caffeine and Diabetes Mellitus studies

Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Research Excerpts

Excerpt	Relevance	Reference
"Caffeine may increase an individual's sensitivity to hypoglycemia through the combined effects of reducing substrate delivery to the brain via constriction of the cerebral arteries, whilst simultaneously increasing brain glucose metabolism and augmenting catecholamine production."	6.40	The best defense against hypoglycemia is to recognize it: is caffeine useful? ( Kerr, D; Watson, J, 1999)
"Caffeine ingestion negatively affects insulin sensitivity during an oral glucose tolerance test (OGTT) in lean and obese men, but this has not been studied in individuals with type 2 diabetes."	5.11	Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes. ( Battram, DS; Graham, TE; McLaren, DH; Robinson, LE; Sathasivam, P; Savani, S, 2004)
" These beverages include compounds that may have contradictory effects on insulin and glucose: Caffeine impairs insulin sensitivity, but polyphenolic molecules within tea, coffee, and cocoa augment the effects of insulin."	4.98	The Potential Effects of Caffeinated Beverages on Insulin Sensitivity. ( Buslach, N; Cherniack, EP; Lee, HF, 2018)
" However, caffeine at high doses can increase anxiety, insomnia, calcium loss and possibly the risk of fractures."	4.89	Coffee and tea: perks for health and longevity? ( Bhatti, SK; Lavie, CJ; O'Keefe, JH, 2013)
"To evaluate, in compliant patients, the pharmaceutical costs of treating obesity with fenfluramine/mazindol, fenfluramine/phentermine, caffeine/ephedrine, or mazindol relative to the pharmaceutical costs of treating obesity-related comorbid conditions and reducing cardiovascular risk."	3.70	Pharmaceutical cost savings of treating obesity with weight loss medications. ( Bray, GA; Greenway, FL; Rood, JC; Ryan, DH; Smith, SR; Tucker, EW, 1999)
"Caffeine may increase an individual's sensitivity to hypoglycemia through the combined effects of reducing substrate delivery to the brain via constriction of the cerebral arteries, whilst simultaneously increasing brain glucose metabolism and augmenting catecholamine production."	2.40	The best defense against hypoglycemia is to recognize it: is caffeine useful? ( Kerr, D; Watson, J, 1999)
"Obesity is an important risk factor for diabetes mellitus (DM) which is a major global health problem."	1.72	Effects of Isoprenaline on ventricular myocyte shortening and Ca ( Howarth, FC; Qureshi, MA; Sultan, A, 2022)
"Ursolic acid (1) was identified as the responsible for the activity of maté and guayusa extracts in the activation of TGR5, a nuclear receptor of relevance for the prevention and management of diabetes and metabolic syndrome because of its involvement in the regulation of energy expenditure and insulin sensitivity."	1.51	Bioactive triterpenoids from the caffeine-rich plants guayusa and maté. ( Appendino, G; Chianese, G; Collado, JA; Golin-Pacheco, SD; Munoz, E; Pollastro, F; Taglialatela-Scafati, O, 2019)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (34.88)	18.7374
1990's	2 (4.65)	18.2507
2000's	9 (20.93)	29.6817
2010's	13 (30.23)	24.3611
2020's	4 (9.30)	2.80

Authors	Studies
Ekstrom, JL	1
Pauly, TA	1
Carty, MD	1
Soeller, WC	1
Culp, J	1
Danley, DE	1
Hoover, DJ	1
Treadway, JL	1
Gibbs, EM	1
Fletterick, RJ	1
Day, YS	1
Myszka, DG	1
