Page last updated: 2024-10-24

caffeine and Osteoporosis

caffeine has been researched along with Osteoporosis in 45 studies

Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.

Research Excerpts

ExcerptRelevanceReference
"Epidemiologic investigations suggest that excessive intake of caffeine during pregnancy is one of the risk factors for osteoporosis in adult offspring."7.88Intrauterine Programming of Glucocorticoid-Insulin-Like Growth Factor-1 Axis-Mediated Developmental Origin of Osteoporosis Susceptibility in Female Offspring Rats with Prenatal Caffeine Exposure. ( Chen, L; Jiang, H; Magdalou, J; Qin, J; Shangguan, Y; Tan, Y; Wang, H; Wen, Y, 2018)
"When caffeine intake was categorized by source, no consistent influence of coffee, tea, or other caffeinated beverage consumption could be detected on bone mineral."5.28Is caffeine consumption a risk factor for osteoporosis? ( Atkinson, EJ; Cooper, C; Judd, HL; Melton, LJ; O'Fallon, WM; Riggs, BL; Wahner, HW, 1992)
"Caffeine negatively mediates bone homeostasis to cause bone loss and even osteoporosis."3.88β-Estradiol antagonizes the inhibitory effects of caffeine in BMMSCs via the ERβ-mediated cAMP-dependent PKA pathway. ( Guan, X; Wang, C; Wang, H; Yu, M; Zhou, Y, 2018)
"Epidemiologic investigations suggest that excessive intake of caffeine during pregnancy is one of the risk factors for osteoporosis in adult offspring."3.88Intrauterine Programming of Glucocorticoid-Insulin-Like Growth Factor-1 Axis-Mediated Developmental Origin of Osteoporosis Susceptibility in Female Offspring Rats with Prenatal Caffeine Exposure. ( Chen, L; Jiang, H; Magdalou, J; Qin, J; Shangguan, Y; Tan, Y; Wang, H; Wen, Y, 2018)
"Caffeine, a methylxanthine present in coffee, has been postulated to be responsible for an increased risk of osteoporosis in coffee drinkers; however, the data are inconsistent."3.79Favorable effect of moderate dose caffeine on the skeletal system in ovariectomized rats. ( Cegieła, U; Folwarczna, J; Kaczmarczyk-Sedlak, I; Nowińska, B; Pytlik, M; Sliwiński, L; Zych, M, 2013)
" Correlates associated with both cortical and trabecular vBMD were age (-), caffeine intake (-), total calcium intake (+), nontrauma fracture (-), and hypertension (+)."3.76Correlates of trabecular and cortical volumetric bone mineral density of the radius and tibia in older men: the Osteoporotic Fractures in Men Study. ( Barbour, KE; Boudreau, R; Cauley, JA; Ensrud, KE; Evans, RW; Gordon, CL; Horwitz, MJ; Petit, MA; Strotmeyer, ES; Zmuda, JM, 2010)
"Caffeine increases urinary calcium output and has been implicated as a risk factor for osteoporosis."3.68Caffeine and the risk of hip fracture: the Framingham Study. ( Anderson, JJ; Felson, DT; Hannan, MT; Kiel, DP; Wilson, PW, 1990)
"Sarcopenia and osteoporosis are important public health problems that occur concurrently."1.40METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway. ( Abreu, E; Bonewald, LF; Brotto, M; Hsu, YH; Huang, J; Karasik, D; Kiel, DP; Mo, C, 2014)
"The prevalence of osteoporosis and osteopenia were 8."1.36Risk factors of osteoporosis in healthy Moroccan men. ( Dehhaoui, M; El Maghraoui, A; Gassim, S; Ghazi, M; Ghozlani, I; Mounach, A; Rezqi, A, 2010)
"Vertebral and hip fractures are associated with an increased risk of death."1.35Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study. ( Adachi, JD; Akhtar-Danesh, N; Anastassiades, T; Brown, JP; Davison, KS; Gafni, A; Goltzman, D; Hanley, DA; Hopman, WM; Ioannidis, G; Josse, RG; Kennedy, CC; Olszynski, WP; Papadimitropoulos, EA; Papaioannou, A; Pickard, L; Prior, JC; Thabane, L, 2009)
"Caffeine intake was measured from diet records and by gas chromatography of each subject's brewed, caffeinated beverages."1.30Dietary caffeine intake and bone status of postmenopausal women. ( Chinchilli, VM; Eggli, DF; Kieselhorst, K; Lloyd, T; Rollings, N, 1997)
"When caffeine intake was categorized by source, no consistent influence of coffee, tea, or other caffeinated beverage consumption could be detected on bone mineral."1.28Is caffeine consumption a risk factor for osteoporosis? ( Atkinson, EJ; Cooper, C; Judd, HL; Melton, LJ; O'Fallon, WM; Riggs, BL; Wahner, HW, 1992)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19906 (13.33)18.7374
1990's10 (22.22)18.2507
2000's13 (28.89)29.6817
2010's13 (28.89)24.3611
2020's3 (6.67)2.80

