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caffeine and Down Syndrome

caffeine has been researched along with Down Syndrome in 8 studies

Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

Research Excerpts

ExcerptRelevanceReference
" Down syndrome (DS) lymphocytes showed twice as much constitutive DNA damage in G2 than control ones, when recording it as chromosomal aberrations in metaphase, after caffeine-induced checkpoint abrogation."3.74G2 checkpoint-dependent DNA repair and its response to catalase in Down syndrome and control lymphocyte cultures. ( de la Torre, C; Marcelain, K; Pincheira, J; Romero, P; Salazar, L, 2007)
"An increased rate of chromosome aberrations was found in all treated cultures."1.26Response of hematopoietic cell lines derived from patients with Down's syndrome and from normal individuals to mitomycin C and caffeine. ( Banerjee, A; Huang, CC; Jung, O, 1977)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19904 (50.00)18.7374
1990's3 (37.50)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
UZBEKOVA, DG1
ESAULOVA, GD1
Pincheira, J3
Romero, P1
Marcelain, K1
Salazar, L1
de la Torre, C2
Natarajan, AT1
Obe, G1
Dulout, FN1
Rodriguez, M1
Bravo, M1
Navarrete, MH2
Lopez-Saez, JF1
Parshad, RP1
Sanford, KK1
Price, FM1
Melnick, LK1
Nee, LE1
Schapiro, MB1
Tarone, RE1
Robbins, JH1
Tapia, G1
Santos, MJ1
Banerjee, A1
Jung, O1
Huang, CC1
Morris, ME1
Griener, JC1
Msall, ME1

Other Studies

8 other studies available for caffeine and Down Syndrome

ArticleYear
[ON COMBINED USE OF GLUTAMIC ACID AND CAFFEINE IN CHILDREN WITH SOME PSYCHONEUROTIC DISEASES].
    Pediatriia, 1964, Volume: 43

    Topics: Adolescent; Asthenia; Caffeine; Child; Down Syndrome; Drug Therapy; Glutamates; Glutamic Acid; Human

1964
G2 checkpoint-dependent DNA repair and its response to catalase in Down syndrome and control lymphocyte cultures.
    Cell biology international, 2007, Volume: 31, Issue:2

    Topics: Caffeine; Catalase; Cells, Cultured; Child; Child, Preschool; Chromosome Aberrations; DNA Repair; Do

2007
The effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro.
    Human genetics, 1980, Volume: 54, Issue:2

    Topics: Adult; Ataxia Telangiectasia; Caffeine; Chromosome Aberrations; Down Syndrome; Female; Humans; In Vi

1980
Defective G2 repair in Down syndrome: effect of caffeine, adenosine and niacinamide in control and X-ray irradiated lymphocytes.
    Clinical genetics, 1994, Volume: 45, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Caffeine; Child, Preschool; Chromosome Aberrations; Chromosomes,

1994
Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, May-14, Volume: 93, Issue:10

    Topics: Alzheimer Disease; Caffeine; Case-Control Studies; Cells, Cultured; Chromatids; Cytarabine; DNA; DNA

1996
Effect of vitamin E on chromosomal aberrations in lymphocytes from patients with Down's syndrome.
    Clinical genetics, 1999, Volume: 55, Issue:3

    Topics: Caffeine; Child, Preschool; Chromosome Aberrations; Down Syndrome; Female; G2 Phase; Humans; Infant;

1999
Response of hematopoietic cell lines derived from patients with Down's syndrome and from normal individuals to mitomycin C and caffeine.
    Journal of the National Cancer Institute, 1977, Volume: 59, Issue:1

    Topics: Caffeine; Cell Division; Cell Line; Chromosome Aberrations; Chromosomes; Down Syndrome; Hematopoieti

1977
N-acetylator variability in Down's syndrome: characterization with caffeine.
    Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:3

    Topics: Acetylation; Adolescent; Adult; Caffeine; Child; Chromatography, High Pressure Liquid; Down Syndrome

1989
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