caffeine and Recrudescence

caffeine has been researched along with Recrudescence in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (21.43)	18.7374
1990's	8 (19.05)	18.2507
2000's	13 (30.95)	29.6817
2010's	10 (23.81)	24.3611
2020's	2 (4.76)	2.80

Authors

Authors	Studies
Aylward, P; Bhatt, DL; Bonaca, MP; Dellborg, M; Furtado, RHM; Goto, S; Gurmu, Y; Isaza, D; Johanson, P; Kamensky, G; Magnani, G; Nicolau, JC; Steg, PG; Storey, RF; Venkateswaran, RV	1
Han, MJ; Hwang, JH; Kim, SH; Shin, JH	1
López-García, E; Rodríguez-Artalejo, F	1
Chen, SL; Ennis, SS; Guo, H; Raman, L; Tambyah, PA; Tiong, HY	1
Peerapen, P; Thongboonkerd, V	1
Carroll, ME; Claxton, AB; Regier, PS; Zlebnik, NE	1
Henesch, JA; Hoffman, RS; Laskowski, LK; Nelson, LS; Smith, SW	1
Baños, I; Barajas, A; Del Cacho, N; Dolz, M; Huerta-Ramos, E; Núñez, C; Ochoa, S; Sánchez, B; Usall, J	1
Dhillon, R; Tibrewal, P	1
De Paoli, AG; Henderson-Smart, DJ	1
Menkes, DB	1
Hawryluck, LA; Kraeva, N; Riazi, S; Russell, T; Steel, AC	1
Aloisio, A; Del Bianco, P; Di Monda, V; Fonzari, M; Grazioli, I; Nicolodi, M; Sicuteri, F; Uslenghi, C; Vecchiet, L	1
Henry, S; Noorbakhsh, F; Power, C; Schnermann, J; Tsutsui, S; Warren, K; Winston, BW; Yong, VW	1
De La Corte, FD; Dranchak, PK; Ekenstedt, K; Gallant, EM; MacLeay, JM; McKenzie, EC; Mickelson, JR; Onan, GW; Valberg, SJ	1
Colton, P; Poynter, B; Sacevich, T; Schreiber, M; Staab, R; Sutandar-Pinnock, K; Woodside, DB	1
Cnattingius, S; George, L; Granath, F; Johansson, AL; Olander, B	1
Hopkins, M; Malik, SN; Silberstein, SD; Young, WB	1
Cerbo, R; Del Bene, E; Ferrari, A; Genco, S; Grazioli, I; Martelletti, P; Nappi, G; Pinessi, L; Sandrini, G; Sarchielli, P; Tamburro, P; Uslenghi, C; Zanchin, G	1
Blin, MC; Couchard, M; De Gamarra, E; Dreyfus-Brisac, C; Flouvat, B; Moriette, G; Murat, I; Relier, JP	1
Astasio-Arbiza, P; de Juanes-Pardo, JR; Domínguez-Rojas, V; Gordillo-Florencio, E; Ortega-Molina, P	1
Beale, MD; Kellner, CH; Pritchett, JT	1
Anaya Ordóñez, S; Matas Hoces, A	1
Barnhart, WJ; Lehman, DA; Nestler, EJ; Self, DW	1
Maizels, M	1
Balog, EM; Gallant, EM; Lentz, LR; Mickelson, JR; Valberg, SJ	1
Gallant, EM; Mickelson, JR; Valberg, SJ; Ward, TL	1
Tobias, JD	1
Ajioka, RS; Bergonia, HA; Bulaj, ZJ; Edwards, CQ; Franklin, MR; Griffen, LM; Guinee, DJ; Kushner, JP; Miller, KL; Phillips, JD	1
Freeman, D; Randall, DB	1
Bache, M; Bartel, F; Dunst, J; Meye, A; Pigorsch, S; Rath, FW; Schmidt, H; Taubert, H; Würl, P	1
Mauskop, A	1
Rudas, N; Tondo, L	1
Bairam, A; Vert, P	1
La Cascia, C; Mascarella, A; Migneco, G; Navetta, A; Tripi, S	1
Bucher, HU; Duc, G	1
Holstege, A	1
Birkett, DJ; Cameron-Traub, E; James, JE; Lelo, A; Miners, JO; Paull, I	1
Dzegede, S; Finlayson, B; Scheaffer, RL; Shuster, J; Sierakowski, R; Zoltek, J	1
Friedman, AP	1

