caffeine has been researched along with Genetic Predisposition in 80 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our aim was to observe the induction of anxiety symptoms and panic attacks by a caffeine challenge test in panic disorder (PD) patients (DSM-IV) and their healthy first-degree relatives." | 9.13 | A caffeine challenge test in panic disorder patients, their healthy first-degree relatives, and healthy controls. ( de-Melo-Neto, VL; Freire, RC; King, AL; Lopes, FL; Mezzasalma, MA; Nardi, AE; Nascimento, I; Rassi, A; Soares-Filho, GL; Valença, AM; Veras, AB; Zin, WA, 2008) |
| "This review summarizes and highlights recent advances in current knowledge of the relationship between coffee and caffeine consumption and risk of coronary heart disease." | 8.84 | Coffee, caffeine, and coronary heart disease. ( Cornelis, MC; El-Sohemy, A, 2007) |
| "Some case-control studies have demonstrated that caffeine intake and high CYP1A2 activity increase risks of recurrent pregnancy loss (RPL) but the multifactorial effect is obscure." | 7.73 | Caffeine intake, CYP1A2 polymorphism and the risk of recurrent pregnancy loss. ( Kato, EH; Kishi, R; Minakami, H; Morikawa, M; Saijo, Y; Sata, F; Suzuki, K; Yamada, H, 2005) |
| "Our aim was to observe the induction of anxiety symptoms and panic attacks by a caffeine challenge test in panic disorder (PD) patients (DSM-IV) and their healthy first-degree relatives." | 5.13 | A caffeine challenge test in panic disorder patients, their healthy first-degree relatives, and healthy controls. ( de-Melo-Neto, VL; Freire, RC; King, AL; Lopes, FL; Mezzasalma, MA; Nardi, AE; Nascimento, I; Rassi, A; Soares-Filho, GL; Valença, AM; Veras, AB; Zin, WA, 2008) |
| "This review summarizes and highlights recent advances in current knowledge of the relationship between coffee and caffeine consumption and risk of coronary heart disease." | 4.84 | Coffee, caffeine, and coronary heart disease. ( Cornelis, MC; El-Sohemy, A, 2007) |
| "NAT2 acetylation status was determined by both single nucleotide polymorphisms (SNPs) and caffeine metabolic ratio (CMR), in a population-based study of 494 bladder cancer patients and 507 control subjects in Shanghai, China." | 3.83 | Differential association for N-acetyltransferase 2 genotype and phenotype with bladder cancer risk in Chinese population. ( Chan, KK; Chattopadhyay, K; Gao, YT; Nelson, HH; Quan, L; Wang, R; Xiang, YB; Yuan, JM; Zhang, W, 2016) |
| "Animal models have suggested that oral or topical administration of caffeine could inhibit ultraviolet-induced carcinogenesis via the ataxia telangiectasia and rad3 (ATR)-related apoptosis." | 3.83 | A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma. ( Cornelis, MC; De Vivo, I; Giovannucci, E; Han, J; Li, X; Liang, L; Song, F; Tang, JY, 2016) |
| "The aim of the present study was to evaluate the relative contribution of CYP1A2 isoforms (-3860 G/A, -2467T/delT and -163C/A) in control subjects and breast cancer patients to the metabolism of caffeine in human liver." | 3.81 | Breast Cancer Association with CYP1A2 Activity and Gene Polymorphisms--a Preliminary Case-control Study in Tunisia. ( Arij, M; Imene, A; Maurice, AJ; Saad, S; Sofia, P, 2015) |
| "Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC)." | 3.80 | Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study. ( Aleksandrova, K; Argüelles, M; Barricarte, A; Bech, BH; Boeing, H; Boutron-Ruault, MC; Braaten, T; Bueno-de-Mesquita, HB; Campa, D; Cauchi, S; Chirlaque, MD; Dik, VK; Dorronsoro, M; Engeset, D; Fagherazzi, G; Freisling, H; Froguel, P; Grioni, S; Gunter, MJ; Jenab, M; Jirström, K; Khaw, KT; Kühn, T; Licaj, I; Ljuslinder, I; Murphy, N; Nilsson, LM; Oikonomou, E; Olsen, A; Overvad, K; Palli, D; Panico, S; Peeters, PH; Peppa, E; Racine, A; Riboli, E; Romaguera-Bosch, D; Sánchez, MJ; Siersema, PD; Tjønneland, A; Travis, RC; Trichopoulou, A; Tumino, R; Uiterwaal, CS; Van Duijnhoven, FJ; Van Gils, CH; Van Oijen, MG; Vineis, P; Wallström, P; Wareham, N; Weiderpass, E; Yengo, L; Zamora-Ros, R, 2014) |
