Page last updated: 2024-10-24

caffeine and Fatty Liver

caffeine has been researched along with Fatty Liver in 25 studies

Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.

Research Excerpts

ExcerptRelevanceReference
" In this study we analysed in the rat a model of fatty liver induced by administration of caffeine."7.68Lipid peroxidation in fatty liver induced by caffeine in rats. ( Biocca, ME; Canuto, RA; Dianzani, MU; Muzio, G, 1991)
"Severe NAFLD appeared with higher Kleiner scores."5.40Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring. ( Chen, L; Huang, H; Liu, Y; Liu, Z; Ping, J; Shen, L; Wang, H; Wang, L; Wu, Y; Zhang, L, 2014)
"The association of CC with nonalcoholic fatty liver disease (NAFLD) has not been established."5.38Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis. ( Calcagno, CJ; Harrison, SA; Jones, FJ; Molloy, JW; Torres, DM; Williams, CD, 2012)
"Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is the most common cause of primary liver disease."5.38Caffeine is protective in patients with non-alcoholic fatty liver disease. ( Birerdinc, A; Pawloski, L; Stepanova, M; Younossi, ZM, 2012)
"The treatment with caffeine in the rats fed the high-carbohydrate, high-fat diet decreased body fat and systolic blood pressure, improved glucose tolerance and insulin sensitivity, and attenuated cardiovascular and hepatic abnormalities, although the plasma lipid concentrations were further increased."5.38Caffeine attenuates metabolic syndrome in diet-induced obese rats. ( Brown, L; Kauter, K; Panchal, SK; Ward, LC; Wong, WY, 2012)
"The CBT was applied to 48 patients with NAFLD."5.37Non-invasive estimation of liver fibrosis in non-alcoholic fatty liver disease using the 13 C-caffeine breath test. ( Fung, C; George, J; Katelaris, PH; Ngu, MC; Park, GJ; Seow, F; Wiseman, E, 2011)
" Caffeine has anti-inflammation, antihepatic steatosis, and anti-insulin resistance effects."3.88Effects and mechanisms of caffeine to improve immunological and metabolic abnormalities in diet-induced obese rats. ( Hou, MC; Hsieh, YC; Huang, CC; Huang, SF; Lee, FY; Lee, KC; Lee, SD; Li, TH; Lin, HC; Lin, MW; Liu, CW; Su, YB; Tsai, CY; Tsai, HC; Yang, YY, 2018)
" In this study we analysed in the rat a model of fatty liver induced by administration of caffeine."3.68Lipid peroxidation in fatty liver induced by caffeine in rats. ( Biocca, ME; Canuto, RA; Dianzani, MU; Muzio, G, 1991)
"Obesity, non-alcoholic fatty liver and steatohepatitis as well as diabetes mellitus together also form a significant risk for HCC, due to the gradually increasing number of patients."2.46[Role of environmental factors in the etiology of hepatocellular carcinoma]. ( Tornai, I, 2010)
"Caffeine was not associated significantly with LSM at any dose."1.72Coffee Consumption Is Associated With Lower Liver Stiffness: A Nationally Representative Study. ( Jiang, ZG; Mehta, M; Niezen, S; Tapper, EB, 2022)
"Caffeine elimination was accelerated by microvesicular steatosis, whereas midazolam elimination was delayed in macrovesicular steatosis."1.72Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism. ( Albadry, M; Böttcher, M; Christ, B; Christ, M; Dahmen, U; Dirsch, O; Ehteshamzad, N; Höpfl, S; Klopfleisch, R; König, M; Laue, H; Lupp, A; Neumann, J; Radde, N; Schwen, LO, 2022)
"Severe NAFLD appeared with higher Kleiner scores."1.40Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring. ( Chen, L; Huang, H; Liu, Y; Liu, Z; Ping, J; Shen, L; Wang, H; Wang, L; Wu, Y; Zhang, L, 2014)