Authors

AuthorsStudies
Berman, NK1
Honig, S1
Cronstein, BN1
Pillinger, MH1
Chau, YP1
Au, PCM1
Li, GHY1
Sing, CW1
Cheng, VKF1
Tan, KCB1
Kung, AWC1
Cheung, CL1
Xiao, H1
Wu, Z1
Li, B1
Shangguan, Y2
Stoltz, JF1
Magdalou, J2
Chen, L2
Wang, H3
Folwarczna, J2
Janas, A1
Cegieła, U2
Pytlik, M2
Śliwiński, L2
Matejczyk, M1
Nowacka, A1
Rudy, K1
Krivošíková, Z1
Štefíková, K1
Gajdoš, M1
Wang, C1
Zhou, Y3
Guan, X1
Yu, M1
Wen, Y1
Tan, Y1
Qin, J1
Jiang, H1
Zych, M1
Kaczmarczyk-Sedlak, I1
Nowińska, B1
Hallström, H2
Byberg, L1
Glynn, A2
Lemming, EW1
Wolk, A2
Michaëlsson, K2
Huang, J1
Hsu, YH1
Mo, C1
Abreu, E1
Kiel, DP3
Bonewald, LF1
Brotto, M1
Karasik, D1
de França, NA1
Camargo, MB1
Lazaretti-Castro, M1
Peters, BS1
Martini, LA1
Huitrón-Bravo, G1
Denova-Gutiérrez, E1
Talavera, JO1
Moran-Villota, C1
Tamayo, J1
Omaña-Covarrubias, A1
Salmerón, J1
Zhu, ZL2
Guan, XX2
Hou, WW2
Yu, HY2
Pedrera-Zamorano, JD1
Lavado-Garcia, JM1
Roncero-Martin, R1
Calderon-Garcia, JF1
Rodriguez-Dominguez, T1
Canal-Macias, ML1
Ioannidis, G1
Papaioannou, A1
Hopman, WM1
Akhtar-Danesh, N1
Anastassiades, T1
Pickard, L1
Kennedy, CC1
Prior, JC1
Olszynski, WP1
Davison, KS1
Goltzman, D1
Thabane, L1
Gafni, A1
Papadimitropoulos, EA1
Brown, JP1
Josse, RG1
Hanley, DA1
Adachi, JD1
Barbour, KE1
Zmuda, JM1
Strotmeyer, ES1
Horwitz, MJ1
Boudreau, R1
Evans, RW1
Ensrud, KE1
Petit, MA1
Gordon, CL1
Cauley, JA1
Jha, RM1
Mithal, A1
Malhotra, N1
Brown, EM1
El Maghraoui, A1
Ghazi, M1
Gassim, S1
Ghozlani, I1
Mounach, A1
Rezqi, A1
Dehhaoui, M1
Guo, J1
Huang, YC1
Hermansen, K1
Krogholm, KS1
Bech, BH1
Dragsted, LO1
Hyldstrup, L1
Jørgensen, K1
Larsen, ML1
Tjønneland, AM1
Esposito, A1
Setola, C1
Del Puente, A1
Tsukahara, N1
Ezawa, I1
Budak, N1
Ciçek, B1
Sahin, H1
Tutus, A1
Higdon, JV1
Frei, B1
George, SE1
Ramalakshmi, K1
Mohan Rao, LJ1
Heaney, RP1
Wolinsky-Friedland, M1
Felson, DT2
Hannan, MT2
Anderson, JJ2
Wilson, PW2
Barrett-Connor, E1
Chang, JC1
Edelstein, SL1
Maini, M1
Brignoli, E1
Felicetti, G1
Bozzi, M1
Lloyd, T1
Rollings, N1
Eggli, DF1
Kieselhorst, K1
Chinchilli, VM1
Meltzer, E1
Dolev, E1
Freeman, D1
Randall, DB1
Massey, LK2
Fujiwara, S1
Boross, M1
Cooper, C1
Atkinson, EJ1
Wahner, HW1
O'Fallon, WM1
Riggs, BL1
Judd, HL1
Melton, LJ1
Urrows, ST1
Freston, MS1
Pryor, DL1
Wyngaarden, JB1
Schaafsma, G1
van Beresteyn, EC1
Raymakers, JA1
Duursma, SA1
Sutnick, MR1
Spencer, H1
Kramer, L1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Finding the Optimal Resistance Training Intensity For Your Bones: A Randomized Controlled Trial (FORTIFY Bones)[NCT05541432]324 participants (Anticipated)Interventional2022-09-13Recruiting
Tailored Exercise for Fall and Fracture Prevention in Older Adults: A Family Health Team Approach[NCT01698463]11 participants (Actual)Interventional2012-01-31Completed
Neuroplastic Alterations of the Motor Cortex by Caffeine: Differences Between Caffeine and Non-caffeine Users and Influence of Vigilance During Stimulation[NCT04011670]30 participants (Actual)Interventional2019-07-15Completed
Effect of Coffee and Tea Consumption on Adolescent Weight Control - a Randomized Clinical Trial[NCT05181176]63 participants (Anticipated)Interventional2021-01-01Recruiting
Cortical Excitability Changes on the Sensorimotor Cortex Induced by Caffeine Consumption: A TMS Study[NCT03720665]30 participants (Actual)Interventional2018-10-01Completed
Does Caffeine Enhance Bowel Recovery After Colorectal Surgery?[NCT03097900]Phase 270 participants (Actual)Interventional2017-11-02Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Behavior Change Outcome: Action Planning

