Page last updated: 2024-10-24

caffeine and Delayed Effects, Prenatal Exposure

caffeine has been researched along with Delayed Effects, Prenatal Exposure in 165 studies

Research Excerpts

ExcerptRelevanceReference
"Epidemiological studies have revealed that caffeine consumption during pregnancy is associated with adverse gestational outcomes, yet the underlying mechanisms remain obscure."9.05Impacts of Caffeine during Pregnancy. ( Chen, Q; Duan, E; Qian, J; Ward, SM; Zhang, Y, 2020)
"This aim of this study was to conduct a systematic literature review on the association between maternal caffeine intake during pregnancy and attention deficit hyperactivity disorder (ADHD) in childhood."8.91[Caffeine consumption during pregnancy and attention deficit hyperactivity disorder (ADHD): a systematic literature review]. ( Anselmi, L; Santos, IS; Schmidt, V; Silva, Bdel P, 2015)
"Considerable controversy exists regarding the relation between maternal caffeine intake during pregnancy and risk of low birth weight (birth weight <2,500 g)."8.90Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis. ( Chen, LW; Chong, MF; Neelakantan, N; Pan, A; van Dam, RM; Wu, Y, 2014)
" Among the external factors, chemical compounds stand out, which include caffeine, since its consumption is common among women, including during pregnancy."8.12Behavioral, genetic and biochemical changes in the brain of the offspring of female mice treated with caffeine during pregnancy and lactation. ( Boeck, CR; Borges Correa, MEA; Budni, J; Damiani, AP; de Andrade, VM; de Bem Silveira, G; de Marcos, PS; Effting, PS; Franca, IB; Magenis, ML; Medeiros, EB; Muller, AP; Silveira, PCL, 2022)
"Low to moderate caffeine consumption during pregnancy was not associated with any persistent adverse effects concerning the child's neurodevelopment up to 8 years of age."8.02Maternal caffeine intake during pregnancy and child neurodevelopment up to eight years of age-Results from the Norwegian Mother, Father and Child Cohort Study. ( Berglundh, S; Brandlistuen, R; Brantsæter, AL; Jacobsson, B; Sengpiel, V; Solé-Navais, P; Vollrath, M, 2021)
"Our previous studies confirmed that prenatal caffeine exposure (PCE) could induce susceptibility to osteoarthritis in adult offspring rats due to poor chondrocyte differentiation, but its mechanism remains to be further investigated."7.96Subchondral bone dysplasia mediates susceptibility to osteoarthritis in female adult offspring rats induced by prenatal caffeine exposure. ( Chen, L; Magdalou, J; Tan, Y; Wang, H; Wen, Y; Xiao, H; Xie, X, 2020)
"Maternal caffeine intake during pregnancy is associated with an increased risk of childhood obesity."7.96Associations of maternal caffeine intake during pregnancy with abdominal and liver fat deposition in childhood. ( Gaillard, R; Hulst, ME; Jaddoe, VW; Oei, EH; Voerman, E, 2020)
"This study aimed to evaluate female adult offspring induced by prenatal caffeine exposure (PCE) are susceptible to non-alcoholic fatty liver disease (NAFLD) and to explore the underlying programming mechanisms."7.91Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway. ( Hu, S; Luo, H; Wang, H; Xia, L; Xu, D; Xu, Y; Yu, H, 2019)
"Few previous studies have investigated the association between prenatal caffeine intake and birth size (small for gestational age [SGA], preterm birth, and birthweight Z-score) in Japan."7.91Dose-dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study. ( Ait Bamai, Y; Araki, A; Itoh, S; Kishi, R; Kobayashi, S; Minatoya, M; Miyashita, C; Murata, K; Saijo, Y; Sata, F; Yamazaki, K, 2019)
"Maternal antenatal, but not paternal or grandparental, caffeine intake is associated with higher offspring adiposity and obesity risk at age 5 and 9 y, with stronger associations observed for coffee caffeine."7.91Maternal, but not paternal or grandparental, caffeine intake is associated with childhood obesity and adiposity: The Lifeways Cross-Generation Cohort Study. ( Chen, LW; Kelleher, CC; Mehegan, J; Murrin, CM; Phillips, CM, 2019)
"To study the association between maternal caffeine intake during pregnancy and the child's weight gain and overweight risk up to 8 years."7.88Maternal caffeine intake during pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study. ( Alexander, J; Bacelis, J; Botton, J; Brantsæter, AL; Elfvin, A; Haugen, M; Jacobsson, B; Meltzer, HM; Papadopoulou, E; Sengpiel, V, 2018)
"Our previous in vivo studies showed that prenatal caffeine exposure (PCE) could restrain the development of chondrogenesis, which may delay fetal articular cartilage development and increase susceptibility to osteoarthritis in adults."7.88Prenatal caffeine exprosure increases adult female offspring rat's susceptibility to osteoarthritis via low-functional programming of cartilage IGF-1 with histone acetylation. ( Chen, L; Li, J; Lu, K; Magdalou, J; Ni, Q; Tan, Y; Wang, H; Zhao, Z, 2018)
"Epidemiologic investigations suggest that excessive intake of caffeine during pregnancy is one of the risk factors for osteoporosis in adult offspring."7.88Intrauterine Programming of Glucocorticoid-Insulin-Like Growth Factor-1 Axis-Mediated Developmental Origin of Osteoporosis Susceptibility in Female Offspring Rats with Prenatal Caffeine Exposure. ( Chen, L; Jiang, H; Magdalou, J; Qin, J; Shangguan, Y; Tan, Y; Wang, H; Wen, Y, 2018)
"We examined the association of hypospadias risk with maternal smoking and consumption of alcohol and caffeine."7.85Maternal Smoking, Alcohol, and Caffeine Exposures and Risk of Hypospadias. ( Carmichael, SL; Ma, C; Shaw, GM, 2017)
"To examine the association between maternal caffeine consumption from coffee and tea during pregnancy and offspring behavioral disorders."7.85Maternal Caffeine Consumption during Pregnancy and Behavioral Disorders in 11-Year-Old Offspring: A Danish National Birth Cohort Study. ( Bech, BH; Hvolgaard Mikkelsen, S; Niclasen, J; Obel, C; Olsen, J, 2017)
"This study aimed to investigate the association between prenatal caffeine ingestion (PCI) and risk of postnatal pulmonary inflammation."7.85Prenatal caffeine ingestion increases susceptibility to pulmonary inflammation in adult female rat offspring. ( Chen, T; Hou, LF; Liu, HX; Liu, S; Ping, J; Qu, W; Wen, X; Yan, HY, 2017)
"Objective To investigate the association between maternal caffeine intake during pregnancy and infant anthropometric measurements at age 3 and 6 months."7.85Caffeine Intake During Pregnancy in Different Intrauterine Environments and its Association with Infant Anthropometric Measurements at 3 and 6 Months of Age. ( Bernardi, JR; Bosa, VL; da Silva, CH; de Brito, ML; de Medeiros, TS; Goldani, MZ, 2017)
"The associations of maternal caffeine intake during pregnancy with offspring growth patterns and body fat and insulin levels at school age were examined."7.83Maternal caffeine intake during pregnancy, early growth, and body fat distribution at school age. ( Franco, OH; Gaillard, R; Gishti, O; Hofman, A; Jaddoe, VW; Voerman, E, 2016)
"Postnatal administration of caffeine may reduce the risk of cerebral palsy (CP) in vulnerable low-birth-weight neonates."7.83Intake of Caffeinated Soft Drinks before and during Pregnancy, but Not Total Caffeine Intake, Is Associated with Increased Cerebral Palsy Risk in the Norwegian Mother and Child Cohort Study. ( Brantsæter, AL; Eichelberger, KY; Lie, RT; Meltzer, HM; Moster, D; Stoltenberg, C; Strandberg-Larsen, K; Tollånes, MC; Wilcox, AJ, 2016)
"Studies evaluating caffeine intake during pregnancy and long-term outcomes, such as the child's neurobehaviour, are still scarce and their results are inconsistent."7.83Caffeine consumption during pregnancy and ADHD at the age of 11 years: a birth cohort study. ( Anselmi, L; Del-Ponte, B; Matijasevich, A; Munhoz, TN; Santos, IS; Tovo-Rodrigues, L, 2016)
"Prenatal caffeine exposure (PCE) alters the hypothalamic-pituitary-adrenocortical (HPA) axis-associated neuroendocrine metabolic programming and induces an increased susceptibility to metabolic syndrome (MS) in intrauterine growth retardation (IUGR) offspring rats."7.81Gender-specific increase in susceptibility to metabolic syndrome of offspring rats after prenatal caffeine exposure with post-weaning high-fat diet. ( Chen, L; Guo, Y; He, Z; Li, J; Luo, H; Ma, L; Magdalou, J; Wang, H; Wu, Y; Zhang, L, 2015)
"Although caffeine is commonly consumed during pregnancy, there are few reports on the association of in utero caffeine exposure with offspring cognition or behavior during childhood."7.81Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age. ( Keim, SA; Klebanoff, MA, 2015)
"We hypothesized that caffeine improves respiratory function via an anti-inflammatory effect in lungs of a lipopolysaccharide (LPS)-induced pro-inflammatory amnionitis rat pup model."7.80Anti-inflammatory effect of caffeine is associated with improved lung function after lipopolysaccharide-induced amnionitis. ( Balan, KV; Jafri, A; Kc, P; Köroğlu, OA; MacFarlane, PM; Martin, RJ; Zenebe, WJ, 2014)
"Human studies that have investigated the association between caffeine intake during pregnancy and offspring's behavioral outcomes are scant and inconclusive."7.78Caffeine intake during pregnancy and risk of problem behavior in 5- to 6-year-old children. ( Hofland, L; Koot, HM; Loomans, EM; Van den Bergh, BR; van der Stelt, O; van der Wal, MF; Vrijkotte, TG, 2012)
"The aim of this work was to study whether caffeine or theophylline chronically consumed during pregnancy affect inhibitory adenylyl cyclase pathway mediated by adenosine, in rat brain of both mothers and full-term fetuses."7.73Chronic caffeine or theophylline intake during pregnancy inhibits A1 receptor function in the rat brain. ( Albasanz, JL; León, D; Martín, M; Ruíz, MA, 2005)
"To test the hypothesis that, in women with type 1 diabetes, prenatal smoking and caffeine consumption during pregnancy are associated with an increased risk of adverse maternal and perinatal outcomes."7.72Consequences of smoking and caffeine consumption during pregnancy in women with type 1 diabetes. ( Buncher, CR; Kalkwarf, H; Khoury, JC; Khoury, PR; McElvy, S; Miodovnik, M; Sibai, B, 2004)
"Excessive maternal caffeine exposure during pregnancy had cataractogenic effects on developing crystalline lenses in newborn rat eyes, both macroscopically and histopathologically."7.72Excessive maternal caffeine exposure during pregnancy is cataractogenic for neonatal crystalline lenses in rats: a biomicroscopic and histopathologic study. ( Alasehirli, B; Cengiz, B; Evereklioglu, C; Güldür, E; Pirbudak, L; Sari, I, 2004)
"To examine the association between maternal caffeine consumption during pregnancy and the risk of sudden infant death syndrome (SIDS)."7.70Heavy caffeine intake in pregnancy and sudden infant death syndrome. New Zealand Cot Death Study Group. ( Ford, RP; Mitchell, EA; Schluter, PJ; Scragg, R; Stewart, AW; Taylor, BJ, 1998)
"In this manuscript it is demonstrated that caffeine when administered to the rat (30 mg/kg per day) during pregnancy affected certain aspects of normal sexual differentiation of the fetal gonads."7.68Influence of caffeine administered during pregnancy on the early differentiation of fetal rat ovaries and testes. ( Magre, S; Pollard, I; Williamson, S, 1990)
"Caffeine, when administered in moderate (30 mg/kg X d) or high (60 mg/kg X d) doses during pregnancy, was shown to cause significant fetal growth retardation of both sexes."7.67Effects of caffeine administered during pregnancy on fetal development and subsequent function in the adult rat: prolonged effects on a second generation. ( Jabbour, H; Mehrabani, PA; Pollard, I, 1987)
"To evaluate the relationship of antecedent maternal smoking and caffeine consumption habits on the occurrence of apnea in their offspring, rates for central and obstructive apnea were analyzed in a cohort of mother-infant pairs."7.67Effects of maternal smoking and caffeine habits on infantile apnea: a retrospective study. ( Bendell, D; Duke, JC; Mattice, CD; McCaffree, MA; Orr, WC; Toubas, PL, 1986)
"Furthermore, caffeine treatment during pregnancy and lactation causes long-term behavioral changes in the mice offspring that manifest later in life."5.43Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine. ( Côrtes, Wda S; da Conceição, RR; da Rocha, FF; da Silva-Almeida, C; da Silveira, AL; de Azevedo Cruz Seara, F; Laureano-Melo, R; Marinho, BG; Reis, LC, 2016)
" This association demonstrated a dose-response relationship: OR=1."5.42Maternal caffeine intake during pregnancy and risk of obesity in offspring: a prospective cohort study. ( Ferber, JR; Li, DK; Odouli, R, 2015)
"Severe NAFLD appeared with higher Kleiner scores."5.40Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring. ( Chen, L; Huang, H; Liu, Y; Liu, Z; Ping, J; Shen, L; Wang, H; Wang, L; Wu, Y; Zhang, L, 2014)
"Caffeine is a widely used psychostimulant freely crossing the placental barrier."5.35Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar hypoxia in newborn rats and adenosine A2A and GABA A receptor mRNA transcription. ( Guénin, S; Larnicol, N; Perrin, Y; Picard, N, 2008)
" Prenatal caffeine at the dosage we have used in combination with malnutrition may produce lasting metabolic alterations in the nervous system related to the emergence of suckling behavior and general motor activity."5.29Combined effects of caffeine and malnutrition during pregnancy on suckling behavior in newborn rats. ( Joseph, F; Nakamoto, T; Narayanan, CH; Saito, T; Yoshino, S, 1994)
