caffeine and Muscle Contraction studies

Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Research Excerpts

Excerpt	Relevance	Reference
" kg(-1) body weight dose of caffeine on delayed-onset muscle pain intensity and force loss in response to 64 eccentric actions of the dominant quadriceps induced by electrical stimulation."	9.12	Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise. ( Dudley, GA; Maridakis, V; McCully, KK; O'Connor, PJ, 2007)
"This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain and blood pressure during moderate intensity cycling exercise."	9.11	Dose-dependent effect of caffeine on reducing leg muscle pain during cycling exercise is unrelated to systolic blood pressure. ( Broglio, SP; Ely, MR; Motl, RW; O'Connor, PJ, 2004)
"In this experiment, we attempt to replicate the fatigue-induced decline in voluntary surface electromyography (EMG) and motor evoked potentials (MEPs) observed in previous studies and determine: (1) if this decline can be attributed to central failure, and (2) whether this failure is offset by caffeine."	9.11	Central fatigue and transcranial magnetic stimulation: effect of caffeine and the confound of peripheral transmission failure. ( Cafarelli, E; Kalmar, JM, 2004)
"A randomized, double-blind, placebo-controlled, multicenter study was conducted to ascertain the contribution of Fiorinal and codeine phosphate to the efficacy of Fiorinal with Codeine in relieving the pain, tension, and muscle stiffness associated with tension headache."	9.06	Assessment of Fiorinal with Codeine in the treatment of tension headache. ( Friedman, AP, 1986)
" Recent studies have shown beneficial effects of an adenosine A(2A) receptor agonist in dt(sz) mutant hamsters, an animal model of paroxysmal dystonia, in which stress and consumption of coffee can precipitate dystonic attacks."	7.71	Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. ( Hamann, M; Richter, A, 2001)
"Contracture responses of intact cut masseter and vastus bundles (non-skinned) do not differ with respect to caffeine and halothane."	7.70	Caffeine- or halothane-induced contractures of masseter muscle are similar to those of vastus muscle in normal humans. ( Antognini, JF; Gronert, GA; Melton, AT, 1999)
"The contractile activity, the threshold for calcium-induced calcium release in fractions of sarcoplasmic reticulum and the potassium concentration were determined in preparations of semimembranosus muscle from normal quarter horses and quarter horses with hyperkalaemic periodic paralysis before and after they were treated with phenytoin."	7.69	Effect of phenytoin on skeletal muscle from quarter horses with hyperkalaemic periodic paralysis. ( Beech, J; Dawso, T; Fletcher, JE; Lindborg, S; Tripolitis, L, 1995)
" We evaluated whether toxic concentrations of cocaine altered the in vitro muscle response to halothane during contracture tests for MH."	7.69	Effect of cocaine on the contracture response to 1% halothane in patients undergoing diagnostic muscle biopsy for malignant hyperthermia. ( Brum, JM; DeBoer, GE; Mitsumoto, H; Sato, N, 1995)
"The Ca2+ sensitivity of cardiac myofibrillar force production can be decreased by acidosis or inorganic phosphate (P(i)) and increased by caffeine."	7.69	Developmental differences and regional similarities in the responses of rat cardiac skinned muscles to acidosis, inorganic phosphate and caffeine. ( Kentish, JC; Palmer, S, 1996)
" The effects of haloperidol on smooth muscle contraction induced by carbachol, histamine, high K or caffeine in the presence or absence of extracellular Ca were investigated."	7.68	Haloperidol differentiates smooth muscle contractions induced by release of intracellularly stored Ca and by influx of extracellular Ca. ( Hishinuma, S; Hongo, I; Kurokawa, M; Uchida, MK, 1992)
" The potency (pD2 value) of phenylephrine increased with age from 3 to 10 weeks, but decreased thereafter from 10 to 80 weeks, while the affinity (pKA value) of phenylephrine to alpha 1-adrenoceptors did not alter with aging."	7.68	Contractile responses of rat aorta to phenylephrine and serotonin, and aging. ( Ohtsuki, H; Onozuka, S; Shinkai, M; Takayanagi, I, 1991)
"The in vitro halothane and caffeine contracture tests have been performed on muscle tissue from six survivors of the neuroleptic malignant syndrome."	7.67	Neuroleptic malignant syndrome and malignant hyperthermia. In vitro comparison with halothane and caffeine contracture tests. ( Adnet, P; Guevart, E; Krivosic-Horber, R; Lestavel, P; Theunynck, D, 1987)
"Using the skinned fiber preparation, the response to caffeine was studied on the skeletal muscle of malignant hyperthermia or other neuromuscular diseases."	7.66	Malignant hyperthermia and related neuromuscular diseases: caffeine contracture of the skinned muscle fibers. ( Ishihara, T; Nonaka, I; Sugita, H; Sunohara, N; Takagi, A, 1983)
"We evaluated six boys who had developed isolated masseter muscle spasm following intravenous succinylcholine."	7.66	Masseter spasm induced by succinylcholine in children: contracture testing for malignant hyperthermia: report of six cases. ( Flewellen, EH; Nelson, TE, 1982)
"Caffeine is a powerful metabolic stimulant in the skeletal muscle that has ergogenic effects, including enhanced muscle power output and endurance capacity."	5.51	The Effects of Caffeine on Metabolomic Responses to Muscle Contraction in Rat Skeletal Muscle. ( Egawa, T; Hayashi, T; Tsuda, S, 2019)
" The objective of this study was to assess the effects of caffeine supplementation on jump height, average power (AP), peak power (PP), maximum velocity (Vmax), force production and duration of the eccentric, isometric and concentric muscle contraction phases of a CMJ."	5.41	Caffeine improves performance but not duration of the countermovement jump phases. ( Bailey, S; DomÍnguez, R; Jodra, P; Lago-RodrÍguez, Á, 2021)
"Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days."	5.35	Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008)
"The association of malignant hyperthermia (MH) with neuromuscular disorders has been recognized since 1970."	5.27	Halothane-caffeine contracture testing in neuromuscular diseases. ( Fletcher, JE; Heiman-Patterson, TD; Rosenberg, H; Tahmoush, AJ, 1988)
"The ingestion of a moderate dose of caffeine counteracts the muscle contraction velocity declines observed in the morning against a wide range of loads."	5.20	Improvements on neuromuscular performance with caffeine ingestion depend on the time-of-day. ( Fernández-Elías, VE; López-Gullón, JM; López-Samanes, Á; Mora-Rodríguez, R; Ortega, JF; Pallarés, JG, 2015)
"To determine the effect of water, carbohydrate, and caffeine ingestion on fatigue during prolonged exercise in the heat."	5.13	Caffeine effects on short-term performance during prolonged exercise in the heat. ( Del Coso, J; Estevez, E; Mora-Rodriguez, R, 2008)
"We hypothesized that if reduced spinal excitability contributes to central activation failure, then a caffeine-induced increase in spinal excitability would enhance postfatigue maximal voluntary activation and maximal voluntary contraction (MVC)."	5.12	Increased spinal excitability does not offset central activation failure. ( Cafarelli, E; Del Balso, C; Kalmar, JM, 2006)
" kg(-1) body weight dose of caffeine on delayed-onset muscle pain intensity and force loss in response to 64 eccentric actions of the dominant quadriceps induced by electrical stimulation."	5.12	Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise. ( Dudley, GA; Maridakis, V; McCully, KK; O'Connor, PJ, 2007)
"This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain and blood pressure during moderate intensity cycling exercise."	5.11	Dose-dependent effect of caffeine on reducing leg muscle pain during cycling exercise is unrelated to systolic blood pressure. ( Broglio, SP; Ely, MR; Motl, RW; O'Connor, PJ, 2004)
"In this experiment, we attempt to replicate the fatigue-induced decline in voluntary surface electromyography (EMG) and motor evoked potentials (MEPs) observed in previous studies and determine: (1) if this decline can be attributed to central failure, and (2) whether this failure is offset by caffeine."	5.11	Central fatigue and transcranial magnetic stimulation: effect of caffeine and the confound of peripheral transmission failure. ( Cafarelli, E; Kalmar, JM, 2004)
"A randomized, double-blind, placebo-controlled, multicenter study was conducted to ascertain the contribution of Fiorinal and codeine phosphate to the efficacy of Fiorinal with Codeine in relieving the pain, tension, and muscle stiffness associated with tension headache."	5.06	Assessment of Fiorinal with Codeine in the treatment of tension headache. ( Friedman, AP, 1986)
" In our study, the administration of atropine or caffeine did not cause classic muscle contractions of F."	3.81	Pharmacological and morphological characteristics of the muscular system of the giant liver fluke (Fascioloides magna - Bassi 1875). ( Aničić, MR; Marinković, D; Marjanović, DS; Milovanović, M; Trailović, JN; Trailović, SM, 2015)
"Caffeine may promote incontinence through its diuretic effect, particularly in individuals with underlying detrusor overactivity, in addition to increasing muscle contraction of the bladder smooth muscle."	3.80	Caffeine enhances micturition through neuronal activation in micturition centers. ( Cho, YS; Chung, JY; Hwan, L; Jin, JJ; Kim, CJ; Kim, KH; Kim, SE; Kim, SH; Ko, IG; Shin, MS, 2014)
" Rat hindlimbs were perfused at rest (n = 16), with 3 mM caffeine (n = 15), with 2 mM 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside (AICAR; n = 16), or during moderate-intensity muscle contraction (MC; n = 14) and with or without 5 microM STO-609, a CaMKK inhibitor."	3.75	CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle. ( Abbott, MJ; Edelman, AM; Turcotte, LP, 2009)
" In this study, we investigated the effect of caffeine and theophylline--both are nonselective inhibitors of phosphodiesterase--on urinary bladder smooth muscle contractions evoked by acetylcholine."	3.74	In vitro reactivity of urinary bladder smooth muscle in rabbits influenced by xanthine derivatives. ( Mokry, J; Nosalova, G, 2008)
" Caffeine, a sarcoplasmic reticulum (SR) Ca2+-releasing agent, at a concentration that does not cause muscle contractions or decreases in high-energy phosphates, led to an approximately 2-fold increase in 2-deoxyglucose (2-DG) uptake in isolated split soleus muscles."	3.73	Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle. ( Geiger, PC; Han, DH; Holloszy, JO; Wright, DC, 2005)
