caffeine has been researched along with Cancer of Lung in 53 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "We analyzed retrospectively overall survival and some prognostic factors for 41 patients with osteosarcoma/pulmonary metastases who were treated with caffeine-potentiated chemotherapy between 1990 and 2006." | 7.75 | Caffeine-potentiated chemotherapy for metastatic osteosarcoma. ( Hayashi, K; Kimura, H; Nishida, H; Ohnari, I; Shirai, T; Takeuchi, A; Tomita, K; Tsuchiya, H, 2009) |
| "We investigated p53-dependent and -independent molecular events associated with cell cycle alteration and cell death in human lung adenocarcinoma A549 cells using cryptolepine, a DNA-damaging agent." | 7.73 | Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells. ( Gooderham, NJ; Zhu, H, 2006) |
| "The present study investigated the inhibitory effects of Polyphenon E [a standardized green tea polyphenol preparation containing 65% (-)-epigallocatechin-3-gallate] and caffeine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumor progression from adenoma to adenocarcinoma." | 7.73 | Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. ( Hao, X; Liao, J; Lu, G; Reuhl, KR; Yang, CS; Yang, G, 2006) |
| "Lung adenomas were induced in strain A mice by chronic treatment with N-nitroso compounds (given in drinking water) and with amines or ureas in food plus NaNO2 in drinking water." | 7.65 | Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds: effect of ascorbate, gallic acid, thiocyanate, and caffeine. ( Cardesa, A; Mirvish, SS; Shubik, P; Wallcave, L, 1975) |
| " For combined treatment with caffeine and paclitaxel, added caffeine reduced the cytotoxic effect of paclitaxel not only in dose-response but also in time-response curves." | 5.32 | Caffeine diminishes cytotoxic effects of paclitaxel on a human lung adenocarcinoma cell line. ( Akimoto, T; Kitamoto, Y; Mitsuhashi, N; Nakano, T; Sakurai, H, 2003) |
| "We analyzed retrospectively overall survival and some prognostic factors for 41 patients with osteosarcoma/pulmonary metastases who were treated with caffeine-potentiated chemotherapy between 1990 and 2006." | 3.75 | Caffeine-potentiated chemotherapy for metastatic osteosarcoma. ( Hayashi, K; Kimura, H; Nishida, H; Ohnari, I; Shirai, T; Takeuchi, A; Tomita, K; Tsuchiya, H, 2009) |
| "We investigated p53-dependent and -independent molecular events associated with cell cycle alteration and cell death in human lung adenocarcinoma A549 cells using cryptolepine, a DNA-damaging agent." | 3.73 | Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells. ( Gooderham, NJ; Zhu, H, 2006) |
| "The present study investigated the inhibitory effects of Polyphenon E [a standardized green tea polyphenol preparation containing 65% (-)-epigallocatechin-3-gallate] and caffeine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumor progression from adenoma to adenocarcinoma." | 3.73 | Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. ( Hao, X; Liao, J; Lu, G; Reuhl, KR; Yang, CS; Yang, G, 2006) |
| " In this study, we examined the effect of CYP1A2 activity using a urinary caffeine metabolic ratio assay for 54 Chinese women with newly diagnosed lung cancer (including 28 adenocarcinomas) and 174 hospital controls." | 3.71 | Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in Singapore. ( Eng, P; Lee, EJ; Lee, HP; Poh, WT; Seow, A; Tan, WC; Teh, M; Wang, YT; Zhao, B, 2001) |
| " injection of caffeine (8, 20, and 40 mg/kg) 3 times weekly for 8 weeks suppressed the development of spontaneous pulmonary adenomas in strain A mice." | 3.66 | Inhibiting effect of caffeine on spontaneous and urethan-induced lung tumors in strain A mice. ( Shimkin, MB; Theiss, JC, 1978) |
| "The therapeutic usefulness of chlorpromazine (CPZ) and caffeine (CAF) in combination with selected nitrosoureas was investigated in mice bearing L1210 leukemia, Lewis lung carcinoma, and B16 melanoma." | 3.66 | Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors. ( Dykes, DJ; Laster, WR; Rose, WC; Schabel, FM; Trader, MW, 1978) |
