caffeine has been researched along with Depression in 85 studies
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to systematically review and analyze results from observational studies on coffee, caffeine, and tea consumption and association or risk of depression." | 8.93 | Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies. ( Castellano, S; Galvano, F; Grosso, G; Micek, A; Pajak, A, 2016) |
| "Coffee and caffeine consumption were significantly associated with decreased risk of depression." | 8.93 | Coffee and caffeine consumption and depression: A meta-analysis of observational studies. ( Shen, X; Wang, L; Wu, Y; Zhang, D, 2016) |
| "Among US adults, early morning caffeine consumers had a lower prevalence of depression than non-consumers; caffeine intake during non-early morning periods is associated with a high prevalence of depression." | 8.31 | Does the timing of intake matter? Association between caffeine intake and depression: Evidence from the National Health and Nutrition Examination Survey. ( Ding, Y; Gong, R; Liu, Y; Xu, F; Yang, J; Yin, J; Zhao, L, 2023) |
| "Our study suggests that black tea consumption up to 4 cups and caffeine intake between 450-600 mg can help protect against depression." | 8.02 | Effects of black tea consumption and caffeine intake on depression risk in black tea consumers. ( Asil, E; Yardimci, H; Yılmaz, MV, 2021) |
| "Exercise prevents depression through peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α)-mediated activation of a particular branch of the kynurenine pathway." | 8.02 | Caffeine protects against stress-induced murine depression through activation of PPARγC1α-mediated restoration of the kynurenine pathway in the skeletal muscle. ( Cai, X; Deng, B; Du, X; Fang, C; Hayashi, S; Ishido, S; Sheng, J; Tsutsui, H; Zheng, H, 2021) |
| "An increase in brain oxido-nitrosative stress and anxiety-like behavior was observed in caffeine treated mice." | 7.91 | Lacidipine attenuates caffeine-induced anxiety-like symptoms in mice: Role of calcium-induced oxido-nitrosative stress. ( Bansal, N; Khurana, K, 2019) |
| "Adenosine and its analogues have been shown to induce "behavioral despair" in animal models believed to be relevant to depression." | 7.72 | Adenosine A2A receptors and depression. ( Costentin, J; El Yacoubi, M; Vaugeois, JM, 2003) |
| "Caffeine consumption has been increasing rapidly in adolescents; however, most research on the behavioral effects of caffeine has been conducted in adults." | 5.43 | Chronic caffeine produces sexually dimorphic effects on amphetamine-induced behavior, anxiety and depressive-like behavior in adolescent rats. ( Dixon, RS; Hickman, ET; Lee, SM; Townsend, SE; Turgeon, SM, 2016) |
| "Clinical depression was defined as self-reported physician-diagnosed depression and antidepressant use." | 5.37 | Coffee, caffeine, and risk of depression among women. ( Ascherio, A; Koenen, K; Lucas, M; Mirzaei, F; O'Reilly, ÉJ; Okereke, OI; Pan, A; Willett, WC, 2011) |
| "Depression was positively related to caffeine use for both cohorts, though mediated by caffeine withdrawal effects." | 5.35 | Mountain Dew or mountain don't?: a pilot investigation of caffeine use parameters and relations to depression and anxiety symptoms in 5th- and 10th-grade students. ( Bell, DJ; Luebbe, AM, 2009) |
| "Caffeine was injected at doses of 80 mg/kg daily for five days." | 5.29 | 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. ( Haleem, DJ; Haleem, MA; Yasmeen, A; Zafar, A, 1995) |
| "When administered to normal healthy patients, a nonselective adenosine A1/A2A antagonist, caffeine, tended to improve anxiety and depression at low doses and to exacerbate anxiety at high doses." | 4.90 | Involvement of adenosine A2A receptors in depression and anxiety. ( Kanda, T; Kobayashi, M; Yamada, K, 2014) |
| " This report reviews the current literature on sleep patterns in adolescents, factors contributing to chronic sleep loss (ie, electronic media use, caffeine consumption), and health-related consequences, such as depression, increased obesity risk, and higher rates of drowsy driving accidents." | 4.90 | Insufficient sleep in adolescents and young adults: an update on causes and consequences. ( Owens, J, 2014) |
| "Chronic, heavy caffeine ingestion may cause or exacerbate anxiety and may be associated with depression and increased use of antianxiety drugs." | 4.77 | Psychotropic effects of caffeine. ( Clementz, GL; Dailey, JW, 1988) |
