caffeine and Innate Inflammatory Response studies

Research Excerpts

Excerpt	Relevance	Reference
"This study measured the influence of 2-weeks ingestion of high chlorogenic acid (CQA) coffee on postexercise inflammation and oxidative stress, with secondary outcomes including performance and mood state."	9.27	Influence of 2-Weeks Ingestion of High Chlorogenic Acid Coffee on Mood State, Performance, and Postexercise Inflammation and Oxidative Stress: A Randomized, Placebo-Controlled Trial. ( Arnot, R; Capps, CR; Goodman, CL; Nieman, DC; Shue, ZL, 2018)
"Preclinical studies have shown that the endogenous nucleoside adenosine prevents excessive tissue injury during systemic inflammation."	9.15	Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury. ( Franke, B; Peters, WH; Pickkers, P; Ramakers, BP; Riksen, NP; Smits, P; van den Broek, P; van der Hoeven, JG, 2011)
" Similarly, the consumption of caffeine antagonizes A2ARs, resulting in exacerbation of ongoing acute inflammation."	8.85	The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells. ( Belikoff, B; Hatfield, S; Lukashev, D; Ohta, A; Sitkovsky, M, 2009)
"This study aimed to investigate the association between prenatal caffeine ingestion (PCI) and risk of postnatal pulmonary inflammation."	7.85	Prenatal caffeine ingestion increases susceptibility to pulmonary inflammation in adult female rat offspring. ( Chen, T; Hou, LF; Liu, HX; Liu, S; Ping, J; Qu, W; Wen, X; Yan, HY, 2017)
"A single dose of caffeine at the initiation of sepsis did not alter survival."	7.81	Caffeine Improves Heart Rate Without Improving Sepsis Survival. ( Bauzá, G; Remick, D, 2015)
"Caffeine is presented in many commercial products and has been proven to induce ergogenic effects in exercise, mainly related to redox status homeostasis, inflammation and oxidative stress-related adaptation mechanisms."	7.80	Caffeine intake may modulate inflammation markers in trained rats. ( Amaral, GP; Barcelos, RP; Bresciani, G; de Vargas Barbosa, N; Fighera, MR; Soares, FA; Souza, MA; Stefanello, ST, 2014)
"In the present study, we report a synergistic interaction between acetylsalicylic acid (ASA) and caffeine (CAF) on the inhibition of nociception in a model of peripheral inflammation in rat; on the contrary no interaction have been found on anti-inflammatory effects and peripheral prostaglandin E2 (PGE-2) synthesis inhibition."	7.74	Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. ( Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2008)
"Pretreatment with caffeine to diabetic rats, resulted in improvement of structural changes and decrease in cytokine levels and immuno-markers, expression, and this was in a dose-dependent manner."	5.91	Caffeine protects against hippocampal alterations in type 2 diabetic rats via modulation of gliosis, inflammation and apoptosis. ( Al-Mahameed, AE; Fadel, R; Fatima, A; Jaradat, A; Nasr El-Din, WA; Othman, MA; Rashid, A; Tayem, Y, 2023)
"Glaucoma is the second leading cause of blindness worldwide, being characterized by progressive optic nerve damage and loss of retinal ganglion cells (RGCs), accompanied by increased inflammatory response involving retinal microglial cells."	5.43	Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma. ( Agudo-Barriuso, M; Ambrósio, AF; Madeira, MH; Nadal-Nícolas, F; Ortin-Martinez, A; Santiago, AR; Vidal-Sanz, M, 2016)
"d-galactose has been considered a senescent model for age-related neurodegenerative disease."	5.42	Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. ( Ali, T; Kim, MO; Ullah, F; Ullah, N, 2015)
"Treatment with theanine (1 mg/kg body mass, intraperitoneal injection) alone significantly reduced cerebral infarction induced by cerebral ischemia-reperfusion, but caffeine (10 mg/kg, intravenous administration) alone only had a marginal effect."	5.39	Beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral ischemia-reperfusion injury in rats. ( Feng, Y; Gou, L; Ling, X; Liu, Y; Sun, L; Tian, X; Wang, L; Yin, X, 2013)
"Caffeine ingestion was not significantly different between groups."	5.39	Oral caffeine during voluntary exercise markedly inhibits skin carcinogenesis and decreases inflammatory cytokines in UVB-treated mice. ( Bernard, JJ; Conney, AH; Li, T; Lin, Y; Lou, Y; Lu, Y; Nolan, B; Peng, Q; Shih, WJ; Wagner, GC, 2013)
"Caffeine has been shown to affect both metabolism and sleep."	5.37	Caffeine alters circadian rhythms and expression of disease and metabolic markers. ( Chapnik, N; Froy, O; Gutman, R; le Coutre, J; Meylan, J; Sherman, H, 2011)
"Chronic neuroinflammation is associated with an increase in extracellular levels of glutamate and drugs that limit the effects of glutamate at neuronal receptors have been shown to indirectly reduce the neuroinflammatory response of microglia cells."	5.36	Caffeine attenuates lipopolysaccharide-induced neuroinflammation. ( Brothers, HM; Marchalant, Y; Wenk, GL, 2010)
"Caffeine treatment augmented A1AR expression on microglia, with ensuing reduction of EAE severity, which was further enhanced by concomitant treatment with the A1AR agonist, adenosine amine congener."	5.32	A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis. ( Henry, S; Noorbakhsh, F; Power, C; Schnermann, J; Tsutsui, S; Warren, K; Winston, BW; Yong, VW, 2004)
"This study measured the influence of 2-weeks ingestion of high chlorogenic acid (CQA) coffee on postexercise inflammation and oxidative stress, with secondary outcomes including performance and mood state."	5.27	Influence of 2-Weeks Ingestion of High Chlorogenic Acid Coffee on Mood State, Performance, and Postexercise Inflammation and Oxidative Stress: A Randomized, Placebo-Controlled Trial. ( Arnot, R; Capps, CR; Goodman, CL; Nieman, DC; Shue, ZL, 2018)
"Preclinical studies have shown that the endogenous nucleoside adenosine prevents excessive tissue injury during systemic inflammation."	5.15	Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury. ( Franke, B; Peters, WH; Pickkers, P; Ramakers, BP; Riksen, NP; Smits, P; van den Broek, P; van der Hoeven, JG, 2011)
" Having the potential role in suppressing inflammation, immune modulation, antiviral and improving respiratory symptoms, this review discusses the potential role of methylxanthine drugs like pentoxifylline and caffeine in the management of COVID-19 patients."	5.05	Can pentoxifylline and similar xanthine derivatives find a niche in COVID-19 therapeutic strategies? A ray of hope in the midst of the pandemic. ( Al-Mahmood Siddiquee, A; Hashemian, F; Monji, F, 2020)
"Apnea of prematurity (AOP) is a common and pervasive problem in very low birth weight infants."	4.98	Caffeine: an evidence-based success story in VLBW pharmacotherapy. ( Dobson, NR; Hunt, CE, 2018)