" Findings with alcohol and caffeine exposures and conduct disorder and oppositional-defiant disorder need more research, using more genetically sensitive designs."5.22Prenatal smoking, alcohol and caffeine exposure and offspring externalizing disorders: a systematic review and meta-analysis. ( Haan, E; Munafò, MR; Sallis, HM; Schellhas, L; Taylor, G; Westmoreland, KE; Zuccolo, L, 2022)
" In this study, a meta-analysis was first performed to suggest that paternal exposure to nicotine, ethanol, or caffeine is a high-risk factor for adverse pregnancy outcomes."5.22Paternal Nicotine/Ethanol/Caffeine Mixed Exposure Induces Offspring Rat Dysplasia and Its Potential "GC-IGF1" Programming Mechanism. ( Chen, L; Chen, M; Liu, Y; Qu, H; Wang, H; Xu, D; Zhang, C; Zhou, S; Zhu, J, 2022)
"Epidemiological studies have revealed that caffeine consumption during pregnancy is associated with adverse gestational outcomes, yet the underlying mechanisms remain obscure."5.05Impacts of Caffeine during Pregnancy. ( Chen, Q; Duan, E; Qian, J; Ward, SM; Zhang, Y, 2020)
"This aim of this study was to conduct a systematic literature review on the association between maternal caffeine intake during pregnancy and attention deficit hyperactivity disorder (ADHD) in childhood."4.91[Caffeine consumption during pregnancy and attention deficit hyperactivity disorder (ADHD): a systematic literature review]. ( Anselmi, L; Santos, IS; Schmidt, V; Silva, Bdel P, 2015)
"Considerable controversy exists regarding the relation between maternal caffeine intake during pregnancy and risk of low birth weight (birth weight <2,500 g)."4.90Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis. ( Chen, LW; Chong, MF; Neelakantan, N; Pan, A; van Dam, RM; Wu, Y, 2014)
"A risk analysis of in utero caffeine exposure is presented utilizing epidemiological studies and animal studies dealing with congenital malformation, pregnancy loss, and weight reduction."4.87Evaluation of the reproductive and developmental risks of caffeine. ( Brent, RL; Christian, MS; Diener, RM, 2011)
"The purpose of this review was to examine the literature assessing the relationship between prenatal exposure to nicotine, alcohol, caffeine, and psychosocial stress during pregnancy to the risk of developing behavioral problems related to attention deficit hyperactivity disorder (ADHD) in childhood."4.82Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. ( Dalsgaard, S; Henriksen, TB; Jarvelin, MR; Kotimaa, A; Linnet, KM; Moilanen, I; Obel, C; Olsen, J; Rodriguez, A; Thomsen, PH; Wisborg, K, 2003)
" Among the external factors, chemical compounds stand out, which include caffeine, since its consumption is common among women, including during pregnancy."4.12Behavioral, genetic and biochemical changes in the brain of the offspring of female mice treated with caffeine during pregnancy and lactation. ( Boeck, CR; Borges Correa, MEA; Budni, J; Damiani, AP; de Andrade, VM; de Bem Silveira, G; de Marcos, PS; Effting, PS; Franca, IB; Magenis, ML; Medeiros, EB; Muller, AP; Silveira, PCL, 2022)
"Despite the widespread use of caffeine including consumption during pregnancy, the effect of prenatal caffeine exposure on child brain development and behavior is unclear."4.12Prenatal caffeine exposure: association with neurodevelopmental outcomes in 9- to 11-year-old children. ( Manza, P; Volkow, ND; Zhang, R, 2022)
"Low to moderate caffeine consumption during pregnancy was not associated with any persistent adverse effects concerning the child's neurodevelopment up to 8 years of age."4.02Maternal caffeine intake during pregnancy and child neurodevelopment up to eight years of age-Results from the Norwegian Mother, Father and Child Cohort Study. ( Berglundh, S; Brandlistuen, R; Brantsæter, AL; Jacobsson, B; Sengpiel, V; Solé-Navais, P; Vollrath, M, 2021)
"Our previous studies confirmed that prenatal caffeine exposure (PCE) could induce susceptibility to osteoarthritis in adult offspring rats due to poor chondrocyte differentiation, but its mechanism remains to be further investigated."3.96Subchondral bone dysplasia mediates susceptibility to osteoarthritis in female adult offspring rats induced by prenatal caffeine exposure. ( Chen, L; Magdalou, J; Tan, Y; Wang, H; Wen, Y; Xiao, H; Xie, X, 2020)
"Maternal caffeine intake during pregnancy is associated with an increased risk of childhood obesity."3.96Associations of maternal caffeine intake during pregnancy with abdominal and liver fat deposition in childhood. ( Gaillard, R; Hulst, ME; Jaddoe, VW; Oei, EH; Voerman, E, 2020)
" Women noted their mother's reported use of diethylstilbestrol (DES), vitamins, tobacco, alcohol, and caffeine during pregnancy, and their mother's occupation during pregnancy."3.96Recalled maternal lifestyle behaviors associated with anti-müllerian hormone of adult female offspring. ( DeCherney, AH; Eubanks, AA; Hill, MJ; Kim, K; Mumford, SL; Nobles, CJ; Perkins, NJ; Schisterman, EF; Silver, RM; Sjaarda, LA; Ye, A; Zolton, JR, 2020)
"In the pregnancy period, it is recommended to limit the consumption of caffeine."3.96The dosage-dependent prenatal caffeine exposure adversely affects levels of integrin αVβ3 and MMP-9 in a rat model of embryo implantation. ( Tekmen, I; Yilmaz, F, 2020)
"This study aimed to evaluate female adult offspring induced by prenatal caffeine exposure (PCE) are susceptible to non-alcoholic fatty liver disease (NAFLD) and to explore the underlying programming mechanisms."3.91Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway. ( Hu, S; Luo, H; Wang, H; Xia, L; Xu, D; Xu, Y; Yu, H, 2019)
"Our previous studies demonstrated that prenatal caffeine exposure (PCE) caused thymopoiesis inhibition, immune disorders, and airway remodeling in offspring, which raises the question of whether PCE is a risk factor for postnatal asthma."3.91Inhibition of thymocyte autophagy-associated CD4 ( Hou, LF; Liu, HX; Ping, J; Qu, W; Wen, X; Yan, HY; Zhao, WH, 2019)
"Few previous studies have investigated the association between prenatal caffeine intake and birth size (small for gestational age [SGA], preterm birth, and birthweight Z-score) in Japan."3.91Dose-dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study. ( Ait Bamai, Y; Araki, A; Itoh, S; Kishi, R; Kobayashi, S; Minatoya, M; Miyashita, C; Murata, K; Saijo, Y; Sata, F; Yamazaki, K, 2019)
"Maternal antenatal, but not paternal or grandparental, caffeine intake is associated with higher offspring adiposity and obesity risk at age 5 and 9 y, with stronger associations observed for coffee caffeine."3.91Maternal, but not paternal or grandparental, caffeine intake is associated with childhood obesity and adiposity: The Lifeways Cross-Generation Cohort Study. ( Chen, LW; Kelleher, CC; Mehegan, J; Murrin, CM; Phillips, CM, 2019)
"To study the association between maternal caffeine intake during pregnancy and the child's weight gain and overweight risk up to 8 years."3.88Maternal caffeine intake during pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study. ( Alexander, J; Bacelis, J; Botton, J; Brantsæter, AL; Elfvin, A; Haugen, M; Jacobsson, B; Meltzer, HM; Papadopoulou, E; Sengpiel, V, 2018)
"Our previous in vivo studies showed that prenatal caffeine exposure (PCE) could restrain the development of chondrogenesis, which may delay fetal articular cartilage development and increase susceptibility to osteoarthritis in adults."3.88Prenatal caffeine exprosure increases adult female offspring rat's susceptibility to osteoarthritis via low-functional programming of cartilage IGF-1 with histone acetylation. ( Chen, L; Li, J; Lu, K; Magdalou, J; Ni, Q; Tan, Y; Wang, H; Zhao, Z, 2018)
"Epidemiologic investigations suggest that excessive intake of caffeine during pregnancy is one of the risk factors for osteoporosis in adult offspring."3.88Intrauterine Programming of Glucocorticoid-Insulin-Like Growth Factor-1 Axis-Mediated Developmental Origin of Osteoporosis Susceptibility in Female Offspring Rats with Prenatal Caffeine Exposure. ( Chen, L; Jiang, H; Magdalou, J; Qin, J; Shangguan, Y; Tan, Y; Wang, H; Wen, Y, 2018)
" The objective of this study was to investigate the association between hypodontia and common environmental risk factors, such as maternal smoking and alcohol and caffeine consumption during pregnancy."3.85Maternal Smoking during Pregnancy Is Associated with Offspring Hypodontia. ( Al-Ani, AH; Antoun, JS; Farella, M; Merriman, TR; Thomson, WM, 2017)
"We examined the association of hypospadias risk with maternal smoking and consumption of alcohol and caffeine."3.85Maternal Smoking, Alcohol, and Caffeine Exposures and Risk of Hypospadias. ( Carmichael, SL; Ma, C; Shaw, GM, 2017)
"To examine the association between maternal caffeine consumption from coffee and tea during pregnancy and offspring behavioral disorders."3.85Maternal Caffeine Consumption during Pregnancy and Behavioral Disorders in 11-Year-Old Offspring: A Danish National Birth Cohort Study. ( Bech, BH; Hvolgaard Mikkelsen, S; Niclasen, J; Obel, C; Olsen, J, 2017)
"This study aimed to investigate the association between prenatal caffeine ingestion (PCI) and risk of postnatal pulmonary inflammation."3.85Prenatal caffeine ingestion increases susceptibility to pulmonary inflammation in adult female rat offspring. ( Chen, T; Hou, LF; Liu, HX; Liu, S; Ping, J; Qu, W; Wen, X; Yan, HY, 2017)
"Objective To investigate the association between maternal caffeine intake during pregnancy and infant anthropometric measurements at age 3 and 6 months."3.85Caffeine Intake During Pregnancy in Different Intrauterine Environments and its Association with Infant Anthropometric Measurements at 3 and 6 Months of Age. ( Bernardi, JR; Bosa, VL; da Silva, CH; de Brito, ML; de Medeiros, TS; Goldani, MZ, 2017)
"Evidence from animal studies suggests maternal caffeine intake during pregnancy has detrimental effects on subsequent brain development in offspring."3.83Prenatal Caffeine Exposure and Child IQ at Age 5.5 Years: The EDEN Mother-Child Cohort. ( Bernard, JY; Bouvard, MP; De Agostini, M; Forhan, A; Galéra, C; Heude, B; Lioret, S; Melchior, M; van der Waerden, J, 2016)
"The associations of maternal caffeine intake during pregnancy with offspring growth patterns and body fat and insulin levels at school age were examined."3.83Maternal caffeine intake during pregnancy, early growth, and body fat distribution at school age. ( Franco, OH; Gaillard, R; Gishti, O; Hofman, A; Jaddoe, VW; Voerman, E, 2016)
"Postnatal administration of caffeine may reduce the risk of cerebral palsy (CP) in vulnerable low-birth-weight neonates."3.83Intake of Caffeinated Soft Drinks before and during Pregnancy, but Not Total Caffeine Intake, Is Associated with Increased Cerebral Palsy Risk in the Norwegian Mother and Child Cohort Study. ( Brantsæter, AL; Eichelberger, KY; Lie, RT; Meltzer, HM; Moster, D; Stoltenberg, C; Strandberg-Larsen, K; Tollånes, MC; Wilcox, AJ, 2016)
"Studies evaluating caffeine intake during pregnancy and long-term outcomes, such as the child's neurobehaviour, are still scarce and their results are inconsistent."3.83Caffeine consumption during pregnancy and ADHD at the age of 11 years: a birth cohort study. ( Anselmi, L; Del-Ponte, B; Matijasevich, A; Munhoz, TN; Santos, IS; Tovo-Rodrigues, L, 2016)
"This study does not support an increased risk of childhood obesity with increasing maternal caffeine consumption during pregnancy."3.81Maternal serum paraxanthine during pregnancy and offspring body mass index at ages 4 and 7 years. ( Keim, SA; Klebanoff, MA, 2015)
"Prenatal caffeine exposure (PCE) alters the hypothalamic-pituitary-adrenocortical (HPA) axis-associated neuroendocrine metabolic programming and induces an increased susceptibility to metabolic syndrome (MS) in intrauterine growth retardation (IUGR) offspring rats."3.81Gender-specific increase in susceptibility to metabolic syndrome of offspring rats after prenatal caffeine exposure with post-weaning high-fat diet. ( Chen, L; Guo, Y; He, Z; Li, J; Luo, H; Ma, L; Magdalou, J; Wang, H; Wu, Y; Zhang, L, 2015)
"Although caffeine is commonly consumed during pregnancy, there are few reports on the association of in utero caffeine exposure with offspring cognition or behavior during childhood."3.81Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age. ( Keim, SA; Klebanoff, MA, 2015)
"To investigate the effects of the maternal caffeine consumption during pregnancy to adult male testis mice offspring."3.80The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption. ( Aiceles, V; Alves-Pereira, JL; Cavalcante, FS; Faria, TS; Moraes, Dde F; Ramos, Cda F, 2014)
"Maternal caffeine exposure may be one of the causes for intrauterine growth retardation and low birth weight (LBW), and increased risk of type 2 diabetes mellitus (T2DM) in the adulthood has been associated with LBW."3.80Maternal caffeine exposure impairs insulin secretion by pancreatic β-cells and increases the risk of type II diabetes mellitus in offspring. ( Chan, HC; Chen, H; Guo, J; Huang, X; Jiang, X; Sha, J; Sun, T; Wang, F; Xu, Z; Zhang, J; Zhang, X, 2014)
"We hypothesized that caffeine improves respiratory function via an anti-inflammatory effect in lungs of a lipopolysaccharide (LPS)-induced pro-inflammatory amnionitis rat pup model."3.80Anti-inflammatory effect of caffeine is associated with improved lung function after lipopolysaccharide-induced amnionitis. ( Balan, KV; Jafri, A; Kc, P; Köroğlu, OA; MacFarlane, PM; Martin, RJ; Zenebe, WJ, 2014)
