Page last updated: 2024-10-24

caffeine and Cardiovascular Stroke

caffeine has been researched along with Cardiovascular Stroke in 93 studies

Research Excerpts

ExcerptRelevanceReference
"The effect of high dose caffeine on ventricular arrhythmias was examined in 35 patients with recent myocardial infarctions."9.06High dose caffeine and ventricular arrhythmias. ( Harris, L; Myers, MG, 1990)
"Caffeine (300 mg) was administered to each of 70 patients a mean (+/- standard error of the mean) of 7 +/- 1 days after the onset of acute myocardial infarction to determine its effects on ventricular arrhythmias."9.06Caffeine as a possible cause of ventricular arrhythmias during the healing phase of acute myocardial infarction. ( Grant, DM; Harris, L; Leenen, FH; Myers, MG, 1987)
"Because of possible side effects of herbal medicines containing ephedrine and guarana-derived caffeine, including increased risk of stroke, myocardial infarction, and sudden death, the Food and Drug Administration recently banned the sale of ephedra-containing products, specifically over-the-counter dietary supplements."7.73Acute hemorrhagic myocardial necrosis and sudden death of rats exposed to a combination of ephedrine and caffeine. ( Collins, BJ; Dunnick, JK; Foley, JF; Hanlon, P; Howden, R; Murphy, E; Nyska, A; Petranka, J, 2005)
"Using microelectrode techniques, we investigated the electrophysiologic effects of cocaine on endocardial canine Purkinje fibers that survived 1 day of myocardial infarction."7.69Electrophysiologic effects of cocaine on subendocardial Purkinje fibers surviving 1 day of myocardial infarction. ( Assadi, M; Boutjdir, M; el-Sherif, N, 1995)
"The effect of high dose caffeine on ventricular arrhythmias was examined in 35 patients with recent myocardial infarctions."5.06High dose caffeine and ventricular arrhythmias. ( Harris, L; Myers, MG, 1990)
"Caffeine (300 mg) was administered to each of 70 patients a mean (+/- standard error of the mean) of 7 +/- 1 days after the onset of acute myocardial infarction to determine its effects on ventricular arrhythmias."5.06Caffeine as a possible cause of ventricular arrhythmias during the healing phase of acute myocardial infarction. ( Grant, DM; Harris, L; Leenen, FH; Myers, MG, 1987)
"Physical exertion and caffeine consumption are associated with acute myocardial infarction (MI)."3.91Immediate risk of myocardial infarction following physical exertion, tea, and coffee: A case-crossover study in Thailand. ( Berhane, HY; Chahal, HS; Gelaye, B; Lohsoonthorn, V; Mostofsky, E; Rattananupong, T; Thomas, C; Wuttithai, N; Wynne, K, 2019)
"Myocardial perfusion scintigraphy (MPS) was used to assess adenosine-induced hyperemia in 30 patients before (baseline) and after coffee ingestion (caffeine)."3.74High-dose adenosine overcomes the attenuation of myocardial perfusion reserve caused by caffeine. ( Anagnostopoulos, C; Donovan, J; Harbinson, M; Loong, CY; Reyes, E; Underwood, SR, 2008)
"Because of possible side effects of herbal medicines containing ephedrine and guarana-derived caffeine, including increased risk of stroke, myocardial infarction, and sudden death, the Food and Drug Administration recently banned the sale of ephedra-containing products, specifically over-the-counter dietary supplements."3.73Acute hemorrhagic myocardial necrosis and sudden death of rats exposed to a combination of ephedrine and caffeine. ( Collins, BJ; Dunnick, JK; Foley, JF; Hanlon, P; Howden, R; Murphy, E; Nyska, A; Petranka, J, 2005)
"Using microelectrode techniques, we investigated the electrophysiologic effects of cocaine on endocardial canine Purkinje fibers that survived 1 day of myocardial infarction."3.69Electrophysiologic effects of cocaine on subendocardial Purkinje fibers surviving 1 day of myocardial infarction. ( Assadi, M; Boutjdir, M; el-Sherif, N, 1995)
"These findings do not support the hypothesis that coffee or caffeine consumption increases the risk of coronary heart disease or stroke."3.68Coffee, caffeine, and cardiovascular disease in men. ( Colditz, G; Giovannucci, E; Grobbee, DE; Rimm, EB; Stampfer, M; Willett, W, 1990)
"In the course of evaluating the acute effect of caffeine-containing coffee on the risk of myocardial infarction (MI) among women 30-49 years of age, this study noted appreciable differences in coffee consumption among hospital patients admitted for illnesses not known to be related to coffee use."3.66Case-control studies on the acute effects of coffee upon the risk of myocardial infarction: problems in the selection of a hospital control series. ( Kaufman, DW; Miettinen, OS; Rosenberg, L; Shapiro, S; Slone, D, 1981)
"The effect of consumption of caffeine-containing coffee on the risk of myocardial infarction in women 30-49 years of age was investigated."3.66Coffee drinking and myocardial infarction in young women. ( Kaufman, DW; Miettinen, OS; Rosenberg, L; Shapiro, S; Slone, D; Stolley, PD, 1980)
"Caffeine does not increase respiration in p27-deficient animals, whereas aged mice display improvement after 10 days of caffeine in drinking water."1.48CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine. ( Abrams, M; Ale-Agha, N; Altschmied, J; Aufenvenne, K; Deenen, R; Dyballa-Rukes, N; Eckermann, O; Fischer, JW; Gonnissen, S; Gorressen, S; Goy, C; Grandoch, M; Haendeler, J; Jakob, S; Jakobs, P; Köhrer, K; Spannbrucker, T; Spyridopoulos, I; Unfried, K; von Ameln, F; Zurek, M, 2018)
"Caffeine is a nonspecific adenosine receptor blocker, and thus drinking CC may block the myocardial protective effects of statins."1.35Caffeinated coffee blunts the myocardial protective effects of statins against ischemia-reperfusion injury in the rat. ( Abu Said, GH; Birnbaum, Y; Hughes, MG; Lin, Y; Manickavasagam, S; McAdoo, DJ; Perez-Polo, RJ; Ye, Y, 2008)
"Four caffeine-treated rats had histologic evidence of acute myocardial infarction which was not found in any of the other rats."1.26Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine. ( Johansson, S, 1981)