| "A web-based sample (n=43,799 including both members of 609 twin and 303 sibling pairs) completed assessments of number of lifetime gambling episodes, DSM-IV criteria for PG, alcohol, nicotine and caffeine intake, and nicotine dependence (ND) and DSM-III-R criteria for lifetime major depression (MD)." | 3.78 | Gambling, disordered gambling and their association with major depression and substance use: a web-based cohort and twin-sibling study. ( Blanco, C; Kendler, KS; Myers, J, 2012) |
| "Some case-control studies have demonstrated that caffeine intake and high CYP1A2 activity increase risks of recurrent pregnancy loss (RPL) but the multifactorial effect is obscure." | 3.73 | Caffeine intake, CYP1A2 polymorphism and the risk of recurrent pregnancy loss. ( Kato, EH; Kishi, R; Minakami, H; Morikawa, M; Saijo, Y; Sata, F; Suzuki, K; Yamada, H, 2005) |
| "The NAT acetylator status was determined by measuring urinary caffeine metabolites in 134 nonpregnant women with a history of preeclampsia and in 109 control women with uncomplicated pregnancy." | 3.73 | N-acetyl-transferase phenotype and risk for preeclampsia. ( Peters, WH; Raijmakers, MT; Roes, EM; Steegers, EA; Steegers-Theunissen, RP; te Morsche, RH; Zusterzeel, PL, 2005) |
| "The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex- and age-matched normal controls." | 3.70 | Common fragile site expression and genetic predisposition to breast cancer. ( Ceçener, G; Duman, H; Egeli, U; Kizil, A; Taşdelen, I; Tunca, B, 1998) |
| "DNA-based diagnosis for malignant hyperthermia (MH) is an attractive proposition, because it could replace the invasive and morbid caffeine-halothane/in vitro contracture tests of skeletal muscle biopsy tissue." | 2.50 | DNA testing for malignant hyperthermia: the reality and the dream. ( Stowell, KM, 2014) |
| "The problem of malignant hyperthermia may become worse in the near future due to changes in the population brought about by immigration." | 2.44 | [Anesthesia in malignant hyperthermia]. ( Ortiz Gómez, JR, 2008) |
| "Analyses stratified by genetic predisposition, comorbidities, and sex hormones were performed." | 1.72 | Sex-specific association between coffee consumption and incident chronic kidney disease: a population-based analysis of 359,906 participants from the UK Biobank. ( Chen, W; Fu, P; Hu, Y; Li, C; Qu, Y; Song, H; Tang, L; Yang, H; Yang, L; Zeng, X; Zeng, Y, 2022) |
| "Caffeine intake has been inversely associated with Parkinson's disease (PD) risk." | 1.48 | Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk. ( Ascherio, A; Betensky, RA; Gao, X; Hannan, MT; Hughes, KC; Kim, IY; McCullough, ML; O'Reilly, ÉJ; Schwarzschild, MA, 2018) |
| "We identified 43 malignant hyperthermia families carrying one of the six RYR1 variants." | 1.46 | Assessing the pathogenicity of RYR1 variants in malignant hyperthermia. ( Allen, PD; Bilmen, JG; Booms, P; Daly, C; Hopkins, PM; Merritt, A; Miller, DM; Shaw, MA; Steele, DS; Stowell, KM, 2017) |
| "Malignant hyperthermia is a life-threatening condition caused by autosomal dominant mutations in the ryanodine receptor type 1 gene." | 1.37 | Analysis of human cultured myotubes responses mediated by ryanodine receptor 1. ( Hamada, H; Kawamoto, M; Kobayashi, M; Migita, T; Mukaida, K; Yuge, O, 2011) |
| "Caffeine intake has been associated with a decreased risk of Parkinson's disease (PD) in men but the effect in women is less clear, and appears to be modified by use of post-menopausal estrogens." | 1.36 | Polymorphisms of caffeine metabolism and estrogen receptor genes and risk of Parkinson's disease in men and women. ( Ascherio, A; Gao, X; Palacios, N; Schwarzschild, M; Simon, K; Weisskopf, M, 2010) |
| "Malignant hyperthermia is a pharmacogenetic skeletal muscle disorder of intracellular calcium (Ca2+) homeostasis with an autosomal dominant inheritance." | 1.35 | Effects of propofol on calcium homeostasis in human skeletal muscle. ( Hamada, H; Kawamoto, M; Kobayashi, M; Migita, T; Mukaida, K; Nishino, I; Yuge, O, 2009) |
