Page last updated: 2024-10-24

caffeine and Cognitive Dysfunction

caffeine has been researched along with Cognitive Dysfunction in 25 studies

Cognitive Dysfunction: Diminished or impaired mental and/or intellectual function.

Research Excerpts

ExcerptRelevanceReference
"The CAffeine, Postoperative Delirium And CHange In Outcomes after Surgery-2 (CAPACHINOS-2) Trial is a single-centre, placebo-controlled, randomised clinical trial that will be conducted at Michigan Medicine."9.69Caffeine, Postoperative Delirium And Change In Outcomes after Surgery (CAPACHINOS)-2: protocol for a randomised controlled trial. ( Inouye, SK; Jewell, E; Lee, U; Martinez, S; Mashour, GA; McKinney, A; Mentz, G; Ragheb, J; Runstadler, N; Schmitt, EM; Vanini, G; Vlisides, PE, 2023)
"Epidemiologic studies have provided inconclusive evidence for a protective effect of caffeine consumption on risk of dementia and cognitive decline."9.05Associations Between Caffeine Consumption, Cognitive Decline, and Dementia: A Systematic Review. ( Chen, JQA; Groot, C; Ossenkoppele, R; Scheltens, P, 2020)
"Ryanodine receptor agonist caffeine may improve cognitive dysfunction in mice after isoflurane anesthesia."8.31Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction. ( Gu, X; Liu, B; Ma, Z; Qian, Y; Su, Y; Xia, T; Zhou, Q; Zhu, X, 2023)
"Recent evidence indicates that caffeine may have a beneficial effect on cognitive decline and dementia."7.85Caffeine impact on working memory-related network activation patterns in early stages of cognitive decline. ( Giannakopoulos, P; Haller, S; Hofmeister, J; Montandon, ML; Moser, D; Rodriguez, C; Toma, S, 2017)
" In particular, several cross-sectional and longitudinal population-based studies suggested a protective effect of coffee, tea, and caffeine use against late-life cognitive impairment/decline, although the association was not found in all cognitive domains investigated and there was a lack of a distinct dose-response association, with a stronger effect among women than men."6.52Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review. ( Barulli, MR; Bonfiglio, C; Guerra, V; Logroscino, G; Osella, A; Panza, F; Pilotto, A; Sabbà, C; Seripa, D; Solfrizzi, V, 2015)
"Caffeine is a psychoactive compound used widely to enhance cognitive functions in human or animal studies."5.72Effect of intranasal administration of caffeine on mPFC ischemia‑induced cognitive impairment in BALB/c mice. ( Farajdokht, F; Farhoudi, M; Farokhi-Sisakht, F; Kahfi-Ghaneh, R; Mahmoudi, J; Sadigh-Eteghad, S, 2022)
"The CAffeine, Postoperative Delirium And CHange In Outcomes after Surgery-2 (CAPACHINOS-2) Trial is a single-centre, placebo-controlled, randomised clinical trial that will be conducted at Michigan Medicine."5.69Caffeine, Postoperative Delirium And Change In Outcomes after Surgery (CAPACHINOS)-2: protocol for a randomised controlled trial. ( Inouye, SK; Jewell, E; Lee, U; Martinez, S; Mashour, GA; McKinney, A; Mentz, G; Ragheb, J; Runstadler, N; Schmitt, EM; Vanini, G; Vlisides, PE, 2023)
"Epidemiologic studies have provided inconclusive evidence for a protective effect of caffeine consumption on risk of dementia and cognitive decline."5.05Associations Between Caffeine Consumption, Cognitive Decline, and Dementia: A Systematic Review. ( Chen, JQA; Groot, C; Ossenkoppele, R; Scheltens, P, 2020)
"Ryanodine receptor agonist caffeine may improve cognitive dysfunction in mice after isoflurane anesthesia."4.31Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction. ( Gu, X; Liu, B; Ma, Z; Qian, Y; Su, Y; Xia, T; Zhou, Q; Zhu, X, 2023)
"Recent evidence indicates that caffeine may have a beneficial effect on cognitive decline and dementia."3.85Caffeine impact on working memory-related network activation patterns in early stages of cognitive decline. ( Giannakopoulos, P; Haller, S; Hofmeister, J; Montandon, ML; Moser, D; Rodriguez, C; Toma, S, 2017)
"Beneficial effects of caffeine on memory processes have been observed in animal models relevant to neurodegenerative diseases and aging, although the underlying mechanisms remain unknown."3.79Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. ( Ardais, AP; Botton, PH; Costa, MS; Elisabetsky, E; Fioreze, GT; Forte, T; Klaudat, B; Nunes, F; Porciúncula, LO; Sallaberry, C; Souza, DO, 2013)
" In particular, several cross-sectional and longitudinal population-based studies suggested a protective effect of coffee, tea, and caffeine use against late-life cognitive impairment/decline, although the association was not found in all cognitive domains investigated and there was a lack of a distinct dose-response association, with a stronger effect among women than men."2.52Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review. ( Barulli, MR; Bonfiglio, C; Guerra, V; Logroscino, G; Osella, A; Panza, F; Pilotto, A; Sabbà, C; Seripa, D; Solfrizzi, V, 2015)
" The RCS results suggested an approximately linear dose-response relationship between the aforementioned metabolites and cognitive performance."1.91Associations between urinary caffeine and caffeine metabolites and cognitive function in older adults. ( Cai, J; Cen, M; Chen, X; Fu, X; Li, H; Song, L; Wu, J; Yao, T, 2023)
"Caffeine intake was not associated with cognitive decline."1.72Caffeine Consumption and Dementia: Are Lewy Bodies the Link? ( Bennett, DA; Cornelis, MC; Morris, MC; Schneider, JA; Weintraub, S, 2022)
"Caffeine is a psychoactive compound used widely to enhance cognitive functions in human or animal studies."1.72Effect of intranasal administration of caffeine on mPFC ischemia‑induced cognitive impairment in BALB/c mice. ( Farajdokht, F; Farhoudi, M; Farokhi-Sisakht, F; Kahfi-Ghaneh, R; Mahmoudi, J; Sadigh-Eteghad, S, 2022)
"Methylphenidate (MPH) is a psychostimulant widely misused to increase wakefulness by drivers and students."1.62Stimulants cocktail: Methylphenidate plus caffeine impairs memory and cognition and alters mitochondrial and oxidative status. ( Barcellos, LJG; de Alcantara Barcellos, HH; Fortuna, M; Freddo, N; Koakoski, G; Maffi, VC; Mozzato, MT; Pompermaier, A; Rossato-Grando, LG; Soares, SM; Varela, ACC, 2021)
"Caffeine is a common stimulant widely existed in food and has stimulatory effects on the central nervous system, shift-work individuals often rely on caffeine to maintain attention and keep awake."1.62Caffeine-related effects on cognitive performance: Roles of apoptosis in rat hippocampus following sleep deprivation. ( Huang, P; Huang, X; Li, H; Wang, P; Xie, G, 2021)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's13 (52.00)24.3611
2020's12 (48.00)2.80