"A psychometric questionnaire will assess action planning using a likert scale at baseline and 6 weeks follow-up.~Action Planning: when, where and how an individual will engage in the recommended exercise. Psychometric questionnaire assessing Action Planning was administered at baseline and follow-up. The psychometric questionnaire used a 5 point likert scale. (0 represents worst performance) to 25 (best performance)." (NCT01698463)
Timeframe: Baseline, 6 week follow-up

Interventionunits on a scale (Mean)
Identify Patients at Risk/Exercise Prescription21.00

Behavior Change Outcome: Coping Planning

"A psychometric questionnaire will assess coping planning using a likert scale at baseline and 6 weeks follow-up.~Coping Planning: assesses an individuals ability to overcome perceived barriers e.g. lack of time, poor weather. Psychometric questionnaire assessing coping planning was administered at baseline and follow-up. The psychometric questionnaire used a 5 point likert scale. (0 represents worst performance) to 20 (best performance)." (NCT01698463)
Timeframe: Baseline, 6 week follow-up

Interventionunits on a scale (Mean)
Identify Patients at Risk/Exercise Prescription14.55

Behavior Change Outcome: Coping Self-Efficacy

"A psychometric questionnaire will assess coping self-efficacy using a likert scale at baseline and 6 weeks follow-up.~Coping Self-Efficacy: assesses an individuals belief in their ability to overcome barriers. Psychometric questionnaire assessing Coping Self-Efficacy was administered at baseline and follow-up. The psychometric questionnaire used a 5 point likert scale. (0 represents worst performance) to 45 (best performance)." (NCT01698463)
Timeframe: Baseline, 6 week follow-up