" Caffeine and ryanodine contractions were augmented during endotoxemia without NOS contribution."	3.72	The role of nitric oxide on contractile impairment during endotoxemia in rat diaphragm muscle. ( Ertunc, M; Onur, R; Sara, Y, 2004)
" Recent studies have shown beneficial effects of an adenosine A(2A) receptor agonist in dt(sz) mutant hamsters, an animal model of paroxysmal dystonia, in which stress and consumption of coffee can precipitate dystonic attacks."	3.71	Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. ( Hamann, M; Richter, A, 2001)
"Skeletal muscle contraction is triggered by the release of Ca2+ from the sarcoplasmic reticulum through the type 1 ryanodine receptor (RyR1)."	3.70	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors. ( Allen, PD; Barone, V; Bertocchini, F; Bottinelli, R; Franzini Armstrong, C; Protasi, F; Reggiani, C; Sorrentino, V, 1998)
"Twitch time course measurements and contracture responses to various concentrations of caffeine and halothane for small bundles of intact external intercostal muscle fibers were measured in all horses."	3.70	In vitro contractile responses and contracture testing of skeletal muscle from Quarter Horses with exertional rhabdomyolysis. ( Gallant, EM; Lentz, LR; Mickelson, JR; Valberg, SJ, 1999)
"Contracture responses of intact cut masseter and vastus bundles (non-skinned) do not differ with respect to caffeine and halothane."	3.70	Caffeine- or halothane-induced contractures of masseter muscle are similar to those of vastus muscle in normal humans. ( Antognini, JF; Gronert, GA; Melton, AT, 1999)
"The contractile activity, the threshold for calcium-induced calcium release in fractions of sarcoplasmic reticulum and the potassium concentration were determined in preparations of semimembranosus muscle from normal quarter horses and quarter horses with hyperkalaemic periodic paralysis before and after they were treated with phenytoin."	3.69	Effect of phenytoin on skeletal muscle from quarter horses with hyperkalaemic periodic paralysis. ( Beech, J; Dawso, T; Fletcher, JE; Lindborg, S; Tripolitis, L, 1995)
" We evaluated whether toxic concentrations of cocaine altered the in vitro muscle response to halothane during contracture tests for MH."	3.69	Effect of cocaine on the contracture response to 1% halothane in patients undergoing diagnostic muscle biopsy for malignant hyperthermia. ( Brum, JM; DeBoer, GE; Mitsumoto, H; Sato, N, 1995)
" A23187-induced muscle contractions included two components: one which required the influx of extracellular Ca2+ through Ca2+ channels (blocked by cobalt ions), the other not blocked by cobalt ions."	3.69	Mode of action of an inhibitory neuropeptide SchistoFLRFamide on the locust oviduct visceral muscle. ( Chen, X; Lange, AB; Orchard, I; Wang, Z, 1995)
" We investigated the effects of acidosis, inorganic phosphate (Pi) and caffeine on the Ca2+ affinity of isolated fast-twitch skeletal and cardiac troponin C (TnC), labelled with fluorescent probes to report Ca2+ binding to the regulatory sites."	3.69	The role of troponin C in modulating the Ca2+ sensitivity of mammalian skinned cardiac and skeletal muscle fibres. ( Kentish, JC; Palmer, S, 1994)
"The Ca2+ sensitivity of cardiac myofibrillar force production can be decreased by acidosis or inorganic phosphate (P(i)) and increased by caffeine."	3.69	Developmental differences and regional similarities in the responses of rat cardiac skinned muscles to acidosis, inorganic phosphate and caffeine. ( Kentish, JC; Palmer, S, 1996)
"The role of adenosine in regulating glycogen breakdown during electrically induced muscle contractions was investigated in isolated rat hindquarters perfused with a standard medium either lacking or containing 100 microU/ml insulin and/or 1."	3.69	Adenosine exerts a glycogen-sparing action in contracting rat skeletal muscle. ( Hespel, P; Richter, EA; Vergauwen, L, 1997)
" In vitro, human MHS muscle samples were exposed to propofol and changes in (a) baseline tension and (b) contracture tension on exposure to halothane and caffeine were measured."	3.68	Propofol is a 'safe' anaesthetic agent in malignant hyperthermia susceptible patients. ( Couchman, KG; McKenzie, AJ; Pollock, N, 1992)
" The effects of haloperidol on smooth muscle contraction induced by carbachol, histamine, high K or caffeine in the presence or absence of extracellular Ca were investigated."	3.68	Haloperidol differentiates smooth muscle contractions induced by release of intracellularly stored Ca and by influx of extracellular Ca. ( Hishinuma, S; Hongo, I; Kurokawa, M; Uchida, MK, 1992)
"The in vitro contracture test determines the sensitivity of freshly obtained skeletal muscle specimens to caffeine or halothane applied to a bathing solution."	3.68	In vitro contracture testing for determination of susceptibility to malignant hyperthermia: a methodologic update. ( Gallagher, WJ; Iaizzo, PA; Wedel, DJ, 1991)
" The potency (pD2 value) of phenylephrine increased with age from 3 to 10 weeks, but decreased thereafter from 10 to 80 weeks, while the affinity (pKA value) of phenylephrine to alpha 1-adrenoceptors did not alter with aging."	3.68	Contractile responses of rat aorta to phenylephrine and serotonin, and aging. ( Ohtsuki, H; Onozuka, S; Shinkai, M; Takayanagi, I, 1991)
"In order to evaluate the mechanisms of weakness in muscles of patients with myasthenia gravis (MG), intercostal muscle biopsies were obtained from 9 normal subjects and 6 MG patients, and the compound muscle action potential (AP) and tension responses to nerve and muscle stimulation, and contracture responses on exposure to caffeine, were monitored in vitro."	3.68	Responses of intercostal muscle biopsies from normal subjects and patients with myasthenia gravis. ( Grob, D; Namba, T; Nandakumar, NV; Pagala, MK; Ravindran, K; Venkatachari, SA, 1990)
"Since the membrane Ca2+ handling properties of the arterial smooth muscle sarcoplasmic reticulum may be altered in genetic hypertension, we studied caffeine- and noradrenaline-induced contractions in tail arteries from spontaneously hypertensive rats (SHR) at the prehypertensive stage (4 weeks old) and from age-matched Wistar-Kyoto rats (WKY)."	3.68	Alteration in sarcoplasmic reticulum-dependent contraction of tail arteries in response to caffeine and noradrenaline in spontaneously hypertensive rats. ( Aoki, K; Dohi, Y; Fujimoto, S; Kojima, M; Matsuda, T, 1990)
"The mechanism of the inhibitory effect of caffeine on smooth muscle contraction was examined using chicken gizzard."	3.68	Direct inhibition of chicken gizzard smooth muscle contractile apparatus by caffeine. ( Hori, M; Ishihara, H; Karaki, H; Kasai, H; Ozaki, H; Sato, K, 1990)
"Evidence suggests that ryanodine affects ligand-gated calcium channels in the sarcoplasmic reticulum (SR) resulting in depressed muscle contraction."	3.67	Mechanisms of ryanodine-induced depression of caffeine-induced tension transients in skinned striated rabbit muscle fibers. ( Su, JY, 1988)
" The in vitro halothane-caffeine contracture tests are the most reliable method of identifying individuals susceptible to MH."	3.67	The association between the neuroleptic malignant syndrome and malignant hyperthermia. ( Adamantidis, MM; Adnet, PJ; Adnet-Bonte, CA; Dupuis, BA; Haudecoeur, G; Krivosic-Horber, RM; Saulnier, F, 1989)
"The in vitro halothane and caffeine contracture tests have been performed on muscle tissue from six survivors of the neuroleptic malignant syndrome."	3.67	Neuroleptic malignant syndrome and malignant hyperthermia. In vitro comparison with halothane and caffeine contracture tests. ( Adnet, P; Guevart, E; Krivosic-Horber, R; Lestavel, P; Theunynck, D, 1987)
" Muscle contraction could be elicited by caffeine even after UER-treatment but then only the slow tension increase (second phase of normal caffeine contraction) occurred (Fig."	3.67	Discoupling of excitation-contraction processes by urea treatment of frog skeletal muscle. ( Gesztelyi, I; Kathó, J; Kövér, A, 1986)
"Seventy-seven patients who developed masseter muscle rigidity (MMR) after receiving succinylcholine to facilitate tracheal intubation were evaluated for malignant hyperthermia (MH) susceptibility by in vitro halothane and caffeine contracture tests."	3.67	Masseter muscle rigidity and malignant hyperthermia susceptibility. ( Fletcher, JE; Rosenberg, H, 1986)
"Studies were conducted on the effects of isoflurane and halothane on intracellular mechanisms of striated muscle contraction: Ca2+ activation of the contractile proteins and Ca2+ uptake and release from the sarcoplasmic reticulum."	3.67	Intracellular mechanism of action of isoflurane and halothane on striated muscle of the rabbit. ( Bell, JG; Su, JY, 1986)
"The mode of action of papaverine on smooth muscle relaxation was examined through analyzing its effects on caffeine-induced contraction of guinea pig taenia coli, which might be due to calcium ion mobilized from intracellular store sites."	3.66	Mechanism of relaxant action of papaverine. Effect on caffeine-induced contraction of guinea pig taenia coli. ( Kubota, K; Sunagane, N; Uruno, T, 1982)
"Using the skinned fiber preparation, the response to caffeine was studied on the skeletal muscle of malignant hyperthermia or other neuromuscular diseases."	3.66	Malignant hyperthermia and related neuromuscular diseases: caffeine contracture of the skinned muscle fibers. ( Ishihara, T; Nonaka, I; Sugita, H; Sunohara, N; Takagi, A, 1983)
"We evaluated six boys who had developed isolated masseter muscle spasm following intravenous succinylcholine."	3.66	Masseter spasm induced by succinylcholine in children: contracture testing for malignant hyperthermia: report of six cases. ( Flewellen, EH; Nelson, TE, 1982)
"In a double-blind, placebo-controlled study on parallel groups of medical students diazepam 10 mg impaired cognitive skills and caused muscle relaxation."	3.66	Caffeine antagonizes diazepam effects in man. ( Mattila, MJ; Palva, E; Savolainen, K, 1982)
"This clinical study of 62 patients with restless legs syndrome and associated anxious-depressed and other clinical states seems to indicate that caffeine is the major etiological factor in the causation of the restless legs syndrome."	3.66	Restless legs, anxiety and caffeinism. ( Lutz, EG, 1978)
" Using muscle from patients susceptible to malignant hyperpyrexia in vitro, it has been demonstrated that muscle contracture can occur with procaine on its own, and in one patient the halothane-induced contracture was potentiated by procaine."	3.65	An evaluation of procaine in the treatment of malignant hyperpyrexia. ( Clarke, IM; Ellis, FR, 1975)