" All but 1 mother consumed caffeine in pregnancy."3.78Maternal caffeine consumption and infant nighttime waking: prospective cohort study. ( Domingues, MR; Matijasevich, A; Santos, IS, 2012)
"Human studies that have investigated the association between caffeine intake during pregnancy and offspring's behavioral outcomes are scant and inconclusive."3.78Caffeine intake during pregnancy and risk of problem behavior in 5- to 6-year-old children. ( Hofland, L; Koot, HM; Loomans, EM; Van den Bergh, BR; van der Stelt, O; van der Wal, MF; Vrijkotte, TG, 2012)
" Additionally, the mothers of these infants were asked to identify their smoking habits and/or caffeine consumption during pregnancy through face-to-face interviews."3.76A study on neonatal factors and eruption time of primary teeth. ( Aktoren, O; Gokcay, G; Guven, Y; Tuna, EB, 2010)
" Maternal consumption of coffee and other caffeine-containing beverages in early pregnancy was recorded shortly after birth."3.75Maternal consumption of coffee and caffeine-containing beverages and oral clefts: a population-based case-control study in Norway. ( Andersen, LF; Drevon, CA; Johansen, AM; Lie, RT; Wilcox, AJ, 2009)
"There are lingering concerns about caffeine consumption during pregnancy or the early postnatal period, partly because there may be long-lasting behavioral changes after caffeine exposure early in life."3.74Perinatal caffeine, acting on maternal adenosine A(1) receptors, causes long-lasting behavioral changes in mouse offspring. ( Björklund, O; Fredholm, BB; Kahlström, J; Salmi, P, 2008)
"No significant associations were seen between intrauterine exposure to alcohol or caffeine and a diagnosis of endometriosis."3.74Intrauterine exposures and risk of endometriosis. ( Buck Louis, GM; Hediger, ML; Peña, JB, 2007)
"The aim of this work was to study whether caffeine or theophylline chronically consumed during pregnancy affect inhibitory adenylyl cyclase pathway mediated by adenosine, in rat brain of both mothers and full-term fetuses."3.73Chronic caffeine or theophylline intake during pregnancy inhibits A1 receptor function in the rat brain. ( Albasanz, JL; León, D; Martín, M; Ruíz, MA, 2005)
"To test the hypothesis that, in women with type 1 diabetes, prenatal smoking and caffeine consumption during pregnancy are associated with an increased risk of adverse maternal and perinatal outcomes."3.72Consequences of smoking and caffeine consumption during pregnancy in women with type 1 diabetes. ( Buncher, CR; Kalkwarf, H; Khoury, JC; Khoury, PR; McElvy, S; Miodovnik, M; Sibai, B, 2004)
"Excessive maternal caffeine exposure during pregnancy had cataractogenic effects on developing crystalline lenses in newborn rat eyes, both macroscopically and histopathologically."3.72Excessive maternal caffeine exposure during pregnancy is cataractogenic for neonatal crystalline lenses in rats: a biomicroscopic and histopathologic study. ( Alasehirli, B; Cengiz, B; Evereklioglu, C; Güldür, E; Pirbudak, L; Sari, I, 2004)
"To examine the association between maternal caffeine consumption during pregnancy and the risk of sudden infant death syndrome (SIDS)."3.70Heavy caffeine intake in pregnancy and sudden infant death syndrome. New Zealand Cot Death Study Group. ( Ford, RP; Mitchell, EA; Schluter, PJ; Scragg, R; Stewart, AW; Taylor, BJ, 1998)
"The crude ORs for caffeine consumption > 800 mg/24 hours both during and after pregnancy were significantly raised: 3."3.70Caffeine and alcohol as risk factors for sudden infant death syndrome. Nordic Epidemiological SIDS Study. ( Alm, B; Helweg-Larsen, K; Irgens, LM; Lagercrantz, H; Norvenius, G; Oyen, N; Skjaerven, R; Wennergren, G, 1999)
"There is considerable concern over the widespread use of caffeine during and after pregnancy."3.69The effect of long term caffeine treatment on hypoxic-ischemic brain damage in the neonate. ( Adén, U; Bona, E; Fredholm, BB; Hagberg, H, 1995)
" Alcohol and caffeine consumption by the mothers during pregnancy were both significantly associated with elevated IgE concentration."3.69Several genetic and environmental factors influence cord blood IgE concentration. ( Bjerke, T; Hedegaard, M; Henriksen, TB; Nielsen, BW; Schiøtz, PO, 1994)
"35 mg/ml of caffeine prior to and throughout pregnancy."3.69In utero caffeine exposure affects feeding pattern and variable ratio performance in infant monkeys. ( Gilbert, SG; Rice, DC, 1994)
"In this study, fetal joint abnormalities caused by cytosine arabinoside, caffeine, sodium salicylate, and retinyl acetate administration during pregnancy, were investigated."3.69Demonstration of congenital anomalies in the joints of the forelimbs and hindlimbs caused by several pharmacological agents. ( Erdoğan, D; Kadioğlu, D; Peker, T, 1996)
"The present study was designed to investigate the mechanism(s) underlying previously observed birth weight differences found in the first litter of the second (F2) generation bred from caffeine-exposed F1 females."3.68Caffeine-mediated effects on reproductive health over two generations in rats. ( Claassens, R; Pollard, I, 1992)
"In this manuscript it is demonstrated that caffeine when administered to the rat (30 mg/kg per day) during pregnancy affected certain aspects of normal sexual differentiation of the fetal gonads."3.68Influence of caffeine administered during pregnancy on the early differentiation of fetal rat ovaries and testes. ( Magre, S; Pollard, I; Williamson, S, 1990)
"Caffeine, when administered in moderate (30 mg/kg X d) or high (60 mg/kg X d) doses during pregnancy, was shown to cause significant fetal growth retardation of both sexes."3.67Effects of caffeine administered during pregnancy on fetal development and subsequent function in the adult rat: prolonged effects on a second generation. ( Jabbour, H; Mehrabani, PA; Pollard, I, 1987)
"To evaluate the relationship of antecedent maternal smoking and caffeine consumption habits on the occurrence of apnea in their offspring, rates for central and obstructive apnea were analyzed in a cohort of mother-infant pairs."3.67Effects of maternal smoking and caffeine habits on infantile apnea: a retrospective study. ( Bendell, D; Duke, JC; Mattice, CD; McCaffree, MA; Orr, WC; Toubas, PL, 1986)
"Reduced offspring growth was found following introduction of caffeine into the normal diet of rats during pregnancy and lactation."3.66The effects of maternal carbohydrate (sucrose) supplementation on the growth of offspring of pregnancies with habitual caffeine consumption. ( Court, JM; Dunlop, M; Larkins, RG, 1981)
"Caffeine is a widespread natural methylaxanthine which easily crosses the placenta."2.41[Teratogenic and embryotoxic effects of caffeine: facts and hypotheses]. ( Burdan, F, 2000)
"Epidemiological studies revealed that prenatal caffeine exposure (PCE) is associated with adverse gestational outcomes and susceptibility to chronic diseases in offspring, yet the effects of PCE on glomerulosclerosis susceptibility in adult female offspring and its intergenerational transmission remain to be further investigated."1.72Prenatal caffeine exposure induced renal developmental toxicity and transgenerational effect in rat offspring. ( Ao, Y; Hu, S; Li, B; Sun, Z; Wang, H; Xia, Z; Xiong, Y; Zhao, X, 2022)
"Caffeine powder was dissolved in distilled water."1.62Experimental study of pre- and postnatal caffeine exposure and its observable effects on selected neurotransmitters and behavioural attributes at puberty : Caffeine exposure and its observable effects on selected neurotranmitters and behaviour. ( Adefule, KA; Ajibade, TP; Fabiyi, OS; Ogunnaike, PO; Olanrewaju, JA; Olatunji, SY; Owolabi, JO; Oyewumi, S; Shallie, PD, 2021)
"Caffeine has developmental toxicity."1.62Prenatal caffeine exposure caused H-type blood vessel-related long bone dysplasia via miR375/CTGF signaling. ( Chen, L; He, H; Liu, L; Luo, H; Shangguan, Y; Wang, H; Wen, Y; Xie, X, 2021)
"Osteoarthritis is associated with intrauterine growth retardation (IUGR) and abnormal glucose metabolism."1.56Programming changes in GLUT1 mediated the accumulation of AGEs and matrix degradation in the articular cartilage of female adult rats after prenatal caffeine exposure. ( Hui, H; Hui, W; Liang, L; Liao-Bin, C; Lin-Long, W; Qing-Xian, L; Yi-Zhong, W, 2020)
"In the present study, a rat model of intrauterine growth retardation (IUGR) was established by PCE, and offspring were sacrificed."1.51Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure. ( He, Z; Huang, H; Magdalou, J; Wang, H; Yuan, C; Zhang, J; Zhu, C, 2019)
"This study aimed to verify the toxic effects of prenatal caffeine exposure (PCE) on the podocyte development in male offspring, and to explore the underlying intrauterine programming mechanisms."1.51Decreased H3K9ac level of KLF4 mediates podocyte developmental toxicity induced by prenatal caffeine exposure in male offspring rats. ( Ao, Y; Chen, H; Cheng, H; He, H; Li, B; Wang, H; Zhao, X; Zhu, Y, 2019)
"Furthermore, caffeine treatment during pregnancy and lactation causes long-term behavioral changes in the mice offspring that manifest later in life."1.43Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine. ( Côrtes, Wda S; da Conceição, RR; da Rocha, FF; da Silva-Almeida, C; da Silveira, AL; de Azevedo Cruz Seara, F; Laureano-Melo, R; Marinho, BG; Reis, LC, 2016)
" This association demonstrated a dose-response relationship: OR=1."1.42Maternal caffeine intake during pregnancy and risk of obesity in offspring: a prospective cohort study. ( Ferber, JR; Li, DK; Odouli, R, 2015)
"Caffeine treatment increased both RR and NG latency times."1.42Maternal caffeine exposure alters neuromotor development and hippocampus acetylcholinesterase activity in rat offspring. ( Bogo, MR; Bonan, CD; Capiotti, KM; Caumo, W; Da Silva, RS; De Oliveira, C; Kist, LW; Medeiros, LF; Scarabelot, VL; Souza, A; Souza, AC; Torres, IL, 2015)
"Caffeine was investigated for its possible fetal programming effects on reproductive function of male offspring."1.42Effects of Oral Maternal Administration of Caffeine on Reproductive Functions of Male Offspring of Wistar Rats. ( Akindele, OO; Ogunwole, E; Oluwole, OF; Raji, Y; Salami, SA, 2015)
"Severe NAFLD appeared with higher Kleiner scores."1.40Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring. ( Chen, L; Huang, H; Liu, Y; Liu, Z; Ping, J; Shen, L; Wang, H; Wang, L; Wu, Y; Zhang, L, 2014)
"This caffeine treatment results in serum levels equivalent to the consumption of 2-4 cups of coffee in humans."1.40Embryonic caffeine exposure acts via A1 adenosine receptors to alter adult cardiac function and DNA methylation in mice. ( Buscariollo, DL; Fang, X; Greenwood, V; Rivkees, SA; Wendler, CC; Xue, H, 2014)
"Caffeine is a definite factor of intrauterine growth retardation (IUGR)."1.38A hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion. ( Chen, LB; Lei, YY; Liu, F; Liu, J; Liu, YS; Magdalou, J; Ping, J; Qin, J; Shen, L; Wang, H; Wu, Y; Xu, D; Zhang, C, 2012)
"Caffeine is a widely used psychostimulant freely crossing the placental barrier."1.35Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar hypoxia in newborn rats and adenosine A2A and GABA A receptor mRNA transcription. ( Guénin, S; Larnicol, N; Perrin, Y; Picard, N, 2008)
"Caffeine was dissolved in normal saline, so it was used as a control."1.35Embryonic caffeine exposure induces adverse effects in adulthood. ( Busovsky-McNeal, M; Ghatpande, S; Kalinowski, A; Rivkees, SA; Russell, KS; Wendler, CC, 2009)
"In caffeine group, an increase in the baseline Rf in presence of the pons and no change in medullary-spinal cord preparations have been observed."1.32Involvement of adenosinergic A1 systems in the occurrence of respiratory perturbations encountered in newborns following an in utero caffeine exposure. a study on brainstem-spinal cord preparations isolated from newborn rats. ( Bodineau, L; Frugière, A; Gaytan, S; Gros, F; Saadani-Makki, F, 2004)
"Caffeine treatment had no significant effect on adenosine A1 receptors or on A1 receptor mRNA."1.31Maternal caffeine intake has minor effects on adenosine receptor ontogeny in the rat brain. ( Adén, U; Fredholm, BB; Herlenius, E; Tang, LQ, 2000)
" Prenatal caffeine at the dosage we have used in combination with malnutrition may produce lasting metabolic alterations in the nervous system related to the emergence of suckling behavior and general motor activity."1.29Combined effects of caffeine and malnutrition during pregnancy on suckling behavior in newborn rats. ( Joseph, F; Nakamoto, T; Narayanan, CH; Saito, T; Yoshino, S, 1994)
"A caffeine tablet was implanted subcutaneously in the experimental group and a placebo tablet in the control group."1.29The effect of prenatal caffeine exposure on the enamel surface of the first molars of newborn rats. ( Falster, AU; Hashimoto, K; Joseph, F; Nakamoto, T; Simmons, WB; Yoshino, S, 1993)
"Experiments examining seizure sensitivity were conducted on adult male offspring exposed to diazepam at 1."1.28Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex. ( Bitran, D; Kellogg, CK; Primus, RJ, 1991)
"Caffeine has been associated with a number of reproductive and developmental effects in animals and humans."1.28Somatic development of the infant monkey following in utero exposure to caffeine. ( Gilbert, SG; Rice, DC, 1991)