Rath, VL	1
Saimaiti, A	1
Zhou, DD	1
Li, J	1
Xiong, RG	1
Gan, RY	1
Huang, SY	1
Shang, A	1
Zhao, CN	1
Li, HY	1
Li, HB	1
Sultan, A	1
Qureshi, MA	1
Howarth, FC	1
Zhang, G	1
Sun, X	1
Yuan, T	1
Guo, C	1
Zhou, Z	1
Wang, L	1
Dou, G	1
Srivastava, B	1
Sen, S	1
Sen, K	1
Fu, QY	1
Li, QS	1
Lin, XM	1
Qiao, RY	1
Yang, R	1
Li, XM	1
Dong, ZB	1
Xiang, LP	1
Zheng, XQ	1
Lu, JL	1
Yuan, CB	1
Ye, JH	1
Liang, YR	1
Dewar, L	1
Heuberger, R	1
Cherniack, EP	1
Buslach, N	1
Lee, HF	1
Kromhout, MA	1
van Eijk, M	1
Pieper, MJC	1
Chel, VGM	1
Achterberg, WP	1
Numans, ME	1
Torres-Collado, L	1
García-de la Hera, M	1
Navarrete-Muñoz, EM	1
Compañ-Gabucio, LM	1
Gonzalez-Palacios, S	1
Vioque, J	1
Chianese, G	1
Golin-Pacheco, SD	1
Taglialatela-Scafati, O	1
Collado, JA	1
Munoz, E	1
Appendino, G	1
Pollastro, F	1
Inoue, M	1
Tsugane, S	1
Bhatti, SK	1
O'Keefe, JH	1
Lavie, CJ	1
Kim, J	2
Shim, J	1
Lee, CY	1
Lee, KW	1
Lee, HJ	1
Wise, LA	1
Laughlin-Tommaso, SK	1
Oba, S	1
Nagata, C	1
Nakamura, K	1
Fujii, K	1
Kawachi, T	1
Takatsuka, N	1
Shimizu, H	1
Mineharu, Y	1
Koizumi, A	1
Wada, Y	1
Iso, H	1
Watanabe, Y	1
Date, C	1
Yamamoto, A	1
Kikuchi, S	1
Inaba, Y	1
Toyoshima, H	1
Kondo, T	1
Tamakoshi, A	1
Gosselin, C	1
Haman, F	1
Mokelke, EA	1
Wang, M	1
Sturek, M	1
FENNELLY, JJ	1
LASKER, N	1
SAPELKINA, LV	1
Mukamal, KJ	1
Maclure, M	1
Muller, JE	1
Sherwood, JB	1
Mittleman, MA	1
Robinson, LE	1
Savani, S	1
Battram, DS	1
McLaren, DH	1
Sathasivam, P	1
Graham, TE	1
Kerr, D	2
Everett, J	1
Greenberg, JA	1
Boozer, CN	1
Geliebter, A	1
Daly, JW	1
Cobbs, LW	1
Greenway, FL	1
Ryan, DH	1
Bray, GA	1
Rood, JC	1
Tucker, EW	1
Smith, SR	1
Yamato, T	1
Yamasaki, S	1
Misumi, Y	1
Kino, M	1
Obata, T	1
Aomine, M	1
Watson, J	1
Tofovic, SP	1
Kost, CK	1
Jackson, EK	1
Bastacky, SI	1
Heyden, S	3
Studlar, M	3
Pichler, O	2
Ammon, HP	1
Kaufmann, RL	1
Steinke, J	1
Kahn, CB	1
Soeldner, JS	1
Haslbeck, M	1
Mehnert, H	1
Siedek, H	1
Hammerl, H	1
Henk, W	1
Köhn, H	1
Kränzl, C	1
Escher, M	1
Pisano, L	1
Marozzi, G	1
Cecchi, D	1
Manca, S	1
Masala, M	1
Guy-Grand, B	1
Dorf, G	1
Duchier, J	1
Aimez, P	1
Alberti, KG	1
Hockaday, TD	1
Williamson, DH	1
Junod, A	1
Letarte, J	1
Lambert, AE	1
Stauffacher, W	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
[NCT00005243]				0 participants	Observational	1989-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Dietary sources, health benefits, and risks of caffeine. Critical reviews in food science and nutrition, 2023, Volume: 63, Issue:29 Topics: Adolescent; Caffeine; Child; Diabetes Mellitus; Diet; Female; Humans; Migraine Disorders; Obesity; P	2023
Antidiabetic Effects of Tea. Molecules (Basel, Switzerland), 2017, May-20, Volume: 22, Issue:5 Topics: Animals; Caffeine; Camellia sinensis; Catechin; Diabetes Mellitus; Diabetes Mellitus, Experimental;	2017
The effect of acute caffeine intake on insulin sensitivity and glycemic control in people with diabetes. Diabetes & metabolic syndrome, 2017, Volume: 11 Suppl 2 Topics: Adult; Blood Glucose; Caffeine; Diabetes Mellitus; Female; Humans; Insulin Resistance; Male; Middle	2017
The Potential Effects of Caffeinated Beverages on Insulin Sensitivity. Journal of the American College of Nutrition, 2018, Volume: 37, Issue:2 Topics: Animals; Beverages; Blood Glucose; Cacao; Caffeine; Chocolate; Coffee; Diabetes Mellitus; Diet; Food	2018