Interventionunits on a scale (Mean)
Identify Patients at Risk/Exercise Prescription34.45

Behavior Change Outcome: Intentions

"A psychometric questionnaire will assess intentions using a likert scale at baseline and 6 weeks follow-up.~Intentions: assesses an individuals intention to engage in recommended exercises. Psychometric questionnaire assessing Intentions was administered at baseline and follow-up. The psychometric questionnaire used a 5 point likert scale. (0 represents worst performance) to 15 (best performance)." (NCT01698463)
Timeframe: Baseline, 6 week follow-up

Interventionunits on a scale (Mean)
Identify Patients at Risk/Exercise Prescription12.0

Health Related Quality of Life (HRQOL)

The EQ-5D-5L questionnaire will be used to assess health related quality of life at baseline and at six weeks follow-up. The EQ-5D-5L questionnaire is very short and easy to complete making it ideal for a busy clinical setting. It consists of five questions which ask about pain, depression, activities, self-care and mobility. 0 (represents best performance) to 25 (represents worst performance). (NCT01698463)
Timeframe: Baseline, 6 week follow-up

Interventionunits on a scale (Mean)
Identify Patients at Risk/Exercise Prescription8.0

Physical Activity (Reporting Change in Physical Activity From Baseline to Six-week Follow-up)

The X2-Mini accelerometer (Gulf Coast Data Concepts.,USA) is a three-dimensional sensor that is used to capture the activity levels of an individual. The accelerometer is worn on the hip of the participant for four days. The number of minutes that the individual spends in each exercise intensity category is acquired. Accelerometer thresholds make up four categories of activity: (1) sedentary; (2) low-light; (3) high-light; (4) moderate-vigorous. Activity monitors have been indicated as the most accurate means of measuring physical activity levels. (NCT01698463)
Timeframe: Baseline, 6 week follow-up

Interventionminutes/day (Mean)
Identify Patients at Risk/Exercise Prescription21.6

Physical Activity (Self-report) (Reporting Change in Physical Activity From Baseline to Six-week Follow-up)

Participants complete a physical activity log book daily in order to document their completion of the prescribed exercises and list any additional activities that they may have been engaged in. The percentage of prescribed exercises completed are reported (for e.g. if participants completed 2 of 3 prescribed exercise then the reported percentage would be 67%). Mean (SD) are reported. (NCT01698463)
Timeframe: Baseline, 6 week follow-up

Interventionpercentage of completed exercise (Mean)
Identify Patients at Risk/Exercise Prescription65.7

Reviews

9 reviews available for caffeine and Osteoporosis

ArticleYear
Modifying nutritional risk factors.
    Aging clinical and experimental research, 2004, Volume: 16 Suppl, Issue:3

    Topics: Aluminum; Caffeine; Calcium, Dietary; Dietary Fats; Dietary Fiber; Dietary Proteins; Fractures, Bone

2004
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Drug-induced metabolic bone disease.
    Endocrinology and metabolism clinics of North America, 1995, Volume: 24, Issue:2

    Topics: Caffeine; Female; Glucocorticoids; Heparin; Humans; Hypothyroidism; Male; Middle Aged; Osteoporosis;

1995
[Caffeine intake and osteoporosis].
    Harefuah, 1999, Dec-01, Volume: 137, Issue:11

    Topics: Animals; Caffeine; Female; Humans; Osteoporosis; Osteoporosis, Postmenopausal

1999
[Epidemiology on bone mineral density among Japanese women].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 3

    Topics: Age Factors; Aged; Asian People; Bone Density; Caffeine; Exercise; Feeding Behavior; Female; Humans;

2002
Perspectives. Caffeine and bone: directions for research.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1991, Volume: 6, Issue:11

    Topics: Animals; Bone and Bones; Caffeine; Calcium; Female; Humans; Male; Osteoporosis; Rats; Risk Factors

1991
Profiles in osteoporosis.
    The American journal of nursing, 1991, Volume: 91, Issue:12

    Topics: Adult; Alcohol Drinking; Body Mass Index; Caffeine; Calcium, Dietary; Education, Nursing, Continuing