"The association of CC with nonalcoholic fatty liver disease (NAFLD) has not been established."1.38Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis. ( Calcagno, CJ; Harrison, SA; Jones, FJ; Molloy, JW; Torres, DM; Williams, CD, 2012)
"Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is the most common cause of primary liver disease."1.38Caffeine is protective in patients with non-alcoholic fatty liver disease. ( Birerdinc, A; Pawloski, L; Stepanova, M; Younossi, ZM, 2012)
"The treatment with caffeine in the rats fed the high-carbohydrate, high-fat diet decreased body fat and systolic blood pressure, improved glucose tolerance and insulin sensitivity, and attenuated cardiovascular and hepatic abnormalities, although the plasma lipid concentrations were further increased."1.38Caffeine attenuates metabolic syndrome in diet-induced obese rats. ( Brown, L; Kauter, K; Panchal, SK; Ward, LC; Wong, WY, 2012)
"The CBT was applied to 48 patients with NAFLD."1.37Non-invasive estimation of liver fibrosis in non-alcoholic fatty liver disease using the 13 C-caffeine breath test. ( Fung, C; George, J; Katelaris, PH; Ngu, MC; Park, GJ; Seow, F; Wiseman, E, 2011)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19903 (12.00)18.7374
1990's1 (4.00)18.2507
2000's2 (8.00)29.6817
2010's17 (68.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Niezen, S1
Mehta, M1
Jiang, ZG1
Tapper, EB1
Albadry, M2
Höpfl, S2
Ehteshamzad, N2
König, M2
Böttcher, M2
Neumann, J2
Lupp, A2
Dirsch, O2
Radde, N2
Christ, B2
Christ, M2
Schwen, LO3
Laue, H2
Klopfleisch, R2
Dahmen, U2
Liu, CW1
Tsai, HC1
Huang, CC1
Tsai, CY1
Su, YB1
Lin, MW1
Lee, KC1
Hsieh, YC1
Li, TH1
Huang, SF1
Yang, YY1
Hou, MC1
Lin, HC1
Lee, FY1
Lee, SD1
Sinha, RA1
Farah, BL1
Singh, BK1
Siddique, MM1
Li, Y1
Wu, Y2
Ilkayeva, OR1
Gooding, J1
Ching, J1
Zhou, J1
Martinez, L1
Xie, S1
Bay, BH1
Summers, SA1
Newgard, CB1
Yen, PM1
Saab, S1
Mallam, D1
Cox, GA1
Tong, MJ1
Wang, L1
Shen, L1
Ping, J1
Zhang, L1
Liu, Z1
Liu, Y1
Huang, H1
Chen, L1
Wang, H1
Zheng, G1
Qiu, Y1
Zhang, QF1
Li, D1
Chirumbolo, S1
Schenk, A1
Kreutz, C1
Timmer, J1
Bartolomé Rodríguez, MM1
Kuepfer, L1
Preusser, T1
Salomone, F1
Galvano, F1
Li Volti, G1
Yun, JW1
Shin, ES1
Cho, SY1
Kim, SH1
Kim, CW1
Lee, TR1
Kim, BH1
Yamauchi, R1
Kobayashi, M1
Matsuda, Y1
Ojika, M1
Shigeoka, S1
Yamamoto, Y1
Tou, Y1
Inoue, T1
Katagiri, T1
Murai, A1
Horio, F1
Tornai, I1
Park, GJ1
Wiseman, E1
George, J1
Katelaris, PH1
Seow, F1
Fung, C1
Ngu, MC1
Molloy, JW1
Calcagno, CJ1
Williams, CD1
Jones, FJ1
Torres, DM1
Harrison, SA1
Birerdinc, A1
Stepanova, M1
Pawloski, L1
Younossi, ZM1
Panchal, SK2
Poudyal, H1
Waanders, J1
Brown, L2
Carrieri, MP1
Sogni, P1
Cohen, J1
Loko, MA1
Winnock, M1
Spire, B1
Wong, WY1
Kauter, K1
Ward, LC1
Anty, R1
Marjoux, S1
Iannelli, A1
Patouraux, S1
Schneck, AS1
Bonnafous, S1
Gire, C1
Amzolini, A1
Ben-Amor, I1
Saint-Paul, MC1
Mariné-Barjoan, E1
Pariente, A1
Gugenheim, J1
Gual, P1
Tran, A1
Schmilovitz-Weiss, H1
Niv, Y1
Pappo, O1
Halpern, M1
Sulkes, J1
Braun, M1
Barak, N1
Rotman, Y1
Cohen, M1
Waked, A1
Tur-Kaspa, R1
Ben-Ari, Z1
Zetterman, RK1
Leevy, CM1
Dianzani, MU1
Muzio, G1
Biocca, ME1
Canuto, RA1
Strubelt, O1
Wegener, F1
Siegers, CP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Inter Cohorts and Clinical Centres Collaborations of Subjects Co-infected With Hepatitis C and Human Immunodeficiency Virus (Collaboration Inter Cohortes et Centres Cliniques de Sujets Co-infectés Par Les Virus de l'immunodéficence Humaine et de l'hépatit[NCT03324633]1,850 participants (Actual)Observational2005-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for caffeine and Fatty Liver