" Similarly, the consumption of caffeine antagonizes A2ARs, resulting in exacerbation of ongoing acute inflammation."	4.85	The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells. ( Belikoff, B; Hatfield, S; Lukashev, D; Ohta, A; Sitkovsky, M, 2009)
" To seek RNAs involved in the anxiety disorder-metabolic disorder link, we subjected zebrafish larvae to caffeine-induced anxiety or high-fat diet (HFD)-induced obesity followed by RNA sequencing and analyses."	4.31	Inversely Regulated Inflammation-Related Processes Mediate Anxiety-Obesity Links in Zebrafish Larvae and Adults. ( Goldberg, D; Madrer, N; Meerson, A; Soreq, H; Yehuda, H, 2023)
"Our study suggested that HICH was accompanied by the increased inflammation marker levels in peripheral blood and brain, decreased gut microbiota diversity, altered gut metabolic phenotype and downregulation of caffeine metabolism pathway."	4.12	A pilot study: Gut microbiota, metabolism and inflammation in hypertensive intracerebral haemorrhage. ( Cheng, T; Huang, BS; Huang, JQ; Jiao, J; Li, D; Li, W; Li, ZS; Wu, LX; Xiong, Y; Yang, LJ, 2022)
"To investigate whether caffeine can be useful for control of inflammation derived from experimental systemic infection with Listeria monocytogenes."	4.02	Anti-inflammatory activity of caffeine (1,3,7-trimethylxanthine) after experimental challenge with virulent Listeria monocytogenes in Swiss mice. ( de Alcântara Almeida, I; Mancebo Dorvigny, B; Nunes Santana, L; Souza Tavares, L; Vitor Lima-Filho, J, 2021)
" A mouse model is presented that captures inflammation-associated cortical slow wave activity (SWA) observed in patients, allowing exploration of the mechanistic role of prostaglandin-adenosine signalling."	4.02	Electrophysiological signatures of acute systemic lipopolysaccharide-induced inflammation: potential implications for delirium science. ( Banks, MI; Grady, SM; Jaeckel, ER; Krause, BM; Murphy, CA; Sanders, RD; Sultan, ZW, 2021)
" Caffeine has anti-inflammation, antihepatic steatosis, and anti-insulin resistance effects."	3.88	Effects and mechanisms of caffeine to improve immunological and metabolic abnormalities in diet-induced obese rats. ( Hou, MC; Hsieh, YC; Huang, CC; Huang, SF; Lee, FY; Lee, KC; Lee, SD; Li, TH; Lin, HC; Lin, MW; Liu, CW; Su, YB; Tsai, CY; Tsai, HC; Yang, YY, 2018)
"This study aimed to investigate the association between prenatal caffeine ingestion (PCI) and risk of postnatal pulmonary inflammation."	3.85	Prenatal caffeine ingestion increases susceptibility to pulmonary inflammation in adult female rat offspring. ( Chen, T; Hou, LF; Liu, HX; Liu, S; Ping, J; Qu, W; Wen, X; Yan, HY, 2017)
"Serum caffeine concentrations >20 μg/ml (100 μmol/l) in infants treated for apnea of prematurity increases TNF-α and decreases IL-10, changes that perhaps are linked to comorbidities."	3.83	Mechanisms of modulation of cytokine release by human cord blood monocytes exposed to high concentrations of caffeine. ( Ahlawat, R; Chavez-Valdez, R; Gauda, EB; Wills-Karp, M, 2016)
"A single dose of caffeine at the initiation of sepsis did not alter survival."	3.81	Caffeine Improves Heart Rate Without Improving Sepsis Survival. ( Bauzá, G; Remick, D, 2015)
"Caffeine is presented in many commercial products and has been proven to induce ergogenic effects in exercise, mainly related to redox status homeostasis, inflammation and oxidative stress-related adaptation mechanisms."	3.80	Caffeine intake may modulate inflammation markers in trained rats. ( Amaral, GP; Barcelos, RP; Bresciani, G; de Vargas Barbosa, N; Fighera, MR; Soares, FA; Souza, MA; Stefanello, ST, 2014)
" This study characterized the manner in which levetiracetam interacts with analgesics (ibuprofen, celecoxib, and paracetamol) and caffeine to suppress hyperalgesia in a model of localized inflammation."	3.79	Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA, 2013)
"Both anandamide and adenosine have significant roles in pain mechanisms, but no data are available concerning their interaction at the spinal level."	3.75	The antinociceptive interaction of anandamide and adenosine at the spinal level. ( Benedek, G; Horvath, G; Kekesi, G; Nagy, E; Tuboly, G, 2009)
"In the present study, we report a synergistic interaction between acetylsalicylic acid (ASA) and caffeine (CAF) on the inhibition of nociception in a model of peripheral inflammation in rat; on the contrary no interaction have been found on anti-inflammatory effects and peripheral prostaglandin E2 (PGE-2) synthesis inhibition."	3.74	Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. ( Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2008)
"Caffeine has been found to potentiate the acute anti-inflammatory activity of aspirin, indomethacin, and phenylbutazone, but not the activity of sodium salicylate or hydrocortisone, in the carrageenan pleurisy or hindlimb models of inflammation in the rat."	3.65	Potentiation of the anti-inflammatory and analgesic activity of aspirin by caffeine in the rat. ( Ellis, CH; Selph, JL; Truax, JF; Vinegar, R; Welch, RM; White, HL, 1976)
"Obesity has become one of the major public health problems in both the developing and developed countries."	3.01	Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts. ( Che, H; Deng, Y; Huang, Y; Lao, J; Tang, Z; Wang, Y; Xu, C; Xu, H; Yin, H, 2023)
"Patients with advanced stage ovarian cancer and healthy volunteers were recruited."	2.90	Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation. ( Aboagye, EO; Clarke, S; Edwards, RJ; Lee, P; Liddle, C; Lozan-Kuehne, JP; Maslen, L; Ramaswami, R; Sharma, R; Trousil, S, 2019)
"The caffeine-induced increase in adrenaline could be responsible for the higher increase in IL-6 levels, as well as for the increased lactate levels."	2.78	Effects of caffeine on the inflammatory response induced by a 15-km run competition. ( Aguiló, A; Martínez, P; Martínez, S; Monjo, M; Moreno, C; Tauler, P, 2013)
"Caffeine intake has also shown ergogenic effects, which are attributed to different factors, such as enhanced substrate utilization, fatigue delay, and alertness."	2.66	Caffeine effects on systemic metabolism, oxidative-inflammatory pathways, and exercise performance. ( Barcelos, RP; Bresciani, G; Carvalho, NR; Lima, FD; Royes, LF, 2020)
"Pretreatment with caffeine to diabetic rats, resulted in improvement of structural changes and decrease in cytokine levels and immuno-markers, expression, and this was in a dose-dependent manner."	1.91	Caffeine protects against hippocampal alterations in type 2 diabetic rats via modulation of gliosis, inflammation and apoptosis. ( Al-Mahameed, AE; Fadel, R; Fatima, A; Jaradat, A; Nasr El-Din, WA; Othman, MA; Rashid, A; Tayem, Y, 2023)
