caffeine has been researched along with Hypoxia in 136 studies
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of caffeine on performance, neuromuscular fatigue and perception of effort during high-intensity cycling exercise in moderate hypoxia." | 9.24 | Effects of caffeine on neuromuscular fatigue and performance during high-intensity cycling exercise in moderate hypoxia. ( Angius, L; de Moraes, AC; Marcora, SM; Smirmaul, BP, 2017) |
| "To study the effect of doxapram on the frequency of apnoea, bradycardia and hypoxaemia." | 9.09 | Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants. ( Bohnhorst, B; Darraj, S; Poets, CF, 1999) |
| "The effect of oral caffeine on resting ventilation (VE), ventilatory responsiveness to progressive hyperoxic hypercapnia (HCVR), isocapnic hypoxia (HVR), and moderate exercise (EVR) below the anaerobic threshold (AT) was examined in seven healthy adults." | 9.06 | Effect of caffeine on ventilatory responses to hypercapnia, hypoxia, and exercise in humans. ( Avendano, MA; D'Costa, M; D'Urzo, AD; Goldstein, RS; Jenne, H; Jhirad, R; Rubenstein, I; Rubinstein, I, 1990) |
| "The respiratory stimulant caffeine is the most frequently used xanthine (theophylline or aminophylline) for the treatment of apnea in premature infants." | 8.91 | An Overview on the Respiratory Stimulant Effects of Caffeine and Progesterone on Response to Hypoxia and Apnea Frequency in Developing Rats. ( Bairam, A; Joseph, V; Mubayed, S; Uppari, N, 2015) |
| "Apnea of prematurity (AOP) is a significant clinical problem manifested by an unstable respiratory rhythm reflecting the immaturity of respiratory control systems." | 8.87 | Apnea of prematurity: pathogenesis and management strategies. ( Mathew, OP, 2011) |
| " Similarly, the consumption of caffeine antagonizes A2ARs, resulting in exacerbation of ongoing acute inflammation." | 8.85 | The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells. ( Belikoff, B; Hatfield, S; Lukashev, D; Ohta, A; Sitkovsky, M, 2009) |
| " We propose that tumor protection is to a large extent due to (a) inhibition of antitumor T cells by hypoxia-driven accumulation of extracellular adenosine in local tumor microenvironment and due to (b) T regulatory cell-produced extracellular adenosine." | 8.84 | Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia. ( Kjaergaard, J; Lukashev, D; Ohta, A; Sitkovsky, MV, 2008) |
| " Caffeine therapy for central sleep apnea, hypoxemia, and hypoventilation in a term neonate." | 8.31 | Images: Caffeine therapy for central sleep apnea, hypoxemia, and hypoventilation in a term neonate. ( Kasi, AS; Leu, RM; Martinez, F; Shah, AS; Shah, SP, 2023) |
| "Thirty rats with glioma were divided into control group, temozolomide (TMZ) group (TMZ 30 mg/kg once daily for 5 day), and TMZ plus Caffeine group (TMZ 30 mg/kg once daily for 5 day and caffeine 100 mg/kg once daily for 2 weeks)." | 8.12 | Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats. ( Chen, JC; Hwang, JH, 2022) |
| " Results suggest an additive negative effect of maternal caffeine on the fetal CV response to acute maternal hypoxia, potentially mediated via adenosine A(2A) receptor inhibition during primary cardiovascular morphogenesis." | 7.78 | Maternal hypoxia and caffeine exposure depress fetal cardiovascular function during primary organogenesis. ( Keller, BB; Momoi, N; Tinney, JP; Tobita, K, 2012) |
| "The mechanisms underlying the therapeutic function of caffeine on apneas in preterm neonates are not well determined." | 7.76 | Caffeine reduces apnea frequency and enhances ventilatory long-term facilitation in rat pups raised in chronic intermittent hypoxia. ( Bairam, A; Joseph, V; Julien, CA, 2010) |
| "Caffeine is a common treatment for apnea of prematurity." | 7.75 | Enhancement of the breathing frequency response to hypoxia by neonatal caffeine treatment in adult male rats: the role of testosterone. ( Bairam, A; Joseph, V; Kinkead, R; Lajeunesse, Y; Montandon, G, 2009) |
| "To elucidate the mechanisms of CBF augmentation during hypoxemic hypoxia, we applied continuous monitoring of CBF and metabolism to examine the participation of prostacyclin, nitric oxide (NO), and/or adenosine in these mechanisms." | 7.69 | Mechanisms of CBF augmentation during hypoxia in cats: probable participation of prostacyclin, nitric oxide and adenosine. ( Fukuuchi, Y; Isozumi, K; Itoh, Y; Takeda, H, 1994) |
| "The Ca2+ sensitivity of cardiac myofibrillar force production can be decreased by acidosis or inorganic phosphate (P(i)) and increased by caffeine." | 7.69 | Developmental differences and regional similarities in the responses of rat cardiac skinned muscles to acidosis, inorganic phosphate and caffeine. ( Kentish, JC; Palmer, S, 1996) |
| "The effects of adenosinergic antagonists caffeine and DPCPX, and of the adenosinergic agonists L-PIA, CPA and CGS 21680 were investigated on fully and partially reversible hypoxia-induced electrophysiological changes in rat hippocampal slices." | 7.68 | Effects of adenosinergic drugs on hypoxia-induced electrophysiological changes in rat hippocampal slices. ( Domenici, MR; Frank, C; Sagratella, S; Scotti de Carolis, A; Zeng, YC, 1992) |
| "This study characterized in rhesus monkeys the effects of selected adenosine agonists on ventilation during normal atmospheric conditions and during conditions of hypercapnia, hypoxia and hyperoxia." | 7.68 | Effects of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys. ( Howell, LL, 1993) |
| "The efficacy of low and high dose caffeine on idiopathic bradycardia and hypoxaemia was tested in premature infants." | 7.67 | [Effectiveness of low- and high-dose caffeine on idiopathic bradycardia and hypoxemia in premature infants]. ( Bucher, HU; Duc, G; Fallenstein, F; Mieth, D, 1985) |
| " However, varying oxygen environments, such as Hx or neonatal IH, may alter and modify pharmacodynamic actions of caffeine and may even override the benefits caffeine." | 5.62 | Pharmacodynamic Effects of Standard versus High Caffeine Doses in the Developing Brain of Neonatal Rats Exposed to Intermittent Hypoxia. ( Ahmad, T; Aranda, JV; Beharry, KD; Cai, CL; Hand, I; Soontarapornchai, K, 2021) |
| "A stroke-like event follows seizures which may be responsible for the postictal state and a contributing factor to the development of seizure-induced brain abnormalities and behavioral dysfunction associated with epilepsy." | 5.51 | Caffeine Exacerbates Postictal Hypoxia. ( Gom, RC; Phillips, TJ; Teskey, GC; Wolff, MD, 2019) |
| "Caffeine was administered in drinking water (1 mg/ml)." | 5.38 | Chronic caffeine intake in adult rat inhibits carotid body sensitization produced by chronic sustained hypoxia but maintains intact chemoreflex output. ( Conde, SV; Gonzalez, C; Monteiro, EC; Obeso, A; Ribeiro, MJ; Rigual, R, 2012) |