1991
Nutritional aspects of osteoporosis.
    World review of nutrition and dietetics, 1987, Volume: 49

    Topics: Caffeine; Calcium; Dietary Fiber; Dietary Proteins; Energy Intake; Ethanol; Fluorides; Humans; Lacto

1987
Nutrition: calcium, cholesterol, and calories.
    The Medical clinics of North America, 1987, Volume: 71, Issue:1

    Topics: Body Weight; Caffeine; Calcium, Dietary; Cholesterol, Dietary; Diet; Dietary Fats; Energy Intake; Et

1987

Other Studies

36 other studies available for caffeine and Osteoporosis

ArticleYear
The effects of caffeine on bone mineral density and fracture risk.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022, Volume: 33, Issue:6

    Topics: Adenosine; Adult; Bone Density; Caffeine; Coffee; Fractures, Bone; Humans; Osteoporosis

2022
Serum Metabolome of Coffee Consumption and its Association With Bone Mineral Density: The Hong Kong Osteoporosis Study.
    The Journal of clinical endocrinology and metabolism, 2020, 03-01, Volume: 105, Issue:3

    Topics: Absorptiometry, Photon; Alkaloids; Bone Density; Caffeine; Coffee; Diet Surveys; Drinking; Female; F

2020
The low-expression programming of 11β-HSD2 mediates osteoporosis susceptibility induced by prenatal caffeine exposure in male offspring rats.
    British journal of pharmacology, 2020, Volume: 177, Issue:20

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; 11-beta-Hydroxysteroid Dehydrogenases; Animals; Caffein

2020
Caffeine at a Moderate Dose Did Not Affect the Skeletal System of Rats with Streptozotocin-Induced Diabetes.
    Nutrients, 2017, Oct-30, Volume: 9, Issue:11

    Topics: Animals; Bone and Bones; Caffeine; Coffee; Diabetes Mellitus, Experimental; Dose-Response Relationsh

2017
β-Estradiol antagonizes the inhibitory effects of caffeine in BMMSCs via the ERβ-mediated cAMP-dependent PKA pathway.
    Toxicology, 2018, 02-01, Volume: 394

    Topics: Animals; Bone and Bones; Bone Marrow Cells; Caffeine; Cell Growth Processes; Cell Survival; Cells, C

2018
Intrauterine Programming of Glucocorticoid-Insulin-Like Growth Factor-1 Axis-Mediated Developmental Origin of Osteoporosis Susceptibility in Female Offspring Rats with Prenatal Caffeine Exposure.
    The American journal of pathology, 2018, Volume: 188, Issue:12

    Topics: Animals; Animals, Newborn; Caffeine; Cells, Cultured; Cellular Reprogramming; Central Nervous System

2018
Favorable effect of moderate dose caffeine on the skeletal system in ovariectomized rats.
    Molecular nutrition & food research, 2013, Volume: 57, Issue:10

    Topics: Animals; Bone Density; Caffeine; Calcification, Physiologic; Calcium; Cholesterol; Dose-Response Rel

2013
Long-term coffee consumption in relation to fracture risk and bone mineral density in women.
    American journal of epidemiology, 2013, Sep-15, Volume: 178, Issue:6

    Topics: Aged; Aged, 80 and over; Bone Density; Caffeine; Coffee; Female; Fractures, Bone; Humans; Longitudin

2013
METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2014, Volume: 29, Issue:7

    Topics: Animals; Caffeine; Calcium; Cell Count; Cell Death; Cell Differentiation; Cell Line; Dexamethasone;

2014
Dietary patterns and bone mineral density in Brazilian postmenopausal women with osteoporosis: a cross-sectional study.
    European journal of clinical nutrition, 2016, Volume: 70, Issue:1

    Topics: Absorptiometry, Photon; Aged; Beverages; Body Composition; Body Mass Index; Bone and Bones; Bone Den