"Halothane-induced contractures in isolated muscle fibers from swine susceptible to malignant hyperthermia (MHS) were significantly less when fibers were incubated in KRB plus 6."	3.65	Porcine malignant hyperthermia: effect of dantrolene sodium on in-vitro halothane-induced contraction of susceptible muscle. ( Anderson, IL; Jones, EW, 1976)
"Caffeine (500 mg) was administered orally in a double-blind fashion."	2.65	Effect of caffeine on skeletal muscle function before and after fatigue. ( Aranda, JV; Aubier, M; Jardim, J; Lopes, JM; Macklem, PT, 1983)
" However, the differences between sexes are evident in terms of body size, body composition, and hormonal functioning, which might cause different outcomes on performance for the same dosage of caffeine intake in men vs."	2.61	Effect of Caffeine Supplementation on Sports Performance Based on Differences Between Sexes: A Systematic Review. ( Calleja-González, J; Del Coso, J; León-Guereño, P; Marques-Jiménez, D; Mielgo-Ayuso, J; Refoyo, I, 2019)
"Malignant hyperthermia is a hypermetabolic syndrome that appears in susceptible patients after exposure to certain anaesthetic drugs (succinylcholine, inhalation anaesthetics)."	2.55	Clinical protocol for the management of malignant hyperthermia. ( Alsina, E; Del Blanco, B; Domínguez, A; García, A; Guerrero, JL; Kollmann-Camaiora, A; Yepes, MJ, 2017)
"The problem of malignant hyperthermia may become worse in the near future due to changes in the population brought about by immigration."	2.44	[Anesthesia in malignant hyperthermia]. ( Ortiz Gómez, JR, 2008)
"Caffeine is a very common CNS stimulant that has been of interest to physiologists because of its direct effects on skeletal muscle in vitro, as well as ergogenic effects on laboratory tests of human performance."	2.43	The influence of caffeine on voluntary muscle activation. ( Kalmar, JM, 2005)
"Caffeine is able to increase muscle contractility, has no ergogenic effect on intense exercise of brief duration, but can improve the time before exhaustion."	2.39	Caffeine and sports activity: a review. ( Debry, G; Nehlig, A, 1994)
"Most patients with malignant hyperthermia susceptibility diagnosed by the in vitro caffeine-halothane contracture test (CHCT) develop excessive force in response to halothane but not caffeine (halothane-hypersensitive)."	1.91	Distinct pathophysiological characteristics in developing muscle from patients susceptible to malignant hyperthermia. ( Figueroa, L; Ibarra-Moreno, CA; Kraeva, N; Manno, C; Riazi, S; Rios, E; Tammineni, ER, 2023)
"Exertional heat illness (EHI) and malignant hyperthermia (MH) are life threatening conditions associated with muscle breakdown in the setting of triggering factors including volatile anesthetics, exercise, and high environmental temperature."	1.72	Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility. ( Celik, A; Dirksen, RT; Dowling, JJ; Endo, Y; Gardner, L; Groom, L; Hamilton, SL; Hopkins, PM; Jung, SY; Kraeva, N; Lee, CS; Riazi, S; Shaw, MA, 2022)
"The variable clinical presentation of malignant hyperthermia (MH), a disorder of calcium signalling, hinders its diagnosis and management."	1.51	Abnormal calcium signalling and the caffeine-halothane contracture test. ( Figueroa, L; Kraeva, N; Manno, C; Riazi, S; Ríos, E; Toro, S, 2019)
"Caffeine is a well-established performance enhancing nutritional supplement in a young healthy population, however far less is known about how its ergogenicity is affected by increasing age."	1.46	Is the Ergogenicity of Caffeine Affected by Increasing Age? The Direct Effect of a Physiological Concentration of Caffeine on the Power Output of Maximally Stimulated EDL and Diaphragm Muscle Isolated from the Mouse. ( Cox, VM; Duncan, MJ; James, RS; Tallis, J, 2017)
"Hydrogen sulfide is an endogenous gasotransmitter and its mechanism of action involves activation of ATP-sensitive K(+) channels and phosphodiesterase inhibition."	1.43	Cystathionine β-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia. ( Andria, B; Attanasio, C; Bucci, M; Calderone, V; Cantalupo, A; Cirino, G; Di Martino, A; Ianaro, A; Mancini, A; Panza, E; Savoia, G; Vellecco, V, 2016)
"Several malignant hyperthermia-associated neuromuscular diseases are associated with an altered connective tissue composition."	1.40	Contractile elements in muscular fascial tissue - implications for in-vitro contracture testing for malignant hyperthermia. ( Hoppe, K; Jäger, H; Klingler, W; Lehmann-Horn, F; Schleip, R, 2014)
"Hypertension is often associated with skeletal muscle pathological conditions related to function and metabolism."	1.40	Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats: cytofluorimetric and gene expression analysis. ( Camerino, GM; Cannone, M; Conte Camerino, D; Conte, E; De Bellis, M; Fraysse, B; Liantonio, A; Pierno, S; Scaramuzzi, A; Tricarico, D, 2014)
"The clinical symptoms resemble malignant hyperthermia (MH), which may lead to mistreatment of the patient."	1.39	In vitro muscle contracture investigations on the malignant hyperthermia like episodes in myotonia congenita. ( Adolph, O; Chaiklieng, S; Hoppe, K; Jurkat-Rott, K; Klingler, W; Lehmann-Horn, F, 2013)
"Caffeine treatment of 70 μM resulted in significant improvements in PO in maximally and submaximally activated EDL and soleus (P < 0."	1.38	The effect of physiological concentrations of caffeine on the power output of maximally and submaximally stimulated mouse EDL (fast) and soleus (slow) muscle. ( Cox, VM; Duncan, MJ; James, RS; Tallis, J, 2012)
"Cardiac muscle contraction is initiated by the entry of Ca²⁺ ions from the extracellular spaces and the Ca²⁺ stores in the sarcoplasmic reticulum into the myoplasm."	1.38	Potential role of Hsp25 in calcium-modulated cardiomyocytes. ( Das, T; Rhim, H; Song, EJ; Yoo, YS, 2012)
"Caffeine is known to inhibit cyclic nucleotide phosphodiesterases (PDEs), leading to an increase in cytosolic cAMP and stimulation of downstream cAMP-dependent mechanisms."	1.37	Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances. ( Britton, F; Dixon, R; Hwang, S; Sanders, K; Ward, S, 2011)
"To diagnose malignant hyperthermia (MH) susceptibility, muscle bundles are exposed to halothane and caffeine."	1.37	Sevoflurane as a potential replacement for halothane in diagnostic testing for malignant hyperthermia susceptibility: results of a preliminary study. ( Anetseder, M; Hartung, E; Metterlein, T; Roewer, N; Schuster, F, 2011)
"Sertraline was ineffective against contractions induced by extracellular Ca(2+) restoration after thapsigargin treatment and Ca(2+) store depletion with phenylephrine."	1.37	Inhibitory effects of sertraline in rat isolated perfused kidneys and in isolated ring preparations of rat arteries. ( Alves, RS; de Siqueira, RJ; Fonseca-Magalhães, PA; Jorge, RJ; Magalhães, PJ; Martins, AM; Meneses, GC; Monteiro, HS; Sousa, DF, 2011)
"Acute colitis was induced in C57Bl/6 mice with dextran sulphate sodium (DSS) in the drinking water for 5 days."	1.36	CaM kinase II in colonic smooth muscle contributes to dysmotility in murine DSS-colitis. ( Hennig, GW; Koh, SD; Lee, HT; Perrino, BA; Qureshi, S; Song, J, 2010)
"Phenol is a neurolytic agent used for management of spasticity in patients with either motoneuron lesions or stroke."	1.36	Phenol increases intracellular [Ca2+] during twitch contractions in intact Xenopus skeletal myofibers. ( Hogan, MC; Nogueira, L, 2010)
"Caffeine contractures were diminished in exercised rat EDL (P <0."	1.36	Exercise and suspension hypokinesia-induced alterations in mechanical properties of rat fast and slow-twitch skeletal muscles. ( Atalay, A; Ertunc, M; Onur, R; Yildirim, M, 2010)
"Both caffeine treatment and electrical stimulation significantly increased FA uptake and oxidation."	1.35	Evidence for the involvement of CaMKII and AMPK in Ca2+-dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscle. ( Raney, MA; Turcotte, LP, 2008)
"Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days."	1.35	Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008)
"When caffeine was applied in Ca(2+)-free solution, the [Ca(2+)](i) transients decreased as the interval between Ca(2+) removal and caffeine application was increased, indicating a possible leakage of Ca(2+) in these stores."	1.33	Characterization of intracellular Ca(2+) stores in gallbladder smooth muscle. ( Camello, PJ; Mawe, GM; Morales, S; Pozo, MJ, 2005)
"When nifedipine and amiloride were applied together, either type of contraction was still appreciable."	1.33	Sources of activator calcium ions in the contraction of smooth muscles in Aplysia kurodai. ( Huang, Z; Ishii, Y; Liu, H; Miyake, S; Suzaki, T; Tsuchiya, T; Watari, T, 2005)
"We report the first case of malignant hyperthermia, verified by caffeine-halothane contracture test and genetic testing, in a Chinese patient."	1.33	Malignant hyperthermia in China. ( Guo, XY; Huang, YG; Luo, AL; Ren, HZ; Wang, YL; Xu, ZH; Ye, TH; Zhang, X, 2006)
"Chelerythrine (12 micro M) was shown to restore ECC in these fibres."	1.32	The effect of chelerythrine on depolarization-induced force responses in skinned fast skeletal muscle fibres of the rat. ( Bakker, AJ; Han, R, 2003)
"Nandrolone decanoate treatment thus affects Ca (2+) uptake by the SR in a fibre-type dependent manner."	1.32	Nandrolone decanoate treatment affects sarcoplasmic reticulum Ca(2+) ATPase function in skinned rat slow- and fast-twitch fibres. ( Bouhlel, A; Joumaa, WH; Léoty, C, 2003)
"To determine whether malignant hyperthermia (MH) susceptibility in a Canadian pedigree is associated with a mutation in the ryanodine receptor subtype 1 (RYR1) gene, the complete RYR1 transcript obtained from the leukocytes of one MH-susceptible family member was sequenced, using a newly developed protocol."	1.32	Detection of a novel ryanodine receptor subtype 1 mutation (R328W) in a malignant hyperthermia family by sequencing of a leukocyte transcript. ( Du, G; Kraev, A; Kraev, N; Loke, JC; MacLennan, DH; Patel, L; Sharma, P, 2003)
"Caffeine (6 mg/kg) was administered on one day and a placebo was administered on the other."	1.32	Caffeine increases spinal excitability in humans. ( Cafarelli, E; Kalmar, J; Walton, C, 2003)
"Caffeine treatment also resulted in increased phosphorylation of calmodulin-dependent protein kinase (CAMK)-II in epitrochlearis muscle."	1.32	Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions. ( Han, DH; Holloszy, JO; Hucker, KA; Wright, DC, 2004)
