caffeine and Inadequate Sleep studies

Research Excerpts

Excerpt	Relevance	Reference
"The current study investigated the effects of repeated caffeine administration on performance and subjective reports of sleepiness and fatigue during 50h extended wakefulness."	9.22	Caffeine administration at night during extended wakefulness effectively mitigates performance impairment but not subjective assessments of fatigue and sleepiness. ( Banks, S; Grant, C; Johnson, K; Kamimori, GH; Paech, GM; Pajcin, M; Vedova, CB, 2016)
" This research integrates physiologically based pharmacokinetic (PBPK) model predictions of caffeine concentrations in blood and tissues with ACT-R's fatigue module to predict the effects of caffeine on fatigue."	8.12	Physiocognitive Modeling: Explaining the Effects of Caffeine on Fatigue. ( Gearhart, JM; Gunzelmann, G; Halverson, T; Linakis, MW; Myers, CW, 2022)
"A recent physiologically based model of human sleep is extended to incorporate the effects of caffeine on sleep-wake timing and fatigue."	7.77	Incorporation of caffeine into a quantitative model of fatigue and sleep. ( Fulcher, BD; Phillips, AJ; Puckeridge, M; Robinson, PA, 2011)
"The extent to which modafinil and caffeine reverse fatigue effects (defined as performance decrements with time on task) during total sleep deprivation was investigated."	7.72	Modafinil vs. caffeine: effects on fatigue during sleep deprivation. ( Balkin, TJ; Belenky, G; Kautz, MA; Thorne, DR; Wesensten, NJ, 2004)
" Sleep deprivation alone has harmful consequences in relation to clinical outcomes and the physical and mental health of the surgeon, and to offset fatigue, some surgeons use legal stimulants such as caffeine and energy drinks."	5.41	Caffeine: benefits and drawbacks for technical performance. ( Brennan, PA; Harrap, I; Iqbal, S; Oeppen, RS; Parry, D, 2023)
"The current study investigated the effects of repeated caffeine administration on performance and subjective reports of sleepiness and fatigue during 50h extended wakefulness."	5.22	Caffeine administration at night during extended wakefulness effectively mitigates performance impairment but not subjective assessments of fatigue and sleepiness. ( Banks, S; Grant, C; Johnson, K; Kamimori, GH; Paech, GM; Pajcin, M; Vedova, CB, 2016)
" This report reviews the current literature on sleep patterns in adolescents, factors contributing to chronic sleep loss (ie, electronic media use, caffeine consumption), and health-related consequences, such as depression, increased obesity risk, and higher rates of drowsy driving accidents."	4.90	Insufficient sleep in adolescents and young adults: an update on causes and consequences. ( Owens, J, 2014)
"3% of children had at least 1 caregiver-reported sleep problem (66% insomnia symptoms, 64% electronics, 38% insufficient sleep, 21% caffeine, 17% snoring)."	4.31	Discrepancies Between Caregiver Reported Early Childhood Sleep Problems and Clinician Documentation and Referral. ( Bhandari, E; Carson, M; Cicalese, O; Fiks, AG; Mindell, JA; Stefanovski, D; Williamson, AA, 2023)
" This research integrates physiologically based pharmacokinetic (PBPK) model predictions of caffeine concentrations in blood and tissues with ACT-R's fatigue module to predict the effects of caffeine on fatigue."	4.12	Physiocognitive Modeling: Explaining the Effects of Caffeine on Fatigue. ( Gearhart, JM; Gunzelmann, G; Halverson, T; Linakis, MW; Myers, CW, 2022)
"10 years (mean ± standard error of the mean) wore actigraphs and completed diaries on subjective stress, fatigue, sleep quality, number of examinations and consumption of caffeine and alcohol for 4 weeks during their final year of secondary school."	3.79	Chronic stress undermines the compensatory sleep efficiency increase in response to sleep restriction in adolescents. ( Astill, RG; Van Someren, EJ; Verhoeven, D; Vijzelaar, RL, 2013)
"Recent evidence suggests that sleep deprivation leads to suboptimal decision-making on the Iowa Gambling Task (IGT), a pattern that appears to be unaffected by moderate doses of caffeine."	3.78	Gambling when sleep deprived: don't bet on stimulants. ( Balkin, TJ; Grugle, NL; Killgore, WD, 2012)
"A recent physiologically based model of human sleep is extended to incorporate the effects of caffeine on sleep-wake timing and fatigue."	3.77	Incorporation of caffeine into a quantitative model of fatigue and sleep. ( Fulcher, BD; Phillips, AJ; Puckeridge, M; Robinson, PA, 2011)
"The extent to which modafinil and caffeine reverse fatigue effects (defined as performance decrements with time on task) during total sleep deprivation was investigated."	3.72	Modafinil vs. caffeine: effects on fatigue during sleep deprivation. ( Balkin, TJ; Belenky, G; Kautz, MA; Thorne, DR; Wesensten, NJ, 2004)
"Compared with before sleep deprivation, the amplitudes of the event-related potentials (ERPs) increased in the N2 component and decreased in the P3 component after sleep deprivation in the placebo condition."	3.11	Modafinil ameliorates the decline in pronunciation-related working memory caused by 36-h acute total sleep deprivation: An ERP study. ( Dai, C; Lv, J; Peng, Z; Shao, Y; Song, T; Wang, L; Xu, L; Xu, M; Yang, X, 2022)
"Higher EEG theta activity related to sleep deprivation was observed in mutated TNF-α, PER3, and COMT carriers, in the placebo condition particularly."	3.01	Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882). ( Bourrilhon, C; Chennaoui, M; Drogou, C; Erblang, M; Erkel, MC; Gomez-Merino, D; Guillard, M; Léger, D; Quiquempoix, M; Rabat, A; Sauvet, F; Thomas, C; Trignol, A; Van Beers, P, 2021)
"One prominent proposal is that sleep deprivation impairs vigilant attention, and that impairments in vigilant attention cause impairments in cognitive tasks that require attention."	3.01	Caffeine selectively mitigates cognitive deficits caused by sleep deprivation. ( Altmann, EM; Fenn, KM; Stepan, ME, 2021)
"Remarkably, the combined effects of sleep fragmentation and coffee on glucose control upon waking per se have never been investigated."	2.94	Glucose control upon waking is unaffected by hourly sleep fragmentation during the night, but is impaired by morning caffeinated coffee. ( Betts, JA; Chen, YC; Gonzalez, JT; Heath, P; Hengist, A; Perkin, O; Smith, HA; Thomas, J; Walhin, JP, 2020)
"two days) of total sleep deprivation."	2.90	Effects of strategic early-morning caffeine gum administration on association between salivary alpha-amylase and neurobehavioural performance during 50 h of sleep deprivation. ( Aidman, E; Banks, S; Della Vedova, CB; Dorrian, J; Fidock, J; Grant, CL; Johnson, K; Kamimori, GH; Paech, GM; Pajcin, M; Tooley, K; White, JM, 2019)
"The neurobehavioral effects of repeated caffeine dosing during sleep deprivation were most evident during the circadian alertness trough (i."	2.90	Randomized, double-blind, placebo-controlled, crossover study of the effects of repeated-dose caffeine on neurobehavioral performance during 48 h of total sleep deprivation. ( Hansen, DA; Layton, ME; Ramakrishnan, S; Reifman, J; Satterfield, BC; Van Dongen, HPA; Wesensten, NJ, 2019)
"Both caffeine and sleep deprivation have been implicated in cardiovascular disease, but evidence is largely anecdotal."	2.90	Cardiac autonomic activity during sleep deprivation with and without caffeine administration. ( Crooks, E; Hansen, DA; Layton, ME; Satterfield, BC; Van Dongen, HPA, 2019)
"Insulin resistance was quantified with the homeostasis model."	2.82	Simultaneous coffee caffeine intake and sleep deprivation alter glucose homeostasis in Iranian men: a randomized crossover trial. ( Karandish, M; Karim, NA; Noor, MI; Rasaei, B; Talib, RA, 2016)
"Caffeine promotes wakefulness during night shift work, although it also disturbs subsequent daytime sleep."	2.79	Effects of caffeine on skin and core temperatures, alertness, and recovery sleep during circadian misalignment. ( McHill, AW; Smith, BJ; Wright, KP, 2014)
"These effects of sleep deprivation are counteracted by the adenosine receptor antagonist caffeine, implying involvement of the adenosine neuromodulator/receptor system."	2.77	Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation. ( Bachmann, V; Bodenmann, S; Deckert, J; Freitag, C; Hohoff, C; Landolt, HP; Rétey, JV, 2012)
"Previous research suggests that sleep deprivation is associated with declines in metabolic activity within brain regions important for judgement and impulse control, yet previous studies have reported inconsistent findings regarding the effects of sleep loss and caffeine on risk-taking."	2.76	Caffeine protects against increased risk-taking propensity during severe sleep deprivation. ( Balkin, TJ; Kamimori, GH; Killgore, WD, 2011)
"Negative effects of sleep deprivation on reaction time were reversed when caffeine (307 ms versus 299 ms in rested state; P = 0·214) or caffeine plus taurine (326 versus 299 ms; P = 0·110) was administered."	2.76	Effect of caffeine and taurine on simulated laparoscopy performed following sleep deprivation. ( Aggarwal, R; Crochet, P; Darzi, A; Mishra, A; Sirimanna, P, 2011)
"Relative to baseline, sleep deprivation was associated with lower scores on Total EQ (decreased global emotional intelligence), Intrapersonal functioning (reduced self-regard, assertiveness, sense of independence, and self-actualization), Interpersonal functioning (reduced empathy toward others and quality of interpersonal relationships), Stress Management skills (reduced impulse control and difficulty with delay of gratification), and Behavioral Coping (reduced positive thinking and action orientation)."	2.73	Sleep deprivation reduces perceived emotional intelligence and constructive thinking skills. ( Balkin, TJ; Kahn-Greene, ET; Kamimori, GH; Killgore, WD; Lipizzi, EL; Newman, RA, 2008)
"These findings suggest that sleep deprivation impairs the ability to integrate emotion and cognition to guide moral judgments, although susceptibility to the effects of sleep loss on this ability is moderated by the level of emotional intelligence."	2.73	The effects of 53 hours of sleep deprivation on moral judgment. ( Balkin, TJ; Day, LM; Kamimori, GH; Killgore, DB; Killgore, WD; Li, C, 2007)
"Caffeine also has effects on sleep."	2.73	Effects of caffeine are more marked on daytime recovery sleep than on nocturnal sleep. ( Carrier, J; Dumont, M; Fernandez-Bolanos, M; Filipini, D; Paquet, J; Robillard, R; Selmaoui, B, 2007)
"Data also reflected indirect effects of sleep deprivation that are consistent with an increase in homeostatic sleep drive."	2.73	Feasibility and behavioral effects of an at-home multi-night sleep restriction protocol for adolescents. ( Amin, R; Beebe, DW; Fallone, G; Flanigan, M; Godiwala, N; Martin, D; Schaffner, L, 2008)
