonvulsants; Bed Rest; Blood Patch, Epidural; Brain Infarction; Caffeine; Centra | 2018 |
China expands surveillance of sewage to police illegal drug use.
Topics: Caffeine; China; Cities; Humans; Illicit Drugs; Nicotine; Police; Seizures; Sewage; Wastewater | 2018 |
Caffeine attenuates seizure and brain mitochondrial disruption induced by Tramadol: the role of adenosinergic pathway.
Topics: Animals; Brain; Caffeine; Disease Models, Animal; Mice; Mitochondria; Protein Carbonylation; Seizure | 2021 |
Antioxidant activity elicited by low dose of caffeine attenuates pentylenetetrazol-induced seizures and oxidative damage in rats.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Caffeine; Central Nervous System Stimulants; Convulsa | 2013 |
Is dietary caffeine involved in seizure precipitation?
Topics: Adult; Caffeine; Central Nervous System Stimulants; Female; Humans; Interviews as Topic; Male; Middl | 2013 |
Effects of caffeine on cortical epileptic afterdischarges in adult rats are modulated by postnatal treatment.
Topics: Aging; Animals; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Disease Models, Animal | 2013 |
An analysis of energy-drink toxicity in the National Poison Data System.
Topics: Adolescent; Adult; Alcoholic Beverages; Arrhythmias, Cardiac; Caffeine; Central Nervous System Stimu | 2013 |
Adenosine receptor antagonists including caffeine alter fetal brain development in mice.
Topics: Aging; Animals; Animals, Newborn; Brain; Caffeine; Cell Movement; Cognition Disorders; Disease Susce | 2013 |
Methylxanthines do not affect rhythmogenic preBötC inspiratory network activity but impair bursting of preBötC-driven motoneurons.
Topics: Animals; Caffeine; Inhalation; Interneurons; Motor Neurons; Neural Pathways; Organ Culture Technique | 2013 |
In reply to "Interpretation of 'An analysis of energy-drink toxicity in the National Poison Data System'".
Topics: Alcoholic Beverages; Arrhythmias, Cardiac; Caffeine; Central Nervous System Stimulants; Energy Drink | 2014 |
Interpretation of "An analysis of energy-drink toxicity in the National Poison Data System".
Topics: Alcoholic Beverages; Arrhythmias, Cardiac; Caffeine; Central Nervous System Stimulants; Energy Drink | 2014 |
Pretreatment With Caffeine Citrate to Increase Seizure Duration During Electroconvulsive Therapy: A Case Series.
Topics: Aged; Aged, 80 and over; Caffeine; Central Nervous System Stimulants; Citrates; Combined Modality Th | 2016 |
Effect of caffeine and adenosine receptor ligands on the expression of spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg (GAERS).
Topics: Animals; Anticonvulsants; Brain; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2015 |
Methylxanthine-evoked perturbation of spontaneous and evoked activities in isolated newborn rat hippocampal networks.
Topics: Animals; Animals, Newborn; CA3 Region, Hippocampal; Caffeine; Calcium; Nerve Net; Pyramidal Cells; R | 2015 |
Influence of caffeine on the protective activity of gabapentin and topiramate in a mouse model of generalized tonic-clonic seizures.
Topics: Amines; Animals; Anticonvulsants; Caffeine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, | 2016 |
Susceptibility to seizure-induced sudden death in DBA/2 mice is altered by adenosine.
Topics: Adenosine; Animals; Caffeine; Death, Sudden; Disease Models, Animal; Disease Susceptibility; Dose-Re | 2016 |
Energy drinks as a trigger factor for seizures in paediatric patients: A case report.
Topics: Caffeine; Child; Electroencephalography; Energy Drinks; Humans; Male; Seizures | 2019 |
Alcohol-induced retrograde memory impairment in rats: prevention by caffeine.
Topics: Adenosine A2 Receptor Antagonists; Amnesia, Retrograde; Animals; Caffeine; Central Nervous System De | 2008 |
Ginsenosides attenuate kainic acid-induced synaptosomal oxidative stress via stimulation of adenosine A(2A) receptors in rat hippocampus.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Caffeine; Dose-Response Relationsh | 2009 |
Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Central Nervous System Stimu | 2009 |
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Cause of De | 2010 |
A prospective study of smoking, caffeine, and alcohol as risk factors for seizures or epilepsy in young adult women: data from the Nurses' Health Study II.