ArticleYear
Impact of coffee on liver diseases: a systematic review.
    Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34, Issue:4

    Topics: Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Caffeine; Carcinoma, Hepatocell

2014
Molecular Bases Underlying the Hepatoprotective Effects of Coffee.
    Nutrients, 2017, Jan-23, Volume: 9, Issue:1

    Topics: Animals; Caffeine; Chlorogenic Acid; Coffee; Disease Models, Animal; Fatty Liver; Humans; Lipid Meta

2017
[Role of environmental factors in the etiology of hepatocellular carcinoma].
    Orvosi hetilap, 2010, Jul-11, Volume: 151, Issue:28

    Topics: Aflatoxins; Alcohol Drinking; Antioxidants; Caffeine; Carcinoma, Hepatocellular; Coffee; Contracepti

2010
Immunologic reactivity and alcoholic liver disease.
    Bulletin of the New York Academy of Medicine, 1975, Volume: 51, Issue:4

    Topics: Acetaldehyde; Alcoholism; Antigen-Antibody Reactions; B-Lymphocytes; Caffeine; Chemical and Drug Ind

1975
Alcohol: another intoxicating instalment.
    Food and cosmetics toxicology, 1970, Volume: 8, Issue:4

    Topics: Alcohol Oxidoreductases; Animals; Barbiturates; Caffeine; Drug Incompatibility; Ethanol; Fatty Liver

1970

Other Studies

20 other studies available for caffeine and Fatty Liver

ArticleYear
Coffee Consumption Is Associated With Lower Liver Stiffness: A Nationally Representative Study.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022, Volume: 20, Issue:9

    Topics: Adult; Beverages; Caffeine; Coffee; Fatty Liver; Humans; Nutrition Surveys; Tea

2022
Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism.
    Scientific reports, 2022, 12-17, Volume: 12, Issue:1

    Topics: Animals; Caffeine; Cytochrome P-450 Enzyme System; Fatty Liver; Metabolic Clearance Rate; Mice; Mida

2022
Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism.
    Scientific reports, 2022, 12-17, Volume: 12, Issue:1

    Topics: Animals; Caffeine; Cytochrome P-450 Enzyme System; Fatty Liver; Metabolic Clearance Rate; Mice; Mida

2022
Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism.
    Scientific reports, 2022, 12-17, Volume: 12, Issue:1

    Topics: Animals; Caffeine; Cytochrome P-450 Enzyme System; Fatty Liver; Metabolic Clearance Rate; Mice; Mida

2022
Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism.
    Scientific reports, 2022, 12-17, Volume: 12, Issue:1

    Topics: Animals; Caffeine; Cytochrome P-450 Enzyme System; Fatty Liver; Metabolic Clearance Rate; Mice; Mida

2022
Effects and mechanisms of caffeine to improve immunological and metabolic abnormalities in diet-induced obese rats.
    American journal of physiology. Endocrinology and metabolism, 2018, 05-01, Volume: 314, Issue:5

    Topics: Adiposity; Animals; Caffeine; Cells, Cultured; Diet, High-Fat; Fatty Liver; Immune System Diseases;

2018
Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.
    Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:4

    Topics: Animals; Autophagy; Caffeine; Cell Line, Tumor; Diet, High-Fat; Down-Regulation; Fatty Liver; Hep G2

2014
Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring.
    Toxicology letters, 2014, Jan-30, Volume: 224, Issue:3

    Topics: Algorithms; Animals; Blood Glucose; Body Weight; Caffeine; Central Nervous System Stimulants; Fatty

