Page last updated: 2024-10-24

caffeine and Fatty Liver, Nonalcoholic

caffeine has been researched along with Fatty Liver, Nonalcoholic in 27 studies

Research Excerpts

ExcerptRelevanceReference
"Caffeine intake is associated with a reduced risk developing non-alcoholic fatty liver disease (NAFLD), but the underlying molecular mechanisms remain to be fully elucidated."7.91Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease. ( Akira, S; Cai, X; Fang, C; Fujiwara, N; Hao, S; Hayashi, S; Nishiguchi, S; Sakiyama, H; Sheng, J; Tsutsui, H; Wang, X; Yang, Q, 2019)
"Epigallocatechin-3-gallate (EGCG) and caffeine in tea exert anti-obesity effects and induces nonalcoholic fatty liver disease (NAFLD) amelioration."7.91Coadministration of epigallocatechin-3-gallate (EGCG) and caffeine in low dose ameliorates obesity and nonalcoholic fatty liver disease in obese rats. ( An, HM; Huang, JA; Lin, HY; Liu, ZH; Ou, XC; Wen, BB; Xiong, YF; Yang, Z; Zhang, YB; Zhu, MZ, 2019)
"This study aimed to evaluate female adult offspring induced by prenatal caffeine exposure (PCE) are susceptible to non-alcoholic fatty liver disease (NAFLD) and to explore the underlying programming mechanisms."7.91Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway. ( Hu, S; Luo, H; Wang, H; Xia, L; Xu, D; Xu, Y; Yu, H, 2019)
"Non-alcoholic fatty liver disease (NAFLD) is much more frequent and more severe, including cirrhosis, hepatocellular carcinoma in patients with type 2 diabetes."7.01Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-c ( Adibi, H; Hekmatdoost, A; Mansour, A; Merat, S; Mohajeri-Tehrani, MR; Poustchi, H; Qorbani, M; Samadi, M, 2021)
"Severe NAFLD appeared with higher Kleiner scores."5.40Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring. ( Chen, L; Huang, H; Liu, Y; Liu, Z; Ping, J; Shen, L; Wang, H; Wang, L; Wu, Y; Zhang, L, 2014)
"The association of CC with nonalcoholic fatty liver disease (NAFLD) has not been established."5.38Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis. ( Calcagno, CJ; Harrison, SA; Jones, FJ; Molloy, JW; Torres, DM; Williams, CD, 2012)
"Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is the most common cause of primary liver disease."5.38Caffeine is protective in patients with non-alcoholic fatty liver disease. ( Birerdinc, A; Pawloski, L; Stepanova, M; Younossi, ZM, 2012)
"The CBT was applied to 48 patients with NAFLD."5.37Non-invasive estimation of liver fibrosis in non-alcoholic fatty liver disease using the 13 C-caffeine breath test. ( Fung, C; George, J; Katelaris, PH; Ngu, MC; Park, GJ; Seow, F; Wiseman, E, 2011)
" We used a combination of the keywords "coffee", "caffeine", "tea", "non-alcoholic fatty liver disease", "non-alcoholic steatohepatitis", "metabolic syndrome"."4.93Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies. ( Del Rio, D; Godos, J; Grosso, G; Marventano, S; Mistretta, A; Pluchinotta, F; Salomone, F, 2016)
"Caffeine intake is associated with a reduced risk developing non-alcoholic fatty liver disease (NAFLD), but the underlying molecular mechanisms remain to be fully elucidated."3.91Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease. ( Akira, S; Cai, X; Fang, C; Fujiwara, N; Hao, S; Hayashi, S; Nishiguchi, S; Sakiyama, H; Sheng, J; Tsutsui, H; Wang, X; Yang, Q, 2019)
"Epigallocatechin-3-gallate (EGCG) and caffeine in tea exert anti-obesity effects and induces nonalcoholic fatty liver disease (NAFLD) amelioration."3.91Coadministration of epigallocatechin-3-gallate (EGCG) and caffeine in low dose ameliorates obesity and nonalcoholic fatty liver disease in obese rats. ( An, HM; Huang, JA; Lin, HY; Liu, ZH; Ou, XC; Wen, BB; Xiong, YF; Yang, Z; Zhang, YB; Zhu, MZ, 2019)