Topics: Adult; Age Distribution; Alcohol Drinking; Caffeine; Epilepsy; Female; Health Status; Humans; Incide | 2010 |
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Diseas | 2010 |
Effects of early postnatal caffeine exposure on seizure susceptibility of rats are age- and model-dependent.
Topics: Age Factors; Analysis of Variance; Animals; Caffeine; Convulsants; Disease Susceptibility; Dose-Resp | 2010 |
Modeling seizure-related behavioral and endocrine phenotypes in adult zebrafish.
Topics: Animals; Behavior, Animal; Caffeine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fema | 2010 |
First-Onset Seizure After Use of an Energy Drink [corrected].
Topics: Adolescent; Caffeine; Diagnosis, Differential; Emergency Service, Hospital; Energy Drinks; Follow-Up | 2011 |
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; | 2012 |
The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.
Topics: Age Factors; Animals; Anti-Allergic Agents; Brain; Caffeine; Central Nervous System Stimulants; Dibe | 2012 |
Potential toxicity of caffeine when used as a dietary supplement for weight loss.
Topics: Adult; Caffeine; Dietary Supplements; Epilepsy, Tonic-Clonic; Female; Humans; Nonprescription Drugs; | 2013 |
[Ephedrine and ephedra in weight loss products and other preparations].
Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Arrhythmias, Cardiac; Caffeine; Centr | 2002 |
Triggers of paroxysmal dyskinesia in the calcium channel mouse mutant tottering.
Topics: Animals; Anticonvulsants; Caffeine; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Sign | 2002 |
Sedative, anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Caffeine; Central Nervous System Stimulants; | 2002 |
Caffeinated beverages and decreased seizure control.
Topics: Beverages; Caffeine; Central Nervous System Stimulants; Humans; Male; Middle Aged; Seizures | 2003 |
[Investigations on the anti-convulsant properties of apocaffeine].
Topics: Caffeine; Convulsants; Seizures | 1952 |
Anticonvulsant effects of certain CNS depressants in convulsions induced by strychnine, metrazol or caffeine.
Topics: Anticonvulsants; Caffeine; Central Nervous System Depressants; Pentylenetetrazole; Seizures; Strychn | 1956 |
[5-Hydroxytryptamine & experimental caffeine-induced convulsions in mice].
Topics: Animals; Caffeine; Mice; Seizures; Serotonin; Serotonin Agents | 1958 |
[Convulsive action of caffeine introduced into the CSF of dogs].
Topics: Animals; Caffeine; Dogs; Seizures | 1961 |
[TREATMENT OF PATIENTS WITH EPILEPSY WITH FREQUENT PETIT MAL SEIZURES].
Topics: Anticonvulsants; Caffeine; Drug Therapy; Epilepsy; Epilepsy, Absence; Humans; Phenobarbital; Seizure | 1964 |
[THE ANTICONVULSANT ACTIVITY OF ARISAEMA JAPONICUM BL].
Topics: Anticonvulsants; Arisaema; Caffeine; Electric Injuries; Epilepsy; Mice; Pentylenetetrazole; Pharmaco | 1964 |
[POTENTIATION BY THEOPHYLLINE AND CAFFEINE OF THE CONVULSANT EFFECTS AND TOXICITY OF ISONIAZID].
Topics: Caffeine; Convulsants; Isoniazid; Pharmacology; Rats; Research; Seizures; Theophylline; Toxicology | 1964 |
Toluene exposure increases aminophylline-induced seizure susceptibility in mice.
Topics: Aminophylline; Animals; Benzaldehydes; Bronchodilator Agents; Caffeine; Disease Models, Animal; Drug | 2003 |
Herbal mind altering substances: an unknown quantity?
Topics: Adolescent; Caffeine; Drug Interactions; Ephedrine; Female; Hallucinogens; Humans; Plant Preparation | 2004 |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats.
Topics: Adenosine; Animals; Caffeine; Coffea; Disease Models, Animal; Dose-Response Relationship, Drug; Drin | 2005 |
Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love").
Topics: 3,4-Methylenedioxyamphetamine; Animals; Area Under Curve; Behavior, Animal; Body Temperature; Brain | 2006 |
Effects of postnatal caffeine exposure on seizure susceptibility in developing rats.