Research

Studies (93)

TimeframeStudies, this research(%)All Research%
pre-199041 (44.09)18.7374
1990's13 (13.98)18.2507
2000's28 (30.11)29.6817
2010's10 (10.75)24.3611
2020's1 (1.08)2.80

Authors

AuthorsStudies
Furtado, RHM1
Venkateswaran, RV1
Nicolau, JC2
Gurmu, Y1
Bhatt, DL1
Storey, RF1
Steg, PG1
Magnani, G1
Goto, S1
Dellborg, M1
Kamensky, G1
Isaza, D1
Aylward, P1
Johanson, P1
Bonaca, MP1
Ale-Agha, N1
Goy, C1
Jakobs, P1
Spyridopoulos, I1
Gonnissen, S1
Dyballa-Rukes, N1
Aufenvenne, K1
von Ameln, F1
Zurek, M1
Spannbrucker, T1
Eckermann, O1
Jakob, S1
Gorressen, S1
Abrams, M1
Grandoch, M1
Fischer, JW1
Köhrer, K1
Deenen, R1
Unfried, K1
Altschmied, J1
Haendeler, J1
Lohsoonthorn, V1
Rattananupong, T1
Wynne, K1
Thomas, C1
Chahal, HS1
Berhane, HY1
Mostofsky, E1
Wuttithai, N1
Gelaye, B1
Øyehaug, L1
Loose, KØ1
Jølle, GF1
Røe, ÅT1
Sjaastad, I2
Christensen, G1
Sejersted, OM2
Louch, WE1
Johnsen, AB1
Høydal, M1
Røsbjørgen, R1
Stølen, T1
Wisløff, U1
da Silva, JS1
Pereira, SL1
Maia, Rdo C1
Landgraf, SS1
Caruso-Neves, C1
Kümmerle, AE1
Fraga, CA1
Barreiro, EJ1
Sudo, RT1
Zapata-Sudo, G1
Mackiewicz, U1
Maczewski, M1
Konior, A1
Tellez, JO1
Nowis, D1
Dobrzynski, H1
Boyett, MR1
Lewartowski, B1
Reyes, E1
Loong, CY1
Harbinson, M1
Donovan, J1
Anagnostopoulos, C1
Underwood, SR1
Richardson, T1
Baker, J1
Thomas, PW1
Meckes, C1
Rozkovec, A1
Kerr, D1
Alpert, JS1
Hirose, M1
Stuyvers, BD1
Dun, W1
ter Keurs, HE1
Boyden, PA3
Banko, LT1
Haq, SA1
Rainaldi, DA1
Klem, I1
Siegler, J1
Fogel, J1
Sacchi, TJ1
Heitner, JF1
Biesmans, L1
Macquaide, N1
Heinzel, FR1
Bito, V1
Smith, GL2
Sipido, KR1
Belevych, AE1
Terentyev, D1
Terentyeva, R1
Ho, HT1
Gyorke, I1
Bonilla, IM1
Carnes, CA1
Billman, GE1
Györke, S1
Floegel, A1
Pischon, T1
Bergmann, MM1
Teucher, B1
Kaaks, R1
Boeing, H1
Scott, MJ1
El-Hassan, M1
Khan, AA1
Neary, P1
Duncan, AM1
Cobbe, SM1
Bøkenes, J1
Swift, F1
Wasserstrom, JA1
Tavani, A2
Bertuzzi, M1
Negri, E2
Sorbara, L1
La Vecchia, C3
WENZEL, DG1
MACCARTHY, JD1
RUTLEDGE, CO1
BAUMANN, W1
Myers, MG3
Mukamal, KJ1
Maclure, M1
Muller, JE1
Sherwood, JB1
Mittleman, MA1
Happonen, P2
Voutilainen, S2
Salonen, JT2
Nyska, A1
Murphy, E1
Foley, JF1
Collins, BJ1
Petranka, J1
Howden, R1
Hanlon, P1
Dunnick, JK1
Sudano, I2
Binggeli, C1
Spieker, L1
Lüscher, TF1
Ruschitzka, F1
Noll, G1
Corti, R2
Solenkova, NV1
Solodushko, V1
Cohen, MV1
Downey, JM1
Rempher, KJ1
Azevedo, A1
Barros, H1
Baylin, A2
Hernandez-Diaz, S1
Kabagambe, EK2
Siles, X1
Campos, H2
Siscovick, DS1
Perez, GH1
Romano, BW1
Laranjeira, R1
Tuomainen, TP1
Flammer, AJ1
Culić, V1
Poole, C1
Ye, Y1
Abu Said, GH1
Lin, Y1
Manickavasagam, S1
Hughes, MG1
McAdoo, DJ1
Perez-Polo, RJ1
Birnbaum, Y1
Riksen, NP1
Hausenloy, DJ1
Yellon, DM1
Johansson, S1
Curatolo, PW1
Robertson, D1
James, JE1
Stirling, KP1
Rosenberg, L5
Slone, D2
Shapiro, S5
Kaufman, DW4
Miettinen, OS2
Stolley, PD1
Palmer, JR2
Rao, RS1
D'Avanzo, B1
Franceschi, S2
Gentile, A1
Boutjdir, M2
Assadi, M1
el-Sherif, N2
Willett, WC1
Stampfer, MJ1
Manson, JE1
Colditz, GA1
Rosner, BA1
Speizer, FE1
Hennekens, CH2
Forman, J1
Aizer, A1
Young, CR1
Yamaguchi, F1
Sanbe, A1
Takeo, S1
Rosenkranz, S1
Deutsch, HJ1
Erdmann, E1
Zhang, XQ2
Musch, TI2
Zelis, R1
Cheung, JY2
Ng, YC1
Moore, RL1
Smith, IK1
Pu, J1
Robinson, RB1
Hemzacek, KI1
Furlong, FW1
MacCornack, FA1
Heyden, S4
Tyroler, HA1
Cassel, JC1
Hames, CG1
Becker, C1
Heiss, G1
Johnson, RB1
McCance, DM1
Lukash, WM1
Al-Samarrae, W1
Ma, MC1
Truswell, AS1
Vaisrub, S1
Wolff, G1
Drolette, ME1
Jesse, MJ1
Davies, JE1
Hutchison, GB1
Harris, L2
Grobbee, DE1
