caffeine has been researched along with Pain, Postoperative in 50 studies
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243." | 8.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| " Most studies used paracetamol or ibuprofen, with 100 mg to 130 mg caffeine, and the most common pain conditions studied were postoperative dental pain, postpartum pain, and headache." | 8.88 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2012) |
| "This appears to be broadly true in postoperative pain and migraine headache across a range of different drug combinations, and when tested in the same and different trials." | 6.52 | Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults. ( Derry, S; Moore, RA; Wiffen, PJ, 2015) |
| "These data do not support the hypothesis that occasional intake of a small dose of caffeine as part of pain medication imposes a health risk due to vital sign changes." | 5.69 | Lack of Evidence for Blood Pressure Effects of Caffeine Added to Ibuprofen. ( Lampert, A; Lange, R; Weiser, T, 2023) |
| " In this double-blind clinical trial, 100 patients who had anterior or premolar teeth with irreversible pulpitis without any signs and symptoms of acute or chronic apical periodontitis and moderate to severe pain were divided by balanced block random allocation into four groups of 25 each, a control group receiving a placebo medication, and three experimental groups receiving a single dose of either Tramadol (100 mg), Novafen (325 mg of paracetamol, 200 mg ibuprofen and 40 mg caffeine anhydrous) or Naproxen (500 mg) immediately after the first appointment where the pulp was removed, and the canals were fully prepared." | 5.16 | Effects of three oral analgesics on postoperative pain following root canal preparation: a controlled clinical trial. ( Abbott, PV; Asgar, K; Delvarani, A; Karamifar, K; Khabazi, H; Kharazifard, MJ; Lotfi, M; Mehrvarzfar, P; Saghiri, MA, 2012) |
| "A double-blind, cross-over trial was made of three analgesic preparations--paracetamol, paracetamol with caffeine (Finimal) and aspirin in the relief of postoperative pain in 72 orthopedic inpatients and in 144 ambulatory outpatients suffering form common idiopathic headache." | 5.04 | A double-blind comparative evaluation of aspirin, paracetamol and paracetamol + caffeine (finimal) for their analgesic effectiveness. ( Lawczyński, L; Olszewska, M; Samochowiec, L; Szwed, G; Wójcicki, J, 1977) |
| " The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243." | 4.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| " Most studies used paracetamol or ibuprofen, with 100 mg to 130 mg caffeine, and the most common pain conditions studied were postoperative dental pain, postpartum pain, and headache." | 4.88 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2012) |
| "Ibuprofen is an effective analgesic treatment with a ceiling effect at doses above 400 mg." | 2.87 | Efficacy and safety of a fixed-dose combination of ibuprofen and caffeine in the management of moderate to severe dental pain after third molar extraction. ( Hegewisch, A; Lange, R; Muse, DD; Richter, E; Weiser, T, 2018) |
| "Postoperative pain was assessed during the first 8 hours and on the following day using the 101-point numeric rate scale (NRS-101) and the four-point verbal rating scale (VRS-4)." | 2.74 | The efficacy of acetaminophen-caffeine compared to Ibuprofen in the control of postoperative pain after periodontal surgery: a crossover pilot study. ( Rashwan, WA, 2009) |
| " This trial design (crossover with multiple dosing in outpatients) is a sensitive way of testing for analgesia, and is potentially more predictive of adverse effect problems than single-dose studies." | 2.67 | A multiple dose comparison of combinations of ibuprofen and codeine and paracetamol, codeine and caffeine after third molar surgery. ( Carroll, D; Guest, P; Juniper, RP; McQuay, HJ; Moore, RA, 1992) |