| "Among US adults, early morning caffeine consumers had a lower prevalence of depression than non-consumers; caffeine intake during non-early morning periods is associated with a high prevalence of depression." | 4.31 | Does the timing of intake matter? Association between caffeine intake and depression: Evidence from the National Health and Nutrition Examination Survey. ( Ding, Y; Gong, R; Liu, Y; Xu, F; Yang, J; Yin, J; Zhao, L, 2023) |
| " Intakes of coffee, green tea, and caffeine, as well as depressive symptoms, were assessed with a validated brief dietary history questionnaire (BDHQ) and the Center for Epidemiologic Studies Depression Scale (CES-D), respectively." | 3.96 | Intake of Coffee Associated With Decreased Depressive Symptoms Among Elderly Japanese Women: A Multi-Center Cross-Sectional Study. ( Kimura, Y; Kobayashi, S; Sasaki, S; Suga, H, 2020) |
| "An increase in brain oxido-nitrosative stress and anxiety-like behavior was observed in caffeine treated mice." | 3.91 | Lacidipine attenuates caffeine-induced anxiety-like symptoms in mice: Role of calcium-induced oxido-nitrosative stress. ( Bansal, N; Khurana, K, 2019) |
| " The relationship between caffeine intake and suicidal ideation was analyzed by obtaining odds ratios with multivariate logistic regression in which depression and sleep problems were adjusted for age." | 3.91 | Relationship between daily coffee intake and suicidal ideation. ( Lee, K; Park, H; Suh, BS, 2019) |
| "Results suggest that higher consumption of green tea, coffee and caffeine may confer protection against depression." | 3.80 | Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population. ( Hayabuchi, H; Kume, A; Kurotani, K; Kuwahara, K; Mizoue, T; Nanri, A; Pham, NM; Sato, M, 2014) |
| "We found no evidence that reduced risk of cognitive decline in women with high caffeine consumption is moderated or confounded by diabetes or depression." | 3.80 | The association between caffeine and cognitive decline: examining alternative causal hypotheses. ( Amieva, H; Ancelin, ML; Carrière, I; Ritchie, K; Rouaud, O, 2014) |
| "Adenosine and its analogues have been shown to induce "behavioral despair" in animal models believed to be relevant to depression." | 3.72 | Adenosine A2A receptors and depression. ( Costentin, J; El Yacoubi, M; Vaugeois, JM, 2003) |
| " longiflorus (CLE) was investigated for sedative, anticonvulsant and behaviour modifying activity using thiopental sleeping, caffeine induced convulsion and forced swimming depression tests." | 3.71 | Sedative, anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam. ( Büyükokuroğlu, ME; Demirezer, LO; Güvenalp, Z, 2002) |
| "By the example of two case reports, typical signs of caffeine withdrawal like headache, increased irritability, decreased performance and disturbed concentration are described." | 3.69 | [Episodic headache, diminished performance and depressive mood]. ( Cacciatore, R; Helbling, A; Hess, B; Jost, C, 1996) |
| "The authors explored the relationship between ad lib caffeine consumption in college students and the incidence of caffeinism, characterized by heightened anxiety, depression, and various psychophysiological reactions." | 3.66 | Ad lib caffeine consumption, symptoms of caffeinism, and academic performance. ( Andress, D; Gilliland, K, 1981) |
| "Among 83 hospitalized adult psychiatric patients, 22% reported being high caffeine consumers (750 mg or more per day); these patients scored significantly greater on the State-Trait Anxiety Index and the Beck Depression Scale than moderate and low consumers." | 3.66 | Anxiety and depression associated with caffeinism among psychiatric inpatients. ( Chamberlin, K; Fontaine, P; Greden, JF; Lubetsky, M, 1978) |
| "This clinical study of 62 patients with restless legs syndrome and associated anxious-depressed and other clinical states seems to indicate that caffeine is the major etiological factor in the causation of the restless legs syndrome." | 3.66 | Restless legs, anxiety and caffeinism. ( Lutz, EG, 1978) |
| " Plasma level determinations after 2 and 6 weeks of treatment revealed that moderately significant correlations existed between AT plasma levels and clinical improvement, dosage intake, age, weight, sex, and coffee intake." | 2.65 | Tricyclic plasma levels in depressed outpatients treated with amitriptyline. ( Case, G; Hucker, H; Rickels, K; Weise, C, 1983) |
| "Caffeine can cause anxiety symptoms in normal individuals, especially in vulnerable patients, like those with pre-existing anxiety disorders." | 2.42 | Caffeine and psychiatric symptoms: a review. ( Benjamin, AB; Broderick, P, 2004) |