"Caffeine has been suggested to act as a countermeasure against fatigue in military operations."	2.73	Effect of caffeine on simulator flight performance in sleep-deprived military pilot students. ( Huttunen, KH; Kilpeläinen, AA; Lahtinen, TM; Leino, TK; Lohi, JJ; Muhli, AA, 2007)
"Following 47 h of sleep deprivation, the study examined the effect of three stimulant medications (modafinil 400 mg, dextroamphetamine 20 mg, caffeine 600 mg) or placebo on the ability of 54 healthy participants to discriminate and label simple emotional expressions versus complex affect blends (created by morphing photographs of two different affective facial expressions)."	2.73	The effects of modafinil, caffeine, and dextroamphetamine on judgments of simple versus complex emotional expressions following sleep deprivation. ( Grugle, NL; Huck, NO; Kendall, AP; Killgore, WD; McBride, SA, 2008)
"Caffeine is a popular stimulant often used to counter the effects of sleep loss and fatigue."	2.73	Effects of acute caffeine withdrawal on Short Category Test performance in sleep-deprived individuals. ( Balkin, TJ; Kahn-Greene, ET; Kamimori, GH; Killgore, DB; Killgore, WD, 2007)
"During each sleep deprivation period subjects received either caffeine or placebo according to a randomized, double-blind cross-over design, and they completed an oral RNG task at 3-h intervals."	2.72	Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy. ( Achermann, P; Adam, M; Gottselig, JM; Khatami, R; Landolt, HP; Rétey, JV, 2006)
"In the placebo condition, sleep deprivation impaired PVT speed more in caffeine-sensitive than in caffeine-insensitive men."	2.72	Adenosinergic mechanisms contribute to individual differences in sleep deprivation-induced changes in neurobehavioral function and brain rhythmic activity. ( Achermann, P; Adam, M; Dürr, R; Gottselig, JM; Khatami, R; Landolt, HP; Rétey, JV, 2006)
"Ten subjects were evaluated after sleep deprivation, comparing the ingestion of either 400 mg of caffeine or placebo, in a double-blind randomized study."	2.72	Effects of caffeine on electrophysiological and neuropsychological indices after sleep deprivation. ( Cagy, M; Deslandes, A; Ferreira, C; Piedade, R; Pompeu, F; Ribeiro, P; Veiga, H, 2006)
"A long work schedule often results in sleep deprivation, sleepiness, impaired performance and fatigue."	2.71	Recovery after prolonged sleep deprivation: residual effects of slow-release caffeine on recovery sleep, sleepiness and cognitive functions. ( Batéjat, D; Beaumont, M; Chauffard, F; Coste, O; Doireau, P; Enslen, M; Lagarde, D; Pierard, C, 2005)
"Caffeine was administered to minimize deficits due to sleep deprivation."	2.71	Caffeine effects on marksmanship during high-stress military training with 72 hour sleep deprivation. ( Lieberman, HR; Shukitt-Hale, B; Tharion, WJ, 2003)
"At 10:00 (27 h sleep deprivation) subjects slept for 8 h, followed by Psychomotor Vigilance Task (PVT) administration at 33 and 65 min post-awakening."	2.71	Caffeine effects on recovery sleep following 27 h total sleep deprivation. ( Balkin, TJ; Belenky, G; Kamimori, GH; LaJambe, CM, 2005)
"When used to counteract the effects of sleep deprivation, multiple doses of caffeine are typically ingested across an extended period of time."	2.71	Multiple caffeine doses maintain vigilance during early morning operations. ( Belenky, G; Johnson, D; Kamimori, GH; Thorne, D, 2005)
"Performance decrements with sleep deprivation occurred in visual scanning, running memory, logical reasoning, mathematical processing, the Stroop test, the time wall test, tracking and visual vigilance."	2.71	Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation. ( Bray, GA; Lieberman, HR; Magill, RA; McNevin, N; Ryan, DH; Smith, SR; Volaufova, J; Waters, WF, 2003)
"The effect of partial sleep deprivation (PSD) on driving abilities, as measured with a driving simulator, and the value of slow-release caffeine as a countermeasure to the expected performance decrements, were studied."	2.70	Slow-release caffeine as a countermeasure to driver sleepiness induced by partial sleep deprivation. ( Cluydts, R; De Valck, E, 2001)
"Historical evidence suggests that sleep deprivation affects temporal memory, but this has not been studied systematically."	2.69	Sleep loss and temporal memory. ( Harrison, Y; Horne, JA, 2000)
" Based on single-dose caffeine studies, a similar dose-response effect has been hypothesized on performance, alertness and mood during sleep loss."	2.68	The use of caffeine versus prophylactic naps in sustained performance. ( Arand, DL; Bonnet, MH; Gomez, S; Wirth, O, 1995)
"Following 49 h of sleep deprivation, 37 healthy males ingested either 2."	2.68	Dose-dependent caffeine pharmacokinetics during severe sleep deprivation in humans. ( Brunhart, AE; Brunhart, GE; Chamberlain, AC; Eddington, ND; Kamimori, GH; Lugo, SI; Penetar, DM, 1995)
"Studies of stimulants during sleep deprivation have used performance assessment batteries (PABs) and occasionally the multiple sleep latency test (MSLT) as measures."	2.68	Sleep latency measures of caffeine effects during sleep deprivation. ( Bonnet, MH; Kelly, TL; Mitler, MM, 1997)
"Caffeine (200 mg) was administered at 20."	2.68	Combination of bright light and caffeine as a countermeasure for impaired alertness and performance during extended sleep deprivation. ( Badia, P; Myers, BL; Plenzler, SC; Wright, KP, 1997)
"Four treatments during a 45."	2.68	Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans. ( Badia, P; Hakel, M; Myers, BL; Plenzler, SC; Wright, KP, 1997)
"Caffeine reversed sleep deprivation-induced changes in three subscales of the POMS (vigor, fatigue, and confusion) and produced values close to fully rested conditions on several VAS."	2.67	Caffeine reversal of sleep deprivation effects on alertness and mood. ( Belenky, G; Galinski, C; Kamimori, G; McCann, U; Penetar, D; Sing, H; Thomas, M; Thorne, D, 1993)
"Moderators included sleep deprivation (n = 17), physical or mental exertion (n = 4), sleep deprivation combined with a sustained military operation (n = 3), and physical exertion combined with low ambient temperature (n = 1)."	2.55	Caffeine to optimize cognitive function for military mission-readiness: a systematic review and recommendations for the field. ( Arzola, SM; Berry, K; Bingham, JJ; Chittum, HK; Crawford, C; Drake, A; Gallon, MD; Lafferty, L; O'Connell, ML; Teo, L, 2017)
"The occurrence of chronic sleep deprivation in the population is commonplace."	2.43	Sleep deprivation. ( Kaplan, J; Malik, SW, 2005)
"Prolonged sleep deprivation is an exceptional situation, encountered in special environments such as sports, civilian and military, and which induces deficits in vigilance and performance."	2.39	Some measures to reduce effects of prolonged sleep deprivation. ( Batejat, D; Lagarde, D, 1995)
"To combat the adverse effects of sleep deprivation on physical and mental health, this article designed a new nasal temperature-sensitive gel loaded with caffeine, whose effects of awakening and improving cognition in sleep-deprived rats were evaluated."	1.72	Nasal Caffeine Thermo-Sensitive ( Du, L; Jin, Y; Li, L; Li, Q; Ma, J; Ma, S; Pang, L; Wang, C; Wang, X; Zhang, S; Zhang, Y; Zhu, S, 2022)
"Using the Unpredictable Chronic Sleep Deprivation (UCSD) paradigm we developed, the combined effects of chronic sleep deprivation and high caffeine intake on prefrontal cortical synaptophysin expression, neurochemical profiles, and behavioural outcomes in Long-Evans rats were evaluated."	1.72	Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. ( Adedokun, MA; Akinluyi, ET; Edem, EE; Fafure, AA; Ikuelogbon, DA; Nebo, KE; Okhonmina, UE; Olabiyi, AA, 2022)
"Performance after sleep deprivation and alcohol intake decreased, but not with a statistically significant difference (P = 0."	1.72	Effects of Sleep Deprivation, Non-Dominant Hand Employment, Caffeine and Alcohol Intake During Surgical Performance: Lessons Learned From the Retina Eyesi Virtual Reality Surgical Simulator. ( Adatia, FA; Chow, DR; González-Saldivar, G, 2022)
"Caffeine is a psychostimulant substance that is mostly used to prevent fatigue, increase alertness, and ameliorate sleep loss situations."	1.72	Chronic caffeine consumption improves the acute sleep deprivation-induced spatial memory impairment while altering N-methyl-D-aspartate receptor subunit expression in male rats. ( Cevik, OS; Keloglan, SM; Sahin, L, 2022)
"Caffeine is a common stimulant widely existed in food and has stimulatory effects on the central nervous system, shift-work individuals often rely on caffeine to maintain attention and keep awake."	1.62	Caffeine-related effects on cognitive performance: Roles of apoptosis in rat hippocampus following sleep deprivation. ( Huang, P; Huang, X; Li, H; Wang, P; Xie, G, 2021)
"In a placebo-controlled, 50-h total sleep deprivation (TSD) protocol we administered four 200 mg doses of caffeine-infused chewing-gum during night-time circadian trough and monitored participants' drowsiness during task performance with infra-red oculography."	1.62	Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study. ( Aidman, E; Balin, M; Banks, S; Fidock, J; Jackson, S; Johnson, K; Kamimori, GH; Mitchelson, E; Paech, GM; Pajcin, M; Vedova, CD; Yates, C, 2021)
"At rest, heart rate was similar in sleep deprivation and normal sleep conditions."	1.62	Sleep deprivation reduces vagal tone during an inspiratory endurance task in humans. ( Drouot, X; Fernagut, PO; Neau, JP; Ragot, S; Rault, C; Robert, R; Westphal, WP, 2021)
"Caffeine 2."	1.62	A MULTIFACTORIAL APPROACH FOR IMPROVING THE SURGICAL PERFORMANCE OF NOVICE VITREORETINAL SURGEONS. ( Belfort Junior, R; Dias Gomes Barrios Marin, V; Eid Farah, M; Gehlbach, PL; Jiramongkolchai, K; Maia, M; Muralha, F; Roizenblatt, M; Treiger Grupenmacher, A, 2021)
"Caffeine was administered daily in drinking water (0."	1.51	Caffeine as a potential arousal enhancer: altered NMDA subunit gene expression without improving cognitive performance in REM sleep deprived rats. ( Cevik, OS; Kocahan, S; Koyuncu, DD; Sahin, L, 2019)
"We found that sleep deprivation by feeding caffeine or by mechanical perturbation resulted in decreased egg output."	1.48	Sleep deprivation negatively impacts reproductive output in ( Daniel, DK; Lall, S; Potdar, S; Sheeba, V; Thomas, FA, 2018)
" We assessed the algorithm by comparing the caffeine-dosing strategies (timing and amount) it identified with the dosing strategies used in four experimental studies, involving total and partial sleep loss."	1.48	Caffeine dosing strategies to optimize alertness during sleep loss. ( Balkin, TJ; Doty, TJ; Ramakrishnan, S; Reifman, J; Vital-Lopez, FG, 2018)
