caffeine has been researched along with Pancreatic Neoplasms in 25 studies
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a phase I-II study, 28 patients with advanced pancreatic adenocarcinoma were treated with cisplatin, high-dose cytarabine (ARA-C), and caffeine." | 5.06 | Advanced pancreatic cancer: a phase I-II trial of cisplatin, high-dose cytarabine, and caffeine. ( Botet, J; Dougherty, JB; Kelsen, D; Kemeny, N; Magill, G; Niedzwiecki, D, 1989) |
| " We aimed to investigate the effects of caffeine and its analog CGS 15943 on hepatocellular carcinoma (HCC) and pancreatic cancer adenocarcinoma (PDAC)." | 3.80 | Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. ( Edling, CE; Falasca, M; Ghonaim, R; Maffucci, T; Selvaggi, F, 2014) |
| "In locally advanced pancreatic cancer, the utilization of chemotherapy and radiotherapy is increasing, although in view of the reported long-term results of several contemporary trials, further improvements are certainly needed." | 2.71 | Chemoradiotherapy in the treatment of regional pancreatic carcinoma: a phase II study. ( Adsay, V; Al-Sukhun, S; Ben-Josef, E; Forman, JD; Heilbrun, LK; Levin, K; Philip, PA; Shields, AF; Soulen, R; Vaitkevicius, VK; Weaver, D; Zalupski, MM, 2003) |
| "Caffeine is a methylxanthine whose primary biologic effect is antagonism of the adenosine receptor." | 2.38 | Wake up and smell the coffee. Caffeine, coffee, and the medical consequences. ( Chou, T, 1992) |
| "Pancreatic cancer is the fifth leading cause of cancer related deaths in the United States." | 1.30 | Molecular effects of taxol and caffeine on pancreatic cancer cells. ( Al-Katib, AA; Aranha, O; Gururajanna, B; Li, YW; Sarkar, FH; Vaitkevicius, VK, 1999) |
| "Post-treatment with caffeine from 0 to 132 h had a dose-dependent biphasic effect on pancreatic tumorigenesis: post-treatment with the m." | 1.27 | Effects of caffeine on pancreatic tumorigenesis by 4-hydroxyaminoquinoline 1-oxide in partially pancreatectomized rats. ( Denda, A; Emi, Y; Konishi, Y; Mikami, S; Murata, Y; Ohara, T; Sunagawa, M; Takahashi, S; Yokose, Y, 1983) |
| "The relationship between pancreatic cancer and coffee, decaffeinated coffee and tea drinking habits was evaluated using data from a hospital-based case-control study conducted in Northern Italy on 150 histologically confirmed cases and 605 controls with acute, non-neoplastic, other than digestive tract diseases unrelated to coffee consumption or to any of the known or potential risk factors for cancer of the pancreas." | 1.27 | Coffee consumption and risk of pancreatic cancer. ( Decarli, A; Franceschi, S; La Vecchia, C; Liati, P; Negri, E, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (48.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Edling, CE | 1 |
| Selvaggi, F | 1 |
| Ghonaim, R | 1 |
| Maffucci, T | 1 |
| Falasca, M | 1 |
| Kadlubar, S | 1 |
| Anderson, JP | 1 |
| Sweeney, C | 1 |
| Gross, MD | 1 |
| Lang, NP | 1 |
| Kadlubar, FF | 1 |
| Anderson, KE | 1 |
| Sun, D | 2 |
| Urrabaz, R | 2 |
| Buzello, C | 2 |
| Nguyen, M | 2 |
| Al-Sukhun, S | 1 |
| Zalupski, MM | 2 |
| Ben-Josef, E | 1 |
| Vaitkevicius, VK | 3 |
| Philip, PA | 1 |
| Soulen, R | 1 |
| Weaver, D | 1 |
| Adsay, V | 1 |
| Heilbrun, LK | 1 |
| Levin, K | 1 |
| Forman, JD | 1 |
| Shields, AF | 2 |
| Ernster, VL | 1 |
| Denda, A | 1 |
| Yokose, Y | 1 |
| Emi, Y | 1 |
| Murata, Y | 1 |
| Ohara, T | 1 |
| Sunagawa, M | 1 |
| Mikami, S | 1 |
| Takahashi, S | 1 |
| Konishi, Y | 1 |
| Horwitz, DL | 1 |
| Nehlig, A | 1 |
| Debry, G | 1 |
| Gururajanna, B | 1 |
| Al-Katib, AA | 1 |
| Li, YW | 1 |
| Aranha, O | 1 |
| Sarkar, FH | 1 |
| Ahmed, S | 1 |
| Du, W | 1 |
| Arlauskas, P | 1 |
| Gordon, C | 1 |
| Kellogg, C | 1 |
| Kang, G | 1 |
| Chepurny, OG | 1 |
| Holz, GG | 1 |
| Nishikawa, A | 1 |
| Furukawa, F | 1 |
| Imazawa, T | 1 |
| Yoshimura, H | 1 |
| Mitsumori, K | 1 |
| Takahashi, M | 1 |
| Chou, T | 1 |
| Poston, GJ | 1 |
| Williamson, RC | 1 |
| Kelsen, D | 2 |
| Hudis, C | 1 |
| Niedzwiecki, D | 2 |
| Dougherty, J | 1 |
| Casper, E | 1 |
| Botet, J | 2 |
| Vinciguerra, V | 1 |
| Rosenbluth, R | 1 |
| Dougherty, JB | 1 |
| Kemeny, N | 1 |
| Magill, G | 1 |
| Coffey, RJ | 1 |
| Go, VL | 1 |
| Zinsmeister, AR | 1 |
| DiMagno, EP | 1 |
| La Vecchia, C | 1 |
| Liati, P | 1 |
| Decarli, A | 1 |
| Negri, E | 1 |
| Franceschi, S | 1 |
| Wynder, EL | 1 |
| Dieck, GS | 1 |
| Hall, NE | 1 |
| Norell, SE | 1 |
| Ahlbom, A | 1 |
| Erwald, R | 1 |
| Jacobson, G | 1 |
| Lindberg-Navier, I | 1 |
| Olin, R | 1 |
| Törnberg, B | 1 |
| Wiechel, KL | 1 |
| Pozniak, PC | 1 |
| Kyriazis, AP | 1 |
| Kyriazis, AA | 1 |
| Yagoda, A | 1 |
5 reviews available for caffeine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Epidemiologic studies of caffeine and human health.