Rimm, EB1
Giovannucci, E1
Colditz, G1
Stampfer, M1
Willett, W1
Gough, WB1
Klatsky, AL1
Friedman, GD1
Armstrong, MA1
Leenen, FH1
Grant, DM1
Thandroyen, FT1
McCarthy, J1
Burton, KP1
Opie, LH1
Gardner, PI1
Wit, AL1
Schneider, JR2
Kelly, JP1
Decarli, A1
Pampallona, S1
Tognoni, G1
Werler, MM1
Kaneko, N1
Takeishi, M1
Steinke, J1
Bonk, S1
Stocksmeier, U1
Surawicz, B1
Escher, M1
Fica, V1
Panaitescu, G1
Mătrescu, F1
Haldeman, J1
Olson, PT1
Heinonen, OP1
Schneider, JA1
Sperelakis, N1
Guy-Grand, B1
Dorf, G1
Duchier, J1
Aimez, P1
Bellet, S1
Horstmann, E1
Roman, LR1
DeGuzman, NT1
Kostis, JB1
Capri, C1
Sturm, A1
Scheja, HW1
Puentes, F1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multinational Trial, to Assess the Prevention of Thrombotic Events With Ticagrelor Compared to Placebo on a Background of Acetyl Salicylic Acid (ASA) Therapy in Patients With History of Myoca[NCT01225562]Phase 321,379 participants (Actual)Interventional2010-10-31Completed
Evaluation of Energy Drink Consumption on Electrocardiographic, Vascular and Hematologic Parameters in Young Healthy Volunteers: A Randomized, Double Blind, Active-Controlled, Crossover Study[NCT03021616]2 participants (Actual)Interventional2017-06-26Terminated (stopped due to Results from sister study at University of the Pacific were conclusive.)
[NCT00005243]0 participants Observational1989-04-30Completed
Evaluation of the Effect of Espresso on Platelet Aggregability in Patients With Coronary Artery Disease[NCT04827251]30 participants (Anticipated)Interventional2019-03-18Recruiting
[NCT03308838]4,547 participants (Actual)Observational1994-08-01Completed
The Effect of Metabolism-Boosting Beverages on 24 Hr Energy Expenditure[NCT01029236]30 participants (Actual)Interventional2007-06-30Completed
[NCT00005185]0 participants Observational1986-04-30Completed
Nurses' Health Study (Cardiovascular Component)[NCT00005152]121,700 participants (Actual)Observational1980-08-31Active, not recruiting
[NCT00005122]0 participants Observational1958-07-31Completed
[NCT00005182]50,000 participants (Actual)Observational1985-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Kaplan-Meier Estimate of the Percentage of Patients Who Died From Any Cause Within 3 Years From Randomization

Participants with death from any cause. If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent or the last time point the particapant was known to be alive. Events were adjudicated by a blinded endpoint committee. The Kaplan-Meier estimate reports the percentage of patients who died from any cause within 3 years from randomization (NCT01225562)
Timeframe: Randomization up to 47 months

InterventionPercentage of Patients (Number)
Ticagrelor 90 mg5.1
Ticagrelor 60 mg4.7
Placebo5.2

Kaplan-Meier Estimate of the Percentage of Patients Who Experienced a TIMI Major Bleeding Within 3 Years From First Dose of Study Drug Units: Percentage of Patients

A Thrombolysis in Myocardial Infarction (TIMI) study group major bleeding is defined as any fatal bleeding (leading directly to death within 7 days), any intrcranial bleeding or any clinically overt signs of haemorrhage associated with a drop in Haemoglobin of >= 5g/dL. Events were adjudicated by a clinical events committee. Censoring ocurrs at 7 days following last dose of study drug. The Kaplan-Meier estimate reports the percentage of patients who experienced a TIMI Major bleeding within 3 years from first dose of study drug (NCT01225562)
Timeframe: First dosing up to 48 months