"By comparing sleep deprivation to stress and caffeine to pharmacological cognitive enhancement, we illustrate that we cannot readily generalize from group results on one impairment or enhancement to another, even if they have similar effects on individual-level performance."	1.46	Sleep Deprivation Impairs and Caffeine Enhances My Performance, but Not Always Our Performance. ( Faber, NS; Häusser, JA; Kerr, NL, 2017)
"The consequences of chronic insufficient sleep for health remain uncertain."	1.46	Decreased alertness due to sleep loss increases pain sensitivity in mice. ( Alexandre, C; Ferreira, A; Latremoliere, A; Miracca, G; Scammell, TE; Woolf, CJ; Yamamoto, M, 2017)
"Caffeine treatment prevented the SD induced down-regulation of synaptophysin and synapsin I proteins with no change in PSD-95 protein in hippocampus."	1.42	Caffeine and modafinil given during 48 h sleep deprivation modulate object recognition memory and synaptic proteins in the hippocampus of the rat. ( Kauser, H; Kumari, P; Panjwani, U; Ray, K; Sahu, S; Wadhwa, M, 2015)
"The level of adenosine increases during sleep deprivation, and is thought to induce sleepiness and initiate sleep."	1.40	Caffeine increases light responsiveness of the mouse circadian pacemaker. ( Deboer, T; Groenen, I; Ijzerman, AP; Lucassen, EA; Meijer, JH; van Diepen, HC; Yasenkov, R, 2014)
"Caffeine treatment during SD, significantly increased early proliferative and post-mitotic stages of doublecortin (DCX) positive cells while modafinil treatment during SD, increased intermediate and post-mitotic stages of DCX positive cells compared to SD+Vehicle group."	1.39	Caffeine and modafinil promote adult neuronal cell proliferation during 48 h of total sleep deprivation in rat dentate gyrus. ( Kauser, H; Kishore, K; Kumar, S; Panjwani, U; Ray, K; Sahu, S, 2013)
"It is well known that caffeine and sleep deprivation have opposing effects on learning and memory; therefore, this study was undertaken to determine the effects of chronic (4wks) caffeine treatment (0."	1.37	Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: protection by caffeine. ( Aleisa, AM; Alhaider, IA; Alkadhi, KA; Tran, TT, 2011)
"We found that students get insufficient sleep and frequently use medication and alcohol as sleep aids, use stimulants as alertness aids, and fall asleep at the wheel, or have motor vehicle accidents due to sleepiness."	1.36	Patterns and consequences of inadequate sleep in college students: substance use and motor vehicle accidents. ( Bramoweth, AD; Taylor, DJ, 2010)
" The results suggest that chronic use of caffeine prevented anomalous changes in the basal levels of P-CaMKII and BDNF associated with sleep deprivation and as a result contributes to the revival of LTP in the DG region."	1.36	Caffeine prevents sleep loss-induced deficits in long-term potentiation and related signaling molecules in the dentate gyrus. ( Aleisa, AM; Alhaider, IA; Alkadhi, KA; Tran, TT, 2010)
" However, it is unknown to what extent such deficits are exacerbated in a dose-response manner by increasing levels of sleepiness, and the extent to which such sleep-loss-induced deficits can be reversed by caffeine."	1.34	Caffeine effects on risky decision making after 75 hours of sleep deprivation. ( Balkin, TJ; Kamimori, GH; Killgore, WD; Lipizzi, EL, 2007)
"Patients with insomnia had a higher sensitivity to the diurnal awakening effect of caffeine even after one night of SD."	1.33	Caffeine challenge in insomniac patients after total sleep deprivation. ( Campos, RM; Castaño, A; Salín-Pascual, RJ; Shiromani, PJ; Valencia-Flores, M, 2006)
"By 42 h postsleep deprivation, the amount of NREM recovered (70."	1.31	Caffeine during sleep deprivation: sleep tendency and dynamics of recovery sleep in rats. ( Edgar, DM; Wurts, SW, 2000)
"In Syrian hamsters, both sleep deprivation and adenosine A1 agonists can inhibit phase shifts of circadian rhythms to light at night."	1.31	Adenosine and caffeine modulate circadian rhythms in the Syrian hamster. ( Antle, MC; Mistlberger, RE; Steen, NM, 2001)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (1.57)	18.7374
1990's	15 (7.85)	18.2507
2000's	69 (36.13)	29.6817
2010's	74 (38.74)	24.3611
2020's	30 (15.71)	2.80

Authors	Studies
Roizenblatt, M	1
Jiramongkolchai, K	1
Gehlbach, PL	1
Dias Gomes Barrios Marin, V	1
Treiger Grupenmacher, A	1
Muralha, F	1
Eid Farah, M	1
Belfort Junior, R	1
Maia, M	1
Conde, SV	1
Martins, FO	1
Dias, SS	1
Pinto, P	1
Bárbara, C	1
Monteiro, EC	1
Xu, L	1
Yang, X	1
Peng, Z	1
Song, T	1
Wang, L	1
Dai, C	1
Xu, M	1
Shao, Y	1
Lv, J	1
Priezjev, NV	1
Vital-Lopez, FG	3
Reifman, J	7
Reichert, CF	1
Deboer, T	4
Landolt, HP	8
Zhu, S	1
Zhang, Y	1
Li, Q	1
Pang, L	1
Ma, J	1
Wang, C	1
Zhang, S	1
Jin, Y	1
Wang, X	1
Ma, S	1
Li, L	1
Du, L	1
Halverson, T	1
Myers, CW	1
Gearhart, JM	1
Linakis, MW	1
Gunzelmann, G	1
Khcharem, A	1
Souissi, W	1
Masmoudi, L	1
Sahnoun, Z	3
Keloglan, SM	1
Sahin, L	2
Cevik, OS	2
Adatia, FA	1
González-Saldivar, G	1
Chow, DR	1
Edem, EE	3
Okhonmina, UE	3
Nebo, KE	3
Akinluyi, ET	3
Ikuelogbon, DA	3
Fafure, AA	3
Olabiyi, AA	3
Adedokun, MA	3
Wingelaar-Jagt, YQ	2
Bottenheft, C	2
Riedel, WJ	2
Ramaekers, JG	2
Carson, M	1
Cicalese, O	1
Bhandari, E	1
Stefanovski, D	1
Fiks, AG	1
Mindell, JA	1
Williamson, AA	1
Gardiner, C	1
Weakley, J	1
Burke, LM	1
Roach, GD	1
Sargent, C	1
Maniar, N	1
Townshend, A	1
Halson, SL	1
Parry, D	1
Iqbal, S	1
Harrap, I	1
Oeppen, RS	1
Brennan, PA	1
Quiquempoix, M	2
Drogou, C	2
Erblang, M	2
Van Beers, P	3
Guillard, M	2
Tardo-Dino, PE	1
Rabat, A	2
Léger, D	2
Chennaoui, M	2
Gomez-Merino, D	2
Sauvet, F	2
Doty, TJ	3
Anlap, I	1
Killgore, WDS	1
Chabal, S	1
Folstein, JR	1
Chinoy, ED	1
Markwald, RR	1
Lieberman, HR	5
Crooks, E	1
Hansen, DA	2
Satterfield, BC	2
Layton, ME	2
Van Dongen, HPA	2
Reichert, S	1
Pavón Arocas, O	1
Rihel, J	1
Irwin, C	1
Khalesi, S	1
Desbrow, B	1
McCartney, D	1
Wallace, PJ	1
Haber, JJ	1
Smith, HA	1
Hengist, A	1
Thomas, J	1
Walhin, JP	1
Heath, P	1
Perkin, O	1
Chen, YC	1
Gonzalez, JT	1
Betts, JA	1
Sholtes, D	1
Kravitz, HM	1
Deka, A	1
Westrick, J	1
Fogg, LF	1
Gottlieb, M	1
Xie, G	1
Huang, X	1
Li, H	1
Wang, P	1
Huang, P	1
Baur, DM	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Effects of Sleep Deprivation on Diaphragm Command During an Inspiratory Endurance Trial in Healthy Volunteers.[NCT02725190]		20 participants (Actual)	Interventional	2016-04-30	Completed
Polymorphisms and Efficiency of Caffeine on Performances During Total Sleep Deprivation un Healthy Subject. Multicentric, Versus Placebo, Randomised, Cross Over, Double Blind Study[NCT03859882]		52 participants (Actual)	Interventional	2018-09-02	Completed
A Head-to-Head Comparison of the 2B-Alert Caffeine Optimization Algorithm Versus Standard Caffeine Dosing on Performance During Sleep Deprivation (2B-2)[NCT05588934]		180 participants (Anticipated)	Interventional	2023-02-28	Not yet recruiting
The Effect of Sleep Extension in Teenage Girls at a College Preparatory High School[NCT04285307]		35 participants (Anticipated)	Interventional	2018-04-13	Active, not recruiting
Performance Nutrition for Residents and Fellows Working Overnight Shifts: A Pilot Study[NCT03698123]		61 participants (Actual)	Interventional	2018-10-29	Completed
Countermeasures for Sleepiness at the Wheel and Prediction of Inter- Individual Differences to Their Responses (KillSleep)[NCT01070004]		72 participants (Actual)	Interventional	2010-01-31	Completed
Ranger Resilience and Improved Performance on Phospholipid Bound Omega-3's[NCT02908932]		555 participants (Actual)	Interventional	2016-08-31	Completed
Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery: a Randomized, Placebo Controlled Trial[NCT02734238]	Phase 4	53 participants (Actual)	Interventional	2016-04-30	Completed
The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial[NCT02832336]	Phase 1/Phase 2	16 participants (Actual)	Interventional	2016-10-01	Completed
The Impact of Caffeine on Cognition in Schizophrenia[NCT02832401]		24 participants (Actual)	Interventional	2016-09-02	Completed
The Effects of a Combination of Napping and Bright Light Pulses on Shift Workers Sleepiness at the Wheel A Pilot Study[NCT00487292]		9 participants (Actual)	Interventional	2003-04-30	Completed
Method of Assessment of Driving Ability in Patients Suffering From Wakefulness Pathologies, Impact of Modafinil Treatment.[NCT00916253]		27 participants (Actual)	Interventional	2010-03-31	Completed
Circadian Integration of Photic and Non-photic Stimuli[NCT00387179]		48 participants (Anticipated)	Interventional	2006-10-31	Recruiting
Operational Evaluation of a Photic Countermeasure to Improve Alertness, Performance, and Mood During Nightshift Work on a 105-day Simulated Human Exploration Mission to Mars[NCT01169233]		25 participants (Actual)	Interventional	2008-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Height was measured using a stadiometer. Weight was measured using a calibrated digital scale. Body composition was determined using dual-energy X-ray absorptiometry. These data were used to calculate fat-free body mass, fat mass, and total body tissue mass. (NCT02734238)
Timeframe: end of each study phase: Day 11 for Phase 1, Day 39 for Phase 2, up to Day 85 for Phase 3

Intervention	kilograms (Least Squares Mean)
	Total Body Mass at end of Phase 1	Total Body Mass at end of Phase 2	Total Body Mass at end of Phase 3	Fat-free Mass at end of Phase 1	Fat-free Mass at end of Phase 2	Fat-free Mass at end of Phase 3	Fat Mass at end of Phase 1	Fat Mass at end of Phase 2	Fat Mass at end of Phase 3
Energy Deficit	78.3	73.3	76.5	58.3	58.0	60.5	16.8	12.2	12.8
Energy Deficit + Testosterone	78.0	75.8	79.3	57.9	60.4	63.1	16.8	12.0	12.8

Article	Year
Adenosine, caffeine, and sleep-wake regulation: state of the science and perspectives. Journal of sleep research, 2022, Volume: 31, Issue:4 Topics: Adenosine; Caffeine; Circadian Rhythm; Humans; Sleep; Sleep Deprivation; Wakefulness	2022
The effect of caffeine on subsequent sleep: A systematic review and meta-analysis. Sleep medicine reviews, 2023, Volume: 69 Topics: Caffeine; Coffee; Humans; Polysomnography; Sleep; Sleep Deprivation	2023
Caffeine: benefits and drawbacks for technical performance. The British journal of oral & maxillofacial surgery, 2023, Volume: 61, Issue:3 Topics: Caffeine; Central Nervous System Stimulants; Fatigue; Humans; Sleep; Sleep Deprivation	2023
Effects of acute caffeine consumption following sleep loss on cognitive, physical, occupational and driving performance: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews, 2020, Volume: 108 Topics: Attention; Automobile Driving; Caffeine; Central Nervous System Stimulants; Executive Function; Huma	2020
Optimising sleep and performance during night float: A systematic review of evidence and implications for graduate medical education trainees. Journal of sleep research, 2021, Volume: 30, Issue:4 Topics: Adaptation, Physiological; Attention; Caffeine; Education, Medical, Graduate; Energy Drinks; Fatigue	2021