Reviews

4 review(s) available for caffeine and Recrudescence

Article	Year
Coffee Consumption and Cardiovascular Disease: A Condensed Review of Epidemiological Evidence and Mechanisms. Journal of agricultural and food chemistry, 2018, May-30, Volume: 66, Issue:21 Topics: Aged; Blood Pressure; Caffeine; Cardiovascular Diseases; Coffee; Female; Humans; Hypertension; Male; Middle Aged; Recurrence; Risk Factors; Smoking	2018
Caffeine in Kidney Stone Disease: Risk or Benefit? Advances in nutrition (Bethesda, Md.), 2018, 07-01, Volume: 9, Issue:4 Topics: Beverages; Caffeine; Carbonated Beverages; Coffee; Diet; Diuretics; Dose-Response Relationship, Drug; Energy Drinks; Humans; Kidney; Kidney Calculi; Prospective Studies; Recurrence; Retrospective Studies; Risk Factors; Tea	2018
Prophylactic methylxanthine for prevention of apnoea in preterm infants. The Cochrane database of systematic reviews, 2010, Dec-08, Issue:12 Topics: Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Humans; Hypoxia; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Randomized Controlled Trials as Topic; Recurrence; Theophylline; Xanthines	2010
[Effects of nicotine, alcohol and caffeine on the incidence, healing and recurrence rate of peptic ulcer]. Zeitschrift fur Gastroenterologie, 1987, Volume: 25 Suppl 3 Topics: Caffeine; Ethanol; Humans; Nicotine; Peptic Ulcer; Recurrence; Smoking; Wound Healing	1987

Trials

7 trial(s) available for caffeine and Recrudescence

Article	Year
Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial. Journal of the American Heart Association, 2020, 05-18, Volume: 9, Issue:10 Topics: Aged; Aspirin; Beverages; Caffeine; Double-Blind Method; Dual Anti-Platelet Therapy; Dyspnea; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Risk Assessment; Risk Factors; Secondary Prevention; Ticagrelor; Time Factors; Treatment Outcome	2020
Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine versus sumatriptan in acute treatment of multiple migraine attacks: a multicenter, randomized, crossover trial. Headache, 2003, Volume: 43, Issue:8 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Drug Combinations; Female; Humans; Indomethacin; Male; Migraine Disorders; Prochlorperazine; Recurrence; Research Design; Serotonin Receptor Agonists; Sumatriptan; Suppositories; Treatment Outcome	2003
Efficacy of dosing and re-dosing of two oral fixed combinations of indomethacin, prochlorperazine and caffeine compared with oral sumatriptan in the acute treatment of multiple migraine attacks: a double-blind, double-dummy, randomised, parallel group, mu International journal of clinical practice, 2007, Volume: 61, Issue:8 Topics: Administration, Oral; Adolescent; Adult; Analgesics; Caffeine; Double-Blind Method; Drug Combinations; Female; Humans; Indomethacin; Male; Middle Aged; Migraine Disorders; Prochlorperazine; Recurrence; Sumatriptan; Treatment Outcome	2007
The efficacy of caffeine in the treatment of recurrent idiopathic apnea in premature infants. The Journal of pediatrics, 1981, Volume: 99, Issue:6 Topics: Apnea; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Prospective Studies; Recurrence	1981
[Sumatriptan in the treatment of acute migraine: its role in primary health care]. Atencion primaria, 1994, Apr-30, Volume: 13, Issue:7 Topics: Acute Disease; Administration, Oral; Algorithms; Aspirin; Caffeine; Double-Blind Method; Drug Therapy, Combination; Ergotamine; Humans; Injections, Subcutaneous; Metoclopramide; Migraine Disorders; Recurrence; Sumatriptan	1994
A randomized, double-blind comparison of sumatriptan and Cafergot in the acute treatment of migraine. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group. European neurology, 1991, Volume: 31, Issue:5 Topics: Administration, Oral; Adult; Aged; Caffeine; Double-Blind Method; Drug Combinations; Electrocardiography; Ergotamine; Female; Humans; Indoles; Male; Middle Aged; Migraine Disorders; Nausea; Recurrence; Sulfonamides; Sumatriptan; Vasoconstrictor Agents; Vomiting	1991
Does caffeine prevent hypoxaemic episodes in premature infants? A randomized controlled trial. European journal of pediatrics, 1988, Volume: 147, Issue:3 Topics: Blood Gas Monitoring, Transcutaneous; Bradycardia; Caffeine; Citrates; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hypoxia; Infant, Newborn; Infant, Premature, Diseases; Male; Random Allocation; Recurrence	1988

