Page last updated: 2024-10-24

caffeine and Nausea

caffeine has been researched along with Nausea in 32 studies

Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to explore the relationships between nausea and vomiting in pregnancy and (a) fetal growth restriction; and (b) maternal caffeine metabolism and fetal growth restriction."7.79Does nausea and vomiting of pregnancy play a role in the association found between maternal caffeine intake and fetal growth restriction? ( Alwan, N; Boylan, SM; Cade, JE; Cooke, MS; Dolby, VA; Greenwood, DC; Hay, AW; Kirk, SF; Konje, JC; Potdar, N; Shires, S; Simpson, NA; Taub, N; Thomas, JD; Walker, JJ; White, KL; Wild, CP, 2013)
"Evidence for a harmful effect of caffeine intake on risk of miscarriage (spontaneous abortion) is inconsistent and nausea during pregnancy has been claimed to explain any association seen."7.72The effect of caffeine consumption and nausea on the risk of miscarriage. ( Doyle, P; Giannelli, M; Hermon, C; Pelerin, M; Roman, E, 2003)
"Signals of early pregnancy included an aversion to coffee in addition to nausea and vomiting, which resulted in decreased caffeine consumption."7.72Changes in caffeine consumption as a signal of pregnancy. ( Lawson, CC; LeMasters, GK; Wilson, KA, 2004)
" We analyzed data on 607 cases and 1,284 controls to evaluate the potential association between caffeine consumption during the first trimester of pregnancy and spontaneous abortion."7.68Caffeine consumption during pregnancy and spontaneous abortion. ( Eskenazi, B; Fenster, L; Swan, SH; Windham, GC, 1991)
"Ingestion of a combination of 5 mg x kg(-1) caffeine (C), and 1 mg x kg(-1) ephedrine (E) was reported to have an ergogenic effect on high intensity aerobic exercise performance, but 25% of the subjects experienced vomiting and nausea while engaging in hard exercise after the treatment."5.09Reducing the dose of combined caffeine and ephedrine preserves the ergogenic effect. ( Bell, DG; Jacobs, I; McLellan, TM; Zamecnik, J, 2000)
" Models accounted for women's age, BMI, employment, marital status, income, education, race, parity, prior losses, exercise and time-varying nausea/vomiting, caffeine, alcohol and smoking."4.12Prospectively assessed perceived stress associated with early pregnancy losses among women with history of pregnancy loss. ( Hinkle, SN; Kim, K; Mumford, SL; Plowden, TC; Purdue-Smithe, A; Schisterman, EF; Schliep, KC; Silver, RM; Sjaarda, LA; Stanford, JB, 2022)
"The aim of this study was to explore the relationships between nausea and vomiting in pregnancy and (a) fetal growth restriction; and (b) maternal caffeine metabolism and fetal growth restriction."3.79Does nausea and vomiting of pregnancy play a role in the association found between maternal caffeine intake and fetal growth restriction? ( Alwan, N; Boylan, SM; Cade, JE; Cooke, MS; Dolby, VA; Greenwood, DC; Hay, AW; Kirk, SF; Konje, JC; Potdar, N; Shires, S; Simpson, NA; Taub, N; Thomas, JD; Walker, JJ; White, KL; Wild, CP, 2013)
"Evidence for a harmful effect of caffeine intake on risk of miscarriage (spontaneous abortion) is inconsistent and nausea during pregnancy has been claimed to explain any association seen."3.72The effect of caffeine consumption and nausea on the risk of miscarriage. ( Doyle, P; Giannelli, M; Hermon, C; Pelerin, M; Roman, E, 2003)
"Signals of early pregnancy included an aversion to coffee in addition to nausea and vomiting, which resulted in decreased caffeine consumption."3.72Changes in caffeine consumption as a signal of pregnancy. ( Lawson, CC; LeMasters, GK; Wilson, KA, 2004)
" We analyzed data on 607 cases and 1,284 controls to evaluate the potential association between caffeine consumption during the first trimester of pregnancy and spontaneous abortion."3.68Caffeine consumption during pregnancy and spontaneous abortion. ( Eskenazi, B; Fenster, L; Swan, SH; Windham, GC, 1991)
"Treatment with almotriptan was associated with a significantly greater proportion of patients achieving 2-h pain free (20."2.73Crossover, double-blind clinical trial comparing almotriptan and ergotamine plus caffeine for acute migraine therapy. ( Galván, J; Heras, J; Láinez, MJ; Vila, C, 2007)
"Both caffeine and orthostasis have known cardiovascular effects."2.71The effect of caffeine on the cardiovascular responses to head-up tilt. ( Berry, NM; Newman, DG; Rickards, CA, 2003)