InterventionPercentage of Patients (Number)
Ticagrelor 90 mg2.6
Ticagrelor 60 mg2.3
Placebo1.1

Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death) Within 3 Years From Randomization

Participants with CV death. If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent, non-CV death or at the last time point of complete clinical event assessment. Events were adjudicated by a blinded endpoint committee. The Kaplan-Meier estimate reports the percentage of patients who experienced CV Death within 3 years from randomization (NCT01225562)
Timeframe: Randomization up to 47 months

InterventionPercentage of Patients (Number)
Ticagrelor 90 mg2.9
Ticagrelor 60 mg2.9
Placebo3.4

Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death), Myocardial Infarction (MI) or Stroke Within 3 Years From Randomization

Participants with CV death, MI or Stroke. If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent, non-CV death or at the last time point of complete clinical event assessment. Events were adjudicated by a blinded endpoint committee. The Kaplan-Meier estimate reports the percentage of patients who experienced CV Death, MI or stroke within 3 years from randomization (NCT01225562)
Timeframe: Randomization up to 47 months

InterventionPercentage of Patients (Number)
Ticagrelor 90 mg7.8
Ticagrelor 60 mg7.8
Placebo9.0

Reviews

7 reviews available for caffeine and Cardiovascular Stroke

ArticleYear
Cardiovascular effects of coffee: is it a risk factor?
    Progress in cardiovascular nursing, 2005,Spring, Volume: 20, Issue:2

    Topics: Blood Glucose; Caffeine; Cardiovascular System; Coffee; Cooking; Diabetes Mellitus, Type 1; Drinking

2005
Cardiovascular sequelae of tobacco smoking.
    Critical care nursing clinics of North America, 2006, Volume: 18, Issue:1

    Topics: Aortic Aneurysm, Abdominal; Arrhythmias, Cardiac; Atherosclerosis; Caffeine; Cardiovascular Diseases

2006
The health consequences of caffeine.
    Annals of internal medicine, 1983, Volume: 98, Issue:5 Pt 1

    Topics: Brain; Caffeine; Coffee; Digestive System; Drug Tolerance; Female; Fibrocystic Breast Disease; Hemod

1983
Caffeine: a survey of some of the known and suspected deleterious effects of habitual use.
    British journal of addiction, 1983, Volume: 78, Issue:3

    Topics: Abnormalities, Drug-Induced; Anxiety Disorders; Behavior Therapy; Caffeine; Coffee; Diagnosis, Diffe

1983
Possible psychiatric significance of excessive coffee consumption.
    Canadian Psychiatric Association journal, 1975, Volume: 20, Issue:8

    Topics: Adult; Anxiety Disorders; Blood Pressure; Caffeine; Canada; Cardiovascular System; Cerebrovascular C

1975
Should patients with myocardial infarction receive caffeinated coffee?
    Focus on critical care, 1988, Volume: 15, Issue:1

    Topics: Adult; Aged; Caffeine; Coffee; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarctio

1988
[Coffee-drinking from the medical point of view].
    Schweizerische medizinische Wochenschrift, 1973, Volume: 103, Issue:43

    Topics: Adult; Blood Pressure; Caffeine; Coffee; Diabetes Mellitus; Feeding Behavior; Female; Gout; Health S

1973

Trials

6 trials available for caffeine and Cardiovascular Stroke

ArticleYear
Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial.
    Journal of the American Heart Association, 2020, 05-18, Volume: 9, Issue:10

    Topics: Aged; Aspirin; Beverages; Caffeine; Double-Blind Method; Dual Anti-Platelet Therapy; Dyspnea; Female

2020
Randomized control trial investigating the influence of coffee on heart rate variability in patients with ST-segment elevation myocardial infarction.
    QJM : monthly journal of the Association of Physicians, 2009, Volume: 102, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Caffeine; Coffee; Double-Blind Method; Electro

2009
Incidence of caffeine in serum of patients undergoing dipyridamole myocardial perfusion stress test by an intensive versus routine caffeine history screening.
    The American journal of cardiology, 2010, May-15, Volume: 105, Issue:10

    Topics: Aged; Caffeine; Coronary Disease; Dipyridamole; Drug Interactions; Exercise Test; Female; Hemodynami

2010
High dose caffeine and ventricular arrhythmias.
    The Canadian journal of cardiology, 1990, Volume: 6, Issue:3

    Topics: Aged; Arrhythmias, Cardiac; Caffeine; Cardiac Complexes, Premature; Clinical Trials as Topic; Coffee

1990
Caffeine as a possible cause of ventricular arrhythmias during the healing phase of acute myocardial infarction.
    The American journal of cardiology, 1987, May-01, Volume: 59, Issue:12

    Topics: Arrhythmias, Cardiac; Blood Pressure; Caffeine; Cardiac Complexes, Premature; Double-Blind Method; E

1987
Effects of caffeine ingestion on heart rate, blood pressure, myocardial oxygen consumption, and cardiac rhythm in acute myocardial infarction patients.
    Heart & lung : the journal of critical care, 1987, Volume: 16, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Caffeine; Coronary Care Units; Double-Blind Method;

1987

Other Studies

80 other studies available for caffeine and Cardiovascular Stroke

ArticleYear
CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine.
    PLoS biology, 2018, Volume: 16, Issue:6

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Caffeine; Cardiotonic Agents; Cell Differentiation; Cell