"Low-grade chronic inflammation is associated with many chronic diseases and pathological conditions."	1.56	Effects of Habitual Caffeine Intake, Physical Activity Levels, and Sedentary Behavior on the Inflammatory Status in a Healthy Population. ( Aguilo, A; Martínez, S; Riera-Sampol, A; Rodas, L; Tauler, P, 2020)
"Caffeine, which is a competitive inhibitor of adenosine receptors, is commonly used as treatment for preterm apnoea in clinical settings."	1.56	Defining a Time Window for Neuroprotection and Glia Modulation by Caffeine After Neonatal Hypoxia-Ischaemia. ( Ådén, U; Blomgren, K; Bocchetta, E; Di Martino, E; Harris, RA; Mukai, T; Tsuji, S, 2020)
"Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics."	1.51	The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone. ( Azzolin, VF; Barbisan, F; da Cruz Jung, IE; da Cruz, IBM; da Cunha, BSN; do Prado-Lima, PA; Duarte, MMMF; Duarte, T; Ribeiro, EE; Turra, BO, 2019)
"Caffeine is a widely consumed pharmacologically active product."	1.48	Caffeine inhibits STAT1 signaling and downregulates inflammatory pathways involved in autoimmunity. ( Iris, M; Sawalha, AH; Tsou, PS, 2018)
"Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear."	1.46	Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. ( Blanco, P; Bolen, CR; Chang, J; Daburon, S; Davis, MM; Déchanet-Merville, J; Dekker, CL; Douchet, I; Faustin, B; Fragiadakis, GK; Furman, D; Ganio, EA; Gaudilliere, B; Haddad, F; Jojic, V; Kuo, CJ; Lartigue, L; Moreau, JF; Nolan, GP; Spitzer, MH, 2017)
"Transient retinal ischemia is a major complication of retinal degenerative diseases and contributes to visual impairment and blindness."	1.46	Treatment with A ( Aires, ID; Ambrósio, AF; Baqi, Y; Boia, R; Cunha, RA; Elvas, F; Madeira, MH; Müller, CE; Rodrigues-Neves, AC; Santiago, AR; Szabó, EC; Tomé, ÂR; Tralhão, P, 2017)
"Caffeine treatment also reduced the expression of pro-inflammatory genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-3, IL-6 and IL-12, and decreased both IL-6 secretion and phosphorylated p38MAPK expression in LPS-treated RAW264."	1.43	Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish. ( Hwang, JH; Kim, KJ; Lee, BY; Ryu, SJ, 2016)
"We have shown here that breast cancer cells and IL-6 persistently activate breast stromal fibroblasts through the stimulation of the positive IL-6/STAT3/NF-κB feedback loop."	1.43	The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts. ( Aboussekhra, A; Al-Ansari, MM; Al-Harbi, B; Hendrayani, SF; Silva, G, 2016)
"Glaucoma is the second leading cause of blindness worldwide, being characterized by progressive optic nerve damage and loss of retinal ganglion cells (RGCs), accompanied by increased inflammatory response involving retinal microglial cells."	1.43	Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma. ( Agudo-Barriuso, M; Ambrósio, AF; Madeira, MH; Nadal-Nícolas, F; Ortin-Martinez, A; Santiago, AR; Vidal-Sanz, M, 2016)
"d-galactose has been considered a senescent model for age-related neurodegenerative disease."	1.42	Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. ( Ali, T; Kim, MO; Ullah, F; Ullah, N, 2015)
"Caffeine has been reported to produce many beneficial effects for health."	1.40	Moderate swimming exercise and caffeine supplementation reduce the levels of inflammatory cytokines without causing oxidative stress in tissues of middle-aged rats. ( Bresciani, G; Carvalho, NR; Cechella, JL; da Rocha, JT; Dobrachinski, F; Duarte, MM; Leite, MR; Royes, LF; Soares, FA; Zeni, G, 2014)
"Caffeine ingestion was not significantly different between groups."	1.39	Oral caffeine during voluntary exercise markedly inhibits skin carcinogenesis and decreases inflammatory cytokines in UVB-treated mice. ( Bernard, JJ; Conney, AH; Li, T; Lin, Y; Lou, Y; Lu, Y; Nolan, B; Peng, Q; Shih, WJ; Wagner, GC, 2013)
"Treatment with theanine (1 mg/kg body mass, intraperitoneal injection) alone significantly reduced cerebral infarction induced by cerebral ischemia-reperfusion, but caffeine (10 mg/kg, intravenous administration) alone only had a marginal effect."	1.39	Beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral ischemia-reperfusion injury in rats. ( Feng, Y; Gou, L; Ling, X; Liu, Y; Sun, L; Tian, X; Wang, L; Yin, X, 2013)
" In this work, the antinociceptive and toxic effects of two new coordination complexes: Cu₂(fen)₄(caf)₂ [fen: fenoprofenate anion; caf: caffeine] and Cu₂(fen)₄(dmf)₂ [dmf: N-N'-dimethylformamide] were evaluated in mice."	1.38	Anti-nociceptive activity and toxicity evaluation of Cu(II)-fenoprofenate complexes in mice. ( Agotegaray, M; Bras, C; Gandini, NA; Gumilar, F; Minetti, A; Quinzani, O, 2012)
"Caffeine has been shown to affect both metabolism and sleep."	1.37	Caffeine alters circadian rhythms and expression of disease and metabolic markers. ( Chapnik, N; Froy, O; Gutman, R; le Coutre, J; Meylan, J; Sherman, H, 2011)
" The results suggest that the chronic intake of caffeine, as well as chronic low-intensity exercise, decreased muscle damage and inflammatory infiltration into skeletal muscle."	1.37	Effects of chronic caffeine intake and low-intensity exercise on skeletal muscle of Wistar rats. ( da Costa Santos, VB; de Paula Ramos, S; Juliani, LC; Nakamura, FY; Polito, MD; Ruiz, RJ; Siqueira, CP; Vettorato, ED, 2011)
"Treatment with caffeine significantly attenuated the elevated serum aminotransferase enzymes and reduced the severe extent of hepatic cell damage, steatosis and the immigration of inflammatory cells."	1.36	Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress. ( Chen, Z; Huang, C; Li, J; Liu, H; Lv, X; Zhang, L; Zhu, P, 2010)
"Chronic neuroinflammation is associated with an increase in extracellular levels of glutamate and drugs that limit the effects of glutamate at neuronal receptors have been shown to indirectly reduce the neuroinflammatory response of microglia cells."	1.36	Caffeine attenuates lipopolysaccharide-induced neuroinflammation. ( Brothers, HM; Marchalant, Y; Wenk, GL, 2010)
"In women with type 2 diabetes, higher caffeinated coffee consumption was associated with lower plasma concentrations of E-selectin (adjusted percentage change per 1 cup/d increment = -3."	1.33	Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. ( Hu, FB; Lopez-Garcia, E; Qi, L; van Dam, RM, 2006)
"Caffeine treatment augmented A1AR expression on microglia, with ensuing reduction of EAE severity, which was further enhanced by concomitant treatment with the A1AR agonist, adenosine amine congener."	1.32	A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis. ( Henry, S; Noorbakhsh, F; Power, C; Schnermann, J; Tsutsui, S; Warren, K; Winston, BW; Yong, VW, 2004)