The effects of caffeinated products on sleep and functioning in the military population: A focused review. Pharmacology, biochemistry, and behavior, 2021, Volume: 206 Topics: Caffeine; Clinical Trials as Topic; Coffee; Cognition; Energy Drinks; Female; Humans; Male; Military	2021
Caffeine to optimize cognitive function for military mission-readiness: a systematic review and recommendations for the field. Nutrition reviews, 2017, 06-01, Volume: 75, Issue:suppl_2 Topics: Attention; Caffeine; Cognition; Diet; Evidence-Based Practice; Humans; Military Medicine; Military P	2017
Fatigue on the flight deck: the consequences of sleep loss and the benefits of napping. Accident; analysis and prevention, 2014, Volume: 62 Topics: Aerospace Medicine; Caffeine; Central Nervous System Stimulants; Fatigue; Humans; Safety; Sleep; Sle	2014
Adenosine, caffeine, and performance: from cognitive neuroscience of sleep to sleep pharmacogenetics. Current topics in behavioral neurosciences, 2015, Volume: 25 Topics: Adenosine; Attention; Caffeine; Humans; Neurosciences; Pharmacogenetics; Psychomotor Performance; Sl	2015
Insufficient sleep in adolescents and young adults: an update on causes and consequences. Pediatrics, 2014, Volume: 134, Issue:3 Topics: Accidents, Traffic; Adolescent; Caffeine; Communications Media; Depression; Humans; Obesity; Sleep;	2014
Cumulative neurobehavioral and physiological effects of chronic caffeine intake: individual differences and implications for the use of caffeinated energy products. Nutrition reviews, 2014, Volume: 72 Suppl 1 Topics: Attention; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Energy Drinks; Fatigue; Hu	2014
Sleep: a good investment in health and safety. Journal of agromedicine, 2008, Volume: 13, Issue:2 Topics: Age Factors; Aged; Aging; Agriculture; Caffeine; Central Nervous System Stimulants; Fatigue; Female;	2008
Losing sleep over the caffeination of prematurity. The Journal of physiology, 2009, Nov-15, Volume: 587, Issue:Pt 22 Topics: Animals; Caffeine; Humans; Infant, Newborn; Infant, Premature; Sleep; Sleep Apnea Syndromes; Sleep D	2009
Effects of caffeine on sleep and cognition. Progress in brain research, 2011, Volume: 190 Topics: Caffeine; Central Nervous System Stimulants; Cognition; Executive Function; Humans; Psychomotor Perf	2011
Caffeine withdrawal, sleepiness, and driving performance: what does the research really tell us? Nutritional neuroscience, 2011, Volume: 14, Issue:3 Topics: Attention; Automobile Driving; Caffeine; Central Nervous System Stimulants; Humans; Narcolepsy; Reac	2011
Changes in gene expression with sleep. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2011, Oct-15, Volume: 7, Issue:5 Suppl Topics: Animals; Biomarkers; Caffeine; Central Nervous System Stimulants; Drosophila melanogaster; Gene Expr	2011
Shift work and the assessment and management of shift work disorder (SWD). Sleep medicine reviews, 2013, Volume: 17, Issue:1 Topics: Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Disorders of Excessive Somnolence; He	2013
Familial paroxysmal nonkinesigenic dyskinesia: clinical and genetic analysis of a Taiwanese family. Journal of the neurological sciences, 2012, Dec-15, Volume: 323, Issue:1-2 Topics: Adult; Age of Onset; Amino Acid Sequence; Base Sequence; Caffeine; Child, Preschool; Chorea; Clonaze	2012
Modafinil--medical considerations for use in sustained operations. Aviation, space, and environmental medicine, 2003, Volume: 74, Issue:6 Pt 1 Topics: Caffeine; Central Nervous System Stimulants; Dextroamphetamine; Humans; Sleep; Sleep Deprivation	2003
Sleep deprivation. Primary care, 2005, Volume: 32, Issue:2 Topics: Benzhydryl Compounds; Caffeine; Disorders of Excessive Somnolence; Humans; Modafinil; Primary Health	2005
Effects of caffeine on performance and mood: withdrawal reversal is the most plausible explanation. Psychopharmacology, 2005, Volume: 182, Issue:1 Topics: Affect; Arousal; Attention; Caffeine; Central Nervous System Stimulants; Drug Tolerance; Follow-Up S	2005
The use of stimulants to modify performance during sleep loss: a review by the sleep deprivation and Stimulant Task Force of the American Academy of Sleep Medicine. Sleep, 2005, Volume: 28, Issue:9 Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Humans; Methamphetamine; Modafini	2005
Caffeine: sleep and daytime sleepiness. Sleep medicine reviews, 2008, Volume: 12, Issue:2 Topics: Adult; Caffeine; Central Nervous System Stimulants; Disorders of Excessive Somnolence; Humans; Sleep	2008
Some measures to reduce effects of prolonged sleep deprivation. Neurophysiologie clinique = Clinical neurophysiology, 1995, Volume: 25, Issue:6 Topics: Amphetamines; Caffeine; Central Nervous System Stimulants; Humans; Hypnotics and Sedatives; Sleep De	1995
[Headache and chronic sleep deprivation: an often missed relationship in children and also in adults]. Nederlands tijdschrift voor geneeskunde, 1999, Sep-18, Volume: 143, Issue:38 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Caffeine; Central Nervous System Stimulants; Child; Ch	1999
Exogenous factors in panic disorder: clinical and research implications. The Journal of clinical psychiatry, 1988, Volume: 49, Issue:2 Topics: Anxiety Disorders; Caffeine; Cocaine; Diet; Ethanol; Fear; Humans; Life Change Events; Marijuana Abu	1988

Article	Year
Modafinil ameliorates the decline in pronunciation-related working memory caused by 36-h acute total sleep deprivation: An ERP study. Neurobiology of learning and memory, 2022, Volume: 192 Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Humans; Male; Memory, Short-Term;	2022
Repeated low-dose caffeine ingestion during a night of total sleep deprivation improves endurance performance and cognitive function in young recreational runners: A randomized, double-blind, placebo-controlled study. Chronobiology international, 2022, Volume: 39, Issue:9 Topics: Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Cognition; Cross-Over Studies; Double	2022
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial. Journal of psychopharmacology (Oxford, England), 2023, Volume: 37, Issue:2 Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum	2023
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial. Journal of psychopharmacology (Oxford, England), 2023, Volume: 37, Issue:2 Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum	2023
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial. Journal of psychopharmacology (Oxford, England), 2023, Volume: 37, Issue:2 Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum	2023
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial. Journal of psychopharmacology (Oxford, England), 2023, Volume: 37, Issue:2 Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum	2023
Relationship between Habitual Caffeine Consumption, Attentional Performance, and Individual Alpha Frequency during Total Sleep Deprivation. International journal of environmental research and public health, 2023, 03-11, Volume: 20, Issue:6 Topics: Attention; Caffeine; Humans; Psychomotor Performance; Reaction Time; Sleep; Sleep Deprivation; Wakef	2023
Cardiac autonomic activity during sleep deprivation with and without caffeine administration. Physiology & behavior, 2019, 10-15, Volume: 210 Topics: Adult; Autonomic Nervous System; Caffeine; Central Nervous System Stimulants; Dose-Response Relation	2019
Glucose control upon waking is unaffected by hourly sleep fragmentation during the night, but is impaired by morning caffeinated coffee. The British journal of nutrition, 2020, 11-28, Volume: 124, Issue:10 Topics: Blood Glucose; Caffeine; Coffee; Cross-Over Studies; Female; Genotype; Glucose Tolerance Test; Glyce	2020
Caffeine Use or Napping to Enhance Repeated Sprint Performance After Partial Sleep Deprivation: Why Not Both? International journal of sports physiology and performance, 2021, 05-01, Volume: 16, Issue:5 Topics: Athletes; Athletic Performance; Caffeine; Double-Blind Method; Humans; Male; Sleep; Sleep Deprivatio	2021
Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882). Genes, 2021, 04-10, Volume: 12, Issue:4 Topics: Adult; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double-Blind Method; Female;	2021
Caffeine selectively mitigates cognitive deficits caused by sleep deprivation. Journal of experimental psychology. Learning, memory, and cognition, 2021, Volume: 47, Issue:9 Topics: Caffeine; Cognition; Humans; Psychomotor Performance; Sleep; Sleep Deprivation; Wakefulness	2021
Effects of strategic early-morning caffeine gum administration on association between salivary alpha-amylase and neurobehavioural performance during 50 h of sleep deprivation. Accident; analysis and prevention, 2019, Volume: 126 Topics: Adult; Attention; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Female; Humans;	2019
Using coffee to compensate for poor sleep: Impact on vigilance and implications for workplace performance. Applied ergonomics, 2018, Volume: 70 Topics: Adolescent; Arousal; Caffeine; Central Nervous System Stimulants; Coffee; Cognition; Efficiency; Hum	2018
Randomized, double-blind, placebo-controlled, crossover study of the effects of repeated-dose caffeine on neurobehavioral performance during 48 h of total sleep deprivation. Psychopharmacology, 2019, Volume: 236, Issue:4 Topics: Adult; Attention; Caffeine; Chewing Gum; Cross-Over Studies; Dose-Response Relationship, Drug; Doubl	2019
An evaluation of the cognitive and mood effects of an energy shot over a 6h period in volunteers: a randomized, double-blind, placebo controlled, cross-over study. Appetite, 2013, Volume: 67 Topics: Adult; Affect; Analysis of Variance; Attention; Blood Glucose; Caffeine; Cognition; Cross-Over Studi	2013
Combined caffeine and bright light reduces dangerous driving in sleep-deprived healthy volunteers: a pilot cross-over randomised controlled trial. Neurophysiologie clinique = Clinical neurophysiology, 2013, Volume: 43, Issue:3 Topics: Adult; Arousal; Caffeine; Central Nervous System Stimulants; Computer Simulation; Cross-Over Studies	2013
Sleep restriction and serving accuracy in performance tennis players, and effects of caffeine. Physiology & behavior, 2013, Aug-15, Volume: 120 Topics: Adolescent; Athletic Performance; Caffeine; Central Nervous System Stimulants; Double-Blind Method;	2013
Building a self-regulatory model of sleep deprivation and deception: the role of caffeine and social influence. The Journal of applied psychology, 2014, Volume: 99, Issue:6 Topics: Adult; Caffeine; Deception; Female; Humans; Male; Models, Psychological; Organizational Culture; Sle	2014