| "Roberts syndrome is an autosomal recessive disorder characterised primarily by symmetric reduction of all limbs and growth retardation." | 1.32 | Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. ( Ascoli, C; Mariani, T; Montagna, C; Musio, A; Ried, T; Vezzoni, P; Zambroni, D, 2004) |
| "The caffeine ratio was statistically significantly higher in men compared to women, in smoking men and women compared to non-smoking persons of the same gender and in women not taking oral contraceptives compared with women on oral contraceptives." | 1.31 | The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors. ( Brix, TH; Brøsen, K; Kyvik, KO; Rasmussen, BB, 2002) |
| "The diagnostic outcomes of tests for malignant hyperthermia susceptibility were compared between two laboratories by using muscle tissue from the same patients." | 1.31 | Between-center variability of results of the in vitro contracture test for malignant hyperthermia susceptibility. ( Bendixen, D; Islander, G; Ording, H; Ranklev-Twetman, E, 2000) |
| "Central core disease (CCD) and nemaline myopathy (NM) are congenital myopathies for which differential diagnosis is often based on the presence either of cores or rods." | 1.31 | An autosomal dominant congenital myopathy with cores and rods is associated with a neomutation in the RYR1 gene encoding the skeletal muscle ryanodine receptor. ( Fardeau, M; Lerale, J; Lunardi, J; MacLennan, DH; Monnier, N; Nivoche, Y; Qi, D; Romero, NB, 2000) |
| "Xenon 70% did not cause an increase in baseline tension of any MH-susceptible muscle specimen in contrast to halothane and caffeine." | 1.31 | Xenon does not induce contracture in human malignant hyperthermia muscle. ( Baur, CP; Froeba, G; Georgieff, M; Jurkat-Rott, K; Klingler, W; Lehmann-Horn, F; Marx, T; Schoch, E, 2000) |
| "The determination of susceptibility to malignant hyperthermia (MH) by genetic investigation is a controversial issue because of the genetic heterogeneity of this disorder." | 1.31 | Homozygous and heterozygous Arg614Cys mutations (1840C-->T) in the ryanodine receptor gene co-segregate with malignant hyperthermia susceptibility in a German family. ( Deutrich, C; Froster, UG; Olthoff, D; Rueffert, H; Thamm, B, 2001) |
| "Caffeine is an addictive psychoactive substance." | 1.30 | Caffeine intake, tolerance, and withdrawal in women: a population-based twin study. ( Kendler, KS; Prescott, CA, 1999) |
| "Malignant hyperthermia is a potentially fatal pharmacogenetic disorder triggered by volatile anesthetics (halothane, enflurane, isoflurane) and/or succinylcholine." | 1.28 | [Diagnosis of susceptibility for malignant hyperthermia using in-vitro muscle contraction testing in Switzerland]. ( Censier, K; Drewe, J; Frei, F; Rothenbühler, JM; Seeberger, MD; Urwyler, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.25) | 18.7374 |
| 1990's | 11 (13.75) | 18.2507 |
| 2000's | 31 (38.75) | 29.6817 |
| 2010's | 34 (42.50) | 24.3611 |
| 2020's | 3 (3.75) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, L | 1 |
| Yang, L | 1 |
| Chen, W | 1 |
| Li, C | 1 |
| Zeng, Y | 1 |
| Yang, H | 1 |
| Hu, Y | 1 |
| Qu, Y | 1 |
| Song, H | 1 |
| Zeng, X | 1 |
| Fu, P | 1 |
| Drogou, C | 1 |
| Erblang, M | 1 |
| Metlaine, A | 1 |
| Berot, S | 1 |
| Derbois, C | 1 |
| Olaso, R | 1 |
| Boland, A | 1 |
| Deleuze, JF | 1 |
| Thomas, C | 1 |
| Léger, D | 1 |
| Chennaoui, M | 1 |
| Sauvet, F | 1 |
| Gomez-Merino, D | 1 |
| Wren, LM | 1 |
| DeKeyser, JM | 1 |
| Barefield, DY | 1 |
| Hawkins, NA | 1 |
| McNally, EM | 1 |
| Kearney, JA | 1 |
| Wasserstrom, JA | 1 |
| George, AL | 1 |
| Findley, AS | 1 |
| Richards, AL | 1 |
| Petrini, C | 1 |
| Alazizi, A | 1 |
| Doman, E | 1 |
| Shanku, AG | 1 |
| Davis, GO | 1 |
| Hauff, N | 1 |
| Sorokin, Y | 1 |
| Wen, X | 1 |
| Pique-Regi, R | 1 |
| Luca, F | 1 |
| Simon, DK | 1 |
| Wu, C | 1 |
| Tilley, BC | 1 |
| Lohmann, K | 1 |
| Klein, C | 1 |
| Payami, H | 2 |
| Wills, AM | 1 |
| Aminoff, MJ | 1 |
| Bainbridge, J | 1 |
| Dewey, R | 1 |
| Hauser, RA | 1 |
| Schaake, S | 1 |
| Schneider, JS | 1 |