Research

Studies (90)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Number of Participants Who Received the Influenza Vaccine

Adiponectin Total Area Under the Curve

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (12.22)	18.7374
1990's	2 (2.22)	18.2507
2000's	8 (8.89)	29.6817
2010's	53 (58.89)	24.3611
2020's	16 (17.78)	2.80

Authors	Studies
Saunders, MJ	1
Edwards, BS	1
Zhu, J	1
Sklar, LA	1
Graves, SW	1
Nozal, V	1
Martínez-González, L	1
Gomez-Almeria, M	1
Gonzalo-Consuegra, C	1
Santana, P	1
Chaikuad, A	1
Pérez-Cuevas, E	1
Knapp, S	1
Lietha, D	1
Ramírez, D	1
Petralla, S	1
Monti, B	1
Gil, C	1
Martín-Requero, A	1
Palomo, V	1
de Lago, E	1
Martinez, A	1
de Alcântara Almeida, I	1
Mancebo Dorvigny, B	1
Souza Tavares, L	1
Nunes Santana, L	1
Vitor Lima-Filho, J	1
Li, W	1
Wu, LX	1
Huang, BS	1
Yang, LJ	1
Huang, JQ	1
Li, ZS	1
Jiao, J	1
Cheng, T	1
Li, D	1
Xiong, Y	1
Ingegnoli, F	1
Cavalli, S	1
Giudice, L	1
Caporali, R	1
Raoofi, A	1
Delbari, A	1
Nasiry, D	1
Golmohammadi, R	1
Javadinia, SS	1
Sadrzadeh, R	1
Mojadadi, MS	1
Rustamzadeh, A	1
Mousavi Khaneghah, A	1
Ebrahimi, V	1
Rezaie, MJ	1
Othman, MA	1
Fadel, R	1
Tayem, Y	1
Jaradat, A	1
Rashid, A	1
Fatima, A	1
Al-Mahameed, AE	1
Nasr El-Din, WA	1
Yehuda, H	1
Madrer, N	1
Goldberg, D	1
Soreq, H	1
Meerson, A	1
Che, H	1
Wang, Y	2
Lao, J	1
Deng, Y	1
Xu, C	1
Yin, H	1
Tang, Z	1
Huang, Y	1
Xu, H	1
Alves, AO	1
Weis, GCC	1
Unfer, TC	1
Assmann, CE	1
Barbisan, F	2
Azzolin, VF	2
Chitolina, B	1
Duarte, T	2
Ribeiro-Filho, EE	1
Duarte, MMMF	2
Boligon, A	1
Vélez-Martin, E	1
Palma, TV	1
de Andrade, CM	2
da Cruz, IBM	3
Badshah, H	1
Ikram, M	1
Ali, W	1
Ahmad, S	1
Hahm, JR	1
Kim, MO	2
Di Martino, E	1
Bocchetta, E	1
Tsuji, S	1
Mukai, T	1
Harris, RA	1
Blomgren, K	1
Ådén, U	1
Barcelos, RP	2
Lima, FD	1
Carvalho, NR	2
Bresciani, G	3
Royes, LF	2
Rodas, L	1
Riera-Sampol, A	1
Aguilo, A	2
Martínez, S	2
Tauler, P	2
Monji, F	1
Al-Mahmood Siddiquee, A	1
Hashemian, F	1
Yılmaz, S	1
Göçmen, AY	1
Arıkan, ES	1
Akyüz, E	1
Tokpınar, A	1
Nisari, M	1
Unur, E	1
Yay, AH	1
Yalçın, B	1
Yılmaz, H	1
Ertekin, T	1
Güler, H	1
Sabitaliyevich, UY	1
Sultan, ZW	1
Jaeckel, ER	1
Krause, BM	1
Grady, SM	1
Murphy, CA	1
Sanders, RD	1
Banks, MI	1
Yamaguchi, M	1
Dohi, N	1
Ooka, A	1
Saito, SY	1
Ishikawa, T	1
Fujita, T	1
Feng, C	1
Takano, T	1
Macedo, RC	1
Bondan, EF	1
Otton, R	1
Paiva, C	1
Beserra, B	1
Reis, C	1
Dorea, JG	1
Da Costa, T	1
Amato, AA	1
Boia, R	2
Elvas, F	1
Madeira, MH	3
Aires, ID	1
Rodrigues-Neves, AC	1
Tralhão, P	1
Szabó, EC	1
Baqi, Y	1
Müller, CE	1
Tomé, ÂR	1
Cunha, RA	1
Ambrósio, AF	3
Santiago, AR	3
Nieman, DC	1
Goodman, CL	1
Capps, CR	1
Shue, ZL	1
Arnot, R	1
Liu, HX	1
Hou, LF	1
Chen, T	1
Qu, W	1
Liu, S	1
Yan, HY	1
Wen, X	1
Ping, J	1
Gao, X	1
Xie, Q	1
Kong, P	1
Liu, L	1
Sun, S	1
Xiong, B	1
Huang, B	1
Yan, L	1
Sheng, J	1
Xiang, H	1
Liu, CW	1
Tsai, HC	1
Huang, CC	1
Tsai, CY	1
Su, YB	1
Lin, MW	1
Lee, KC	1
Hsieh, YC	1
Li, TH	1
Huang, SF	1
Yang, YY	1
Hou, MC	1
Lin, HC	1
Lee, FY	1
Lee, SD	1
Aguirre-Martínez, GV	1
André, C	1
Gagné, F	1
Martín-Díaz, LM	1
Iris, M	1
Tsou, PS	1
Sawalha, AH	1
Dominguez, LJ	1
Barbagallo, M	1
Dobson, NR	1
Hunt, CE	1
Muhammad, M	1
El-Ta'alu, AB	1
Mohammed, MA	1
Yarube, IU	1
Nuhu, JM	1
Yusuf, I	1
Daneji, UA	1
Yoon, CS	1
Kim, MK	1
Kim, YS	1
Lee, SK	1
Nishitsuji, K	1
Watanabe, S	1
Xiao, J	1
Nagatomo, R	1
Ogawa, H	1
Tsunematsu, T	1
Umemoto, H	1
Morimoto, Y	1
Akatsu, H	1
Inoue, K	1
Tsuneyama, K	1
da Cunha, BSN	1
Turra, BO	1
da Cruz Jung, IE	1
Ribeiro, EE	1
do Prado-Lima, PA	1
Ruchel, JB	1
Bernardes, VM	1
Braun, JBS	1
Manzoni, AG	1
Passos, DF	1
Castilhos, LG	1
Abdalla, FH	1
de Oliveira, JS	1
Casali, EA	1
Leal, DBR	1
Trousil, S	1
Lee, P	1
Edwards, RJ	1
Maslen, L	1
Lozan-Kuehne, JP	1
Ramaswami, R	1
Aboagye, EO	1
Clarke, S	1
Liddle, C	1
Sharma, R	1
Sheth, S	1
Sheehan, K	1
Dhukhwa, A	1
Al Aameri, RFH	1
Mamillapalli, C	1
Mukherjea, D	1
Rybak, LP	1
Ramkumar, V	1
Scheff, NN	1
Lu, SG	1
Gold, MS	1
Katayama, M	1
Donai, K	1
Sakakibara, H	1
Ohtomo, Y	1
Miyagawa, M	1
Kuroda, K	1
Kodama, H	1
Suzuki, K	1
Kasai, N	1
Nishimori, K	1
Uchida, T	1
Watanabe, K	1
Aso, H	1
Isogai, E	1
Sone, H	1
Fukuda, T	1