| "Generalized anxiety disorder and major depressive disorder often benefit from medication and psychotherapy." | 1.91 | Relationship between Baseline Physical Activity and Generalized Anxiety Disorder and Major Depressive Disorder Treatment Outcomes. ( Benitah Bulbarelli, EM; Chauhan, M; Clapp, AD; Ismaeel, O; Niazi, SK; Nishi, LM; Pujalte, GGA; Shahsamand, A; Yazeji, J, 2023) |
| "Depression and cancer are both prevalent diseases worldwide." | 1.91 | Caffeine intake is associated with less severe depressive symptoms in noncancer populations: an analysis based on NHANES 2007-2016. ( Dong, ZR; Li, T; Tan, SY; Wang, DX; Yan, LJ; Yan, YC; Yang, LS; Zhang, ZY, 2023) |
| "Caffeine has been known to combat stress-evoked depression." | 1.56 | New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation. ( He, RR; Kurihara, H; Li, WX; Li, YF; Luo, Z; Mao, ZF; Ouyang, SH; Tu, LF; Wang, GE; Wu, YP; Zhang, QY, 2020) |
| "Caffeine-treated adolescent male rats were exposed to caffeine (0." | 1.56 | Pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat. ( Abdulzahir, A; Hwang, K; Sanford, J; Turgeon, SM, 2020) |
| " Here we investigated the effects of chronic administration of caffeine (5mg/kg, twice daily for 14days) and its withdrawal on day 15th on the activity of per se ineffective doses of fluoxetine (5mg/kg) and escitalopram (2mg/kg) given on day 15th." | 1.46 | Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt, Slc6a15 and Adora1 gene expression. ( Doboszewska, U; Dudka, J; Herbet, M; Kanadys, A; Korga, A; Ostrowska, M; Poleszak, E; Serefko, A; Świąder, K; Szopa, A; Terlecka, J; Wlaź, A; Wlaź, P; Wośko, S; Wróbel, A; Wyska, E, 2017) |
| "Caffeine consumption has been increasing rapidly in adolescents; however, most research on the behavioral effects of caffeine has been conducted in adults." | 1.43 | Chronic caffeine produces sexually dimorphic effects on amphetamine-induced behavior, anxiety and depressive-like behavior in adolescent rats. ( Dixon, RS; Hickman, ET; Lee, SM; Townsend, SE; Turgeon, SM, 2016) |
| "Sensation seeking, depression, and substance use were all higher among energy drink users relative to non-users, and in higher frequency users relative to lower frequency users." | 1.40 | An emerging adolescent health risk: caffeinated energy drink consumption patterns among high school students. ( Asbridge, M; Azagba, S; Langille, D, 2014) |
| "Withdrawal of caffeine however produced memory deficits and significantly increases the immobility time of rats in FST." | 1.38 | Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats. ( Haider, S; Haleem, DJ; Khaliq, S; Naqvi, F; Perveen, T; Saleem, S, 2012) |
| "Clinical depression was defined as self-reported physician-diagnosed depression and antidepressant use." | 1.37 | Coffee, caffeine, and risk of depression among women. ( Ascherio, A; Koenen, K; Lucas, M; Mirzaei, F; O'Reilly, ÉJ; Okereke, OI; Pan, A; Willett, WC, 2011) |
| "Depression was measured using the CES-D (Center for Epidemiologic Studies Depression Scale) and HAM-D-3 (modified Hamilton Depression Rating Scale)." | 1.36 | Sleep debt and depression in female college students. ( Gleason, R; Kawasaki, S; Koff, E; Natarajan, V; Pavlova, M; Regestein, Q, 2010) |
| "Caffeine was injected at doses of 80 mg/kg daily for five days." | 1.29 | 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. ( Haleem, DJ; Haleem, MA; Yasmeen, A; Zafar, A, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (14.12) | 18.7374 |
| 1990's | 7 (8.24) | 18.2507 |
| 2000's | 17 (20.00) | 29.6817 |
| 2010's | 37 (43.53) | 24.3611 |
| 2020's | 12 (14.12) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, W | 1 |
| Wang, H | 1 |
| Li, X | 1 |
| Xu, Y | 1 |
| Zhang, J | 1 |
| Wang, W | 1 |
| Gong, Q | 1 |
| Qiu, X | 1 |
| Zhu, J | 1 |
| Mao, F | 1 |
| Zhang, H | 1 |
| Li, J | 1 |
| Asil, E | 1 |
| Yılmaz, MV | 1 |
| Yardimci, H | 1 |
| Albrecht, JN | 1 |
| Werner, H | 1 |
| Rieger, N | 1 |
| Widmer, N | 1 |
| Janisch, D | 1 |
| Huber, R | 1 |
| Jenni, OG | 1 |
| Markova, EV | 1 |
| Knyazheva, MA | 1 |
| Tikhonova, MA | 1 |
| Amstislavskaya, TG | 1 |
| Yang, LS | 1 |
| Zhang, ZY | 1 |
| Yan, LJ | 1 |
| Yan, YC | 1 |
| Tan, SY | 1 |
| Wang, DX | 1 |
| Dong, ZR | 1 |
| Li, T | 1 |
| Yin, J | 1 |
| Ding, Y | 1 |
| Xu, F | 1 |
| Zhao, L | 1 |
| Gong, R | 1 |
| Yang, J | 1 |
| Liu, Y | 1 |
| Clapp, AD | 1 |
| Pujalte, GGA | 1 |
| Nishi, LM | 1 |
| Benitah Bulbarelli, EM | 1 |
| Yazeji, J | 1 |
| Shahsamand, A | 1 |
| Niazi, SK | 1 |