Authors

AuthorsStudies
Xu, YX1
Wang, H1
Li, XK1
Dong, SN1
Liu, WW1
Gong, Q1
Wang, TD1
Tang, Y1
Zhu, J1
Li, J1
Zhang, HY1
Mao, F1
Cornelis, MC1
Bennett, DA1
Weintraub, S1
Schneider, JA1
Morris, MC1
Fu, X1
Li, H2
Chen, X1
Cai, J2
Yao, T1
Song, L1
Cen, M1
Wu, J1
Farokhi-Sisakht, F1
Farhoudi, M1
Mahmoudi, J1
Farajdokht, F1
Kahfi-Ghaneh, R1
Sadigh-Eteghad, S1
Vlisides, PE1
Ragheb, J1
McKinney, A1
Mentz, G1
Runstadler, N1
Martinez, S1
Jewell, E1
Lee, U1
Vanini, G1
Schmitt, EM1
Inouye, SK1
Mashour, GA1
Merighi, S1
Travagli, A1
Nigro, M1
Pasquini, S1
Cappello, M1
Contri, C1
Varani, K1
Vincenzi, F1
Borea, PA1
Gessi, S1
Liu, B1
Zhu, X1
Zhou, Q1
Su, Y1
Qian, Y1
Ma, Z1
Gu, X1
Xia, T1
Iranpour, S1
Saadati, HM1
Koohi, F1
Sabour, S1
Freddo, N1
Soares, SM1
Fortuna, M1
Pompermaier, A1
Varela, ACC1
Maffi, VC1
Mozzato, MT1
de Alcantara Barcellos, HH1
Koakoski, G1
Barcellos, LJG1
Rossato-Grando, LG1
Chen, JQA1
Scheltens, P1
Groot, C1
Ossenkoppele, R1
Xie, G1
Huang, X1
Wang, P1
Huang, P1
Alhowail, A1
Aldubayan, M1
Londzin, P1
Zamora, M1
Kąkol, B1
Taborek, A1
Folwarczna, J1
Lalanne, L1
Lutz, PE1
Paille, F1
Hussain, A1
Tabrez, ES1
Mavrych, V1
Bolgova, O1
Peela, JR1
Dominguez, LJ1
Barbagallo, M1
Haller, S3
Montandon, ML3
Rodriguez, C3
Herrmann, FR1
Giannakopoulos, P3
Cassol, G1
Godinho, DB1
de Zorzi, VN1
Farinha, JB1
Della-Pace, ID1
de Carvalho Gonçalves, M1
Oliveira, MS1
Furian, AF1
Fighera, MR1
Royes, LFF1
Moser, D2
Toma, S2
Hofmeister, J2
Sinanaj, I1
Lovblad, KO1
Panza, F2
Solfrizzi, V2
Barulli, MR1
Bonfiglio, C1
Guerra, V2
Osella, A2
Seripa, D2
Sabbà, C2
Pilotto, A2
Logroscino, G2
Imbimbo, BP1
D'Introno, A1
Galluzzo, L1
Gandin, C1
Misciagna, G1
Baldereschi, M1
Di Carlo, A1
Inzitari, D1
Scafato, E1
Batalha, VL1
Ferreira, DG1
Coelho, JE1
Valadas, JS1
Gomes, R1
Temido-Ferreira, M1
Shmidt, T1
Baqi, Y1
Buée, L1
Müller, CE1
Hamdane, M1
Outeiro, TF1
Bader, M1
Meijsing, SH1
Sadri-Vakili, G1
Blum, D1
Lopes, LV1
Cao, C1
Loewenstein, DA1
Lin, X1
Zhang, C1
Wang, L1
Duara, R1
Wu, Y1
Giannini, A1
Bai, G1
Greig, M1
Schofield, E1
Ashok, R1
Small, B1
Potter, H1
Arendash, GW1
Sallaberry, C1
Nunes, F1
Costa, MS1
Fioreze, GT1
Ardais, AP1
Botton, PH1
Klaudat, B1
Forte, T1
Souza, DO1
Elisabetsky, E1
Porciúncula, LO1