Research

Studies (165)

TimeframeStudies, this research(%)All Research%
pre-199018 (10.91)18.7374
1990's31 (18.79)18.2507
2000's24 (14.55)29.6817
2010's65 (39.39)24.3611
2020's27 (16.36)2.80

Authors

AuthorsStudies
Owolabi, JO1
Adefule, KA1
Shallie, PD1
Fabiyi, OS1
Olatunji, SY1
Olanrewaju, JA1
Ajibade, TP1
Oyewumi, S1
Ogunnaike, PO1
He, Z8
Zhang, J4
Chen, G3
Cao, J1
Chen, Y2
Ai, C2
Wang, H36
Haan, E2
Sallis, HM2
Zuccolo, L2
Labrecque, J1
Ystrom, E1
Reichborn-Kjennerud, T1
Andreassen, O1
Havdahl, A1
Munafò, MR2
Westmoreland, KE1
Schellhas, L1
Taylor, G1
Zhao, X2
Li, B4
Xiong, Y1
Xia, Z1
Hu, S5
Sun, Z2
Ao, Y3
Magenis, ML1
Damiani, AP1
Franca, IB1
de Marcos, PS1
Effting, PS1
Muller, AP1
de Bem Silveira, G1
Borges Correa, MEA1
Medeiros, EB1
Silveira, PCL1
Budni, J1
Boeck, CR1
de Andrade, VM1
Lu, M1
He, X2
Jiao, Z1
Hu, Z1
Guo, Z2
Dai, S1
Xu, D11
Liu, Y6
Zhang, C5
Zhu, J2
Qu, H2
Zhou, S2
Chen, M2
Chen, L18
Zhang, D1
Huang, H5
Lu, X1
Shi, H1
Liu, K2
Guo, X2
Zhang, R2
Yavuz, M1
Albayrak, N1
Özgür, M1
Gülçebi İdriz Oğlu, M1
Çavdar, S1
Onat, F1
Zhang, Q2
Huang, S1
Zhang, H1
Wang, W1
Hua, W1
Bi, H1
Qing-Xian, L1
Lin-Long, W1
Yi-Zhong, W1
Liang, L1
Hui, H1
Liao-Bin, C1
Hui, W1
Qian, J1
Chen, Q1
Ward, SM1
Duan, E1
Zhang, Y1
Li, N2
Shi, R2
Tang, J1
Zhang, W3
Liu, B1
Chen, X1
Gao, Q1
Li, X1
Sun, M2
Xu, Z3
Xie, X2
Tan, Y6
Xiao, H4
Wen, Y5
Magdalou, J14
Voerman, E2
Jaddoe, VW2
Hulst, ME1
Oei, EH1
Gaillard, R2
Lamy, S1
Houivet, E1
Benichou, J1
Marret, S1
Thibaut, F1
Li, J4
Luo, H9
Ni, Q2
He, C2
Berglundh, S1
Vollrath, M1
Brantsæter, AL3
Brandlistuen, R1
Solé-Navais, P1
Jacobsson, B2
Sengpiel, V2
Zhao, Z2
Qin, J4
Pei, L1
Wu, Z1
Shangguan, Y5
Stoltz, JF1
Eubanks, AA1
Nobles, CJ1
Hill, MJ1
DeCherney, AH1
Kim, K1
Sjaarda, LA1
Perkins, NJ1
Ye, A1
Zolton, JR1
Silver, RM1
Schisterman, EF1
Mumford, SL1
Yilmaz, F1
Tekmen, I1
Baptiste-Roberts, K1
Leviton, A2
Alhowail, A1
Aldubayan, M1
Christensen, ZP1
Freedman, EG1
Foxe, JJ1
He, H2
Liu, L3
Lv, F3
Fan, G1
Wan, Y1
Ni, Y1
Huang, J1
Manza, P1
Volkow, ND1
Al-Ani, AH1
Antoun, JS1
Thomson, WM1
Merriman, TR1
Farella, M1
Fazeli, W1
Zappettini, S1
Marguet, SL1
Grendel, J1
Esclapez, M1
Bernard, C1
Isbrandt, D1
Pei, LG3
Yuan, C5
Guo, YT1
Kou, H3
Xia, LP1
Zhang, L8
Yan, YE1
Carmichael, SL1
Ma, C1
Shaw, GM1
Hvolgaard Mikkelsen, S1
Obel, C3
Olsen, J3
Niclasen, J1
Bech, BH2
Wang, GH2
Shi, C1
Guo, Y3
Wu, DF1
Liu, HX3
Hou, LF2
Chen, T2
Qu, W3
Liu, S1
Yan, HY2
Wen, X3
Ping, J6
Jiang, H2
Pan, Z2
Tie, K1
Deng, Y1
Ding, Y1
Zhu, C2
Lei, Y1
Si, C1
Hu, D1
Lu, J1
Cheng, S1
Duan, F1
Miyake, Y1
Tanaka, K1
Okubo, H1
Sasaki, S1
Arakawa, M1
Papadopoulou, E1
Botton, J1
Haugen, M1
Alexander, J1
Meltzer, HM2
Bacelis, J1
Elfvin, A1
Luo, HW1
Hu, W2
Hu, SW1
Yu, H2
Chen, LB2
Wu, Y6
Wu, DM1
Ma, LP1
Lu, K1
Li, Y1
Hu, H1
Xia, L2
Xu, Y1
Zhao, WH1
Kobayashi, S1
Sata, F1
Murata, K1
Saijo, Y1
Araki, A1
Miyashita, C1
Itoh, S1
Minatoya, M1
Yamazaki, K1
Ait Bamai, Y1
Kishi, R1
Chen, LW2
Murrin, CM1
Mehegan, J1
Kelleher, CC1
Phillips, CM1
Liu, M1
Zou, YF1
Luo, DJ1
Zhong, S1
Zhu, Y1
Chen, H2
Cheng, H1
He, B1
Wang, G1
Wang, L2
Shen, L3
Liu, Z1
Deng, Z1
Ma, L2
Cavalcante, FS1
Aiceles, V1
Moraes, Dde F1
Alves-Pereira, JL1
Faria, TS1
Ramos, Cda F1
Buscariollo, DL1
Fang, X1
Greenwood, V1
Xue, H1
Rivkees, SA2
Wendler, CC2
Merritt, T1
Mazela, J1
Merritt, A1
Mioranzza, S1
Nunes, F1
Marques, DM1
Fioreze, GT1
Rocha, AS1
Botton, PH1
Costa, MS1
Porciúncula, LO1
Sun, T1
Guo, J1
Zhang, X1
Jiang, X1
Wang, F1
Huang, X1
Sha, J1
Chan, HC1
Köroğlu, OA1
MacFarlane, PM1
Balan, KV1
Zenebe, WJ1
Jafri, A1
Martin, RJ1
Kc, P1
Neelakantan, N1
Chong, MF1
Pan, A1
van Dam, RM1
Li, DK1
Ferber, JR1
Odouli, R1
Souza, AC1
Souza, A1
Medeiros, LF1
De Oliveira, C1
Scarabelot, VL1
Da Silva, RS2
Bogo, MR1
Capiotti, KM1
Kist, LW1
Bonan, CD2
Caumo, W1
Torres, IL1
Bracken, MB1
Klebanoff, MA2
Keim, SA2
James, JE1
Silva, Bdel P1
Anselmi, L2
Schmidt, V1
Santos, IS3
Zuo, N1
Yang, S1
Galéra, C1
Bernard, JY1
van der Waerden, J1
Bouvard, MP1
Lioret, S1
Forhan, A1
De Agostini, M1
Melchior, M1
Heude, B1
Cao, H1
Gishti, O1
Hofman, A1
Franco, OH1
Laureano-Melo, R1
da Silveira, AL1
de Azevedo Cruz Seara, F1
da Conceição, RR1
da Silva-Almeida, C1
Marinho, BG1
da Rocha, FF1
Reis, LC1
Côrtes, Wda S1
Tollånes, MC1
Strandberg-Larsen, K1
Eichelberger, KY1
Moster, D1
Lie, RT2
Stoltenberg, C1
Wilcox, AJ2
Ogunwole, E1
Akindele, OO1
Oluwole, OF1
Salami, SA1
Raji, Y1
Del-Ponte, B1
Tovo-Rodrigues, L1
Munhoz, TN1
Matijasevich, A2
de Medeiros, TS1
Bernardi, JR1
de Brito, ML1
Bosa, VL1
Goldani, MZ1
da Silva, CH1
Picard, N1
Guénin, S1
Larnicol, N1
Perrin, Y1
Ramlau-Hansen, CH1
Thulstrup, AM1
Bonde, JP1
Linnet, KM2
Wisborg, K2
Secher, NJ1
Thomsen, PH2
Dalsgaard, S2
Henriksen, TB3
Björklund, O2
Halldner-Henriksson, L1
Yang, J1
Eriksson, TM1
Jacobson, MA1
Daré, E1
Fredholm, BB4
Busovsky-McNeal, M1
Ghatpande, S1
Kalinowski, A1
Russell, KS1
Kahlström, J1
Salmi, P1
Miller, EA1
Manning, SE1
Rasmussen, SA1
Reefhuis, J1
Honein, MA1
Johansen, AM1
Andersen, LF1
Drevon, CA1
Soellner, DE1
Grandys, T1
Nuñez, JL1
Lorenzo, AM1
León, D3
Castillo, CA1
Ruiz, MA3
Albasanz, JL3
Martín, M3
Bekkhus, M1
Skjøthaug, T1
Nordhagen, R1
Borge, AI1
Aktoren, O1
Tuna, EB1
Guven, Y1
Gokcay, G1
Adén, U3
Brent, RL1
Christian, MS1
Diener, RM1
Domingues, MR1
Loomans, EM1
Hofland, L1
van der Stelt, O1
van der Wal, MF1
Koot, HM1
Van den Bergh, BR1
Vrijkotte, TG1
Liu, F1
Liu, YS1
Lei, YY1
Liu, J1
Rodriguez, A1
Kotimaa, A1
Moilanen, I1
Jarvelin, MR1
Tsoi, L1
Frey, U1
Kuehni, C1
Roiha, H1
Cernelc, M1
Reinmann, B1
Wildhaber, JH1
Hall, GL1
Khoury, JC1
Miodovnik, M1
Buncher, CR1
Kalkwarf, H1
McElvy, S1
Khoury, PR1
Sibai, B1
Saadani-Makki, F2
Frugière, A2
Gros, F1
Gaytan, S1
Bodineau, L2
Evereklioglu, C1
Güldür, E1
Alasehirli, B1
Cengiz, B1
Sari, I1
Pirbudak, L1
Hoffman, A1
de Souza, DO1
Lara, DR1
Iglesias, I1
Jullien, H1
Martín, I1
López-Vílchez, MA1
Mur, A1
García-Algar, O1
Rossi, S1
Marchei, E1
Pichini, S1
Buck Louis, GM1
Hediger, ML1
Peña, JB1
Marangos, PJ1
Boulenger, JP1
Patel, J1
Streissguth, AP1
Barr, HM1
Martin, DC1
Hill, LM1
Kleinberg, F1
Nakamoto, T9
Shaye, R1
Lombardelli, G1
Balduini, W1
Feduzi, A1
Peruzzi, G1
Cattabeni, F1
Butcher, RE1
Vorhees, CV1
Wootten, V1
Sinton, CM1
Valatx, JL1
Jouvet, M1
Skalko, RG1
Kwasigroch, TE1
Concannon, JT1
Braughler, JM1
Schechter, MD1
Dunlop, M1
Court, JM1
Larkins, RG1
Bona, E1
Hagberg, H1
Barkovich, AJ1
Rowley, H1
Bollen, A1
Golding, J2
Sasahara, H2
Cheuk, SL1
Wink, CS1
Hashimoto, K2
Rossowska, MJ2
Yoshino, S2
Narayanan, CH1
Joseph, F2
Saito, T1
Bjerke, T1
Hedegaard, M1
Nielsen, BW1
Schiøtz, PO1
Gilbert, SG2
Rice, DC2
Nehlig, A1
Debry, G1
Falster, AU1
Simmons, WB1
Hadeed, A1
Siegel, S1
Fisher, CE1
Hughes, RN3
Lafontaine, A1
Noirfalise, A1
Case, TS1
Saltzman, MJ1
Cheuk, J1
Yazdani, M2
Sadeghpour, A1
Albrecht, D1
Brown, DW1
Erdoğan, D1
Kadioğlu, D1
Peker, T1
Karthikeyan, G1
Ford, RP1
Schluter, PJ1
Mitchell, EA1
Taylor, BJ1
Scragg, R1
Stewart, AW1
Engle, PL1
VasDias, T1
Howard, I1
Romero-Abal, ME1
Quan de Serrano, J1
Bulux, J1
Solomons, NW1
Dewey, KG1
Alm, B1
Wennergren, G1
Norvenius, G1
Skjaerven, R1
Oyen, N1
Helweg-Larsen, K1
Lagercrantz, H1
Irgens, LM1
Herlenius, E1
Tang, LQ1
Burdan, F2
Dews, PB1
Wenger, GR1
Pollard, I3
Claassens, R1
Bitran, D1
Primus, RJ1
Kellogg, CK1
Pejtsik, B1
Pintér, J1
Horváth, M1
Hadnagy, J1
Roy, G1
Gottschalk, SB1
Rossowska, M1
Beveridge, IJ2
Williamson, S1
Magre, S1
Schneider, PE1
Miller, HI2
Barone, JJ1
Grice, HC1
Yamano, H1
Sobotka, TJ1
Pohorecky, LA1
Roberts, P1
Cotler, S1
Carbone, JJ1
Grimm, VE1
Frieder, B1
Jabbour, H1
Mehrabani, PA1
Temples, TE1
Geoffray, DJ1
Hartman, AD1
Toubas, PL1
Duke, JC1
McCaffree, MA1
Mattice, CD1
Bendell, D1
Orr, WC1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"Influence of Espresso on Adsorption of Orally Administrated Myo-inositol in Humans"[NCT01244399]12 participants (Actual)Observational2010-11-30Completed
Is the Exhaled Nitric Oxide in Infants a Predictive Marker of Asthma?[NCT01239199]86 participants (Actual)Interventional2010-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