Coffee Drinking and Reduced Risk of Liver Cancer: Update on Epidemiological Findings and Potential Mechanisms. Current nutrition reports, 2019, Volume: 8, Issue:3 Topics: Antioxidants; Caffeine; Cardiovascular Diseases; Chlorogenic Acid; Coffee; Diabetes Mellitus; Drinki	2019
Coffee and tea: perks for health and longevity? Current opinion in clinical nutrition and metabolic care, 2013, Volume: 16, Issue:6 Topics: Antioxidants; Anxiety; Blood Glucose; Blood Pressure; Caffeine; Calcium; Cardiovascular Diseases; Co	2013
Cocoa phytochemicals: recent advances in molecular mechanisms on health. Critical reviews in food science and nutrition, 2014, Volume: 54, Issue:11 Topics: Animals; Biological Availability; Cacao; Caffeine; Cardiovascular Diseases; Diabetes Mellitus; Flavo	2014
Epidemiology of Uterine Fibroids: From Menarche to Menopause. Clinical obstetrics and gynecology, 2016, Volume: 59, Issue:1 Topics: Age Distribution; Age Factors; Alcohol Drinking; Black People; Caffeine; Diabetes Mellitus; Diet; Fe	2016
Coffee, diabetes, and weight control. The American journal of clinical nutrition, 2006, Volume: 84, Issue:4 Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Caffeine; Coffee; Diabetes Mellitus; Epidemiolo	2006
Caffeine analogs: biomedical impact. Cellular and molecular life sciences : CMLS, 2007, Volume: 64, Issue:16 Topics: Alzheimer Disease; Asthma; Biomedical Research; Caffeine; Calcium; Central Nervous System Stimulants	2007
The best defense against hypoglycemia is to recognize it: is caffeine useful? Diabetes technology & therapeutics, 1999,Summer, Volume: 1, Issue:2 Topics: Adult; Awareness; Blood Glucose; Caffeine; Diabetes Mellitus; Diabetes Mellitus, Type 1; Food Analys	1999
[Coffee-drinking from the medical point of view]. Schweizerische medizinische Wochenschrift, 1973, Volume: 103, Issue:43 Topics: Adult; Blood Pressure; Caffeine; Coffee; Diabetes Mellitus; Feeding Behavior; Female; Gout; Health S	1973
[The effect of caffeine on the metabolism of lipids and carbohydrates]. Zeitschrift fur Ernahrungswissenschaft, 1973, Volume: 12, Issue:2 Topics: Adenosine Monophosphate; Adipose Tissue; Adult; Animals; Arteriosclerosis; Blood Glucose; Caffeine;	1973

Article	Year
Effects of green tea extracts on non-shivering thermogenesis during mild cold exposure in young men. The British journal of nutrition, 2013, Jul-28, Volume: 110, Issue:2 Topics: Adult; Area Under Curve; Caffeine; Camellia sinensis; Catechin; Cold Temperature; Diabetes Mellitus;	2013
Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes. The Journal of nutrition, 2004, Volume: 134, Issue:10 Topics: Adult; Area Under Curve; Blood Glucose; Caffeine; Diabetes Mellitus; Diabetes Mellitus, Type 2; Doub	2004

caffeine and Diabetes Mellitus

Research Excerpts

Research

Studies (43)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. Chemistry & biology, 2002, Volume: 9, Issue:8 Topics: Allosteric Site; Binding Sites; Crystallography, X-Ray; Diabetes Mellitus; Drug Evaluation, Preclini	2002
Effects of Isoprenaline on ventricular myocyte shortening and Ca European journal of pharmacology, 2022, Oct-15, Volume: 933 Topics: Animals; Caffeine; Diabetes Mellitus; Diabetes Mellitus, Type 2; Isoproterenol; Myocytes, Cardiac; O	2022