"The diagnosis of susceptibility to malignant hyperthermia (MH) is currently performed on muscle biopsies subjected to halothane-caffeine in vitro contracture tests (IVCTs)."	1.32	Comparative analysis of in vitro contracture tests with ryanodine and a combination of ryanodine with either halothane or caffeine: a comparative investigation in malignant hyperthermia. ( Bendahan, D; Cozzone, PJ; Ghattas, B; Guis, S; Kozak-Ribbens, G; Lunardi, J; Mattei, JP; Monnier, N, 2004)
" Baseline tone, electrical field stimulation (EFS)-induced nitric oxide-mediated off responses, and changes in the cholecystokinin (CCK)-8 dose-response relationship were measured."	1.31	The effect of phosphodiesterase inhibition on gallbladder motility in vitro. ( Conklin, JL; Cullen, JJ; Hinkhouse, MM; Lindaman, BA, 2002)
"Nandrolone decanoate pre-treatment of suspended animals (nandrolone decanoate hindlimb-unweighted vs."	1.31	Nandrolone decanoate pre-treatment attenuates unweighting-induced functional changes in rat soleus muscle. ( Bigard, X; Bouhlel, A; Joumaa, WH; Léoty, C, 2002)
"The rabbit inferior vena cava (IVC) is a large-capacitance vessel that displays typical contractile dose-response curves for caffeine and phenylephrine (PE)."	1.31	Asynchronous Ca(2+) waves in intact venous smooth muscle. ( Lee, CH; Poburko, D; Ruehlmann, DO; van Breemen, C, 2000)
"The diagnosis of malignant hyperthermia susceptibility relies on the in vitro contracture test on skeletal muscle."	1.31	Contractures in skeletal muscle of malignant hyperthermia susceptible patients after in vitro exposure to sevoflurane. ( Dirksen, R; Gielen, MJ; Snoeck, MM; Tangerman, A; van Egmond, J, 2000)
"Caffeine is known to produce various effects on the gastrointestinal tract."	1.31	Effects of caffeine on gastrointestinal myoelectric activity and colonic spike activity in dogs. ( Abo, M; Chen, JD; Kono, T; Lu, CL, 2000)
"The diagnostic outcomes of tests for malignant hyperthermia susceptibility were compared between two laboratories by using muscle tissue from the same patients."	1.31	Between-center variability of results of the in vitro contracture test for malignant hyperthermia susceptibility. ( Bendixen, D; Islander, G; Ording, H; Ranklev-Twetman, E, 2000)
" Furthermore, an increase in cytosolic Ca(2+) activity induced a more marked shift of dose-response curves toward lower concentrations for 4-CmC than caffeine."	1.31	Differential effects of 4-chloro-m-cresol and caffeine on skinned fibers from rat fast and slow skeletal muscles. ( Choisy, S; Huchet-Cadiou, C; Léoty, C, 2000)
"Whether these complications are malignant hyperthermia (MH) or not has several times been discussed."	1.31	[Malignant hyperthermia of Duchenne muscular dystrophy: application of clinical grading scale and caffeine contracture of skinned muscle fibers]. ( Takagi, A, 2000)
"Xenon 70% did not cause an increase in baseline tension of any MH-susceptible muscle specimen in contrast to halothane and caffeine."	1.31	Xenon does not induce contracture in human malignant hyperthermia muscle. ( Baur, CP; Froeba, G; Georgieff, M; Jurkat-Rott, K; Klingler, W; Lehmann-Horn, F; Marx, T; Schoch, E, 2000)
"Caffeine contractures were increased only after the exercise training."	1.31	Differential effects of nandrolone decanoate in fast and slow rat skeletal muscles. ( Joumaa, WH; Léoty, C, 2001)
"Caffeine was used as a tool to investigate whether the sarcoplasmic reticulum (SR) properties in single."	1.31	Caffeine thresholds for contraction in electrophoretically typed, mechanically skinned muscle fibres from SHR and WKY rats. ( Bortolotto, SK; Stephenson, DG; Stephenson, GM, 2001)
"The determination of susceptibility to malignant hyperthermia (MH) by genetic investigation is a controversial issue because of the genetic heterogeneity of this disorder."	1.31	Homozygous and heterozygous Arg614Cys mutations (1840C-->T) in the ryanodine receptor gene co-segregate with malignant hyperthermia susceptibility in a German family. ( Deutrich, C; Froster, UG; Olthoff, D; Rueffert, H; Thamm, B, 2001)
"Taurine may increase the size of depolarisation-induced force responses by augmenting SR Ca(2+) accumulation and release."	1.31	Effect of taurine on sarcoplasmic reticulum function and force in skinned fast-twitch skeletal muscle fibres of the rat. ( Bakker, AJ; Berg, HM, 2002)
"Ryanodine at 50 microM has no effect on electrically-evoked contractions."	1.30	Contraction and relaxation in the absence of a sarcoplasmic reticulum: muscle fibres in the small pelagic tunicate Doliolum. ( Bone, Q; Inoue, I; Tsutsui, I, 1997)
" MHEh muscles revealed a dose-response curve similar to that found in MHN specimens."	1.30	Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol. ( Bittner, RE; Fricker, R; Gilly, H; Kress, HG; Musat, I; Steinbereithner, K, 1997)
"Chlorocresol was demonstrated to be a potent activator of Ca++ release from skeletal muscle sarcoplasmic reticulum."	1.30	[Effect of chlorocresol vs caffeine on muscle contracture in malignant hyperthermia susceptible patients]. ( Adnet, PJ; Ben-Abraham, R; Haudcoeur, G; Krivosic-Horber, RM; Perel, A, 1997)
"The association between malignant hyperthermia (MH) and neuromuscular disorders is controversial."	1.30	Dystrophin deficient mdx muscle is not prone to MH susceptibility: an in vitro study. ( Bittner, RE; Gilly, H; Mader, N, 1997)
"(+)-Propranolol (which has 100 times less beta-blocking activity than the (+/-) form) was approximately one third as effective as the (+/-) form at inhibiting isometric tension."	1.30	Inhibitory effects of (+/-)-propranolol on excitation-contraction coupling in isolated soleus muscles of the rat. ( Fryer, MW; Ha, TN, 1997)
"6."	1.30	Endothelin receptor-mediated Ca2+ mobilization and contraction in bovine oviductal arteries: comparison with noradrenaline and potassium. ( Costa, G; García-Pascual, A; Jimenez, E; Labadía, A; Triguero, D, 1997)
"Cicletanine did not inhibit contraction induced by Ca2+ in the permeabilized rabbit mesenteric artery with alpha-toxin."	1.30	Cicletanine-induced decreases in cytosolic Ca2+ level and contraction in vascular smooth muscle. ( Izumi, M; Karaki, H; Mitsui-Saito, M; Ozaki, H, 1998)
"In ryanodine-treated strips, which had functionally lost the histamine-sensitive Ca2+ storage sites, histamine (3 microM) slowly increased [Ca2+]i and force."	1.30	Effect of cilostazol, a phosphodiesterase type III inhibitor, on histamine-induced increase in [Ca2+]i and force in middle cerebral artery of the rabbit. ( Itoh, T; Kanmura, Y; Shiraishi, Y, 1998)
"Caffeine (10 mM) was used to release calcium from the SR."	1.30	Effects of cyclic adenosine monophosphate (cAMP) on sarcoplasmic reticulum Ca(2+)-loading in failing rabbit and human cardiac trabeculae. ( Cobbe, SM; Denvir, MA; MacFarlane, NG; Miller, DJ, 1998)
"Regulation of muscle contraction is abnormal in Thoroughbreds with RER."	1.30	Abnormal regulation of muscle contraction in horses with recurrent exertional rhabdomyolysis. ( Balog, EM; Gallant, EM; Lentz, LR; Mickelson, JR; Valberg, SJ, 1999)
" The type of fibres (type I: oxidative, slow; type II: glycolytic, fast) were determined with strontium dose-response curves."	1.30	[Caffeine skinned fiber tension test: application to the diagnosis of susceptibility to malignant hyperthermia]. ( Adnet, P; Börtlein, ML; Etchrivi, T; Haudecoeur, G; Krivosic-Horber, R; Nivoche, Y; Tavernier, B, 1999)
"In Quarter Horses, rhabdomyolysis is commonly due to a glycogen storage disorder, PSSM, and is readily expressed in untrained horses."	1.30	Exertional rhabdomyolysis in quarter horses and thoroughbreds: one syndrome, multiple aetiologies. ( de la Corte, F; Gallant, EM; Lentz, L; MacLeay, JM; Mickelson, JR; Valberg, SJ, 1999)
"Treatment with ramipril reduced blood pressure and force development in response to Bay K8644 in adult SHRSP, although not to levels of WKY rats, whereas WKY rats were unaffected by treatment."	1.29	Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats. ( Traub, O; Webb, RC, 1993)
"Pretreatment with thapsigargin abolished agonist-induced 45Ca2+ efflux in both cell types."	1.29	Agonist-activated, ryanodine-sensitive, IP3-insensitive Ca2+ release channels in longitudinal muscle of intestine. ( Kuemmerle, JF; Makhlouf, GM; Murthy, KS, 1994)
"Anaesthesia-induced malignant hyperthermia (MH) may be caused by specific gene defects in the skeletal muscle ryanodine receptor."	1.29	Genotype and phenotype relationships for mutations in the ryanodine receptor in patients referred for diagnosis of malignant hyperthermia. ( Fletcher, JE; Hubert, M; Levitt, RC; Rosenberg, H; Tripolitis, L; Vita, GM, 1995)
"Caffeine contractures were induced after K(+)-conditioning of skeletal muscles from pigs and mice."	1.29	Modulation of caffeine contractures in mammalian skeletal muscles by variation of extracellular potassium. ( Gallant, EM; Lentz, LR; Taylor, SR, 1995)
"Jatrophone was equipotent to H-7, but 100 to 500 fold less potent than staurosporine."	1.29	The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors. ( Brum, RL; Calixto, JB; Silva, AM, 1995)
"A 3% halothane-induced increase in [Ca2+]cyt was observed in the Ca(2+)-free solution even when the muscle strip was pretreated with a 10(-6)-M dose of ryanodine and a 20-mM dose of caffeine, whereas it was abolished completely after the muscle strip was pretreated with ryanodine, caffeine, and 100 nM norepinephrine."	1.29	Effects of halothane and isoflurane on cytosolic calcium ion concentrations and contraction in the vascular smooth muscle of the rat aorta. ( Fujita, S; Namba, H; Namiki, A; Notsuki, E; Tsuchida, H; Yamakage, M, 1993)
"Pretreatment with tetrodotoxin (0."	1.29	Studies on the contracture inducing action of triphenyltin in the mouse diaphragm. ( Liu, SH; Shiau, SY, 1994)
"Caffeine inhibited the increase in the resting tone without blocking the refilling process of the stores at 37 degrees C, but at 25 degrees C a partial inhibition of the repletion of internal Ca2+ pools was observed."	1.29	Effects of different agents on the contractile response elicited by extracellular calcium after depletion of internal calcium stores in rat isolated aorta. ( D'Ocon, MP; Noguera, MA, 1993)
"When papaverine was washed out, a second application of 10(-4) M histamine also induced transient increases in [Ca2+]i and force."	1.29	Relationship between cytosolic calcium concentration and force in the papaverine-induced relaxation of medial strips of pig coronary artery. ( Aoki, H; Kanaide, H; Kobayashi, S; Nishimura, J, 1994)