Reviews

9 reviews available for caffeine and Cognitive Dysfunction

ArticleYear
Caffeine for Prevention of Alzheimer's Disease: Is the A
    Biomolecules, 2023, 06-08, Volume: 13, Issue:6

    Topics: Alzheimer Disease; Caffeine; Coffee; Cognitive Dysfunction; Humans; Neuroprotective Agents; Receptor

2023
Associations Between Caffeine Consumption, Cognitive Decline, and Dementia: A Systematic Review.
    Journal of Alzheimer's disease : JAD, 2020, Volume: 78, Issue:4

    Topics: Caffeine; Coffee; Cognitive Dysfunction; Dementia; Humans; Protective Factors; Sex Factors; Tea

2020
Mechanisms underlying cognitive impairment induced by prenatal caffeine exposure.
    European review for medical and pharmacological sciences, 2020, Volume: 24, Issue:22

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Cognitive Dysfunction; Female; Fetal Developme

2020
Potential of Caffeine in Alzheimer's Disease-A Review of Experimental Studies.
    Nutrients, 2021, Feb-06, Volume: 13, Issue:2

    Topics: Alzheimer Disease; Animals; Caffeine; Cognition; Cognitive Dysfunction; Humans

2021
Acute impact of caffeinated alcoholic beverages on cognition: A systematic review.
    Progress in neuro-psychopharmacology & biological psychiatry, 2017, 06-02, Volume: 76

    Topics: Alcoholic Beverages; Alcoholic Intoxication; Caffeine; Cognitive Dysfunction; Energy Drinks; Humans

2017
Caffeine: A Potential Protective Agent Against Cognitive Decline in Alzheimer's Disease.
    Critical reviews in eukaryotic gene expression, 2018, Volume: 28, Issue:1

    Topics: Alzheimer Disease; Caffeine; Central Nervous System Stimulants; Cognitive Dysfunction; Humans; Prote

2018
Nutritional prevention of cognitive decline and dementia.
    Acta bio-medica : Atenei Parmensis, 2018, 06-07, Volume: 89, Issue:2

    Topics: Antioxidants; Autophagy; Caffeine; Catechin; Central Nervous System Stimulants; Chocolate; Cognitive

2018
Potential therapeutic implications of ergogenic compounds on pathophysiology induced by traumatic brain injury: A narrative review.
    Life sciences, 2019, Sep-15, Volume: 233

    Topics: Animals; Arginine; Brain Injuries, Traumatic; Caffeine; Carnitine; Central Nervous System Stimulants

2019
Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review.
    The journal of nutrition, health & aging, 2015, Volume: 19, Issue:3

    Topics: Alzheimer Disease; Caffeine; Coffee; Cognition; Cognition Disorders; Cognitive Dysfunction; Dementia