Topics: Age Factors; Aminophylline; Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Caffeine; Cent | 2007 |
Seizures in a night club.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Beverages; Caffeine; Drug Interactions | 2007 |
Hyperactivity and inattention--a successful response to table coffee.
Topics: Attention Deficit Disorder with Hyperactivity; Caffeine; Central Nervous System Stimulants; Child, P | 2007 |
Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine.
Topics: Analysis of Variance; Animals; Caffeine; Disease Models, Animal; Disease Susceptibility; Dose-Respon | 2008 |
Behavioral and molecular actions of caffeine: focus on adenosine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anxiety Disorders; Behavior; Caffeine; Child; Cycli | 1984 |
Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor.
Topics: Animals; Brain; Caffeine; Carbolines; Flunitrazepam; Harmaline; Harmine; Indoles; Male; Rats; Rats, | 1982 |
Reduction in caffeine toxicity by acetaminophen.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acetaminophen; Acoustic Stimulation; Adenosine; Adult; A | 1982 |
Antagonism of caffeine-induced seizures in mice by Ro15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Caffeine; Diazepam; Female; Flumazenil; Mice; Receptors | 1984 |
[Interaction of kynurenine and diazepam].
Topics: Animals; Benzoates; Caffeine; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; D | 1984 |
Caffeine modification of kindled amygdaloid seizures.
Topics: Amygdala; Animals; Caffeine; Electric Stimulation; Kindling, Neurologic; Male; Rats; Rats, Inbred St | 1983 |
Adenosine modulation of amygdala kindling.
Topics: 2-Chloroadenosine; Adenosine; Aminophylline; Amygdala; Animals; Caffeine; Differential Threshold; Ki | 1984 |
Interstrain variation in acute toxic response to caffeine among inbred mice.
Topics: Animals; Behavior, Animal; Caffeine; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred BALB | 1984 |
The benzodiazepines and inosine antagonize caffeine-induced seizures.
Topics: Animals; Benzodiazepines; Caffeine; Inosine; Male; Mice; Mice, Inbred C3H; Receptors, Drug; Seizures | 1981 |
Phenylpropanolamine: a potentially hazardous drug.
Topics: Adolescent; Adult; Caffeine; Cardiovascular Diseases; Central Nervous System Diseases; Cerebral Hemo | 1982 |
Seizures associated with a new combination "pick-me-up" pill.
Topics: Adolescent; Caffeine; Drug Combinations; Ephedrine; Female; Humans; Phenylpropanolamine; Pregnancy; | 1982 |
Acute caffeine overdose in the neonate.
Topics: Caffeine; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Respiratory Insufficiency; Sei | 1980 |
Caffeine- and aminophylline-induced seizures.
Topics: Aminophylline; Animals; Arrhythmias, Cardiac; Caffeine; Cerebral Cortex; Electrocardiography; Electr | 1981 |
Neonatal caffeine exposure and seizure susceptibility in adult rats.
Topics: Animals; Animals, Newborn; Bicuculline; Brain; Caffeine; Female; Kainic Acid; Male; Pentylenetetrazo | 1995 |
Reduced proconvulsant activity of caffeine in rats after a series of electroconvulsive seizures.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Dose-Response Relationship, Drug; | 1995 |
Caffeine augmentation of electroconvulsive seizures.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; Epilepsy, | 1994 |
Caffeine attenuates CNS oxygen toxicity in rats.
Topics: Animals; Caffeine; Carbon Dioxide; Central Nervous System Diseases; Cerebrovascular Circulation; Dos | 1995 |
Neonatal caffeine exposure alters seizure susceptibility in rats in an age-related manner.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Convulsants; Disease Susceptibilit | 1995 |
Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation.
Topics: Animals; Anticonvulsants; Caffeine; Electroshock; Male; Mice; Phenobarbital; Seizures; Valproic Acid | 1996 |
Chronic caffeine and the anticonvulsant potency of antiepileptic drugs against maximal electroshock.
Topics: Animals; Anticonvulsants; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactio | 1996 |
Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding.
Topics: Animals; Autoradiography; Behavior, Animal; Bicuculline; Brain; Caffeine; Disease Susceptibility; Ma | 1996 |
Effect of intraperitoneal and intrahippocampal (CA1) 2-chloroadenosine in amygdaloid kindled rats.