"Pretreatment with verapamil (1 or 10 microM), nifedipine (0."	1.29	The effects of phorbol 12,13-diacetate on responses of guinea-pig isolated trachea to methylxanthines, isoprenaline and ryanodine. ( Cortijo, J; Morcillo, EJ; Sanz, CM; Small, RC; Villagrasa, V, 1994)
"Caffeine (100 mM) was shown to discharge Ca2+ in the SR, and cyclopiazonic acid (CPA, 10 microM) was shown to inhibit the Ca2+ uptake into the SR in these arteries."	1.29	Handling of cytoplasmic Ca2+ by the sarcoplasmic reticulum during alpha 1-adrenoceptor-mediated contraction of rat mesenteric resistance arteries. ( Ito, K; Naganobu, K, 1994)
"Dantrolene failed to inhibit the caffeine- and CCh-induced contractions depending on intracellularly stored Ca."	1.29	Inhibitory effects of dantrolene on contractile responses in gastric smooth muscle of the rat. ( Ito, S; Nakazato, Y; Ohta, T; Satoh, K, 1994)
"Enflurane has similar mechanisms of action in aorta and femoral artery: blocking Ca2+ influx, and causing, at least in part, Ca2+ release from the sarcoplasmic reticulum through the ryanodine-receptor channel."	1.29	Mechanisms of action of enflurane on vascular smooth muscle. Comparison of rabbit aorta and femoral artery. ( Chang, YI; Su, JY; Tang, LJ, 1994)
"Pretreatment with ryanodine caused a more potent dose-dependent inhibition of 10 mM caffeine-induced contractions in SHR than in WKY."	1.29	Ryanodine-induced contraction in femoral artery from spontaneously hypertensive rats. ( Dohi, Y; Kojima, M; Sato, K, 1994)
"1."	1.29	The effect of caffeine on the contractile response of the rabbit urinary bladder to field stimulation. ( Lee, JG; Levin, RM; Wein, AJ, 1993)
" PE shifted the ouabain dose-response curve toward lower ouabain concentrations; conversely, ouabain shifted the PE dose-response curve toward lower PE concentrations."	1.29	Nanomolar ouabain augments caffeine-evoked contractions in rat arteries. ( Blaustein, MP; Heidrich, J; Podberesky, DJ; Weiss, DN, 1993)
"Caffeine caused an increase in force only in < 20 Hz, but a decrease in 50 and 100 Hz."	1.29	The effects of theophylline and caffeine on the isolated rat diaphragm. ( Gölgeli, A; Ozesmi, C; Ozesmi, M, 1995)
"Isoflurane may cause differential effects on different vascular beds of the same animal species."	1.29	Mechanisms of action of isoflurane on contraction of rabbit conduit artery. ( Su, JY, 1996)
"The caffeine threshold was lowered by Mg2+, K+, 0 ."	1.29	Caffeine-evoked contractures in single slow (tonic) muscle fibres of the frog (Rana temporaria and R. esculenta). ( Hoock, C; Schmidt, H; Steinmetz, J, 1996)
"Caffeine sensitivity was defined as the threshold concentration inducing > 10% of the maximal tension obtained after the fiber was loaded with a 1."	1.29	In vitro human masseter muscle hypersensitivity: a possible explanation for increase in masseter tone. ( Adnet, PJ; Etchrivi, T; Haudecoeur, G; Krivosic, I; Krivosic-Horber, R; Reyford, H; Tavernier, BM, 1996)
"Glycerol treatment only reduced, but did not eliminate twitches developed by muscles 7 days after injection."	1.29	External calcium dependence of extensor digitorum longus muscle contractility during bupivacaine-induced regeneration. ( Fichter-Gagnepain, V; Louboutin, JP; Noireaud, J, 1996)
"3."	1.29	Major difference between rat and guinea-pig ureter in the ability of agonists and caffeine to release Ca2+ and influence force. ( Burdyga, TV; Taggart, MJ; Wray, S, 1995)
"Aclarubicin pretreatment attenuated phorbol 12, 13-dibutyrate (1 microM)-induced contraction both in the presence and absence of calcium in the medium."	1.29	Mechanisms in inhibitory action of aclarubicin on contractility of rat aorta. ( Hatake, K; Masui, H; Sakamoto, K; Wakabayashi, I, 1995)
"When hirsutine was added at 30 microM before caffeine treatment, the agent slightly but significantly reduced the caffeine-induced contraction."	1.28	Effects of hirsutine, an antihypertensive indole alkaloid from Uncaria rhynchophylla, on intracellular calcium in rat thoracic aorta. ( Aimi, N; Horie, S; Sakai, S; Watanabe, K; Yano, S, 1992)
"The defect in malignant hyperthermia (MH) alters the binding of [3H]ryanodine to the Ca(2+)-release channel by increasing its apparent affinity for the binding site."	1.28	[3H]ryanodine as a probe of changes in the functional state of the Ca(2+)-release channel in malignant hyperthermia. ( Hamilton, SL; Hawkes, MJ; Nelson, TE, 1992)
"3."	1.28	Mechanisms of caffeine-induced contraction and relaxation of rat aortic smooth muscle. ( Hirano, K; Kanaide, H; Kobayashi, S; Watanabe, C; Yamamoto, H, 1992)
"1."	1.28	W-7, a calmodulin antagonist, and contracture of malignant hyperthermia susceptible skeletal muscle. ( Holland, M; Lee, JC; Williams, JH, 1992)
"2."	1.28	Propofol anaesthesia in malignant hyperpyrexia susceptible swine. ( Denborough, MA; Foster, PS; Hopkinson, KC, 1992)
"2."	1.28	Effects of ruthenium red on excitation and contraction in muscle fibres with Ca2+ electrogenesis. ( Hencek, M; Lipskaja, E; Pavelková, J; Uhrík, B; Zacharová, D, 1990)
"Cromakalim was a much more effective inhibitor of these contractions (maximum inhibition by 80%, midpoint of the inhibition curve at 171 +/- 15 nM)."	1.28	Cromakalim inhibits contractions of the rat isolated mesenteric bed induced by noradrenaline but not caffeine in Ca(2+)-free medium: evidence for interference with receptor-mediated Ca2+ mobilization. ( Baumlin, Y; Quast, U, 1991)
"Until our malignant hyperthermia diagnostic center was opened, such tests could not be performed in Israel."	1.28	[In vitro diagnosis of malignant hyperpyrexia syndrome]. ( Eldar, I; Glauber, V; Goldberg, G; Perel, A, 1991)
" In the presence of [Mg2+]o, substitution of foreign anions resulted in alterations in the agonist contractile dose-response curves; EC50s were increased whereas maximum tensions were depressed."	1.28	Interactions of magnesium and chloride ions on tone and contractility of vascular muscle. ( Altura, BM; Altura, BT; Carella, A; Zhang, A, 1991)
"Pretreatment with formamide (2 M for 30 min) abolished contractile Ca2+ transients, but did not affect non-contractile ones."	1.28	Reversed effect of caffeine on non-contractile and contractile Ca2+ mobilization operated by acetylcholine receptor in mouse diaphragm muscle. ( Kimura, I; Kimura, M; Kondoh, T; Tsuneki, H, 1991)
"Urea was less effective; only after hypertonic treatment with 800 mM were contractions of rat soleus muscle abolished at 37 degrees C, while at the lower temperature contractions could not be abolished."	1.28	Contraction of rat soleus muscle and the effects of hypertonic treatments. ( Bruton, JD, 1991)
"Caffeine was able to induce contracture even in muscles soaked in "zero" Ca2+ solution for 24 to 48 h."	1.28	Changes in contractile force by barium in the frog skeletal muscle. ( Hatae, J; Kawata, H, 1990)
"3."	1.28	Tyramine antagonizes proctolin-induced contraction of the isolated foregut of the locust Schistocerca gregaria by an interaction with octopamine2 receptors. ( Banner, SE; Cattell, KJ; Osborne, RH; Wood, SJ, 1990)
"The inheritance of malignant hyperthermia susceptibility is thought to be autosomal dominant and the incidence could be as high as 1:10,000."	1.28	[Diagnosis of susceptibility for malignant hyperthermia using in-vitro muscle contraction testing in Switzerland]. ( Censier, K; Drewe, J; Frei, F; Rothenbühler, JM; Seeberger, MD; Urwyler, A, 1991)
"Caffeine sensitivity was studied in chemically skinned muscle fibers from vastus lateralis muscle obtained by biopsy during reconstructive knee surgery from 15 otherwise healthy young individuals."	1.28	Fiber-type specific caffeine sensitivities in normal human skinned muscle fibers. ( Andrish, JT; Bunge, G; Cruse, RP; DeBoer, GE; Mitsumoto, H; Tetzlaff, JE, 1990)
"Caffeine contracture was inhibited by the calcium antagonists at 20 degrees C."	1.28	Dependence of contractile responses by some calcium antagonists on external calcium in the skeletal muscle. ( Hatae, J; Kawata, H, 1990)
" Acute and chronic administration of Chlo (45 mg kg-1, i."	1.28	Mode of inhibitory actions of acute and chronic chloroquine administration on the electrically stimulated mouse diaphragm in vitro. ( Okwuasaba, FK; Otubu, JA; Udoh, FV, 1990)
"When histamine or caffeine was repetitively applied in Ca2(+)-free medium, the first application produced an increase in Ca2+i but the second application produced no increase."	1.28	Histamine increases vascular tone and intracellular calcium level using both intracellular and extracellular calcium in porcine coronary arteries. ( Mori, T; Taira, N; Yanagisawa, T, 1990)
" The dose-response curve for the halothane-induced contractures of Ca2(+)-loaded skinned fibers was displaced to the left after denervation."	1.28	Alterations in the functional properties of skinned fibers from denervated rabbit skeletal muscle. ( Suarez-Kurtz, G; Sudo, RT; Trachez, MM, 1990)
"Midazolam is a water soluble benzodiazepine of interest to the anaesthetist for use as a premedicant and for induction of anaesthesia."	1.27	Effects of midazolam on directly stimulated muscle biopsies from control and malignant hyperthermia positive patients. ( Fletcher, JE; Hilf, M; Rosenberg, H, 1984)
"Enflurane enhanced the increase of light signal observed in rapid cooling contracture."	1.27	Effects of enflurane on excitation-contraction coupling in frog skeletal muscle fibers. ( Konishi, M; Kurihara, S; Miyagishima, T; Sakai, T, 1984)
"The caffeine test was positive in 68% of MHS patients, 0."	1.27	Investigation of malignant hyperthermia in Denmark and Sweden. ( Fletcher, R; Ording, H; Ranklev, E, 1984)
"A European Malignant Hyperpyrexia Group has been formed to facilitate exchange of information between centres performing in vitro muscle testing for malignant hyperpyrexia susceptibility."	1.27	A protocol for the investigation of malignant hyperpyrexia (MH) susceptibility. The European Malignant Hyperpyrexia Group. ( , 1984)
"Procaine is a substance which is known to specifically inhibit the calcium-induced calcium release mechanism."	1.27	Effects of procaine on the isolated dog coronary artery. ( Imai, H; Imai, S; Nabata, H; Nakazawa, M, 1984)
" The dose-response curve of caffeine contracture in the fatigued fibers was shifted toward the right; the threshold concentration of caffeine for the contracture in normal fibers was 1."	1.27	Properties of caffeine- and potassium-contractures in fatigued frog single twitch muscle fibers. ( Kanaya, H; Nagai, T; Takauji, M, 1983)