19 reviews available for caffeine and Delayed Effects, Prenatal Exposure

ArticleYear
Prenatal smoking, alcohol and caffeine exposure and offspring externalizing disorders: a systematic review and meta-analysis.
    Addiction (Abingdon, England), 2022, Volume: 117, Issue:10

    Topics: Attention Deficit Disorder with Hyperactivity; Caffeine; Conduct Disorder; Ethanol; Female; Humans;

2022
Paternal Nicotine/Ethanol/Caffeine Mixed Exposure Induces Offspring Rat Dysplasia and Its Potential "GC-IGF1" Programming Mechanism.
    International journal of molecular sciences, 2022, Dec-01, Volume: 23, Issue:23

    Topics: Animals; Caffeine; Corticosterone; Ethanol; Female; Hypothalamo-Hypophyseal System; Insulin-Like Gro

2022
Paternal Nicotine/Ethanol/Caffeine Mixed Exposure Induces Offspring Rat Dysplasia and Its Potential "GC-IGF1" Programming Mechanism.
    International journal of molecular sciences, 2022, Dec-01, Volume: 23, Issue:23

    Topics: Animals; Caffeine; Corticosterone; Ethanol; Female; Hypothalamo-Hypophyseal System; Insulin-Like Gro

2022
Paternal Nicotine/Ethanol/Caffeine Mixed Exposure Induces Offspring Rat Dysplasia and Its Potential "GC-IGF1" Programming Mechanism.
    International journal of molecular sciences, 2022, Dec-01, Volume: 23, Issue:23

    Topics: Animals; Caffeine; Corticosterone; Ethanol; Female; Hypothalamo-Hypophyseal System; Insulin-Like Gro

2022
Paternal Nicotine/Ethanol/Caffeine Mixed Exposure Induces Offspring Rat Dysplasia and Its Potential "GC-IGF1" Programming Mechanism.
    International journal of molecular sciences, 2022, Dec-01, Volume: 23, Issue:23

    Topics: Animals; Caffeine; Corticosterone; Ethanol; Female; Hypothalamo-Hypophyseal System; Insulin-Like Gro

2022
Impacts of Caffeine during Pregnancy.
    Trends in endocrinology and metabolism: TEM, 2020, Volume: 31, Issue:3

    Topics: Animals; Caffeine; Epigenesis, Genetic; Female; Humans; Maternal Nutritional Physiological Phenomena

2020
Caffeine exposure during pregnancy: Is it safe?
    Seminars in fetal & neonatal medicine, 2020, Volume: 25, Issue:6

    Topics: Caffeine; Central Nervous System Stimulants; Child Development; Female; Humans; Infant, Newborn; Pre

2020
Mechanisms underlying cognitive impairment induced by prenatal caffeine exposure.
    European review for medical and pharmacological sciences, 2020, Volume: 24, Issue:22

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Cognitive Dysfunction; Female; Fetal Developme

2020
Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis.
    BMC medicine, 2014, Sep-19, Volume: 12

    Topics: Birth Weight; Caffeine; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Male; Pregnancy;

2014
[Caffeine consumption during pregnancy and attention deficit hyperactivity disorder (ADHD): a systematic literature review].
    Cadernos de saude publica, 2015, Volume: 31, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Brazil; Caffeine; Central Nervous System Stimulants;

2015
Methylxanthines during pregnancy and early postnatal life.
    Handbook of experimental pharmacology, 2011, Issue:200

    Topics: Animals; Caffeine; Female; Fetus; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, G

2011
Evaluation of the reproductive and developmental risks of caffeine.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2011, Volume: 92, Issue:2

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Caffeine; Congenital Abnormalities; Fem

2011
Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence.
    The American journal of psychiatry, 2003, Volume: 160, Issue:6

    Topics: Adolescent; Adult; Alcohol Drinking; Attention Deficit Disorder with Hyperactivity; Caffeine; Child;

2003
Maternal alcohol use and neonatal habituation assessed with the Brazelton scale.
    Child development, 1983, Volume: 54, Issue:5

    Topics: Adult; Alcohol Drinking; Arousal; Caffeine; Ethanol; Female; Habituation, Psychophysiologic; Humans;

1983
Effects of drugs and chemicals on the fetus and newborn (1).
    Mayo Clinic proceedings, 1984, Volume: 59, Issue:10

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Behavior; Caffeine; Dicyclomine; Doxylamine; Drug

1984
Consequences on the newborn of chronic maternal consumption of coffee during gestation and lactation: a review.
    Journal of the American College of Nutrition, 1994, Volume: 13, Issue:1

    Topics: Behavior; Caffeine; Coffee; Female; Humans; Infant, Newborn; Lactation; Milk, Human; Pregnancy; Pren

1994
Reproduction and caffeine consumption--a literature review.
    Early human development, 1995, Aug-30, Volume: 43, Issue:1

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Administration, Oral; Animals; Caffeine; Chick E

1995
[Should one consider monitoring various products containing caffeine?].
    Revue medicale de Liege, 1996, Volume: 51, Issue:3

    Topics: Beverages; Caffeine; Carcinogens; Cardiovascular System; Central Nervous System; Female; Food; Human

1996
[Teratogenic and embryotoxic effects of caffeine: facts and hypotheses].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2000, Volume: 9, Issue:52

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Humans; Maternal-Fetal Exchange; Pregnancy;

2000
[Teratology, 40 years after the thalidomide tragedy].
    Ginekologia polska, 2001, Volume: 72, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Abortion, Spontaneous; Animals; Caffe

2001
[Relationship between congenital heart disease and various factors affecting pregnancy].
    Orvosi hetilap, 1992, Jan-19, Volume: 133, Issue:3

    Topics: Alcohol Drinking; Caffeine; Contraceptives, Oral, Hormonal; Diagnosis, Computer-Assisted; Female; He

1992
Neurobehavioral effects of prenatal caffeine.
    Annals of the New York Academy of Sciences, 1989, Volume: 562

    Topics: Animals; Behavior, Animal; Caffeine; Female; Humans; Mice; Nervous System; Pregnancy; Prenatal Expos

1989

Trials

2 trials available for caffeine and Delayed Effects, Prenatal Exposure

ArticleYear
Caffeine and fetal growth.
    Indian pediatrics, 1997, Volume: 34, Issue:9

    Topics: Birth Weight; Caffeine; Chromatography, Gas; Embryonic and Fetal Development; Female; Gestational Ag

1997
Effects of discontinuing coffee intake on iron deficient Guatemalan toddlers' cognitive development and sleep.
    Early human development, 1999, Volume: 53, Issue:3

    Topics: Anemia, Iron-Deficiency; Caffeine; Coffee; Cognition; Female; Guatemala; Hemoglobins; Humans; Infant

1999

Other Studies

144 other studies available for caffeine and Delayed Effects, Prenatal Exposure

ArticleYear
Experimental study of pre- and postnatal caffeine exposure and its observable effects on selected neurotransmitters and behavioural attributes at puberty : Caffeine exposure and its observable effects on selected neurotranmitters and behaviour.
    Metabolic brain disease, 2021, Volume: 36, Issue:7

    Topics: Animals; Brain; Caffeine; Central Nervous System Stimulants; Female; Mice; Neurotransmitter Agents;

2021
H19/let-7 axis mediates caffeine exposure during pregnancy induced adrenal dysfunction and its multi-generation inheritance.
    The Science of the total environment, 2021, Oct-20, Volume: 792

    Topics: Animals; Caffeine; Corticosterone; Female; Fetal Growth Retardation; Male; Pregnancy; Prenatal Expos

2021
Prenatal smoking, alcohol and caffeine exposure and maternal-reported attention deficit hyperactivity disorder symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses.
    Addiction (Abingdon, England), 2022, Volume: 117, Issue:5

    Topics: Attention Deficit Disorder with Hyperactivity; Caffeine; Cohort Studies; Female; Humans; Longitudina

2022
Prenatal caffeine exposure induced renal developmental toxicity and transgenerational effect in rat offspring.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2022, Volume: 165

    Topics: Animals; Caffeine; Female; Fetus; Glucocorticoids; Humans; Kidney Diseases; Pregnancy; Prenatal Expo

2022
Behavioral, genetic and biochemical changes in the brain of the offspring of female mice treated with caffeine during pregnancy and lactation.
    Reproductive toxicology (Elmsford, N.Y.), 2022, Volume: 112

    Topics: Animals; Brain; Caffeine; Female; Humans; Lactation; Male; Mice; Pregnancy; Prenatal Exposure Delaye

2022
The upregulation of glutamate decarboxylase 67 against hippocampal excitability damage in male fetal rats by prenatal caffeine exposure.
    Environmental toxicology, 2022, Volume: 37, Issue:11

    Topics: Adenylyl Cyclases; Animals; Brain-Derived Neurotrophic Factor; Caffeine; Colforsin; Female; gamma-Am

2022
Cathepsin D mediates prenatal caffeine exposure-caused NAFLD susceptibility in male rat offspring by regulating autophagy.
    Free radical biology & medicine, 2023, 11-01, Volume: 208

    Topics: Animals; Autophagy; Caffeine; Cathepsin D; Corticosterone; Female; Humans; Male; MicroRNAs; Non-alco

2023
The effect of prenatal and postnatal caffeine exposure on pentylentetrazole induced seizures in the non-epileptic and epileptic offsprings.
    Neuroscience letters, 2019, 11-20, Volume: 713

    Topics: Animals; Brain; Caffeine; Calcium Channels, T-Type; Epilepsy, Absence; Female; Male; Pentylenetetraz

2019
Serum metabolic profile characteristics of offspring rats before and after birth caused by prenatal caffeine exposure.
    Toxicology, 2019, 11-01, Volume: 427

    Topics: Amino Acids; Animals; Caffeine; Female; Fetal Growth Retardation; Lipid Metabolism; Male; Maternal-F

