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caffeine and Neural Tube Defects

caffeine has been researched along with Neural Tube Defects in 11 studies

Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)

Research Excerpts

ExcerptRelevanceReference
"Investigations of maternal caffeine intake and neural tube defects (NTDs) have not considered genetic influences."7.76Caffeine, selected metabolic gene variants, and risk for neural tube defects. ( Browne, ML; Burns, TL; Druschel, CM; Murray, JC; Olney, RS; Romitti, PA; Schmidt, RJ, 2010)
"Associations between maternal caffeine consumption and neural tube defects (NTDs) by type of NTD (anencephaly, spina bifida, or encephalocele) were examined using data from the National Birth Defects Prevention Study (NBDPS)."7.75Maternal caffeine consumption and risk of neural tube defects. ( Browne, ML; Burns, TL; Druschel, CM; Olney, RS; Romitti, PA; Schmidt, RJ, 2009)
"Alcohol and caffeine consumption during pregnancy are risk factors for fetal outcome."7.67Neural tube defects in early rat embryos following maternal treatment with ethanol and caffeine. ( Persaud, TV; Ross, CP, 1989)
" However, postimplantation embryo development assessed on Day 12 of gestation revealed that caffeine exposure of 15 and 30 mg kg(-1) significantly reduced, at both dosage levels, somite number and the extent of neural tube closure."5.30Maternal caffeine consumption during pregnancy does not affect preimplantation development but delays early postimplantation growth in rat embryos. ( Jacombs, A; Loupis, A; Pollard, I; Ryan, J, 1999)
"Investigations of maternal caffeine intake and neural tube defects (NTDs) have not considered genetic influences."3.76Caffeine, selected metabolic gene variants, and risk for neural tube defects. ( Browne, ML; Burns, TL; Druschel, CM; Murray, JC; Olney, RS; Romitti, PA; Schmidt, RJ, 2010)
"Associations between maternal caffeine consumption and neural tube defects (NTDs) by type of NTD (anencephaly, spina bifida, or encephalocele) were examined using data from the National Birth Defects Prevention Study (NBDPS)."3.75Maternal caffeine consumption and risk of neural tube defects. ( Browne, ML; Burns, TL; Druschel, CM; Olney, RS; Romitti, PA; Schmidt, RJ, 2009)
"Alcohol and caffeine consumption during pregnancy are risk factors for fetal outcome."3.67Neural tube defects in early rat embryos following maternal treatment with ethanol and caffeine. ( Persaud, TV; Ross, CP, 1989)
" However, postimplantation embryo development assessed on Day 12 of gestation revealed that caffeine exposure of 15 and 30 mg kg(-1) significantly reduced, at both dosage levels, somite number and the extent of neural tube closure."1.30Maternal caffeine consumption during pregnancy does not affect preimplantation development but delays early postimplantation growth in rat embryos. ( Jacombs, A; Loupis, A; Pollard, I; Ryan, J, 1999)
"Caffeine (25 mg/kg) was administered on gestation day (g."1.29In utero exposure to caffeine causes delayed neural tube closure in rat embryos. ( Pollard, I; Wilkinson, JM, 1994)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19905 (45.45)18.7374
1990's3 (27.27)18.2507
2000's1 (9.09)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schmidt, RJ2
Romitti, PA2
Burns, TL2
Browne, ML2
Druschel, CM2
Olney, RS2
Murray, JC1
Cavalli, P1
Cavallari, U1
Unfer, V1
Tonni, G1
Gilani, SH1
Giovinazzo, JJ1
Persaud, TV2
Renwick, JH1
Rosenberg, L1
Mitchell, AA1
Shapiro, S1
Slone, D1
Lee, H1
Nagele, RG1
Pietrolungo, JF1
Wilkinson, JM1
Pollard, I2
Marret, S1
Gressens, P1
Van-Maele-Fabry, G1
Picard, J1
Evrard, P1
Jacombs, A1
Ryan, J1
Loupis, A1
Ross, CP1

Trials

1 trial available for caffeine and Neural Tube Defects

ArticleYear
Selected birth defects in relation to caffeine-containing beverages.
    JAMA, 1982, Mar-12, Volume: 247, Issue:10

    Topics: Abnormalities, Drug-Induced; Beverages; Caffeine; Cleft Lip; Cleft Palate; Clinical Trials as Topic;

1982

Other Studies

10 other studies available for caffeine and Neural Tube Defects

ArticleYear
Maternal caffeine consumption and risk of neural tube defects.
    Birth defects research. Part A, Clinical and molecular teratology, 2009, Volume: 85, Issue:11

    Topics: Caffeine; Case-Control Studies; Female; Humans; Maternal Exposure; Neural Tube Defects; Pregnancy; R

2009
Caffeine, selected metabolic gene variants, and risk for neural tube defects.
    Birth defects research. Part A, Clinical and molecular teratology, 2010, Volume: 88, Issue:7

    Topics: Acetylation; Adolescent; Adult; Arylamine N-Acetyltransferase; Caffeine; Case-Control Studies; Cytoc

2010
Caffeine intake and risk of neural tube defects.
    Birth defects research. Part A, Clinical and molecular teratology, 2011, Volume: 91, Issue:1

    Topics: Caffeine; Female; Humans; Maternal Exposure; Neural Tube Defects; Pregnancy; Risk Factors

2011
Embryopathic effects of caffeine in the chick.
    Experimental pathology, 1983, Volume: 23, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chick Embryo; Hemorrhage; Intestines; Microphthalmos

1983
Food and malformation.
    The Practitioner, 1982, Volume: 226, Issue:1373

    Topics: Abnormalities, Drug-Induced; Caffeine; Congenital Abnormalities; Female; Fetal Alcohol Spectrum Diso

1982
Toxic and teratologic effects of caffeine on explanted early chick embryos.
    Teratology, 1982, Volume: 25, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Caffeine; Chick Embryo; Culture Techniques; Dose-Respon

1982
In utero exposure to caffeine causes delayed neural tube closure in rat embryos.
    Teratogenesis, carcinogenesis, and mutagenesis, 1994, Volume: 14, Issue:5

    Topics: Animals; Caffeine; Embryonic and Fetal Development; Female; Neural Tube Defects; Rats; Rats, Sprague

1994
Caffeine-induced disturbances of early neurogenesis in whole mouse embryo cultures.
    Brain research, 1997, Oct-31, Volume: 773, Issue:1-2

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Embryo, Mammalian; Embryonic and Fetal Development;

1997
Maternal caffeine consumption during pregnancy does not affect preimplantation development but delays early postimplantation growth in rat embryos.
    Reproduction, fertility, and development, 1999, Volume: 11, Issue:4-5

    Topics: Animals; Blastocyst; Caffeine; Embryonic and Fetal Development; Embryonic Development; Female; Fetal

1999
Neural tube defects in early rat embryos following maternal treatment with ethanol and caffeine.
    Anatomischer Anzeiger, 1989, Volume: 169, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Central Nervous System; Ethanol; Female; Neural Tube

1989