2016
Levels of serum estradiol and lifestyle factors related with bone mineral density in premenopausal Mexican women: a cross-sectional analysis.
    BMC musculoskeletal disorders, 2016, 10-19, Volume: 17, Issue:1

    Topics: Absorptiometry, Photon; Adult; Age Factors; Body Mass Index; Bone Density; Caffeine; Calcium, Dietar

2016
Reciprocal roles between caffeine and estrogen on bone via differently regulating cAMP/PKA pathway: the possible mechanism for caffeine-induced osteoporosis in women and estrogen's antagonistic effects.
    Medical hypotheses, 2009, Volume: 73, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Est

2009
Effect of beer drinking on ultrasound bone mass in women.
    Nutrition (Burbank, Los Angeles County, Calif.), 2009, Volume: 25, Issue:10

    Topics: Adult; Aging; Alcohol Drinking; Analysis of Variance; Beer; Body Mass Index; Bone Density; Caffeine;

2009
Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2009, Sep-01, Volume: 181, Issue:5

    Topics: Age Factors; Aged; Caffeine; Canada; Central Nervous System Stimulants; Cohort Studies; Comorbidity;

2009
Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2009, Sep-01, Volume: 181, Issue:5

    Topics: Age Factors; Aged; Caffeine; Canada; Central Nervous System Stimulants; Cohort Studies; Comorbidity;

2009
Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2009, Sep-01, Volume: 181, Issue:5

    Topics: Age Factors; Aged; Caffeine; Canada; Central Nervous System Stimulants; Cohort Studies; Comorbidity;

2009
Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2009, Sep-01, Volume: 181, Issue:5

    Topics: Age Factors; Aged; Caffeine; Canada; Central Nervous System Stimulants; Cohort Studies; Comorbidity;

2009
Correlates of trabecular and cortical volumetric bone mineral density of the radius and tibia in older men: the Osteoporotic Fractures in Men Study.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010, Volume: 25, Issue:5

    Topics: Aged; Aged, 80 and over; Androgens; Bone and Bones; Bone Density; Caffeine; Diabetes Complications;

2010
Pilot case-control investigation of risk factors for hip fractures in the urban Indian population.
    BMC musculoskeletal disorders, 2010, Mar-14, Volume: 11

    Topics: Activities of Daily Living; Aged; Bone Diseases, Metabolic; Caffeine; Calcium, Dietary; Case-Control

2010
Risk factors of osteoporosis in healthy Moroccan men.
    BMC musculoskeletal disorders, 2010, Jul-05, Volume: 11

    Topics: Absorptiometry, Photon; Adult; Age Distribution; Aged; Aging; Body Mass Index; Body Weight; Bone Dis

2010
Caffeine inhibits the viability and osteogenic differentiation of rat bone marrow-derived mesenchymal stromal cells.
    British journal of pharmacology, 2010, Volume: 161, Issue:7

    Topics: Alkaline Phosphatase; Animals; Apoptosis; Bone Marrow Cells; Caffeine; Calcium; Cell Survival; Cells

2010
[Coffee can protect against disease].
    Ugeskrift for laeger, 2012, Sep-24, Volume: 174, Issue:39

    Topics: Alzheimer Disease; Anxiety; Caffeine; Cardiovascular Diseases; Coffee; Cognition; Diabetes Mellitus,

2012
Coffee: for most, it's safe. Coffee has been blamed for everything from moral turpitude to cancer. But none of the bad raps have stuck. Coffee may even be good for you.
    Harvard women's health watch, 2004, Volume: 12, Issue:1

    Topics: Caffeine; Cardiovascular System; Coffee; Diabetes Mellitus, Type 2; Female; Homocysteine; Humans; Li

2004
[Osteoporosis and beverage preference].
    Clinical calcium, 2005, Volume: 15, Issue:2

    Topics: Beverages; Caffeine; Female; Food Preferences; Humans; Osteoporosis

2005
Bone mineral density and serum 25-hydroxyvitamin D level: is there any difference according to the dressing style of the female university students.
    International journal of food sciences and nutrition, 2004, Volume: 55, Issue:7