| "Three hundred fifty outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned, on a double-blind basis, to receive a single oral dose of aspirin 650 or 1000 mg, caffeine 65 mg, a combination of aspirin 650 mg with caffeine 65 mg, or placebo." | 2.67 | Evaluation of aspirin, caffeine, and their combination in postoperative oral surgery pain. ( Beaver, WT; Forbes, JA; Gongloff, CM; Jones, KF; Kehm, CJ; Kroesen, M; Smith, JW; Smith, WK; Zeleznock, JR, 1990) |
| "Ibuprofen was significantly better than ACC-30 and placebo on almost all pain intensity, degree of relief and duration of analgesia parameters." | 2.65 | A double-blind comparison of ibuprofen, ASA-codeine-caffeine compound and placebo in the treatment of dental surgery pain. ( Masson, EL; Squires, DJ, 1981) |
| "This appears to be broadly true in postoperative pain and migraine headache across a range of different drug combinations, and when tested in the same and different trials." | 2.52 | Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults. ( Derry, S; Moore, RA; Wiffen, PJ, 2015) |
| "Caffeine has been an additive in analgesics for many years." | 2.41 | A benefit-risk assessment of caffeine as an analgesic adjuvant. ( Zhang, WY, 2001) |
| "Caffeine did not enhance the analgesic effect of aspirin." | 2.40 | Do codeine and caffeine enhance the analgesic effect of aspirin?--A systematic overview. ( Po, AL; Zhang, WY, 1997) |
| "Ibuprofen is an effective analgesic in post-operative pain." | 2.40 | Analgesic efficacy of ibuprofen alone and in combination with codeine or caffeine in post-surgical pain: a meta-analysis. ( Po, AL; Zhang, WY, 1998) |
| "The objective of this study was to quantify the analgesic efficacy of paracetamol and its combination with codeine or caffeine through a systematic overview and meta-analysis of relevant randomized controlled trials (RCTs)." | 2.39 | Analgesic efficacy of paracetamol and its combination with codeine and caffeine in surgical pain--a meta-analysis. ( Li Wan Po, A; Zhang, WY, 1996) |
| "The adenosinergic system was assessed by systemic (intraperitoneal), central (intrathecal), and peripheral (intraplantar) administration of caffeine." | 1.39 | Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors. ( Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (40.00) | 18.7374 |
| 1990's | 9 (18.00) | 18.2507 |
| 2000's | 4 (8.00) | 29.6817 |
| 2010's | 13 (26.00) | 24.3611 |
| 2020's | 4 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lampert, A | 2 |
| Lange, R | 3 |
| Weiser, T | 3 |
| Musselman, E | 1 |
| Stannard, D | 1 |
| Förderreuther, S | 1 |
| Hitier, S | 1 |
| Vlisides, PE | 1 |
| Li, D | 1 |
| McKinney, A | 1 |
| Brooks, J | 1 |
| Leis, AM | 1 |
| Mentz, G | 1 |
| Tsodikov, A | 1 |
| Zierau, M | 1 |
| Ragheb, J | 1 |
| Clauw, DJ | 1 |
| Avidan, MS | 1 |
| Vanini, G | 2 |
| Mashour, GA | 1 |
| Richter, E | 1 |
| Hegewisch, A | 1 |
| Muse, DD | 1 |
| Samieirad, S | 1 |
| Afrasiabi, H | 1 |
| Tohidi, E | 1 |
| Qolizade, M | 1 |
| Shaban, B | 1 |
| Hashemipour, MA | 1 |
| Doaltian Shirvan, I | 1 |
| Hambrecht-Wiedbusch, VS | 1 |
| Gabel, M | 1 |
| Liu, LJ | 1 |
| Imperial, JP | 1 |
| Colmenero, AV | 1 |
| Brignardello-Petersen, R | 1 |
| Derry, CJ | 2 |
| Derry, S | 3 |
| Moore, RA | 5 |
| Wiffen, PJ | 1 |
| Bergese, S | 1 |
| Castellon-Larios, K | 1 |
| Rashwan, WA | 1 |
| Farouk, S | 1 |
| Aly, A | 1 |
| Borel, JF | 1 |
| Deschaumes, C | 1 |
| Devoize, L | 1 |
| Huard, C | 1 |
| Orliaguet, T | 1 |
| Dubray, C | 1 |
| Baudet-Pommel, M | 1 |
| Dallel, R | 1 |