2014
Chlorogenic acid and caffeine in combination inhibit fat accumulation by regulating hepatic lipid metabolism-related enzymes in mice.
    The British journal of nutrition, 2014, Sep-28, Volume: 112, Issue:6

    Topics: Acyl-CoA Oxidase; Adiposity; Animals; Caffeine; Carnitine Acyltransferases; Chlorogenic Acid; Dietar

2014
In vivo anti-diabetic potential of chlorogenic acid as a consequence of synergism with other phenolic compounds?
    The British journal of nutrition, 2015, Feb-14, Volume: 113, Issue:3

    Topics: Animals; Caffeine; Chlorogenic Acid; Dietary Supplements; Fatty Liver; Female; Gene Expression Regul

2015
Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Adult; Animals; Blood Circulation; Caffeine; Fatty Liver; Humans; Insulin; Liver; Male; Mice; Models

2015
The effects of BADGE and caffeine on the time-course response of adiponectin and lipid oxidative enzymes in high fat diet-fed C57BL/6J mice: correlation with reduced adiposity and steatosis.
    Experimental animals, 2008, Volume: 57, Issue:5

    Topics: Acetyl-CoA Carboxylase; Adiponectin; Animals; Biphenyl Compounds; Caffeine; Carnitine O-Palmitoyltra

2008
Coffee and caffeine ameliorate hyperglycemia, fatty liver, and inflammatory adipocytokine expression in spontaneously diabetic KK-Ay mice.
    Journal of agricultural and food chemistry, 2010, May-12, Volume: 58, Issue:9

    Topics: Adipokines; Animals; Blood Glucose; Caffeine; Coffee; Diabetes Mellitus, Experimental; Fatty Liver;

2010
Non-invasive estimation of liver fibrosis in non-alcoholic fatty liver disease using the 13 C-caffeine breath test.
    Journal of gastroenterology and hepatology, 2011, Volume: 26, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Biopsy; Breath Tests; Caffeine; Case-Control S

2011
Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis.
    Hepatology (Baltimore, Md.), 2012, Volume: 55, Issue:2

    Topics: Age Factors; Alanine Transaminase; Body Mass Index; Caffeine; Coffee; Fatty Liver; Female; Glycated

2012
Caffeine is protective in patients with non-alcoholic fatty liver disease.
    Alimentary pharmacology & therapeutics, 2012, Volume: 35, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Caffeine; Diet; Fatty Liver; Female; Humans; Liver; Male; Middle Age

2012
Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats.
    The Journal of nutrition, 2012, Volume: 142, Issue:4

    Topics: Animals; Anti-Obesity Agents; Caffeine; Coffee; Diet, High-Fat; Dietary Sucrose; Diterpenes; Fatty L

2012
Elevated coffee consumption and reduced risk of insulin resistance in HIV-HCV coinfected patients (HEPAVIH ANRS CO-13).
    Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:5

    Topics: Caffeine; Coffee; Fatty Liver; Female; Humans; Liver; Liver Cirrhosis; Male

2012
Caffeine attenuates metabolic syndrome in diet-induced obese rats.
    Nutrition (Burbank, Los Angeles County, Calif.), 2012, Volume: 28, Issue:10

    Topics: Adipose Tissue; Animals; Blood Pressure; Caffeine; Cardiovascular System; Diet, High-Fat; Dietary Ca

2012
Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surgery.
    Journal of hepatology, 2012, Volume: 57, Issue:5

    Topics: Adult; Bariatric Surgery; Biopsy; Cacao; Caffeine; Coffee; Cohort Studies; Cola; Comorbidity; Europe

2012
The 13C-caffeine breath test detects significant fibrosis in patients with nonalcoholic steatohepatitis.
    Journal of clinical gastroenterology, 2008, Volume: 42, Issue:4

    Topics: Breath Tests; Caffeine; Carbon Isotopes; Diagnosis, Differential; Fatty Liver; Female; Follow-Up Stu

2008
Lipid peroxidation in fatty liver induced by caffeine in rats.
    International journal of tissue reactions, 1991, Volume: 13, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Fatty Liver; Lipid Peroxidation; Male; Rats;

1991
[Hepatotoxicity of caffeine and theophylline].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:4

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Carbon Tetrachloride Poisoning

1970