caffeine has been researched along with Chromosomal Fragility in 27 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex- and age-matched normal controls." | 3.70 | Common fragile site expression and genetic predisposition to breast cancer. ( Ceçener, G; Duman, H; Egeli, U; Kizil, A; Taşdelen, I; Tunca, B, 1998) |
| "Frequency and distribution of 5-fluorodeoxyuridine (5-FdU) plus caffeine-induced fragile sites on chromosomes of peripheral blood lymphocytes (PBL) from 10 patients with cutaneous melanoma were studied in comparison with 10 PBL samples from normal donors of corresponding sex and age." | 3.68 | Enhanced expression of 1p32 and 1p22 fragile sites in lymphocytes in cutaneous malignant melanomas. ( Chebotarev, AN; Demidov, LV; Kirichenko, OP; Kopnin, BP; Mukeria, AF; Sokova, OI, 1992) |
| "Caffeine has been found by different authors to considerably enhance the expression of chromosome breaks which have been produced by other agents." | 1.28 | The effect of caffeine on DAPI-inducible fragile sites. ( Pelliccia, F; Rocchi, A, 1992) |
| "Our findings suggest that chromosomal abnormalities in childhood malignancies cannot generally be explained by the presence of FdU- or FdU plus caffeine-induced fragile sites." | 1.28 | Relationship between chemical-induced fragile sites and chromosomal breakpoints in malignant cells in children. ( Crist, WM; Douglass, EC; Lewis, S; Raimondi, SC; Ribeiro, RC; Valentine, M; Williams, DL, 1992) |
| "Caffeine did not enhance the expression of the fra(X) in the PBLC or in the three LCL from fra(X) expressing individuals nor did it elicit fra(X) expression in LCL from a non-expressing obligate-carrier female and a transmitting male." | 1.27 | The effect of caffeine on fragile X expression. ( Abruzzo, MA; Jacobs, PA; Mayer, M; Pettay, D, 1986) |
| "Hydroxyurea (HU) is an inhibitor of DNA synthesis, which can inhibit the enzyme ribonucleotide reductase, reduce the syntheses of all four deoxyribonucleoside diphosphates (dNDP), and disturb the balance of the dNTP pool." | 1.27 | The effect of hydroxyurea on the expression of the common fragile site at 3p14. ( Li, XZ; Yan, ZA; Zhou, XT, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (51.85) | 18.7374 |
| 1990's | 10 (37.04) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Casper, AM | 1 |
| Nghiem, P | 1 |
| Arlt, MF | 1 |
| Glover, TW | 2 |
| Yunis, JJ | 2 |
| Soreng, AL | 2 |
| Stone, DM | 1 |
| Stephens, KE | 1 |
| Doles, J | 1 |
| Wenger, SL | 2 |
| Rafi, SK | 1 |
| Surana, RB | 1 |
| Anderson, LH | 1 |
| Wilson, B | 1 |
| Christopher, KL | 1 |
| Mehm, WJ | 1 |
| Kubo, K | 1 |
| Shiomi, A | 1 |
| Asaeda, A | 1 |
| Ohashi, F | 1 |
| Matsuyama, S | 1 |
| Ide, H | 1 |
| Takamori, Y | 1 |
| Ceçener, G | 1 |
| Egeli, U | 3 |
| Taşdelen, I | 1 |
| Tunca, B | 3 |
| Duman, H | 1 |
| Kizil, A | 3 |
| Güven, GS | 1 |
| Hacihanefioğlu, S | 1 |
| Cenani, A | 1 |
| Zorluoğlu, A | 2 |
| Yilmazlar, T | 2 |
| Yerci, O | 2 |
| Pelliccia, F | 1 |
| Rocchi, A | 1 |
| Fundia, AF | 1 |
| Gorla, NB | 1 |
| Bonduel, MM | 1 |
| Azpilicueta, O | 1 |
| Lejarraga, H | 1 |
| Muriel, FS | 1 |
| Larripa, IB | 1 |
| Ribeiro, RC | 1 |
| Douglass, EC | 1 |
| Williams, DL | 1 |
| Raimondi, SC | 1 |
| Valentine, M | 1 |
| Lewis, S | 1 |
| Crist, WM | 1 |
| Sokova, OI | 1 |
| Kirichenko, OP | 1 |
| Mukeria, AF | 1 |
| Demidov, LV | 1 |
| Chebotarev, AN | 1 |
| Kopnin, BP | 1 |
| Smeets, D | 1 |
| Verhagen, A | 1 |
| Hustinx, T | 1 |
| Jordan, DK | 1 |
| Divelbiss, JE | 1 |
| Waziri, MH | 1 |
| Burns, TL | 1 |
| Patil, SR | 1 |
| Abruzzo, MA | 1 |
| Pettay, D | 1 |
| Mayer, M | 1 |
| Jacobs, PA | 1 |
| Rao, PN | 2 |
| Heerema, NA | 2 |
| Palmer, CG | 2 |
| Zollino, M | 1 |
| Neri, G | 1 |
| Robinson, TJ | 1 |
| Elder, FF | 1 |
| Przylepa, KA | 1 |
| De Braekeleer, M | 1 |
| Bowe, AE | 1 |
| Nussbaum, RL | 1 |
| Ledbetter, DH | 1 |
| Yan, ZA | 1 |
| Li, XZ | 1 |
| Zhou, XT | 1 |
| Coyle-Morris, J | 1 |
| Morgan, R | 1 |
1 review available for caffeine and Chromosomal Fragility
| Article | Year |
|---|---|
Fragile X syndrome: a unique mutation in man.