Sun, L	1
Tian, X	1
Gou, L	1
Ling, X	1
Wang, L	1
Feng, Y	1
Yin, X	1
Liu, Y	1
Tomić, MA	1
Micov, AM	1
Stepanović-Petrović, RM	1
Lou, Y	1
Peng, Q	1
Li, T	1
Nolan, B	1
Bernard, JJ	1
Wagner, GC	1
Lin, Y	1
Shih, WJ	1
Conney, AH	1
Lu, Y	1
Cechella, JL	1
Leite, MR	1
Dobrachinski, F	1
da Rocha, JT	1
Duarte, MM	1
Soares, FA	2
Zeni, G	1
Souza, MA	1
Amaral, GP	1
Stefanello, ST	1
Fighera, MR	1
de Vargas Barbosa, N	1
Bauzá, G	1
Remick, D	1
Ullah, F	1
Ali, T	1
Ullah, N	1
Frau, L	1
Costa, G	1
Porceddu, PF	1
Khairnar, A	1
Castelli, MP	1
Ennas, MG	1
Madeddu, C	1
Wardas, J	2
Morelli, M	1
Hwang, JH	1
Kim, KJ	1
Ryu, SJ	1
Lee, BY	1
Chavez-Valdez, R	1
Ahlawat, R	1
Wills-Karp, M	1
Gauda, EB	1
Hendrayani, SF	1
Al-Harbi, B	1
Al-Ansari, MM	1
Silva, G	1
Aboussekhra, A	1
Ortin-Martinez, A	1
Nadal-Nícolas, F	1
Vidal-Sanz, M	1
Agudo-Barriuso, M	1
Muqaku, B	1
Tahir, A	1
Klepeisz, P	1
Bileck, A	1
Kreutz, D	1
Mayer, RL	1
Meier, SM	1
Gerner, M	1
Schmetterer, K	1
Gerner, C	1
Li, X	1
He, S	1
Li, R	1
Zhou, X	1
Zhang, S	1
Yu, M	1
Ye, Y	1
Huang, C	2
Wu, M	1
Furman, D	1
Chang, J	1
Lartigue, L	1
Bolen, CR	1
Haddad, F	1
Gaudilliere, B	1
Ganio, EA	1
Fragiadakis, GK	1
Spitzer, MH	1
Douchet, I	1
Daburon, S	1
Moreau, JF	1
Nolan, GP	1
Blanco, P	1
Déchanet-Merville, J	1
Dekker, CL	1
Jojic, V	1
Kuo, CJ	1
Davis, MM	1
Faustin, B	1
Endesfelder, S	1
Weichelt, U	1
Strauß, E	1
Schlör, A	1
Sifringer, M	1
Scheuer, T	1
Bührer, C	1
Schmitz, T	1
Swirski, FK	1
Nahrendorf, M	1
Tuboly, G	1
Kekesi, G	1
Nagy, E	1
Benedek, G	1
Horvath, G	1
Hatfield, S	1
Belikoff, B	1
Lukashev, D	1
Sitkovsky, M	1
Ohta, A	1
Kempf, K	1
Herder, C	1
Erlund, I	1
Kolb, H	1
Martin, S	1
Carstensen, M	1
Koenig, W	1
Sundvall, J	1
Bidel, S	1
Kuha, S	1
Tuomilehto, J	1
Lv, X	1
Chen, Z	1
Li, J	1
Zhang, L	1
Liu, H	1
Zhu, P	1
Brothers, HM	1
Marchalant, Y	1
Wenk, GL	1
Haskó, G	1
Cronstein, B	1
Ramakers, BP	1
Riksen, NP	1
van den Broek, P	1
Franke, B	1
Peters, WH	1
van der Hoeven, JG	1
Smits, P	1
Pickkers, P	1
Gavrieli, A	1
Yannakoulia, M	1
Fragopoulou, E	1
Margaritopoulos, D	1
Chamberland, JP	1
Kaisari, P	1
Kavouras, SA	1
Mantzoros, CS	1
Sherman, H	1
Gutman, R	1
Chapnik, N	1
Meylan, J	1
le Coutre, J	1
Froy, O	1
da Costa Santos, VB	1
Ruiz, RJ	1
Vettorato, ED	1
Nakamura, FY	1
Juliani, LC	1
Polito, MD	1
Siqueira, CP	1
de Paula Ramos, S	1
Gumilar, F	1
Agotegaray, M	1
Bras, C	1
Gandini, NA	1
Minetti, A	1
Quinzani, O	1
Yamaguchi, S	1
Suzuki, C	1
Noguchi, M	1
Kasa, S	1
Mori, M	1
Isozaki, Y	1
Ueda, S	1
Funahashi, H	1
Kikuchi, K	1
Nagai, T	1
Yoshioka, K	1
Gołembiowska, K	1
Noworyta-Sokołowska, K	1
Kamińska, K	1
Górska, A	1
Moreno, C	1
Monjo, M	1
Martínez, P	1
LENFELD, J	4
STOJAN, B	1
SLADKOVA, O	2
GRUNDMAN, M	2
BECK, C	1
Tsutsui, S	1
Schnermann, J	1
Noorbakhsh, F	1
Henry, S	1
Yong, VW	1
Winston, BW	1
Warren, K	1
Power, C	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Residual Immune Activation in HIV-infected Patients on Successful cART: Association Between Inflammasome Activation in Monocytes by Circulating Metabolites and Non AIDS Defining Comorbidities[NCT03191175]		55 participants (Actual)	Observational	2017-07-03	Completed
Immune Senescence in the Elderly: Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages[NCT01827462]	Phase 4	136 participants (Actual)	Interventional	2007-10-31	Completed
A Possible Therapeutic Role for Adenosine During Inflammation[NCT00513110]	Phase 1	33 participants (Anticipated)	Interventional	2007-08-31	Completed
The Effect of Different Amounts of Coffee on Dietary Intake, Appetite-related Feeling, Appetite Hormones, Glucose Metabolism and Inflammatory Markers of Normal Weight and Overweight/Obese Individuals[NCT01495754]		33 participants (Actual)	Interventional	2011-01-31	Completed
Acute Effects of Caffeinated and Decaffeinated Coffee Consumption on Energy Intake, Appetite, Inflammation and Glucose Metabolism[NCT01174576]		16 participants (Actual)	Interventional	2009-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	Participants (Count of Participants)
18-30 Years Old at Enrollment	59
60-79 Years Old at Enrollment	37
80-100 Years Old at Enrollment	40

