caffeine and Down Syndrome
caffeine has been researched along with Down Syndrome in 8 studies
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
" Down syndrome (DS) lymphocytes showed twice as much constitutive DNA damage in G2 than control ones, when recording it as chromosomal aberrations in metaphase, after caffeine-induced checkpoint abrogation." | 3.74 | G2 checkpoint-dependent DNA repair and its response to catalase in Down syndrome and control lymphocyte cultures. ( de la Torre, C; Marcelain, K; Pincheira, J; Romero, P; Salazar, L, 2007) |
"An increased rate of chromosome aberrations was found in all treated cultures." | 1.26 | Response of hematopoietic cell lines derived from patients with Down's syndrome and from normal individuals to mitomycin C and caffeine. ( Banerjee, A; Huang, CC; Jung, O, 1977) |
Research
Studies (8)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (50.00) | 18.7374 |
1990's | 3 (37.50) | 18.2507 |
2000's | 1 (12.50) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
UZBEKOVA, DG | 1 |
ESAULOVA, GD | 1 |
Pincheira, J | 3 |
Romero, P | 1 |
Marcelain, K | 1 |
Salazar, L | 1 |
de la Torre, C | 2 |
Natarajan, AT | 1 |
Obe, G | 1 |
Dulout, FN | 1 |
Rodriguez, M | 1 |
Bravo, M | 1 |
Navarrete, MH | 2 |
Lopez-Saez, JF | 1 |
Parshad, RP | 1 |
Sanford, KK | 1 |
Price, FM | 1 |
Melnick, LK | 1 |
Nee, LE | 1 |
Schapiro, MB | 1 |
Tarone, RE | 1 |
Robbins, JH | 1 |
Tapia, G | 1 |
Santos, MJ | 1 |
Banerjee, A | 1 |
Jung, O | 1 |
Huang, CC | 1 |
Morris, ME | 1 |
Griener, JC | 1 |
Msall, ME | 1 |
Other Studies
8 other studies available for caffeine and Down Syndrome
Article | Year |
---|---|
[ON COMBINED USE OF GLUTAMIC ACID AND CAFFEINE IN CHILDREN WITH SOME PSYCHONEUROTIC DISEASES].
Topics: Adolescent; Asthenia; Caffeine; Child; Down Syndrome; Drug Therapy; Glutamates; Glutamic Acid; Human | 1964 |
G2 checkpoint-dependent DNA repair and its response to catalase in Down syndrome and control lymphocyte cultures.
Topics: Caffeine; Catalase; Cells, Cultured; Child; Child, Preschool; Chromosome Aberrations; DNA Repair; Do | 2007 |
The effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro.
Topics: Adult; Ataxia Telangiectasia; Caffeine; Chromosome Aberrations; Down Syndrome; Female; Humans; In Vi | 1980 |
Defective G2 repair in Down syndrome: effect of caffeine, adenosine and niacinamide in control and X-ray irradiated lymphocytes.
Topics: Adenosine; Adenosine Triphosphate; Caffeine; Child, Preschool; Chromosome Aberrations; Chromosomes, | 1994 |
Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture.
Topics: Alzheimer Disease; Caffeine; Case-Control Studies; Cells, Cultured; Chromatids; Cytarabine; DNA; DNA | 1996 |
Effect of vitamin E on chromosomal aberrations in lymphocytes from patients with Down's syndrome.
Topics: Caffeine; Child, Preschool; Chromosome Aberrations; Down Syndrome; Female; G2 Phase; Humans; Infant; | 1999 |
Response of hematopoietic cell lines derived from patients with Down's syndrome and from normal individuals to mitomycin C and caffeine.
Topics: Caffeine; Cell Division; Cell Line; Chromosome Aberrations; Chromosomes; Down Syndrome; Hematopoieti | 1977 |
N-acetylator variability in Down's syndrome: characterization with caffeine.
Topics: Acetylation; Adolescent; Adult; Caffeine; Child; Chromatography, High Pressure Liquid; Down Syndrome | 1989 |