Page last updated: 2024-10-24

caffeine and Epilepsy

caffeine has been researched along with Epilepsy in 61 studies

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"We randomly assigned 2006 infants with birth weights of 500 to 1250 g to receive either caffeine or placebo until therapy for apnea of prematurity was no longer needed."9.12Long-term effects of caffeine therapy for apnea of prematurity. ( Barrington, KJ; Davis, P; Doyle, LW; Ohlsson, A; Roberts, RS; Schmidt, B; Solimano, A; Tin, W, 2007)
"The relationship between caffeine, seizures, epilepsy, and anti-seizure drugs is not fully understood."9.01The Use of Caffeine by People with Epilepsy: the Myths and the Evidence. ( Bauer, PR; Sander, JW, 2019)
"PubMed was searched for studies assessing the effects of caffeine on seizure susceptibility, epilepsy, and drug interactions in people and in animal models."8.98Caffeine and seizures: A systematic review and quantitative analysis. ( Bauer, PR; Sander, JW; Schuitema, I; van Koert, RR; Visser, GH, 2018)
"Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy."7.78The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. ( Kanda, T; Takizawa, F; Tamura, T; Yamada, K, 2012)
"Seizures and epilepsy are associated with significant disability and substantial treatment costs, yet little is known about primary prevention."5.36A prospective study of smoking, caffeine, and alcohol as risk factors for seizures or epilepsy in young adult women: data from the Nurses' Health Study II. ( Bromfield, EB; Dworetzky, BA; Kang, JH; Townsend, MK, 2010)
"We randomly assigned 2006 infants with birth weights of 500 to 1250 g to receive either caffeine or placebo until therapy for apnea of prematurity was no longer needed."5.12Long-term effects of caffeine therapy for apnea of prematurity. ( Barrington, KJ; Davis, P; Doyle, LW; Ohlsson, A; Roberts, RS; Schmidt, B; Solimano, A; Tin, W, 2007)
"The relationship between caffeine, seizures, epilepsy, and anti-seizure drugs is not fully understood."5.01The Use of Caffeine by People with Epilepsy: the Myths and the Evidence. ( Bauer, PR; Sander, JW, 2019)
"PubMed was searched for studies assessing the effects of caffeine on seizure susceptibility, epilepsy, and drug interactions in people and in animal models."4.98Caffeine and seizures: A systematic review and quantitative analysis. ( Bauer, PR; Sander, JW; Schuitema, I; van Koert, RR; Visser, GH, 2018)
"Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy."3.78The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. ( Kanda, T; Takizawa, F; Tamura, T; Yamada, K, 2012)
" Apart from the hyponatremia due to water intoxication the convulsions can be potentiated by the high dose of caffeine and aspartame from the diet coke."3.74Seizures and hyponatremia after excessive intake of diet coke. ( De Cauwer, HG; Merlevede, K; Mortelmans, LJ; Van Loo, M, 2008)
"The use of cocaine is associated with the occurrence of seizures."3.71Psychostimulants and epilepsy. ( Albano, C; Zagnoni, PG, 2002)
"Children due to receive carbamazepine for epilepsy were recruited into the study."3.70Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test. ( Choonara, I; Parker, AC; Preston, T; Pritchard, P, 1998)
"Carbamazepine (CBZ) is known to have beneficial effects in the treatment of epilepsies and in the prophylaxis of affective disorders."3.68Calcium-antagonistic effects of carbamazepine in epilepsies and affective psychoses. ( Bingmann, D; Düsing, R; Grunze, H; Liu, Z; Mayer, A; Schirrmacher, K; Walden, J, 1993)
"The present study evaluates effect of pharmacokinetic interaction between caffeine (300 mg) in three divided doses with sodium valproate (400 mg) and carbamazepine (200 mg) given as single doses, in normal human volunteers, using a open cross over design."2.69Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers. ( David, J; Joseph, T; Kulkarni, C; Vaz, J, 1998)
"Seizures and epilepsy are associated with significant disability and substantial treatment costs, yet little is known about primary prevention."1.36A prospective study of smoking, caffeine, and alcohol as risk factors for seizures or epilepsy in young adult women: data from the Nurses' Health Study II. ( Bromfield, EB; Dworetzky, BA; Kang, JH; Townsend, MK, 2010)
"Caffeine is a mixed adenosine receptor antagonist, therefore its effects could be due to a different action on adenosine receptor subtypes; an additional mechanism of action cannot be excluded."1.33Biphasic effect of chronic postnatal caffeine treatment on cortical epileptic afterdischarges during ontogeny in rats. ( Kubová, H; Mares, P; Tchekalarova, J, 2006)
"The grave course of epilepsy is associated with a decrease of the LCBF on the side of the focus."1.28[Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy]. ( Shestakov, VV; Shutov, AA, 1990)
"Phenytoin treatment may impair the validity of the caffeine liver function test."1.28Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism. ( Büchsel, R; Kohl, D; Kreiten, K; Matern, S; Wietholtz, H; Zysset, T, 1989)