Certain Dietary Nutrients Reduce the Risk of Eye Affliction/Retinopathy in Individuals with Diabetes: National Health and Nutrition Examination Survey, 2003-2018. International journal of environmental research and public health, 2022, 09-26, Volume: 19, Issue:19 Topics: Caffeine; Carotenoids; Cholesterol, Dietary; Copper; Diabetes Mellitus; Diabetic Retinopathy; Diet;	2022
Free serum sorbitol and its interaction with caffeine: A suggestive approach for plausible remediation of diabetic neuropathy. Biotechnology and applied biochemistry, 2022, Volume: 69, Issue:1 Topics: Caffeine; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Humans; Sorbitol; Spectr	2022
BeCaf study: caffeine and behaviour in nursing homes, a study protocol and EBM training program. The Netherlands journal of medicine, 2018, Volume: 76, Issue:3 Topics: Aged; Caffeine; Clinical Protocols; Cohort Studies; Curriculum; Dementia; Diabetes Mellitus; Educati	2018
Coffee Drinking and Associated Factors in an Elderly Population in Spain. International journal of environmental research and public health, 2018, 08-06, Volume: 15, Issue:8 Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alcohol Drinking; Caffeine; Coffee; Diabetes Me	2018
Bioactive triterpenoids from the caffeine-rich plants guayusa and maté. Food research international (Ottawa, Ont.), 2019, Volume: 115 Topics: Caffeine; Diabetes Mellitus; Ilex guayusa; Ilex paraguariensis; Insulin Resistance; Metabolic Syndro	2019
Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women. The British journal of nutrition, 2010, Volume: 103, Issue:3 Topics: Alcohol Drinking; Body Mass Index; Cacao; Caffeine; Coffee; Cohort Studies; Diabetes Mellitus; Educa	2010
Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women. Journal of epidemiology and community health, 2011, Volume: 65, Issue:3 Topics: Adult; Age Distribution; Aged; Alcohol Drinking; Beverages; Caffeine; Cardiovascular Diseases; Coffe	2011
Exercise training enhances coronary smooth muscle cell sodium-calcium exchange activity in diabetic dyslipidemic Yucatan swine. Annals of the New York Academy of Sciences, 2002, Volume: 976 Topics: Animals; Caffeine; Cholesterol, Dietary; Coronary Vessels; Diabetes Mellitus; Dietary Fats; Disease	2002
ACUTE RENAL FAILURE FOLLOWING ACETOPHENETIDIN INGESTION. The Journal of the Medical Society of New Jersey, 1964, Volume: 61 Topics: Acidosis; Acute Kidney Injury; Aspirin; Caffeine; Diabetes Mellitus; Diabetic Ketoacidosis; Diagnosi	1964
[GASTRIC SECRETION IN CHILDREN WITH DIABETES MELLITUS]. Voprosy okhrany materinstva i detstva, 1964, Volume: 9 Topics: Adolescent; Caffeine; Child; Diabetes Mellitus; Diabetes Mellitus, Type 1; Digestion; Gastric Acidit	1964
Caffeinated coffee consumption and mortality after acute myocardial infarction. American heart journal, 2004, Volume: 147, Issue:6 Topics: Aged; Alcohol Drinking; Caffeine; Carbonated Beverages; Coffee; Cohort Studies; Comorbidity; Diabete	2004
Coffee, diabetes and insulin sensitivity. Diabetologia, 2005, Volume: 48, Issue:7 Topics: Adult; Blood Glucose; Caffeine; Coffee; Diabetes Mellitus; Diabetes Mellitus, Type 1; Humans; Hyperg	2005
Lethargy, anxiety, and impotence in a diabetic. Hospital practice (Office ed.), 1982, Volume: 17, Issue:8 Topics: Adult; Anxiety; Caffeine; Diabetes Complications; Diabetes Mellitus; Erectile Dysfunction; Humans; H	1982