| Ismaeel, O | 1 |
| Chauhan, M | 1 |
| Khurana, K | 1 |
| Bansal, N | 1 |
| Machado, DG | 1 |
| Lara, MVS | 1 |
| Dobler, PB | 1 |
| Almeida, RF | 1 |
| Porciúncula, LO | 1 |
| Yamazaki, R | 1 |
| Kito, S | 1 |
| Matsuda, Y | 1 |
| Shigeta, M | 1 |
| Mao, ZF | 1 |
| Ouyang, SH | 1 |
| Zhang, QY | 1 |
| Wu, YP | 1 |
| Wang, GE | 1 |
| Tu, LF | 1 |
| Luo, Z | 1 |
| Li, WX | 1 |
| Kurihara, H | 1 |
| Li, YF | 1 |
| He, RR | 1 |
| Turgeon, SM | 3 |
| Abdulzahir, A | 1 |
| Hwang, K | 1 |
| Sanford, J | 1 |
| Fang, C | 1 |
| Hayashi, S | 1 |
| Du, X | 1 |
| Cai, X | 1 |
| Deng, B | 1 |
| Zheng, H | 1 |
| Ishido, S | 1 |
| Tsutsui, H | 1 |
| Sheng, J | 1 |
| Dickinson, DL | 1 |
| Drummond, SP | 1 |
| McElroy, T | 1 |
| Szopa, A | 3 |
| Doboszewska, U | 1 |
| Herbet, M | 1 |
| Wośko, S | 3 |
| Wyska, E | 2 |
| Świąder, K | 1 |
| Serefko, A | 3 |
| Korga, A | 1 |
| Wlaź, A | 3 |
| Wróbel, A | 2 |
| Ostrowska, M | 1 |
| Terlecka, J | 1 |
| Kanadys, A | 1 |
| Poleszak, E | 3 |
| Dudka, J | 1 |
| Wlaź, P | 3 |
| Smith, AP | 2 |
| Richards, G | 2 |
| Navarro, AM | 1 |
| Abasheva, D | 1 |
| Martínez-González, MÁ | 1 |
| Ruiz-Estigarribia, L | 1 |
| Martín-Calvo, N | 1 |
| Sánchez-Villegas, A | 1 |
| Toledo, E | 1 |
| Pereira-Morales, AJ | 1 |
| Casiraghi, LP | 1 |
| Adan, A | 1 |
| Camargo, A | 1 |
| Das-Friebel, A | 1 |
| Perkinson-Gloor, N | 1 |
| Brand, S | 1 |
| Dewald-Kaufmann, JF | 1 |
| Grob, A | 1 |
| Wolke, D | 1 |
| Lemola, S | 1 |
| Gilbert, N | 1 |
| Iranpour, S | 1 |
| Sabour, S | 1 |
| Nelson, ST | 1 |
| Hsiao, L | 1 |
| Hinton, DJ | 1 |
| Andres-Beck, LG | 1 |
| Nett, KE | 1 |
| Oliveros, A | 1 |
| Choi, S | 1 |
| Veldic, M | 1 |
| Choi, DS | 1 |
| Kimura, Y | 1 |
| Suga, H | 1 |
| Kobayashi, S | 1 |
| Sasaki, S | 1 |
| Park, H | 1 |
| Suh, BS | 1 |
| Lee, K | 1 |
| Pham, NM | 1 |
| Nanri, A | 1 |
| Kurotani, K | 1 |
| Kuwahara, K | 1 |
| Kume, A | 1 |
| Sato, M | 1 |
| Hayabuchi, H | 1 |
| Mizoue, T | 1 |
| Paciência, I | 1 |
| Barros, H | 1 |
| Araújo, J | 1 |
| Ramos, E | 1 |
| Ritchie, K | 1 |
| Ancelin, ML | 1 |
| Amieva, H | 1 |
| Rouaud, O | 1 |
| Carrière, I | 1 |
| Azagba, S | 1 |
| Langille, D | 1 |
| Asbridge, M | 1 |
| Owens, J | 1 |
| Yamada, K | 1 |
| Kobayashi, M | 1 |
| Kanda, T | 1 |
| Muñoz, CX | 1 |
| Johnson, EC | 1 |
| McKenzie, AL | 1 |
| Guelinckx, I | 1 |
| Graverholt, G | 1 |
| Casa, DJ | 1 |
| Maresh, CM | 1 |
| Armstrong, LE | 1 |
| Wang, L | 1 |
| Shen, X | 1 |
| Wu, Y | 1 |
| Zhang, D | 1 |
| Solfrizzi, V | 1 |
| Panza, F | 1 |
| Imbimbo, BP | 1 |
| D'Introno, A | 1 |
| Galluzzo, L | 1 |
| Gandin, C | 1 |
| Misciagna, G | 1 |
| Guerra, V | 1 |
| Osella, A | 1 |
| Baldereschi, M | 1 |
| Di Carlo, A | 1 |
| Inzitari, D | 1 |
| Seripa, D | 1 |
| Pilotto, A | 1 |
| Sabbá, C | 1 |
| Logroscino, G | 1 |
| Scafato, E | 1 |
| Smith, A | 1 |
| Grosso, G | 1 |
| Micek, A | 1 |
| Castellano, S | 1 |
| Pajak, A | 1 |
| Galvano, F | 1 |
| Pieróg, M | 1 |
| Townsend, SE | 1 |
| Dixon, RS | 1 |
| Hickman, ET | 1 |
| Lee, SM | 1 |
| Tse, WS | 1 |
| Chan, CC | 1 |
| Shiu, SY | 1 |
| Chung, PY | 1 |
| Cheng, SH | 1 |
| Brooks, KP | 1 |
| Robles, TF | 1 |
| Luebbe, AM | 1 |
| Bell, DJ | 1 |
| Regestein, Q | 1 |
| Natarajan, V | 1 |
| Pavlova, M | 1 |
| Kawasaki, S | 1 |
| Gleason, R | 1 |
| Koff, E | 1 |
| Dawkins, L | 1 |
| Shahzad, FZ | 1 |
| Ahmed, SS | 1 |
| Edmonds, CJ | 1 |
| Benko, CR | 1 |
| Farias, AC | 1 |
| Farias, LG | 1 |
| Pereira, EF | 1 |
| Louzada, FM | 1 |
| Cordeiro, ML | 1 |
| Lucas, M | 1 |
| Mirzaei, F | 1 |
| Pan, A | 1 |
| Okereke, OI | 1 |
| Willett, WC | 1 |
| O'Reilly, ÉJ | 1 |
| Koenen, K | 1 |
| Ascherio, A | 1 |
| Berkowitz, SA | 1 |
| Khaliq, S | 1 |
| Haider, S | 1 |
| Naqvi, F | 1 |
| Perveen, T | 1 |
| Saleem, S | 1 |
| Haleem, DJ | 2 |
| Yoshimura, R | 1 |
| Nakamura, J | 1 |
| Lapane, KL | 1 |
| Cooke, ME | 1 |
| Altmaier, E | 1 |
| Emeny, RT | 1 |
| Krumsiek, J | 1 |
| Lacruz, ME | 1 |
| Lukaschek, K | 1 |
| Häfner, S | 1 |
| Kastenmüller, G | 1 |
| Römisch-Margl, W | 1 |
| Prehn, C | 1 |
| Mohney, RP | 1 |
| Evans, AM | 1 |
| Milburn, MV | 1 |
| Illig, T | 1 |
| Adamski, J | 1 |
| Theis, F | 1 |
| Suhre, K | 1 |
| Ladwig, KH | 1 |
| Leutgeb, U | 1 |
| Martus, P | 1 |
| Büyükokuroğlu, ME | 1 |
| Demirezer, LO | 1 |
| Güvenalp, Z | 1 |
| Sudakov, SK | 1 |
| Medvedeva, OF | 1 |
| Rusakova, IV | 1 |
| Figurina, IB | 1 |
| El Yacoubi, M | 1 |
| Costentin, J | 1 |
| Vaugeois, JM | 1 |
| Pomerleau, CS | 1 |
| Pomerleau, OF | 1 |
| Snedecor, SM | 1 |
| Gaulrapp, S | 1 |
| Kardia, SL | 1 |
| Broderick, P | 1 |