2018
Immediate risk of myocardial infarction following physical exertion, tea, and coffee: A case-crossover study in Thailand.
    PloS one, 2019, Volume: 14, Issue:1

    Topics: Aged; Caffeine; Case-Control Studies; Coffee; Cross-Over Studies; Female; Humans; Male; Middle Aged;

2019
Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity.
    Biophysical journal, 2013, Apr-16, Volume: 104, Issue:8

    Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Signaling; Cytosol; Female; Mice; Mice

2013
Aerobic interval training partly reverse contractile dysfunction and impaired Ca2+ handling in atrial myocytes from rats with post infarction heart failure.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Caffeine; Calcium; Calcium Signaling; Cardiotonic Agents; Electric Stimulation; Exercise Th

2013
N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle.
    Life sciences, 2014, Jan-14, Volume: 94, Issue:1

    Topics: Animals; Caffeine; Calcium; Disease Models, Animal; Exercise Tolerance; Homeostasis; Hydrazones; Mal

2014
Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat.
    Cardiovascular research, 2009, Feb-15, Volume: 81, Issue:3

    Topics: Animals; Caffeine; Calcium; Calcium Signaling; Disease Models, Animal; Down-Regulation; Electric Sti

2009
High-dose adenosine overcomes the attenuation of myocardial perfusion reserve caused by caffeine.
    Journal of the American College of Cardiology, 2008, Dec-09, Volume: 52, Issue:24

    Topics: Adenosine; Aged; Caffeine; Central Nervous System Stimulants; Coffee; Coronary Artery Disease; Coron

2008
"Hey, doc, is it OK for me to drink coffee?".
    The American journal of medicine, 2009, Volume: 122, Issue:7

    Topics: Blood Pressure; Caffeine; Central Nervous System Stimulants; Cholesterol; Coffee; Humans; Myocardial

2009
Function of Ca(2+) release channels in Purkinje cells that survive in the infarcted canine heart: a mechanism for triggered Purkinje ectopy.
    Circulation. Arrhythmia and electrophysiology, 2008, Volume: 1, Issue:5

    Topics: Animals; Arrhythmias, Cardiac; Caffeine; Calcium Channels; Calcium Signaling; Cell Survival; Disease

2008
Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density.
    PloS one, 2011, Volume: 6, Issue:10

    Topics: Animals; Caffeine; Calcium Signaling; Cells, Cultured; Heart Ventricles; Models, Biological; Myocard

2011
Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death.
    Circulation research, 2012, Feb-17, Volume: 110, Issue:4

    Topics: Adrenergic beta-Agonists; Animals; Benzylamines; Caffeine; Calcium Channel Agonists; Calcium Signali

2012
Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:4

    Topics: Adult; Aged; Caffeine; Cardiovascular Diseases; Coffee; Cohort Studies; Diabetes Mellitus, Type 2; F

2012
Myocardial infarction in a young adult following the consumption of a caffeinated energy drink.
    BMJ case reports, 2011, Jun-29, Volume: 2011

    Topics: Caffeine; Energy Drinks; Humans; Male; Myocardial Infarction; Young Adult

2011
Assessment of sarcoplasmic reticulum Ca(2+) flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction.
    Pflugers Archiv : European journal of physiology, 2002, Volume: 444, Issue:3

    Topics: Animals; Biological Transport; Caffeine; Calcium; Calcium-Transporting ATPases; Disease Models, Anim

2002
Normal contractions triggered by I(Ca,L) in ventricular myocytes from rats with postinfarction CHF.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:3

    Topics: Action Potentials; Animals; Caffeine; Calcium; Calcium Channels, L-Type; Calcium-Binding Proteins; C

2002
Alcohol, smoking, coffee and risk of non-fatal acute myocardial infarction in Italy.
    European journal of epidemiology, 2001, Volume: 17, Issue:12

    Topics: Adult; Aged; Alcohol Drinking; Caffeine; Case-Control Studies; Chi-Square Distribution; Coffee; Fema

2001
EVALUATION OF CAFFEINE AND OUABAIN AS PERMISSIVE AGENTS IN THE PRODUCTION OF MYOCARDIAL NECROSIS.
    Journal of pharmaceutical sciences, 1964, Volume: 53

    Topics: Animals; Blood Coagulation; Blood Pressure; Caffeine; Cholesterol; Hypercholesterolemia; Myocardial

1964
[On the pathogenesis and therapy of myocardial infarct, with special reference to the author's experience with injections of impletol and strophanthin].
    Arztliche Wochenschrift, 1951, Oct-12, Volume: 6, Issue:41

    Topics: Caffeine; Coronary Disease; Drug Combinations; Humans; Myocardial Infarction; Procaine; Strophanthin

1951
Effect of caffeine on blood pressure beyond the laboratory.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:4

    Topics: Adult; Age Factors; Beverages; Blood Pressure; Caffeine; Capsules; Clinical Trials as Topic; Drug Ad

2004
Caffeinated coffee consumption and mortality after acute myocardial infarction.
    American heart journal, 2004, Volume: 147, Issue:6

    Topics: Aged; Alcohol Drinking; Caffeine; Carbonated Beverages; Coffee; Cohort Studies; Comorbidity; Diabete

2004
Coffee drinking is dose-dependently related to the risk of acute coronary events in middle-aged men.
    The Journal of nutrition, 2004, Volume: 134, Issue:9

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Coffee; Cohort Studies; Cooking; Diet Records; D

2004
Acute hemorrhagic myocardial necrosis and sudden death of rats exposed to a combination of ephedrine and caffeine.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 83, Issue:2