"This study aimed to evaluate female adult offspring induced by prenatal caffeine exposure (PCE) are susceptible to non-alcoholic fatty liver disease (NAFLD) and to explore the underlying programming mechanisms."3.91Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway. ( Hu, S; Luo, H; Wang, H; Xia, L; Xu, D; Xu, Y; Yu, H, 2019)
"The beneficial effect of caffeine-containing food on non-alcoholic fatty liver disease (NAFLD) has been widely reported."3.81Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway. ( Cao, LF; Chen, M; He, RR; Kurihara, H; Li, YF; Mao, GW; Tan, RR; Tsoi, B; Wang, GE; Wang, Q; Zhai, YJ; Zhang, SJ, 2015)
"Caffeine, the main component of coffee, has showed its protective effect on non-alcoholic fatty liver disease (NAFLD) in many studies."3.81Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae. ( Chen, X; Dai, W; Hou, J; Liu, L; Wang, K; Zhang, W; Zheng, X, 2015)
"Non-alcoholic fatty liver disease (NAFLD) is much more frequent and more severe, including cirrhosis, hepatocellular carcinoma in patients with type 2 diabetes."3.01Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-c ( Adibi, H; Hekmatdoost, A; Mansour, A; Merat, S; Mohajeri-Tehrani, MR; Poustchi, H; Qorbani, M; Samadi, M, 2021)
" This study aimed to build a physiologically based pharmacokinetic (PBPK) model reflecting observed changes in physiological and molecular parameters relevant to drug disposition that are associated with MAFLD."2.82A Physiologically Based Pharmacokinetic Model to Predict the Impact of Metabolic Changes Associated with Metabolic Associated Fatty Liver Disease on Drug Exposure. ( Newman, EM; Rowland, A, 2022)
"Caffeine was administered orally at a daily dose of 50 mg/kg body weight during the period of NASH induction to evaluate its ability to prevent disease development."1.91The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats. ( Acero-Hernández, C; Cardoso-Lezama, I; Galindo-Gómez, S; Muriel, P; Ramos-Tovar, E; Tsutsumi, V; Vargas-Pozada, EE, 2023)
"Caffeine treatment significantly decreased the elevated serum ALT, AST, and bilirubin and increased the reduced albumin level."1.48Caffeine affects HFD-induced hepatic steatosis by multifactorial intervention. ( Ayoub, SE; Elkashefand, WF; Helal, MG; Ibrahim, TM, 2018)
"Metabolic syndrome is one of the most important health issues worldwide."1.46Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice. ( Baba, H; Morimoto, Y; Ogawa, H; Takahashi, T; Tsunematsu, T; Tsuneyama, K; Uehara, H; Watanabe, S, 2017)
"Non-alcoholic fatty liver disease (NAFLD) characterizes and predicts T2DM yet the relationship of coffee with this disorder remains unclear."1.42Associations of coffee consumption with markers of liver injury in the insulin resistance atherosclerosis study. ( Dickson, JC; Haffner, SM; Hamren, SJ; Hanley, AJ; Liese, AD; Lorenzo, C; Stiles, JK; Wagenknecht, LE; Watkins, SM, 2015)
"Severe NAFLD appeared with higher Kleiner scores."1.40Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring. ( Chen, L; Huang, H; Liu, Y; Liu, Z; Ping, J; Shen, L; Wang, H; Wang, L; Wu, Y; Zhang, L, 2014)
"The association of CC with nonalcoholic fatty liver disease (NAFLD) has not been established."1.38Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis. ( Calcagno, CJ; Harrison, SA; Jones, FJ; Molloy, JW; Torres, DM; Williams, CD, 2012)
"Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is the most common cause of primary liver disease."1.38Caffeine is protective in patients with non-alcoholic fatty liver disease. ( Birerdinc, A; Pawloski, L; Stepanova, M; Younossi, ZM, 2012)
"The CBT was applied to 48 patients with NAFLD."1.37Non-invasive estimation of liver fibrosis in non-alcoholic fatty liver disease using the 13 C-caffeine breath test. ( Fung, C; George, J; Katelaris, PH; Ngu, MC; Park, GJ; Seow, F; Wiseman, E, 2011)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's18 (66.67)24.3611
2020's9 (33.33)2.80