| Benjamin, AB | 1 |
| Hintikka, J | 1 |
| Tolmunen, T | 1 |
| Honkalampi, K | 1 |
| Haatainen, K | 1 |
| Koivumaa-Honkanen, H | 1 |
| Tanskanen, A | 1 |
| Viinamäki, H | 1 |
| Volcy, M | 1 |
| Tepper, SJ | 1 |
| Rapoport, AM | 1 |
| Sheftell, FD | 1 |
| Bigal, ME | 1 |
| Ouellet, N | 1 |
| Morris, DL | 1 |
| McCrae, CS | 1 |
| Rowe, MA | 1 |
| Dautovich, ND | 1 |
| Lichstein, KL | 1 |
| Durrence, HH | 1 |
| Riedel, BW | 1 |
| Taylor, DJ | 1 |
| Bush, AJ | 1 |
| Rickels, K | 1 |
| Weise, C | 1 |
| Case, G | 1 |
| Hucker, H | 1 |
| Veleber, DM | 1 |
| Templer, DI | 1 |
| Gilliland, K | 1 |
| Andress, D | 1 |
| Regestein, QR | 1 |
| Reich, P | 1 |
| Greden, JF | 2 |
| Victor, BS | 1 |
| Fontaine, P | 2 |
| Lubetsky, M | 2 |
| Yasmeen, A | 1 |
| Haleem, MA | 1 |
| Zafar, A | 1 |
| Turner, J | 1 |
| Leibenluft, E | 1 |
| Fiero, PL | 1 |
| Bartko, JJ | 1 |
| Moul, DE | 1 |
| Rosenthal, NE | 1 |
| Cacciatore, R | 1 |
| Helbling, A | 1 |
| Jost, C | 1 |
| Hess, B | 1 |
| Flores, GB | 1 |
| Andrade, F | 1 |
| Lima, DR | 1 |
| Bernstein, GA | 1 |
| Carroll, ME | 1 |
| Thuras, PD | 1 |
| Cosgrove, KP | 1 |
| Roth, ME | 1 |
| Suomela, T | 1 |
| Henriksson, M | 1 |
| Cole, JO | 1 |
| Pope, HG | 1 |
| LaBrie, R | 1 |
| Ionescu-Pioggia, M | 1 |
| Chamberlin, K | 1 |
| Lutz, EG | 1 |
| Silverman, K | 1 |
| Evans, SM | 1 |
| Strain, EC | 1 |
| Griffiths, RR | 1 |
| Cantú, TG | 1 |
| Korek, JS | 1 |
| Mino, Y | 1 |
| Yasuda, N | 1 |
| Fujimura, T | 1 |
| Ohara, H | 1 |
| Clementz, GL | 1 |
| Dailey, JW | 1 |
| Golda, V | 1 |
| Petr, R | 1 |
| Cleaver, JE | 1 |
| Jahnke, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Consumption of Energy Drinks on Hemodynamics, Blood Glucose, Short Term Memory, Vigilance and Perception in Healthy Adults[NCT04961086] | 76 participants (Actual) | Interventional | 2021-06-29 | Completed | |||
| The Impact of Energy Drinks on the Manual Dexterity of Final Year Dental Students[NCT02535143] | Phase 4 | 60 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Pilot Study on Subjective Efficiency of Caffeine in ADCY5-related Dyskinesia[NCT04351360] | 20 participants (Anticipated) | Observational | 2020-04-10 | Not yet recruiting | |||
| Effects of Single-dose L-theanine on Motor Cortex Excitability in Healthy Subjects: A Double-blinded, Randomized Order, Cross-over Paired-Pulse Transcranial Magnetic Stimulation Study[NCT04749745] | Early Phase 1 | 11 participants (Actual) | Interventional | 2020-06-09 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The changes of Short-interval Intracortical Inhibition (SICI), Intracortical Facilitation (ICF), and Long-interval Intracortical Inhibition (LICI) before and 30 minutes after each drug administration.~SICI, ICF and LICI are paired-pulse TMS (ppTMS)-EMG outcome measures that assess the activity of motor cortex GABA-A, NMDA and GABA-B interneurons, respectively. They are measured by the ratio between the peak-to-peak amplitude of motor-evoked potential (MEP) elicited by a testing TMS pulse (120% of the intensity of the resting motor threshold, following a conditioning pulse at different inter-stimuli interval, 2-5 milliseconds for SICI, 10-20 milliseconds for ICF, 100-200 milliseconds for LICI) and the peak-to-peak MEP amplitude elicited by a single pulse (120% of the intensity of the resting motor threshold).~The baseline-to-post-drug change of SICI, ICF and LICI elicited by L-theanine will be compared to that elicited by placebo within each subject." (NCT04749745)
Timeframe: Before and 30 minutes after each drug administration (no long-term follow up as this is a study on acute effect of a single-dose agent).
| Intervention | Ratio (Mean) | ||
|---|---|---|---|
| SICI | ICF | LICI | |
| L-Theanine | 0.059 | 0.073 | 0.145 |
| Placebo | 0.005 | -0.341 | -0.068 |
7 reviews available for caffeine and Depression
| Article | Year |
|---|---|
Insufficient sleep in adolescents and young adults: an update on causes and consequences.
Topics: Accidents, Traffic; Adolescent; Caffeine; Communications Media; Depression; Humans; Obesity; Sleep; | 2014 |
Involvement of adenosine A2A receptors in depression and anxiety.
Topics: Adenosine A2 Receptor Antagonists; Animals; Anxiety; Caffeine; Depression; Humans; Receptor, Adenosi | 2014 |
Coffee and caffeine consumption and depression: A meta-analysis of observational studies.
Topics: Caffeine; Coffee; Depression; Dose-Response Relationship, Drug; Humans; Observational Studies as Top | 2016 |
Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies.