"Most people who experience migraine use OTC medications to treat their symptoms, but no head-to-head clinical trials comparing these agents with prescription migraine therapies have been published."2.71Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial. ( Baggish, J; Battikha, JP; Elkind, AH; Gallagher, RM; Goldstein, J; Hoffman, H; Saper, JR; Silberstein, SD; Smith, TR, 2005)
" The global incidence of adverse events was 45% higher with EC, though not significant (32 vs."2.69Comparative efficacy and safety of calcium carbasalate plus metoclopramide versus ergotamine tartrate plus caffeine in the treatment of acute migraine attacks. ( Geraud, G; Gómez, JP; Henry, P; Joffroy, A; Lainez, JM; Le Jeunne, C; Liaño, H; Pradalier, A; Titus i Albareda, F, 1999)
"Sumatriptan was significantly more effective than Cafergot at reducing the intensity of headache from severe or moderate to mild or none; 66% (145/220) of those treated with sumatriptan improved in this way by 2 h, compared with 48% (118/246) of those treated with Cafergot (p less than 0."2.67A randomized, double-blind comparison of sumatriptan and Cafergot in the acute treatment of migraine. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group. ( , 1991)
"An analysis of calls to three poison centers for powdered caffeine found that exposures were uncommon, but did result in toxicity, and highlighted that the lack of clear dosing instructions on product packaging may place patients at risk of inadvertent overdose."1.43A Retrospective Study of Clinical Effects of Powdered Caffeine Exposures Reported to Three US Poison Control Centers. ( Beauchamp, GA; Crouch, BI; Hendrickson, RG; Horowitz, BZ; Johnson, AR; Valento, M, 2016)
"Effects of binge drinking on GI symptoms were strongest when comparing between individuals (rather than within individuals)."1.39Relationship between patterns of alcohol consumption and gastrointestinal symptoms among patients with irritable bowel syndrome. ( Cain, KC; Eugenio, MD; Heitkemper, MM; Jarrett, ME; Reding, KW, 2013)
"Migraine is one of the most common disorders seen in paediatric neurological practice."1.26Migraine and migraine equivalents in children. ( Brown, JK, 1977)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19904 (12.50)18.7374
1990's10 (31.25)18.2507
2000's12 (37.50)29.6817
2010's5 (15.63)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Schliep, KC1
Hinkle, SN1
Kim, K1
Sjaarda, LA1
Silver, RM1
Stanford, JB1
Purdue-Smithe, A1
Plowden, TC1
Schisterman, EF1
Mumford, SL1
Wilson, PB1
Beauchamp, GA1
Johnson, AR1
Crouch, BI1
Valento, M1
Horowitz, BZ1
Hendrickson, RG1
Boylan, SM1
Greenwood, DC1
Alwan, N1
Cooke, MS1
Dolby, VA1
Hay, AW1
Kirk, SF1
Konje, JC1
Potdar, N1
Shires, S1
Simpson, NA1
Taub, N1
Thomas, JD1
Walker, JJ1
White, KL1
Wild, CP1
Cade, JE1
Reding, KW1
Cain, KC1
Jarrett, ME1
Eugenio, MD1
Heitkemper, MM1
Iglesias-Lepine, ML1
Epelde, F1
Espinosa, J1
Mariñosa, M1
Lawson, CC2
LeMasters, GK2
Levin, LS1
Liu, JH1
Berry, NM1
Rickards, CA1
Newman, DG1
Giannelli, M1
Doyle, P1
Roman, E1
Pelerin, M1
Hermon, C1
Wilson, KA1
Jessen, A1
Buemann, B1
Toubro, S1
Skovgaard, IM1
Astrup, A1
Goldstein, J2
Silberstein, SD1
Saper, JR1
Elkind, AH1
Smith, TR1
Gallagher, RM1
Battikha, JP2
Hoffman, H1
Baggish, J1
George, L1
Granath, F2
Johansson, AL1
Annerén, G2
Cnattingius, S2
Láinez, MJ1
Galván, J1
Heras, J1
Vila, C1
Beine, S1
Verwied, SC1
Lührmann, PM1
Kolasa, KM1
Weismiller, DG1
Le Jeunne, C1
Gómez, JP1
Pradalier, A1
Titus i Albareda, F1
Joffroy, A1
Liaño, H1
Henry, P1
Lainez, JM1
Geraud, G1
Biederman, GB1
Davey, VA1
Hoffman, HD1
Armellino, JJ1
Hamelsky, SW1
Couch, J1
Blumenthal, H1
Lipton, RB1
Bell, DG1
Jacobs, I1
McLellan, TM1
Zamecnik, J1
Signorello, LB1
Clausson, B1
Ekbom, A1
Ljunger, E1
Blot, WJ1
McLaughlin, JK1
Petersson, G1
Rane, A1
Wen, W1
Shu, XO1
Jacobs, DR1
Brown, JE1
Furneaux, EC1
Langley-Evans, AJ1
Langley-Evans, SC1
Brown, JK1
Saxena, VK1
De Deyn, PP1
Fenster, L2
Windham, GC2
Swan, SH2
Eskenazi, B2
Stein, Z1
Susser, M1
Smits, P1
Schouten, J1
Thien, T1
Weintraub, SJ1
Naulty, JS1
Grawitz, PB1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.[NCT00467363]1,228 participants (Actual)Interventional2007-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Abruption