| "Caffeine is a widely used psychostimulant freely crossing the placental barrier." | 5.35 | Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar hypoxia in newborn rats and adenosine A2A and GABA A receptor mRNA transcription. ( Guénin, S; Larnicol, N; Perrin, Y; Picard, N, 2008) |
| "To investigate the effects of caffeine on performance, neuromuscular fatigue and perception of effort during high-intensity cycling exercise in moderate hypoxia." | 5.24 | Effects of caffeine on neuromuscular fatigue and performance during high-intensity cycling exercise in moderate hypoxia. ( Angius, L; de Moraes, AC; Marcora, SM; Smirmaul, BP, 2017) |
| "To study the effect of doxapram on the frequency of apnoea, bradycardia and hypoxaemia." | 5.09 | Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants. ( Bohnhorst, B; Darraj, S; Poets, CF, 1999) |
| "The effect of oral caffeine on resting ventilation (VE), ventilatory responsiveness to progressive hyperoxic hypercapnia (HCVR), isocapnic hypoxia (HVR), and moderate exercise (EVR) below the anaerobic threshold (AT) was examined in seven healthy adults." | 5.06 | Effect of caffeine on ventilatory responses to hypercapnia, hypoxia, and exercise in humans. ( Avendano, MA; D'Costa, M; D'Urzo, AD; Goldstein, RS; Jenne, H; Jhirad, R; Rubenstein, I; Rubinstein, I, 1990) |
| " Despite aggressive respiratory support including mechanical ventilation, continuous positive airway pressure, oxygen and caffeine therapy to reduce apnea and accompanying intermittent hypoxemia, the incidence of intermittent hypoxemia events continues to increase during the first few months of life." | 4.93 | Cardiorespiratory events in preterm infants: interventions and consequences. ( Di Fiore, JM; Gauda, E; MacFarlane, P; Martin, RJ; Poets, CF, 2016) |
| "The respiratory stimulant caffeine is the most frequently used xanthine (theophylline or aminophylline) for the treatment of apnea in premature infants." | 4.91 | An Overview on the Respiratory Stimulant Effects of Caffeine and Progesterone on Response to Hypoxia and Apnea Frequency in Developing Rats. ( Bairam, A; Joseph, V; Mubayed, S; Uppari, N, 2015) |
| "Apnea of prematurity (AOP) is a significant clinical problem manifested by an unstable respiratory rhythm reflecting the immaturity of respiratory control systems." | 4.87 | Apnea of prematurity: pathogenesis and management strategies. ( Mathew, OP, 2011) |
| " Similarly, the consumption of caffeine antagonizes A2ARs, resulting in exacerbation of ongoing acute inflammation." | 4.85 | The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells. ( Belikoff, B; Hatfield, S; Lukashev, D; Ohta, A; Sitkovsky, M, 2009) |
| " We propose that tumor protection is to a large extent due to (a) inhibition of antitumor T cells by hypoxia-driven accumulation of extracellular adenosine in local tumor microenvironment and due to (b) T regulatory cell-produced extracellular adenosine." | 4.84 | Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia. ( Kjaergaard, J; Lukashev, D; Ohta, A; Sitkovsky, MV, 2008) |
| " Caffeine therapy for central sleep apnea, hypoxemia, and hypoventilation in a term neonate." | 4.31 | Images: Caffeine therapy for central sleep apnea, hypoxemia, and hypoventilation in a term neonate. ( Kasi, AS; Leu, RM; Martinez, F; Shah, AS; Shah, SP, 2023) |
| "Caffeine is widely used in preterm infants for apnea control." | 4.12 | Caffeine is a respiratory stimulant without effect on sleep in the short-term in late-preterm infants. ( Andersson, S; Kirjavainen, T; Seppä-Moilanen, M, 2022) |
| "Thirty rats with glioma were divided into control group, temozolomide (TMZ) group (TMZ 30 mg/kg once daily for 5 day), and TMZ plus Caffeine group (TMZ 30 mg/kg once daily for 5 day and caffeine 100 mg/kg once daily for 2 weeks)." | 4.12 | Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats. ( Chen, JC; Hwang, JH, 2022) |
| "A frequent challenge in Neonatology is the high frequency of spontaneously occurring hypoxemic events, a majority of which are associated with apnea or hypoventilation." | 4.02 | Are we over-treating hypoxic spells in preterm infants? ( Conlon, S; Di Fiore, JM; Martin, RJ, 2021) |
| " It appears that infants with apnea of prematurity and those receiving assisted ventilation are the most likely to benefit from caffeine." | 3.96 | When to start and stop caffeine and why respiratory status matters. ( Davis, PG, 2020) |
| "BACKGROUND We aimed to explore the involvement of adenosine 1 adenosine receptor (A1AR) in hypoxia-induced poor differentiation of oligodendrocytes (OLs), and the underlying mechanism of caffeine treatment in hypoxic injuries." | 3.91 | Caffeine Treatment Promotes Differentiation and Maturation of Hypoxic Oligodendrocytes via Counterbalancing Adenosine 1 Adenosine Receptor-Induced Calcium Overload. ( Cai, Q; Cao, T; Li, B; Li, H; Ma, T; Tian, Y; Xu, Y, 2019) |
| "We recently showed that in 12-day-old male rats exposed to caffeine for 10 consecutive days, progesterone inhibits the respiratory response to hypoxia and increases apnea frequency (Uppari et al." | 3.85 | Respiratory responses to progesterone and allopregnanolone following chronic caffeine treatment in newborn female rats. ( Bairam, A; Joseph, V; Uppari, NP, 2017) |
| " Herein, we have investigated the significance of adenosine, through the blockade of its receptors with caffeine, on the CB hypoxic sensitization induced by chronic intermittent hypoxia (CIH) in the rat." | 3.81 | Adenosine Receptor Blockade by Caffeine Inhibits Carotid Sinus Nerve Chemosensory Activity in Chronic Intermittent Hypoxic Animals. ( Conde, SV; Gonzalez, C; Gonzalez-Martin, MC; Sacramento, JF, 2015) |
| " Results suggest an additive negative effect of maternal caffeine on the fetal CV response to acute maternal hypoxia, potentially mediated via adenosine A(2A) receptor inhibition during primary cardiovascular morphogenesis." | 3.78 | Maternal hypoxia and caffeine exposure depress fetal cardiovascular function during primary organogenesis. ( Keller, BB; Momoi, N; Tinney, JP; Tobita, K, 2012) |
| "These data show that caffeine alters embryonic cardiac function and disrupts the normal cardiac response to hypoxia through blockade of A1AR action." | 3.77 | Caffeine acts via A1 adenosine receptors to disrupt embryonic cardiac function. ( Breuer, GA; Buscariollo, DL; Rivkees, SA; Wendler, CC, 2011) |
| "The mechanisms underlying the therapeutic function of caffeine on apneas in preterm neonates are not well determined." | 3.76 | Caffeine reduces apnea frequency and enhances ventilatory long-term facilitation in rat pups raised in chronic intermittent hypoxia. ( Bairam, A; Joseph, V; Julien, CA, 2010) |
| "Caffeine is a common treatment for apnea of prematurity." | 3.75 | Enhancement of the breathing frequency response to hypoxia by neonatal caffeine treatment in adult male rats: the role of testosterone. ( Bairam, A; Joseph, V; Kinkead, R; Lajeunesse, Y; Montandon, G, 2009) |