| Sharma, S | 1 |
| Singer, C | 1 |
| Tanner, CM | 2 |
| Truong, D | 1 |
| Wei, P | 1 |
| Wong, PS | 1 |
| Yang, T | 1 |
| Merritt, A | 1 |
| Booms, P | 2 |
| Shaw, MA | 3 |
| Miller, DM | 1 |
| Daly, C | 1 |
| Bilmen, JG | 1 |
| Stowell, KM | 2 |
| Allen, PD | 2 |
| Steele, DS | 2 |
| Hopkins, PM | 4 |
| Michelucci, A | 1 |
| Paolini, C | 1 |
| Boncompagni, S | 1 |
| Canato, M | 1 |
| Reggiani, C | 1 |
| Protasi, F | 1 |
| Kim, IY | 1 |
| O'Reilly, ÉJ | 1 |
| Hughes, KC | 1 |
| Gao, X | 2 |
| Schwarzschild, MA | 1 |
| McCullough, ML | 1 |
| Hannan, MT | 1 |
| Betensky, RA | 1 |
| Ascherio, A | 2 |
| Kondo, T | 1 |
| Yasuda, T | 1 |
| Mukaida, K | 3 |
| Otsuki, S | 1 |
| Kanzaki, R | 1 |
| Miyoshi, H | 1 |
| Hamada, H | 3 |
| Nishino, I | 2 |
| Kawamoto, M | 3 |
| Cornelis, MC | 3 |
| Munafo, MR | 1 |
| Orlov, D | 1 |
| Keith, J | 1 |
| Rosen, D | 1 |
| Croul, S | 1 |
| Kraeva, N | 1 |
| Riazi, S | 1 |
| Le Guen, M | 1 |
| Houissa, H | 1 |
| Langeron, O | 1 |
| Dik, VK | 1 |
| Bueno-de-Mesquita, HB | 1 |
| Van Oijen, MG | 1 |
| Siersema, PD | 1 |
| Uiterwaal, CS | 1 |
| Van Gils, CH | 1 |
| Van Duijnhoven, FJ | 1 |
| Cauchi, S | 1 |
| Yengo, L | 1 |
| Froguel, P | 1 |
| Overvad, K | 1 |
| Bech, BH | 1 |
| Tjønneland, A | 1 |
| Olsen, A | 1 |
| Boutron-Ruault, MC | 1 |
| Racine, A | 1 |
| Fagherazzi, G | 1 |
| Kühn, T | 1 |
| Campa, D | 1 |
| Boeing, H | 1 |
| Aleksandrova, K | 1 |
| Trichopoulou, A | 1 |
| Peppa, E | 1 |
| Oikonomou, E | 1 |
| Palli, D | 1 |
| Grioni, S | 1 |
| Vineis, P | 1 |
| Tumino, R | 1 |
| Panico, S | 1 |
| Peeters, PH | 1 |
| Weiderpass, E | 1 |
| Engeset, D | 1 |
| Braaten, T | 1 |
| Dorronsoro, M | 1 |
| Chirlaque, MD | 1 |
| Sánchez, MJ | 1 |
| Barricarte, A | 1 |
| Zamora-Ros, R | 1 |
| Argüelles, M | 1 |
| Jirström, K | 1 |
| Wallström, P | 1 |
| Nilsson, LM | 1 |
| Ljuslinder, I | 1 |
| Travis, RC | 1 |
| Khaw, KT | 1 |
| Wareham, N | 1 |
| Freisling, H | 1 |
| Licaj, I | 1 |
| Jenab, M | 1 |
| Gunter, MJ | 1 |
| Murphy, N | 1 |
| Romaguera-Bosch, D | 1 |
| Riboli, E | 1 |
| Kiyohara, C | 2 |
| Washio, M | 1 |
| Horiuchi, T | 1 |
| Asami, T | 1 |
| Ide, S | 1 |
| Atsumi, T | 1 |
| Kobashi, G | 1 |
| Takahashi, H | 1 |
| Tada, Y | 1 |
| Yamada-Fowler, N | 1 |
| Fredrikson, M | 1 |
| Söderkvist, P | 1 |
| Palatini, P | 1 |
| Benetti, E | 1 |
| Mos, L | 1 |
| Garavelli, G | 1 |
| Mazzer, A | 1 |
| Cozzio, S | 1 |
| Fania, C | 1 |
| Casiglia, E | 1 |
| Imene, A | 1 |
| Maurice, AJ | 1 |
| Arij, M | 1 |
| Sofia, P | 1 |
| Saad, S | 1 |
| Kumar, PM | 1 |
| Paing, SS | 1 |
| Li, H | 1 |
| Pavanni, R | 1 |
| Yuen, Y | 1 |
| Zhao, Y | 1 |
| Tan, EK | 1 |
| Johannsen, S | 1 |
| Treves, S | 2 |
| Müller, CR | 1 |
| Mögele, S | 1 |
| Schneiderbanger, D | 1 |
| Roewer, N | 1 |
| Schuster, F | 1 |
| Quan, L | 1 |
| Chattopadhyay, K | 1 |
| Nelson, HH | 1 |
| Chan, KK | 1 |
| Xiang, YB | 1 |
| Zhang, W | 2 |
| Wang, R | 1 |
| Gao, YT | 1 |
| Yuan, JM | 1 |
| Li, X | 1 |
| Liang, L | 1 |
| Song, F | 1 |
| De Vivo, I | 1 |
| Giovannucci, E | 1 |
| Tang, JY | 1 |
| Han, J | 1 |
| Delamarre, A | 1 |
| Meissner, WG | 1 |
| Nunes, RA | 1 |
| Mazzotti, DR | 1 |
| Hirotsu, C | 1 |
| Andersen, ML | 1 |
| Tufik, S | 1 |
| Bittencourt, L | 1 |
| Kendler, KS | 3 |
| Schmitt, E | 1 |
| Aggen, SH | 1 |
| Prescott, CA | 2 |
| Facheris, MF | 1 |
| Schneider, NK | 1 |
| Lesnick, TG | 1 |
| de Andrade, M | 1 |
| Cunningham, JM | 1 |
| Rocca, WA | 1 |
| Maraganore, DM | 1 |
| Kadlubar, S | 1 |
| Anderson, JP | 1 |
| Sweeney, C | 1 |
| Gross, MD | 1 |
| Lang, NP | 1 |
| Kadlubar, FF | 1 |
| Anderson, KE | 1 |
| Migita, T | 2 |
| Kobayashi, M | 2 |
| Yuge, O | 2 |
| Carpenter, D | 2 |
| Robinson, RL | 2 |
| Quinnell, RJ | 1 |
| Ringrose, C | 2 |
| Hogg, M | 1 |
| Casson, F | 1 |
| Iles, DE | 1 |
| Halsall, PJ | 2 |
| Leo, V | 1 |
| Morris, A | 1 |
| Palacios, N | 1 |
| Weisskopf, M | 1 |
| Simon, K | 1 |
| Schwarzschild, M | 1 |
| Yang, A | 1 |
| Childs, E | 2 |
| Palmer, AA | 1 |
| de Wit, H | 2 |
| Mellick, GD | 1 |
| Ross, OA | 1 |
| Popat, RA | 1 |
| Van Den Eeden, SK | 1 |