Research

Studies (61)

TimeframeStudies, this research(%)All Research%
pre-199022 (36.07)18.7374
1990's13 (21.31)18.2507
2000's10 (16.39)29.6817
2010's14 (22.95)24.3611
2020's2 (3.28)2.80

Authors

AuthorsStudies
Asadi-Pooya, AA1
Zeraatpisheh, Z1
Rostaminejad, M1
Damabi, NM1
Di Rocco, M1
Galosi, S1
Follo, FC1
Lanza, E1
Folli, V1
Martire, A1
Leuzzi, V1
Martinelli, S1
Schaf, J1
Damstra-Oddy, J1
Williams, RSB1
van Koert, RR1
Bauer, PR2
Schuitema, I1
Sander, JW2
Visser, GH1
Rubi, L1
Schandl, U1
Lagler, M1
Geier, P1
Spies, D1
Gupta, KD1
Boehm, S1
Kubista, H1
Tchekalarova, J3
Kubová, H3
Mareš, P3
Turan, MI1
Tan, H1
Cetin, N1
Suleyman, H2
Cayir, A1
Chrościńska-Krawczyk, M2
Radzik, I1
Miziak, B1
Czuczwar, SJ2
Shen, HY1
Li, T1
Boison, D2
Dworetzky, BA1
Bromfield, EB1
Townsend, MK1
Kang, JH1
Borekci, B1
Ingec, M1
Yilmaz, M1
Kukula, O1
Karaca, M1
Hacimuftuoglu, A1
Halici, Z1
Jargiełło-Baszak, M1
Wałek, M1
Tylus, B1
Lusardi, TA1
Lytle, NK1
Szybala, C1
Yamada, K1
Takizawa, F1
Tamura, T1
Kanda, T1
Angehagen, M1
Margineanu, DG2
Ben-Menachem, E1
Rönnbäck, L1
Hansson, E1
Klitgaard, H2
KETZ, E1
BOROFFKA, A1
LUSTIG, B1
EZIMA, I1
IMAI, T1
EYSOLD, R1
MOELLHOFF, G1
REMEZOVA, ES1
SAFONOVA, SA1
CHAO, NT1
LI, PJ1
JUNOD, JP1
MARTIN, F1
Uzbay, TI1
Kayir, H1
Ceyhan, M1
Schmidt, B1
Roberts, RS1
Davis, P1
Doyle, LW1
Barrington, KJ1
Ohlsson, A1
Solimano, A1
Tin, W1
Mortelmans, LJ1
Van Loo, M1
De Cauwer, HG1
Merlevede, K1
Neyraut-Sutterman, MT1
Harrison, A1
Gerlach, J1
Moraidis, I2
Bingmann, D4
Walden, J1
Grunze, H1
Mayer, A1
Düsing, R1
Schirrmacher, K1
Liu, Z1
Bonnet, U1
Francis, A1
Fochtmann, L1
De Sarro, A1
Grasso, S1
Zappala, M1
Nava, F1
De Sarro, G1
Tran, A1
Rey, E1
Pons, G1
Rousseau, M1
d'Athis, P1
Olive, G1
Mather, GG1
Bishop, FE1
Wurden, CJ1
Labroo, R1
Trager, WF1
Kunze, KL1
Thummel, KE1
Vincent, JC1
Gillardin, JM1
Lepage, F1
Levy, RH1
Parker, AC1
Pritchard, P1
Preston, T1
Choonara, I1
Vaz, J1
Kulkarni, C1
David, J1
Joseph, T1
Dzhala, V1
Desfreres, L1
Melyan, Z1
Ben-Ari, Y1
Khazipov, R1
Jin, W1
Sugaya, A1
Tsuda, T1
Ohguchi, H1
Sugaya, E1
Hashiguchi, W1
Nagatomo, I1
Akasaki, Y1
Uchida, M1
Tominaga, M1
Takigawa, M1
Lara, DR1
Schmidt, AP1
Frizzo, ME1
Burgos, JS1
Ramírez, G1
Souza, DO1
Zagnoni, PG1
Albano, C1
Shutov, AA2
Pleshkova, NM1
Shestakov, VV2
Pozdniakov, VS1
Dudkin, AO1
Lehmenkühler, A1
Speckmann, EJ1
Bologa, M1
Tang, B1
Klein, J1
Tesoro, A1
Koren, G1
Wietholtz, H1
Zysset, T1
Kreiten, K1
Kohl, D1
Büchsel, R1
Matern, S1
Frank, C2
Sagratella, S2
Benedetti, M2
Scotti de Carolis, A2
Maitre, M1
Chesielski, L1