2019
Programming changes in GLUT1 mediated the accumulation of AGEs and matrix degradation in the articular cartilage of female adult rats after prenatal caffeine exposure.
    Pharmacological research, 2020, Volume: 151

    Topics: Animals; Animals, Newborn; Caffeine; Cartilage, Articular; Female; Glucose Transporter Type 1; Glyca

2020
Prenatal caffeine exposure induces down-regulation of the protein kinase A/ryanodine receptor/large-conductance Ca2+-activated K+ pathway in the cerebral arteries of old offspring rats.
    Journal of hypertension, 2020, Volume: 38, Issue:4

    Topics: Animals; Caffeine; Calcium; Cerebral Arteries; Cyclic AMP-Dependent Protein Kinases; Down-Regulation

2020
Subchondral bone dysplasia mediates susceptibility to osteoarthritis in female adult offspring rats induced by prenatal caffeine exposure.
    Toxicology letters, 2020, Mar-15, Volume: 321

    Topics: Age Factors; Animals; Bone Diseases, Developmental; Caffeine; Cartilage, Articular; Cell Differentia

2020
Associations of maternal caffeine intake during pregnancy with abdominal and liver fat deposition in childhood.
    Pediatric obesity, 2020, Volume: 15, Issue:5

    Topics: Abdominal Fat; Adipose Tissue; Adult; Caffeine; Child; Cohort Studies; Female; Humans; Liver; Male;

2020
Caffeine use during pregnancy: prevalence of use and newborn consequences in a cohort of French pregnant women.
    European archives of psychiatry and clinical neuroscience, 2021, Volume: 271, Issue:5

    Topics: Caffeine; Cohort Studies; Female; France; Humans; Infant, Newborn; Pregnancy; Prenatal Exposure Dela

2021
GR/HDAC2/TGFβR1 pathway contributes to prenatal caffeine induced-osteoarthritis susceptibility in male adult offspring rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020, Volume: 140

    Topics: Animals; Caffeine; Disease Susceptibility; Female; Histone Deacetylase 2; Male; Osteoarthritis; Preg

2020
Maternal caffeine intake during pregnancy and child neurodevelopment up to eight years of age-Results from the Norwegian Mother, Father and Child Cohort Study.
    European journal of nutrition, 2021, Volume: 60, Issue:2

    Topics: Caffeine; Child; Child Development; Cohort Studies; Fathers; Female; Humans; Language; Male; Mothers

2021
Articular damages in multi-generational female offspring due to prenatal caffeine exposure correlates with H3K9 deacetylation of TGFβ signaling pathway.
    Toxicology, 2020, Volume: 442

    Topics: Animals; Caffeine; Cartilage Diseases; Cartilage, Articular; Central Nervous System Stimulants; Chon

2020
The low-expression programming of 11β-HSD2 mediates osteoporosis susceptibility induced by prenatal caffeine exposure in male offspring rats.
    British journal of pharmacology, 2020, Volume: 177, Issue:20

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; 11-beta-Hydroxysteroid Dehydrogenases; Animals; Caffein

2020
Recalled maternal lifestyle behaviors associated with anti-müllerian hormone of adult female offspring.
    Reproductive toxicology (Elmsford, N.Y.), 2020, Volume: 98

    Topics: Adolescent; Adult; Alcohol Drinking; Anti-Mullerian Hormone; Caffeine; Female; Humans; Life Style; M

2020
The dosage-dependent prenatal caffeine exposure adversely affects levels of integrin αVβ3 and MMP-9 in a rat model of embryo implantation.
    Bratislavske lekarske listy, 2020, Volume: 121, Issue:9

    Topics: Animals; Caffeine; Embryo Implantation; Female; Integrin alphaVbeta3; Matrix Metalloproteinase 9; Pr

2020
Caffeine exposure in utero is associated with structural brain alterations and deleterious neurocognitive outcomes in 9-10 year old children.
    Neuropharmacology, 2021, 03-15, Volume: 186

    Topics: Brain; Caffeine; Central Nervous System Stimulants; Child; Developmental Disabilities; Female; Human

2021
Prenatal caffeine exposure caused H-type blood vessel-related long bone dysplasia via miR375/CTGF signaling.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:2

    Topics: Animals; Bone Development; Bone Diseases, Developmental; Caffeine; Cells, Cultured; Chondrocytes; Co

2021
Intrauterine endogenous high glucocorticoids program ovarian dysfunction in female offspring secondary to prenatal caffeine exposure.
    The Science of the total environment, 2021, Oct-01, Volume: 789

    Topics: Animals; Caffeine; Corticosterone; Female; Glucocorticoids; Pregnancy; Prenatal Exposure Delayed Eff

2021
Prenatal caffeine exposure: association with neurodevelopmental outcomes in 9- to 11-year-old children.
    Journal of child psychology and psychiatry, and allied disciplines, 2022, Volume: 63, Issue:5

    Topics: Adolescent; Brain; Caffeine; Child; Child Development; Cognition; Female; Humans; Male; Pregnancy; P

2022
Maternal Smoking during Pregnancy Is Associated with Offspring Hypodontia.
    Journal of dental research, 2017, Volume: 96, Issue:9

    Topics: Adolescent; Adult; Alcohol Drinking; Anodontia; Caffeine; Case-Control Studies; Female; Gestational

2017
Early-life exposure to caffeine affects the construction and activity of cortical networks in mice.
    Experimental neurology, 2017, Volume: 295

    Topics: Animals; Animals, Newborn; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Dendrites;

2017
Prenatal caffeine exposure induced high susceptibility to metabolic syndrome in adult female offspring rats and its underlying mechanisms.
    Reproductive toxicology (Elmsford, N.Y.), 2017, Volume: 71

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Blood Glucose; Caffeine; Central Nervous Syste

2017
Maternal Smoking, Alcohol, and Caffeine Exposures and Risk of Hypospadias.
    Birth defects research, 2017, Aug-15, Volume: 109, Issue:14

    Topics: Adult; Alcohol Drinking; Caffeine; Case-Control Studies; Cigarette Smoking; Ethanol; Female; Humans;

2017
Maternal Caffeine Consumption during Pregnancy and Behavioral Disorders in 11-Year-Old Offspring: A Danish National Birth Cohort Study.
    The Journal of pediatrics, 2017, Volume: 189

    Topics: Adolescent; Adult; Caffeine; Child; Child Behavior Disorders; Cohort Studies; Denmark; Female; Human

2017
Effects of prenatal caffeine exposure on glucose homeostasis of adult offspring rats.
    Die Naturwissenschaften, 2017, Oct-09, Volume: 104, Issue:11-12

    Topics: Animals; Blood Glucose; Caffeine; Diabetes Mellitus, Type 2; Female; Fetal Growth Retardation; Gene

2017
Prenatal caffeine ingestion increases susceptibility to pulmonary inflammation in adult female rat offspring.
    Reproductive toxicology (Elmsford, N.Y.), 2017, Volume: 74

    Topics: Animals; Caffeine; Cytokines; Female; Fetal Growth Retardation; Inflammation; Lung; Pregnancy; Prena

2017
Glucocorticoid mediates prenatal caffeine exposure-induced endochondral ossification retardation and its molecular mechanism in female fetal rats.
    Cell death & disease, 2017, 10-26, Volume: 8, Issue:10

    Topics: Animals; Caffeine; Cell Differentiation; Female; Fetal Growth Retardation; Fetus; Glucocorticoids; O

2017
High-fat diet and chronic stress aggravate adrenal function abnormality induced by prenatal caffeine exposure in male offspring rats.
    Scientific reports, 2017, 11-01, Volume: 7, Issue:1

    Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenal Glands; Animals; Caffeine; Corticosterone; Diet, High

2017
High expression of hippocampal glutamic acid decarboxylase 67 mediates hypersensitivity of the hypothalamic-pituitary-adrenal axis in response to prenatal caffeine exposure in rats.
    Toxicology letters, 2018, Volume: 283

    Topics: Adrenocorticotropic Hormone; Animals; Caffeine; Cells, Cultured; Corticosterone; Female; gamma-Amino

2018
IGF1/MAPK/ERK signaling pathway-mediated programming alterations of adrenal cortex cell proliferation by prenatal caffeine exposure in male offspring rats.
    Toxicology and applied pharmacology, 2018, 02-15, Volume: 341

    Topics: Adrenal Cortex; Animals; Body Weight; Caffeine; Cell Proliferation; Cells, Cultured; Cellular Reprog

2018
Maternal caffeine intake in pregnancy is inversely related to childhood peer problems in Japan: The Kyushu Okinawa Maternal and Child Health Study.
    Nutritional neuroscience, 2019, Volume: 22, Issue:11

    Topics: Adult; Caffeine; Child, Preschool; Drinking Behavior; Female; Humans; Japan; Male; Maternal Nutritio

2019
Maternal caffeine intake during pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study.
    BMJ open, 2018, 04-23, Volume: 8, Issue:3

    Topics: Caffeine; Child; Child Development; Child, Preschool; Cohort Studies; Diet Records; Eating; Female;

2018
Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine-exposed female adult rat offspring.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018, Volume: 32, Issue:10

    Topics: Animals; Caffeine; CCAAT-Enhancer-Binding Protein-alpha; Cholesterol, LDL; Epigenesis, Genetic; Fema

2018
Influencing factors, underlying mechanism and interactions affecting hypercholesterolemia in adult offspring with caffeine exposure during pregnancy.
    Reproductive toxicology (Elmsford, N.Y.), 2018, Volume: 79

    Topics: Animals; Apolipoproteins B; Caffeine; Cholesterol; Female; Gene Expression Regulation; Hydroxymethyl

2018
Prenatal caffeine ingestion induces long-term alterations in scavenger receptor class B type I expression and glucocorticoid synthesis in adult male offspring rat adrenals.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018, Volume: 120

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Caffeine; Cholesterol; Corticosterone; Female;

2018
Prenatal caffeine exprosure increases adult female offspring rat's susceptibility to osteoarthritis via low-functional programming of cartilage IGF-1 with histone acetylation.
    Toxicology letters, 2018, Oct-01, Volume: 295

    Topics: Acetylation; Aggrecans; Animals; Caffeine; Cartilage, Articular; Cells, Cultured; Central Nervous Sy

2018
Prenatal caffeine damaged learning and memory in rat offspring mediated by ARs/PKA/CREB/BDNF pathway.
    Physiological research, 2018, 12-18, Volume: 67, Issue:6

    Topics: Animals; Brain-Derived Neurotrophic Factor; Caffeine; Cyclic AMP Response Element-Binding Protein; C

2018
Intrauterine Programming of Glucocorticoid-Insulin-Like Growth Factor-1 Axis-Mediated Developmental Origin of Osteoporosis Susceptibility in Female Offspring Rats with Prenatal Caffeine Exposure.
    The American journal of pathology, 2018, Volume: 188, Issue:12

    Topics: Animals; Animals, Newborn; Caffeine; Cells, Cultured; Cellular Reprogramming; Central Nervous System

2018
Activation of local bone RAS by maternal excessive glucocorticoid participated in the fetal programing of adult osteopenia induced by prenatal caffeine exposure.
    Toxicology and applied pharmacology, 2019, 01-15, Volume: 363

    Topics: Animals; Bone and Bones; Bone Diseases, Metabolic; Bone Marrow Cells; Caffeine; Cell Differentiation

2019
Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure.
    Toxicology letters, 2019, Mar-01, Volume: 302

    Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenal Gland Diseases; Adrenal Glands; Age Factors; Animals;

2019
Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway.
    Toxicology, 2019, 04-01, Volume: 417

    Topics: Animals; Caffeine; CCAAT-Binding Factor; Dose-Response Relationship, Drug; Female; Non-alcoholic Fat

2019
Inhibition of thymocyte autophagy-associated CD4
    Archives of toxicology, 2019, Volume: 93, Issue:5

    Topics: Animals; Asthma; Autophagy; Caffeine; CD4-Positive T-Lymphocytes; Central Nervous System Stimulants;

2019
Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats.
    Toxicology, 2019, 04-15, Volume: 418

    Topics: Acetylation; Age Factors; Animals; Caffeine; Cell Line; Cholesterol; Cyclic AMP; Cyclic AMP-Dependen

2019
Dose-dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study.
    Paediatric and perinatal epidemiology, 2019, Volume: 33, Issue:3

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Female; Humans

2019
Maternal, but not paternal or grandparental, caffeine intake is associated with childhood obesity and adiposity: The Lifeways Cross-Generation Cohort Study.
    The American journal of clinical nutrition, 2019, 06-01, Volume: 109, Issue:6

    Topics: Adiposity; Adult; Body Mass Index; Caffeine; Child; Child, Preschool; Coffee; Female; Humans; Male;

2019
The GC-IGF1 axis-mediated testicular dysplasia caused by prenatal caffeine exposure.
    The Journal of endocrinology, 2019, 07-01, Volume: 242, Issue:1

    Topics: Animals; Caffeine; Female; Glucocorticoids; Insulin-Like Growth Factor I; Leydig Cells; Male; Pregna

2019
Decreased H3K9ac level of KLF4 mediates podocyte developmental toxicity induced by prenatal caffeine exposure in male offspring rats.
    Toxicology letters, 2019, Oct-10, Volume: 314

    Topics: Acetylation; Animals; Caffeine; Cells, Cultured; Central Nervous System Stimulants; Female; Gene Exp