    Topics: Adult; Animals; Bone Density; Caffeine; Calcium, Dietary; Cattle; Clothing; Female; Humans; Milk; Os

2004
Coffee, tea and caffeine consumption in relation to osteoporotic fracture risk in a cohort of Swedish women.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2006, Volume: 17, Issue:7

    Topics: Adult; Aged; Caffeine; Calcium; Calcium, Dietary; Coffee; Cohort Studies; Female; Hip Fractures; Hum

2006
A perception on health benefits of coffee.
    Critical reviews in food science and nutrition, 2008, Volume: 48, Issue:5

    Topics: Caffeine; Calcium; Cardiovascular Diseases; Central Nervous System Diseases; Coffee; Health Status;

2008
Nutritional factors and estrogen in age-related bone loss.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1982, Volume: 5, Issue:2-3

    Topics: Adult; Aged; Aging; Bone Resorption; Caffeine; Calcium; Calcium, Dietary; Dietary Proteins; Estrogen

1982
Caffeine and bone density loss.
    Epidemiology (Cambridge, Mass.), 1993, Volume: 4, Issue:6

    Topics: Bone Density; Caffeine; Calcium; Confounding Factors, Epidemiologic; Diet; Female; Humans; Massachus

1993
Coffee-associated osteoporosis offset by daily milk consumption. The Rancho Bernardo Study.
    JAMA, 1994, Jan-26, Volume: 271, Issue:4

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Animals; Bone Density; Caffeine; Coffee; Cohort Studi

1994
[Correlation between risk factors and bone mass in pre- and postmenopause. Epidemiologic study on osteoporosis (Part one)].
    Minerva medica, 1996, Volume: 87, Issue:9

    Topics: Adult; Aged; Alcohol Drinking; Body Weight; Bone Density; Breast Feeding; Caffeine; Calcium, Dietary

1996
Dietary caffeine intake and bone status of postmenopausal women.
    The American journal of clinical nutrition, 1997, Volume: 65, Issue:6

    Topics: Absorptiometry, Photon; Aged; Analysis of Variance; Anthropometry; Bone Density; Caffeine; Central N

1997
Stress fracture of the foot secondary to osteoporosis: an atypical presentation.
    Journal of the American Podiatric Medical Association, 2001, Volume: 91, Issue:2

    Topics: Adult; Caffeine; Female; Foot Bones; Fractures, Stress; Humans; Osteoporosis; Recurrence

2001
Is caffeine a risk factor for bone loss in the elderly?
    The American journal of clinical nutrition, 2001, Volume: 74, Issue:5

    Topics: Aged; Bone Density; Caffeine; Calcium; Calcium, Dietary; Female; Genotype; Humans; Menopause; Osteop

2001
[Methylxanthine-containing drugs and narcotics and osteoporosis].
    Orvosi hetilap, 1978, Jul-16, Volume: 119, Issue:29

    Topics: Animals; Caffeine; Calcitonin; Humans; Osteoporosis; Rats; Xanthines

1978
Is caffeine consumption a risk factor for osteoporosis?
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1992, Volume: 7, Issue:4

    Topics: Adult; Age Factors; Aged; Bone Density; Caffeine; Female; Humans; Middle Aged; Osteoporosis; Regress

1992
Caffeine and the risk of hip fracture: the Framingham Study.
    American journal of epidemiology, 1990, Volume: 132, Issue:4

    Topics: Age Factors; Aged; Aged, 80 and over; Caffeine; Calcium; Cohort Studies; Female; Hip Fractures; Huma

1990
From the National Institutes of Health.
    JAMA, 1989, Apr-07, Volume: 261, Issue:13

    Topics: Arthritis, Rheumatoid; Caffeine; Cyclosporins; Female; Fertility; Humans; Osteoporosis; Sodium Fluor

1989
NIH Consensus Conference: osteoporosis. Factors contributing to osteoporosis.
    The Journal of nutrition, 1986, Volume: 116, Issue:2

    Topics: Aged; Alcohol Drinking; Animals; Caffeine; Calcium; Calcium, Dietary; Diet; Drug-Related Side Effect

1986