Topics: 2-Chloroadenosine; Amygdala; Animals; Caffeine; Central Nervous System Stimulants; Electrophysiology | 1997 |
Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures.
Topics: 2-Chloroadenosine; Amygdala; Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; | 1997 |
Caffeine toxicity in a bodybuilder.
Topics: Adult; Caffeine; Doping in Sports; Emergency Service, Hospital; Humans; Male; Seizures; Substance-Re | 1998 |
Felbamate demonstrates low propensity for interaction with methylxanthines and Ca2+ channel modulators against experimental seizures in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Caffeine; Calcium Channels; Electric Stimulation; Felbamate | 1998 |
Genetic approaches to the neurobiology of electroconvulsive therapy.
Topics: Animals; Autoradiography; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Electroconvu | 1998 |
[Intractable vomiting, convulsions and megaloblastic anemia: anamnesis, key to diagnosis].
Topics: Adult; Anemia, Megaloblastic; Barbiturates; Caffeine; Diagnosis, Differential; Drug Combinations; Er | 1999 |
Proconvulsive effect of tea (Camellia sinensis) in mice.
Topics: Animals; Brain Chemistry; Caffeine; Convulsants; Electroshock; Female; gamma-Aminobutyric Acid; Male | 1999 |
Anticonvulsant action of 2-chloroadenosine injected focally into the perirhinal cortex in amygdaloid kindled rats.
Topics: 2-Chloroadenosine; Adenosine; Amygdala; Analysis of Variance; Animals; Anticonvulsants; Caffeine; Do | 1999 |
Relationship between large conductance calcium-activated potassium channel and bursting activity.
Topics: Action Potentials; Animals; Apamin; Caffeine; Calcium; Cells, Cultured; Cerebral Cortex; Epilepsy; I | 2000 |
Chemical kindling and seizure susceptibility in morphine dependent rats.
Topics: Animals; Caffeine; Convulsants; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Ago | 2000 |
Seizure activity and unresponsiveness after hydroxycut ingestion.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Citrates; Drug Combinations; Drugs, Chinese Herb | 2001 |
Psychostimulants and epilepsy.
Topics: Amphetamines; Caffeine; Cannabinoids; Central Nervous System Stimulants; Cocaine; Epilepsy; Hallucin | 2002 |
[Significance of chlorogenic acid in the centrally-stimulating effect of coffee].
Topics: Anesthesia; Animals; Caffeine; Central Nervous System; Chlorogenic Acid; Coffee; Drug Synergism; Ele | 1976 |
Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, | 1992 |
[Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice].
Topics: Animals; Baclofen; Benzodiazepines; Caffeine; Diazepam; Dizocilpine Maleate; Flumazenil; Male; Mice; | 1992 |
Excitatory amino acids and the actions of cocaine.
Topics: Animals; Caffeine; Cocaine; Dextromethorphan; Dizocilpine Maleate; Haloperidol; Male; Mice; Mice, In | 1992 |
Potentiation of cocaine and d-amphetamine toxicity with caffeine.
Topics: 2-Chloroadenosine; Animals; Caffeine; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; | 1992 |
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Femal | 1991 |
Beta-phenylethylamine (PEA): an endogenous anxiogen? Three series of experimental data.
Topics: Animals; Anti-Anxiety Agents; Arousal; Caffeine; Dose-Response Relationship, Drug; Male; Mice; Mice, | 1990 |
Adenosine involvement in postictal events in amygdala-kindled rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amygdala; Animals; Anticonvulsants; Caffeine; Electric | 1990 |
Presentation and management of an acute caffeine overdose.
Topics: Caffeine; Drug Overdose; Female; Humans; Infant; Respiratory Distress Syndrome; Seizures; Tachycardi | 1990 |
Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats.
Topics: Animals; Caffeine; Drug Interactions; Drug Tolerance; Kinetics; Male; Rats; Rats, Inbred Lew; Seizur | 1990 |
Caffeine-induced seizures: apparent proconvulsant action of N-ethyl carboxamidoadenosine (NECA).
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticonvulsants; Caffeine; Cerebral Ventricle | 1990 |
Phenylpropanolamine potentiates caffeine neurotoxicity in rats.