Total area under the curve was defined as the sum of the areas under and over the baseline using the trapezoidal rule. The time points for the calculations were 15 min before beverage consumption, immediately after beverage consumption, 15, 30, 60, 90, 120, 150, 180 min postconsumption. (NCT01174576)
Timeframe: 15 min before ingestion to 3 h post ingestion

Cortisol Total Area Under the Curve

Intervention	ug*h/mL (Mean)
Caffeinated Coffee	22.7
Decaffeinated Coffee	22.6
Water	22.6

Energy ad Libitum Meal

Intervention	ug*h/dL (Mean)
Caffeinated Coffee	43.2
Decaffeinated Coffee	39.8
Water	35.0

The energy of first meal 3 hr after ingestion (NCT01174576)
Timeframe: 3 hr post ingestion

Ghrelin Total Area Under the Curve

Intervention	kcal (Mean)
Caffeinated Coffee	1749
Decaffeinated Coffee	1720
Water	1750

Glucagon-like Peptide-1 (GLP-1) Total Area Under the Curve

Intervention	ug*h/mL (Mean)
Caffeinated Coffee	2669
Decaffeinated Coffee	2593
Water	2672

Glucose Total Area Under the Curve

Intervention	ug*h/mL (Mean)
Caffeinated Coffee	43
Decaffeinated Coffee	45
Water	61

Insulin Total Area Under the Curve

Intervention	mg*h/dl (Mean)
Caffeinated Coffee	336
Decaffeinated Coffee	329
Water	323

Inteleukin-6 Total Area Under the Curve

Intervention	uU*h/ml (Mean)
Caffeinated Coffee	54
Decaffeinated Coffee	52
Water	52

Interleukin-18 Total Area Under the Curve

Intervention	pg*h/mL (Mean)
Caffeinated Coffee	5.4
Decaffeinated Coffee	5.5
Water	6.0

Peptide Tyrosine Tyrosine (PYY) Total Area Under the Curve

Intervention	pg*h/mL (Mean)
Caffeinated Coffee	818
Decaffeinated Coffee	777
Water	786

Serum Antioxidant Capacity Total Area Under the Curve

Intervention	pg*h/mL (Mean)
Caffeinated Coffee	251
Decaffeinated Coffee	286
Water	259

"Serum samples, collected 15 min before ingestion, immediately after ingestion, 15 min, 30 min, 60 min, 90 min, 120 min and 150 min after ingestion were analyzed for the ex vivo serum resistance to oxidative stress, that was induced by copper sulfate (CuSO4). The analysis of all collected samples was performed by the measurement of conjugated diene formation, which was monitored for every sample of all time points every 2 min for a 3.5 h period at 234 nm in a microplate spectrophotometer.~Total area under the curve was defined as the sum of the areas under and over the baseline using the trapezoidal rule. The time points for the calculations were 15 min before beverage consumption, immediately after beverage consumption, 15, 30, 60, 90, 120, 150 min postconsumption." (NCT01174576)
Timeframe: 15 min before ingestion to 21/2 hr post ingestion

Total Energy Intake

Intervention	lag time (min) *h (Mean)
Caffeinated Coffee	102
Decaffeinated Coffee	104
Water	108

the energy consumed at breakfast, ad libitum meal and rest of the experimental day (NCT01174576)
Timeframe: 1 d