2015

Trials

2 trials available for caffeine and Cognitive Dysfunction

ArticleYear
Caffeine, Postoperative Delirium And Change In Outcomes after Surgery (CAPACHINOS)-2: protocol for a randomised controlled trial.
    BMJ open, 2023, 05-15, Volume: 13, Issue:5

    Topics: Aged; Caffeine; Cognitive Dysfunction; Delirium; Emergence Delirium; Humans; Michigan; Randomized Co

2023
Acute caffeine administration effect on brain activation patterns in mild cognitive impairment.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 41, Issue:1

    Topics: Aged; Brain; Brain Mapping; Caffeine; Central Nervous System Stimulants; Cerebrovascular Circulation

2014

Other Studies

14 other studies available for caffeine and Cognitive Dysfunction

ArticleYear
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors;

2018
Caffeine Consumption and Dementia: Are Lewy Bodies the Link?
    Annals of neurology, 2022, Volume: 91, Issue:6

    Topics: Alzheimer Disease; Caffeine; Cognitive Dysfunction; Humans; Lewy Bodies; Neuropsychological Tests

2022
Associations between urinary caffeine and caffeine metabolites and cognitive function in older adults.
    Nutritional neuroscience, 2023, Volume: 26, Issue:7

    Topics: Aged; Caffeine; Cognition; Cognitive Dysfunction; Cross-Sectional Studies; Humans; Male; Middle Aged

2023
Effect of intranasal administration of caffeine on mPFC ischemia‑induced cognitive impairment in BALB/c mice.
    Acta neurobiologiae experimentalis, 2022, Volume: 82, Issue:3

    Topics: Administration, Intranasal; Animals; Caffeine; Cognitive Dysfunction; Interleukin-10; Interleukin-6;

2022
Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction.
    Brain research bulletin, 2023, Volume: 204

    Topics: Anesthetics, Inhalation; Animals; Caffeine; Cognitive Dysfunction; Hippocampus; Isoflurane; Male; Mi

2023
Association between caffeine intake and cognitive function in adults; effect modification by sex: Data from National Health and Nutrition Examination Survey (NHANES) 2013-2014.
    Clinical nutrition (Edinburgh, Scotland), 2020, Volume: 39, Issue:7

    Topics: Age Factors; Aged; Aged, 80 and over; Caffeine; Central Nervous System Stimulants; Cognition; Cognit

2020
Stimulants cocktail: Methylphenidate plus caffeine impairs memory and cognition and alters mitochondrial and oxidative status.
    Progress in neuro-psychopharmacology & biological psychiatry, 2021, 03-02, Volume: 106

    Topics: Animals; Caffeine; Central Nervous System Stimulants; Cognition; Cognitive Dysfunction; Female; Male

2021
Caffeine-related effects on cognitive performance: Roles of apoptosis in rat hippocampus following sleep deprivation.
    Biochemical and biophysical research communications, 2021, 01-01, Volume: 534

    Topics: Animals; Apoptosis; Arginine Vasopressin; Caffeine; Central Nervous System Stimulants; Cognition; Co

2021
Impact of Coffee, Wine, and Chocolate Consumption on Cognitive Outcome and MRI Parameters in Old Age.
    Nutrients, 2018, Oct-01, Volume: 10, Issue:10

    Topics: Aged; Aged, 80 and over; Brain; Caffeine; Cerebrovascular Circulation; Chocolate; Coffee; Cognition;

2018
Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging.
    Journal of Alzheimer's disease : JAD, 2015, Volume: 47, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Caffeine; Coffee; Cognitive Dysfunction; Depression; Feeding Behavio

2015
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
    Scientific reports, 2016, 08-11, Volume: 6

    Topics: Aging; Animals; Caffeine; Cell Nucleus; Cognitive Dysfunction; Corticosterone; Humans; Hypothalamo-H

2016
Caffeine impact on working memory-related network activation patterns in early stages of cognitive decline.
    Neuroradiology, 2017, Volume: 59, Issue:4

    Topics: Aged; Caffeine; Case-Control Studies; Cognitive Dysfunction; Cross-Over Studies; Double-Blind Method

2017
High Blood caffeine levels in MCI linked to lack of progression to dementia.
    Journal of Alzheimer's disease : JAD, 2012, Volume: 30, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Caffeine; Case-Control Studies; Cognition; Cognitive Dys

2012
Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats.
    Neuropharmacology, 2013, Volume: 64

    Topics: Aging; Animals; Avoidance Learning; Behavior, Animal; Brain-Derived Neurotrophic Factor; Caffeine; C

2013