Topics: Caffeine; Coffee; Databases, Factual; Depression; Dose-Response Relationship, Drug; Humans; Observat | 2016 |
Caffeine and psychiatric symptoms: a review.
Topics: Anxiety; Caffeine; Central Nervous System Stimulants; Depression; Humans; Mental Disorders; Primary | 2004 |
Caffeine in electroconvulsive therapy.
Topics: Benzoates; Caffeine; Depression; Drug Combinations; Electroconvulsive Therapy; Humans; Mood Disorder | 1991 |
Psychotropic effects of caffeine.
Topics: Affect; Anxiety; Behavior; Caffeine; Depression; Dose-Response Relationship, Drug; Female; Food Anal | 1988 |
6 trials available for caffeine and Depression
| Article | Year |
|---|---|
A pilot cluster-randomised study to increase sleep duration by decreasing electronic media use at night and caffeine consumption in adolescents.
Topics: Adolescent; Adolescent Behavior; Caffeine; Cell Phone; Depression; Female; Humans; Male; Mental Heal | 2019 |
Caffeinated coffee enhances co-operative behavior in the Mixed Motive Game in healthy volunteers.
Topics: Adolescent; Adult; Affect; Blood Pressure; Caffeine; Coffee; Cooperative Behavior; Cross-Over Studie | 2009 |
Expectation of having consumed caffeine can improve performance and mood.
Topics: Adolescent; Adult; Affect; Caffeine; Depression; Double-Blind Method; Feeding Behavior; Female; Huma | 2011 |
Tricyclic plasma levels in depressed outpatients treated with amitriptyline.
Topics: Amitriptyline; Caffeine; Depression; Female; Humans; Male; Nortriptyline; Smoking | 1983 |
Assessing the subjective effects of stimulants in casual users. A methodology and preliminary results.
Topics: Adult; Anxiety; Caffeine; Central Nervous System Stimulants; Depression; Dextroamphetamine; Emotions | 1978 |
Withdrawal syndrome after the double-blind cessation of caffeine consumption.
Topics: Adult; Caffeine; Depression; Diet; Double-Blind Method; Female; Headache; Humans; Interview, Psychol | 1992 |
72 other studies available for caffeine and Depression
| Article | Year |
|---|---|
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholin | 2018 |
Effects of black tea consumption and caffeine intake on depression risk in black tea consumers.
Topics: Adult; Caffeine; Depression; Female; Humans; Male; Risk Assessment; Tea; Young Adult | 2021 |
Association Between Homeschooling and Adolescent Sleep Duration and Health During COVID-19 Pandemic High School Closures.
Topics: Adolescent; Adolescent Health; Caffeine; Communicable Disease Control; COVID-19; Cross-Sectional Stu | 2022 |
Structural and functional characteristics of the hippocampus in depressive-like recipients after transplantation of in vitro caffeine-modulated immune cells.
Topics: Animals; Brain-Derived Neurotrophic Factor; Caffeine; Cytokines; Depression; Disease Models, Animal; | 2022 |
Caffeine intake is associated with less severe depressive symptoms in noncancer populations: an analysis based on NHANES 2007-2016.
Topics: Caffeine; Depression; Humans; Linear Models; Neoplasms; Nutrition Surveys | 2023 |
Does the timing of intake matter? Association between caffeine intake and depression: Evidence from the National Health and Nutrition Examination Survey.
Topics: Adult; Caffeine; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Humans; Nutrition | 2023 |
Relationship between Baseline Physical Activity and Generalized Anxiety Disorder and Major Depressive Disorder Treatment Outcomes.
Topics: Adult; Anxiety; Anxiety Disorders; Caffeine; Depression; Depressive Disorder, Major; Humans; Retrosp | 2023 |
Lacidipine attenuates caffeine-induced anxiety-like symptoms in mice: Role of calcium-induced oxido-nitrosative stress.
Topics: Animals; Anxiety; Behavior, Animal; Biomarkers; Brain; Caffeine; Calcium; Depression; Dihydropyridin | 2019 |
Caffeine prevents neurodegeneration and behavioral alterations in a mice model of agitated depression.
Topics: Animals; Behavior, Animal; Brain; Caffeine; Central Nervous System Stimulants; Depression; Gliosis; | 2020 |
Thumb twitch during repetitive transcranial magnetic stimulation in a case with medication-resistant depression: A potential role of caffeine.
Topics: Caffeine; Depression; Depressive Disorder, Major; Humans; Thumb; Transcranial Magnetic Stimulation | 2020 |
New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation.
Topics: Animals; Antidepressive Agents; Caffeine; Corticosterone; Depression; Disease Models, Animal; Hippoc | 2020 |
Pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat.
Topics: Age Factors; alpha-Methyltyrosine; Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Behav | 2020 |
Caffeine protects against stress-induced murine depression through activation of PPARγC1α-mediated restoration of the kynurenine pathway in the skeletal muscle.
Topics: Animals; Caffeine; Cell Line; Depression; Kynurenine; Male; Mice; Mice, Inbred C57BL; Muscle, Skelet | 2021 |
The viability of an ecologically valid chronic sleep restriction and circadian timing protocol: An examination of sample attrition, compliance, and effectiveness at impacting sleepiness and mood.
Topics: Actigraphy; Adolescent; Adult; Affect; Anxiety; Behavior; Caffeine; Circadian Rhythm; Depression; Fe | 2017 |
Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt, Slc6a15 and Adora1 gene expression.
Topics: Amino Acid Transport Systems, Neutral; Animals; Antidepressive Agents, Second-Generation; Behavior, | 2017 |
Energy drinks, caffeine, junk food, breakfast, depression and academic attainment of secondary school students.
Topics: Academic Success; Breakfast; Caffeine; Child; Cross-Sectional Studies; Depression; Depressive Disord | 2018 |
Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project.