| Mehrvarzfar, P | 1 |
| Abbott, PV | 1 |
| Saghiri, MA | 1 |
| Delvarani, A | 1 |
| Asgar, K | 1 |
| Lotfi, M | 1 |
| Karamifar, K | 1 |
| Kharazifard, MJ | 1 |
| Khabazi, H | 1 |
| Hunter, BR | 1 |
| Seupaul, RA | 1 |
| Mitchell, A | 2 |
| McCrea, P | 1 |
| Inglis, K | 2 |
| Porter, G | 2 |
| Martins, DF | 1 |
| Mazzardo-Martins, L | 1 |
| Cidral-Filho, FJ | 1 |
| Stramosk, J | 1 |
| Santos, AR | 1 |
| van Zanten, SV | 1 |
| MacKay, IS | 1 |
| Ananian, V | 1 |
| Laska, EM | 2 |
| Sunshine, A | 2 |
| Mueller, F | 1 |
| Elvers, WB | 1 |
| Siegel, C | 1 |
| Rubin, A | 1 |
| Buttram, VC | 1 |
| Gravlee, LC | 1 |
| Hale, RW | 1 |
| Lifshitz, S | 1 |
| Zighelboim, I | 1 |
| Roure, C | 1 |
| Marrero, I | 1 |
| Wanderling, J | 1 |
| Olson, N | 1 |
| Ladwa, RA | 1 |
| White, P | 1 |
| Strunin, L | 1 |
| Baird, WM | 1 |
| Turek, D | 1 |
| Mehlisch, DR | 2 |
| Joy, ED | 2 |
| Moore, TE | 1 |
| Porter, K | 1 |
| Stumpf, AJ | 1 |
| Wolfe, SH | 1 |
| Messer, RH | 1 |
| Vaughn, T | 1 |
| Harbert, G | 1 |
| Squires, DJ | 1 |
| Masson, EL | 1 |
| McQuay, HJ | 2 |
| Angell, K | 1 |
| Carroll, D | 2 |
| Juniper, RP | 2 |
| Zhang, WY | 4 |
| Li Wan Po, A | 1 |
| Po, AL | 2 |
| Gardos, G | 1 |
| Hellem, S | 1 |
| Persson, G | 1 |
| Freiberg, N | 1 |
| Nord, PG | 1 |
| Gustafsson, B | 1 |
| Huitfeldt, B | 1 |
| Wójcicki, J | 1 |
| Samochowiec, L | 1 |
| Lawczyński, L | 1 |
| Szwed, G | 1 |
| Olszewska, M | 1 |
| Middleton, RA | 1 |
| Upton, LG | 1 |
| Le Roux, PA | 1 |
| Guest, P | 1 |
| Lyall, JB | 1 |
| Forbes, JA | 2 |
| Beaver, WT | 2 |
| Jones, KF | 2 |
| Kehm, CJ | 2 |
| Smith, WK | 2 |
| Gongloff, CM | 2 |
| Zeleznock, JR | 2 |
| Smith, JW | 2 |
| Habib, S | 1 |
| Matthews, RW | 1 |
| Scully, C | 1 |
| Levers, BG | 1 |
| Shepherd, JP | 1 |
| Kroesen, M | 1 |
| Dupuis, R | 1 |
| Lemay, H | 1 |
| Bushnell, MC | 1 |
| Duncan, GH | 1 |
| Engelmayer, K | 1 |
| Bloch, B | 1 |
| Smythe, E | 1 |
| Weeks, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single-centre, Double-blind, Randomised, Two-stage, Parallel-group Study to Assess the Efficacy and Safety of the Fixed Dose Combination of Ibuprofen 400 mg and Caffeine 100 mg Versus Ibuprofen 400 mg, Caffeine 100 mg and Placebo in Patients With Postop[NCT01929031] | Phase 3 | 562 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| Caffeine and Neurologic Recovery Following Surgery and General Anesthesia[NCT03577730] | Early Phase 1 | 71 participants (Actual) | Interventional | 2018-07-10 | Completed | ||
| The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study[NCT05574400] | Phase 2 | 250 participants (Anticipated) | Interventional | 2023-02-20 | Recruiting | ||
| Demonstration of OTC Naproxen Sodium's (Aleve's) Anti-inflammatory Action in Dental Implant Surgery Patients[NCT04694300] | Phase 4 | 32 participants (Actual) | Interventional | 2021-02-07 | Completed | ||
| Does Magnesium Sulfate as a Supplement in Adductor Canal Blocks Improve Pain Control After Total Knee Arthroplasty?[NCT02581683] | Phase 4 | 130 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Comparison of the Efficacy of Prophylactic Intraligamentary Injection of Piroxicam Versus Mepecaine for Management of Post-endodontic Pain in Posterior Teeth[NCT03006107] | 26 participants (Anticipated) | Interventional | 2016-12-31 | Not yet recruiting | |||
| Post-operative Analgesia in Elective, Soft-tissue Hand Surgery: A Randomized, Double Blind Comparison of Acetaminophen/Ibuprofen Versus Acetaminophen/Hydrocodone[NCT02029235] | Phase 4 | 72 participants (Actual) | Interventional | 2015-02-10 | Terminated (stopped due to Early termination due to slower than anticipated recruitment.) | ||