Authors

AuthorsStudies
Fan, Z1
Wang, C1
Yang, T1
Gao, T1
Wang, D1
Zhao, X1
Guo, X2
Li, D1
Kakiyama, G1
Minowa, K1
Rodriguez-Agudo, D1
Martin, R1
Takei, H1
Mitamura, K1
Ikegawa, S1
Suzuki, M1
Nittono, H1
Fuchs, M1
Heuman, DM1
Zhou, H1
Pandak, WM1
Newman, EM1
Rowland, A1
Vargas-Pozada, EE1
Ramos-Tovar, E1
Acero-Hernández, C1
Cardoso-Lezama, I1
Galindo-Gómez, S1
Tsutsumi, V1
Muriel, P1
Dranoff, JA1
Zhang, C1
Zhang, D1
Huang, H2
Lu, X1
Shi, H1
Liu, K1
Zhang, R1
Wang, H4
Velázquez, AM1
Roglans, N1
Bentanachs, R1
Gené, M1
Sala-Vila, A1
Lázaro, I1
Rodríguez-Morató, J1
Sánchez, RM1
Laguna, JC1
Alegret, M1
Mansour, A1
Mohajeri-Tehrani, MR1
Samadi, M1
Qorbani, M1
Merat, S1
Adibi, H1
Poustchi, H1
Hekmatdoost, A1
Sewter, R1
Heaney, S1
Patterson, A1
Watanabe, S1
Takahashi, T1
Ogawa, H1
Uehara, H1
Tsunematsu, T1
Baba, H1
Morimoto, Y1
Tsuneyama, K1
Helal, MG1
Ayoub, SE1
Elkashefand, WF1
Ibrahim, TM1
Fang, C1
Cai, X1
Hayashi, S1
Hao, S1
Sakiyama, H1
Wang, X1
Yang, Q1
Akira, S1
Nishiguchi, S1
Fujiwara, N1
Tsutsui, H1
Sheng, J1
Yang, Z1
Zhu, MZ1
Zhang, YB1
Wen, BB1
An, HM1
Ou, XC1
Xiong, YF1
Lin, HY1
Liu, ZH1
Huang, JA1
Hu, S2
Xia, L1
Luo, H1
Xu, Y1
Yu, H1
Xu, D1
He, B1
Wen, Y1
Wang, G1
Hu, W1
Magdalou, J1
Chen, L2
Saab, S1
Mallam, D1
Cox, GA1
Tong, MJ1
Wang, L1
Shen, L1
Ping, J1
Zhang, L1
Liu, Z1
Wu, Y1
Liu, Y1
Zhang, SJ1
Li, YF1
Wang, GE1
Tan, RR1
Tsoi, B1
Mao, GW1
Zhai, YJ1
Cao, LF1
Chen, M1
Kurihara, H1
Wang, Q1
He, RR1
Dickson, JC1
Liese, AD1
Lorenzo, C1
Haffner, SM1
Watkins, SM1
Hamren, SJ1
Stiles, JK1
Wagenknecht, LE1
Hanley, AJ1
Graeter, T1
Niedermayer, PC1
Mason, RA1
Oeztuerk, S1
Haenle, MM1
Koenig, W1
Boehm, BO1
Kratzer, W1
Zheng, X1
Dai, W1
Chen, X1
Wang, K1
Zhang, W1
Liu, L1
Hou, J1
Marventano, S1
Salomone, F1
Godos, J1
Pluchinotta, F1
Del Rio, D1
Mistretta, A1
Grosso, G1
Park, GJ1
Wiseman, E1
George, J1
Katelaris, PH1
Seow, F1
Fung, C1
Ngu, MC1
Molloy, JW1
Calcagno, CJ1
Williams, CD1
Jones, FJ1
Torres, DM1
Harrison, SA1
Birerdinc, A1
Stepanova, M1
Pawloski, L1
Younossi, ZM1
Panchal, SK1
Poudyal, H1
Waanders, J1
Brown, L1
Anty, R1
Marjoux, S1
Iannelli, A1
Patouraux, S1
Schneck, AS1
Bonnafous, S1
Gire, C1
Amzolini, A1
Ben-Amor, I1
Saint-Paul, MC1
Mariné-Barjoan, E1
Pariente, A1
Gugenheim, J1
Gual, P1
Tran, A1