Pharmaceutical cost savings of treating obesity with weight loss medications. Obesity research, 1999, Volume: 7, Issue:6 Topics: Adolescent; Adult; Appetite Depressants; Caffeine; Cardiovascular Diseases; Diabetes Mellitus; Drug	1999
Postrest contraction in the ventricular papillary muscle of spontaneously diabetic WBN/Kob rat. Experimental animals, 2001, Volume: 50, Issue:1 Topics: Animals; Blood Glucose; Body Weight; Caffeine; Calcium; Diabetes Mellitus; Electric Stimulation; Mal	2001
Long-term caffeine consumption exacerbates renal failure in obese, diabetic, ZSF1 (fa-fa(cp)) rats. Kidney international, 2002, Volume: 61, Issue:4 Topics: Animals; Caffeine; Diabetes Mellitus; Diabetic Nephropathies; Drug Administration Schedule; Glomerul	2002
[Is there a contraindication for coffee? Comment on the article by H. Klinge: Ther d. Gegenw. 115 (1976), 805-12]. Therapie der Gegenwart, 1977, Volume: 116, Issue:5 Topics: Adult; Aged; Caffeine; Coffee; Diabetes Mellitus; Gastrointestinal Diseases; Humans; Hypertension; L	1977
[Metabolism studies with coffee and caffeine in healthy subjects, diabetics and patients with liver disease]. Zeitschrift fur Ernahrungswissenschaft, 1976, Volume: 15, Issue:1 Topics: Caffeine; Coffee; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucose; Humans; Insulin; Liver Dis	1976
[The effect of caffeine on the serum insulin level during intravenous glucose tolerance test in patients with chemical diabetes]. Zeitschrift fur Ernahrungswissenschaft, 1976, Volume: 15, Issue:2 Topics: Adult; Aged; Blood Glucose; Caffeine; Diabetes Mellitus; Glucose Tolerance Test; Humans; Insulin; Ma	1976
[Diabetes mellitus and coffee]. Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa, 1972, Volume: 14 Topics: Blood Glucose; Caffeine; Catecholamines; Coffee; Cyclic AMP; Diabetes Mellitus; Diet Therapy; Drinki	1972
[Effects of coffee during good health and in disease from the medical standpoint]. Minerva medica, 1974, Jan-17, Volume: 65, Issue:3 Topics: Acute Disease; Aged; Blood Pressure; Caffeine; Cerebrovascular Disorders; Coffee; Diabetes Mellitus;	1974
[Daily profile of metabolites of carbohydrate and fat metabolism, and of immune-reactive insulin during caffeine administration]. Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa, 1972, Volume: 14 Topics: Blood Glucose; Caffeine; Circadian Rhythm; Diabetes Mellitus; Fatty Acids, Nonesterified; Glycerol;	1972
[Effects of coffee administration on glucose tolerance in a group of diabetic subjects]. Minerva medica, 1972, Sep-05, Volume: 63, Issue:61 Topics: Blood Glucose; Caffeine; Carbohydrate Metabolism; Coffee; Diabetes Mellitus; Glucose Tolerance Test;	1972
[Dietetics and nutrition in 1972]. La Revue du praticien, 1972, Feb-21, Volume: 22, Issue:6 Topics: Adipose Tissue; Alcoholic Intoxication; Anorexia Nervosa; Caffeine; Calcium; Catecholamines; Coffee;	1972
Metabolic effects of chronic caffeine administration in a patient with diabetes mellitus. Proceedings of the Royal Society of Medicine, 1972, Volume: 65, Issue:5 Topics: Caffeine; Diabetes Mellitus; Fatty Acids, Nonesterified; Humans; Hyperglycemia; Ketone Bodies; Male;	1972
Studies in spiny mice (Acomys cahirinus): metabolic state and pancreatic insulin release in vitro. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1969, Volume: 1, Issue:2 Topics: Age Factors; Animals; Antigens; Arginine; Blood Glucose; Caffeine; Calcium; Diabetes Mellitus; Gluca	1969