caffeine has been researched along with Narcolepsy in 11 studies
Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of caffeine on drowsiness and reaction time in patients with narcolepsy are unclear." | 9.34 | The effects of caffeine on drowsiness in patients with narcolepsy: a double-blind randomized controlled pilot study. ( Abulmeaty, MMA; Aldosari, MS; BaHammam, AS; Nashwan, SZ; Olaish, AH, 2020) |
| "The effects of caffeine on drowsiness and reaction time in patients with narcolepsy are unclear." | 5.34 | The effects of caffeine on drowsiness in patients with narcolepsy: a double-blind randomized controlled pilot study. ( Abulmeaty, MMA; Aldosari, MS; BaHammam, AS; Nashwan, SZ; Olaish, AH, 2020) |
| "We evaluated the wake-promoting efficacy of paraxanthine, caffeine, and a reference wake-promoting compound, modafinil, in a mice model of narcolepsy, a prototypical disease model of hypersomnia." | 3.76 | Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice. ( Fujiki, N; Ishimaru, Y; Kotorii, N; Nishino, S; Okuro, M; Sokoloff, P, 2010) |
| "Narcolepsy is a neurodegenerative disorder resulting in the instability of the sleep-wake cycle and marked by low levels of hypocretin in cerebrospinal fluid." | 2.46 | Expert opinion on pharmacotherapy of narcolepsy. ( Dimitriu, A; Guilleminault, C; Zaharna, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Aldosari, MS | 1 |
| Olaish, AH | 1 |
| Nashwan, SZ | 1 |
| Abulmeaty, MMA | 1 |
| BaHammam, AS | 1 |
| Zaharna, M | 1 |
| Dimitriu, A | 1 |
| Guilleminault, C | 1 |
| Okuro, M | 1 |
| Fujiki, N | 1 |
| Kotorii, N | 1 |
| Ishimaru, Y | 1 |
| Sokoloff, P | 1 |
| Nishino, S | 2 |
| Ton, TG | 1 |
| Watson, NF | 1 |
| Longstreth, WT | 1 |
| Heatherley, SV | 1 |
| Garma, L | 1 |
| Marchand, F | 1 |
| Manber, R | 1 |
| Bootzin, RR | 1 |
| Acebo, C | 1 |
| Carskadon, MA | 1 |
| Wisor, JP | 1 |
| Sora, I | 1 |
| Uhl, GH | 1 |
| Mignot, E | 1 |
| Edgar, DM | 1 |
| Kaneko, Y | 1 |
| Takahashi, Y | 1 |
| Kaneko, M | 1 |
| Kumashiro, H | 1 |
| Sigwald, J | 1 |
| Julou, L | 1 |
| Bouttier, D | 1 |
| Thomas, J | 1 |
| Alberti, KG | 1 |
| Hockaday, TD | 1 |
| Williamson, DH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial[NCT02832336] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2016-10-01 | Completed | ||
| A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102] | Phase 4 | 105 participants (Actual) | Interventional | 2016-02-29 | Terminated | ||
| Modafinil Treatment for Sleep/Wake Disturbances in Older Adults[NCT00626210] | Phase 4 | 2 participants (Actual) | Interventional | 2008-02-29 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Placebo | 53.5 |
| Modafinil | 61.0 |
Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -5.67 |
| Modafinil | -8.91 |
(NCT00626210)
Timeframe: 1 month
| Intervention | hours (Median) |
|---|---|
| Modafinil | 9.5 |
2 reviews available for caffeine and Narcolepsy
| Article | Year |
|---|---|
Expert opinion on pharmacotherapy of narcolepsy.
Topics: Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; | 2010 |
Caffeine withdrawal, sleepiness, and driving performance: what does the research really tell us?
Topics: Attention; Automobile Driving; Caffeine; Central Nervous System Stimulants; Humans; Narcolepsy; Reac | 2011 |
1 trial available for caffeine and Narcolepsy
| Article | Year |
|---|---|
The effects of caffeine on drowsiness in patients with narcolepsy: a double-blind randomized controlled pilot study.
Topics: Adult; Caffeine; Double-Blind Method; Humans; Male; Narcolepsy; Pilot Projects; Treatment Outcome; Y | 2020 |
8 other studies available for caffeine and Narcolepsy
| Article | Year |
|---|---|
Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice.
Topics: Animals; Ataxin-3; Benzhydryl Compounds; Body Temperature; Caffeine; Central Nervous System Stimulan | 2010 |
Associations between narcolepsy and consumption of alcohol and caffeinated beverages among genetically susceptible individuals: a population-based case-control study.
Topics: Adolescent; Adult; Age Factors; Age of Onset; Alcohol Drinking; Beverages; Caffeine; Case-Control St | 2010 |
Non-pharmacological approaches to the treatment of narcolepsy.
Topics: Adolescent; Adult; Caffeine; Circadian Rhythm; Employment; Feeding Behavior; Female; Humans; Hypnosi | 1994 |
The effects of regularizing sleep-wake schedules on daytime sleepiness.
Topics: Adolescent; Adult; Caffeine; Female; Humans; Light; Longitudinal Studies; Male; Narcolepsy; Prospect | 1996 |
Dopaminergic role in stimulant-induced wakefulness.
Topics: Amphetamine; Animals; Benzhydryl Compounds; Caffeine; Carrier Proteins; Caudate Nucleus; Central Ner | 2001 |
Dopaminergic role in stimulant-induced wakefulness.
Topics: Amphetamine; Animals; Benzhydryl Compounds; Caffeine; Carrier Proteins; Caudate Nucleus; Central Ner | 2001 |
Dopaminergic role in stimulant-induced wakefulness.
Topics: Amphetamine; Animals; Benzhydryl Compounds; Caffeine; Carrier Proteins; Caudate Nucleus; Central Ner | 2001 |
Dopaminergic role in stimulant-induced wakefulness.
Topics: Amphetamine; Animals; Benzhydryl Compounds; Caffeine; Carrier Proteins; Caudate Nucleus; Central Ner | 2001 |
Therapeutic usefulness of ergotamine tartrate for narcolepsy.
Topics: Adult; Caffeine; Drug Combinations; Ergotamine; Humans; Male; Narcolepsy; Phenobarbital | 1978 |
[Therapy of hypersomnia].
Topics: Amphetamine; Animals; Antidepressive Agents; Appetite Depressants; Bemegride; Caffeine; Cats; Centra | 1967 |
Metabolic effects of chronic caffeine administration in a patient with diabetes mellitus.
Topics: Caffeine; Diabetes Mellitus; Fatty Acids, Nonesterified; Humans; Hyperglycemia; Ketone Bodies; Male; | 1972 |