Effects of caffeine on skin and core temperatures, alertness, and recovery sleep during circadian misalignment. Journal of biological rhythms, 2014, Volume: 29, Issue:2 Topics: Adolescent; Adult; Affect; Analysis of Variance; Attention; Body Temperature; Caffeine; Central Nerv	2014
Caffeine improves the efficiency of planning and sequencing abilities during sleep deprivation. Journal of clinical psychopharmacology, 2014, Volume: 34, Issue:5 Topics: Adult; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Executive Function; Female;	2014
Caffeine administration at night during extended wakefulness effectively mitigates performance impairment but not subjective assessments of fatigue and sleepiness. Pharmacology, biochemistry, and behavior, 2016, Volume: 145 Topics: Caffeine; Cognition Disorders; Double-Blind Method; Drug Administration Schedule; Fatigue; Female; H	2016
Simultaneous coffee caffeine intake and sleep deprivation alter glucose homeostasis in Iranian men: a randomized crossover trial. Asia Pacific journal of clinical nutrition, 2016, Volume: 25, Issue:4 Topics: Adult; Blood Glucose; Caffeine; Coffee; Cross-Over Studies; Fasting; Glucose Tolerance Test; Homeost	2016
Stair walking is more energizing than low dose caffeine in sleep deprived young women. Physiology & behavior, 2017, 05-15, Volume: 174 Topics: Adolescent; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Dose-Response Relations	2017
Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness. Journal of sleep research, 2008, Volume: 17, Issue:3 Topics: Adolescent; Adult; Arousal; Attention; Benzhydryl Compounds; Caffeine; Central Nervous System Stimul	2008
Does caffeine change the effect of sleep deprivation on moderate to severe depressed patients? Journal of affective disorders, 2009, Volume: 112, Issue:1-3 Topics: Adult; Ambulatory Care; Caffeine; Circadian Rhythm; Complementary Therapies; Cross-Over Studies; Dep	2009
Feasibility and behavioral effects of an at-home multi-night sleep restriction protocol for adolescents. Journal of child psychology and psychiatry, and allied disciplines, 2008, Volume: 49, Issue:9 Topics: Adolescent; Attention; Body Mass Index; Caffeine; Central Nervous System Stimulants; Cognition Disor	2008
Restoration of risk-propensity during sleep deprivation: caffeine, dextroamphetamine, and modafinil. Aviation, space, and environmental medicine, 2008, Volume: 79, Issue:9 Topics: Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Decision Making	2008
Sleep loss produces false memories. PloS one, 2008, Volume: 3, Issue:10 Topics: Adolescent; Adult; Caffeine; Female; Humans; Hydrocortisone; Learning; Male; Memory Disorders; Menta	2008
Effects of dietary caffeine on EEG, performance and mood when rested and sleep restricted. Human psychopharmacology, 2008, Volume: 23, Issue:8 Topics: Adolescent; Affect; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Diet; Electroen	2008
Modeling fatigue over sleep deprivation, circadian rhythm, and caffeine with a minimal performance inhibitor model. Methods in enzymology, 2009, Volume: 454 Topics: Adult; Caffeine; Circadian Rhythm; Fatigue; Female; Humans; Male; Models, Theoretical; Sleep Depriva	2009
Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil. Sleep, 2009, Volume: 32, Issue:2 Topics: Adolescent; Adult; Arousal; Attention; Benzhydryl Compounds; Caffeine; Central Nervous System Stimul	2009
Effects of caffeine on daytime recovery sleep: A double challenge to the sleep-wake cycle in aging. Sleep medicine, 2009, Volume: 10, Issue:9 Topics: Adult; Age Factors; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Cross-Over Studie	2009
Odor identification ability predicts executive function deficits following sleep deprivation. The International journal of neuroscience, 2010, Volume: 120, Issue:5 Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Dextroamphetamine; Executive Func	2010
Caffeine protects against increased risk-taking propensity during severe sleep deprivation. Journal of sleep research, 2011, Volume: 20, Issue:3 Topics: Adult; Brain; Caffeine; Central Nervous System Stimulants; Female; Humans; Male; Neuropsychological	2011
Effect of caffeine and taurine on simulated laparoscopy performed following sleep deprivation. The British journal of surgery, 2011, Volume: 98, Issue:11 Topics: Caffeine; Central Nervous System Stimulants; Cognition; Computer Simulation; Cross-Over Studies; Gen	2011
Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation. British journal of pharmacology, 2012, Volume: 165, Issue:6 Topics: Adult; Aged; Attention; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cross-Ove	2012
Acute caffeine ingestion's increase of voluntarily chosen resistance-training load after limited sleep. International journal of sport nutrition and exercise metabolism, 2012, Volume: 22, Issue:3 Topics: Adult; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double-Blind Method; Exercis	2012
In-car nocturnal blue light exposure improves motorway driving: a randomized controlled trial. PloS one, 2012, Volume: 7, Issue:10 Topics: Adult; Automobile Driving; Caffeine; Coffee; Cross-Over Studies; Double-Blind Method; Fatigue; Human	2012
A biomathematical model of the restoring effects of caffeine on cognitive performance during sleep deprivation. Journal of theoretical biology, 2013, Feb-21, Volume: 319 Topics: Adult; Caffeine; Central Nervous System Stimulants; Cognition; Female; Humans; Male; Sleep Deprivati	2013
Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology, 2002, Volume: 164, Issue:3 Topics: Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over Studies;	2002
Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology, 2002, Volume: 164, Issue:3 Topics: Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over Studies;	2002
Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology, 2002, Volume: 164, Issue:3 Topics: Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over Studies;	2002
Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology, 2002, Volume: 164, Issue:3 Topics: Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over Studies;	2002
Caffeine effects on marksmanship during high-stress military training with 72 hour sleep deprivation. Aviation, space, and environmental medicine, 2003, Volume: 74, Issue:4 Topics: Adult; Caffeine; Central Nervous System Stimulants; Humans; Male; Markov Chains; Military Personnel;	2003
A comparison of tyrosine against placebo, phentermine, caffeine, and D-amphetamine during sleep deprivation. Nutritional neuroscience, 2003, Volume: 6, Issue:4 Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Dextroamphetamine; Double-Blind Meth	2003
Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation. Nutritional neuroscience, 2003, Volume: 6, Issue:4 Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cognition; Dextroamphetamine; Double	2003
Effects of dietary caffeine on mood when rested and sleep restricted. Human psychopharmacology, 2004, Volume: 19, Issue:5 Topics: Adolescent; Adult; Affect; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Diet; Do	2004
Caffeine attenuates waking and sleep electroencephalographic markers of sleep homeostasis in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:10 Topics: Adult; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double-Blind Method; Electro	2004
Caffeine restores engagement speed but not shooting precision following 22 h of active wakefulness. Aviation, space, and environmental medicine, 2004, Volume: 75, Issue:9 Topics: Adult; Attention; Caffeine; Discrimination, Psychological; Firearms; Humans; Male; Military Medicine	2004
Hemodynamic effects of dietary caffeine, sleep restriction, and laboratory stress. Psychophysiology, 2004, Volume: 41, Issue:6 Topics: Adult; Blood Pressure; Caffeine; Central Nervous System Stimulants; Diet; Female; Heart Rate; Hemody	2004
Recovery after prolonged sleep deprivation: residual effects of slow-release caffeine on recovery sleep, sleepiness and cognitive functions. Neuropsychobiology, 2005, Volume: 51, Issue:1 Topics: Adult; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over Studies; Double-Blind Meth	2005
Caffeine maintains vigilance and marksmanship in simulated urban operations with sleep deprivation. Aviation, space, and environmental medicine, 2005, Volume: 76, Issue:1 Topics: Adult; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Firearms; Humans; Male; Mil	2005
Caffeine effects on recovery sleep following 27 h total sleep deprivation. Aviation, space, and environmental medicine, 2005, Volume: 76, Issue:2 Topics: Adolescent; Adult; Analysis of Variance; Caffeine; Central Nervous System Stimulants; Cross-Over Stu	2005
Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction. Psychopharmacology, 2005, Volume: 179, Issue:4 Topics: Adult; Affect; Attention; Blood Pressure; Caffeine; Central Nervous System Stimulants; Chromatograph	2005
Caffeine maintains vigilance and improves run times during night operations for Special Forces. Aviation, space, and environmental medicine, 2005, Volume: 76, Issue:7 Topics: Adult; Caffeine; Circadian Rhythm; Firearms; Humans; Male; Military Medicine; Military Personnel; Ne	2005
Multiple caffeine doses maintain vigilance during early morning operations. Aviation, space, and environmental medicine, 2005, Volume: 76, Issue:11 Topics: Aerospace Medicine; Analysis of Variance; Caffeine; Central Nervous System Stimulants; Chewing Gum;	2005
Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy. Journal of sleep research, 2006, Volume: 15, Issue:1 Topics: Adult; Arousal; Caffeine; Central Nervous System Stimulants; Cognition Disorders; Double-Blind Metho	2006
The effects of coffee and napping on nighttime highway driving: a randomized trial. Annals of internal medicine, 2006, Jun-06, Volume: 144, Issue:11 Topics: Adult; Automobile Driving; Caffeine; Circadian Rhythm; Coffee; Cross-Over Studies; Double-Blind Meth	2006
The effects of coffee and napping on nighttime highway driving: a randomized trial. Annals of internal medicine, 2006, Jun-06, Volume: 144, Issue:11 Topics: Adult; Automobile Driving; Caffeine; Circadian Rhythm; Coffee; Cross-Over Studies; Double-Blind Meth	2006
The effects of coffee and napping on nighttime highway driving: a randomized trial. Annals of internal medicine, 2006, Jun-06, Volume: 144, Issue:11 Topics: Adult; Automobile Driving; Caffeine; Circadian Rhythm; Coffee; Cross-Over Studies; Double-Blind Meth	2006
The effects of coffee and napping on nighttime highway driving: a randomized trial. Annals of internal medicine, 2006, Jun-06, Volume: 144, Issue:11 Topics: Adult; Automobile Driving; Caffeine; Circadian Rhythm; Coffee; Cross-Over Studies; Double-Blind Meth	2006
The effects of caffeine, dextroamphetamine, and modafinil on humor appreciation during sleep deprivation. Sleep, 2006, Volume: 29, Issue:6 Topics: Adolescent; Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Dex	2006