    Topics: Acute Disease; Administration, Oral; Adrenergic Agents; Animals; Caffeine; Caspase 3; Caspases; Cent

2005
Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:1

    Topics: Acetamides; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Androstadienes; An

2006
Coffee and myocardial infarction: heterogeneity of an association in Portuguese men.
    European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 2006, Volume: 13, Issue:2

    Topics: Adult; Body Size; Caffeine; Coffee; Energy Intake; Humans; Male; Myocardial Infarction; Portugal; Ri

2006
Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction.
    Epidemiology (Cambridge, Mass.), 2006, Volume: 17, Issue:5

    Topics: Acute Disease; Aged; Caffeine; Central Nervous System Stimulants; Coffee; Costa Rica; Cross-Over Stu

2006
Triggers of clinical coronary heart disease.
    Epidemiology (Cambridge, Mass.), 2006, Volume: 17, Issue:5

    Topics: Acute Disease; Caffeine; Central Nervous System Stimulants; Humans; Myocardial Infarction; Reproduci

2006
Smoking-associated factors in myocardial infarction and unstable angina: do gender differences exist?
    Addictive behaviors, 2007, Volume: 32, Issue:6

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Angina, Unstable; Attitude; Caffeine; Drinking Behavior

2007
Catechol-o-methyltransferase gene polymorphism modifies the effect of coffee intake on incidence of acute coronary events.
    PloS one, 2006, Dec-27, Volume: 1

    Topics: Adult; Aged; Base Sequence; Caffeine; Catechol O-Methyltransferase; Catecholamines; Coffee; Cohort S

2006
Coffee and myocardial infarction.
    Epidemiology (Cambridge, Mass.), 2007, Volume: 18, Issue:2

    Topics: Blood Pressure; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Coffee; Feeding B

2007
Coffee and myocardial infarction.
    Epidemiology (Cambridge, Mass.), 2007, Volume: 18, Issue:2

    Topics: Caffeine; Central Nervous System Stimulants; Coffee; Confounding Factors, Epidemiologic; Eating; Fee

2007
Nonfatal acute myocardial infarction in Costa Rica: modifiable risk factors, population-attributable risks, and adherence to dietary guidelines.
    Circulation, 2007, Mar-06, Volume: 115, Issue:9

    Topics: Abdominal Fat; Adult; Aged; Caffeine; Case-Control Studies; Costa Rica; Diet; Female; Guidelines as

2007
Coffee and myocardial infarction.
    Epidemiology (Cambridge, Mass.), 2007, Volume: 18, Issue:4

    Topics: Caffeine; Coffee; Cross-Over Studies; Humans; Myocardial Infarction; Odds Ratio; Time Factors

2007
Caffeinated coffee blunts the myocardial protective effects of statins against ischemia-reperfusion injury in the rat.
    Cardiovascular drugs and therapy, 2008, Volume: 22, Issue:4

    Topics: Administration, Oral; Animals; Atorvastatin; Blood Pressure; Caffeine; Coffee; Disease Models, Anima

2008
Wake up and smell the coffee: yet another no go for cardiac patients? : editorial to "caffeinated coffee blunts the myocardial protective effects of statins against ischemia-reperfusion injury in the rat" by Ye et al.
    Cardiovascular drugs and therapy, 2008, Volume: 22, Issue:4

    Topics: Administration, Oral; Animals; Atorvastatin; Caffeine; Coffee; Food-Drug Interactions; Heptanoic Aci

2008
Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.
    Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1981, Volume: 89, Issue:3

    Topics: Acetaminophen; Animals; Antipyrine; Caffeine; Cardiovascular Diseases; Heart; Male; Myocardial Infar

1981
Case-control studies on the acute effects of coffee upon the risk of myocardial infarction: problems in the selection of a hospital control series.
    American journal of epidemiology, 1981, Volume: 113, Issue:6

    Topics: Acute Disease; Adult; Caffeine; Chronic Disease; Coffee; Feeding Behavior; Female; Hospitalization;

1981
Coffee drinking and myocardial infarction in young women.
    American journal of epidemiology, 1980, Volume: 111, Issue:6

    Topics: Acute Disease; Adult; Caffeine; Coffee; Epidemiologic Methods; Female; Humans; Middle Aged; Myocardi

1980
Coffee consumption and myocardial infarction in women.
    American journal of epidemiology, 1995, Apr-15, Volume: 141, Issue:8

    Topics: Aged; Angina Pectoris; Caffeine; Case-Control Studies; Coffee; Female; Humans; Hypertension; Logisti

1995
Decaffeinated coffee and acute myocardial infarction. A case-control study in Italian women.
    Annals of epidemiology, 1993, Volume: 3, Issue:6

    Topics: Adult; Aged; Caffeine; Case-Control Studies; Coffee; Female; Humans; Italy; Middle Aged; Myocardial

1993
Electrophysiologic effects of cocaine on subendocardial Purkinje fibers surviving 1 day of myocardial infarction.
    Journal of cardiovascular electrophysiology, 1995, Volume: 6, Issue:9

    Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Caffeine; Calcium; Central Nervous System S

1995
Coffee consumption and coronary heart disease in women. A ten-year follow-up.
    JAMA, 1996, Feb-14, Volume: 275, Issue:6

    Topics: Adult; Caffeine; Coffee; Coronary Disease; Female; Follow-Up Studies; Humans; Middle Aged; Multivari