| Achieving Peri-Operative Pain Control Without Opioids[NCT04813991] | Phase 3 | 0 participants (Actual) | Interventional | 2022-03-15 | Withdrawn (stopped due to Enrollment was never initiated and the PI is leaving the institution so the study is closing.) | ||
| A Randomized Trial Comparing Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Outpatient Soft Tissue Hand Surgery[NCT03111186] | Phase 2 | 40 participants (Actual) | Interventional | 2017-04-24 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Duration of pain relief was defined as the time between the administration of first dose of trial medication and first dose of rescue medication or second dose of trial medication, whichever was first. Duration of pain relief was censored at 8 hours. (NCT01929031)
Timeframe: 8 hours
| Intervention | hours (Median) |
|---|---|
| Placebo | 1.63 |
| Caffeine | 2.08 |
| Ibuprofen | 7.11 |
| Ibuprofen/Caffeine | 7.33 |
Time to meaningful pain relief was captured by a stopwatch, which was started by the study staff immediately after the administration of the first dose of trial medication and which was to be stopped by the patient as soon as he/she felt meaningful pain relief. Time to meaningful pain relief was censored at 8 hours. (NCT01929031)
Timeframe: 8 hours
| Intervention | hours (Median) |
|---|---|
| Placebo | NA |
| Caffeine | NA |
| Ibuprofen | 1.78 |
| Ibuprofen/Caffeine | 1.13 |
SPRID0-2h: Time-weighted sum of PAR and PID from 0 to 2 hours, score range: -10 (worst) to 28 (best). PI was assessed on a 0-10 numerical pain rating scale (NPRS), where 0=no pain and 10=worst possible pain, pre-dose and at 0.25,0.5,0.75,1,1.5 and 2 hours; PAR was assessed on a 5-point verbal rating scale (VRS) (0=none to 4=complete) at the same post-dose time points. Time-weights were equal to the elapsed time (hour) between the time point of interest and the preceding time point. All PAR and pain intensity (PI) assessments completed after the patient had taken rescue medication or the second dose of study medication, whichever was first, until hour 2 was considered missing. Last observation carried forward (LOCF) was used with the last completed PI/PAR assessments prior to first rescue/second study medication, whichever was first, to impute missing values up to 2 hours. (NCT01929031)
Timeframe: 0 to 2 hours
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | 2.059 |
| Caffeine | 2.612 |
| Ibuprofen | 6.990 |
| Ibuprofen/Caffeine | 10.584 |
SPRID0-8h: Time-weighted sum of PAR and PID from 0 to 8 hours, score range: -40 (worst) to 112 (best). PI was assessed on a 0-10 numerical pain rating scale (NPRS), where 0=no pain and 10=worst possible pain, pre-dose and at 0.25,0.5,0.75,1,1.5,2,3,4,5, 6,7 and 8 hours; PAR was assessed on a 5-point verbal rating scale (VRS) (0=none to 4=complete) at the same post-dose time points. Time-weights were equal to the elapsed time (hour) between the time point of interest and the preceding time point. All PAR and pain intensity (PI) assessments completed after the patient had taken rescue medication or the second dose of study medication, whichever was first, until hour 8 were considered missing. Last observation carried forward (LOCF) was used with the last completed PI/PAR assessments prior to first rescue/second study medication, whichever was first, to impute missing values up to 8 hours. (NCT01929031)
Timeframe: 0 to 8 hours
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | 10.554 |
| Caffeine | 15.824 |
| Ibuprofen | 40.165 |
| Ibuprofen/Caffeine | 52.291 |
Behavioral Pain Scale, on a scale ranging from 3 to 12 when 3 is no pain and 12 is maximum pain (NCT03577730)
Timeframe: Data gathered from postoperative day 0-3. Final results were based on all values combined over this time period, per protocol.