Lehmann, A1
Kempf, E1
Mandel, P1
Zappoli, R1
Papini, M1
Brunia, CH1
Buyze, G1
Rupollo, W2
Shmilovich, LA1
Poliak, AI1
Hess, R1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake[NCT01168687]46 participants (Actual)Interventional2008-11-30Completed
Multicenter, Comparative, Randomized, Open Trial to Evaluate Efficacy and Safety of Levetiracetam Versus Carbamazepine in Post Stroke Late Onset Crisis[NCT00542802]Phase 3630 participants (Anticipated)Interventional2007-09-30Recruiting
A Prospective, Controlled Trial of Inhalation of Low Concentration of CO2 in Preterm Infants Not Responding to Caffeine for the Treatment of Apnea of Prematurity[NCT01911182]Phase 2/Phase 37 participants (Actual)Interventional2011-10-31Terminated (stopped due to Low recruitment rate)
Efficacy and Safety of Methylxanthines in Very Low Birthweight Infants[NCT00182312]Phase 32,000 participants (Anticipated)Interventional1999-10-31Completed
Long-Term Effects On Sleep Of Methylxanthine Therapy For Apnea Of Prematurity[NCT01020357]Phase 3201 participants (Actual)Interventional2009-11-30Completed
[NCT01066728]Phase 2/Phase 387 participants (Actual)Interventional2001-08-31Completed
A Randomized, Placebo-controlled Trial of Early Caffeine in Preterm Neonates[NCT03086473]Phase 424 participants (Actual)Interventional2017-02-01Active, not recruiting
Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia[NCT05295784]Phase 118 participants (Anticipated)Interventional2024-06-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Standard Alcoholic Drinks Per Treatment Period

The primary outcome of this study is to determine the effect of levetiracetam on alcohol consumption as measured by change in # of drinks during each treatment period. (NCT01168687)
Timeframe: During each 14 day treatment period

Interventionnumber of drinks per treatment period (Mean)
All Subjects (n = 46) Placebo41.2
All Subjects (n = 46) Levetiracetam45.4

Reviews

6 reviews available for caffeine and Epilepsy

ArticleYear
Caffeinated drinks, fruit juices, and epilepsy: A systematic review.
    Acta neurologica Scandinavica, 2022, Volume: 145, Issue:2

    Topics: Caffeine; Coffee; Epilepsy; Fruit and Vegetable Juices; Humans

2022
Dictyostelium discoideum as a pharmacological model system to study the mechanisms of medicinal drugs and natural products.
    The International journal of developmental biology, 2019, Volume: 63, Issue:8-9-10

    Topics: Animals; Anti-Infective Agents; Bacterial Infections; Biological Products; Bipolar Disorder; Caffein