| " The nonphysiological effector caffeine and the physiological modulator urate, the latter accumulating in the hemolymph of the lobster Homarus vulgaris during hypoxia, increase hemocyanin oxygen affinity and decrease cooperativity of oxygen binding." | 3.73 | Allosteric models for multimeric proteins: oxygen-linked effector binding in hemocyanin. ( Decker, H; Grieshaber, MK; Hellmann, N; Menze, MA, 2005) |
| "The observed effect of hypoxia-induced vasodilatation in peripheral arteries may be the result of the vasodilatory effect of elevated endogenous adenosine during hypoxia." | 3.72 | The effect of caffeine on peripheral vascular resistance in isolated perfused guinea pig hind limbs. ( Brodmann, M; Lischnig, U; Lueger, A; Pilger, E; Stark, G, 2003) |
| "The Ca2+ sensitivity of cardiac myofibrillar force production can be decreased by acidosis or inorganic phosphate (P(i)) and increased by caffeine." | 3.69 | Developmental differences and regional similarities in the responses of rat cardiac skinned muscles to acidosis, inorganic phosphate and caffeine. ( Kentish, JC; Palmer, S, 1996) |
| "To elucidate the mechanisms of CBF augmentation during hypoxemic hypoxia, we applied continuous monitoring of CBF and metabolism to examine the participation of prostacyclin, nitric oxide (NO), and/or adenosine in these mechanisms." | 3.69 | Mechanisms of CBF augmentation during hypoxia in cats: probable participation of prostacyclin, nitric oxide and adenosine. ( Fukuuchi, Y; Isozumi, K; Itoh, Y; Takeda, H, 1994) |
| "The role of intracerebral adenosine levels in the control of ventilatory response to hypoxia was explored in 15 spontaneously breathing intubated piglets, 1-5 days old, sedated with chloral hydrate." | 3.69 | Role of adenosine in the hypoxic ventilatory response of the newborn piglet. ( Aranda, JV; Davis, GM; Lopes, JM; Mullahoo, K, 1994) |
| "The effects of adenosinergic antagonists caffeine and DPCPX, and of the adenosinergic agonists L-PIA, CPA and CGS 21680 were investigated on fully and partially reversible hypoxia-induced electrophysiological changes in rat hippocampal slices." | 3.68 | Effects of adenosinergic drugs on hypoxia-induced electrophysiological changes in rat hippocampal slices. ( Domenici, MR; Frank, C; Sagratella, S; Scotti de Carolis, A; Zeng, YC, 1992) |
| "Hypoxia caused a progressive cytochalasin B-inhibitable increase in the rate of 3-O-methylglucose transport in rat epitrochlearis muscles to a level approximately six-fold above basal." | 3.68 | Stimulation of glucose transport in skeletal muscle by hypoxia. ( Cartee, GD; Douen, AG; Holloszy, JO; Klip, A; Ramlal, T, 1991) |
| "This study characterized in rhesus monkeys the effects of selected adenosine agonists on ventilation during normal atmospheric conditions and during conditions of hypercapnia, hypoxia and hyperoxia." | 3.68 | Effects of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys. ( Howell, LL, 1993) |
| "To test the hypothesis that the rate of left ventricular relaxation can be dissociated from left ventricular stiffness, indexes of stiffness and relaxation were evaluated during mild hypoxia and hypoxia with isoproterenol or caffeine in isovolumically beating, isolated rat heart preparations." | 3.67 | Separation of rate of left ventricular relaxation from chamber stiffness in rats. ( Iizuka, M; Momomura, S; Serizawa, T; Sugimoto, T, 1988) |
| "The efficacy of low and high dose caffeine on idiopathic bradycardia and hypoxaemia was tested in premature infants." | 3.67 | [Effectiveness of low- and high-dose caffeine on idiopathic bradycardia and hypoxemia in premature infants]. ( Bucher, HU; Duc, G; Fallenstein, F; Mieth, D, 1985) |
| " The purpose of this project was to determine whether a moderate dosage of caffeine, a common ventilatory stimulant, could augment resting ventilatory responsiveness, exercise ventilation (V E), end-tidal O2 partial pressure (PetO2), and arterial oxyhemoglobin saturation (HbSaO2) in athletes with EIH." | 2.73 | Caffeine stimulates ventilation in athletes with exercise-induced hypoxemia. ( Chapman, RF; Stager, JM, 2008) |
| " However, varying oxygen environments, such as Hx or neonatal IH, may alter and modify pharmacodynamic actions of caffeine and may even override the benefits caffeine." | 1.62 | Pharmacodynamic Effects of Standard versus High Caffeine Doses in the Developing Brain of Neonatal Rats Exposed to Intermittent Hypoxia. ( Ahmad, T; Aranda, JV; Beharry, KD; Cai, CL; Hand, I; Soontarapornchai, K, 2021) |
| "A stroke-like event follows seizures which may be responsible for the postictal state and a contributing factor to the development of seizure-induced brain abnormalities and behavioral dysfunction associated with epilepsy." | 1.51 | Caffeine Exacerbates Postictal Hypoxia. ( Gom, RC; Phillips, TJ; Teskey, GC; Wolff, MD, 2019) |
| "Caffeine has been shown to enhance the speed of recovery from general anesthesia in murine models, though data in human patients is lacking." | 1.48 | Effects of caffeine administration on sedation and respiratory parameters in patients recovering from anesthesia. ( Schroeder, DR; Sprung, J; Warner, MA; Warner, NS; Weingarten, TN, 2018) |
| "The pregnancy was complicated by maternal gestational diabetes mellitus and pre-eclampsia." | 1.46 | A Newborn Infant With Oxygen Desaturation During Sleep. ( Daftary, A; Deschamp, A, 2017) |
| "Caffeine was administered in drinking water (1 mg/ml)." | 1.38 | Chronic caffeine intake in adult rat inhibits carotid body sensitization produced by chronic sustained hypoxia but maintains intact chemoreflex output. ( Conde, SV; Gonzalez, C; Monteiro, EC; Obeso, A; Ribeiro, MJ; Rigual, R, 2012) |
| "Caffeine is a widely used psychostimulant freely crossing the placental barrier." | 1.35 | Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar hypoxia in newborn rats and adenosine A2A and GABA A receptor mRNA transcription. ( Guénin, S; Larnicol, N; Perrin, Y; Picard, N, 2008) |
| "Caffeine was dissolved in normal saline, so it was used as a control." | 1.35 | Embryonic caffeine exposure induces adverse effects in adulthood. ( Busovsky-McNeal, M; Ghatpande, S; Kalinowski, A; Rivkees, SA; Russell, KS; Wendler, CC, 2009) |
| "Thus anoxia has multiple effects on [Ca2+]i homeostasis in sensory neurons involving internal stores, mitochondrial buffering, and Ca2+ pumps." | 1.35 | Effects of anoxia and aglycemia on cytosolic calcium regulation in rat sensory neurons. ( Buckler, KJ; Henrich, M, 2008) |
| "IPA treated with thapsigargin (1 microM) in Ca2+-free solution to deplete Ca2+ stores showed sustained constriction upon re-exposure to Ca2+ and an increase in the rate of Mn2+ influx, suggesting capacitative Ca2+ entry." | 1.31 | Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat. ( Aaronson, PI; Hague, D; Robertson, TP; Ward, JP, 2000) |
