caffeine has been researched along with Lesch-Nyhan Syndrome in 7 studies
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The inherited disease Lesch-Nyhan syndrome, which is caused by a deficiency of the enzyme hypoxanthine phosphoribosyltransferase (HPRT), is characterized by behavioural alterations, including self-injurious behaviour and mental retardation." | 7.68 | Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice. ( Melton, DW; Wu, CL, 1993) |
| "Rats ingesting high doses of caffeine reproduce the self-destructive behaviour observed in the Lesch-Nyhan syndrome." | 7.67 | Lesch-Nyhan syndrome, caffeine model: increase of purine and pyrimidine enzymes in rat brain. ( Grisolía, S; Jordá, A; Miñana, MD; Portolés, M, 1984) |
| "The inherited disease Lesch-Nyhan syndrome, which is caused by a deficiency of the enzyme hypoxanthine phosphoribosyltransferase (HPRT), is characterized by behavioural alterations, including self-injurious behaviour and mental retardation." | 3.68 | Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice. ( Melton, DW; Wu, CL, 1993) |
| "Rats ingesting high doses of caffeine reproduce the self-destructive behaviour observed in the Lesch-Nyhan syndrome." | 3.67 | Lesch-Nyhan syndrome, caffeine model: increase of purine and pyrimidine enzymes in rat brain. ( Grisolía, S; Jordá, A; Miñana, MD; Portolés, M, 1984) |
| "The free amino acid content in the cerebral cortex of rats administered caffeine orally, and with automutilation behavior similar to that observed in the Lesch-Nyhan syndrome, have been measured." | 3.67 | Caffeine-induced changes in the composition of the free amino acid pool of the cerebral cortex. ( Grisolía, S; Jordá, A; Miñana, MD; Portolés, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Devine, DP | 1 |
| Kasim, S | 1 |
| Jinnah, HA | 1 |
| Miñana, MD | 2 |
| Portolés, M | 2 |
| Jordá, A | 2 |
| Grisolía, S | 3 |
| Ferrer, I | 1 |
| Costell, M | 1 |
| Wu, CL | 1 |
| Melton, DW | 1 |
| Goth, R | 1 |
| Cleaver, JE | 1 |
7 other studies available for caffeine and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Animal models of self-injurious behaviour: an overview.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
Pharmacologic thresholds for self-injurious behavior in a genetic mouse model of Lesch-Nyhan disease.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Lesch-Nyhan syndrome, caffeine model: increase of purine and pyrimidine enzymes in rat brain.
Topics: Adenosine Deaminase; Animals; Aspartate Carbamoyltransferase; Brain; Caffeine; Dihydroorotase; Dihyd | 1984 |
Lesch-Nyhan syndrome-like behavior in rats from caffeine ingestion: changes in HGPRTase activity, urea and some nitrogen metabolism enzymes.
Topics: Acetylcholinesterase; Animals; Aspartate Carbamoyltransferase; Brain; Caffeine; Carbamoyl-Phosphate | 1982 |
Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice.
Topics: Adenine; Adenine Phosphoribosyltransferase; Animals; Brain; Caffeine; Cell Division; Cells, Cultured | 1993 |
Metabolism of caffeine to nucleic acid precursors in mammalian cells.
Topics: Animals; Caffeine; HeLa Cells; Humans; Lesch-Nyhan Syndrome; Mice; Nucleic Acid Precursors; Xeroderm | 1976 |
Caffeine-induced changes in the composition of the free amino acid pool of the cerebral cortex.
Topics: Amino Acids; Animals; Caffeine; Cerebral Cortex; Diet; Lesch-Nyhan Syndrome; Male; Rats; Rats, Inbre | 1985 |