Other Studies

31 other study(ies) available for caffeine and Recrudescence

Article	Year
Caffeine-induced hypokalemia: a case report. BMC nephrology, 2021, 07-09, Volume: 22, Issue:1 Topics: Adult; Caffeine; Coffee; Diet Therapy; Diuretics; Drinking Behavior; Fluid Therapy; Humans; Hypokalemia; Male; Muscle Weakness; Osmolar Concentration; Paraplegia; Potassium; Recurrence; Treatment Outcome; Urinalysis	2021
Premenopausal women with recurrent urinary tract infections have lower quality of life. International journal of urology : official journal of the Japanese Urological Association, 2018, Volume: 25, Issue:7 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Caffeine; Coffee; Comorbidity; Constipation; Feeding Behavior; Female; Humans; Premenopause; Quality of Life; Recurrence; Risk Factors; Singapore; Surveys and Questionnaires; Urinary Tract Infections	2018
Cocaine-, caffeine-, and stress-evoked cocaine reinstatement in high vs. low impulsive rats: treatment with allopregnanolone. Drug and alcohol dependence, 2014, Oct-01, Volume: 143 Topics: Animals; Behavior, Addictive; Caffeine; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Delay Discounting; Extinction, Psychological; Female; Impulsive Behavior; Pregnanolone; Rats; Rats, Inbred Strains; Recurrence; Self Administration; Yohimbine	2014
Start me up! Recurrent ventricular tachydysrhythmias following intentional concentrated caffeine ingestion. Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:8 Topics: Adrenergic beta-Antagonists; Caffeine; Dietary Supplements; Electric Countershock; Electrocardiography; Female; Hemodynamics; Humans; Poisoning; Recovery of Function; Recurrence; Renal Dialysis; Severity of Illness Index; Suicide, Attempted; Tachycardia, Ventricular; Treatment Outcome; Young Adult	2015
Differential effects of sex on substance use between first episode psychosis patients and healthy people. Comprehensive psychiatry, 2016, Volume: 69 Topics: Adolescent; Adult; Alcohol Drinking; Caffeine; Cannabis; Comorbidity; Female; Humans; Illicit Drugs; Male; Marijuana Abuse; Prevalence; Psychoses, Substance-Induced; Psychotic Disorders; Recurrence; Reference Values; Risk Factors; Sex Factors; Smoking; Spain; Substance-Related Disorders; Young Adult	2016
Caffeine induced psychotic exacerbation. The Australian and New Zealand journal of psychiatry, 2011, Volume: 45, Issue:2 Topics: Caffeine; Humans; Male; Middle Aged; Recurrence; Schizophrenia	2011
Transient psychotic relapse temporally related to ingestion of an "energy drink". The Medical journal of Australia, 2011, Feb-21, Volume: 194, Issue:4 Topics: Adult; Beverages; Caffeine; Central Nervous System Stimulants; Humans; Male; Psychoses, Substance-Induced; Recurrence	2011
Ecstacy-induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene. Anaesthesia, 2012, Volume: 67, Issue:9 Topics: Anesthetics, Inhalation; Antipsychotic Agents; Body Temperature; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Creatine Kinase; Dantrolene; Disseminated Intravascular Coagulation; Female; Genetic Variation; Hallucinogens; Haloperidol; Halothane; Humans; Multiple Organ Failure; N-Methyl-3,4-methylenedioxyamphetamine; Neuroleptic Malignant Syndrome; Recurrence; Rhabdomyolysis; Ryanodine Receptor Calcium Release Channel; Spectrum Analysis; Young Adult	2012
A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Feb-11, Volume: 24, Issue:6 Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Caffeine; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Inflammation; Inflammation Mediators; Interleukin-1; Macrophages; Matrix Metalloproteinase 12; Metalloendopeptidases; Mice; Mice, Knockout; Microglia; Multiple Sclerosis; Myelin Sheath; Phenotype; Receptor, Adenosine A1; Recurrence; RNA, Messenger; Severity of Illness Index; Spinal Cord; Up-Regulation	2004
Inheritance of recurrent exertional rhabdomyolysis in thoroughbreds. Journal of the American Veterinary Medical Association, 2005, Sep-01, Volume: 227, Issue:5 Topics: Anesthetics, Inhalation; Animals; Biopsy; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Female; Genes, Dominant; Halothane; Horse Diseases; Horses; Male; Muscle Contraction; Muscle, Skeletal; Pedigree; Physical Conditioning, Animal; Recurrence; Rhabdomyolysis	2005