| " In comparison to SEA, ALT resulted in a significant decrease in a caffeine half-life (t1/2, 4." | 1.29 | Effects of altitude (4300 m) on the pharmacokinetics of caffeine and cardio-green in humans. ( Brunhart, AE; Cymerman, A; Durkot, MJ; Eddington, ND; Fulco, CS; Hoyt, RW; Kamimori, GH; Lugo, S, 1995) |
| "Reversible effects of brief periods of anoxia (replacing 95% O2-5% CO2 with 95% N2-5% CO2 for 2-4 min) were studied in CA1 neurons in hippocampal slices (from Sprague-Dawley rats), kept in an interface-type chamber at 33." | 1.28 | Hypoxic changes in hippocampal neurons. ( Krnjevic, K; Leblond, J, 1989) |
| "The effect of DEPE was unchanged by anoxia." | 1.24 | Factors affecting the production of chromosome aberrations by chemicals. ( KIHLMAN, BA, 1956) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (25.00) | 18.7374 |
| 1990's | 26 (19.12) | 18.2507 |
| 2000's | 33 (24.26) | 29.6817 |
| 2010's | 29 (21.32) | 24.3611 |
| 2020's | 14 (10.29) | 2.80 |
| Authors | Studies |
|---|---|
| Jankeviciute, S | 1 |
| Svirskiene, N | 1 |
| Svirskis, G | 1 |
| Borutaite, V | 1 |
| Seppä-Moilanen, M | 1 |
| Andersson, S | 1 |
| Kirjavainen, T | 1 |
| Yang, L | 1 |
| Yu, X | 1 |
| Zhang, Y | 1 |
| Liu, N | 1 |
| Li, D | 1 |
| Xue, X | 1 |
| Fu, J | 1 |
| Trumbower, RD | 1 |
| Barth, S | 1 |
| Tuthill, C | 1 |
| Slocum, C | 1 |
| Shan, G | 1 |
| Zafonte, R | 1 |
| Mitchell, GS | 1 |
| Ikeda-Murakami, K | 1 |
| Ikeda, T | 1 |
| Watanabe, M | 2 |
| Tani, N | 1 |
| Ishikawa, T | 1 |
| Oliphant, EA | 2 |
| McKinlay, CJ | 1 |
| McNamara, D | 1 |
| Cavadino, A | 1 |
| Alsweiler, JM | 2 |
| Shah, AS | 1 |
| Leu, RM | 1 |
| Shah, SP | 1 |
| Martinez, F | 1 |
| Kasi, AS | 1 |
| Sabir, H | 1 |
| Maes, E | 1 |
| Zweyer, M | 1 |
| Schleehuber, Y | 1 |
| Imam, FB | 1 |
| Silverman, J | 1 |
| White, Y | 1 |
| Pang, R | 1 |
| Pasca, AM | 1 |
| Robertson, NJ | 1 |
| Maltepe, E | 1 |
| Bernis, ME | 1 |
| Phillips, TJ | 1 |
| Gom, RC | 1 |
| Wolff, MD | 1 |
| Teskey, GC | 1 |
| Gwon, LW | 1 |
| Park, SG | 1 |
| Lin, C | 1 |
| Lee, BJ | 1 |
| Nam, SY | 1 |
| McKinlay, CJD | 1 |
| McNamara, DG | 1 |
| Davis, PG | 1 |
| Conlon, S | 1 |
| Di Fiore, JM | 2 |
| Martin, RJ | 2 |
| Soontarapornchai, K | 1 |
| Cai, CL | 1 |
| Ahmad, T | 1 |
| Aranda, JV | 2 |
| Hand, I | 1 |
| Beharry, KD | 1 |
| Chen, JC | 1 |
| Hwang, JH | 1 |
| Dobson, NR | 2 |
| Rhein, LM | 2 |
| Darnall, RA | 2 |
| Corwin, MJ | 2 |
| Heeren, TC | 2 |
| Eichenwald, E | 1 |
| James, LP | 1 |
| McEntire, BL | 2 |
| Hunt, CE | 2 |
| Warner, NS | 1 |
| Warner, MA | 1 |
| Schroeder, DR | 1 |
| Sprung, J | 1 |
| Weingarten, TN | 1 |
| Maugeri, G | 1 |
| D'Amico, AG | 1 |
| Rasà, DM | 1 |
| Saccone, S | 1 |
| Federico, C | 1 |
| Magro, G | 1 |
| Cavallaro, S | 1 |
| D'Agata, V | 1 |
| van der Heijden, ME | 1 |
| Zoghbi, HY | 1 |
| Cao, T | 1 |
| Ma, T | 1 |
| Xu, Y | 1 |
| Tian, Y | 1 |
| Cai, Q | 1 |
| Li, B | 1 |
| Li, H | 1 |
| Poets, CF | 3 |
| Kubasov, IV | 1 |
| Nechaeva, MV | 1 |
| Alekseeva, TA | 1 |
| Sacramento, JF | 1 |
| Gonzalez, C | 4 |
| Gonzalez-Martin, MC | 1 |
| Conde, SV | 4 |
| Bairam, A | 7 |
| Uppari, N | 1 |
| Mubayed, S | 1 |
| Joseph, V | 5 |
| Gauda, E | 1 |
| MacFarlane, P | 1 |
| Adler, D | 1 |
| Fixler, D | 1 |
| Scheinowitz, M | 1 |
| Shainberg, A | 1 |
| Katz, A | 1 |
| Smirmaul, BP | 1 |
| de Moraes, AC | 1 |
| Angius, L | 1 |
| Marcora, SM | 1 |
| Wang, J | 1 |
| Hogan, JO | 1 |
| Kim, D | 1 |
| Deschamp, A | 1 |
| Daftary, A | 1 |
| Peoples, GE | 1 |
| McLennan, PL | 1 |
| Uppari, NP | 1 |
| Montandon, G | 2 |
| Kinkead, R | 2 |
| Li, XQ | 1 |
| Zheng, YM | 1 |
| Rathore, R | 1 |
| Ma, J | 1 |
| Takeshima, H | 1 |
| Wang, YX | 1 |
| Picard, N | 1 |
| Guénin, S | 1 |
| Larnicol, N | 1 |
| Perrin, Y | 1 |
| Sitkovsky, MV | 1 |
| Kjaergaard, J | 1 |
| Lukashev, D | 2 |
| Ohta, A | 2 |
| Kanatous, SB | 1 |
| Mammen, PP | 1 |
| Rosenberg, PB | 1 |
| Martin, CM | 1 |
| White, MD | 1 |
| Dimaio, JM | 1 |
| Huang, G | 1 |
| Muallem, S | 1 |
| Garry, DJ | 1 |
| Lajeunesse, Y | 1 |
| Wendler, CC | 2 |
| Busovsky-McNeal, M | 1 |
| Ghatpande, S | 1 |
| Kalinowski, A | 1 |
| Russell, KS | 1 |
| Rivkees, SA | 2 |
| Hatfield, S | 1 |
| Belikoff, B | 1 |
| Sitkovsky, M | 1 |
| Behringer, EJ | 1 |
| Leite, LD | 1 |
| Buchholz, NE | 1 |
| Keeney, MG | 1 |
| Pearce, WJ | 1 |
| Vanterpool, CK | 1 |
| Wilson, SM | 1 |
| Buchholz, JN | 1 |
| Julien, CA | 2 |
| BROWNE, RC | 1 |
| Mathew, OP | 1 |
| Henderson-Smart, DJ | 1 |
| De Paoli, AG | 1 |
| Burtscher, M | 1 |
| Mairer, K | 1 |
| Wille, M | 1 |
| Broessner, G | 1 |
| Foran, M | 1 |
| Strickland, F | 1 |
| Perkins, K | 1 |
| Smith, JA | 1 |
| Buscariollo, DL | 1 |
| Breuer, GA | 1 |
| Momoi, N | 1 |
| Tinney, JP | 1 |
| Keller, BB | 1 |
| Tobita, K | 1 |
| Sun, H | 1 |
| Xia, Y | 1 |
| Paudel, O | 1 |
| Yang, XR | 1 |
| Sham, JS | 2 |
| Ribeiro, MJ | 1 |
| Obeso, A | 3 |
| Rigual, R | 2 |
| Monteiro, EC | 2 |
| Dahan, D | 1 |
| Ducret, T | 1 |
| Quignard, JF | 1 |
| Marthan, R | 3 |
| Savineau, JP | 3 |
| Estève, E | 1 |
| Thorne, GD | 1 |
| Paul, RJ | 1 |
| Terada, S | 1 |
| Muraoka, I | 1 |
| Tabata, I | 1 |
| Renton, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Caffeine for Late Preterm Infants: A Double Blind Randomized Controlled Trial[NCT06026163] | Phase 2/Phase 3 | 134 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| Intermittent Hypoxia and Caffeine in Infants Born Preterm (ICAF)[NCT03321734] | Phase 2 | 170 participants (Actual) | Interventional | 2019-01-18 | Completed | ||
| Pilot Study of Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm[NCT01875159] | Phase 3 | 98 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU[NCT05451953] | 110 participants (Anticipated) | Interventional | 2022-07-21 | Recruiting | |||
| Effect of Rebreathing-induced Hypoxia on the Response to an Oral Glucose Tolerance Test[NCT05422430] | 30 participants (Anticipated) | Interventional | 2021-10-21 | Recruiting | |||
| [NCT01066728] | Phase 2/Phase 3 | 87 participants (Actual) | Interventional | 2001-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of episodes of Intermittent hypoxia per hour of pulse oximeter recording less than 90% oxygen saturation (NCT01875159)
Timeframe: 35, 36, 37, 38 weeks postmenstrual age
| Intervention | Events per hour (Mean) | |||
|---|---|---|---|---|
| Week 35 | Week 36 | Week 37 | Week 38 | |
| Active Comparator: no Caffeine | 8.4 | 8.2 | 5.2 | 4.7 |
| Caffeine | 3.6 | 3.8 | 4.3 | 4.2 |
Number of seconds of Intermittent hypoxia per hour of pulse oximeter recording less than 90% oxygen saturation (NCT01875159)
Timeframe: 35, 36, 37, 38 weeks postmenstrual age
| Intervention | seconds per hour (Mean) | |||
|---|---|---|---|---|
| Week 35 | Week 36 | Week 37 | Week 38 | |
| Active Comparator: no Caffeine | 106.3 | 100.1 | 66.8 | 66.0 |
| Caffeine | 50.9 | 49.5 | 58.8 | 69.3 |
10 reviews available for caffeine and Hypoxia
| Article | Year |
|---|---|
An Overview on the Respiratory Stimulant Effects of Caffeine and Progesterone on Response to Hypoxia and Apnea Frequency in Developing Rats.