"Diltiazem and verapamil were equipotent and were about 10 and 30 times more potent than tetracaine and MnCl2 on a weight basis."	1.27	Mechanisms of slow contracture induced by potassium and caffeine in skeletal muscle of the dog. ( Aoyama, T; Ono, H; Sato, T, 1984)
"Caffeine was also found to suppress the low-Na contracture of Na-loaded ureter muscle."	1.27	Effects of caffeine on the electrical and mechanical activity of guinea-pig ureter smooth muscle. ( Burdyga, TV; Magura, IS, 1986)
"Caffeine may inhibit noradrenalineinduced Ca2' release."	1.27	Inhibitory effects of caffeine on contractions and calcium movement in vascular and intestinal smooth muscle. ( Ahn, HY; Karaki, H; Urakawa, N, 1988)
"The halothane-induced increase in [Ca2+]i required extracellular calcium ions."	1.27	Anaesthetic-induced increase in ionised calcium in blood mononuclear cells from malignant hyperthermia patients. ( Britt, BA; Elliott, ME; Frodis, W; Klip, A; Pegg, W; Scott, E, 1987)
"adenosine were significantly less than -1 unless the adenosine reuptake blocker dipyridamole (0."	1.27	Effects of caffeine and 8-phenyltheophylline on the actions of purines and opiates in the guinea-pig ileum. ( Ahlijanian, MK; Takemori, AE, 1986)
"Trapezius muscle from normal and malignant hyperthermia (MH) pigs was used to investigate the effects of halothane on contractile properties and on the calcium transport system of isolated surface membranes."	1.27	Effect of halothane on the Ca2+-transport system of surface membranes isolated from normal and malignant hyperthermia pig skeletal muscle. ( Kozak-Reiss, G; Rock, E, 1987)
"Caffeine-induced spasm was attenuated in a Ca2+-free medium containing EGTA (2 mM), modestly at first but subsequently more profoundly."	1.27	The relaxant and spasmogenic effects of some xanthine derivatives acting on guinea-pig isolated trachealis muscle. ( Boyle, JP; Cortijo, J; Curtis-Prior, PB; Davies, JM; Foster, RW; Hofer, P; Small, RC, 1988)
"When ryanodine was applied during Ca deprivation, the rate of the decrease was remarkably accelerated."	1.27	Ryanodine: its possible mechanism of action in the caffeine-sensitive calcium store of smooth muscle. ( Hisayama, T; Takayanagi, I, 1988)
"Glycerol treatment (0."	1.27	The effect of lithium and nitrate on potassium contractures in a glycerol-treated slow-twitch muscle of the rat. ( Bruton, JD, 1988)
"Caffeine contractures were recorded from thin bundles and whole extensor digitorum longus (EDL) and soleus muscles of rat, and correlated with preparation size and fiber types."	1.27	Effect of fiber types, fascicle size and halothane on caffeine contractures in rat muscles. ( Pagala, MK; Sahgal, V; Shah, AJ; Subramani, V; Venkatachari, SA, 1988)
"Caffeine also has an inhibitory effect which is partly attributable to decrease in [Ca2+]cyt and partly to the decrease in the sensitivity to Ca2+ of the contractile elements."	1.27	Multiple effects of caffeine on contraction and cytosolic free Ca2+ levels in vascular smooth muscle of rat aorta. ( Karaki, H; Ozaki, H; Sato, K, 1988)
"Glycerol treatments reduced but did not abolish twitch, tetanus, and potassium contracture tension and these changes were far less at 22 than at 37 degrees C."	1.27	Contraction of rat skeletal muscle after glycerol treatments. ( Bruton, JD, 1988)
"1."	1.27	Calmodulin-antagonist drugs and porcine malignant hyperpyrexia. ( Collins, SP; Denborough, MA; White, MD, 1988)
"The association of malignant hyperthermia (MH) with neuromuscular disorders has been recognized since 1970."	1.27	Halothane-caffeine contracture testing in neuromuscular diseases. ( Fletcher, JE; Heiman-Patterson, TD; Rosenberg, H; Tahmoush, AJ, 1988)
"The acute malignant hyperthermia crisis appears to be mediated by a sudden and sustained rise in the concentration of sarcoplasmic calcium, leading to a prolonged muscle contraction."	1.27	Abnormal relaxation rates in subjects susceptible to malignant hyperthermia. ( Henriksson, KG; Lennmarken, C; Rutberg, H, 1987)
"In vitro tests for the diagnosis of malignant hyperthermia susceptibility were performed in 105 patients and 20 normal controls according to the protocol of the European MH Group."	1.27	In vitro diagnosis of susceptibility to malignant hyperthermia: comparison between dynamic and static halothane and caffeine tests. ( Ording, H; Skovgaard, LT, 1987)
" The extent of overlap for the different calcium pools between the various agonists was determined by studying the dose-response relationships of these agents before and after pretreatment with another agonist, i."	1.27	Agonist interactions at the calcium pools in skinned and unskinned canine tracheal smooth muscle. ( Davis, C; Kannan, L; Kannan, MS; Ladenius, AR, 1987)
"Caffeine sensitivity was greatest at stages 26-28, then appeared to decline at stages 33-36."	1.27	Contractile activation in myotomes from developing larvae of Xenopus laevis. ( Huang, CL, 1986)
"To diagnose malignant hyperthermia susceptibility (MHS), caffeine and halothane contracture tests were performed on six patients."	1.27	[Detection of peranesthetic malignant hyperthermia by muscle contracture tests and NMR spectroscopy]. ( Gascard, JP; Kozak-Reiss, G; Redouane-Bénichou, K, 1986)
"Ten additional patients had other muscle disorders (central core disease, hyperkalemic periodic paralysis, and Duchenne's muscular dystrophy) and abnormal IVCTs; six of the ten had elevated CK levels."	1.27	Serum creatine kinase level as a screening test for susceptibility to malignant hyperthermia. ( Brownell, AK; Paasuke, RT, 1986)
"The caffeine-induced increase in Ca2+-aequorin luminescence was inhibited by GLR, but not by PF."	1.27	Decreasing effects by glycyrrhizin and paeoniflorin on intracellular Ca2+-aequorin luminescence transients with or without caffeine in directly stimulated-diaphragm muscle of mouse. ( Kimura, I; Kimura, M, 1985)
"Caffeine contracture was not affected by RR."	1.26	Effect of ruthenium red on excitation-contraction coupling in frog skeletal muscle. ( Nagai, T; Obara, K; Suzuki, T, 1980)
"When quercetin was added together with initiators of tension development, however, the rate of tension development was enhanced 4- to 7-fold and the relaxation rate of the fibers was greatly inhibited."	1.26	Quercetin inhibits Ca2+ uptake but not Ca2+ release by sarcoplasmic reticulum in skinned muscle fibers. ( Britt, BA; Campbell, KP; Frodis, W; MacLennan, DH; Shoshan, V, 1980)
"It is proposed that muscle relaxation is a two step process: an initial step that is regulated by the rate of Ca2+ uptake by sarcoplasmic reticulum, and a later step that is mostly controlled by the speed of dissociation of remaining cross-bridges."	1.26	Effect of length and caffeine on isometric tetanus relaxation of frog sartorius muscles. ( Pagala, MK, 1980)
"In caffeine-treated muscle fibres, electrically produced depolarization could initiate or increase the frequency of sarcomeric oscillations, and electrical hyperpolarization diminishes the frequency or stops sarcomeric oscillations."	1.26	Action of caffeine in excitation-contraction coupling of frog skeletal muscle fibres. ( Kumbaraci, NM; Nastuk, WL, 1982)
"Pre-treatment with procaine blocked both the contractures and the increased enzyme loss induced by these alkaloids."	1.26	Caffeine and quinine increase the release of sarcoplasmic enzymes from frog skeletal muscles. ( Suarez-Kurtz, G, 1982)
"Caffeine is found to be a more efficient releaser of cellular Ca than noradrenaline."	1.26	General features of electrical and mechanical properties of smooth muscle cells in the guinea-pig abdominal aorta. ( Kajiwara, M, 1982)
" Dantrolene sodium, verapamil and nifedipine were able to shift the dose-response curves of calcium in potassium-polarized rabbit jejunum to the right and pA2 values were found to be 4."	1.26	Effect of dantrolene sodium on the contractility of rabbit jejunum in vitro. ( Dehpour, AR; Mahmoudian, M; Mofakham, S, 1981)
"In this Research Conference we define malignant hyperthermia, present its brief history, and describe the diagnostic procedures and directions of research in our laboratory."	1.26	Malignant hyperthermia: diagnosis, treatment and investigations of a skeletal muscle lesion. ( Flewellen, EH; Nelson, TE, 1979)
"Caffeine contracture was inhibited in the muscle with a previous elicitation of CTX contracture."	1.26	Mechanism of action of cobra cardiotoxin in the skeletal muscle. ( Huang, MC; Lee, CY; Lin Shiau, SY, 1976)
"Caffeine contracture was partially inhibited by dantrolene and was almost unchanged by it in potassium-depolarized muscele fiber."	1.25	Effect of dantrolene sodium on excitation-contraction coupling in frog skeletal muscle. ( Nagai, T; Takahashi, N; Takauji, M, 1975)
"Animals died from a characteristic spastic paralysis after intravenous injection of the toxin."	1.25	A myotoxin secreted by some piscivorous Conus species. ( Freeman, SE; Turner, RJ, 1972)
" Procaine administered in a dosage (5 x 10(-3) W/V)which would suppress the contracture due to caffeine (10 mM), did not modify the tension developed during the hyperpolarization."	1.25	Muscle contraction during hyperpolarizing currents in the crab. ( García, H; Uchitel, OD, 1974)
"Tetracaine, 0."	1.25	The action of caffeine on the activation of the contractile mechanism in straited muscle fibres. ( Lüttgau, HC; Oetliker, H, 1968)
"The glycerol treatment results in a depression of the resting potential of up to 30 mV."	1.25	A lesion of the transverse tubules of skeletal muscle. ( Howell, JN, 1969)

Timeframe	Studies, this research(%)	All Research%
pre-1990	747 (50.13)	18.7374
1990's	437 (29.33)	18.2507
2000's	211 (14.16)	29.6817
2010's	80 (5.37)	24.3611
2020's	15 (1.01)	2.80

Trial	Enrollment	Study Type	Start Date	Status
The Effect of Caffeine Supplementation on Blood Lactate Level, Performance and Post-Training Fatigue in Elite Basketball Players[NCT05916352]	50 participants (Actual)	Interventional	2022-07-04	Completed
H-reflex Measurement in Hemiplegic Stroke Patients[NCT04977531]	60 participants (Anticipated)	Observational	2021-08-01	Not yet recruiting
Freeman-Sheldon Syndrome Evaluation and Diagnosis in Clinical Settings (FSS-EDICT) I: a Case-Control, Cross-Sectional Study of Baseline and Stress Physiology Parameters[NCT01306994]	0 participants (Actual)	Observational	2014-03-31	Withdrawn (stopped due to Lack of patient interest)