Topics: Animals; Appetite Depressants; Blood Proteins; Caffeine; Chromatography, High Pressure Liquid; Drug | 1989 |
Phencyclidine (PCP) reduces the intensity of caffeine-induced convulsions in rats.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; Female; Phencyclidine; Rats; Rats, Inbred Strai | 1989 |
Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC).
Topics: Animals; Caffeine; Convulsants; Diazepam; Dipyridamole; Male; Mice; Purinergic Antagonists; Random A | 1989 |
Different genes specify hyporesponsiveness to seizures induced by caffeine and the benzodiazepine inverse agonist, DMCM.
Topics: Animals; Caffeine; Carbolines; Crosses, Genetic; Disease Susceptibility; Genes; Genetics, Behavioral | 1987 |
Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Dextroamphetamine; Diazepam; El | 1985 |
Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Caffeine; Flumazenil; Flunitr | 1986 |
Postpartum seizure after epidural blood patch and intravenous caffeine sodium benzoate.
Topics: Adult; Analgesia, Epidural; Anesthesia, Obstetrical; Benzoates; Blood; Caffeine; Drug Combinations; | 1989 |
Changes in caffeine seizure threshold after electroconvulsive shock.
Topics: Animals; Caffeine; Electroshock; Male; Mice; Seizures; Time Factors | 1988 |
Caffeine as a potential risk factor for theophylline neurotoxicity.
Topics: Animals; Blood Proteins; Brain; Caffeine; Dialysis; Injections, Intravenous; Male; Nervous System Di | 1988 |
Behavioral effects of acute and chronic administration of caffeine in the rat.
Topics: Aggression; Animals; Behavior, Animal; Caffeine; Drug Administration Schedule; Exploratory Behavior; | 1988 |
Rapid development of functional tolerance to caffeine-induced seizures in rats.
Topics: Animals; Brain; Caffeine; Drug Tolerance; Kinetics; Male; Rats; Rats, Inbred Lew; Seizures; Theobrom | 1988 |
Anticonvulsant activity of carbamazepine and N6-L-phenylisopropyladenosine in rabbits. Relationship to adenosine receptors in central nervous system.
Topics: Adenosine; Animals; Anticonvulsants; Caffeine; Carbamazepine; Central Nervous System; Drug Interacti | 1988 |
Pharmacological manipulation of ECT-induced seizure duration.
Topics: Caffeine; Depressive Disorder; Differential Threshold; Electroconvulsive Therapy; Humans; Premedicat | 1986 |
Differential effects of caffeine, picrotoxin, and pentylenetetrazol on hippocampal afterdischarge activity and wet dog shakes.
Topics: Animals; Caffeine; Electroencephalography; Hippocampus; Male; Membrane Potentials; Pentylenetetrazol | 1987 |
Coincidence of seizure susceptibility to caffeine and to the benzodiazepine inverse agonist, DMCM, in SWR and CBA inbred mice.
Topics: Animals; Caffeine; Carbolines; Convulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbr | 1987 |
Augmentation of ECT seizures with caffeine.
Topics: Aged; Aged, 80 and over; Caffeine; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; M | 1987 |
Apnoea and seizures.
Topics: Apnea; Caffeine; Electroencephalography; Female; Humans; Infant; Male; Seizures | 1986 |
Adenosine antagonists. Lack of effect on the inhibition of kindled seizures in rats by carbamazepine.
Topics: Adenosine; Animals; Caffeine; Carbamazepine; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; | 1985 |
Caffeine distribution in acute toxic response among inbred mice.
Topics: Animals; Caffeine; Kinetics; Male; Mice; Mice, Inbred Strains; Seizures; Tissue Distribution | 1985 |
Reactivity of penicillin-induced epileptogenic foci to selective blockade of membrane sodium-potassium ATPase via ouabain.
Topics: Adenosine Triphosphatases; Animals; Biological Transport, Active; Caffeine; Cats; Cell Membrane; Ele | 1974 |
A myotoxin secreted by some piscivorous Conus species.
Topics: Animals; Anura; Ataxia; Bites and Stings; Blood Pressure; Caffeine; Cell Membrane Permeability; Chro | 1972 |
Potentiation of the anticonvulsant action of acetazolamide.