Topics: Age Factors; Animals; Animals, Newborn; Apnea; Caffeine; Heart Rate; Hypoxia; Progesterone; Rats; Re | 2015 |
Cardiorespiratory events in preterm infants: interventions and consequences.
Topics: Animals; Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Continuous Positive Airway | 2016 |
Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia.
Topics: Adenosine; Animals; Caffeine; CD8-Positive T-Lymphocytes; Humans; Hypoxia; Hypoxia-Inducible Factor | 2008 |
The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells.
Topics: Acute Lung Injury; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Disease Models, | 2009 |
Apnea of prematurity: pathogenesis and management strategies.
Topics: Apnea; Arrhythmias, Cardiac; Brain Stem; Caffeine; Central Nervous System Stimulants; Continuous Pos | 2011 |
Prophylactic methylxanthine for prevention of apnoea in preterm infants.
Topics: Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Humans; Hypoxia; Infant, Newborn; I | 2010 |
Lung-function tests in neonates and infants with chronic lung disease: tidal breathing and respiratory control.
Topics: Adult; Animals; Caffeine; Central Nervous System Stimulants; Chemoreceptor Cells; Chronic Disease; F | 2006 |
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; | 1984 |
Contracture and the calcium paradox.
Topics: 2,4-Dinitrophenol; Aging; Animals; Caffeine; Calcium; Dimethyl Sulfoxide; Dinitrophenols; Freeze Fra | 1985 |
Control of insulin secretion by catecholamines, stress, and the sympathetic nervous system.
Topics: Animals; Caffeine; Catecholamines; Cyclic AMP; Diazoxide; Epinephrine; Glucose; Hypothermia; Hypoxia | 1973 |
9 trials available for caffeine and Hypoxia
| Article | Year |
|---|---|
Caffeine Enhances Intermittent Hypoxia-Induced Gains in Walking Function for People with Chronic Spinal Cord Injury.
Topics: Caffeine; Humans; Hypoxia; Oxygen; Spinal Cord Injuries; Walking | 2022 |
Caffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial.
Topics: Adult; Caffeine; Citrates; Double-Blind Method; Female; Humans; Hypoxia; Infant; Infant, Newborn; In | 2023 |
(Rad 8)Caffeine prophylaxis to improve intermittent hypoxaemia in infants born late preterm: a randomised controlled dosage trial (Latte Dosage Trial).
Topics: Apnea; Caffeine; Female; Humans; Hypoxia; Infant; Infant, Newborn; Infant, Premature; New Zealand; P | 2020 |
Effects of caffeine on intermittent hypoxia in infants born prematurely: a randomized clinical trial.
Topics: Caffeine; Central Nervous System Stimulants; Female; Gestational Age; Humans; Hypoxia; Infant, Newbo | 2014 |
Effects of caffeine on intermittent hypoxia in infants born prematurely: a randomized clinical trial.
Topics: Caffeine; Central Nervous System Stimulants; Female; Gestational Age; Humans; Hypoxia; Infant, Newbo | 2014 |
Effects of caffeine on intermittent hypoxia in infants born prematurely: a randomized clinical trial.
Topics: Caffeine; Central Nervous System Stimulants; Female; Gestational Age; Humans; Hypoxia; Infant, Newbo | 2014 |
Effects of caffeine on intermittent hypoxia in infants born prematurely: a randomized clinical trial.
Topics: Caffeine; Central Nervous System Stimulants; Female; Gestational Age; Humans; Hypoxia; Infant, Newbo | 2014 |
Effects of caffeine on neuromuscular fatigue and performance during high-intensity cycling exercise in moderate hypoxia.
Topics: Adult; Athletic Performance; Caffeine; Central Nervous System Stimulants; Exercise; Humans; Hypoxia; | 2017 |
Caffeine stimulates ventilation in athletes with exercise-induced hypoxemia.
Topics: Adult; Athletic Performance; Caffeine; Central Nervous System Stimulants; Exercise Test; Humans; Hyp | 2008 |
Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants.
Topics: Apnea; Birth Weight; Bradycardia; Caffeine; Doxapram; Drug Resistance; Gestational Age; Humans; Hypo | 1999 |
Effect of caffeine on ventilatory responses to hypercapnia, hypoxia, and exercise in humans.
Topics: Administration, Oral; Adult; Caffeine; Chemoreceptor Cells; Double-Blind Method; Exercise; Humans; H | 1990 |
Does caffeine prevent hypoxaemic episodes in premature infants? A randomized controlled trial.
Topics: Blood Gas Monitoring, Transcutaneous; Bradycardia; Caffeine; Citrates; Clinical Trials as Topic; Dou | 1988 |
117 other studies available for caffeine and Hypoxia
| Article | Year |
|---|---|
Effects of Metformin on Spontaneous Ca
Topics: Animals; Caffeine; Calcium Signaling; Chromans; Cyclosporine; Electron Transport Complex I; Female; | 2021 |
Caffeine is a respiratory stimulant without effect on sleep in the short-term in late-preterm infants.
Topics: Apnea; Caffeine; Carbon Dioxide; Central Nervous System Stimulants; Humans; Hypoxia; Infant; Infant, | 2022 |
Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage.
Topics: Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Humans; Hypoxia; Hypoxia-Ischemia, Brai | 2022 |
Central nervous system stimulants promote nerve cell death under continuous hypoxia.
Topics: Brain Edema; Caffeine; Cell Death; Cell Hypoxia; Central Nervous System Stimulants; Humans; Hypoxia; | 2022 |
Images: Caffeine therapy for central sleep apnea, hypoxemia, and hypoventilation in a term neonate.
Topics: Caffeine; Humans; Hypoventilation; Hypoxia; Infant; Sleep Apnea, Central; Sleep Apnea, Obstructive | 2023 |
Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial.
Topics: Allopurinol; Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Brain Injuries; Caffeine; Clemas | 2023 |
Caffeine Exacerbates Postictal Hypoxia.
Topics: Adenosine; Animals; CA1 Region, Hippocampal; Caffeine; Dose-Response Relationship, Drug; Hypoxia; Ki | 2019 |
The effects of caffeine and bisphenol A singularly or in combination on cultured mouse embryos and yolk sac placenta.
Topics: Animals; Apoptosis; Benzhydryl Compounds; Caffeine; Embryo, Mammalian; Embryonic Development; Female | 2020 |
When to start and stop caffeine and why respiratory status matters.
Topics: Apnea; Caffeine; Central Nervous System Stimulants; Citrates; Humans; Hypoxia; Infant; Infant, Newbo | 2020 |
Are we over-treating hypoxic spells in preterm infants?
Topics: Apnea; Caffeine; Humans; Hypoxia; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Dis | 2021 |
Pharmacodynamic Effects of Standard versus High Caffeine Doses in the Developing Brain of Neonatal Rats Exposed to Intermittent Hypoxia.
Topics: Animals; Animals, Newborn; Apoptosis; Biomarkers; Blood Gas Analysis; Brain; Caffeine; Cerebral Cort | 2021 |
Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats.
Topics: Animals; Apoptosis; Autophagy; Brain Neoplasms; Caffeine; Cell Line, Tumor; Endoplasmic Reticulum St | 2022 |
Caffeine decreases intermittent hypoxia in preterm infants nearing term-equivalent age.
Topics: Adult; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Citrates; Drug Administrat | 2017 |
Effects of caffeine administration on sedation and respiratory parameters in patients recovering from anesthesia.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Caffeine; Central Nervous System Stimu | 2018 |
Caffeine Effect on HIFs/VEGF Pathway in Human Glioblastoma Cells Exposed to Hypoxia.