Article	Year
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. Current protocols in cytometry, 2010, Volume: Chapter 13 Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr	2010
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; Case-Control Studies; DNA-Binding Proteins; Humans; I	2022
Anti-inflammatory activity of caffeine (1,3,7-trimethylxanthine) after experimental challenge with virulent Listeria monocytogenes in Swiss mice. International immunopharmacology, 2021, Volume: 100 Topics: Animals; Anti-Inflammatory Agents; Caffeine; Cells, Cultured; Chemotaxis, Leukocyte; Disease Models,	2021
A pilot study: Gut microbiota, metabolism and inflammation in hypertensive intracerebral haemorrhage. Journal of applied microbiology, 2022, Volume: 133, Issue:2 Topics: Caffeine; Chromatography, Liquid; Gastrointestinal Microbiome; Humans; Inflammation; Interleukin-10;	2022
Caffeine modulates apoptosis, oxidative stress, and inflammation damage induced by tramadol in cerebellum of male rats. Journal of chemical neuroanatomy, 2022, Volume: 123 Topics: Animals; Apoptosis; Caffeine; Caspase 3; Cerebellum; Inflammation; Male; Neuroprotective Agents; Oxi	2022
Caffeine protects against hippocampal alterations in type 2 diabetic rats via modulation of gliosis, inflammation and apoptosis. Cell and tissue research, 2023, Volume: 392, Issue:2 Topics: Animals; Apoptosis; Caffeine; Caspase 3; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellit	2023
Inversely Regulated Inflammation-Related Processes Mediate Anxiety-Obesity Links in Zebrafish Larvae and Adults. Cells, 2023, Jul-06, Volume: 12, Issue:13 Topics: Animals; Anxiety; Caffeine; Inflammation; Larva; Obesity; Zebrafish	2023
Caffeinated beverages contribute to a more efficient inflammatory response: Evidence from human and earthworm immune cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 134 Topics: Animals; Beverages; Caffeine; Cytokines; Humans; Inflammation; Inflammation Mediators; Leukocytes, M	2019
Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains. Biomolecules, 2019, 11-08, Volume: 9, Issue:11 Topics: Animals; Antioxidants; Apoptosis; Brain; Caffeine; Gene Expression Regulation; Heme Oxygenase-1; Hum	2019
Defining a Time Window for Neuroprotection and Glia Modulation by Caffeine After Neonatal Hypoxia-Ischaemia. Molecular neurobiology, 2020, Volume: 57, Issue:5 Topics: Animals; Brain Injuries; Caffeine; Demyelinating Diseases; DNA Fragmentation; Drug Administration Sc	2020
Effects of Habitual Caffeine Intake, Physical Activity Levels, and Sedentary Behavior on the Inflammatory Status in a Healthy Population. Nutrients, 2020, Aug-03, Volume: 12, Issue:8 Topics: Adiponectin; Adipose Tissue; Adolescent; Adult; Anti-Inflammatory Agents; Biomarkers; C-Reactive Pro	2020
The protective role of melatonin against the effects of different doses of caffeine on the fetus. Cellular and molecular biology (Noisy-le-Grand, France), 2020, Jul-31, Volume: 66, Issue:5 Topics: Animals; Antioxidants; Biomarkers; Bone and Bones; Caffeine; Female; Fetus; Inflammation; Liver; Mal	2020
Electrophysiological signatures of acute systemic lipopolysaccharide-induced inflammation: potential implications for delirium science. British journal of anaesthesia, 2021, Volume: 126, Issue:5 Topics: Adenosine; Age Factors; Animals; Caffeine; Cerebral Cortex; Cytokines; Delirium; Disease Models, Ani	2021
Caffeine-induced inversion of prostaglandin E Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 142 Topics: Animals; Caffeine; Cells, Cultured; Cyclic AMP; Dinoprostone; Gene Expression Regulation; Hepatic St	2021
Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia. Scientific reports, 2017, 06-13, Volume: 7, Issue:1 Topics: Acupuncture Analgesia; Animals; Caffeine; Central Nervous System Stimulants; Disease Models, Animal;	2017
Redox status on different regions of the central nervous system of obese and lean rats treated with green tea extract. Nutritional neuroscience, 2019, Volume: 22, Issue:2 Topics: Animals; Antioxidants; Caffeine; Catalase; Central Nervous System; Cytokines; Diet; Flavonoids; Gluc	2019
Treatment with A Cell death & disease, 2017, 10-05, Volume: 8, Issue:10 Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Humans; Inflammation; Ischemia; Mal	2017
Prenatal caffeine ingestion increases susceptibility to pulmonary inflammation in adult female rat offspring. Reproductive toxicology (Elmsford, N.Y.), 2017, Volume: 74 Topics: Animals; Caffeine; Cytokines; Female; Fetal Growth Retardation; Inflammation; Lung; Pregnancy; Prena	2017
Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice. Infection and immunity, 2018, Volume: 86, Issue:1 Topics: Animals; Caffeine; Cell Line; Cell Line, Tumor; Diet, High-Fat; Endotoxemia; Gastrointestinal Microb	2018
Effects and mechanisms of caffeine to improve immunological and metabolic abnormalities in diet-induced obese rats. American journal of physiology. Endocrinology and metabolism, 2018, 05-01, Volume: 314, Issue:5 Topics: Adiposity; Animals; Caffeine; Cells, Cultured; Diet, High-Fat; Fatty Liver; Immune System Diseases;	2018
The effects of human drugs in Corbicula fluminea. Assessment of neurotoxicity, inflammation, gametogenic activity, and energy status. Ecotoxicology and environmental safety, 2018, Volume: 148 Topics: Animals; Biomarkers; Caffeine; Carbamazepine; Corbicula; Energy Metabolism; Germ Cells; Humans; Ibup	2018
Caffeine inhibits STAT1 signaling and downregulates inflammatory pathways involved in autoimmunity. Clinical immunology (Orlando, Fla.), 2018, Volume: 192 Topics: Arthritis, Rheumatoid; Autoimmunity; Caffeine; Central Nervous System Stimulants; Cytokines; Down-Re	2018
Effect of Caffeine on Serum Tumour Necrosis Factor Alpha and Lactate Dehydrogenase in Wistar Rats Exposed to Cerebral Ischaemia-reperfusion Injury. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2018, Jun-30, Volume: 33, Issue:1 Topics: Animals; Caffeine; Disease Models, Animal; Inflammation; L-Lactate Dehydrogenase; Liver; Male; Rats,	2018
In vitro protein expression changes in RAW 264.7 cells and HUVECs treated with dialyzed coffee extract by immunoprecipitation high performance liquid chromatography. Scientific reports, 2018, 09-14, Volume: 8, Issue:1 Topics: Animals; Antioxidants; Apoptosis; Caffeine; Chlorogenic Acid; Chromatography, High Pressure Liquid;	2018
Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome. Scientific reports, 2018, 11-01, Volume: 8, Issue:1 Topics: Animals; Caffeine; Chlorogenic Acid; Coffee; Disease Models, Animal; Dysbiosis; Fatty Acids, Volatil	2018
The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone. Inflammation, 2019, Volume: 42, Issue:3 Topics: Animals; Antipsychotic Agents; Caffeine; Catechin; Cell Proliferation; Complex Mixtures; Inflammatio	2019
Lipotoxicity-associated inflammation is prevented by guarana ( Drug and chemical toxicology, 2021, Volume: 44, Issue:5 Topics: Adenosine; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Caffeine; Disease Models, Anim	2021
Oral Administration of Caffeine Exacerbates Cisplatin-Induced Hearing Loss. Scientific reports, 2019, 07-02, Volume: 9, Issue:1 Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Caffeine; Central Nervo	2019
Contribution of endoplasmic reticulum Ca2+ regulatory mechanisms to the inflammation-induced increase in the evoked Ca2+ transient in rat cutaneous dorsal root ganglion neurons. Cell calcium, 2013, Volume: 54, Issue:1 Topics: Animals; Caffeine; Calcium; Calcium Signaling; Cells, Cultured; Endoplasmic Reticulum; Freund's Adju	2013
Coffee consumption delays the hepatitis and suppresses the inflammation related gene expression in the Long-Evans Cinnamon rat. Clinical nutrition (Edinburgh, Scotland), 2014, Volume: 33, Issue:2 Topics: Adenosine Triphosphatases; Alanine Transaminase; Animals; Caffeine; Cation Transport Proteins; Cinna	2014
Beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral ischemia-reperfusion injury in rats. Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:7 Topics: Animals; Antioxidants; Brain Edema; Brain Ischemia; Caffeine; Cerebral Cortex; Cerebral Infarction;	2013
Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. The journal of pain, 2013, Volume: 14, Issue:11 Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Celecoxib; Dr	2013
Oral caffeine during voluntary exercise markedly inhibits skin carcinogenesis and decreases inflammatory cytokines in UVB-treated mice. Nutrition and cancer, 2013, Volume: 65, Issue:7 Topics: Adipose Tissue; Administration, Oral; Animals; Apoptosis; Caffeine; Carcinogenesis; Chemokines, CC;	2013
Moderate swimming exercise and caffeine supplementation reduce the levels of inflammatory cytokines without causing oxidative stress in tissues of middle-aged rats. Amino acids, 2014, Volume: 46, Issue:5 Topics: Aging; Animals; Caffeine; Cytokines; Dietary Supplements; Exercise Therapy; Humans; Inflammation; Li	2014
Caffeine intake may modulate inflammation markers in trained rats. Nutrients, 2014, Apr-21, Volume: 6, Issue:4 Topics: Acetylcholinesterase; Animals; Biomarkers; Caffeine; Inflammation; Male; Membrane Potentials; Mitoch	2014