Reviews

5 reviews available for caffeine and Fatty Liver, Nonalcoholic

ArticleYear
A Physiologically Based Pharmacokinetic Model to Predict the Impact of Metabolic Changes Associated with Metabolic Associated Fatty Liver Disease on Drug Exposure.
    International journal of molecular sciences, 2022, Oct-04, Volume: 23, Issue:19

    Topics: Animals; Caffeine; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dextromethorp

2022
Coffee as chemoprotectant in fatty liver disease: caffeine-dependent and caffeine-independent effects.
    American journal of physiology. Gastrointestinal and liver physiology, 2023, 06-01, Volume: 324, Issue:6

    Topics: Caffeine; Coffee; Humans; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease

2023
Coffee Consumption and the Progression of NAFLD: A Systematic Review.
    Nutrients, 2021, Jul-12, Volume: 13, Issue:7

    Topics: Caffeine; Coffee; Cross-Sectional Studies; Disease Progression; Female; Humans; Liver Cirrhosis; Mal

2021
Impact of coffee on liver diseases: a systematic review.
    Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34, Issue:4

    Topics: Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Caffeine; Carcinoma, Hepatocell

2014
Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies.
    Clinical nutrition (Edinburgh, Scotland), 2016, Volume: 35, Issue:6

    Topics: Caffeine; Coffee; Diet; Humans; Liver Cirrhosis; MEDLINE; Metabolic Syndrome; Non-alcoholic Fatty Li

2016

Trials

1 trial available for caffeine and Fatty Liver, Nonalcoholic

ArticleYear
Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-c
    Nutrition journal, 2021, 04-10, Volume: 20, Issue:1

    Topics: Caffeine; Chlorogenic Acid; Coffee; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Met

2021

Other Studies

21 other studies available for caffeine and Fatty Liver, Nonalcoholic

ArticleYear
Coffee peel extracts ameliorate non-alcoholic fatty liver disease
    Food & function, 2022, Jul-04, Volume: 13, Issue:13

    Topics: Adiponectin; Animals; Caffeine; Coffee; Diet, High-Fat; Fibroblast Growth Factors; Flavonoids; Liver

2022
Coffee modulates insulin-hepatocyte nuclear factor-4α-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model.
    American journal of physiology. Gastrointestinal and liver physiology, 2022, 11-01, Volume: 323, Issue:5

    Topics: Animals; Caffeine; Cholesterol; Coffee; Cytochrome P450 Family 7; Disease Models, Animal; Hepatitis;

2022
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats.
    Canadian journal of physiology and pharmacology, 2023, Mar-01, Volume: 101, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Caffeine; Cytokines; Humans; Liver; Male; NF-E2-Rel

2023
Cathepsin D mediates prenatal caffeine exposure-caused NAFLD susceptibility in male rat offspring by regulating autophagy.
    Free radical biology & medicine, 2023, 11-01, Volume: 208

    Topics: Animals; Autophagy; Caffeine; Cathepsin D; Corticosterone; Female; Humans; Male; MicroRNAs; Non-alco

2023
Effects of a Low Dose of Caffeine Alone or as Part of a Green Coffee Extract, in a Rat Dietary Model of Lean Non-Alcoholic Fatty Liver Disease without Inflammation.
    Nutrients, 2020, Oct-23, Volume: 12, Issue:11

    Topics: Animals; Caffeine; Coffee; Diet, High-Fat; Dietary Fats; Dietary Supplements; Disease Models, Animal