| Kamel, F | 1 |
| Umbach, DM | 1 |
| Marder, K | 1 |
| Mayeux, R | 1 |
| Ritz, B | 1 |
| Ross, GW | 1 |
| Petrovitch, H | 1 |
| Topol, B | 1 |
| McGuire, V | 1 |
| Costello, S | 1 |
| Manthripragada, AD | 1 |
| Southwick, A | 1 |
| Myers, RM | 1 |
| Nelson, LM | 1 |
| Hill-Burns, EM | 1 |
| Hamza, TH | 1 |
| Zabetian, CP | 1 |
| Factor, SA | 1 |
| Blanco, C | 1 |
| Myers, J | 1 |
| Amin, N | 1 |
| Byrne, E | 1 |
| Johnson, J | 1 |
| Chenevix-Trench, G | 2 |
| Walter, S | 1 |
| Nolte, IM | 1 |
| Vink, JM | 1 |
| Rawal, R | 1 |
| Mangino, M | 1 |
| Teumer, A | 1 |
| Keers, JC | 1 |
| Verwoert, G | 1 |
| Baumeister, S | 1 |
| Biffar, R | 1 |
| Petersmann, A | 1 |
| Dahmen, N | 1 |
| Doering, A | 1 |
| Isaacs, A | 1 |
| Broer, L | 1 |
| Wray, NR | 1 |
| Montgomery, GW | 1 |
| Levy, D | 1 |
| Psaty, BM | 1 |
| Gudnason, V | 1 |
| Chakravarti, A | 1 |
| Sulem, P | 1 |
| Gudbjartsson, DF | 1 |
| Kiemeney, LA | 1 |
| Thorsteinsdottir, U | 1 |
| Stefansson, K | 1 |
| van Rooij, FJ | 1 |
| Aulchenko, YS | 1 |
| Hottenga, JJ | 1 |
| Rivadeneira, FR | 1 |
| Hofman, A | 1 |
| Uitterlinden, AG | 1 |
| Hammond, CJ | 1 |
| Shin, SY | 1 |
| Ikram, A | 1 |
| Witteman, JC | 1 |
| Janssens, AC | 1 |
| Snieder, H | 1 |
| Tiemeier, H | 1 |
| Wolfenbuttel, BH | 1 |
| Oostra, BA | 1 |
| Heath, AC | 1 |
| Wichmann, E | 1 |
| Spector, TD | 1 |
| Grabe, HJ | 1 |
| Boomsma, DI | 1 |
| Martin, NG | 1 |
| van Duijn, CM | 1 |
| Domschke, K | 1 |
| Gajewska, A | 1 |
| Winter, B | 1 |
| Herrmann, MJ | 1 |
| Warrings, B | 1 |
| Mühlberger, A | 1 |
| Wosnitza, K | 1 |
| Glotzbach, E | 1 |
| Conzelmann, A | 1 |
| Dlugos, A | 1 |
| Fobker, M | 1 |
| Jacob, C | 1 |
| Arolt, V | 1 |
| Reif, A | 1 |
| Pauli, P | 1 |
| Zwanzger, P | 1 |
| Deckert, J | 2 |
| Eltit, JM | 1 |
| Bannister, RA | 1 |
| Moua, O | 1 |
| Altamirano, F | 1 |
| Pessah, IN | 1 |
| Molinski, TF | 1 |
| López, JR | 1 |
| Beam, KG | 1 |
| Johnson, JK | 1 |
| Waddell, N | 1 |
| Gao, J | 1 |
| Nalls, MA | 1 |
| Shi, M | 1 |
| Joubert, BR | 1 |
| Hernandez, DG | 1 |
| Huang, X | 1 |
| Hollenbeck, A | 1 |
| Singleton, AB | 1 |
| Chen, H | 1 |
| Miyake, Y | 1 |
| Tanaka, K | 1 |
| Fukushima, W | 1 |
| Sasaki, S | 1 |
| Tsuboi, Y | 1 |
| Yamada, T | 1 |
| Oeda, T | 1 |
| Shimada, H | 1 |
| Kawamura, N | 1 |
| Sakae, N | 1 |
| Fukuyama, H | 1 |
| Hirota, Y | 1 |
| Nagai, M | 1 |
| Rasmussen, BB | 1 |
| Brix, TH | 1 |
| Kyvik, KO | 1 |
| Brøsen, K | 1 |
| Goodman, MT | 1 |
| Tung, KH | 1 |
| McDuffie, K | 1 |
| Wilkens, LR | 1 |
| Donlon, TA | 1 |
| Wehner, M | 1 |
| Rueffert, H | 2 |
| Koenig, F | 1 |
| Olthoff, D | 2 |
| Ginz, HF | 1 |
| Girard, T | 2 |
| Censier, K | 3 |
| Urwyler, A | 3 |
| Musio, A | 1 |
| Mariani, T | 1 |
| Montagna, C | 1 |
| Zambroni, D | 1 |
| Ascoli, C | 1 |
| Ried, T | 1 |
| Vezzoni, P | 1 |
| Sata, F | 1 |
| Yamada, H | 1 |
| Suzuki, K | 1 |
| Saijo, Y | 1 |
| Kato, EH | 1 |
| Morikawa, M | 1 |
| Minakami, H | 1 |
| Kishi, R | 1 |
| Logroscino, G | 1 |
| Zusterzeel, PL | 1 |
| te Morsche, RH | 1 |
| Raijmakers, MT | 1 |
| Roes, EM | 1 |
| Peters, WH | 1 |
| Steegers-Theunissen, RP | 1 |
| Steegers, EA | 1 |
| Natarajan, TG | 1 |
| Ganesan, N | 1 |
| Carter-Nolan, P | 1 |
| Tucker, CA | 1 |
| Shields, PG | 1 |
| Adams-Campbell, LL | 1 |
| Kannankeril, PJ | 1 |
| Mitchell, BM | 1 |
| Goonasekera, SA | 1 |
| Chelu, MG | 1 |
| Sood, S | 1 |
| Kearney, DL | 1 |
| Danila, CI | 1 |
| De Biasi, M | 1 |
| Wehrens, XH | 1 |
| Pautler, RG | 1 |
| Roden, DM | 1 |
| Taffet, GE | 1 |
| Dirksen, RT | 1 |
| Anderson, ME | 1 |
| Hamilton, SL | 1 |
| Islander, G | 4 |
| Rydenfelt, K | 1 |
| Ranklev, E | 1 |
| Bodelsson, M | 1 |
| Campos, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Epidemiology of Sleep Disturbances Among the Adult Population of the Sao Paulo City[NCT00596713] | 1,100 participants (Actual) | Observational | 2007-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for caffeine and Genetic Predisposition
| Article | Year |
|---|---|
Mendelian Randomization Studies of Coffee and Caffeine Consumption.