2019
Caffeine and seizures: A systematic review and quantitative analysis.
    Epilepsy & behavior : E&B, 2018, Volume: 80

    Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Drug Interactions; Epilepsy;

2018
The Use of Caffeine by People with Epilepsy: the Myths and the Evidence.
    Current neurology and neuroscience reports, 2019, 05-14, Volume: 19, Issue:6

    Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Epilepsy; Humans; Seizures

2019
Safety considerations for patients with epilepsy taking antiepileptic drugs alongside caffeine or other methylxanthine derivatives.
    Expert opinion on drug metabolism & toxicology, 2014, Volume: 10, Issue:7

    Topics: Aminophylline; Animals; Anticonvulsants; Caffeine; Coffee; Drug Interactions; Epilepsy; Humans; Theo

2014
Caffeine and the anticonvulsant potency of antiepileptic drugs: experimental and clinical data.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:1

    Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Drug

2011

Trials

2 trials available for caffeine and Epilepsy

ArticleYear
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Long-term effects of caffeine therapy for apnea of prematurity.
    The New England journal of medicine, 2007, Nov-08, Volume: 357, Issue:19

    Topics: Apnea; Body Size; Caffeine; Central Nervous System Stimulants; Cerebral Palsy; Citrates; Development

2007
Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers.
    Indian journal of experimental biology, 1998, Volume: 36, Issue:1

    Topics: Anticonvulsants; Caffeine; Carbamazepine; Cross-Over Studies; Drug Interactions; Epilepsy; Humans; M

1998

Other Studies

53 other studies available for caffeine and Epilepsy

ArticleYear
Phenotypic Assessment of Pathogenic Variants in
    Genes, 2023, 01-26, Volume: 14, Issue:2

    Topics: Animals; Caenorhabditis elegans; Caffeine; Epilepsy; GTP-Binding Proteins; Mutation

2023
Raised activity of L-type calcium channels renders neurons prone to form paroxysmal depolarization shifts.
    Neuromolecular medicine, 2013, Volume: 15, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2013
Effects of caffeine on cortical epileptic afterdischarges in adult rats are modulated by postnatal treatment.
    Acta neurologica Belgica, 2013, Volume: 113, Issue:4

    Topics: Aging; Animals; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Disease Models, Animal

2013
Effects of thiamine and thiamine pyrophosphate on epileptic episode model established with caffeine in rats.
    Epilepsy research, 2014, Volume: 108, Issue:3

    Topics: Animals; Brain; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response R

2014
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Cause of De

2010
A prospective study of smoking, caffeine, and alcohol as risk factors for seizures or epilepsy in young adult women: data from the Nurses' Health Study II.
    Epilepsia, 2010, Volume: 51, Issue:2

    Topics: Adult; Age Distribution; Alcohol Drinking; Caffeine; Epilepsy; Female; Health Status; Humans; Incide

2010
Effects of female sex hormones on caffeine-induced epileptiform activity in rats.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2010, Volume: 26, Issue:5

    Topics: Animals; Caffeine; Corticosterone; Epilepsy; Epinephrine; Estrogen Antagonists; Estrogens; Female; F

2010
Postnatal period of caffeine treatment and time of testing modulate the effect of acute caffeine on cortical epileptic afterdischarges in rats.
    Brain research, 2010, Oct-14, Volume: 1356

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Anticonvulsants; Caffeine; Cerebral Cortex; Con

2010
Caffeine prevents acute mortality after TBI in rats without increased morbidity.
    Experimental neurology, 2012, Volume: 234, Issue:1

    Topics: Animals; Brain Injuries; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Dose-R

2012
The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:5

    Topics: Age Factors; Animals; Anti-Allergic Agents; Brain; Caffeine; Central Nervous System Stimulants; Dibe

2012
Levetiracetam reduces caffeine-induced Ca2+ transients and epileptiform potentials in hippocampal neurons.
    Neuroreport, 2003, Mar-03, Volume: 14, Issue:3

    Topics: Animals; Anticonvulsants; Caffeine; Calcium; Cells, Cultured; Central Nervous System Stimulants; Ele