Effects of caffeine are more marked on daytime recovery sleep than on nocturnal sleep. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:4 Topics: Adult; Analysis of Variance; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Cross-Ov	2007
Adenosinergic mechanisms contribute to individual differences in sleep deprivation-induced changes in neurobehavioral function and brain rhythmic activity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Oct-11, Volume: 26, Issue:41 Topics: Adenosine; Adult; Brain; Caffeine; Cross-Over Studies; Electroencephalography; Humans; Individuality	2006
The effects of chewing versus caffeine on alertness, cognitive performance and cardiac autonomic activity during sleep deprivation. Journal of sleep research, 2006, Volume: 15, Issue:4 Topics: Adolescent; Adult; Arousal; Attention; Autonomic Nervous System; Caffeine; Chewing Gum; Electrocardi	2006
Effects of caffeine on electrophysiological and neuropsychological indices after sleep deprivation. Neuropsychobiology, 2006, Volume: 54, Issue:2 Topics: Adult; Affect; Analysis of Variance; Brain Mapping; Caffeine; Central Nervous System Stimulants; Cog	2006
The effects of 53 hours of sleep deprivation on moral judgment. Sleep, 2007, Volume: 30, Issue:3 Topics: Adult; Caffeine; Chewing Gum; Choice Behavior; Decision Making; Double-Blind Method; Emotions; Femal	2007
Sleep deprivation reduces perceived emotional intelligence and constructive thinking skills. Sleep medicine, 2008, Volume: 9, Issue:5 Topics: Adaptation, Psychological; Adolescent; Adult; Assertiveness; Awareness; Caffeine; Culture; Defense M	2008
Caffeine effects on physical and cognitive performance during sustained operations. Aviation, space, and environmental medicine, 2007, Volume: 78, Issue:9 Topics: Adult; Attention; Caffeine; Central Nervous System Stimulants; Cognition; Exercise Test; Exercise To	2007
Effect of caffeine on simulator flight performance in sleep-deprived military pilot students. Military medicine, 2007, Volume: 172, Issue:9 Topics: Adult; Aerospace Medicine; Aircraft; Caffeine; Central Nervous System Stimulants; Double-Blind Metho	2007
The trait of Introversion-Extraversion predicts vulnerability to sleep deprivation. Journal of sleep research, 2007, Volume: 16, Issue:4 Topics: Adult; Arousal; Attention; Caffeine; Cerebral Cortex; Character; Computers, Handheld; Extraversion,	2007
The effects of modafinil, caffeine, and dextroamphetamine on judgments of simple versus complex emotional expressions following sleep deprivation. The International journal of neuroscience, 2008, Volume: 118, Issue:4 Topics: Adolescent; Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Dex	2008
Effects of acute caffeine withdrawal on Short Category Test performance in sleep-deprived individuals. Perceptual and motor skills, 2007, Volume: 105, Issue:3 Pt 2 Topics: Adult; Caffeine; Cognition Disorders; Concept Formation; Double-Blind Method; Drug Combinations; Eth	2007
Dose-dependent caffeine pharmacokinetics during severe sleep deprivation in humans. International journal of clinical pharmacology and therapeutics, 1995, Volume: 33, Issue:3 Topics: Adolescent; Adult; Caffeine; Chromatography, High Pressure Liquid; Computers; Dose-Response Relation	1995
The use of caffeine versus prophylactic naps in sustained performance. Sleep, 1995, Volume: 18, Issue:2 Topics: Adolescent; Adult; Affect; Body Temperature; Caffeine; Employment; Humans; Male; Placebos; Sleep; Sl	1995
Caffeine reversal of sleep deprivation effects on alertness and mood. Psychopharmacology, 1993, Volume: 112, Issue:2-3 Topics: Adolescent; Adult; Affect; Attention; Caffeine; Double-Blind Method; Humans; Male; Sleep; Sleep Depr	1993
An auditory attention task: a note on the processing of verbal information. Perceptual and motor skills, 1994, Volume: 78, Issue:2 Topics: Adult; Arousal; Attention; Caffeine; Female; Humans; Male; Memory, Short-Term; Problem Solving; Psyc	1994
The use of prophylactic naps and caffeine to maintain performance during a continuous operation. Ergonomics, 1994, Volume: 37, Issue:6 Topics: Adult; Affect; Analysis of Variance; Caffeine; Cognition; Electroencephalography; Humans; Male; Psyc	1994
Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans. Brain research, 1997, Jan-30, Volume: 747, Issue:1 Topics: Adolescent; Adult; Body Temperature; Caffeine; Central Nervous System Stimulants; Depression, Chemic	1997
Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans. Brain research, 1997, Jan-30, Volume: 747, Issue:1 Topics: Adolescent; Adult; Body Temperature; Caffeine; Central Nervous System Stimulants; Depression, Chemic	1997
Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans. Brain research, 1997, Jan-30, Volume: 747, Issue:1 Topics: Adolescent; Adult; Body Temperature; Caffeine; Central Nervous System Stimulants; Depression, Chemic	1997
Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans. Brain research, 1997, Jan-30, Volume: 747, Issue:1 Topics: Adolescent; Adult; Body Temperature; Caffeine; Central Nervous System Stimulants; Depression, Chemic	1997
Combination of bright light and caffeine as a countermeasure for impaired alertness and performance during extended sleep deprivation. Journal of sleep research, 1997, Volume: 6, Issue:1 Topics: Adolescent; Adult; Arousal; Caffeine; Electroencephalography; Humans; Light; Male; Psychomotor Perfo	1997
Combination of bright light and caffeine as a countermeasure for impaired alertness and performance during extended sleep deprivation. Journal of sleep research, 1997, Volume: 6, Issue:1 Topics: Adolescent; Adult; Arousal; Caffeine; Electroencephalography; Humans; Light; Male; Psychomotor Perfo	1997
Combination of bright light and caffeine as a countermeasure for impaired alertness and performance during extended sleep deprivation. Journal of sleep research, 1997, Volume: 6, Issue:1 Topics: Adolescent; Adult; Arousal; Caffeine; Electroencephalography; Humans; Light; Male; Psychomotor Perfo	1997
Combination of bright light and caffeine as a countermeasure for impaired alertness and performance during extended sleep deprivation. Journal of sleep research, 1997, Volume: 6, Issue:1 Topics: Adolescent; Adult; Arousal; Caffeine; Electroencephalography; Humans; Light; Male; Psychomotor Perfo	1997
Sleep latency measures of caffeine effects during sleep deprivation. Electroencephalography and clinical neurophysiology, 1997, Volume: 102, Issue:5 Topics: Adult; Caffeine; Double-Blind Method; Humans; Male; Sleep; Sleep Deprivation; Time Factors	1997
Coffee consumption and total body water homeostasis as measured by fluid balance and bioelectrical impedance analysis. Annals of nutrition & metabolism, 1997, Volume: 41, Issue:1 Topics: Adult; Blood Circulation; Body Water; Body Weight; Caffeine; Coffee; Diuresis; Female; Headache; Hom	1997
Sleep loss and temporal memory. The Quarterly journal of experimental psychology. A, Human experimental psychology, 2000, Volume: 53, Issue:1 Topics: Adolescent; Adult; Caffeine; Double-Blind Method; Female; Humans; Male; Memory, Short-Term; Neuropsy	2000
Slow-release caffeine: a new response to the effects of a limited sleep deprivation. Sleep, 2000, Aug-01, Volume: 23, Issue:5 Topics: Adolescent; Adult; Arousal; Caffeine; Central Nervous System Stimulants; Cognition; Delayed-Action P	2000
Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness. European journal of clinical pharmacology, 2000, Volume: 56, Issue:8 Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Do	2000
Slow-release caffeine as a countermeasure to driver sleepiness induced by partial sleep deprivation. Journal of sleep research, 2001, Volume: 10, Issue:3 Topics: Adult; Affect; Automobile Driving; Caffeine; Central Nervous System Stimulants; Delayed-Action Prepa	2001
Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine. Psychopharmacology, 2002, Volume: 159, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Benzhydryl Compounds; Body Temperatur	2002
Slow release caffeine and prolonged (64-h) continuous wakefulness: effects on vigilance and cognitive performance. Journal of sleep research, 2001, Volume: 10, Issue:4 Topics: Adult; Arousal; Body Temperature; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over	2001

Article	Year
A MULTIFACTORIAL APPROACH FOR IMPROVING THE SURGICAL PERFORMANCE OF NOVICE VITREORETINAL SURGEONS. Retina (Philadelphia, Pa.), 2021, Oct-01, Volume: 41, Issue:10 Topics: Adrenergic beta-Antagonists; Adult; Alcohol Drinking; Blood Alcohol Content; Caffeine; Central Nervo	2021
Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption. Nutrients, 2022, Mar-25, Volume: 14, Issue:7 Topics: Caffeine; Cross-Sectional Studies; Dyslipidemias; Humans; Sleep Apnea, Obstructive; Sleep Deprivatio	2022
Assessment of the unified model of performance: accuracy of group-average and individualised alertness predictions. Journal of sleep research, 2023, Volume: 32, Issue:2 Topics: Attention; Caffeine; Humans; Psychomotor Performance; Sleep Deprivation	2023
Nasal Caffeine Thermo-Sensitive Current drug delivery, 2022, Volume: 20, Issue:1 Topics: Animals; Caffeine; Cognition; Rats; Sleep; Sleep Deprivation	2022
Physiocognitive Modeling: Explaining the Effects of Caffeine on Fatigue. Topics in cognitive science, 2022, Volume: 14, Issue:4 Topics: Caffeine; Fatigue; Humans; Oxygen; Pharmaceutical Preparations; Psychomotor Performance; Sleep Depri	2022
Chronic caffeine consumption improves the acute sleep deprivation-induced spatial memory impairment while altering N-methyl-D-aspartate receptor subunit expression in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2022, Volume: 82, Issue:7 Topics: Animals; Caffeine; Hippocampus; Maze Learning; Memory Disorders; Rats; Rats, Wistar; Receptors, N-Me	2022
Effects of Sleep Deprivation, Non-Dominant Hand Employment, Caffeine and Alcohol Intake During Surgical Performance: Lessons Learned From the Retina Eyesi Virtual Reality Surgical Simulator. Translational vision science & technology, 2022, 08-01, Volume: 11, Issue:8 Topics: Alcohol Drinking; Caffeine; Clinical Competence; Computer Simulation; Employment; Humans; Internship	2022
Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. Neurotoxicity research, 2022, Volume: 40, Issue:6 Topics: Acetylcholinesterase; Animals; Caffeine; Rats; Rats, Long-Evans; Sleep Deprivation; Synaptophysin	2022
Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. Neurotoxicity research, 2022, Volume: 40, Issue:6 Topics: Acetylcholinesterase; Animals; Caffeine; Rats; Rats, Long-Evans; Sleep Deprivation; Synaptophysin	2022
Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. Neurotoxicity research, 2022, Volume: 40, Issue:6 Topics: Acetylcholinesterase; Animals; Caffeine; Rats; Rats, Long-Evans; Sleep Deprivation; Synaptophysin	2022
Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. Neurotoxicity research, 2022, Volume: 40, Issue:6 Topics: Acetylcholinesterase; Animals; Caffeine; Rats; Rats, Long-Evans; Sleep Deprivation; Synaptophysin	2022
Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. Neurotoxicity research, 2022, Volume: 40, Issue:6 Topics: Acetylcholinesterase; Animals; Caffeine; Rats; Rats, Long-Evans; Sleep Deprivation; Synaptophysin	2022
Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. Neurotoxicity research, 2022, Volume: 40, Issue:6 Topics: Acetylcholinesterase; Animals; Caffeine; Rats; Rats, Long-Evans; Sleep Deprivation; Synaptophysin	2022
Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. Neurotoxicity research, 2022, Volume: 40, Issue:6 Topics: Acetylcholinesterase; Animals; Caffeine; Rats; Rats, Long-Evans; Sleep Deprivation; Synaptophysin	2022
Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. Neurotoxicity research, 2022, Volume: 40, Issue:6 Topics: Acetylcholinesterase; Animals; Caffeine; Rats; Rats, Long-Evans; Sleep Deprivation; Synaptophysin	2022
Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. Neurotoxicity research, 2022, Volume: 40, Issue:6 Topics: Acetylcholinesterase; Animals; Caffeine; Rats; Rats, Long-Evans; Sleep Deprivation; Synaptophysin	2022
Discrepancies Between Caregiver Reported Early Childhood Sleep Problems and Clinician Documentation and Referral. Academic pediatrics, 2023, Volume: 23, Issue:6 Topics: Caffeine; Caregivers; Child; Child, Preschool; Female; Humans; Male; Referral and Consultation; Slee	2023
2B-Alert App 2.0: personalized caffeine recommendations for optimal alertness. Sleep, 2023, 07-11, Volume: 46, Issue:7 Topics: Attention; Caffeine; Humans; Mobile Applications; Psychomotor Performance; Reaction Time; Sleep Depr	2023
Caffeine consumption and sleep in a submarine environment: An observational study. Journal of sleep research, 2023, Volume: 32, Issue:5 Topics: Caffeine; Humans; Sleep; Sleep Deprivation; Sleep Initiation and Maintenance Disorders; Wakefulness	2023
The Neuropeptide Galanin Is Required for Homeostatic Rebound Sleep following Increased Neuronal Activity. Neuron, 2019, 10-23, Volume: 104, Issue:2 Topics: 4-Aminopyridine; Aconitine; Animals; Caffeine; Extracellular Signal-Regulated MAP Kinases; GABA Anta	2019
Top 10 evidence-based countermeasures for night shift workers. Emergency medicine journal : EMJ, 2020, Volume: 37, Issue:9 Topics: Caffeine; Circadian Rhythm; Eating; Efficiency; Emergency Service, Hospital; Fatigue; Female; Humans	2020
Caffeine-related effects on cognitive performance: Roles of apoptosis in rat hippocampus following sleep deprivation. Biochemical and biophysical research communications, 2021, 01-01, Volume: 534 Topics: Animals; Apoptosis; Arginine Vasopressin; Caffeine; Central Nervous System Stimulants; Cognition; Co	2021
Coffee effectively attenuates impaired attention in ADORA2A C/C-allele carriers during chronic sleep restriction. Progress in neuro-psychopharmacology & biological psychiatry, 2021, 07-13, Volume: 109 Topics: Adult; Alleles; Attention; Caffeine; Coffee; Double-Blind Method; Female; Humans; Male; Neuropsychol	2021
Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study. Scientific reports, 2021, 02-17, Volume: 11, Issue:1 Topics: Adult; Attention; Caffeine; Cognition; Double-Blind Method; Fatigue; Female; Humans; Male; Neuropsyc	2021
Sleep deprivation reduces vagal tone during an inspiratory endurance task in humans. Sleep, 2021, 10-11, Volume: 44, Issue:10 Topics: Caffeine; Heart Rate; Humans; Sleep; Sleep Deprivation; Vagus Nerve	2021
The viability of an ecologically valid chronic sleep restriction and circadian timing protocol: An examination of sample attrition, compliance, and effectiveness at impacting sleepiness and mood. PloS one, 2017, Volume: 12, Issue:3 Topics: Actigraphy; Adolescent; Adult; Affect; Anxiety; Behavior; Caffeine; Circadian Rhythm; Depression; Fe	2017
Decreased alertness due to sleep loss increases pain sensitivity in mice. Nature medicine, 2017, Volume: 23, Issue:6 Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Chronic Diseas	2017
Sensorimotor and executive function slowing in anesthesiology residents after overnight shifts. Journal of clinical anesthesia, 2017, Volume: 40 Topics: Adult; After-Hours Care; Anesthesiologists; Caffeine; Executive Function; Female; Humans; Internship	2017
A survey of the prevalence of fatigue, its precursors and individual coping mechanisms among U.S. manufacturing workers. Applied ergonomics, 2017, Volume: 65 Topics: Adaptation, Psychological; Adult; Ankle; Asthenopia; Back; Caffeine; Communication; Cross-Sectional	2017
Preemptive Caffeine Administration Blocks the Increase in Postoperative Pain Caused by Previous Sleep Loss in the Rat: A Potential Role for Preoptic Adenosine A2A Receptors in Sleep-Pain Interactions. Sleep, 2017, 09-01, Volume: 40, Issue:9 Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Female; Hyperalgesia; Male; Pain, Postoperativ	2017
Limited Efficacy of Caffeine and Recovery Costs During and Following 5 Days of Chronic Sleep Restriction. Sleep, 2017, 12-01, Volume: 40, Issue:12 Topics: Adult; Arousal; Attention; Caffeine; Female; Humans; Male; Polysomnography; Psychomotor Performance;	2017
Sleep deprivation negatively impacts reproductive output in The Journal of experimental biology, 2018, 03-26, Volume: 221, Issue:Pt 6 Topics: Animals; Caffeine; Central Nervous System Stimulants; Drosophila melanogaster; Female; Models, Anima	2018
Coping with shift work-related circadian disruption: A mixed-methods case study on napping and caffeine use in Australian nurses and midwives. Chronobiology international, 2018, Volume: 35, Issue:6 Topics: Adaptation, Psychological; Adult; Aged; Australia; Caffeine; Circadian Rhythm; Female; Humans; Male;	2018
Caffeine dosing strategies to optimize alertness during sleep loss. Journal of sleep research, 2018, Volume: 27, Issue:5 Topics: Adult; Caffeine; Central Nervous System Stimulants; Female; Humans; Male; Psychomotor Performance; S	2018
Effects of chronic caffeine consumption on sleep and the sleep electroencephalogram in mice. Journal of psychopharmacology (Oxford, England), 2019, Volume: 33, Issue:1 Topics: Animals; Caffeine; Central Nervous System Stimulants; Electroencephalography; Male; Mice; Mice, Inbr	2019
Endogenous Nitric Oxide Inhibits, Whereas Awakening Stimuli Increase, the Activity of a Subset of Orexin Neurons. Biological & pharmaceutical bulletin, 2018, Volume: 41, Issue:12 Topics: Animals; Arousal; Caffeine; Central Nervous System Stimulants; Diphenhydramine; Male; Mice, Inbred C	2018
"Let's talk about sleep": a qualitative examination of levers for promoting healthy sleep among sleep-deprived vulnerable adolescents. Sleep medicine, 2019, Volume: 60 Topics: Adolescent; Awareness; Boston; Caffeine; Cell Phone; Exercise; Female; Focus Groups; Humans; Male; P	2019
Caffeine as a potential arousal enhancer: altered NMDA subunit gene expression without improving cognitive performance in REM sleep deprived rats. Cellular and molecular biology (Noisy-le-Grand, France), 2019, Feb-28, Volume: 65, Issue:2 Topics: Animals; Arousal; Caffeine; Chronic Disease; Cognition; Gene Expression Regulation; Maze Learning; M	2019
Pharmacological Modulation of Sleep Homeostasis in Rat: Novel Effects of an mGluR2/3 Antagonist. Sleep, 2019, 09-06, Volume: 42, Issue:9 Topics: Amino Acids; Animals; Caffeine; Central Nervous System Stimulants; Cyclohexanes; Dextroamphetamine;	2019
Assessment and comparison of sleep patterns among medical and non-medical undergraduates of Karachi: A cross-sectional study - SPECIAL REPORT. JPMA. The Journal of the Pakistan Medical Association, 2019, Volume: 69, Issue:6 Topics: Adolescent; Adult; Attention; Caffeine; Cell Phone; Cross-Sectional Studies; Female; Humans; Male; P	2019
Caffeine and modafinil promote adult neuronal cell proliferation during 48 h of total sleep deprivation in rat dentate gyrus. Experimental neurology, 2013, Volume: 248 Topics: Animals; Benzhydryl Compounds; Brain-Derived Neurotrophic Factor; Caffeine; Cell Count; Cell Prolife	2013
Changes in behavior of evoked potentials in the brain as a possible indicator of fatigue in people. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2013, Volume: 2013 Topics: Adult; Algorithms; Brain; Brain-Computer Interfaces; Caffeine; Electroencephalography; Evoked Potent	2013
The effects of caffeine ingestion on the reaction time and short-term maximal performance after 36 h of sleep deprivation. Physiology & behavior, 2014, May-28, Volume: 131 Topics: Affect; Body Temperature; Caffeine; Central Nervous System Stimulants; Cognition; Fatigue; Humans; M	2014
Dose-dependent model of caffeine effects on human vigilance during total sleep deprivation. Journal of theoretical biology, 2014, Oct-07, Volume: 358 Topics: Attention; Caffeine; Dose-Response Relationship, Drug; Humans; Sleep Deprivation	2014
Caffeine increases light responsiveness of the mouse circadian pacemaker. The European journal of neuroscience, 2014, Volume: 40, Issue:10 Topics: Actigraphy; Animals; Caffeine; Central Nervous System Stimulants; Circadian Clocks; Cross-Over Studi	2014
You're the Flight Surgeon: aviator with brief psychotic episode. Aerospace medicine and human performance, 2015, Volume: 86, Issue:1 Topics: Adult; Aerospace Medicine; Caffeine; Humans; Male; Military Personnel; Paranoid Disorders; Return to	2015
Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617. Psychopharmacology, 2015, Volume: 232, Issue:21-22 Topics: Animals; Arousal; Benzhydryl Compounds; Biofeedback, Psychology; Caffeine; Central Nervous System St	2015
Caffeine and modafinil given during 48 h sleep deprivation modulate object recognition memory and synaptic proteins in the hippocampus of the rat. Behavioural brain research, 2015, Nov-01, Volume: 294 Topics: Animals; Benzhydryl Compounds; Caffeine; Disease Models, Animal; Disks Large Homolog 4 Protein; Drug	2015
Sleep extension improves serving accuracy: A study with college varsity tennis players. Physiology & behavior, 2015, Nov-01, Volume: 151 Topics: Adolescent; Athletes; Athletic Performance; Caffeine; Female; Humans; Male; Sleep; Sleep Deprivation	2015
Caffeine treatment prevents rapid eye movement sleep deprivation-induced impairment of late-phase long-term potentiation in the dentate gyrus. The European journal of neuroscience, 2015, Volume: 42, Issue:10 Topics: Animals; Brain Waves; Brain-Derived Neurotrophic Factor; Caffeine; Calcium-Calmodulin-Dependent Prot	2015