Partial or complete abruption (ie, premature separation of the placenta) (NCT00467363)
Timeframe: until delivery

Interventionparticipants (Number)
Aspirin7
Placebo5

Clinically Recognized Pregnancy

(NCT00467363)
Timeframe: 8-weeks

Interventionpregnancy (Number)
Aspirin374
Placebo346

Early Pregnancy Loss (EPL)

Implantation failures (NCT00467363)
Timeframe: 8 weeks

Interventionpregnancy (Number)
Aspirin28
Placebo27

Ectopic Pregnancy

(NCT00467363)
Timeframe: within 6 weeks

Interventionpregnancy (Number)
Aspirin3
Placebo3

Fetal Pregnancy Loss

(NCT00467363)
Timeframe: until 40 weeks

Interventionpregnancy (Number)
Aspirin4
Placebo6

hCG Recognized Pregnancy

(NCT00467363)
Timeframe: within 8-weeks of gestation

Interventionpregnancy (Number)
Aspirin394
Placebo363

Live Birth

Live birth was obtained prospectively by maternal report and abstraction from medical records by trained staff . (NCT00467363)
Timeframe: after delivery

Interventionlivebirths (Number)
Aspirin309
Placebo286

Molar Pregnancy

(NCT00467363)
Timeframe: 8 weeks

Interventionpregnancy (Number)
Aspirin0
Placebo0

Preeclampsia

(NCT00467363)
Timeframe: until delivery

Interventionparticipants (Number)
Aspirin32
Placebo30

Pregnancy Losses Occurring Less Than 10 Weeks

Includes preembryonic and embryonic losses (exclusive of implantation failures) (NCT00467363)
Timeframe: less than 10-weeks

Interventionpregnancy (Number)
Aspirin56
Placebo53

Preterm Birth

(NCT00467363)
Timeframe: until delivery

Interventioninfants (Number)
Aspirin22
Placebo31

Small for Gestational Age Infant

birthweight (NCT00467363)
Timeframe: until delivery

Interventiongrams (Mean)
Aspirin3327
Placebo3315

Stillbirth

(NCT00467363)
Timeframe: 40 weeks

Interventionparticipants (Number)
Aspirin2
Placebo2

Reviews

3 reviews available for caffeine and Nausea

ArticleYear
Nutrition during pregnancy.
    American family physician, 1997, Volume: 56, Issue:1

    Topics: Caffeine; Constipation; Female; Humans; Lactose Intolerance; Nausea; Nutrition Assessment; Nutrition

1997
Nausea and vomiting of pregnancy: endocrine basis and contribution to pregnancy outcome.
    Obstetrical & gynecological survey, 2001, Volume: 56, Issue:12

    Topics: Abortion, Spontaneous; Alcohol Drinking; Caffeine; Chorionic Gonadotropin; Congenital Abnormalities;