2019
Prenatal caffeine exposure induces liver developmental dysfunction in offspring rats.
    The Journal of endocrinology, 2019, 07-26, Volume: 242, Issue:3

    Topics: Animals; Caffeine; Corticosterone; Female; Fetal Development; Fetal Growth Retardation; Gene Express

2019
Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring.
    Toxicology letters, 2014, Jan-30, Volume: 224, Issue:3

    Topics: Algorithms; Animals; Blood Glucose; Body Weight; Caffeine; Central Nervous System Stimulants; Fatty

2014
Prenatal caffeine ingestion induces transgenerational neuroendocrine metabolic programming alteration in second generation rats.
    Toxicology and applied pharmacology, 2014, Feb-01, Volume: 274, Issue:3

    Topics: Animals; Blood Glucose; Body Weight; Caffeine; Cholesterol, HDL; Cholesterol, LDL; Corticosterone; D

2014
The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption.
    Acta cirurgica brasileira, 2014, Volume: 29, Issue:1

    Topics: Animals; Body Mass Index; Caffeine; Eating; Estradiol; Female; Follicle Stimulating Hormone; Leptin;

2014
Embryonic caffeine exposure acts via A1 adenosine receptors to alter adult cardiac function and DNA methylation in mice.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Analysis of Variance; Animals; Caffeine; DNA Methylation; DNA Primers; Echocardiography; Female; Hea

2014
Tobacco smoking and its consequences on reproductive health: the impact of a lifestyle choices including cigarette smoke exposure on fertility and birth defects.
    Przeglad lekarski, 2013, Volume: 70, Issue:10

    Topics: Adolescent; Adult; Alcohol Drinking; Caffeine; Causality; Cohort Studies; Comorbidity; Female; Ferti

2013
Prenatal caffeine intake differently affects synaptic proteins during fetal brain development.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2014, Volume: 36

    Topics: Age Factors; Animals; Animals, Newborn; Brain; Brain-Derived Neurotrophic Factor; Caffeine; Central

2014
Maternal caffeine exposure impairs insulin secretion by pancreatic β-cells and increases the risk of type II diabetes mellitus in offspring.
    Cell biology international, 2014, Volume: 38, Issue:10

    Topics: Animals; Apoptosis; Birth Weight; Blood Glucose; Caffeine; Cells, Cultured; Diabetes Mellitus, Type

2014
Anti-inflammatory effect of caffeine is associated with improved lung function after lipopolysaccharide-induced amnionitis.
    Neonatology, 2014, Volume: 106, Issue:3

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Caffeine; Chorioamnionitis; Disease Models, Ani

2014
Maternal caffeine intake during pregnancy and risk of obesity in offspring: a prospective cohort study.
    International journal of obesity (2005), 2015, Volume: 39, Issue:4

    Topics: Adolescent; Adult; Appetite Regulation; Body Mass Index; Caffeine; Central Nervous System Stimulants

2015
Maternal caffeine exposure alters neuromotor development and hippocampus acetylcholinesterase activity in rat offspring.
    Brain research, 2015, Jan-21, Volume: 1595

    Topics: Acetylcholinesterase; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Caf

2015
Potential confounding still clouds the possible association of maternal caffeine intake and low birth weight.
    Evidence-based medicine, 2015, Volume: 20, Issue:1

    Topics: Birth Weight; Caffeine; Female; Humans; Infant, Low Birth Weight; Male; Pregnancy; Prenatal Exposure

2015
Maternal serum paraxanthine during pregnancy and offspring body mass index at ages 4 and 7 years.
    Epidemiology (Cambridge, Mass.), 2015, Volume: 26, Issue:2

    Topics: Adult; Biomarkers; Body Mass Index; Caffeine; Case-Control Studies; Child; Child, Preschool; Female;

2015
Gender-specific increase in susceptibility to metabolic syndrome of offspring rats after prenatal caffeine exposure with post-weaning high-fat diet.
    Toxicology and applied pharmacology, 2015, May-01, Volume: 284, Issue:3

    Topics: Adrenocorticotropic Hormone; Age Factors; Analysis of Variance; Animal Nutritional Physiological Phe

2015
Review: higher caffeine intake during pregnancy increases risk of low birth weight.
    Evidence-based nursing, 2015, Volume: 18, Issue:4

    Topics: Birth Weight; Caffeine; Female; Humans; Infant, Low Birth Weight; Male; Pregnancy; Prenatal Exposure

2015
Low functional programming of renal AT2R mediates the developmental origin of glomerulosclerosis in adult offspring induced by prenatal caffeine exposure.
    Toxicology and applied pharmacology, 2015, Sep-01, Volume: 287, Issue:2

    Topics: Animals; Caffeine; Creatinine; Female; Fetal Growth Retardation; Kidney Diseases; Male; Pregnancy; P

2015
Prenatal Caffeine Exposure and Child IQ at Age 5.5 Years: The EDEN Mother-Child Cohort.
    Biological psychiatry, 2016, 11-01, Volume: 80, Issue:9

    Topics: Adult; Caffeine; Child; Child Development; Child, Preschool; Cohort Studies; Female; Humans; Intelli

2016
Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age.
    American journal of epidemiology, 2015, Dec-15, Volume: 182, Issue:12

    Topics: Adult; Caffeine; Child; Child Behavior; Child, Preschool; Coffee; Cognition; Female; Follow-Up Studi

2015
Prenatal caffeine exposure induces a poor quality of articular cartilage in male adult offspring rats via cholesterol accumulation in cartilage.
    Scientific reports, 2015, Dec-07, Volume: 5

    Topics: Animals; Biological Transport; Caffeine; Cartilage, Articular; Cholesterol; Diet, High-Fat; Female;

2015
Maternal caffeine intake during pregnancy, early growth, and body fat distribution at school age.
    Obesity (Silver Spring, Md.), 2016, Volume: 24, Issue:5

    Topics: Birth Weight; Body Composition; Body Fat Distribution; Body Mass Index; Caffeine; Child; Coffee; Fem

2016
Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine.
    Metabolic brain disease, 2016, Volume: 31, Issue:5

    Topics: Animals; Anxiety; Caffeine; Central Nervous System Stimulants; Female; Hyperalgesia; Lactation; Male

2016
Intake of Caffeinated Soft Drinks before and during Pregnancy, but Not Total Caffeine Intake, Is Associated with Increased Cerebral Palsy Risk in the Norwegian Mother and Child Cohort Study.
    The Journal of nutrition, 2016, Volume: 146, Issue:9

    Topics: Adult; Caffeine; Carbonated Beverages; Cerebral Palsy; Female; Humans; Infant, Low Birth Weight; Inf

2016
Effects of Oral Maternal Administration of Caffeine on Reproductive Functions of Male Offspring of Wistar Rats.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2015, Dec-20, Volume: 30, Issue:1-2

    Topics: Administration, Oral; Animals; Caffeine; Female; Male; Maternal Exposure; Pregnancy; Prenatal Exposu

2015
Caffeine consumption during pregnancy and ADHD at the age of 11 years: a birth cohort study.
    BMJ open, 2016, 12-05, Volume: 6, Issue:12

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Brazil; Caffeine; Central Nervous System Stimu

2016
Caffeine Intake During Pregnancy in Different Intrauterine Environments and its Association with Infant Anthropometric Measurements at 3 and 6 Months of Age.
    Maternal and child health journal, 2017, Volume: 21, Issue:6

    Topics: Adult; Anthropometry; Body Weight; Brazil; Caffeine; Central Nervous System Stimulants; Child Develo

2017
Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar hypoxia in newborn rats and adenosine A2A and GABA A receptor mRNA transcription.
    Neuroscience, 2008, Oct-15, Volume: 156, Issue:3

    Topics: Adaptation, Physiological; Animals; Animals, Newborn; Body Temperature; Caffeine; Cell Count; Female

2008
Semen quality according to prenatal coffee and present caffeine exposure: two decades of follow-up of a pregnancy cohort.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:12

    Topics: Adult; Caffeine; Coffee; Female; Follow-Up Studies; Humans; Inhibins; Male; Maternal-Fetal Exchange;

2008
Coffee consumption during pregnancy and the risk of hyperkinetic disorder and ADHD: a prospective cohort study.
    Acta paediatrica (Oslo, Norway : 1992), 2009, Volume: 98, Issue:1

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Caffeine; Central Nervous System S

2009
Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice.
    Physiology & behavior, 2008, Dec-15, Volume: 95, Issue:5

    Topics: Amphetamine; Analysis of Variance; Animals; Caffeine; Central Nervous System Stimulants; Darkness; E

2008
Embryonic caffeine exposure induces adverse effects in adulthood.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, Volume: 23, Issue:4

    Topics: Animals; Caffeine; Embryo, Mammalian; Female; Growth; Hypoxia; Maternal Exposure; Maternal-Fetal Exc

2009
Perinatal caffeine, acting on maternal adenosine A(1) receptors, causes long-lasting behavioral changes in mouse offspring.
    PloS one, 2008, Volume: 3, Issue:12

    Topics: Algorithms; Animals; Animals, Newborn; Behavior, Animal; Caffeine; Cocaine; Female; Gene Expression

2008
Maternal exposure to tobacco smoke, alcohol and caffeine, and risk of anorectal atresia: National Birth Defects Prevention Study 1997-2003.
    Paediatric and perinatal epidemiology, 2009, Volume: 23, Issue:1

    Topics: Adult; Alcohol Drinking; Anal Canal; Anus, Imperforate; Caffeine; Case-Control Studies; Central Nerv

2009
Maternal consumption of coffee and caffeine-containing beverages and oral clefts: a population-based case-control study in Norway.
    American journal of epidemiology, 2009, May-15, Volume: 169, Issue:10

    Topics: Caffeine; Case-Control Studies; Cleft Lip; Cleft Palate; Coffee; Confidence Intervals; Female; Healt

2009
Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats.
    Behavioural brain research, 2009, Dec-14, Volume: 205, Issue:1

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Female; Learning Disabilities; Male; Maze Lear

2009
Maternal caffeine intake during gestation and lactation down-regulates adenosine A1 receptor in rat brain from mothers and neonates.
    Journal of neuroscience research, 2010, May-01, Volume: 88, Issue:6

    Topics: Animals; Animals, Newborn; Brain; Caffeine; Central Nervous System Stimulants; Female; Lactation; Ma

2010
Intrauterine exposure to caffeine and inattention/overactivity in children.
    Acta paediatrica (Oslo, Norway : 1992), 2010, Volume: 99, Issue:6

    Topics: Adolescent; Adult; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Caffeine; Fe

2010
A study on neonatal factors and eruption time of primary teeth.
    Community dental health, 2010, Volume: 27, Issue:1

    Topics: Birth Weight; Caffeine; Child, Preschool; Female; Gestational Age; Humans; Infant; Infant, Newborn;

2010
Maternal caffeine consumption and infant nighttime waking: prospective cohort study.
    Pediatrics, 2012, Volume: 129, Issue:5

    Topics: Adult; Arousal; Brazil; Breast Feeding; Caffeine; Cohort Studies; Dose-Response Relationship, Drug;

2012
Caffeine intake during pregnancy and risk of problem behavior in 5- to 6-year-old children.
    Pediatrics, 2012, Volume: 130, Issue:2

    Topics: Affective Symptoms; Attention Deficit Disorder with Hyperactivity; Caffeine; Child; Child Behavior D

2012
A hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion.
    Toxicology and applied pharmacology, 2012, Nov-01, Volume: 264, Issue:3

    Topics: Animals; Birth Weight; Blood Glucose; Caffeine; Female; Fetal Growth Retardation; Hippocampus; Hypot

2012
Consumption of coffee during pregnancy: article raises more questions than it answers.
    BMJ (Clinical research ed.), 2003, Jun-07, Volume: 326, Issue:7401

    Topics: Caffeine; Coffee; Female; Fetal Death; Humans; Infant Mortality; Infant, Newborn; Pregnancy; Prenata

2003
Maternal atopic disease modifies effects of prenatal risk factors on exhaled nitric oxide in infants.
    American journal of respiratory and critical care medicine, 2004, Aug-01, Volume: 170, Issue:3

    Topics: Anthropometry; Asthma; Breath Tests; Caffeine; Coffee; Cohort Studies; Environmental Exposure; Fathe

2004
Consequences of smoking and caffeine consumption during pregnancy in women with type 1 diabetes.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2004, Volume: 15, Issue:1

    Topics: Abortion, Spontaneous; Adult; Birth Weight; Caffeine; Diabetes Mellitus, Type 1; Female; Humans; Pre

2004
Involvement of adenosinergic A1 systems in the occurrence of respiratory perturbations encountered in newborns following an in utero caffeine exposure. a study on brainstem-spinal cord preparations isolated from newborn rats.
    Neuroscience, 2004, Volume: 127, Issue:2

    Topics: Adenosine; Animals; Animals, Newborn; Caffeine; Female; In Vitro Techniques; Medulla Oblongata; Neur

2004
Excessive maternal caffeine exposure during pregnancy is cataractogenic for neonatal crystalline lenses in rats: a biomicroscopic and histopathologic study.
    Acta ophthalmologica Scandinavica, 2004, Volume: 82, Issue:5