1996
Myocardial infarction resulting from caffeine overdose in an anorectic woman.
    Annals of emergency medicine, 1997, Volume: 29, Issue:1

    Topics: Adult; Bulimia; Caffeine; Central Nervous System Stimulants; Drug Overdose; Female; Humans; Myocardi

1997
Cardiac sarcoplasmic reticular function in rats with chronic heart failure following myocardial infarction.
    Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:2

    Topics: Animals; Caffeine; Calcium; Cell Membrane; Central Nervous System Stimulants; Heart Failure; Hemodyn

1997
[33-year-old patient with postpartum myocardial infarct].
    Der Internist, 1997, Volume: 38, Issue:6

    Topics: Adult; Aminopyrine; Caffeine; Coronary Angiography; Coronary Thrombosis; Coronary Vasospasm; Drug Co

1997
Effects of impaired Ca2+ homeostasis on contraction in postinfarction myocytes.
    Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 86, Issue:3

    Topics: Animals; Caffeine; Calcium; Calcium Channels; Central Nervous System Stimulants; Electric Stimulatio

1999
In situ SR function in postinfarction myocytes.
    Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 87, Issue:6

    Topics: Animals; Caffeine; Calcium; Calcium-Transporting ATPases; Cell Membrane Permeability; Heart; Intrace

1999
Trouble brewing. A steaming cup is a great comfort, but consider the effects of unfiltered coffee on the heart.
    Time, 2000, Feb-07, Volume: 155, Issue:5

    Topics: Caffeine; Coffee; Heart; Humans; Myocardial Infarction

2000
Abnormalities in Ca(i)handling in myocytes that survive in the infarcted heart are not just due to alterations in repolarization.
    Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:8

    Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Cells, Cultured; Central Nervous System Stimul

2000
Dietary protocol for the patient who has suffered a myocardial infarction.
    Journal of the American Dietetic Association, 1978, Volume: 72, Issue:2

    Topics: Caffeine; Cardiovascular Diseases; Cholesterol, Dietary; Feeding Behavior; Humans; Menu Planning; My

1978
The effects of coffee drinking on the cardiovascular system: experimental and epidemiological research.
    Preventive medicine, 1977, Volume: 6, Issue:1

    Topics: Adolescent; Adult; Aged; Blood Pressure; Caffeine; Cardiovascular System; Chlorogenic Acid; Coffee;

1977
Coffee and cardiovascular disease.
    The Medical letter on drugs and therapeutics, 1977, Aug-12, Volume: 19, Issue:16

    Topics: Acute Disease; Beverages; Caffeine; Cardiovascular Diseases; Coffee; Heart Rate; Humans; Male; Myoca

1977
Coffee consumption and mortality in a community study--Evans Co., Ga.
    Zeitschrift fur Ernahrungswissenschaft, 1976, Volume: 15, Issue:2

    Topics: Black People; Caffeine; Cerebrovascular Disorders; Coffee; Coronary Disease; Female; Georgia; Habits

1976
Coffee treat or trick?
    American family physician, 1975, Volume: 11, Issue:6

    Topics: Adult; Caffeine; Coffee; Duodenal Ulcer; Gastric Juice; Gastric Mucosa; Humans; Infant, Newborn; Myo

1975
Methylxanthine consumption from coffee and tea.
    The Proceedings of the Nutrition Society, 1975, Volume: 34, Issue:1

    Topics: Caffeine; Coffee; Myocardial Infarction; Tea; Theobromine; Xanthines

1975
Editorial: A break for the coffee-break.
    JAMA, 1975, Mar-03, Volume: 231, Issue:9

    Topics: Adult; Aged; Caffeine; Coffee; Coronary Disease; Death, Sudden; Heart; Hemodynamics; Humans; Male; M

1975
[Coffee from medical point of view].
    Medizinische Monatsschrift, 1975, Volume: 29, Issue:11

    Topics: Caffeine; Coffee; Energy Metabolism; Humans; Hypertension; Mutagens; Myocardial Infarction

1975
Coffee drinking and death due to coronary heart disease.
    The New England journal of medicine, 1976, Mar-18, Volume: 294, Issue:12

    Topics: Adult; Aged; Angina Pectoris; Body Weight; Caffeine; Coffee; Coronary Disease; Diabetes Complication

1976
Coffee, caffeine, and cardiovascular disease in men.
    The New England journal of medicine, 1990, Oct-11, Volume: 323, Issue:15

    Topics: Adult; Aged; Caffeine; Cardiovascular Diseases; Cerebrovascular Disorders; Coffee; Coronary Disease;

1990
Effects of caffeine and ryanodine on delayed afterdepolarizations and sustained rhythmic activity in 1-day-old myocardial infarction in the dog.
    Circulation, 1990, Volume: 81, Issue:4

    Topics: Alkaloids; Animals; Caffeine; Dogs; Electrophysiology; Myocardial Infarction; Osmolar Concentration;

1990
Coffee use prior to myocardial infarction restudied: heavier intake may increase the risk.
    American journal of epidemiology, 1990, Volume: 132, Issue:3

    Topics: Aged; Alcohol Drinking; Blood Glucose; Blood Pressure; Caffeine; California; Cholesterol; Coffee; Ep

1990
Ryanodine and caffeine prevent ventricular arrhythmias during acute myocardial ischemia and reperfusion in rat heart.
    Circulation research, 1988, Volume: 62, Issue:2

    Topics: Alkaloids; Animals; Arrhythmias, Cardiac; Caffeine; Calcium; Coronary Circulation; Cyclic AMP; Energ