Weight restoration in a patient with anorexia nervosa on dialysis. The International journal of eating disorders, 2005, Volume: 38, Issue:4 Topics: Adult; Anorexia Nervosa; Aspirin; Barbiturates; Body Mass Index; Body Weight; Caffeine; Combined Modality Therapy; Comorbidity; Cooperative Behavior; Creatinine; Drug Combinations; Female; Heart Failure; Humans; Kidney Failure, Chronic; Patient Care Team; Psychotherapy, Group; Recurrence; Renal Dialysis; Substance-Related Disorders; Treatment Outcome; Treatment Refusal; Water-Electrolyte Imbalance	2005
Risks of repeated miscarriage. Paediatric and perinatal epidemiology, 2006, Volume: 20, Issue:2 Topics: Abortion, Spontaneous; Adult; Caffeine; Case-Control Studies; Cotinine; Dietary Supplements; Female; Fertilization; Folic Acid; Humans; Leiomyoma; Maternal Age; Pregnancy; Recurrence; Risk Factors; Smoking; Sweden; Uterine Neoplasms	2006
Acute migraine treatment: patterns of use and satisfaction in a clinical population. Headache, 2006, Volume: 46, Issue:5 Topics: Acetaminophen; Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Drug Combinations; Ergotamine; Female; Health Surveys; Humans; Male; Middle Aged; Migraine Disorders; Narcotics; Nonprescription Drugs; Patient Satisfaction; Recurrence; Serotonin Receptor Agonists; Surveys and Questionnaires	2006
Analgesic abuse and the kidney. Kidney international, 1980, Volume: 17, Issue:2 Topics: Aged; Analgesics; Aspirin; Caffeine; Codeine; Drug Combinations; Humans; Kidney; Kidney Diseases; Kidney Failure, Chronic; Kidney Transplantation; Male; Nephrectomy; Nephritis, Interstitial; Oxycodone; Phenacetin; Pseudomonas Infections; Pyelonephritis; Recurrence; Substance-Related Disorders; Transplantation, Homologous	1980
Spontaneous abortion in a hospital population: are tobacco and coffee intake risk factors? European journal of epidemiology, 1994, Volume: 10, Issue:6 Topics: Abortion, Spontaneous; Adult; Age Factors; Alcohol Drinking; Caffeine; Case-Control Studies; Coffee; Cohort Studies; Confounding Factors, Epidemiologic; Dose-Response Relationship, Drug; Female; Humans; Logistic Models; Marital Status; Menarche; Odds Ratio; Pregnancy; Recurrence; Reproductive History; Retrospective Studies; Risk Factors; Smoking	1994
Supraventricular tachycardia in a patient receiving ECT, clozapine, and caffeine. Convulsive therapy, 1994, Volume: 10, Issue:3 Topics: Affective Disorders, Psychotic; Aged; Caffeine; Clozapine; Combined Modality Therapy; Depressive Disorder; Drug Therapy, Combination; Electrocardiography; Electroconvulsive Therapy; Female; Humans; Recurrence; Tachycardia, Supraventricular	1994
Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists. Science (New York, N.Y.), 1996, Mar-15, Volume: 271, Issue:5255 Topics: Animals; Behavior, Addictive; Behavior, Animal; Benzazepines; Caffeine; Cocaine; Dopamine Agonists; Ergolines; Male; Motor Activity; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Recurrence; Reinforcement, Psychology; Substance-Related Disorders; Tetrahydronaphthalenes	1996
Limitations of acetaminophen, aspirin, and caffeine in alleviating migraine. Archives of neurology, 1998, Volume: 55, Issue:12 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Drug Therapy, Combination; Humans; Migraine Disorders; Recurrence; Reproducibility of Results; Severity of Illness Index; Treatment Outcome	1998
Abnormal regulation of muscle contraction in horses with recurrent exertional rhabdomyolysis. American journal of veterinary research, 1999, Volume: 60, Issue:8 Topics: Anesthetics, Inhalation; Animals; Biopsy; Caffeine; Central Nervous System Stimulants; Female; Halothane; Horse Diseases; Horses; Male; Malignant Hyperthermia; Membrane Potentials; Muscle Contraction; Muscle, Skeletal; Pedigree; Physical Exertion; Potassium; Recurrence; Regression Analysis; Rhabdomyolysis	1999
Calcium regulation by skeletal muscle membranes of horses with recurrent exertional rhabdomyolysis. American journal of veterinary research, 2000, Volume: 61, Issue:3 Topics: Animals; Biopsy; Caffeine; Calcium; Calcium-Transporting ATPases; Dose-Response Relationship, Drug; Female; Horse Diseases; Horses; Male; Muscle, Skeletal; Physical Exertion; Recurrence; Rhabdomyolysis; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Scintillation Counting	2000