Topics: Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Caffeine; Cell Line, Tumor; Cel | 2018 |
Loss of
Topics: Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Caffeine; Cell | 2018 |
Caffeine Treatment Promotes Differentiation and Maturation of Hypoxic Oligodendrocytes via Counterbalancing Adenosine 1 Adenosine Receptor-Induced Calcium Overload.
Topics: Adenosine; Animals; Caffeine; Calcium; Cell Differentiation; Cells, Cultured; China; Homeostasis; Hy | 2019 |
[Effect of acute hypoxia on the mechanical and electrical properties of the isolated skeletal muscles in the last third of chick embryogenesis].
Topics: Action Potentials; Animals; Caffeine; Chick Embryo; Chickens; Electric Stimulation; Embryonic Develo | 2014 |
Adenosine Receptor Blockade by Caffeine Inhibits Carotid Sinus Nerve Chemosensory Activity in Chronic Intermittent Hypoxic Animals.
Topics: Animals; Caffeine; Carotid Body; Carotid Sinus; Chronic Disease; Hypoxia; Purinergic P1 Receptor Ant | 2015 |
Weak electromagnetic fields alter Ca(2+) handling and protect against hypoxia-mediated damage in primary newborn rat myotube cultures.
Topics: Animals; Caffeine; Calcium; Calcium Signaling; Creatine Kinase; Electromagnetic Fields; Hypoxia; Ind | 2016 |
Voltage- and receptor-mediated activation of a non-selective cation channel in rat carotid body glomus cells.
Topics: Action Potentials; Angiotensin II; Anilides; Animals; Animals, Newborn; Caffeine; Calcium; Calcium C | 2017 |
A Newborn Infant With Oxygen Desaturation During Sleep.
Topics: Apgar Score; Caffeine; Central Nervous System Stimulants; Diabetes, Gestational; Female; Gestational | 2017 |
Dietary fish oil delays hypoxic skeletal muscle fatigue and enhances caffeine-stimulated contractile recovery in the rat in vivo hindlimb.
Topics: Animals; Caffeine; Diet; Dietary Fats; Docosahexaenoic Acids; Fatty Acids; Fatty Acids, Omega-3; Fat | 2017 |
Respiratory responses to progesterone and allopregnanolone following chronic caffeine treatment in newborn female rats.
Topics: Analysis of Variance; Anesthetics; Animals; Animals, Newborn; Apnea; Caffeine; Carbon Dioxide; Centr | 2017 |
Neonatal caffeine induces sex-specific developmental plasticity of the hypoxic respiratory chemoreflex in adult rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Animals, Newborn; Caffeine; Carotid Bo | 2008 |
Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells.
Topics: Animals; Caffeine; Calcium; Calcium Signaling; Female; Hypoxia; Membrane Potentials; Mice; Mice, Kno | 2009 |
Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar hypoxia in newborn rats and adenosine A2A and GABA A receptor mRNA transcription.
Topics: Adaptation, Physiological; Animals; Animals, Newborn; Body Temperature; Caffeine; Cell Count; Female | 2008 |
Hypoxia reprograms calcium signaling and regulates myoglobin expression.
Topics: Adaptation, Physiological; Animals; Caffeine; Calcineurin; Calcium Channels, L-Type; Calcium Signali | 2009 |
Enhancement of the breathing frequency response to hypoxia by neonatal caffeine treatment in adult male rats: the role of testosterone.
Topics: Age Factors; Animals; Animals, Newborn; Apnea; Caffeine; Central Nervous System Stimulants; Hypoxia; | 2009 |
Embryonic caffeine exposure induces adverse effects in adulthood.
Topics: Animals; Caffeine; Embryo, Mammalian; Female; Growth; Hypoxia; Maternal Exposure; Maternal-Fetal Exc | 2009 |
Maturation and long-term hypoxia alters Ca2+-induced Ca2+ release in sheep cerebrovascular sympathetic neurons.
Topics: Age Factors; Aging; Animals; Caffeine; Calcium; Calcium Signaling; Cerebral Arteries; Cyclic ADP-Rib | 2009 |
Caffeine reduces apnea frequency and enhances ventilatory long-term facilitation in rat pups raised in chronic intermittent hypoxia.
Topics: Animals; Animals, Newborn; Apnea; Caffeine; Central Nervous System Stimulants; Female; Humans; Hypox | 2010 |
Amphetamine and caffeine citrate in anoxaemia.
Topics: Amphetamine; Amphetamines; Caffeine; Citrates; Hypoxia; Oxygen; Respiratory System; Respiratory Trac | 1946 |
Risk factors for high-altitude headache in mountaineers.
Topics: Adult; Alcohol Drinking; Altitude; Altitude Sickness; Caffeine; Central Nervous System Stimulants; E | 2011 |
Alteration of carotid body chemoreflexes after neonatal intermittent hypoxia and caffeine treatment in rat pups.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Apnea; Body Temperature; Body Weight; | 2011 |
Excessive intraoperative bleeding with chronic energy drink consumption.
Topics: Acrocephalosyndactylia; Adolescent; Blood Loss, Surgical; Caffeine; Eleutherococcus; Energy Drinks; | 2012 |
Caffeine acts via A1 adenosine receptors to disrupt embryonic cardiac function.
Topics: Air; Animals; Caffeine; Gene Expression Regulation, Developmental; Heart; Heart Rate; Hypoxia; Mice; | 2011 |
Maternal hypoxia and caffeine exposure depress fetal cardiovascular function during primary organogenesis.
Topics: Animals; Caffeine; Female; Fetal Heart; Heart Rate, Fetal; Hemodynamics; Hypoxia; Male; Mice; Organo | 2012 |
Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity.
Topics: Animals; Anoctamin-1; Caffeine; Calcium; Chloride Channels; Hypoxia; In Vitro Techniques; Male; Myoc | 2012 |
Chronic caffeine intake in adult rat inhibits carotid body sensitization produced by chronic sustained hypoxia but maintains intact chemoreflex output.
Topics: Acclimatization; Adenosine; Animals; Caffeine; Carotid Body; Carotid Sinus; Chemoreceptor Cells; Dop | 2012 |
Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.
Topics: Animals; Caffeine; Calcium Channel Agonists; Calcium Signaling; Cell Hypoxia; Cells, Cultured; Dantr | 2012 |
Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats.
Topics: Animals; Caffeine; Carotid Body; Catecholamines; Chronic Disease; Hypoxia; Rats; Rats, Wistar; Recep | 2012 |
Effects of organ culture on arterial gene expression and hypoxic relaxation: role of the ryanodine receptor.
Topics: Animals; Arteries; Base Sequence; Caffeine; Calcium; DNA, Complementary; Gene Expression; Gene Expre | 2003 |
Changes in [Ca2+]i induced by several glucose transport-enhancing stimuli in rat epitrochlearis muscle.
Topics: Aminacrine; Animals; Biological Transport; Caffeine; Calcium; Dantrolene; Fura-2; Glucose; Hypoxia; | 2003 |
Hypoxia induces p53 through a pathway distinct from most DNA-damaging and stress-inducing agents.
Topics: Antineoplastic Agents; Caffeine; Cell Nucleus; Central Nervous System Stimulants; DNA; DNA Damage; H | 2003 |
[Action of strychnine and caffeine on the resistance of the cerebral cortex of the rat to experimental anoxia].
Topics: Animals; Caffeine; Cerebral Cortex; Hypoxia; Nervous System Physiological Phenomena; Rats; Strychnin | 1954 |
[Effect of various drugs on electrocardiographic tracing in hypoxia].
Topics: Bromides; Caffeine; Electrocardiography; Humans; Hypoxia | 1954 |
Factors affecting the production of chromosome aberrations by chemicals.
Topics: Caffeine; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Dinitrophenols; Hydrogen-Ion Co | 1956 |
Factors affecting the production of chromosome aberrations by chemicals.
Topics: Caffeine; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Dinitrophenols; Hydrogen-Ion Co | 1956 |
Factors affecting the production of chromosome aberrations by chemicals.