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 3 |
| Control | 3 |
Visual Analogue Scale (mm, 0-100, 0 = no pain, 100 = worst pain imaginable) (NCT03577730)
Timeframe: Data gathered from postoperative day 0-3. Final results were based on all values combined over this time period, per protocol.
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 40 |
| Control | 39 |
Trail Making Test scores (seconds, 10-300,10 = fastest reported completion, 300 = maximum time allowed for completion). The change was calculated from the value at post anesthesia minus value at baseline. Higher values are considered to be worse outcomes. (NCT03577730)
Timeframe: morning of surgery baseline compared to postanesthesia care unit. Postanesthesia care unit measurement approximately 60 minutes after end of surgery
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 10 |
| Control | 16 |
Postoperative opioid consumption, oral morphine equivalents (mg) (NCT03577730)
Timeframe: through postoperative day 3
| Intervention | oral morphine equivalents (mg) (Median) |
|---|---|
| Experimental | 77 |
| Control | 51 |
Negative Affect Score (n, 10-50, 10 = least negative affect, 50 = most negative affect) via PANAS (Positive and Negative Affect Schedule) (NCT03577730)
Timeframe: postoperative day 3
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 12 |
| Control | 12 |
Number (n) of participants with positive screens (score ≥8) using the Hospitalized Anxiety and Depression Scale (HADS-A) (n, 0-21, 0 = normal, 21 = presence of severe anxiety symptoms) (NCT03577730)
Timeframe: baseline through postoperative day 3
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental | 2 |
| Control | 2 |
Number (n) of participants with positive screens (score ≥8) using the Hospitalized Anxiety and Depression Scale (HADS-D) (n, 0-21, 0 = normal, 21 = presence of severe depression symptoms) (NCT03577730)
Timeframe: baseline through postoperative day 3
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental | 2 |
| Control | 1 |
Number (n) of participants who has experienced at least one episode of delirium by the postoperative day 3 time point, as determined by daily Confusion Assessment Method (CAM). (NCT03577730)
Timeframe: By afternoon of postoperative day (POD) 3
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental | 7 |
| Control | 14 |
Positive Affect Score (n, 10-50, 10 = least positive affect, 50 = most positive affect) via PANAS (Positive and Negative Affect Schedule) (NCT03577730)
Timeframe: postoperative day 3
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 35 |
| Control | 35 |
Self-report instrument for measuring sleep quality. Visual Analogue Scale (mm, 0-100, 0 =Deep sleep , 100 =Light sleep) (NCT03577730)
Timeframe: Preoperative (once before surgery on day of surgery)
| Intervention | score on a scale (Mean) |
|---|---|
| Experimental | 58 |
| Control | 56 |
Time from surgical dressing on to anesthetic emergence (min) (NCT03577730)
Timeframe: Duration of time from surgical dressing completion to anesthetic emergence (min); generally expected to be between 10 and 60 minutes
| Intervention | Minutes (Median) |
|---|---|
| Experimental | 8 |
| Control | 10 |
"Subjects asked to fill out a patient diary recording their pain intensity level (on 100mm Visual Analog Scale) prior to taking study medication every 4 hours.~The daily average pain intensity levels are reported as a score on a scale of 0-100, with higher score meaning worse outcome.~The daily average pain levels were assessed daily for 1 week post-operatively, then compared between the 2 groups using a two-group Student's t-test." (NCT02029235)
Timeframe: 1 week post-operatively
| Intervention | score on a scale (0-100, higher = worse) (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| Daily average pain intensity level on PostOp Day 1 | Daily average pain intensity level on PostOp Day 2 | Daily average pain intensity level on PostOp Day 3 | Daily average pain intensity levelon PostOp Day 4 | Daily average pain intensity level on PostOp Day 5 | Daily average pain intensity level on PostOp Day 6 | Daily average pain intensity level on PostOp Day 7 | |