Topics: Caffeine; Central Nervous System Stimulants; Coffee; Feeding Behavior; Genetic Predisposition to Dis | 2018 |
DNA testing for malignant hyperthermia: the reality and the dream.
Topics: Biopsy; Caffeine; Calcium Channels; Calcium Channels, L-Type; Computational Biology; Genetic Predisp | 2014 |
Epidemiology, environmental risk factors and genetics of Parkinson's disease.
Topics: Age Distribution; Age of Onset; alpha-Synuclein; Caffeine; Causality; Gene-Environment Interaction; | 2017 |
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
Topics: Antigens, Neoplasm; Apoptosis Regulatory Proteins; Caffeine; Cell Adhesion Molecules; Cell Line; Cof | 2012 |
The role of early life environmental risk factors in Parkinson disease: what is the evidence?
Topics: Age Factors; Animals; Caffeine; Coffee; Environmental Exposure; Genetic Predisposition to Disease; H | 2005 |
Coffee consumption and risk of type 2 diabetes and heart disease.
Topics: Caffeine; Coffee; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Genetic Predisposition to Dise | 2007 |
Coffee, caffeine, and coronary heart disease.
Topics: Beverages; Blood Pressure; Caffeine; Cholesterol; Coffee; Coronary Disease; Dose-Response Relationsh | 2007 |
[Anesthesia in malignant hyperthermia].
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Caffeine; Calcium Signaling; Child; Child, Prescho | 2008 |
Epidemiology and inheritance of malignant hyperthermia.
Topics: Adenosine Triphosphate; Caffeine; Creatine Kinase; Female; Genetic Predisposition to Disease; Haloth | 1979 |
4 trials available for caffeine and Genetic Predisposition
| Article | Year |
|---|---|
Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages.
Topics: Adult; Alcohol Drinking; Arylamine N-Acetyltransferase; Asian People; Beverages; Caffeine; Case-Cont | 2014 |
A caffeine challenge test in panic disorder patients, their healthy first-degree relatives, and healthy controls.
Topics: Adult; Arousal; Caffeine; Central Nervous System Stimulants; Citrates; Double-Blind Method; Female; | 2008 |
Developmental instability predicts individual variation in verbal memory skill after caffeine ingestion.
Topics: Abnormalities, Multiple; Adolescent; Adult; Biomarkers; Caffeine; Central Nervous System Stimulants; | 2000 |
Genotype-phenotype comparison of the Swiss malignant hyperthermia population.
Topics: Caffeine; DNA Mutational Analysis; Gene Frequency; Genetic Heterogeneity; Genetic Predisposition to | 2001 |
67 other studies available for caffeine and Genetic Predisposition
| Article | Year |
|---|---|
Sex-specific association between coffee consumption and incident chronic kidney disease: a population-based analysis of 359,906 participants from the UK Biobank.
Topics: Bayes Theorem; Biological Specimen Banks; Caffeine; Coffee; Female; Genetic Predisposition to Diseas | 2022 |
Relationship between genetic polymorphisms of cytokines and self-reported sleep complaints and habitual caffeine consumption.
Topics: Caffeine; Cross-Sectional Studies; Cytokines; Genetic Predisposition to Disease; Genotype; Humans; P | 2023 |
Sex and Gene Influence Arrhythmia Susceptibility in Murine Models of Calmodulinopathy.
Topics: Animals; Arrhythmias, Cardiac; Caffeine; Calmodulin; Disease Models, Animal; Epinephrine; Female; Ge | 2023 |
Interpreting Coronary Artery Disease Risk Through Gene-Environment Interactions in Gene Regulation.
Topics: Caffeine; Coronary Artery Disease; Endothelial Cells; Gene Expression Regulation; Gene-Environment I | 2019 |
Caffeine, creatine, GRIN2A and Parkinson's disease progression.
Topics: Aged; Caffeine; Creatine; Disease Progression; Female; Gene-Environment Interaction; Genetic Predisp | 2017 |
Assessing the pathogenicity of RYR1 variants in malignant hyperthermia.
Topics: Caffeine; Calcium; Cloning, Molecular; Family; Genetic Predisposition to Disease; Genetic Variation; | 2017 |
Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia.
Topics: Animals; Caffeine; Calcium-Binding Proteins; Calsequestrin; Electric Stimulation; Gene Expression Re | 2017 |
Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk.
Topics: Caffeine; Case-Control Studies; Cohort Studies; Cytochrome P-450 CYP1A2; Female; Gene Frequency; Gen | 2018 |
Genetic and functional analysis of the RYR1 mutation p.Thr84Met revealed a susceptibility to malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Child; Cresols; Genetic Predisposition to Disease; HEK293 Cells; Humans; | 2018 |
Analysis of histomorphology in malignant hyperthermia-susceptible patients.
Topics: Adult; Caffeine; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Halothane; | 2013 |
[Malignant hyperthermia: multifactorial events leading to a crisis].
Topics: Accidents, Traffic; Algorithms; Bicycling; Biopsy; Caffeine; Central Nervous System Stimulants; Gene | 2013 |
Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study.
Topics: Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Case-Control Studies; Coffee; Cohort Studies; | 2014 |
Caffeine interaction with glutamate receptor gene GRIN2A: Parkinson's disease in Swedish population.