    Topics: Animals; Animals, Newborn; Caffeine; Cataract; Dose-Response Relationship, Drug; Female; Lens, Cryst

2004
Chronic caffeine or theophylline intake during pregnancy inhibits A1 receptor function in the rat brain.
    Neuroscience, 2005, Volume: 131, Issue:2

    Topics: Adenosine A1 Receptor Antagonists; Adenylyl Cyclases; Animals; Brain; Caffeine; Female; Pregnancy; P

2005
Maternal caffeine intake impairs MK-801-induced hyperlocomotion in young rats.
    European journal of pharmacology, 2005, Feb-21, Volume: 509, Issue:2-3

    Topics: Animals; Animals, Newborn; Caffeine; Central Nervous System Stimulants; Dizocilpine Maleate; Female;

2005
Effect of chronic gestational treatment with caffeine or theophylline on Group I metabotropic glutamate receptors in maternal and fetal brain.
    Journal of neurochemistry, 2005, Volume: 94, Issue:2

    Topics: Animals; Blotting, Western; Brain; Caffeine; Cell Membrane; Dose-Response Relationship, Drug; Drug I

2005
Caffeine in the milk prevents respiratory disorders caused by in utero caffeine exposure in rats.
    Respiratory physiology & neurobiology, 2006, Jan-25, Volume: 150, Issue:1

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Female; Hypoxia; Milk; Pregnancy; Prenatal Exp

2006
Neonatal withdrawal syndrome after chronic maternal drinking of mate.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:1

    Topics: Beverages; Breast Feeding; Caffeine; Female; Humans; Ilex paraguariensis; Infant, Newborn; Neonatal

2007
Intrauterine exposures and risk of endometriosis.
    Human reproduction (Oxford, England), 2007, Volume: 22, Issue:12

    Topics: Adolescent; Adult; Alcohol Drinking; Caffeine; Cimicifuga; Endometriosis; Female; Humans; Laparoscop

2007
Effects of chronic caffeine on brain adenosine receptors: regional and ontogenetic studies.
    Life sciences, 1984, Feb-27, Volume: 34, Issue:9

    Topics: Adenosine; Animals; Brain; Brain Stem; Caffeine; Cerebellum; Female; Male; Mice; Pregnancy; Prenatal

1984
Effects of caffeine on the growth of mandible and long bone in protein-energy malnourished newborn rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1984, Volume: 177, Issue:1

    Topics: Animals; Body Weight; Bone and Bones; Caffeine; Calcium; Collagen; Female; Hydroxyproline; Organ Siz

1984
Long-lasting tolerance to stimulatory effects of perinatal caffeine treatment.
    Psychopharmacology, 1984, Volume: 84, Issue:2

    Topics: Animals; Caffeine; Drug Tolerance; Female; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effe

1984
Behavioral and physical development of rats chronically exposed to caffeinated fluids.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:1

    Topics: Animals; Behavior, Animal; Caffeine; Coffee; Female; Growth; Male; Pregnancy; Prenatal Exposure Dela

1984
Gestational caffeine modifies offspring behaviour in mice.
    Psychopharmacology, 1981, Volume: 75, Issue:1

    Topics: Animals; Avoidance Learning; Behavior, Animal; Caffeine; Dextroamphetamine; Dopamine; Female; Male;

1981
The interaction of chemicals during pregnancy: an update.
    Biological research in pregnancy and perinatology, 1983, Volume: 4, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Bromodeoxyuridine; Caffeine; Drug Interactions; Female; Fetus;

1983
Pre- and postnatal effects of caffeine on brain biogenic amines, cyclic nucleotides and behavior in developing rats.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3

    Topics: Animals; Animals, Newborn; Behavior, Animal; Biogenic Amines; Body Weight; Brain Chemistry; Caffeine

1983
The effects of maternal carbohydrate (sucrose) supplementation on the growth of offspring of pregnancies with habitual caffeine consumption.
    Biology of the neonate, 1981, Volume: 40, Issue:3-4

    Topics: Animals; Animals, Newborn; Blood Glucose; Body Weight; Caffeine; Dietary Carbohydrates; Female; Male

1981
The effect of long term caffeine treatment on hypoxic-ischemic brain damage in the neonate.
    Pediatric research, 1995, Volume: 38, Issue:3

    Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; Caffeine; Central Nervous System Stimulants; Femal

1995
Correlation of prenatal events with the development of polymicrogyria.
    AJNR. American journal of neuroradiology, 1995, Volume: 16, Issue:4 Suppl

    Topics: Abnormalities, Drug-Induced; Brain; Caffeine; Cerebral Cortex; Child; Child, Preschool; Ergotamine;

1995
Caffeine, health and commercial interests.
    Addiction (Abingdon, England), 1995, Volume: 90, Issue:7

    Topics: Caffeine; Female; Humans; Infant, Newborn; Peer Review; Pregnancy; Prenatal Exposure Delayed Effects

1995
Alteration of femoral structure in later life by chronically feeding caffeine during rapid growing period in newborn female rats.
    Toxicology letters, 1994, Volume: 73, Issue:1

    Topics: Animals; Bone and Bones; Bone Density; Bone Development; Caffeine; Female; Femur; Mandible; Pregnanc

1994
Combined effects of caffeine and malnutrition during pregnancy on suckling behavior in newborn rats.
    Physiology & behavior, 1994, Volume: 56, Issue:1

    Topics: Animals; Body Weight; Caffeine; Dose-Response Relationship, Drug; Female; Fetal Movement; Gestationa

1994
Several genetic and environmental factors influence cord blood IgE concentration.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 1994, Volume: 5, Issue:2

    Topics: Alcohol Drinking; Birth Weight; Caffeine; Female; Fetal Blood; Humans; Hypersensitivity, Immediate;

1994
In utero caffeine exposure affects feeding pattern and variable ratio performance in infant monkeys.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1994, Volume: 22, Issue:1

    Topics: Animals; Animals, Newborn; Caffeine; Feeding Behavior; Female; Macaca fascicularis; Pregnancy; Prena

1994
The effect of prenatal caffeine exposure on the enamel surface of the first molars of newborn rats.
    Archives of oral biology, 1993, Volume: 38, Issue:5

    Topics: Animals; Animals, Newborn; Caffeine; Calcium; Dental Enamel; Dental Enamel Solubility; Drug Implants

1993
Newborn cardiac arrhythmias associated with maternal caffeine use during pregnancy.
    Clinical pediatrics, 1993, Volume: 32, Issue:1

    Topics: Arrhythmias, Cardiac; Caffeine; Coffee; Female; Humans; Infant, Newborn; Pregnancy; Prenatal Exposur

1993
Effects of diazepam and cyclohexyladenosine on open-field behavior in rats perinatally exposed to caffeine.
    Life sciences, 1996, Volume: 58, Issue:8

    Topics: Adenosine; Animals; Caffeine; Diazepam; Eliminative Behavior, Animal; Emotions; Female; Grooming; Lo

1996
Combined effects of caffeine and alcohol during pregnancy on bones in newborn rats.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1996, Volume: 196, Issue:3

    Topics: Animals; Animals, Newborn; Caffeine; Calcium; Central Nervous System Depressants; Central Nervous Sy

1996
Autism, Asperger's syndrome and the Crick-Mitchison theory of the biological function of REM sleep.
    Medical hypotheses, 1996, Volume: 47, Issue:5

    Topics: Autistic Disorder; Brain; Caffeine; Female; Fetus; Humans; Infant; Infant, Newborn; Models, Neurolog

1996
Demonstration of congenital anomalies in the joints of the forelimbs and hindlimbs caused by several pharmacological agents.
    Anatomia, histologia, embryologia, 1996, Volume: 25, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agen

1996
Heavy caffeine intake in pregnancy and sudden infant death syndrome. New Zealand Cot Death Study Group.
    Archives of disease in childhood, 1998, Volume: 78, Issue:1

    Topics: Caffeine; Carbonated Beverages; Case-Control Studies; Coffee; Female; Humans; Infant; Pregnancy; Pre

1998
Heavy caffeine consumption in pregnancy, smoking, and sudden infant death syndrome.
    Archives of disease in childhood, 1998, Volume: 79, Issue:3

    Topics: Caffeine; Female; Humans; Infant; Pregnancy; Prenatal Exposure Delayed Effects; Smoking; Sudden Infa

1998
Caffeine and alcohol as risk factors for sudden infant death syndrome. Nordic Epidemiological SIDS Study.
    Archives of disease in childhood, 1999, Volume: 81, Issue:2

    Topics: Alcohol Drinking; Caffeine; Dose-Response Relationship, Drug; Female; Humans; Infant; Infant, Newbor

1999
Maternal caffeine intake has minor effects on adenosine receptor ontogeny in the rat brain.
    Pediatric research, 2000, Volume: 48, Issue:2

    Topics: Adenosine; Animals; Animals, Newborn; Autoradiography; Brain; Caffeine; Female; Gene Expression Regu

2000
Testing for behavioral effects of agents.
    Neurobehavioral toxicology, 1979, Volume: 1 Suppl 1

    Topics: Animals; Atropine; Behavior, Animal; Brain; Caffeine; Conditioning, Operant; Female; Mice; Motor Act

1979
Caffeine-mediated effects on reproductive health over two generations in rats.
    Reproductive toxicology (Elmsford, N.Y.), 1992, Volume: 6, Issue:6

    Topics: Animals; Birth Weight; Caffeine; Cohort Effect; Dose-Response Relationship, Drug; Female; Labor, Obs

1992
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
    European journal of pharmacology, 1991, Apr-24, Volume: 196, Issue:3

    Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Femal

1991
Somatic development of the infant monkey following in utero exposure to caffeine.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1991, Volume: 17, Issue:3

    Topics: Animals; Body Weight; Caffeine; Female; Half-Life; Humans; Infant, Newborn; Macaca fascicularis; Mal

1991
Lasting effects of early chronic caffeine feeding on rats' behavior and brain in later life.
    Physiology & behavior, 1991, Volume: 49, Issue:4

    Topics: Animals; Behavior, Animal; Body Weight; Brain; Caffeine; DNA Replication; Female; Motor Activity; Or

1991
Sex-and age-dependent effects of prenatal exposure to caffeine on open-field behavior, emergence latency and adrenal weights in rats.
    Life sciences, 1990, Volume: 47, Issue:22

    Topics: Adrenal Glands; Aging; Animals; Behavior, Animal; Caffeine; Exploratory Behavior; Female; Male; Moto

1990
Influence of caffeine administered during pregnancy on the early differentiation of fetal rat ovaries and testes.
    Journal of developmental physiology, 1990, Volume: 13, Issue:2

    Topics: 3-Hydroxysteroid Dehydrogenases; Administration, Oral; Animals; Caffeine; Cell Differentiation; Fema

1990
Effects of caffeine intake during gestation and lactation on bones of young growing rats.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1990, Volume: 190, Issue:2

    Topics: Animals; Bone Development; Caffeine; Female; Femur; Hardness; Lactation; Male; Mandible; Organ Size;

1990
Sixth International Caffeine Workshop, Hong Kong, 7-10 August 1989.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1990, Volume: 28, Issue:4

    Topics: Adenosine; Animals; Arrhythmias, Cardiac; Bone Development; Caffeine; DNA Replication; Female; Human

1990
Effects of maternal caffeine with zinc intake during gestation and lactation on bone development in newborn rats.
    Archives of oral biology, 1990, Volume: 35, Issue:6

    Topics: Animals; Bone Development; Caffeine; Diet; Embryonic and Fetal Development; Female; Femur; Lactation

1990
Alteration of the effects of caffeine by prenatal stress.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:1

    Topics: Animals; Body Temperature; Caffeine; Corticosterone; Defecation; Female; Male; Motor Activity; Pregn

1989
Prenatal caffeine causes long lasting behavioral and neurochemical changes.
    The International journal of neuroscience, 1988, Volume: 41, Issue:1-2

    Topics: Animals; Avoidance Learning; Behavior, Animal; Brain; Caffeine; Cerebral Cortex; Choline; Discrimina

1988
Effects of caffeine administered during pregnancy on fetal development and subsequent function in the adult rat: prolonged effects on a second generation.
    Journal of toxicology and environmental health, 1987, Volume: 22, Issue:1

    Topics: 3-Hydroxysteroid Dehydrogenases; Abnormalities, Drug-Induced; Animals; Birth Weight; Caffeine; Embry

1987
Effect of chronic caffeine intake on myocardial function during early growth.
    Pediatric research, 1987, Volume: 21, Issue:4

    Topics: Adipose Tissue; Animals; Caffeine; Coronary Circulation; Female; Heart; Hemodynamics; Lactation; Org

1987
Effects of maternal smoking and caffeine habits on infantile apnea: a retrospective study.
    Pediatrics, 1986, Volume: 78, Issue:1

    Topics: Apnea; Birth Weight; Caffeine; Female; Humans; Infant, Newborn; Maternal Age; Pregnancy; Prenatal Ex

1986
Behavioral effects of prenatal exposure to caffeine in rats.
    Life sciences, 1986, Mar-10, Volume: 38, Issue:10

    Topics: Aging; Animals; Behavior, Animal; Caffeine; Emotions; Female; Male; Motor Activity; Pregnancy; Prena

1986