Topics: Caffeine; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Dinitrophenols; Hydrogen-Ion Co | 1956 |
Factors affecting the production of chromosome aberrations by chemicals.
Topics: Caffeine; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Dinitrophenols; Hydrogen-Ion Co | 1956 |
Effect of caffeine on the metabolism of normal and hypoxic heart muscle.
Topics: Caffeine; Congenital Abnormalities; Humans; Hypoxia; Myocardium | 1958 |
AN ATTEMPT AT NORMALIZATION OF THE PROCESS OF EXCITATION IN THE BRAIN CORTEX OF RATS DURING LOW PRESSURE HYPOXIA.
Topics: Amphetamine; Amphetamines; Brain; Bromine; Caffeine; Cerebral Cortex; Conditioning, Classical; Hypox | 1963 |
CALCIUM IN RELATION TO THE ACTIONS OF OUABAIN AND ADRENALINE ON THE HEART.
Topics: Animals; Caffeine; Calcium; Calcium Chloride; Calcium, Dietary; Cardiac Glycosides; Epinephrine; Hea | 1964 |
THE CONVERSION OF PHOSPHORYLASE B TO PHOSPHORYLASE A IN BRAIN.
Topics: Amphetamine; Amphetamines; Brain; Caffeine; Catecholamines; Cocaine; Enzyme Inhibitors; Histocytoche | 1965 |
The effect of caffeine on peripheral vascular resistance in isolated perfused guinea pig hind limbs.
Topics: Adenosine; Animals; Caffeine; Dose-Response Relationship, Drug; Female; Flavins; Guinea Pigs; Hindli | 2003 |
Calcium homeostasis in rat cardiomyocytes during chronic hypoxia: a time course study.
Topics: Adrenergic beta-Agonists; Animals; Caffeine; Calcium; Calcium-Transporting ATPases; Cells, Cultured; | 2003 |
Sildenafil alters calcium signaling and vascular tone in pulmonary arteries from chronically hypoxic rats.
Topics: Angiotensin II; Animals; Caffeine; Calcium; Calcium Signaling; Chronic Disease; Disease Models, Anim | 2004 |
Positive inotropism in mammalian skeletal muscle in vitro during and after fatigue.
Topics: Animals; Bucladesine; Caffeine; Canada; Cyclic AMP; Drug Evaluation, Preclinical; Electric Stimulati | 2004 |
Allosteric models for multimeric proteins: oxygen-linked effector binding in hemocyanin.
Topics: Allosteric Regulation; Animals; Binding Sites; Caffeine; Calorimetry; Hemocyanins; Hypoxia; Models, | 2005 |
Intermittent hypoxia protects cardiomyocytes against ischemia-reperfusion injury-induced alterations in Ca2+ homeostasis and contraction via the sarcoplasmic reticulum and Na+/Ca2+ exchange mechanisms.
Topics: Altitude; Animals; Caffeine; Calcium; Calcium-Transporting ATPases; Homeostasis; Hypoxia; Male; Musc | 2006 |
Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling.
Topics: Animals; Autocrine Communication; Boron Compounds; Brain; Brain-Derived Neurotrophic Factor; Butacla | 2006 |
Caffeine in the milk prevents respiratory disorders caused by in utero caffeine exposure in rats.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Female; Hypoxia; Milk; Pregnancy; Prenatal Exp | 2006 |
Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors.
Topics: Adenosine; Animals; Caffeine; Carotid Body; Catecholamines; Central Nervous System Stimulants; Chemo | 2006 |
Chronic intermittent hypoxia alters Ca2+ handling in rat cardiomyocytes by augmented Na+/Ca2+ exchange and ryanodine receptor activities in ischemia-reperfusion.
Topics: Animals; Body Weight; Caffeine; Calcium; Electrophysiology; Gene Expression Regulation; Heart; Heart | 2007 |
Effects of anoxia and aglycemia on cytosolic calcium regulation in rat sensory neurons.
Topics: Analysis of Variance; Animals; Caffeine; Calcium; Calcium Signaling; Capsaicin; Carbonyl Cyanide p-T | 2008 |
[Oxygen deficiency and its pathogenesis in barbiturate poisoning].
Topics: Adult; Ascorbic Acid; Barbiturates; Caffeine; Female; Humans; Hypoxia; Male; Middle Aged; Oxygen Con | 1966 |
Effects of anoxia on cerebral blood flow in the rat brain: evidence for a role of adenosine in autoregulation.
Topics: Adenosine; Animals; Brain; Caffeine; Cerebrovascular Circulation; Dipyridamole; Homeostasis; Hypoxia | 1984 |
Possible alterations in brain monoamine metabolism during hypoxia-induced tachypnea in cats.
Topics: Aminophylline; Animals; Biogenic Amines; Brain; Caffeine; Carbidopa; Cats; Dihydroxyphenylalanine; D | 1980 |
Load-insensitive relaxation caused by hypoxia in mammalian cardiac muscle.
Topics: Animals; Caffeine; Cats; Hypoxia; Muscle Contraction; Muscle Relaxation; Myocardial Contraction; Myo | 1981 |
Effects of altitude (4300 m) on the pharmacokinetics of caffeine and cardio-green in humans.
Topics: Administration, Oral; Adult; Altitude; Caffeine; Follow-Up Studies; Humans; Hypoxia; Indocyanine Gre | 1995 |
Effects of chronic hypoxia on the pharmacokinetics of caffeine and cardio-green in micro swine.
Topics: Altitude; Animals; Caffeine; Chronic Disease; Disease Models, Animal; Female; Hypoxia; Indocyanine G | 1995 |
Facilitation of beta-adrenoceptor-mediated slow channel responses by hypoxia in guinea pig ventricular myocardium.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Caffeine; Catecholamines; Electrophysiology; Guine | 1993 |
Role of adenosine in the hypoxic ventilatory response of the newborn piglet.
Topics: Adenosine; Animals; Animals, Newborn; Caffeine; Cerebrospinal Fluid; Citrates; Dipyridamole; Drug Co | 1994 |
Mechanisms of CBF augmentation during hypoxia in cats: probable participation of prostacyclin, nitric oxide and adenosine.
Topics: Adenosine; Animals; Arginine; Caffeine; Cats; Cerebrovascular Circulation; Epoprostenol; Hypoxia; In | 1994 |
O2 occlusion and cyanide induced immediate relaxation and contraction of murine skeletal muscle.
Topics: Animals; Caffeine; Cyanides; Electric Stimulation; Glyburide; Hypoxia; In Vitro Techniques; Mice; Mi | 1993 |
Acute hypoxia increases cytosolic calcium in cultured pulmonary arterial myocytes.
Topics: Acute Disease; Animals; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cells, Cu | 1993 |
Effects of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Carbon Dioxide; Female; Hypercapnia | 1993 |
Effect of soleus unweighting on stimulation of insulin-independent glucose transport activity.
Topics: Animals; Biological Transport, Active; Caffeine; Deoxyglucose; Glucose; Glucose Transporter Type 4; | 1993 |
Developmental differences and regional similarities in the responses of rat cardiac skinned muscles to acidosis, inorganic phosphate and caffeine.
Topics: Acidosis; Animals; Atrial Function; Caffeine; Calcium; Heart Atria; Heart Ventricles; Hypoxia; In Vi | 1996 |
Caffeine and ischemia--effects on immediate early genes and adenosine receptors.
Topics: Animals; Brain Ischemia; Caffeine; Genes, Immediate-Early; Hypoxia; Proto-Oncogene Proteins c-fos; R | 1996 |
Effects of hypoxia/reoxygenation on aortic vasoconstrictor responsiveness.
Topics: Animals; Aorta, Thoracic; Caffeine; Catalase; Endothelium, Vascular; Enzyme Inhibitors; Free Radical | 1996 |
Carotid chemosensory response to caffeine in developing cats.
Topics: Animals; Animals, Suckling; Blood Pressure; Caffeine; Carotid Body; Cats; Hyperoxia; Hypoxia; Synapt | 1996 |
Protection against cellular damage in the perfused rat heart by lowered pH.