Topics: Aged; Aged, 80 and over; Caffeine; Case-Control Studies; Female; Gene Frequency; Genetic Predisposit | 2014 |
Association of coffee consumption and CYP1A2 polymorphism with risk of impaired fasting glucose in hypertensive patients.
Topics: Adolescent; Adult; Blood Glucose; Caffeine; Coffee; Cytochrome P-450 CYP1A2; Female; Follow-Up Studi | 2015 |
Breast Cancer Association with CYP1A2 Activity and Gene Polymorphisms--a Preliminary Case-control Study in Tunisia.
Topics: Breast Neoplasms; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Female; Genetic Predispos | 2015 |
Differential effect of caffeine intake in subjects with genetic susceptibility to Parkinson's Disease.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Case-Control Studies; Drinking; Female; Gene Frequency; Ge | 2015 |
Functional characterization of the RYR1 mutation p.Arg4737Trp associated with susceptibility to malignant hyperthermia.
Topics: Anesthetics; Arginine; B-Lymphocytes; Caffeine; Cell Line, Transformed; Cresols; Family Health; Fema | 2016 |
Differential association for N-acetyltransferase 2 genotype and phenotype with bladder cancer risk in Chinese population.
Topics: Aged; Arylamine N-Acetyltransferase; Asian People; Caffeine; Carcinogens; Case-Control Studies; Chin | 2016 |
A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Caffeine; Carcinogenesis; Carcinoma, Basal Cell; Ep | 2016 |
The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Central Nervous System Stimulants; Female; Genetic Predisp | 2017 |
Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood.
Topics: Adolescent; Adult; Age Factors; Alcoholism; Caffeine; Central Nervous System Stimulants; Child; Dise | 2008 |
Coffee, caffeine-related genes, and Parkinson's disease: a case-control study.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Case-Control Studies; Coffee; Cytochrome P-450 CYP1A2; DNA | 2008 |
Phenotypic CYP2A6 variation and the risk of pancreatic cancer.
Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Caffeine; Carcinogens; Case-Control S | 2009 |
Effects of propofol on calcium homeostasis in human skeletal muscle.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Caffeine; Calcium; Child; Child, Preschool; Dose- | 2009 |
Genetic variation in RYR1 and malignant hyperthermia phenotypes.
Topics: Anesthetics, Inhalation; Caffeine; Creatine Kinase; DNA Mutational Analysis; DNA, Complementary; Fem | 2009 |
The role of CACNA1S in predisposition to malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Amino Acid Sequence; Caffeine; Calcium Channels; Calcium Channels, L-Type; | 2009 |
Polymorphisms of caffeine metabolism and estrogen receptor genes and risk of Parkinson's disease in men and women.
Topics: Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Estrogen Replacement Therapy; Female; Genet | 2010 |
More on ADORA.
Topics: Anxiety; Caffeine; Central Nervous System Stimulants; Coffee; Drinking Behavior; Feeding Behavior; G | 2010 |
Caffeine and Parkinson's disease: are we getting our fix on risk-modifying gene-environment interactions?
Topics: Caffeine; Cytochrome P-450 CYP1A2; Female; Genetic Predisposition to Disease; Humans; Male; Neuropro | 2011 |
Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease.
Topics: Aged; Caffeine; Case-Control Studies; Cohort Studies; Cytochrome P-450 CYP1A2; Female; Genetic Predi | 2011 |
Analysis of human cultured myotubes responses mediated by ryanodine receptor 1.
Topics: Adolescent; Adult; Aged; Caffeine; Calcium; Cells, Cultured; Child; Child, Preschool; Cresols; Dose- | 2011 |
An attempt to replicate interaction between coffee and CYP1A2 gene in connection to Parkinson's disease.
Topics: Caffeine; Cytochrome P-450 CYP1A2; Female; Genetic Predisposition to Disease; Humans; Male; Neuropro | 2011 |
Gambling, disordered gambling and their association with major depression and substance use: a web-based cohort and twin-sibling study.
Topics: Adult; Alcohol Drinking; Behavior, Addictive; Caffeine; Cohort Studies; Depressive Disorder, Major; | 2012 |
ADORA2A Gene variation, caffeine, and emotional processing: a multi-level interaction on startle reflex.
Topics: Adult; Anxiety; Caffeine; Double-Blind Method; Emotions; Female; Genetic Predisposition to Disease; | 2012 |
Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor.
Topics: Analysis of Variance; Anesthetics; Body Temperature; Caffeine; Calcium; Caveolin 1; DNA, Complementa | 2012 |
The application of nonsense-mediated mRNA decay inhibition to the identification of breast cancer susceptibility genes.
Topics: Base Sequence; Breast Neoplasms; Caffeine; Cell Line, Tumor; Family; Female; Gene Expression Profili | 2012 |
An exploratory analysis on gene-environment interactions for Parkinson disease.
Topics: Age of Onset; Aged; Caffeine; Female; Gene-Environment Interaction; Genetic Loci; Genetic Predisposi | 2012 |
Lack of association between BST1 polymorphisms and sporadic Parkinson's disease in a Japanese population.
Topics: ADP-ribosyl Cyclase; Age of Onset; Aged; Antigens, CD; Asian People; Caffeine; Case-Control Studies; | 2012 |
The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors.
Topics: Adolescent; Adult; Biotransformation; Caffeine; Central Nervous System Stimulants; Chromatography, H | 2002 |
Association of caffeine intake and CYP1A2 genotype with ovarian cancer.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Caffeine; Case-Control Studies; Confidence Intervals; Cy | 2003 |
Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala.
Topics: Adult; Aged; Caffeine; Calcium; Child; Child, Preschool; Cresols; Female; Genetic Predisposition to | 2003 |
Similar susceptibility to halothane, caffeine and ryanodine in vitro reflects pharmacogenetic variability of malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Biopsy; Caffeine; Central Nervo | 2004 |
Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes.