2001
Ergotamine: its use in the treatment of migraine and its complications.
    Acta neurologica, 1992, Volume: 14, Issue:2

    Topics: Autonomic Nervous System Diseases; Caffeine; Cardiovascular Diseases; Contraindications; Drug Admini

1992

Trials

10 trials available for caffeine and Nausea

ArticleYear
The effect of caffeine on the cardiovascular responses to head-up tilt.
    Aviation, space, and environmental medicine, 2003, Volume: 74, Issue:7

    Topics: Adult; Blood Pressure; Caffeine; Cardiovascular Physiological Phenomena; Dizziness; Female; Heart Ra

2003
The appetite-suppressant effect of nicotine is enhanced by caffeine.
    Diabetes, obesity & metabolism, 2005, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Appetite; Appetite Depressants; Caffeine; Chewing Gum; Double-Blind Method; Drug

2005
Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial.
    Headache, 2005, Volume: 45, Issue:8

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-

2005
Crossover, double-blind clinical trial comparing almotriptan and ergotamine plus caffeine for acute migraine therapy.
    European journal of neurology, 2007, Volume: 14, Issue:3

    Topics: Acute Disease; Adult; Caffeine; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination;

2007
Coffee consumption and total body water homeostasis as measured by fluid balance and bioelectrical impedance analysis.
    Annals of nutrition & metabolism, 1997, Volume: 41, Issue:1

    Topics: Adult; Blood Circulation; Body Water; Body Weight; Caffeine; Coffee; Diuresis; Female; Headache; Hom

1997
Comparative efficacy and safety of calcium carbasalate plus metoclopramide versus ergotamine tartrate plus caffeine in the treatment of acute migraine attacks.
    European neurology, 1999, Volume: 41, Issue:1

    Topics: Abdominal Pain; Adolescent; Adult; Aged; Analgesics; Aspirin; Caffeine; Double-Blind Method; Drug Th

1999
Treatment of severe, disabling migraine attacks in an over-the-counter population of migraine sufferers: results from three randomized, placebo-controlled studies of the combination of acetaminophen, aspirin, and caffeine.
    Cephalalgia : an international journal of headache, 1999, Volume: 19, Issue:7

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Caffeine; Double-Blind Method; D

1999
Reducing the dose of combined caffeine and ephedrine preserves the ergogenic effect.
    Aviation, space, and environmental medicine, 2000, Volume: 71, Issue:4

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Drug Combinations; Ephedrin

2000
A randomized, double-blind comparison of sumatriptan and Cafergot in the acute treatment of migraine. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group.
    European neurology, 1991, Volume: 31, Issue:5

    Topics: Administration, Oral; Adult; Aged; Caffeine; Double-Blind Method; Drug Combinations; Electrocardiogr

1991
Cardiovascular effects of two xanthines and the relation to adenosine antagonism.
    Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:6

    Topics: Adenosine; Adult; Aldosterone; Blood Pressure; Caffeine; Double-Blind Method; Epinephrine; Female; H

1989

Other Studies

19 other studies available for caffeine and Nausea

ArticleYear
Prospectively assessed perceived stress associated with early pregnancy losses among women with history of pregnancy loss.
    Human reproduction (Oxford, England), 2022, 09-30, Volume: 37, Issue:10

    Topics: Abortion, Spontaneous; Biomarkers; Caffeine; Child; Female; Humans; Nausea; Pregnancy; Stress, Psych

2022
Dietary and non-dietary correlates of gastrointestinal distress during the cycle and run of a triathlon.
    European journal of sport science, 2016, Volume: 16, Issue:4

    Topics: Abdominal Pain; Adult; Caffeine; Diet; Dietary Carbohydrates; Energy Intake; Female; Flatulence; Gas

2016
A Retrospective Study of Clinical Effects of Powdered Caffeine Exposures Reported to Three US Poison Control Centers.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:3

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Child; Combined Modality Therapy; Dietary Supple

2016
Does nausea and vomiting of pregnancy play a role in the association found between maternal caffeine intake and fetal growth restriction?
    Maternal and child health journal, 2013, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Caffeine; Female; Fetal Development; Fetal Growth Retardation; Gestational Age; H

2013
Relationship between patterns of alcohol consumption and gastrointestinal symptoms among patients with irritable bowel syndrome.
    The American journal of gastroenterology, 2013, Volume: 108, Issue:2