Implication of Patient in the Making Ready of Recommendations for the Antivitamin K's Gestion in Case of Thrombosis Embolic Venous's Illness. Randomised Study for Clinical Validation.[NCT00227097]	300 participants	Observational	2002-12-31	Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Experimental biology and medicine (Maywood, N.J.), 2022, Volume: 247, Issue:7 Topics: Baths; Caffeine; Humans; In Vitro Techniques; Laboratories; Malignant Hyperthermia; Muscle Contracti	2022
Effect of Caffeine Supplementation on Sports Performance Based on Differences Between Sexes: A Systematic Review. Nutrients, 2019, Sep-30, Volume: 11, Issue:10 Topics: Adult; Caffeine; Dietary Supplements; Female; Humans; Male; Middle Aged; Muscle Contraction; Muscle	2019
Clinical protocol for the management of malignant hyperthermia. Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:1 Topics: Adolescent; Adult; Caffeine; Calcium Signaling; Child; Child, Preschool; Clinical Protocols; Critica	2017
Methylxanthines and ryanodine receptor channels. Handbook of experimental pharmacology, 2011, Issue:200 Topics: Animals; Caffeine; Calcium; Endoplasmic Reticulum; Humans; Muscle Contraction; Neurons; Neurotransmi	2011
POTENTIATION OF MUSCULAR CONTRACTION. Archives of physical medicine and rehabilitation, 1964, Volume: 45 Topics: Animals; Anura; Bromides; Cadmium; Caffeine; Electrophysiology; Epinephrine; Humans; Iodides; Iodine	1964
Caffeine: a valuable tool to study central fatigue in humans? Exercise and sport sciences reviews, 2004, Volume: 32, Issue:4 Topics: Caffeine; Central Nervous System Stimulants; Evoked Potentials, Motor; Exercise; Fatigue; Humans; Mo	2004
The influence of caffeine on voluntary muscle activation. Medicine and science in sports and exercise, 2005, Volume: 37, Issue:12 Topics: Caffeine; Central Nervous System; Evoked Potentials; Humans; Motor Activity; Muscle Contraction; Mus	2005
Caffeine use in sports, pharmacokinetics in man, and cellular mechanisms of action. Critical reviews in food science and nutrition, 2005, Volume: 45, Issue:7-8 Topics: Caffeine; Central Nervous System; Energy Metabolism; Female; Half-Life; Humans; Intestinal Absorptio	2005
[Anesthesia in malignant hyperthermia]. Revista espanola de anestesiologia y reanimacion, 2008, Volume: 55, Issue:3 Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Caffeine; Calcium Signaling; Child; Child, Prescho	2008
Cellular calcium mobilization. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 4 Topics: Animals; Caffeine; Calcium; Calcium Radioisotopes; Female; Guinea Pigs; In Vitro Techniques; Ion Cha	1984
Effects of methylxanthines on skeletal muscle and on respiration. Progress in clinical and biological research, 1984, Volume: 158 Topics: Animals; Caffeine; Histamine Release; Muscle Contraction; Muscles; Respiration; Theobromine; Theophy	1984
Malignant hyperthermia. Biochemical pharmacology, 1983, Aug-01, Volume: 32, Issue:15 Topics: Animals; Caffeine; Calcium; Cold Temperature; Creatine Kinase; Dantrolene; Disease Susceptibility; H	1983
Calcium exchange hypothesis of skeletal muscle fatigue: a brief review. Muscle & nerve, 1995, Volume: 18, Issue:4 Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Caffeine; Calcium; Fatty A	1995
Caffeine and sports activity: a review. International journal of sports medicine, 1994, Volume: 15, Issue:5 Topics: Caffeine; Central Nervous System; Humans; Muscle Contraction; Muscles; Physical Exertion; Receptors,	1994
Caffeine and excitation-contraction coupling in skeletal muscle: a stimulating story. Journal of muscle research and cell motility, 1999, Volume: 20, Issue:2 Topics: Animals; Caffeine; Calcium; Humans; Models, Biological; Muscle Contraction; Muscle, Skeletal; Ryanod	1999
[Relationship between neuromuscular transmission and active amines--electromyographic informations]. Nihon rinsho. Japanese journal of clinical medicine, 1975, Volume: 33, Issue:10 Topics: Acetylcholine; Animals; Biogenic Amines; Caffeine; Calcium; Cats; Cyclic AMP; Dopamine; Electromyogr	1975
Analysis of living tissue by phosphorus-31 magnetic resonance. Science (New York, N.Y.), 1977, Jan-14, Volume: 195, Issue:4274 Topics: Adenosine Triphosphate; Animals; Caffeine; Chickens; Humans; Magnetic Resonance Spectroscopy; Muscle	1977
Epidemiology and inheritance of malignant hyperthermia. International anesthesiology clinics, 1979,Winter, Volume: 17, Issue:4 Topics: Adenosine Triphosphate; Caffeine; Creatine Kinase; Female; Genetic Predisposition to Disease; Haloth	1979
Preanesthetic diagnosis of malignant hyperthermia. International anesthesiology clinics, 1979,Winter, Volume: 17, Issue:4 Topics: Adenosine Triphosphate; Caffeine; Cardiac Catheterization; Creatine Kinase; Halothane; Heart; Humans	1979
Calcium release from the sarcoplasmic reticulum. Circulation research, 1977, Volume: 40, Issue:2 Topics: Animals; Anura; Caffeine; Calcium; Egtazic Acid; Muscle Contraction; Muscle, Smooth; Muscles; Myocar	1977
Excitation-contraction coupling mechanism in visceral smooth muscle. Advances in biophysics, 1976, Volume: 8 Topics: Animals; Caffeine; Calcium; Cats; Cell Membrane Permeability; Cold Temperature; Dogs; Electric Condu	1976
Excitation-contraction coupling. Annual review of physiology, 1976, Volume: 38 Topics: Action Potentials; Animals; Caffeine; Calcium; Dantrolene; Deuterium; Electric Stimulation; Formalde	1976
Contractile activation in skeletal muscle. Progress in biophysics and molecular biology, 1975, Volume: 29, Issue:2 Topics: Action Potentials; Animals; Caffeine; Calcium; Cell Membrane Permeability; Dantrolene; Formaldehyde;	1975
Ca2+ channels and excitation-contraction coupling. Current opinion in cell biology, 1991, Volume: 3, Issue:4 Topics: Action Potentials; Animals; Caffeine; Calcium; Calcium Channels; CHO Cells; Cricetinae; Dihydropyrid	1991
Caffeine, neuromuscular function and high-intensity exercise performance. The Journal of sports medicine and physical fitness, 1991, Volume: 31, Issue:3 Topics: Caffeine; Central Nervous System; Exercise; Humans; Muscle Contraction; Neuromuscular Junction; Phys	1991
Malignant hyperthermia: relation to other diseases. Acta anaesthesiologica Belgica, 1990, Volume: 41, Issue:2 Topics: Caffeine; Calcium Channels; Diagnosis, Differential; Halothane; Humans; Malignant Hyperthermia; Musc	1990
Properties of calcium release channels of the intracellular calcium store in muscle cells. Advances in second messenger and phosphoprotein research, 1990, Volume: 24 Topics: Animals; Caffeine; Calcium; Calcium Channels; Cell Compartmentation; Inositol 1,4,5-Trisphosphate; I	1990
Calcium-gated calcium channels in sarcoplasmic reticulum of rabbit skinned skeletal muscle fibers. The Journal of general physiology, 1986, Volume: 87, Issue:2 Topics: Animals; Biological Transport, Active; Caffeine; Calcium; In Vitro Techniques; Ion Channels; Muscle	1986
Pharmacological studies of excitation-contraction coupling in skeletal muscle. Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:4 Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Gallic Acid; Ion Channels; Muscle Contraction;	1987
Mechanisms of excitation-contraction coupling in skinned muscle fibers. Medicine and science in sports and exercise, 1989, Volume: 21, Issue:4 Topics: Animals; Caffeine; Calcium; Muscle Contraction; Muscles; Rabbits; Sarcomeres	1989
Standardization of the caffeine halothane muscle contracture test. North American Malignant Hyperthermia Group. Anesthesia and analgesia, 1989, Volume: 69, Issue:4 Topics: Biopsy; Caffeine; Clinical Laboratory Techniques; Disease Susceptibility; Halothane; Humans; Maligna	1989
Calcium-induced calcium release mechanism in vascular smooth muscles--assessments based on contractions evoked in intact and saponin-treated skinned muscles. Experientia, 1985, Aug-15, Volume: 41, Issue:8 Topics: Animals; Caffeine; Calcium; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP; Glycerol; In Vi	1985
Diagnosis of susceptibility to malignant hyperthermia in man. British journal of anaesthesia, 1988, Volume: 60, Issue:3 Topics: Caffeine; Chemistry, Clinical; Disease Susceptibility; Halothane; Hematologic Tests; Humans; In Vitr	1988
Pharmacotherapy of respiratory muscles. Clinics in chest medicine, 1988, Volume: 9, Issue:2 Topics: Animals; Caffeine; Humans; Muscle Contraction; Respiratory Insufficiency; Respiratory Muscles; Stimu	1988
Effect of anaesthetics on intracellular calcium ions in muscle. Life sciences, 1986, Apr-21, Volume: 38, Issue:16 Topics: Anesthetics; Animals; Biological Transport, Active; Caffeine; Calcium; Muscle Contraction; Muscles;	1986
Rapid cooling contracture. The Japanese journal of physiology, 1986, Volume: 36, Issue:3 Topics: Animals; Biomechanical Phenomena; Caffeine; Calcium; Cold Temperature; Hydrogen-Ion Concentration; I	1986
Calcium movements in relation to contraction. Biochemical Society symposium, 1974, Issue:39 Topics: Aequorin; Animals; Biological Transport, Active; Caffeine; Calcium; Egtazic Acid; Kinetics; Light; M	1974
Ca ions and excitation-contraction coupling in heart muscle. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1973, Volume: 35, Issue:3 Topics: Action Potentials; Adenosine Triphosphatases; Animals; Caffeine; Calcium; Cattle; Electric Conductiv	1973
[Temperature and activity of the smooth muscle--with special reference to effects of temperature on contraction and ion transfer]. Nihon Heikatsukin Gakkai zasshi, 1971, Volume: 7, Issue:4 Topics: Acetylcholine; Actomyosin; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Anura; Caffei	1971
The positive inotropic effect of cyclic AMP. Advances in cyclic nucleotide research, 1972, Volume: 1 Topics: Aminophylline; Animals; Butyrates; Caffeine; Cyclic AMP; Epinephrine; Glucagon; Guinea Pigs; Heart;	1972
[Rapid cooling contracture]. Nihon Heikatsukin Gakkai zasshi, 1972, Volume: 8, Issue:3 Topics: Animals; Anura; Bufonidae; Caffeine; Calcium; Cocaine; Cold Temperature; Depression, Chemical; Endop	1972
Malignant hyperpyrexia. British journal of anaesthesia, 1973, Volume: 45, Issue:3 Topics: Adenosine Triphosphate; Anesthesia, General; Animals; Bicarbonates; Caffeine; Creatine Kinase; Glyco	1973
[Current methods of drug therapy of a threatened premature labor (review of literature)]. Voprosy okhrany materinstva i detstva, 1968, Volume: 13, Issue:2 Topics: Adult; Bicarbonates; Bromine; Caffeine; Ephedrine; Female; Humans; Muscle Contraction; Obstetric Lab	1968
[Excitation-contraction coupling in the skeletal muscle]. Nihon Heikatsukin Gakkai zasshi, 1969, Volume: 5, Issue:3 Topics: Action Potentials; Animals; Anura; Caffeine; Calcium; Electric Stimulation; In Vitro Techniques; Mus	1969