Topics: Adult; Age Factors; Caffeine; Central Nervous System Stimulants; Coffee; Depression; Diet, Mediterra | 2018 |
Mood rhythmicity is associated with depressive symptoms and caffeinated drinks consumption in South American young adults.
Topics: Adult; Affect; Beverages; Caffeine; Circadian Rhythm; Depression; Female; Humans; Male; Young Adult | 2019 |
The science of tea's mood-altering magic.
Topics: Adenosine; Affect; Alpha Rhythm; Animals; Antioxidants; Behavior; Beta Rhythm; Blood-Brain Barrier; | 2019 |
Inverse association between caffeine intake and depressive symptoms in US adults: data from National Health and Nutrition Examination Survey (NHANES) 2005-2006.
Topics: Adolescent; Adult; Aged; Caffeine; Cross-Sectional Studies; Depression; Female; Humans; Male; Middle | 2019 |
Sex and housing conditions modify the effects of adolescent caffeine exposure on anxiety-like and depressive-like behavior in the rat.
Topics: Age Factors; Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Caffeine; Depression; Depressive | 2019 |
Chronic caffeine exposure in adolescence promotes diurnal, biphasic mood-cycling and enhanced motivation for reward in adult mice.
Topics: Affect; Age Factors; Animals; Anxiety; Behavior, Animal; Caffeine; Depression; Locomotion; Male; Mic | 2019 |
Intake of Coffee Associated With Decreased Depressive Symptoms Among Elderly Japanese Women: A Multi-Center Cross-Sectional Study.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Caffeine; Coffee; Cross-Sectional Studies; De | 2020 |
Relationship between daily coffee intake and suicidal ideation.
Topics: Adult; Caffeine; Coffee; Cohort Studies; Depression; Female; Humans; Logistic Models; Male; Middle A | 2019 |
Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population.
Topics: Adult; Aged; Caffeine; Coffee; Confounding Factors, Epidemiologic; Cross-Sectional Studies; Depressi | 2014 |
Association between sleep duration and blood pressure in adolescents.
Topics: Adolescent; Blood Pressure; Caffeine; Cross-Sectional Studies; Depression; Female; Humans; Male; Sel | 2013 |
The association between caffeine and cognitive decline: examining alternative causal hypotheses.
Topics: Aged; Aged, 80 and over; Body Mass Index; Caffeine; Coffee; Cognition; Cognition Disorders; Cross-Se | 2014 |
An emerging adolescent health risk: caffeinated energy drink consumption patterns among high school students.
Topics: Achievement; Adolescent; Adolescent Behavior; Caffeine; Canada; Child; Cross-Sectional Studies; Depr | 2014 |
Habitual total water intake and dimensions of mood in healthy young women.
Topics: Adolescent; Affect; Anger; Body Mass Index; Caffeine; Depression; Diet; Drinking; Exercise; Female; | 2015 |
Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging.
Topics: Aged; Aged, 80 and over; Aging; Caffeine; Coffee; Cognitive Dysfunction; Depression; Feeding Behavio | 2015 |
Caffeine consumption and self-assessed stress, anxiety, and depression in secondary school children.
Topics: Adolescent; Anxiety; Anxiety Disorders; Caffeine; Carbonated Beverages; Child; Coffee; Cross-Section | 2015 |
Synergistic antidepressant-like effect of the joint administration of caffeine and NMDA receptor ligands in the forced swim test in mice.
Topics: Animals; Antidepressive Agents; Caffeine; Depression; Disease Models, Animal; Mice; Motor Activity; | 2016 |
Caffeine enhances the antidepressant-like activity of common antidepressant drugs in the forced swim test in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Caffeine; Chromatography, High Pressure Liq | 2016 |
Chronic caffeine produces sexually dimorphic effects on amphetamine-induced behavior, anxiety and depressive-like behavior in adolescent rats.
Topics: Amphetamines; Animals; Anxiety; Behavior, Animal; Caffeine; Depression; Female; Male; Rats; Rats, Sp | 2016 |
Caffeine, cognitive failures and health in a non-working community sample.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Attention; Caffeine; Central Nervous System Stimulants; | 2009 |
Recent depressive and anxious symptoms predict cortisol responses to stress in men.
Topics: Alcohol Drinking; Anxiety; Caffeine; Depression; Female; Health Behavior; Humans; Hydrocortisone; Ma | 2009 |
Mountain Dew or mountain don't?: a pilot investigation of caffeine use parameters and relations to depression and anxiety symptoms in 5th- and 10th-grade students.
Topics: Adolescent; Anxiety; Caffeine; Child; Cross-Sectional Studies; Depression; Female; Humans; Male; Pil | 2009 |
Sleep debt and depression in female college students.
Topics: Adolescent; Antidepressive Agents; Caffeine; Depression; Female; Humans; Personality Inventory; Psyc | 2010 |
Potential link between caffeine consumption and pediatric depression: A case-control study.
Topics: Adolescent; Analysis of Variance; Beverages; Caffeine; Case-Control Studies; Central Nervous System | 2011 |
Coffee, caffeine, and risk of depression among women.
Topics: Adult; Aged; Caffeine; Central Nervous System Stimulants; Coffee; Depression; Depressive Disorder; F | 2011 |
Coffee consumption and depression risk: comment on "coffee, caffeine, and risk of depression among women".
Topics: Caffeine; Central Nervous System Stimulants; Coffee; Depression; Depressive Disorder; Female; Humans | 2011 |
Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats.
Topics: Animals; Brain; Caffeine; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Immo | 2012 |
[Effects of smoking and caffeine on pharmacological treatment for patients with schizophrenia and depression].
Topics: Caffeine; Depression; Drug Interactions; Fluvoxamine; Humans; Risperidone; Schizophrenia; Smoking | 2011 |
Why coffee perks people up. A large study suggests the caffeinated version may boost mood.