Topics: Adult; Age Factors; Aged; Blood Pressure; Caffeine; Cardiovascular Diseases; Epidemiologic Methods; | 1984 |
Coffee and cancer: a review of human and animal data.
Topics: Animals; Caffeine; Coffee; Dose-Response Relationship, Drug; Gastrointestinal Neoplasms; Humans; Inc | 1996 |
Wake up and smell the coffee. Caffeine, coffee, and the medical consequences.
Topics: Arrhythmias, Cardiac; Beverages; Caffeine; Catecholamines; Coffee; Coronary Disease; Humans; Pancrea | 1992 |
Causes, diagnosis, and management of exocrine pancreatic cancer.
Topics: 2-Naphthylamine; Angiography; Benzidines; Caffeine; Cholangiopancreatography, Endoscopic Retrograde; | 1990 |
The carcinogenicity of caffeine and coffee: a review.
Topics: Breast Neoplasms; Caffeine; Coffee; Epidemiologic Methods; Female; Humans; Intestinal Neoplasms; Kin | 1985 |
4 trials available for caffeine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Chemoradiotherapy in the treatment of regional pancreatic carcinoma: a phase II study.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Caff | 2003 |
Cisplatin, cytarabine, caffeine, and continuously infused 5-fluorouracil (PACE) in the treatment of advanced pancreatic carcinoma: a phase II study.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic | 2000 |
A phase III comparison trial of streptozotocin, mitomycin, and 5-fluorouracil with cisplatin, cytosine arabinoside, and caffeine in patients with advanced pancreatic carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Caffeine; Carboplatin; | 1991 |
Advanced pancreatic cancer: a phase I-II trial of cisplatin, high-dose cytarabine, and caffeine.
Topics: Acute Disease; Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Caffeine; Cisplatin; | 1989 |
16 other studies available for caffeine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway.
Topics: Antineoplastic Agents; Apoptosis; Caffeine; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; | 2014 |
Phenotypic CYP2A6 variation and the risk of pancreatic cancer.
Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Caffeine; Carcinogens; Case-Control S | 2009 |
Induction of DNA ligase I by 1-beta-D-arabinosylcytosine and aphidicolin in MiaPaCa human pancreatic cancer cells.
Topics: Antimetabolites, Antineoplastic; Aphidicolin; Caffeine; Cell Count; Cell Division; Cell Line; Cell S | 2002 |
Effects of cisplatin on expression of DNA ligases in MiaPaCa human pancreatic cancer cells.
Topics: Antineoplastic Agents; Caffeine; Cell Cycle; Cisplatin; DNA Ligase ATP; DNA Ligases; Humans; Pancrea | 2002 |
Effects of caffeine on pancreatic tumorigenesis by 4-hydroxyaminoquinoline 1-oxide in partially pancreatectomized rats.
Topics: 4-Hydroxyaminoquinoline-1-oxide; Aminoquinolines; Animals; Body Weight; Caffeine; DNA; DNA Repair; M | 1983 |
Third international caffeine workshop.
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Bone Development; Caffeine; Dose-Response Relatio | 1981 |
Coffee and caffeine.
Topics: Animals; Caffeine; Coffee; Humans; Pancreatic Neoplasms; Risk | 1981 |
Molecular effects of taxol and caffeine on pancreatic cancer cells.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Caffei | 1999 |
cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells.
Topics: Animals; Caffeine; Calcium; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cycl | 2001 |
Effects of caffeine, nicotine, ethanol and sodium selenite on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine.
Topics: Animals; Body Weight; Caffeine; Carcinogens; Cricetinae; Ethanol; Female; Nicotine; Nitrosamines; Pa | 1992 |
The acute effects of coffee and caffeine on human interdigestive exocrine pancreatic secretion.
Topics: Adenocarcinoma; Adult; Caffeine; Coffee; Fasting; Female; Gastric Acid; Gastrins; Humans; Male; Midd | 1986 |
Coffee consumption and risk of pancreatic cancer.
Topics: Adult; Aged; Caffeine; Coffee; Female; Humans; Male; Middle Aged; Pancreatic Neoplasms; Risk; Smokin | 1987 |
Case-control study of decaffeinated coffee consumption and pancreatic cancer.
Topics: Adult; Aged; Caffeine; Coffee; Female; Humans; Male; Middle Aged; Pancreatic Neoplasms; Sex Factors; | 1986 |
Diet and pancreatic cancer: a case-control study.
Topics: Adult; Aged; Caffeine; Diet; Epidemiologic Methods; Ethanol; Female; Humans; Male; Middle Aged; Panc | 1986 |
Caffeine.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fibrocystic Breast Disease; Half-Life; Heart | 1985 |
Enhanced therapeutic effect of cis-diamminedichloroplatinum(II) against nude mouse grown human pancreatic adenocarcinoma when combined with 1-beta-D-arabinofuranosylcytosine and caffeine.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Caffeine; Cisplatin; Cytara | 1985 |