Sleep Deprivation Impairs and Caffeine Enhances My Performance, but Not Always Our Performance. Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc, 2017, Volume: 21, Issue:1 Topics: Caffeine; Group Processes; Humans; Motivation; Psychomotor Performance; Sleep; Sleep Deprivation	2017
Caffeine and REM sleep deprivation: Effect on basal levels of signaling molecules in area CA1. Molecular and cellular neurosciences, 2016, Volume: 71 Topics: Animals; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Caffeine; Calcium-Calmodulin-De	2016
A Unified Model of Performance for Predicting the Effects of Sleep and Caffeine. Sleep, 2016, Oct-01, Volume: 39, Issue:10 Topics: Adolescent; Adult; Caffeine; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; M	2016
Adenosine A1 receptor antagonist mitigates deleterious effects of sleep deprivation on adult neurogenesis and spatial reference memory in rats. Neuroscience, 2016, Nov-19, Volume: 337 Topics: Adenosine A1 Receptor Antagonists; Aging; Animals; Caffeine; Doublecortin Protein; Hippocampus; Male	2016
Homeostatic response to sleep/rest deprivation by constant water flow in larval zebrafish in both dark and light conditions. Journal of sleep research, 2017, Volume: 26, Issue:3 Topics: Adenosine; Animals; Arousal; Caffeine; Circadian Rhythm; Darkness; Homeostasis; Larva; Light; Models	2017
Baseline odor identification ability predicts degradation of psychomotor vigilance during 77 hours of sleep deprivation. The International journal of neuroscience, 2008, Volume: 118, Issue:9 Topics: Adult; Aptitude; Arousal; Caffeine; Double-Blind Method; Female; Humans; Male; Odorants; Predictive	2008
Sex differences in cognitive estimation during sleep deprivation: effects of stimulant countermeasures. The International journal of neuroscience, 2008, Volume: 118, Issue:11 Topics: Adenosine; Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Cogn	2008
Adolescents living the 24/7 lifestyle: effects of caffeine and technology on sleep duration and daytime functioning. Pediatrics, 2009, Volume: 123, Issue:6 Topics: Adolescent; Attention; Caffeine; Child; Circadian Rhythm; Female; Health Surveys; Humans; Life Style	2009
Seasonal sleep effects on Louisiana aerial applicators' safety. Journal of agricultural safety and health, 2010, Volume: 16, Issue:1 Topics: Accidents, Aviation; Accidents, Occupational; Adult; Aged; Agriculture; Aircraft; Alcohol Drinking;	2010
Caffeine prevents sleep loss-induced deficits in long-term potentiation and related signaling molecules in the dentate gyrus. The European journal of neuroscience, 2010, Volume: 31, Issue:8 Topics: Administration, Oral; Animals; Brain-Derived Neurotrophic Factor; Caffeine; Calcium-Calmodulin-Depen	2010
Chronic caffeine treatment prevents sleep deprivation-induced impairment of cognitive function and synaptic plasticity. Sleep, 2010, Volume: 33, Issue:4 Topics: Animals; Behavior, Animal; Caffeine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Ner	2010
Patterns and consequences of inadequate sleep in college students: substance use and motor vehicle accidents. The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2010, Volume: 46, Issue:6 Topics: Accidents, Traffic; Adolescent; Caffeine; Cross-Sectional Studies; Female; Humans; Male; Sleep Depri	2010
Adolescent substance use, sleep, and academic achievement: evidence of harm due to caffeine. Journal of adolescence, 2011, Volume: 34, Issue:4 Topics: Adolescent; Adolescent Behavior; Caffeine; Central Nervous System Stimulants; Cross-Sectional Studie	2011
Incorporation of caffeine into a quantitative model of fatigue and sleep. Journal of theoretical biology, 2011, Mar-21, Volume: 273, Issue:1 Topics: Caffeine; Dose-Response Relationship, Drug; Fatigue; Humans; Models, Biological; Sleep; Sleep Depriv	2011
Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: protection by caffeine. Molecular and cellular neurosciences, 2011, Volume: 46, Issue:4 Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Caffeine; Cyclic AMP Response Element-Binding Pro	2011
Sleep debt--Where is the answer--in or outside the laboratory? Biological psychology, 2011, Volume: 87, Issue:2 Topics: Accidents, Traffic; Caffeine; Central Nervous System Stimulants; Epidemiologic Methods; Humans; Indi	2011
Sleep, stress and compensatory behaviors in Australian nurses and midwives. Revista de saude publica, 2011, Volume: 45, Issue:5 Topics: Adult; Australia; Burnout, Professional; Caffeine; Central Nervous System Stimulants; Female; Humans	2011
Gambling when sleep deprived: don't bet on stimulants. Chronobiology international, 2012, Volume: 29, Issue:1 Topics: Adolescent; Adult; Arousal; Caffeine; Central Nervous System Stimulants; Cognition; Decision Making;	2012
A case of acute suicidality following excessive caffeine intake. Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:11 Topics: Adult; Caffeine; Energy Drinks; Humans; Male; Sleep Deprivation; Suicide, Attempted	2012
Reduced sleep and low adenosinergic sensitivity in cacna1a R192Q mutant mice. Sleep, 2013, Jan-01, Volume: 36, Issue:1 Topics: Adenosine; Analysis of Variance; Animals; Caffeine; Central Nervous System Stimulants; Cross-Over St	2013
Chronic stress undermines the compensatory sleep efficiency increase in response to sleep restriction in adolescents. Journal of sleep research, 2013, Volume: 22, Issue:4 Topics: Actigraphy; Adolescent; Alcohol Drinking; Caffeine; Educational Measurement; Fatigue; Female; Health	2013
SLEEP (Sleep Loss Effects On Everyday Performance) Model. Aviation, space, and environmental medicine, 2004, Volume: 75, Issue:3 Suppl Topics: Alcohol Drinking; Caffeine; Fatigue; Health Knowledge, Attitudes, Practice; Homeostasis; Humans; Mod	2004
On the importance of countermeasures in sleep and performance models. Aviation, space, and environmental medicine, 2004, Volume: 75, Issue:3 Suppl Topics: Caffeine; Circadian Rhythm; Drug Tolerance; Fatigue; Humans; Models, Biological; Sleep; Sleep Depriv	2004
Modafinil vs. caffeine: effects on fatigue during sleep deprivation. Aviation, space, and environmental medicine, 2004, Volume: 75, Issue:6 Topics: Adolescent; Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Dose-Response	2004
Drosophila melanogaster: an insect model for fundamental studies of sleep. Methods in enzymology, 2005, Volume: 393 Topics: Animals; Arousal; Caffeine; Circadian Rhythm; Cyclic AMP Response Element-Binding Protein; Drosophil	2005
Dietary caffeine, performance and mood: enhancing and restorative effects after controlling for withdrawal reversal. Neuropsychobiology, 2005, Volume: 52, Issue:1 Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Central Nervous System Stimulants; Diet; Female; Human	2005
Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation. Journal of sleep research, 2005, Volume: 14, Issue:3 Topics: Adult; Arousal; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Dextro	2005
What are caffeine's psychological benefits and risks? The Harvard mental health letter, 2005, Volume: 22, Issue:3 Topics: Caffeine; Central Nervous System Stimulants; Humans; Sleep; Sleep Deprivation; Substance Withdrawal	2005
Caffeine challenge in insomniac patients after total sleep deprivation. Sleep medicine, 2006, Volume: 7, Issue:2 Topics: Adult; Caffeine; Central Nervous System Stimulants; Delta Rhythm; Diagnostic and Statistical Manual	2006
Summaries for patients. Coffee and napping improve nighttime highway driving. Annals of internal medicine, 2006, Jun-06, Volume: 144, Issue:11 Topics: Adult; Automobile Driving; Caffeine; Circadian Rhythm; Coffee; Cross-Over Studies; Double-Blind Meth	2006
Naps and drugs to combat fatigue and sleepiness. Annals of internal medicine, 2006, Jun-06, Volume: 144, Issue:11 Topics: Caffeine; Coffee; Fatigue; Humans; Sleep; Sleep Deprivation	2006
Effects of different substance misuse in genital reflexes of paradoxical sleep deprived male rats. Scandinavian journal of psychology, 2007, Volume: 48, Issue:3 Topics: Analysis of Variance; Animals; Caffeine; Central Nervous System Depressants; Central Nervous System	2007
Caffeine effects on risky decision making after 75 hours of sleep deprivation. Aviation, space, and environmental medicine, 2007, Volume: 78, Issue:10 Topics: Adult; Analysis of Variance; Arousal; Caffeine; Cognition Disorders; Decision Making; Female; Gambli	2007
Perception of simulated driving performance after sleep restriction and caffeine. Journal of psychosomatic research, 2007, Volume: 63, Issue:6 Topics: Adult; Automobile Driving; Caffeine; Central Nervous System Stimulants; Female; Humans; Male; Percep	2007
Placebo response to caffeine improves reaction time performance in sleepy people. Human psychopharmacology, 2008, Volume: 23, Issue:4 Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Coffee; Female; Humans; Male; Motiva	2008
Caffeine produces REM sleep rebound in rats. Brain research, 1980, Nov-17, Volume: 201, Issue:2 Topics: Animals; Caffeine; Male; Rats; Sleep Deprivation; Sleep, REM	1980
Effects of N6-cyclopentyladenosine and caffeine on sleep regulation in the rat. European journal of pharmacology, 1996, Apr-11, Volume: 300, Issue:3 Topics: Adenosine; Animals; Caffeine; Central Nervous System Stimulants; Electroencephalography; Male; Rats;	1996
Sleep after arousal from hibernation is not homeostatically regulated. The American journal of physiology, 1999, Volume: 276, Issue:2 Topics: Animals; Arousal; Caffeine; Central Nervous System Stimulants; Electroencephalography; Handling, Psy	1999
[Headache and chronic sleep deprivation: an often missed relationship in children and also in adults]. Nederlands tijdschrift voor geneeskunde, 1999, Dec-11, Volume: 143, Issue:50 Topics: Adult; Caffeine; Central Nervous System Stimulants; Child; Fatigue; Female; Headache; Humans; Male;	1999
Caffeine during sleep deprivation: sleep tendency and dynamics of recovery sleep in rats. Pharmacology, biochemistry, and behavior, 2000, Jan-01, Volume: 65, Issue:1 Topics: Animals; Caffeine; Circadian Rhythm; Male; Rats; Rats, Wistar; Sleep; Sleep Deprivation; Sleep, REM;	2000
Combating fatigue to enhance safety. Aviation week & space technology, 1996, Nov-04, Volume: 145, Issue:19 Topics: Accidents, Aviation; Aerospace Medicine; Caffeine; Circadian Rhythm; Ergonomics; Fatigue; Humans; Me	1996
Adenosine and caffeine modulate circadian rhythms in the Syrian hamster. Neuroreport, 2001, Sep-17, Volume: 12, Issue:13 Topics: Adenosine; Animals; Caffeine; Circadian Rhythm; Cricetinae; Dose-Response Relationship, Drug; Immuno	2001
Sleep deprivation, drug use, and psychiatric disorders. AJS; American journal of sociology, 1972, Volume: 77, Issue:5 Topics: Caffeine; Ethanol; Humans; Mental Disorders; Sleep; Sleep Deprivation	1972

caffeine and Inadequate Sleep

Research Excerpts

Research

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