1988
Action potentials of cardiac muscle in healing infarcts: response to norepinephrine and caffeine.
    Journal of molecular and cellular cardiology, 1988, Volume: 20, Issue:6

    Topics: Action Potentials; Animals; Caffeine; Cyclic AMP; Dogs; Heart; Isotonic Solutions; Membrane Potentia

1988
Coffee drinking and nonfatal myocardial infarction in men under 55 years of age.
    American journal of epidemiology, 1988, Volume: 128, Issue:3

    Topics: Adult; Caffeine; Coffee; Humans; Male; Middle Aged; Myocardial Infarction; Smoking; Tea; Time Factor

1988
Risk factors for myocardial infarction in young women.
    American journal of epidemiology, 1987, Volume: 125, Issue:5

    Topics: Adult; Caffeine; Contraceptives, Oral; Diabetes Complications; Epidemiologic Methods; Family; Female

1987
Coffee drinking and myocardial infarction in young women: an update.
    American journal of epidemiology, 1987, Volume: 126, Issue:1

    Topics: Adult; Caffeine; Female; Humans; Middle Aged; Myocardial Infarction; Smoking

1987
New theory on the pathogenesis of acute myocardial infarction.
    Japanese circulation journal, 1986, Volume: 50, Issue:2

    Topics: Adult; Aged; Animals; Caffeine; Calcium; Cell Survival; Coronary Vessels; Dogs; Electrocardiography;

1986
Coffee drinking and acute myocardial infarction.
    Lancet (London, England), 1973, Feb-03, Volume: 1, Issue:7797

    Topics: Acute Disease; Adult; Caffeine; Coffee; Humans; Lipids; Myocardial Infarction

1973
[Do correlations exist between coffee drinking and myocardial infarction? (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1974, Nov-15, Volume: 116, Issue:46

    Topics: Adolescent; Adult; Aged; Caffeine; Coffee; Female; Food Preferences; Germany, West; Health Surveys;

1974
Editorial: Calcium responses ("calcium spikes").
    The American journal of cardiology, 1974, May-06, Volume: 33, Issue:5

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Caffeine; Calcium; Coronary Disease; Cyclic AMP; E

1974
[Effects of coffee during good health and in disease from the medical standpoint].
    Minerva medica, 1974, Jan-17, Volume: 65, Issue:3

    Topics: Acute Disease; Aged; Blood Pressure; Caffeine; Cerebrovascular Disorders; Coffee; Diabetes Mellitus;

1974
[General and specific circumstances in pathogenesis of paroxysmal tachycardias].
    Medicina interna, 1972, Volume: 24, Issue:10

    Topics: Acid-Base Equilibrium; Caffeine; Catecholamines; Digitalis Glycosides; Electrolytes; Fatty Acids; He

1972
Letter: Coffee and myocardial infarction.
    The New England journal of medicine, 1973, Nov-01, Volume: 289, Issue:18

    Topics: Caffeine; Coffee; Humans; Myocardial Infarction; Personality; Tea

1973
Classes for coronary care patients.
    Journal of the American Dietetic Association, 1973, Volume: 63, Issue:6

    Topics: Caffeine; Cholesterol, Dietary; Coronary Disease; Diet Therapy; Dietary Fats; Myocardial Infarction;

1973
[Coffee and coronary disease].
    Duodecim; laaketieteellinen aikakauskirja, 1973, Volume: 89, Issue:23

    Topics: Acute Disease; Caffeine; Coffee; Coronary Disease; Fibrinolysis; Humans; Myocardial Infarction

1973
The demonstration of energy dependence of the isoproterenol-induced transcellular Ca2+ current in isolated perfused guinea pig hearts--an explanation for mechanical failure of ischemic myocardium.
    The Journal of surgical research, 1974, Volume: 16, Issue:4

    Topics: Action Potentials; Animals; Biological Transport; Caffeine; Calcium; Cell Membrane; Cell Membrane Pe

1974
[Dietetics and nutrition in 1972].
    La Revue du praticien, 1972, Feb-21, Volume: 22, Issue:6

    Topics: Adipose Tissue; Alcoholic Intoxication; Anorexia Nervosa; Caffeine; Calcium; Catecholamines; Coffee;

1972
Effect of caffeine on the ventricular fibrillation threshold in normal dogs and dogs with acute myocardial infarction.
    American heart journal, 1972, Volume: 84, Issue:2

    Topics: Animals; Benzoates; Caffeine; Dogs; Heart; Myocardial Infarction; Propranolol; Sodium; Ventricular F

1972
[Coffee consumption and myocardial infarct].
    Cardiologia pratica, 1969, Volume: 20, Issue:5

    Topics: Caffeine; Catecholamines; Cholesterol; Coffee; Humans; Lipid Metabolism; Myocardial Infarction

1969
[Differential diagnosis of increased catecholamine excretion in arterial hypertension].
    Deutsche medizinische Wochenschrift (1946), 1970, Apr-17, Volume: 95, Issue:16

    Topics: Adrenal Gland Neoplasms; Adrenal Glands; Arteries; Asthma; Caffeine; Catecholamines; Diagnosis, Diff

1970
[The BBC study. Applied epidemiology of ischemic heart diseases].
    Archiv fur Kreislaufforschung, 1967, Volume: 53, Issue:1

    Topics: Adult; Body Weight; Caffeine; Cholesterol; Coronary Disease; Epidemiologic Methods; Hematocrit; Huma

1967