caffeine has been researched along with Machado-Joseph Disease in 2 studies
Machado-Joseph Disease: A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Caffeine (1g/L) was applied through the drinking water." | 5.39 | Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease. ( Cunha, RA; de Almeida, LP; Gonçalves, N; Simões, AT, 2013) |
| "Machado-Joseph disease (MJD) is a neurodegenerative spinocerebellar ataxia (SCA) associated with an expanded polyglutamine tract within ataxin-3 for which there is currently no available therapy." | 1.46 | Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia. ( Cunha, RA; Gonçalves, N; Hirai, H; Pereira de Almeida, L; Prediger, RD; Simões, AT, 2017) |
| "Caffeine (1g/L) was applied through the drinking water." | 1.39 | Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease. ( Cunha, RA; de Almeida, LP; Gonçalves, N; Simões, AT, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gonçalves, N | 2 |
| Simões, AT | 2 |
| Cunha, RA | 2 |
| de Almeida, LP | 1 |
| Prediger, RD | 1 |
| Hirai, H | 1 |
| Pereira de Almeida, L | 1 |
2 other studies available for caffeine and Machado-Joseph Disease
| Article | Year |
|---|---|
Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease.
Topics: Analysis of Variance; Animals; Ataxin-3; Caffeine; CD11b Antigen; Cell Death; Corpus Striatum; Disea | 2013 |
Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.
Topics: Animals; Ataxin-3; Behavior, Animal; Caffeine; Disease Models, Animal; Humans; Machado-Joseph Diseas | 2017 |