Caffeine in the treatment of apnea associated with respiratory syncytial virus infection in neonates and infants. Southern medical journal, 2000, Volume: 93, Issue:3 Topics: Apnea; Caffeine; Central Nervous System Stimulants; Critical Care; Data Interpretation, Statistical; Follow-Up Studies; Humans; Infant; Infant, Newborn; Injections, Intravenous; Recurrence; Respiratory Syncytial Virus Infections; Respiratory Tract Infections; Retrospective Studies; Time Factors	2000
Transdermal estrogen replacement therapy in postmenopausal women previously treated for porphyria cutanea tarda. The Journal of laboratory and clinical medicine, 2000, Volume: 136, Issue:6 Topics: Administration, Cutaneous; Adult; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Estrogen Replacement Therapy; Female; Humans; Liver; Menopause; Middle Aged; Phlebotomy; Porphyria Cutanea Tarda; Recurrence; Risk Factors; Safety	2000
Stress fracture of the foot secondary to osteoporosis: an atypical presentation. Journal of the American Podiatric Medical Association, 2001, Volume: 91, Issue:2 Topics: Adult; Caffeine; Female; Foot Bones; Fractures, Stress; Humans; Osteoporosis; Recurrence	2001
Loss of G2/M arrest correlates with radiosensitization in two human sarcoma cell lines with mutant p53. International journal of cancer, 2001, Apr-20, Volume: 96, Issue:2 Topics: Adenocarcinoma; Alleles; Apoptosis; Blotting, Western; Caffeine; Cell Survival; Combined Modality Therapy; Comet Assay; Disease-Free Survival; DNA Damage; Dose-Response Relationship, Radiation; G2 Phase; Genes, p53; Humans; Inhibitory Concentration 50; Male; Mitosis; Mutation; Nuclear Proteins; Phosphodiesterase Inhibitors; Prostate-Specific Antigen; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Radiation Tolerance; Radiotherapy; Recurrence; Risk Factors; Salvage Therapy; Sarcoma; Sensitivity and Specificity; Time Factors; Tumor Cells, Cultured	2001
Clinical features of withdrawal headache following overuse of triptans and other headache drugs. Neurology, 2002, May-14, Volume: 58, Issue:9 Topics: Analgesics; Caffeine; Causality; Codeine; Drug Overdose; Headache; Headache Disorders; Humans; Prospective Studies; Recurrence; Serotonin Receptor Agonists; Substance Withdrawal Syndrome	2002
The course of a seasonal bipolar disorder influenced by caffeine. Journal of affective disorders, 1991, Volume: 22, Issue:4 Topics: Bipolar Disorder; Caffeine; Chlorpromazine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Haloperidol; Humans; Lithium; Middle Aged; Recurrence; Seasons	1991
Low-dose doxapram for apnoea of prematurity. Lancet (London, England), 1986, Apr-05, Volume: 1, Issue:8484 Topics: Apnea; Caffeine; Doxapram; Drug Therapy, Combination; Humans; Infant, Newborn; Infant, Premature, Diseases; Pilot Projects; Recurrence	1986
[Cytolytic episodes during cirrhosis]. La Clinica terapeutica, 1986, Jul-31, Volume: 118, Issue:2 Topics: Antipyrine; Anxiety Disorders; Barbiturates; Caffeine; Cholestasis; Drug Therapy, Combination; Female; Haloperidol; Humans; Liver Cirrhosis; Maprotiline; Middle Aged; Recurrence; Temazepam; Time Factors	1986
Biochemical validation of self-reported caffeine consumption during caffeine fading. Journal of behavioral medicine, 1988, Volume: 11, Issue:1 Topics: Adult; Caffeine; Coffee; Female; Humans; Male; Middle Aged; Recurrence; Self Disclosure; Substance-Related Disorders; Tea; Xanthines	1988
Primary liquid intake and urinary stone disease. Journal of chronic diseases, 1985, Volume: 38, Issue:11 Topics: Adolescent; Adult; Animals; Beer; Beverages; Caffeine; Cattle; Drinking; Epidemiologic Methods; Hernia, Inguinal; Humans; Male; Middle Aged; Milk; Recurrence; Risk; United States; Ureteral Calculi	1985
Migraine headaches. JAMA, 1972, Dec-11, Volume: 222, Issue:11 Topics: Caffeine; Contraceptives, Oral; Cyproheptadine; Diagnosis, Differential; Diuretics; Drug Combinations; Ergotamine; Humans; Methysergide; Migraine Disorders; Monoamine Oxidase Inhibitors; Personality; Propranolol; Recurrence; Stress, Physiological; Substance Withdrawal Syndrome; Tranquilizing Agents	1972