Article	Year
Caffeine Increases Endurance Performance via Changes in Neural and Muscular Determinants of Performance Fatigability. Medicine and science in sports and exercise, 2022, 09-01, Volume: 54, Issue:9 Topics: Bicycling; Caffeine; Double-Blind Method; Fatigue; Humans; Male; Muscle Contraction; Muscle Fatigue	2022
Caffeine Supplementation Improves Anaerobic Performance and Neuromuscular Efficiency and Fatigue in Olympic-Level Boxers. Nutrients, 2019, Sep-05, Volume: 11, Issue:9 Topics: Boxing; Caffeine; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Humans; Male; Muscle	2019
Effects of caffeine on neuromuscular function in a non-fatigued state and during fatiguing exercise. Experimental physiology, 2020, Volume: 105, Issue:4 Topics: Adult; Caffeine; Double-Blind Method; Evoked Potentials, Motor; Exercise; H-Reflex; Humans; Male; Mo	2020
Caffeine improves performance but not duration of the countermovement jump phases. The Journal of sports medicine and physical fitness, 2021, Volume: 61, Issue:2 Topics: Adult; Athletic Performance; Caffeine; Cross-Over Studies; Double-Blind Method; Humans; Male; Muscle	2021
Caffeine-Induced Effects on Human Skeletal Muscle Contraction Time and Maximal Displacement Measured by Tensiomyography. Nutrients, 2021, Mar-02, Volume: 13, Issue:3 Topics: Adult; Athletes; Caffeine; Double-Blind Method; Electromyography; Humans; Male; Muscle Contraction;	2021
The Effects of Caffeine on Jumping Performance and Maximal Strength in Female Collegiate Athletes. Nutrients, 2021, Jul-22, Volume: 13, Issue:8 Topics: Adolescent; Athletes; Athletic Performance; Caffeine; Cross-Over Studies; Double-Blind Method; Femal	2021
The Effect of Acute Taurine Ingestion on Human Maximal Voluntary Muscle Contraction. Medicine and science in sports and exercise, 2018, Volume: 50, Issue:2 Topics: Adult; Caffeine; Double-Blind Method; Humans; Male; Muscle Contraction; Muscle Strength; Muscle, Ske	2018
Effect of caffeine ingestion on torque and muscle activity during resistance exercise in men. Muscle & nerve, 2014, Volume: 50, Issue:4 Topics: Analysis of Variance; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double-Blind	2014
Co-ingestion of caffeine and carbohydrate after meal does not improve performance at high-intensity intermittent sprints with short recovery times. European journal of applied physiology, 2014, Volume: 114, Issue:7 Topics: Bicycling; Biomarkers; Blood Glucose; Caffeine; Central Nervous System Stimulants; Dietary Carbohydr	2014
Alteration in neuromuscular function of the plantar flexors following caffeine ingestion. Scandinavian journal of medicine & science in sports, 2015, Volume: 25, Issue:1 Topics: Adult; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double-Blind Method; Electro	2015
Improvements on neuromuscular performance with caffeine ingestion depend on the time-of-day. Journal of science and medicine in sport, 2015, Volume: 18, Issue:3 Topics: Body Temperature; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double-Blind Meth	2015
Effect of caffeine ingestion on maximal voluntary contraction strength in upper- and lower-body muscle groups. Journal of strength and conditioning research, 2014, Volume: 28, Issue:11 Topics: Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Humans; Lower Extremity; Male; Musc	2014
Placebo effects of caffeine on maximal voluntary concentric force of the knee flexors and extensors. Muscle & nerve, 2016, Volume: 54, Issue:3 Topics: Analysis of Variance; Caffeine; Central Nervous System Stimulants; Humans; Knee Joint; Male; Muscle	2016
Effect of two doses of caffeine on muscular function during isokinetic exercise. Medicine and science in sports and exercise, 2010, Volume: 42, Issue:12 Topics: Adult; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Exercise; Huma	2010
Effect of caffeine on self-sustained firing in human motor units. The Journal of physiology, 2002, 12-01, Volume: 545, Issue:2 Topics: Adult; Biomechanical Phenomena; Caffeine; Central Nervous System Stimulants; Electromyography; Elect	2002
Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility. European journal of anaesthesiology, 2003, Volume: 20, Issue:7 Topics: Biopsy; Caffeine; Cresols; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant	2003
Dose-dependent effect of caffeine on reducing leg muscle pain during cycling exercise is unrelated to systolic blood pressure. Pain, 2004, Volume: 109, Issue:3 Topics: Adult; Blood Pressure; Caffeine; Dose-Response Relationship, Drug; Double-Blind Method; Exercise; He	2004
Central fatigue and transcranial magnetic stimulation: effect of caffeine and the confound of peripheral transmission failure. Journal of neuroscience methods, 2004, Sep-30, Volume: 138, Issue:1-2 Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Caffeine; Central Nervous System Stimulants; E	2004
The effect of caffeine on cognitive task performance and motor fatigue. Psychopharmacology, 2005, Volume: 180, Issue:3 Topics: Adolescent; Adult; Auditory Perception; Caffeine; Central Nervous System Stimulants; Choice Behavior	2005
Central excitability does not limit postfatigue voluntary activation of quadriceps femoris. Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 100, Issue:6 Topics: Adult; Caffeine; Central Nervous System; Central Nervous System Stimulants; Double-Blind Method; Evo	2006
Increased spinal excitability does not offset central activation failure. Experimental brain research, 2006, Volume: 173, Issue:3 Topics: Action Potentials; Adult; Caffeine; Central Nervous System; Central Nervous System Stimulants; Data	2006
Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise. The journal of pain, 2007, Volume: 8, Issue:3 Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Electric Stimul	2007
Caffeine and muscle cramps: a stimulating connection. The American journal of medicine, 2007, Volume: 120, Issue:8 Topics: Caffeine; Double-Blind Method; Humans; Male; Middle Aged; Muscle Contraction; Muscle Cramp	2007
Caffeine effects on short-term performance during prolonged exercise in the heat. Medicine and science in sports and exercise, 2008, Volume: 40, Issue:4 Topics: Adult; Bicycling; Body Temperature; Caffeine; Carbohydrates; Dehydration; Double-Blind Method; Exerc	2008
Effect of caffeine on skeletal muscle function before and after fatigue. Journal of applied physiology: respiratory, environmental and exercise physiology, 1983, Volume: 54, Issue:5 Topics: Adult; Caffeine; Electric Stimulation; Humans; Muscle Contraction; Muscles; Physical Endurance; Phys	1983
Anxiety and muscle tension as consequences of caffeine withdrawal. Science (New York, N.Y.), 1980, Sep-26, Volume: 209, Issue:4464 Topics: Adult; Anxiety; Caffeine; Humans; Muscle Contraction; Substance Withdrawal Syndrome	1980
The effects of beta 2-agonists and caffeine on respiratory and limb muscle performance. The European respiratory journal, 1993, Volume: 6, Issue:8 Topics: Adrenergic beta-Agonists; Adult; Caffeine; Double-Blind Method; Female; Humans; Male; Muscle Contrac	1993
Effect of caffeine on submaximal exercise performance at altitude. Aviation, space, and environmental medicine, 1994, Volume: 65, Issue:6 Topics: Adolescent; Adult; Altitude; Caffeine; Cardiac Output; Double-Blind Method; Exercise; Exercise Test;	1994
Effects of caffeine on neuromuscular function. Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 87, Issue:2 Topics: Adult; Caffeine; Double-Blind Method; Electric Stimulation; Electromyography; Humans; Male; Motor Ne	1999
A multicenter study of 4-chloro-m-cresol for diagnosing malignant hyperthermia susceptibility. Anesthesia and analgesia, 2000, Volume: 90, Issue:1 Topics: Caffeine; Central Nervous System Stimulants; Cresols; Europe; Humans; In Vitro Techniques; Malignant	2000
Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers. Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 89, Issue:5 Topics: Adult; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double-Blind Method; Electri	2000
Genotype-phenotype comparison of the Swiss malignant hyperthermia population. Human mutation, 2001, Volume: 18, Issue:4 Topics: Caffeine; DNA Mutational Analysis; Gene Frequency; Genetic Heterogeneity; Genetic Predisposition to	2001
Opposite actions of caffeine and creatine on muscle relaxation time in humans. Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:2 Topics: Adult; Caffeine; Creatine; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Female; Hu	2002
Effect of caffeine on maximal strength and power in élite male athletes. British journal of sports medicine, 1992, Volume: 26, Issue:4 Topics: Adult; Caffeine; Double-Blind Method; Humans; Knee; Male; Muscle Contraction; Muscles; Physical Endu	1992
A blinded comparison of noninvasive, in vivo phosphorus nuclear magnetic resonance spectroscopy and the in vitro halothane/caffeine contracture test in the evaluation of malignant hyperthermia susceptibility. Anesthesia and analgesia, 1991, Volume: 72, Issue:1 Topics: Adolescent; Adult; Caffeine; Child; Child, Preschool; Disease Susceptibility; Female; Halothane; Hum	1991
Influence of caffeine on force and EMG in rested and fatigued muscle. American journal of physical medicine, 1987, Volume: 66, Issue:4 Topics: Adult; Caffeine; Double-Blind Method; Electromyography; Fatigue; Humans; Isometric Contraction; Male	1987
Caffeine ingestion and isokinetic strength. British journal of sports medicine, 1986, Volume: 20, Issue:3 Topics: Administration, Oral; Adult; Caffeine; Humans; Knee Joint; Male; Muscle Contraction	1986
Assessment of Fiorinal with Codeine in the treatment of tension headache. Clinical therapeutics, 1986, Volume: 8, Issue:6 Topics: Aspirin; Barbiturates; Caffeine; Codeine; Drug Combinations; Emotions; Headache; Humans; Muscle Cont	1986

caffeine and Muscle Contraction

Research Excerpts

Research

Studies (1,490)

Authors

Clinical Trials (4)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Alave Reyes-Furrer, A	1
De Andrade, S	1
Bachmann, D	1
Jeker, H	1
Steinmann, M	1
Accart, N	1
Dunbar, A	1
Rausch, M	1
Bono, E	1
Rimann, M	1
Keller, H	1
Cabral, DAC	1
Campos, FMS	1
Silva, MCPD	1
Medeiros, JPDV	1
Batista, PDS	1
Jardim, GC	1
Machado, JLP	1
Cabral, LGC	1
Mello, VJ	1
Hamoy, M	1
Upchurch, WJ	1
Iaizzo, PA	6
Baumann, CW	1
Ingalls, CP	4
Lowe, DA	2
Endo, Y	1
Groom, L	1
Celik, A	1
Kraeva, N	4
Lee, CS	1
Jung, SY	1
Gardner, L	1
Shaw, MA	3
Hamilton, SL	5
Hopkins, PM	7
Dirksen, RT	5
Riazi, S	4
Dowling, JJ	1
Cristina-Souza, G	1