caffeine has been researched along with Obsessive-Compulsive Disorder in 5 studies
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two small, double-blind, placebo-controlled, single-dose, crossover studies found dextroamphetamine (d-amphetamine) 30 mg clearly superior to placebo in relieving symptoms of obsessive-compulsive disorder (OCD)." | 9.14 | Double-blind study of dextroamphetamine versus caffeine augmentation for treatment-resistant obsessive-compulsive disorder. ( Aboujaoude, E; Gamel, NN; Koran, LM, 2009) |
| "Two small, double-blind, placebo-controlled, single-dose, crossover studies found dextroamphetamine (d-amphetamine) 30 mg clearly superior to placebo in relieving symptoms of obsessive-compulsive disorder (OCD)." | 5.14 | Double-blind study of dextroamphetamine versus caffeine augmentation for treatment-resistant obsessive-compulsive disorder. ( Aboujaoude, E; Gamel, NN; Koran, LM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mitra, S | 1 |
| Santana Miranda, V | 1 |
| McMillan, C | 1 |
| Dykes, D | 1 |
| Mucha, M | 1 |
| Marth, TE | 1 |
| Poe, B | 1 |
| Basu, DG | 1 |
| Bult-Ito, A | 1 |
| M Koran, L | 1 |
| Aboujaoude, E | 2 |
| Koran, LM | 1 |
| Gamel, NN | 1 |
| LUNDERQUIST, B | 1 |
| MacNeal, PS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind Trial of Acute and Intermediate-term Dextro-amphetamine Versus Caffeine Augmentation in Treatment Resistant Obsessive Compulsive Disorder (OCD)[NCT00363298] | 24 participants (Actual) | Interventional | 2006-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinical Global Impressions Scale Improvement Score = 1 (very much improved), or 2 (much improved). Additional possible scale scores are 3 (minimally improved), 4 (no change), 5 (minimally worse), 6 (much worse) and 7 (very much worse). (NCT00363298)
Timeframe: At end of week 5, except 1 d-amphetamine subject rated at end of week 2
| Intervention | participants (Number) |
|---|---|
| D-amphetamine | 6 |
| Caffeine Pills | 7 |
"Yale-Brown Obsessive-Compulsive Scale score by blinded investigator in direct interview. The scale score is the sum of ten items (5 for obsessions and 5 for compulsions: time occupied, degree of interference with functioning, degree of distress, effort to resist the symptom, success in resisting), each rated from 0 to 4, with higher scores indicating more severe OCD. Maximum score is 40. Scores of 14 and below are often described as subclinical, though patients with these scores may still exhibit troubling symptoms and mild to moderate distress. A total score of 8 or less is often termed remission. A decrease in total score from baseline to endpoint of either 25% or 35% is often used as a responder criterion in clinical trials." (NCT00363298)
Timeframe: At end of week 5, except 1 d-amphetamine subject rated at end of week 2
| Intervention | units on a scale (Mean) |
|---|---|
| D-amphetamine | 13.3 |
| Caffeine Pills | 13.0 |
1 review available for caffeine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Promising Treatments for Obsessive-Compulsive Disorder: A Call for Additional Research.
Topics: Caffeine; Cognitive Behavioral Therapy; Combined Modality Therapy; Humans; Ketamine; Memantine; Obse | 2018 |
1 trial available for caffeine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Double-blind study of dextroamphetamine versus caffeine augmentation for treatment-resistant obsessive-compulsive disorder.
Topics: Adult; Caffeine; Dextroamphetamine; Diagnostic and Statistical Manual of Mental Disorders; Double-Bl | 2009 |
3 other studies available for caffeine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Trait specific modulatory effects of caffeine exposure on compulsive-like behaviors in a spontaneous mouse model of obsessive-compulsive disorder.
Topics: Animals; Animals, Outbred Strains; Anxiety; Caffeine; Central Nervous System Stimulants; Disease Mod | 2020 |
[TRIAL OF SINEDYL WITH NEUROTIC PATIENTS IN GENERAL PRACTICE].
Topics: Anxiety; Anxiety Disorders; Atropa belladonna; Biomedical Research; Caffeine; General Practice; Huma | 1964 |
The patient with headache.
Topics: Age Factors; Alkaloids; Atropa belladonna; Caffeine; Diagnosis, Differential; Ergotamine; Headache; | 1967 |