2003
Levetiracetam reduces caffeine-induced Ca2+ transients and epileptiform potentials in hippocampal neurons.
    Neuroreport, 2003, Mar-03, Volume: 14, Issue:3

    Topics: Animals; Anticonvulsants; Caffeine; Calcium; Cells, Cultured; Central Nervous System Stimulants; Ele

2003
Levetiracetam reduces caffeine-induced Ca2+ transients and epileptiform potentials in hippocampal neurons.
    Neuroreport, 2003, Mar-03, Volume: 14, Issue:3

    Topics: Animals; Anticonvulsants; Caffeine; Calcium; Cells, Cultured; Central Nervous System Stimulants; Ele

2003
Levetiracetam reduces caffeine-induced Ca2+ transients and epileptiform potentials in hippocampal neurons.
    Neuroreport, 2003, Mar-03, Volume: 14, Issue:3

    Topics: Animals; Anticonvulsants; Caffeine; Calcium; Cells, Cultured; Central Nervous System Stimulants; Ele

2003
[Results with the combined preparation apydan in therapy of symptomatic epilepsy].
    Arztliche Wochenschrift, 1956, May-25, Volume: 11, Issue:20-21

    Topics: Barbiturates; Bromides; Caffeine; Epilepsy; Humans; Hydantoins

1956
[Epilepsy therapy with the combination preparation centronal compositum].
    Munchener medizinische Wochenschrift (1950), 1957, Jan-25, Volume: 99, Issue:4

    Topics: Aminopyrine; Caffeine; Epilepsy; Humans; Hydantoins; Phenobarbital; Porphyrins

1957
[Therapeutic effect of Diurex on epilepsy].
    No to shinkei = Brain and nerve, 1961, Volume: 13

    Topics: Anticonvulsants; Caffeine; Diuretics; Epilepsy; Salicylates

1961
[GENESIS, CLASSIFICATION AND THERAPY OF LOSS OF CONSCIOUSNESS].
    Monatsschrift fur Kinderheilkunde, 1963, Volume: 111

    Topics: Caffeine; Child; Classification; Electroencephalography; Epilepsy; Epilepsy, Absence; Humans; Oxyphe

1963
[INCIDENTS IN REID'S INTRACISTERNAL THERAPY WITH PROCAINE-CAFFEINE MIXTURES].
    Die Medizinische Welt, 1963, Nov-23, Volume: 47

    Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Caffeine; Encephalomyelitis; Epilepsy; Headache;

1963
[TREATMENT OF PATIENTS WITH EPILEPSY WITH FREQUENT PETIT MAL SEIZURES].
    Sovetskaia meditsina, 1964, Volume: 27

    Topics: Anticonvulsants; Caffeine; Drug Therapy; Epilepsy; Epilepsy, Absence; Humans; Phenobarbital; Seizure

1964
[THE ANTICONVULSANT ACTIVITY OF ARISAEMA JAPONICUM BL].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1964, Volume: 11

    Topics: Anticonvulsants; Arisaema; Caffeine; Electric Injuries; Epilepsy; Mice; Pentylenetetrazole; Pharmaco

1964
[Introduction of caffeine in high doses in the treatment of epilepsy. Study of a special aspect of anticonvulsant pharmacotherapy].
    Psychiatria et neurologia, 1960, Volume: 139

    Topics: Anticonvulsants; Caffeine; Epilepsy

1960
Caffeine-induced epileptiform field potentials in rat hippocampal slices: a pharmacological characterization.
    Neuropharmacology, 2004, Volume: 47, Issue:6

    Topics: 2-Chloroadenosine; Animals; Anticonvulsants; Caffeine; Calcium; Calcium Channel Blockers; Calcium Si

2004
Biphasic effect of chronic postnatal caffeine treatment on cortical epileptic afterdischarges during ontogeny in rats.
    Brain research, 2006, Apr-12, Volume: 1082, Issue:1

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Central Nervous System Stimu

2006
Effects of tianeptine on onset time of pentylenetetrazole-induced seizures in mice: possible role of adenosine A1 receptors.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:2

    Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antidep

2007
Seizures and hyponatremia after excessive intake of diet coke.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2008, Volume: 15, Issue:1

    Topics: Aspartame; Caffeine; Carbonated Beverages; Epilepsy; Female; Humans; Hyponatremia; Middle Aged; Wate

2008
[EEG studies of cases with epileptic and intricate somatic manifestations].
    Revue neurologique, 1967, Volume: 117, Issue:1

    Topics: Adult; Asthma; Atropa belladonna; Caffeine; Child; Drug Tolerance; Eczema; Electroencephalography; E

1967
[Legalized koffinautin abuse].
    Ugeskrift for laeger, 1981, May-04, Volume: 143, Issue:19

    Topics: Caffeine; Epilepsy; Histamine H1 Antagonists; Humans; Hyperkinesis; Psychoses, Substance-Induced; Su

1981
Epileptogenic actions of xanthines in relation to their affinities for adenosine A1 receptors in CA3 neurons of hippocampal slices (guinea pig).
    Brain research, 1994, Mar-21, Volume: 640, Issue:1-2

    Topics: Adenosine; Animals; Caffeine; Calcium; Cyclic AMP; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Tech

1994
Calcium-antagonistic effects of carbamazepine in epilepsies and affective psychoses.
    Neuropsychobiology, 1993, Volume: 27, Issue:3

    Topics: Animals; Caffeine; Calcium Channel Blockers; Carbamazepine; Epilepsy; Guinea Pigs; Hippocampus; In V

1993
GABA-responses of CA3 neurones at epileptogenic threshold concentrations of convulsants.
    Neuroreport, 1993, Volume: 4, Issue:6

    Topics: Action Potentials; Animals; Bicarbonates; Bicuculline; Caffeine; Chlorides; Convulsants; Epilepsy; g

1993
Genetic variation in immediate and delayed postictal refractory period in rats.
    Brain research, 1996, May-20, Volume: 721, Issue:1-2

    Topics: Adenosine; Animals; Caffeine; Central Nervous System Stimulants; Epilepsy; Genetic Variation; Male;

1996
Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Acoustic Stimulation; Animals; Caffeine; Convulsants; Dyphylline; Elect

1997
Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: in vitro and in vivo comparison and calculation of in vivo inhibition constants.
    Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:5

    Topics: Adult; Anticonvulsants; Caffeine; Carbon Dioxide; Carbon Isotopes; Cytochrome P-450 CYP3A; Cytochrom

1997
Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test.
    British journal of clinical pharmacology, 1998, Volume: 45, Issue:2

    Topics: Adolescent; Analgesics, Non-Narcotic; Breath Tests; Caffeine; Carbamazepine; Carbon Dioxide; Central

1998
Epileptogenic action of caffeine during anoxia in the neonatal rat hippocampus.
    Annals of neurology, 1999, Volume: 46, Issue:1

    Topics: Action Potentials; Animals; Caffeine; Epilepsy; Hypoxia; Male; Neurons; Rats; Rats, Wistar; Receptor

1999
Relationship between large conductance calcium-activated potassium channel and bursting activity.
    Brain research, 2000, Mar-31, Volume: 860, Issue:1-2

    Topics: Action Potentials; Animals; Apamin; Caffeine; Calcium; Cells, Cultured; Cerebral Cortex; Epilepsy; I

2000
Influences of caffeine to nitric oxide production and zonisamide concentration in the brain of seizure-susceptible EL mice.
    Psychiatry and clinical neurosciences, 2001, Volume: 55, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Caffeine; Central Nervous System Stimulants; Drug Interactions; Epi

2001
Effect of orally administered guanosine on seizures and death induced by glutamatergic agents.
    Brain research, 2001, Sep-07, Volume: 912, Issue:2

    Topics: Animals; Brain; Caffeine; Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Elapid Venom

2001
Psychostimulants and epilepsy.
    Epilepsia, 2002, Volume: 43 Suppl 2

    Topics: Amphetamines; Caffeine; Cannabinoids; Central Nervous System Stimulants; Cocaine; Epilepsy; Hallucin

2002
[Disorders of cerebral hemodynamics and their correction in epilepsy].
    Sovetskaia meditsina, 1979, Issue:7