| Acetaminophen/Hydrocodone (AH) Group | 24.07 | 30.16 | 22.11 | 18.53 | 16.61 | 13.58 | 13.00 |
| Acetaminophen/Ibuprofen (AIBU) Group | 22.17 | 22.22 | 15.67 | 13.17 | 14.03 | 13.44 | 12.67 |
"Subjects asked to fill out a patient diary recording their pain relief (on a Likert scale) one hour after taking study medication every 4 hours.~Daily average pain relief scores are reported as a score on a scale of 0-3, with higher score meaning better outcome.~The daily average pain relief scores were assessed daily for 1 week post-operatively, then compared using generalized linear mixed-effects models" (NCT02029235)
Timeframe: 1 week postoperatively
| Intervention | score on a scale (0-3, higher = better) (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| Daily average pain relief on PostOp Day 1 | Daily average pain relief on PostOp Day 2 | Daily average pain relief on PostOp Day 3 | Daily average pain relief on PostOp Day 4 | Daily average pain relief on PostOp Day 5 | Daily average pain relief on PostOp Day 6 | Daily average pain relief on PostOp Day 7 | |
| Acetaminophen/Hydrocodone (AH) Group | 1.53 | 1.76 | 2.33 | 2.46 | 2.54 | 2.84 | 2.88 |
| Acetaminophen/Ibuprofen (AIBU) Group | 1.84 | 2.27 | 2.63 | 2.91 | 2.88 | 2.87 | 2.96 |
8 reviews available for caffeine and Pain, Postoperative
| Article | Year |
|---|---|
Caffeine as an analgesic adjuvant for acute pain in adults.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics; Caffeine; Chemotherapy, Adjuvant; Di | 2014 |
Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics, Non-Narcotic; Caffeine; Drug Combinations; Humans; Ibuprofen; Numbers | 2015 |
Caffeine as an analgesic adjuvant for acute pain in adults.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Caffeine; Chemotherapy, Adjuvant; Female; Headache; Hu | 2012 |
Are there pharmacologic agents that safely and effectively treat post-lumbar puncture headache?
Topics: Adrenocorticotropic Hormone; Caffeine; Central Nervous System Stimulants; Headache; Humans; Injectio | 2013 |
Analgesic efficacy of paracetamol and its combination with codeine and caffeine in surgical pain--a meta-analysis.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Caffeine; Codeine | 1996 |
Do codeine and caffeine enhance the analgesic effect of aspirin?--A systematic overview.
Topics: Analgesia; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Central N | 1997 |
Analgesic efficacy of ibuprofen alone and in combination with codeine or caffeine in post-surgical pain: a meta-analysis.
Topics: Adult; Anesthetics, Combined; Caffeine; Codeine; Dose-Response Relationship, Drug; Drug Synergism; H | 1998 |
A benefit-risk assessment of caffeine as an analgesic adjuvant.
Topics: Adjuvants, Pharmaceutic; Analgesics; Animals; Caffeine; Drug Antagonism; Female; Headache; Headache | 2001 |
33 trials available for caffeine and Pain, Postoperative
| Article | Year |
|---|---|
Lack of Evidence for Blood Pressure Effects of Caffeine Added to Ibuprofen.
Topics: Analgesics, Non-Narcotic; Blood Pressure; Caffeine; Double-Blind Method; Humans; Ibuprofen; Pain; Pa | 2023 |
The Impact of Baseline Pain Intensity on the Analgesic Efficacy of Ibuprofen/Caffeine in Patients with Acute Postoperative Dental Pain: Post Hoc Subgroup Analysis of a Randomised Controlled Trial.
Topics: Acute Pain; Adolescent; Adult; Analgesics; Caffeine; Dose-Response Relationship, Drug; Double-Blind | 2020 |
The Effects of Intraoperative Caffeine on Postoperative Opioid Consumption and Related Outcomes After Laparoscopic Surgery: A Randomized Controlled Trial.
Topics: Adult; Aged; Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Double-Blind Method; F | 2021 |
The Effects of Intraoperative Caffeine on Postoperative Opioid Consumption and Related Outcomes After Laparoscopic Surgery: A Randomized Controlled Trial.