Topics: Caffeine; Chromosome Fragility; Female; Fragile X Syndrome; Genetic Counseling; Genetic Linkage; Gen | 1986 |
1 trial available for caffeine and Chromosomal Fragility
| Article | Year |
|---|---|
Fragile sites induced by FUdR, caffeine, and aphidicolin. Their frequency, distribution, and analysis.
Topics: Adult; Aphidicolin; Caffeine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Diter | 1988 |
25 other studies available for caffeine and Chromosomal Fragility
| Article | Year |
|---|---|
ATR regulates fragile site stability.
Topics: 2-Aminopurine; Antimetabolites; Aphidicolin; Ataxia Telangiectasia Mutated Proteins; Blotting, Weste | 2002 |
Constitutive fragile sites and cancer.
Topics: Adolescent; Adult; Animals; Caffeine; Cells, Cultured; Child; Chromosome Fragile Sites; Chromosome F | 1984 |
Folate-sensitive and aphidicolin-inducible fragile sites are expressed in the genome of the domestic cat.
Topics: Animals; Aphidicolin; Caffeine; Cats; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragi | 1993 |
Chemical induction of sister chromatid exchange at fragile sites.
Topics: Aphidicolin; Caffeine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Floxuridine; | 1995 |
Effects of hyperoxia and caffeine on the expression of fragile site at Xq27.3.
Topics: Caffeine; Cell Line; Chromosome Fragile Sites; Chromosome Fragility; Culture Media; Floxuridine; Gen | 1996 |
Induction of fragile sites by fluorodeoxyuridine and caffeine accompanies with misincorpolation of endogenous uridine nucleotide into DNA of feline fibroblasts.
Topics: Animals; Caffeine; Cats; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; DNA; DNA G | 1998 |
Common fragile site expression and genetic predisposition to breast cancer.
Topics: Aphidicolin; Breast Neoplasms; Caffeine; Chromosome Aberrations; Chromosome Fragile Sites; Chromosom | 1998 |
Expression of aphidicolin, FUdR and caffeine-induced fragile sites in lymphocytes of healthy Turkish individuals.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aphidicolin; Caffeine; Cells, Cultured; Chi | 1999 |
The expression of fragile sites in lymphocytes of patients with rectum cancer and their first-degree relatives.
Topics: Adult; Aged; Aphidicolin; Bromodeoxyuridine; Caffeine; Case-Control Studies; Cells, Cultured; Chromo | 2000 |
The expression frequency of common fragile sites and genetic predisposition to colon cancer.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Alu Elements; Aphidicolin; Bromodeoxyuridine; Caffeine; Chi | 2000 |
The effect of caffeine on DAPI-inducible fragile sites.
Topics: Caffeine; Cells, Cultured; Chi-Square Distribution; Chromosome Fragile Sites; Chromosome Fragility; | 1992 |
Increased expression of 5q31 fragile site in a Bloom syndrome family.
Topics: Bloom Syndrome; Caffeine; Child; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragil | 1992 |
Relationship between chemical-induced fragile sites and chromosomal breakpoints in malignant cells in children.
Topics: Adolescent; Adult; Caffeine; Child; Child, Preschool; Chromosome Aberrations; Chromosome Fragile Sit | 1992 |
Enhanced expression of 1p32 and 1p22 fragile sites in lymphocytes in cutaneous malignant melanomas.
Topics: Adult; Caffeine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human | 1992 |
Familial and individual variation in chromosome fragility.
Topics: Aphidicolin; Caffeine; Cells, Cultured; Child; Chromosome Fragile Sites; Chromosome Fragility; Diter | 1989 |
Fragile site expression in families with von Hippel-Lindau disease.
Topics: Adult; Angiomatosis; Caffeine; Cells, Cultured; Child; Chromosome Fragile Sites; Chromosome Fragilit | 1989 |
The effect of caffeine on fragile X expression.
Topics: Caffeine; Cells, Cultured; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; F | 1986 |
Protective effect of S-adenosylmethionine against the induction of chromosome fragile sites.
Topics: Caffeine; Chromosome Fragile Sites; Chromosome Fragility; DNA Damage; Floxuridine; Humans; Lymphocyt | 1987 |
Multiple common fragile sites are expressed in the genome of the laboratory rat.
Topics: Animals; Aphidicolin; Caffeine; Chromosome Fragile Sites; Chromosome Fragility; Diterpenes; Female; | 1987 |
Chromosome breaks and fragile sites in leukemic bone marrow cells.
Topics: Adolescent; Aged; Bone Marrow; Caffeine; Cells, Cultured; Child; Child, Preschool; Chromosome Aberra | 1988 |
Expression of fragile sites in childhood acute lymphoblastic leukemia patients and normal controls.
Topics: Aphidicolin; Bone Marrow; Caffeine; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Mappi | 1988 |
Breakpoint distribution in variant Philadelphia translocations in chronic myeloid leukemia.
Topics: Aphidicolin; Caffeine; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Diterpene | 1986 |
Fragile sites are targets of diverse mutagens and carcinogens.
Topics: Caffeine; Carcinogens; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; Chrom | 1987 |
The effect of hydroxyurea on the expression of the common fragile site at 3p14.
Topics: Caffeine; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human | 1987 |
Fragile sites: overview, occurrence in acute nonlymphocytic leukemia and effects of caffeine on expression.
Topics: Acute Disease; Caffeine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Chromosome | 1986 |