Topics: Abnormalities, Multiple; Aneuploidy; Caffeine; Cell Cycle; Cell Division; Cell Line; Centromere; Chr | 2004 |
Caffeine intake, CYP1A2 polymorphism and the risk of recurrent pregnancy loss.
Topics: Abortion, Habitual; Adult; Alleles; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Female; | 2005 |
N-acetyl-transferase phenotype and risk for preeclampsia.
Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Female; Genetic Predisposition to Disease; HELLP Syn | 2005 |
gamma-Radiation-induced chromosomal mutagen sensitivity is associated with breast cancer risk in African-American women: caffeine modulates the outcome of mutagen sensitivity assay.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Biomarkers, Tumor; Black or African American; Brea | 2006 |
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.
Topics: Animals; Caffeine; Cardiomyopathies; Catecholamines; Central Nervous System Stimulants; Epinephrine; | 2006 |
Male preponderance of patients testing positive for malignant hyperthermia susceptibility.
Topics: Caffeine; Family; Female; Genetic Predisposition to Disease; Halothane; Humans; Male; Malignant Hype | 2007 |
Genotype-phenotype correlation of paroxysmal nonkinesigenic dyskinesia.
Topics: Adolescent; Adult; Age of Onset; Caffeine; Child; Child, Preschool; Chorea; DNA Mutational Analysis; | 2007 |
Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety.
Topics: Adenosine; Adolescent; Adult; Anxiety Disorders; Brain; Brain Chemistry; Caffeine; DNA Mutational An | 2008 |
Expression of N-acetyltransferase (NAT) in cultured human uroepithelial cells.
Topics: Acetylation; Adult; Alleles; Amines; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Cells, Cul | 1994 |
Reduced Mg2+ inhibition of Ca2+ release in muscle fibers of pigs susceptible to malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Dantrolene; Genetic Predisposition to Disease; | 1997 |
Malignant hyperthermia susceptibility, an autosomal dominant disorder?
Topics: Adolescent; Adult; Caffeine; Calcium Channels; Child; Child, Preschool; Female; Genes, Dominant; Gen | 1997 |
The Israeli Diagnostic Center for Malignant Hyperthermia: 7-years' accumulated experience.
Topics: Academies and Institutes; Adult; Aged; Biopsy; Caffeine; Child; Electromyography; Female; Genetic Pr | 1997 |
Discordance between malignant hyperthermia susceptibility and RYR1 mutation C1840T in two Scandinavian MH families exhibiting this mutation.
Topics: Anesthesia; Caffeine; Denmark; Female; Genetic Predisposition to Disease; Halothane; Humans; Male; M | 1997 |
Caffeine intake, tolerance, and withdrawal in women: a population-based twin study.
Topics: Adult; Caffeine; Carbonated Beverages; Coffee; Diseases in Twins; Drug Overdose; Drug Tolerance; Fem | 1999 |
Common fragile site expression and genetic predisposition to breast cancer.
Topics: Aphidicolin; Breast Neoplasms; Caffeine; Chromosome Aberrations; Chromosome Fragile Sites; Chromosom | 1998 |
[Malignant hyperthermia: difficulty in diagnosing susceptibility in Spain].
Topics: Anesthetics, Inhalation; Caffeine; Europe; Genetic Predisposition to Disease; Halothane; Humans; Inf | 1999 |
The expression of fragile sites in lymphocytes of patients with rectum cancer and their first-degree relatives.
Topics: Adult; Aged; Aphidicolin; Bromodeoxyuridine; Caffeine; Case-Control Studies; Cells, Cultured; Chromo | 2000 |
The expression frequency of common fragile sites and genetic predisposition to colon cancer.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Alu Elements; Aphidicolin; Bromodeoxyuridine; Caffeine; Chi | 2000 |
Between-center variability of results of the in vitro contracture test for malignant hyperthermia susceptibility.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Biopsy; Caffeine; Female; Genetic Predisposition t | 2000 |
An autosomal dominant congenital myopathy with cores and rods is associated with a neomutation in the RYR1 gene encoding the skeletal muscle ryanodine receptor.
Topics: Amino Acid Substitution; Caffeine; Calcium; Cell Line; DNA Mutational Analysis; Female; France; Gene | 2000 |
Xenon does not induce contracture in human malignant hyperthermia muscle.
Topics: Anesthetics, Inhalation; Caffeine; Culture Techniques; Dose-Response Relationship, Drug; Drug Evalua | 2000 |
Homozygous and heterozygous Arg614Cys mutations (1840C-->T) in the ryanodine receptor gene co-segregate with malignant hyperthermia susceptibility in a German family.
Topics: Adult; Anesthetics, Inhalation; Caffeine; DNA Mutational Analysis; Female; Genetic Predisposition to | 2001 |
Evaluation of greyhound susceptibility to malignant hyperthermia using halothane-succinylcholine anesthesia and caffeine-halothane muscle contractures.
Topics: Anesthesia, Inhalation; Animals; Caffeine; Disease Susceptibility; Dog Diseases; Dogs; Genetic Predi | 1992 |
Are there interactions and relations between genetic and environmental factors predisposing to high blood pressure?
Topics: Alcohol Drinking; Caffeine; Educational Status; Exercise; Genes; Genetic Predisposition to Disease; | 1991 |
[Diagnosis of susceptibility for malignant hyperthermia using in-vitro muscle contraction testing in Switzerland].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; Caffeine; Child; Female; Genetic Predisposition | 1991 |