Topics: Adult; Aged; Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Double-Blind Method; F | 2021 |
The Effects of Intraoperative Caffeine on Postoperative Opioid Consumption and Related Outcomes After Laparoscopic Surgery: A Randomized Controlled Trial.
Topics: Adult; Aged; Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Double-Blind Method; F | 2021 |
The Effects of Intraoperative Caffeine on Postoperative Opioid Consumption and Related Outcomes After Laparoscopic Surgery: A Randomized Controlled Trial.
Topics: Adult; Aged; Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Double-Blind Method; F | 2021 |
Efficacy and safety of a fixed-dose combination of ibuprofen and caffeine in the management of moderate to severe dental pain after third molar extraction.
Topics: Adolescent; Adult; Analgesics; Caffeine; Double-Blind Method; Drug Combinations; Female; Humans; Ibu | 2018 |
Evaluation of caffeine versus codeine for pain and swelling management after implant surgeries: A triple blind clinical trial.
Topics: Adult; Analgesics, Opioid; Caffeine; Codeine; Dental Implantation; Double-Blind Method; Edema; Femal | 2017 |
The efficacy of acetaminophen-caffeine compared to Ibuprofen in the control of postoperative pain after periodontal surgery: a crossover pilot study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; C | 2009 |
A comparison of intra-articular magnesium and/or morphine with bupivacaine for postoperative analgesia after arthroscopic knee surgery.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Anesthetics, Local; Arthroscopy; Bupivacaine; Caffeine; Co | 2009 |
[Treating pain after dental surgery: a randomised, controlled, double-blind trial to assess a new formulation of paracetamol, opium powder and caffeine versus tramadol or placebo].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Caffeine; Central Nervous System Stimul | 2010 |
Effects of three oral analgesics on postoperative pain following root canal preparation: a controlled clinical trial.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid | 2012 |
A randomized, controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine (Tylenol 3) after outpatient breast surgery.
Topics: Acetaminophen; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Breast Neoplasms; Ca | 2012 |
A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery.
Topics: Acetaminophen; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics; Caffeine; Centra | 2008 |
A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery.
Topics: Acetaminophen; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics; Caffeine; Centra | 2008 |
A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery.
Topics: Acetaminophen; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics; Caffeine; Centra | 2008 |
A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery.
Topics: Acetaminophen; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics; Caffeine; Centra | 2008 |
Analgesia following adult tonsillectomy: a comparative study of solpadeine and a soluble form of dextropropoxyphene napsylate and paracetamol.
Topics: Acetaminophen; Adult; Aged; Analgesics; Caffeine; Codeine; Dextropropoxyphene; Drug Combinations; Dr | 1982 |
Caffeine as an analgesic adjuvant.
Topics: Acetaminophen; Adjuvants, Pharmaceutic; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Dou | 1984 |
Naproxen sodium vs. a combination of aspirin, phenacetin, caffeine and codeine phosphate for pain after major gynecologic surgery. A multicenter comparison.
Topics: Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Female | 1984 |
Effect of caffeine on acetaminophen analgesia.
Topics: Acetaminophen; Analgesia; Analysis of Variance; Caffeine; Dose-Response Relationship, Drug; Drug Com | 1983 |
Comparison of zomepirac, APC with codeine, codeine and placebo in the treatment of moderate and severe postoperative pain.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Female; | 1980 |
Clinical comparison of zomepirac with APC/codeine combination in the treatment of pain following oral surgery.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Female; | 1980 |
Clinical evaluation of zomepirac and APC with codeine in the treatment of postpartum episiotomy pain.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Episioto | 1980 |
Zomepirac sodium vs APC with codeine for oral surgery pain.
Topics: Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Humans | 1981 |
A double-blind comparison of ibuprofen, ASA-codeine-caffeine compound and placebo in the treatment of dental surgery pain.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Clinical Trials as Topic; Codeine | 1981 |
Ibuprofen compared with ibuprofen plus caffeine after third molar surgery.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Central Nervous System Stimulants; Double- | 1996 |
A model for evaluating the analgesic effect of a new fixed ratio combination analgesic in patients undergoing oral surgery.