    Topics: Abdominal Pain; Adult; Alcohol Drinking; Binge Drinking; Caffeine; Case-Control Studies; Coffee; Con

2013
[Consumption of energy drinks with alcohol, hazardous mixture].
    Medicina clinica, 2013, Aug-04, Volume: 141, Issue:3

    Topics: Adolescent; Alcoholic Beverages; Caffeine; Catecholamines; Dose-Response Relationship, Drug; Drug Sy

2013
Pregnancy hormone metabolite patterns, pregnancy symptoms, and coffee consumption.
    American journal of epidemiology, 2002, Sep-01, Volume: 156, Issue:5

    Topics: Adult; Caffeine; Chorionic Gonadotropin; Coffee; Estrone; Female; Humans; Nausea; Pregnancy; Pregnan

2002
The effect of caffeine consumption and nausea on the risk of miscarriage.
    Paediatric and perinatal epidemiology, 2003, Volume: 17, Issue:4

    Topics: Abortion, Spontaneous; Adult; Beverages; Caffeine; Case-Control Studies; Coffee; Dose-Response Relat

2003
Changes in caffeine consumption as a signal of pregnancy.
    Reproductive toxicology (Elmsford, N.Y.), 2004, Volume: 18, Issue:5

    Topics: Adolescent; Adult; Asian People; Black or African American; Caffeine; Chorionic Gonadotropin; Coffee

2004
Environmental tobacco smoke and risk of spontaneous abortion.
    Epidemiology (Cambridge, Mass.), 2006, Volume: 17, Issue:5

    Topics: Abortion, Spontaneous; Adult; Biomarkers; Caffeine; Case-Control Studies; Chromosome Aberrations; Co

2006
Alleviating nausea and emesis by Pavlovian conditioning.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1999, May-04, Volume: 160, Issue:9

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Conditioning, Classical; Dose-Response Relatio

1999
Caffeine intake and the risk of first-trimester spontaneous abortion.
    The New England journal of medicine, 2000, Dec-21, Volume: 343, Issue:25

    Topics: Abortion, Spontaneous; Adolescent; Adult; Caffeine; Case-Control Studies; Chromosome Aberrations; Ch

2000
The associations of maternal caffeine consumption and nausea with spontaneous abortion.
    Epidemiology (Cambridge, Mass.), 2001, Volume: 12, Issue:1

    Topics: Abortion, Spontaneous; Adult; Caffeine; Female; Humans; Minnesota; Nausea; Odds Ratio; Pregnancy; Pr

2001
Migraine and migraine equivalents in children.
    Developmental medicine and child neurology, 1977, Volume: 19, Issue:5

    Topics: Caffeine; Capillary Permeability; Cerebrovascular Circulation; Child; Diagnosis, Differential; Epile

1977
Miscarriage, caffeine, and the epiphenomena of pregnancy: the causal model.
    Epidemiology (Cambridge, Mass.), 1991, Volume: 2, Issue:4

    Topics: Abortion, Spontaneous; Caffeine; Female; Humans; Nausea; Pregnancy; Pregnancy Complications

1991
Miscarriage, caffeine, and the epiphenomena of pregnancy: the causal model.
    Epidemiology (Cambridge, Mass.), 1991, Volume: 2, Issue:3

    Topics: Abortion, Spontaneous; Beverages; Caffeine; Female; Humans; Nausea; Pregnancy; Pregnancy Complicatio

1991
Caffeine consumption during pregnancy and spontaneous abortion.
    Epidemiology (Cambridge, Mass.), 1991, Volume: 2, Issue:3

    Topics: Abortion, Spontaneous; Adult; Beverages; Caffeine; California; Case-Control Studies; Demography; Fem

1991
Acute abstinence syndrome after epidural injection of butorphanol.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:4

    Topics: Adult; Anesthesia, Epidural; Aspirin; Blood Pressure; Butorphanol; Caffeine; Cesarean Section; Codei

1985
[Prophylaxis and therapy of the mountain sickness, puna].
    Schweizerische medizinische Wochenschrift, 1971, May-08, Volume: 101, Issue:18

    Topics: Altitude; Caffeine; Ergotamine; Headache; Humans; Hypoxia; Nausea; Oxygen Inhalation Therapy; Physic

1971