2020
Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice.
    Metabolic syndrome and related disorders, 2017, Volume: 15, Issue:4

    Topics: Aging; Animals; Caffeine; Coffee; Diabetes Mellitus, Type 2; Hyperlipidemias; Insulin-Secreting Cell

2017
Caffeine affects HFD-induced hepatic steatosis by multifactorial intervention.
    Human & experimental toxicology, 2018, Volume: 37, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Caffeine; Cytoprotection; Diet, High-Fa

2018
Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019, Volume: 1864, Issue:3

    Topics: Adipocytes; Animals; Caffeine; Diet, High-Fat; Disease Models, Animal; Hepatocytes; Interleukin-6; L

2019
Coadministration of epigallocatechin-3-gallate (EGCG) and caffeine in low dose ameliorates obesity and nonalcoholic fatty liver disease in obese rats.
    Phytotherapy research : PTR, 2019, Volume: 33, Issue:4

    Topics: Animals; Body Weight; Caffeine; Catechin; Diet, High-Fat; Dose-Response Relationship, Drug; Drug The

2019
Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway.
    Toxicology, 2019, 04-01, Volume: 417

    Topics: Animals; Caffeine; CCAAT-Binding Factor; Dose-Response Relationship, Drug; Female; Non-alcoholic Fat

2019
Prenatal caffeine exposure induces liver developmental dysfunction in offspring rats.
    The Journal of endocrinology, 2019, 07-26, Volume: 242, Issue:3

    Topics: Animals; Caffeine; Corticosterone; Female; Fetal Development; Fetal Growth Retardation; Gene Express

2019
Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring.
    Toxicology letters, 2014, Jan-30, Volume: 224, Issue:3

    Topics: Algorithms; Animals; Blood Glucose; Body Weight; Caffeine; Central Nervous System Stimulants; Fatty

2014
Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway.
    Food & function, 2015, Volume: 6, Issue:8

    Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Caffeine; CREB-Binding Protein; Diet

2015
Associations of coffee consumption with markers of liver injury in the insulin resistance atherosclerosis study.
    BMC gastroenterology, 2015, Jul-28, Volume: 15

    Topics: Alanine Transaminase; alpha-2-HS-Glycoprotein; Aspartate Aminotransferases; Biomarkers; Caffeine; Co

2015
Coffee consumption and NAFLD: a community based study on 1223 subjects.
    BMC research notes, 2015, Nov-03, Volume: 8

    Topics: Adolescent; Adult; Aged; Alanine Transaminase; Body Mass Index; Caffeine; Central Nervous System Sti

2015
Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae.
    Journal of biomedical science, 2015, Nov-17, Volume: 22

    Topics: Animals; Caffeine; Endoplasmic Reticulum Stress; Humans; Lipids; Lipogenesis; Liver; Non-alcoholic F

2015
Non-invasive estimation of liver fibrosis in non-alcoholic fatty liver disease using the 13 C-caffeine breath test.
    Journal of gastroenterology and hepatology, 2011, Volume: 26, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Biopsy; Breath Tests; Caffeine; Case-Control S

2011
Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis.
    Hepatology (Baltimore, Md.), 2012, Volume: 55, Issue:2

    Topics: Age Factors; Alanine Transaminase; Body Mass Index; Caffeine; Coffee; Fatty Liver; Female; Glycated

2012
Caffeine is protective in patients with non-alcoholic fatty liver disease.
    Alimentary pharmacology & therapeutics, 2012, Volume: 35, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Caffeine; Diet; Fatty Liver; Female; Humans; Liver; Male; Middle Age

2012
Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats.
    The Journal of nutrition, 2012, Volume: 142, Issue:4

    Topics: Animals; Anti-Obesity Agents; Caffeine; Coffee; Diet, High-Fat; Dietary Sucrose; Diterpenes; Fatty L

2012
Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surgery.
    Journal of hepatology, 2012, Volume: 57, Issue:5

    Topics: Adult; Bariatric Surgery; Biopsy; Cacao; Caffeine; Coffee; Cohort Studies; Cola; Comorbidity; Europe

2012