    Topics: Brain Ischemia; Caffeine; Cerebrovascular Circulation; Epilepsy; Humans; Papaverine; Phenobarbital

1979
[An analysis of 22 years' experience with the medicinal treatment of epilepsy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1975, Volume: 75, Issue:3

    Topics: Adult; Anticonvulsants; Bromides; Caffeine; Codeine; Drug Therapy, Combination; Epilepsy; Female; Hi

1975
Paroxysmal activity in the rabbit visual cortex induced by photostimulation.
    Biomedical science, 1991, Volume: 2, Issue:4

    Topics: Animals; Caffeine; Diazepam; Electroencephalography; Epilepsy; Pentylenetetrazole; Photic Stimulatio

1991
Caffeine-induced epileptic discharges in CA3 neurons of hippocampal slices of the guinea pig.
    Neuroscience letters, 1991, Aug-05, Volume: 129, Issue:1

    Topics: Animals; Caffeine; Calcium; Epilepsy; Flunarizine; Guinea Pigs; Hippocampus; In Vitro Techniques; Me

1991
Pregnancy-induced changes in drug metabolism in epileptic women.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:2

    Topics: Adult; Anticonvulsants; Biological Availability; Blood Proteins; Caffeine; Chromatography, High Pres

1991
[Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1990, Volume: 90, Issue:6

    Topics: Adolescent; Adult; Brain Ischemia; Caffeine; Cerebrovascular Circulation; Drug Therapy, Combination;

1990
Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Aged; Antipyrine; Caffeine; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme

1989
Comparative influence of calcium blocker and purinergic drugs on epileptiform bursting in rat hippocampal slices.
    Brain research, 1988, Feb-16, Volume: 441, Issue:1-2

    Topics: Adenosine; Animals; Caffeine; Calcium; Epilepsy; Hippocampus; In Vitro Techniques; Magnesium; Male;

1988
Modulatory action of purinergic drugs on high potassium-induced epileptiform bursting in rat hippocampal slices.
    Pharmacological research communications, 1987, Volume: 19, Issue:11

    Topics: Animals; Caffeine; Calcium; Epilepsy; Hippocampus; In Vitro Techniques; Magnesium; Male; Phenylisopr

1987
Protective effect of adenosine and nicotinamide against audiogenic seizure.
    Biochemical pharmacology, 1974, Oct-15, Volume: 23, Issue:20

    Topics: Acoustic Stimulation; Adenosine; Adenosine Triphosphate; Animals; Blood Pressure; Brain Chemistry; C

1974
[Treatment of partial epilepsies with a sultiamum containing combination].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:12

    Topics: Adolescent; Adult; Aggression; Anticonvulsants; Barbiturates; Caffeine; Child; Electroencephalograph

1969
Serum copper levels and epilepsy.
    Epilepsia, 1972, Volume: 13, Issue:5

    Topics: Acetazolamide; Adolescent; Adult; Age Factors; Amphetamine; Anticonvulsants; Caffeine; Ceruloplasmin

1972
[Treatment of epilepsy with a combination of Gardenal and caffeine. Presentation of 84 cases].
    Hospital (Rio de Janeiro, Brazil), 1968, Volume: 74, Issue:3

    Topics: Adolescent; Adult; Caffeine; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital

1968
[Treatment of epilepsy using a combination of Gardenal and caffeine. Report of 84 cases].
    Hospital (Rio de Janeiro, Brazil), 1968, Volume: 74, Issue:3

    Topics: Adolescent; Adult; Caffeine; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital

1968
[Cessation of status epilepticus and serial seizures with amytal-caffeine].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1970, Volume: 70, Issue:1

    Topics: Amobarbital; Caffeine; Epilepsy; Humans; Injections, Intravenous; Injections, Subcutaneous

1970
[Therapy of epilepsy].
    Therapeutische Umschau. Revue therapeutique, 1967, Volume: 24, Issue:12

    Topics: Amphetamine; Anticonvulsants; Caffeine; Child; Drug Synergism; Epilepsy; Humans; Hydantoins; Phenoba

1967