Topics: Acetazolamide; Amphetamine; Animals; Anticonvulsants; Caffeine; Cocaine; Desipramine; Drug Synergism | 1966 |
Flurothyl in mice: seizure, post-convulsive behavior, and interactions with psychotropic drugs.
Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Biperiden; Caffeine; Catalepsy; Central Nervous Sy | 1968 |
[Pharmacological studies on 2-methyl-4-amino-6-methoxy-s-triazine (CV399); with special reference to its central effects].
Topics: Amphetamine; Analgesics; Animals; Avoidance Learning; Behavior, Animal; Blood Pressure; Body Tempera | 1970 |
Effects of drugs acting alone and in combination on the motor activity of intact mice.
Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central | 1970 |
Effects of general stimulant drugs on the electrical responses of isolated slabs of cat's cerebral cortex.
Topics: Action Potentials; Animals; Bemegride; Caffeine; Cats; Central Nervous System Stimulants; Cerebral C | 1970 |
[Introduction of mass psychology in animals to pharmacology. 6. Mutural relation in simultaneity convulsion and non-convulsin in E1-mice].
Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Camphor; Central Nervous Sy | 1970 |
Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine.
Topics: Amides; Amino Acids; Animals; Bemegride; Brain; Brain Chemistry; Caffeine; Carbon Isotopes; Central | 1971 |
Increase in the content of adenosine 3',5'-monophosphate in mouse forebrain during seizures and prevention of the increase by methylxanthines.
Topics: Adenine Nucleotides; Caffeine; Central Nervous System Stimulants; Cyclic AMP; Electroshock; Ethers; | 1971 |
Experimental study of the effect of lithium, haloperidol, caffeine and theophylline on convulsive seizure reactions.
Topics: Animals; Caffeine; Drug Synergism; Haloperidol; Lithium; Male; Rats; Seizures; Theophylline | 1974 |
Experimental studies on the effective procedure to inhibit the development of tolerance to and dependence on morphine.
Topics: Analgesia; Animals; Caffeine; Drug Synergism; Drug Tolerance; Haplorhini; Humans; Injections, Subcut | 1970 |
Further observations on the role of -aminobutyric acid in insulin-induced hypoglycaemic convulsions.
Topics: Acetates; Amino Acids; Aminobutyrates; Animals; Anticonvulsants; Blood Glucose; Brain; Brain Chemist | 1972 |
[Comparative studieson the central stimulating effects of caffeie and chlorogenic acid in white mice].
Topics: Animals; Caffeine; Chlorogenic Acid; Drug Antagonism; Hexobarbital; Male; Mice; Movement; Oxygen Con | 1971 |
Teratogenicity of caffeine in mice related to its mode of administration.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cleft Palate; Clubfoot; Dyspnea; Fingers; Gestationa | 1969 |
Physiological and drug-induced changes in the glycogen content of mouse brain.
Topics: Amphetamine; Animals; Bemegride; Body Temperature; Brain Chemistry; Caffeine; Catecholamines; Circad | 1970 |
On certain central neurotropic effects of lavender essential oil.
Topics: Amphetamine; Animals; Anticonvulsants; Caffeine; Oils, Volatile; Rats; Seizures | 1970 |
[Symposium--drug action and animal behavior. 5. Psychopharmacological studies on mutural relations in induced convulsion of E1-mice].
Topics: Amphetamine; Animals; Behavior, Animal; Caffeine; Group Processes; Mice; Rodent Diseases; Seizures | 1970 |
Neuropharmacological properties of Su17595A a chlorpromazine-like central nervous system depressant.
Topics: Animals; Blood Pressure; Brain Stem; Caffeine; Cats; Chlordiazepoxide; Chlorpromazine; Cocaine; Depr | 1971 |
Influence of alkylamides of glutamic acid and related compounds on the central nervous system. II. Syntheses of amides of gutamic acid and related compounds, and their effects on the central nervous system.
Topics: Amides; Animals; Anticonvulsants; Caffeine; Central Nervous System; Cerebral Cortex; Glutamates; In | 1971 |
[Kulenkampf-Tarnow syndrome, problems of its pathogenesis and treatment].
Topics: Adolescent; Adult; Atropine; Brain Stem; Caffeine; Chlorpromazine; Ephedrine; Humans; Male; Masticat | 1968 |