Topics: Adult; Analgesics; Antipyrine; Aspirin; Caffeine; Dextropropoxyphene; Drug Combinations; Drug Evalua | 1979 |
A double-blind comparative evaluation of aspirin, paracetamol and paracetamol + caffeine (finimal) for their analgesic effectiveness.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Clinical Trials as Topic; Drug Therapy, C | 1977 |
Postoperative evaluation of combined analgesic/sedative.
Topics: Anxiety; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Humans; Pain, Post | 1978 |
Evaluation of sedative/analgesic combination for postoperative pain.
Topics: Anxiety; Aspirin; Caffeine; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Drug E | 1979 |
The analgesic effect of Syndol following neurosurgery and neurosurgical procedures.
Topics: Acetaminophen; Adult; Caffeine; Clinical Trials as Topic; Codeine; Doxylamine; Drug Combinations; Fe | 1975 |
A multiple dose comparison of combinations of ibuprofen and codeine and paracetamol, codeine and caffeine after third molar surgery.
Topics: Acetaminophen; Administration, Oral; Adult; Caffeine; Codeine; Double-Blind Method; Drug Combination | 1992 |
Third molar surgery: the effect of primary closure, wound dressing and metronidazole on postoperative recovery.
Topics: Acetaminophen; Adult; Analgesics; Bandages; Bismuth; Caffeine; Codeine; Drug Combinations; Female; H | 1991 |
Effect of caffeine on ibuprofen analgesia in postoperative oral surgery pain.
Topics: Adolescent; Adult; Analgesia; Analysis of Variance; Caffeine; Dentistry, Operative; Drug Therapy, Co | 1991 |
A study of the comparative efficacy of four common analgesics in the control of postsurgical dental pain.
Topics: Acetaminophen; Adult; Analgesics; Analysis of Variance; Aspirin; Caffeine; Codeine; Drug Combination | 1990 |
Evaluation of aspirin, caffeine, and their combination in postoperative oral surgery pain.
Topics: Administration, Oral; Adolescent; Adult; Aspirin; Caffeine; Double-Blind Method; Drug Therapy, Combi | 1990 |
Preoperative flurbiprofen in oral surgery: a method of choice in controlling postoperative pain.
Topics: Adult; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Combinations; Female; Flurbiprofen | 1988 |
Analgesics for pain relief after gynaecological surgery. A two-phase study.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics; Benzophenones; Caffeine; Clinical Trials as | 1985 |
9 other studies available for caffeine and Pain, Postoperative
| Article | Year |
|---|---|
Single-Dose Oral Ibuprofen Plus Caffeine for Acute Postoperative Pain in Adults.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Central Nervous Syst | 2020 |
Preemptive Caffeine Administration Blocks the Increase in Postoperative Pain Caused by Previous Sleep Loss in the Rat: A Potential Role for Preoptic Adenosine A2A Receptors in Sleep-Pain Interactions.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Female; Hyperalgesia; Male; Pain, Postoperativ | 2017 |
Acetaminophen plus caffeine or plus codeine probably results in less pain but more swelling in patients undergoing placement of a single implant without bone grafting in the posterior zone.
Topics: Acetaminophen; Bone Transplantation; Caffeine; Codeine; Humans; Pain, Postoperative | 2018 |
The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults.
Topics: Acute Pain; Analgesics, Non-Narcotic; Caffeine; Humans; Ibuprofen; Pain, Postoperative | 2016 |
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal; | 2013 |
Comparison of Syndol and paracetamol in the relief of dental pain.
Topics: Acetaminophen; Adolescent; Adult; Aged; Caffeine; Codeine; Double-Blind Method; Doxylamine; Drug Com | 1981 |
Post-anaesthetic dental extraction analgesia: a comparison of paracetamol, codeine, caffeine (Solpadeine) and diflunisal (Dolobid).
Topics: Acetaminophen; Adolescent; Adult; Aged; Anesthesia, Dental; Anesthesia, General; Caffeine; Codeine; | 1982 |
Dyskinesia after discountinuation of compound analgesic containing oxycodone.
Topics: Aspirin; Caffeine; Codeine; Drug Combinations; Female; Humans; Middle Aged; Movement Disorders; Oxyc | 1977 |
[Efficacy of Dolomo T/N in practical use].
Topics: Adult; Aged; Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Humans; Middle Aged; Pa | 1985 |