Topics: Amiloride; Animals; Caffeine; Calcium; Creatine Kinase; Hydrogen-Ion Concentration; Hypoxia; In Vitr | 1997 |
The energetics of the quiescent heart muscle: high potassium cardioplegic solution and the influence of calcium and hypoxia on the rat heart.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Cardioplegic Solutions; Ener | 1997 |
Hypoxia enhances agonist-induced pulmonary arterial contraction by increasing calcium sequestration.
Topics: Animals; Caffeine; Calcium; Hypoxia; In Vitro Techniques; Indoles; Muscle Contraction; Muscle, Smoot | 1997 |
The effect of theophylline on apnoea and hypoxaemic episodes in the premature neonate during the 1st 3 days after birth.
Topics: Apnea; Blood Pressure; Bradycardia; Bronchodilator Agents; Caffeine; Female; Gestational Age; Humans | 1998 |
Epileptogenic action of caffeine during anoxia in the neonatal rat hippocampus.
Topics: Action Potentials; Animals; Caffeine; Epilepsy; Hypoxia; Male; Neurons; Rats; Rats, Wistar; Receptor | 1999 |
Protection against cellular damage in the rat heart by hyperosmotic solutions.
Topics: Animals; Caffeine; Calcium; Creatine Kinase; Heart; Heart Injuries; Hypertonic Solutions; Hypoxia; O | 1999 |
Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Chelating Agents; Diltiazem; | 2000 |
Hypoxic constriction of porcine distal pulmonary arteries: endothelium and endothelin dependence.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchial Arteries; Caffeine; Calcium; Cell Surviv | 2001 |
Effect of chronic hypoxia on agonist-induced tone and calcium signaling in rat pulmonary artery.
Topics: Adenosine Triphosphate; Angiotensin II; Animals; Caffeine; Calcium; Calcium Signaling; Chronic Disea | 2001 |
Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle.
Topics: Animals; Caffeine; Calcium; Extracellular Space; Hypoxia; In Vitro Techniques; Intracellular Membran | 2001 |
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor.
Topics: Adenosine; Animals; Anxiety; Autoradiography; Behavior, Animal; Caffeine; Hippocampus; Hyperalgesia; | 2001 |
Ryanodine receptor-mediated [Ca(2+)](i) release in glomus cells is independent of natural stimuli and does not participate in the chemosensory responses of the rat carotid body.
Topics: Action Potentials; Animals; Caffeine; Calcium; Calcium Signaling; Carotid Body; Cell Membrane; Cell | 2001 |
Intracellular and extracellular calcium utilization during hypoxic vasoconstriction of cyclostome aortas.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans.
Topics: Acute Disease; Adult; Altitude; Caffeine; Cytochrome P-450 Enzyme System; Female; Humans; Hydrocorti | 2002 |
Determinants of hypoxic contracture in isolated heart muscle preparations.
Topics: Animals; Anura; Caffeine; Calcium; Cats; Hydrogen-Ion Concentration; Hypoxia; In Vitro Techniques; I | 1979 |
Effect of some drugs on cerebral energy state during and after hypoxia and complete or incomplete ischemia.
Topics: Animals; Benzhydryl Compounds; Brain; Caffeine; Dogs; Energy Metabolism; Female; Hypoxia; Ischemic A | 1979 |
[Effect of caffeine on human body resistance to hypoxia (author's transl)].
Topics: Adaptation, Physiological; Adult; Altitude; Caffeine; Hemodynamics; Humans; Hypoxia; Male; Middle Ag | 1977 |
The xanthine treatment of apnea of prematurity.
Topics: Aminophylline; Apnea; Bradycardia; Caffeine; Humans; Hypoxia; Infant, Newborn; Infant, Premature, Di | 1975 |
[Effect of caffeine and fasting on the resistance of rats against aerogenous hypoxia].
Topics: Anaerobiosis; Animals; Caffeine; Energy Metabolism; Fasting; Hypoxia; Male; Rats | 1976 |
Recovery of anoxic-reoxygenated cardiomyocytes from severe Ca2+ overload.
Topics: Animals; Caffeine; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Hypoxia; Male; Myocardial | 1992 |
Effects of adenosinergic drugs on hypoxia-induced electrophysiological changes in rat hippocampal slices.
Topics: Adenosine; Animals; Caffeine; Dizocilpine Maleate; Electrophysiology; Hippocampus; Hypoxia; In Vitro | 1992 |
Intracellular milieu changes associated with hypoxia impair sarcoplasmic reticulum Ca2+ transport in cardiac muscle.
Topics: Adenosine Diphosphate; Animals; Caffeine; Calcium; Heart; Hypoxia; In Vitro Techniques; Kinetics; My | 1991 |
Stimulation of glucose transport in skeletal muscle by hypoxia.
Topics: 3-O-Methylglucose; Adenosine Triphosphate; Animals; Biological Transport, Active; Caffeine; Glucose; | 1991 |
Effects of hypoxia, acidosis, and simulated ischemia on repriming of caffeine contracture in rat myocardium.
Topics: Acidosis; Animals; Caffeine; Coronary Disease; Heart; Hypoxia; Male; Myocardial Contraction; Rats; R | 1990 |
Hypoxic changes in hippocampal neurons.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Apamin; Caffeine; Calcium; Egtazic | 1989 |
Measurement of urinary caffeine metabolites reflecting the "in vivo" xanthine oxidase activity in premature infants with RDS and in hypoxic states of children.
Topics: Biomarkers; Caffeine; Humans; Hypoxia; Infant, Newborn; Infant, Premature; Respiratory Distress Synd | 1989 |
Separation of rate of left ventricular relaxation from chamber stiffness in rats.
Topics: Animals; Blood Pressure; Caffeine; Heart Ventricles; Hypoxia; Isoproterenol; Male; Myocardial Contra | 1988 |
Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Body Fluids; Caffeine; Calcium; Hypoxia; Intrace | 1988 |
[Effectiveness of low- and high-dose caffeine on idiopathic bradycardia and hypoxemia in premature infants].
Topics: Bradycardia; Caffeine; Citrates; Dose-Response Relationship, Drug; Drug Combinations; Humans; Hypoxi | 1985 |
Correlations between electrical and pharmacological observations during anoxia in the rabbit, in normal and assisted respiration.
Topics: Amphetamine; Brain; Caffeine; Electroencephalography; Ethylamines; Hypoxia; Meclofenoxate; Methylphe | 1971 |
The effect of caffeine and altitude hypoxia on some changes of tissue metabolism in the rat.
Topics: Altitude; Animals; Blood Glucose; Brain; Caffeine; Glucose; Glycogen; Hypoxia; Lactates; Liver; Male | 1968 |
[Resuscitation of the newborn].
Topics: Acidosis, Respiratory; Apnea; Bicarbonates; Caffeine; Catheterization; Cyanosis; Equipment and Suppl | 1969 |
The demonstration of energy dependence of the isoproterenol-induced transcellular Ca2+ current in isolated perfused guinea pig hearts--an explanation for mechanical failure of ischemic myocardium.
Topics: Action Potentials; Animals; Biological Transport; Caffeine; Calcium; Cell Membrane; Cell Membrane Pe | 1974 |
[Changes in glucose, lactic acid and pyruvate blood levels of rats during normal and lowered barometric pressure after administration of glucose and caffeine].
Topics: Animals; Atmospheric Pressure; Blood Glucose; Caffeine; Carbohydrates; Glucose; Hypoxia; Lactates; P | 1972 |
The effect of caffeine on rats with various altitude hypoxia resistance.
Topics: Altitude; Animals; Caffeine; Hypoxia; Intubation, Gastrointestinal; Rats | 1972 |
[Prophylaxis and therapy of the mountain sickness, puna].
Topics: Altitude; Caffeine; Ergotamine; Headache; Humans; Hypoxia; Nausea; Oxygen Inhalation Therapy; Physic | 1971 |
[Pangamic acid in migraine].
Topics: Barbiturates; Brain; Caffeine; Ergotamine; Humans; Hypoxia; Migraine Disorders; Oxygen Consumption; | 1966 |