Topics: Affect; Caffeine; Cardiovascular Diseases; Central Nervous System Stimulants; Coffee; Depression; Fe | 2012 |
Coffee or camaraderie?
Topics: Caffeine; Central Nervous System Stimulants; Coffee; Depression; Depressive Disorder; Female; Humans | 2012 |
Metabolomic profiles in individuals with negative affectivity and social inhibition: a population-based study of Type D personality.
Topics: Adult; Aged; Androsterone; Anxiety Disorders; Caffeine; Case-Control Studies; Cross-Sectional Studie | 2013 |
Regular intake of non-opioid analgesics is associated with an increased risk of restless legs syndrome in patients maintained on antidepressants.
Topics: Adrenergic beta-Antagonists; Adult; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Anti | 2002 |
Sedative, anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Caffeine; Central Nervous System Stimulants; | 2002 |
Effect of social isolation on behavioral parameters and sensitivity of rats to morphine and caffeine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Depressi | 2003 |
Adenosine A2A receptors and depression.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Caff | 2003 |
Heterogeneity in phenotypes based on smoking status in the Great Lakes Smoker Sibling Registry.
Topics: Adult; Alcohol Drinking; Alcohol-Related Disorders; Attention Deficit Disorder with Hyperactivity; C | 2004 |
Daily tea drinking is associated with a low level of depressive symptoms in the Finnish general population.
Topics: Adult; Caffeine; Depression; Female; Finland; Humans; Male; Middle Aged; Multivariate Analysis; Surv | 2005 |
Botulinum toxin A for the treatment of greater occipital neuralgia and trigeminal neuralgia: a case report with pathophysiological considerations.
Topics: Acetaminophen; Adult; Analgesics; Anxiety; Aspirin; Botulinum Toxins, Type A; Caffeine; Colitis, Ulc | 2006 |
Sleep satisfaction of older adults living in the community: identifying associated behavioral and health factors.
Topics: Aged; Anxiety; Attitude to Health; Caffeine; Cross-Sectional Studies; Depression; Drug-Related Side | 2006 |
Sleep hygiene practices in two community dwelling samples of older adults.
Topics: Aged; Aged, 80 and over; Alcohol Drinking; Anxiety; Caffeine; Central Nervous System Stimulants; Dem | 2006 |
Effects of caffeine on anxiety and depression.
Topics: Adult; Anxiety; Caffeine; Depression; Double-Blind Method; Female; Hostility; Humans; Male | 1984 |
Ad lib caffeine consumption, symptoms of caffeinism, and academic performance.
Topics: Age Factors; Anxiety; Caffeine; Depression; Female; Humans; Male; Psychophysiologic Disorders; Sex F | 1981 |
A sleep clinic within a general hospital psychiatry service.
Topics: Adult; Antidepressive Agents; Arousal; Caffeine; Depression; Female; Hospitals, General; Humans; Mal | 1980 |
Caffeine-withdrawal headache: a clinical profile.
Topics: Adult; Anxiety; Caffeine; Depression; Female; Headache; Humans; Substance Withdrawal Syndrome | 1980 |
24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression.
Topics: Analysis of Variance; Animals; Brain; Caffeine; Depression; Dose-Response Relationship, Drug; Drug A | 1995 |
Incidental information processing: effects of mood, sex and caffeine.
Topics: Adult; Affect; Anxiety; Caffeine; Depression; Dominance, Cerebral; Female; Humans; Male; Memory; Men | 1993 |
Depressive symptoms and the self-reported use of alcohol, caffeine, and carbohydrates in normal volunteers and four groups of psychiatric outpatients.
Topics: Alcohol Drinking; Alcoholism; Ambulatory Care; Analysis of Variance; Caffeine; Coffee; Depression; D | 1993 |
[Episodic headache, diminished performance and depressive mood].
Topics: Adult; Caffeine; Depression; Fatigue; Headache; Humans; Male; Substance Withdrawal Syndrome | 1996 |
Can coffee help fighting the drug problem? Preliminary results of a Brazilian youth drug study.
Topics: Adolescent; Adult; Brazil; Caffeine; Child; Chlorogenic Acid; Coffee; Cohort Studies; Depression; Fe | 2000 |
Caffeine dependence in teenagers.
Topics: Adolescent; Alcohol Drinking; Analysis of Variance; Anxiety; Caffeine; Central Nervous System Stimul | 2002 |
[Persistent insomnia in a depressed athlete].
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Caffeine; Central Nervous System | 2001 |
Anxiety and depression associated with caffeinism among psychiatric inpatients.
Topics: Anxiety; Caffeine; Depression; Hospitalization; Humans; Mental Disorders; Psychological Tests | 1978 |
Restless legs, anxiety and caffeinism.
Topics: Adolescent; Adult; Anxiety; Arousal; Caffeine; Coffee; Depression; Female; Humans; Male; Muscle Cont | 1978 |
Caffeine consumption and anxiety and depressive symptomatology among medical students.
Topics: Adult; Alcohol Drinking; Anxiety; Caffeine; Chi-Square Distribution; Depression; Female; Humans; Jap | 1990 |
Animal model of depression: drug induced changes independent of changes in exploratory activity.
Topics: Animals; Antidepressive Agents; Caffeine; Depression; Disease Models, Animal; Ergolines; Exploratory | 1987 |
Repair replication of mammalian cell DNA: effects of compounds that inhibit DNA synthesis or dark repair.
Topics: Acridines; Animals; Autoradiography; Bromodeoxyuridine; Caffeine; Centrifugation, Density Gradient; | 1969 |
[Contribution to the treatment of depressions].
Topics: Aged; Antidepressive Agents; Caffeine; Depression; Depressive Disorder, Major; Female; Humans; Injec | 1967 |