Caffeine Improves Heart Rate Without Improving Sepsis Survival. Shock (Augusta, Ga.), 2015, Volume: 44, Issue:2 Topics: Animals; Caffeine; Central Nervous System Stimulants; Female; Heart Rate; Inflammation; Interleukin-	2015
Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. Neurochemistry international, 2015, Volume: 90 Topics: Aging; Animals; Antioxidants; Brain; Caffeine; Cognition Disorders; Disease Models, Animal; Galactos	2015
Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent. Journal of neurochemistry, 2016, Volume: 136, Issue:1 Topics: Age Factors; Aging; Animals; Caffeine; Dopaminergic Neurons; Drug Synergism; Inflammation; Male; Mic	2016
Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish. Chemico-biological interactions, 2016, Mar-25, Volume: 248 Topics: Animals; Caffeine; Cell Line; Cell Survival; Cytokines; Gene Expression Regulation; Inflammation; Li	2016
Mechanisms of modulation of cytokine release by human cord blood monocytes exposed to high concentrations of caffeine. Pediatric research, 2016, Volume: 80, Issue:1 Topics: Apgar Score; Apnea; Caffeine; Central Nervous System Stimulants; Comorbidity; Cyclic AMP; Cytokines;	2016
The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts. Oncotarget, 2016, Jul-05, Volume: 7, Issue:27 Topics: Breast; Breast Neoplasms; Caffeine; Cancer-Associated Fibroblasts; Cell Line; Cell Line, Tumor; Cell	2016
Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma. Scientific reports, 2016, 06-08, Volume: 6 Topics: Animals; Caffeine; Central Nervous System; Disease Models, Animal; Glaucoma; Humans; Inflammation; I	2016
Coffee consumption modulates inflammatory processes in an individual fashion. Molecular nutrition & food research, 2016, Volume: 60, Issue:12 Topics: Adult; Caffeine; Cells, Cultured; Chemokines; Coffee; Cytokines; Eicosanoids; Female; Humans; Inflam	2016
Pseudomonas aeruginosa infection augments inflammation through miR-301b repression of c-Myb-mediated immune activation and infiltration. Nature microbiology, 2016, 08-08, Volume: 1, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Caffeine; Cell Proliferation; Gene Expression Regulation; Host-Pa	2016
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature medicine, 2017, Volume: 23, Issue:2 Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;	2017
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature medicine, 2017, Volume: 23, Issue:2 Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;	2017
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature medicine, 2017, Volume: 23, Issue:2 Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;	2017
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature medicine, 2017, Volume: 23, Issue:2 Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;	2017
Neuroprotection by Caffeine in Hyperoxia-Induced Neonatal Brain Injury. International journal of molecular sciences, 2017, Jan-18, Volume: 18, Issue:1 Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Brain Injuries; Caffeine; Cytokines; Gene Expres	2017
Inflammation: Old, caffeinated, and healthy. Nature reviews. Cardiology, 2017, Volume: 14, Issue:4 Topics: Aged; Anti-Inflammatory Agents; Caffeine; Humans; Inflammasomes; Inflammation; Inflammation Mediator	2017
The antinociceptive interaction of anandamide and adenosine at the spinal level. Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:3 Topics: Adenosine; Analgesics; Animals; Arachidonic Acids; Caffeine; Dose-Response Relationship, Drug; Drug	2009
Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59, Issue:8 Topics: Animals; Caffeine; Cells, Cultured; Central Nervous System Stimulants; Chemokines; Cytochrome P-450	2010
Caffeine attenuates lipopolysaccharide-induced neuroinflammation. Neuroscience letters, 2010, Aug-16, Volume: 480, Issue:2 Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aging; Animals; Caffeine; Chro	2010
Caffeine alters circadian rhythms and expression of disease and metabolic markers. The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:5 Topics: Animals; Biomarkers; Body Weight; Caffeine; Caloric Restriction; Circadian Rhythm; Disease; Eating;	2011
Effects of chronic caffeine intake and low-intensity exercise on skeletal muscle of Wistar rats. Experimental physiology, 2011, Volume: 96, Issue:11 Topics: Adipose Tissue; Animals; Caffeine; Calcium; Creatine Kinase; Inflammation; Lactic Acid; Macrophages;	2011
Anti-nociceptive activity and toxicity evaluation of Cu(II)-fenoprofenate complexes in mice. European journal of pharmacology, 2012, Jan-30, Volume: 675, Issue:1-3 Topics: Abdominal Pain; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arousal; Caffeine; Cen	2012
Effects of adenosine receptor antagonists on the in vivo LPS-induced inflammation model of Parkinson's disease. Neurotoxicity research, 2013, Volume: 24, Issue:1 Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine	2013
[Analysis of the mechanism of action of caffeine in acute and subacute phases of formalin inflammation]. Ceskoslovenska fysiologie, 1959, Volume: 8, Issue:3 Topics: Caffeine; Formaldehyde; Inflammation	1959
[Contribution to the problem of neurohumoral regulation of inflammation]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1961, Volume: 241 Topics: Caffeine; Edema; Humans; Inflammation; Neurotransmitter Agents	1961
[ON THE MECHANISM OF INHIBITION OF INFLAMMATORY EDEMA WITH CAFFEINE, WITH REFERENCE TO SEROTONIN]. Casopis lekaru ceskych, 1963, May-17, Volume: 102 Topics: Caffeine; Chlorpromazine; Dextrans; Edema; Epinephrine; Formaldehyde; Inflammation; Rats; Research;	1963
[CHRONIC INFLAMMATIONS IN THE EPIPHARYNX]. Zeitschrift fur Laryngologie, Rhinologie, Otologie und ihre Grenzgebiete, 1964, Volume: 43 Topics: Caffeine; Drug Therapy; Humans; Inflammation; Pharyngitis; Procaine	1964
[On the mechanism of the inhibition of inflammatory swelling by caffeine with special reference to serotonin]. Ceskoslovenska fysiologie, 1960, Volume: 9 Topics: Caffeine; Humans; Inflammation; Serotonin	1960
A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Feb-11, Volume: 24, Issue:6 Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Caffeine; Disease Models, Animal; Disease Progre	2004
[Acute inflammation of the temporomandibular joint treated with impletol]. Zahnarztliche Welt, zahnarztliche Reform, ZWR, 1950, Jul-10, Volume: 5, Issue:13 Topics: Caffeine; Drug Combinations; Humans; Inflammation; Jaw; Procaine; Temporomandibular Joint	1950
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine? Journal of pharmacological sciences, 2006, Volume: 100, Issue:4 Topics: Analgesics; Animals; Caffeine; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response	2006
Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. The American journal of clinical nutrition, 2006, Volume: 84, Issue:4 Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Caffeine; Coffee; Cross-Sectional Studies; Diabetes Mel	2006
Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. European journal of pain (London, England), 2008, Volume: 12, Issue:2 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Carrageenan; Dinopr	2008
A device for automatic measurement of writhing and its application to the assessment of analgesic agents. Journal of pharmacological and toxicological methods, 1994, Volume: 32, Issue:2 Topics: Acetates; Acetic Acid; Aminopyrine; Analgesics; Animals; Behavior, Animal; Caffeine; Disease Models,	1994
Role of caffeine in combined analgesic drugs from the point of view of experimental pharmacology. Arzneimittel-Forschung, 1997, Volume: 47, Issue:8 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;	1997
Potentiation of the anti-inflammatory and analgesic activity of aspirin by caffeine in the rat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 151, Issue:3 Topics: Animals; Arthritis, Rheumatoid; Aspirin; Caffeine; Cyclooxygenase Inhibitors; Drug Therapy, Combinat	1976
Correlation of mucosal histology and aspirin intake in chronic gastric ulcer. Gastroenterology, 1973, Volume: 65, Issue:3 Topics: Adult; Aged; Aspirin; Caffeine; Chronic Disease; Epithelium; Female; Gastric Mucosa; Gastritis; Huma	1973
Effects of caffeine on the absorption and analgesic efficacy of paracetamol in rats. Pharmacology, 1973, Volume: 10, Issue:1 Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Caffeine; Depression, Chemical; Dose-Respo	1973
The toxicity of phenacetin at the range of the oral LD50(100 days) in albino rats. Toxicology and applied pharmacology, 1968, Volume: 12, Issue:1 Topics: Animals; Asthenia; Ataxia; Caffeine; Chemical and Drug Induced Liver Injury; Cyanosis; Dehydration;	1968
Polymorphonuclear leukocyte motility in vitro. I. Effect of pH, temperature, ethyl alcohol, and caffeine, using a modified Boyden chamber technic. Arthritis and rheumatism, 1969, Volume: 12, Issue:3 Topics: Anti-Inflammatory Agents; Bacterial Physiological Phenomena; Caffeine; Cell Movement; Chemotaxis; Et	1969

caffeine and Innate Inflammatory Response