Page last updated: 2024-10-24

caffeine and Narcolepsy

caffeine has been researched along with Narcolepsy in 11 studies

Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)

Research Excerpts

ExcerptRelevanceReference
"The effects of caffeine on drowsiness and reaction time in patients with narcolepsy are unclear."9.34The effects of caffeine on drowsiness in patients with narcolepsy: a double-blind randomized controlled pilot study. ( Abulmeaty, MMA; Aldosari, MS; BaHammam, AS; Nashwan, SZ; Olaish, AH, 2020)
"The effects of caffeine on drowsiness and reaction time in patients with narcolepsy are unclear."5.34The effects of caffeine on drowsiness in patients with narcolepsy: a double-blind randomized controlled pilot study. ( Abulmeaty, MMA; Aldosari, MS; BaHammam, AS; Nashwan, SZ; Olaish, AH, 2020)
"We evaluated the wake-promoting efficacy of paraxanthine, caffeine, and a reference wake-promoting compound, modafinil, in a mice model of narcolepsy, a prototypical disease model of hypersomnia."3.76Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice. ( Fujiki, N; Ishimaru, Y; Kotorii, N; Nishino, S; Okuro, M; Sokoloff, P, 2010)
"Narcolepsy is a neurodegenerative disorder resulting in the instability of the sleep-wake cycle and marked by low levels of hypocretin in cerebrospinal fluid."2.46Expert opinion on pharmacotherapy of narcolepsy. ( Dimitriu, A; Guilleminault, C; Zaharna, M, 2010)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19903 (27.27)18.7374
1990's2 (18.18)18.2507
2000's1 (9.09)29.6817
2010's4 (36.36)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Aldosari, MS1
Olaish, AH1
Nashwan, SZ1
Abulmeaty, MMA1
BaHammam, AS1
Zaharna, M1
Dimitriu, A1
Guilleminault, C1
Okuro, M1
Fujiki, N1
Kotorii, N1
Ishimaru, Y1
Sokoloff, P1
Nishino, S2
Ton, TG1
Watson, NF1
Longstreth, WT1
Heatherley, SV1
Garma, L1
Marchand, F1
Manber, R1
Bootzin, RR1
Acebo, C1
Carskadon, MA1
Wisor, JP1
Sora, I1
Uhl, GH1
Mignot, E1
Edgar, DM1
Kaneko, Y1
Takahashi, Y1
Kaneko, M1
Kumashiro, H1
Sigwald, J1
Julou, L1
Bouttier, D1
Thomas, J1
Alberti, KG1
Hockaday, TD1
Williamson, DH1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial[NCT02832336]Phase 1/Phase 216 participants (Actual)Interventional2016-10-01Completed
A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102]Phase 4105 participants (Actual)Interventional2016-02-29Terminated
Modafinil Treatment for Sleep/Wake Disturbances in Older Adults[NCT00626210]Phase 42 participants (Actual)Interventional2008-02-29Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit

Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours

Interventionminutes (Mean)
Placebo53.5
Modafinil61.0

Postanesthesia Quality Recovery Scale Score

Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery

Interventionunits on a scale (Mean)
Placebo-5.67
Modafinil-8.91

Nocturnal Sleep Length at 1 Month

(NCT00626210)
Timeframe: 1 month

Interventionhours (Median)
Modafinil9.5

Reviews

2 reviews available for caffeine and Narcolepsy

ArticleYear
Expert opinion on pharmacotherapy of narcolepsy.
    Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:10

    Topics: Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants;

2010
Caffeine withdrawal, sleepiness, and driving performance: what does the research really tell us?
    Nutritional neuroscience, 2011, Volume: 14, Issue:3

    Topics: Attention; Automobile Driving; Caffeine; Central Nervous System Stimulants; Humans; Narcolepsy; Reac

2011

Trials

1 trial available for caffeine and Narcolepsy

ArticleYear
The effects of caffeine on drowsiness in patients with narcolepsy: a double-blind randomized controlled pilot study.
    Sleep & breathing = Schlaf & Atmung, 2020, Volume: 24, Issue:4

    Topics: Adult; Caffeine; Double-Blind Method; Humans; Male; Narcolepsy; Pilot Projects; Treatment Outcome; Y

2020

Other Studies

8 other studies available for caffeine and Narcolepsy

ArticleYear
Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice.
    Sleep, 2010, Volume: 33, Issue:7

    Topics: Animals; Ataxin-3; Benzhydryl Compounds; Body Temperature; Caffeine; Central Nervous System Stimulan

2010
Associations between narcolepsy and consumption of alcohol and caffeinated beverages among genetically susceptible individuals: a population-based case-control study.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2010, Aug-15, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Age Factors; Age of Onset; Alcohol Drinking; Beverages; Caffeine; Case-Control St

2010
Non-pharmacological approaches to the treatment of narcolepsy.
    Sleep, 1994, Volume: 17, Issue:8 Suppl

    Topics: Adolescent; Adult; Caffeine; Circadian Rhythm; Employment; Feeding Behavior; Female; Humans; Hypnosi

1994
The effects of regularizing sleep-wake schedules on daytime sleepiness.
    Sleep, 1996, Volume: 19, Issue:5

    Topics: Adolescent; Adult; Caffeine; Female; Humans; Light; Longitudinal Studies; Male; Narcolepsy; Prospect

1996
Dopaminergic role in stimulant-induced wakefulness.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Mar-01, Volume: 21, Issue:5

    Topics: Amphetamine; Animals; Benzhydryl Compounds; Caffeine; Carrier Proteins; Caudate Nucleus; Central Ner

2001
Dopaminergic role in stimulant-induced wakefulness.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Mar-01, Volume: 21, Issue:5

    Topics: Amphetamine; Animals; Benzhydryl Compounds; Caffeine; Carrier Proteins; Caudate Nucleus; Central Ner

2001
Dopaminergic role in stimulant-induced wakefulness.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Mar-01, Volume: 21, Issue:5

    Topics: Amphetamine; Animals; Benzhydryl Compounds; Caffeine; Carrier Proteins; Caudate Nucleus; Central Ner

2001
Dopaminergic role in stimulant-induced wakefulness.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Mar-01, Volume: 21, Issue:5

    Topics: Amphetamine; Animals; Benzhydryl Compounds; Caffeine; Carrier Proteins; Caudate Nucleus; Central Ner

2001
Therapeutic usefulness of ergotamine tartrate for narcolepsy.
    The American journal of psychiatry, 1978, Volume: 135, Issue:7

    Topics: Adult; Caffeine; Drug Combinations; Ergotamine; Humans; Male; Narcolepsy; Phenobarbital

1978
[Therapy of hypersomnia].
    Revue neurologique, 1967, Volume: 116, Issue:6

    Topics: Amphetamine; Animals; Antidepressive Agents; Appetite Depressants; Bemegride; Caffeine; Cats; Centra

1967
Metabolic effects of chronic caffeine administration in a patient with diabetes mellitus.
    Proceedings of the Royal Society of Medicine, 1972, Volume: 65, Issue:5

    Topics: Caffeine; Diabetes Mellitus; Fatty Acids, Nonesterified; Humans; Hyperglycemia; Ketone Bodies; Male;

1972