| "Lung adenomas were induced in strain A mice by chronic treatment with N-nitroso compounds (given in drinking water) and with amines or ureas in food plus NaNO2 in drinking water." | 3.65 | Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds: effect of ascorbate, gallic acid, thiocyanate, and caffeine. ( Cardesa, A; Mirvish, SS; Shubik, P; Wallcave, L, 1975) |
| "The role of tea in protection against cancer has been supported by ample evidence from studies in cell culture and animal models." | 2.42 | Tea and cancer prevention: studies in animals and humans. ( Chung, FL; Herzog, CR; Schwartz, J; Yang, YM, 2003) |
| "Lung cancer is recognized as a major cause of mortality worldwide owing to its metastatic activity." | 1.62 | Caffeine Induces G0/G1 Cell Cycle Arrest and Inhibits Migration through Integrin αv, β3, and FAK/Akt/c-Myc Signaling Pathway. ( Aksorn, N; Chanvorachote, P; Meisaprow, P; Sukprasansap, M; Vinayanuwattikun, C, 2021) |
| " In this work, we reported a novel kind of BiOI@CuS nanoparticle to achieve safe and effective therapy of lung cancer by co-loading hydrochloric acid doxorubicin (DOX) and aspirin phenacetin and caffeine (APC)." | 1.51 | Construction of DOX/APC co-loaded BiOI@CuS NPs for safe and highly effective CT imaging and chemo-photothermal therapy of lung cancer. ( Cheng, J; He, D; Huang, G; Li, W; Wang, R; Zhang, Y; Zhu, J, 2019) |
| "Caffeine intake was not associated with cancer risk in a dose-response manner." | 1.42 | Coffee, tea, caffeine intake, and the risk of cancer in the PLCO cohort. ( Boffetta, P; Buys, SS; Galeone, C; Gren, L; Hashibe, M; La Vecchia, C; Zhang, ZF, 2015) |
| " For combined treatment with caffeine and paclitaxel, added caffeine reduced the cytotoxic effect of paclitaxel not only in dose-response but also in time-response curves." | 1.32 | Caffeine diminishes cytotoxic effects of paclitaxel on a human lung adenocarcinoma cell line. ( Akimoto, T; Kitamoto, Y; Mitsuhashi, N; Nakano, T; Sakurai, H, 2003) |
| "Hyperoxia has been shown to cause DNA damage resulting in growth arrest of cells in p53-dependent, as well as p53-independent, pathways." | 1.32 | Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites. ( Das, KC; Dashnamoorthy, R, 2004) |
| "Caffeine treatment could bypass the G2/M block in DLKP-SQ cells." | 1.31 | Altered cell cycle response of drug-resistant lung carcinoma cells to doxorubicin. ( Clynes, M; Coyle, S; Heenan, M; O'Loughlin, C, 2000) |
| "The Caffeine treated metastatic tumour bearing animals significantly (p<0." | 1.31 | Effect of Caffeine, a xanthine derivative, in the inhibition of experimental lung metastasis induced by B16F10 melanoma cells. ( Gude, RP; Menon, LG; Rao, SG, 2001) |
| "Caffeine is a model radiosensitizing agent that is thought to work by abrogating the radiation-induced G(2)-phase checkpoint." | 1.31 | Caffeine induces TP53-independent G(1)-phase arrest and apoptosis in human lung tumor cells in a dose-dependent manner. ( Martinez, JD; Qi, W; Qiao, D, 2002) |
| "Theophylline- and caffeine-treated B16-F10 cells exhibited low adhesion to laminin/collagen type IV and reduced invasion through Matrigel in an in vitro assay." | 1.30 | Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation. ( Abbruzzese, A; Autuori-Pezzoli, V; Beninati, S; Cardinali, M; Kleinman, HK; Lentini, A; Mattioli, P; Nicolini, L; Pietrini, A, 1998) |
| " D0 calculated from the dose-response curve for LDRI combined with 41 degrees C was 3." | 1.30 | Interaction between low dose-rate irradiation, mild hyperthermia and low-dose caffeine in a human lung cancer cell line. ( Akimoto, T; Hayakawa, K; Ishikawa, H; Kitamoto, Y; Maebayashi, K; Mitsuhashi, N; Murata, O; Niibe, H; Sakurai, H; Tamaki, Y, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (22.64) | 18.7374 |
| 1990's | 13 (24.53) | 18.2507 |
| 2000's | 18 (33.96) | 29.6817 |
| 2010's | 6 (11.32) | 24.3611 |
| 2020's | 4 (7.55) | 2.80 |
| Authors | Studies |
|---|---|
| Qi, Q | 1 |
| Obianyo, O | 1 |
| Du, Y | 1 |
| Fu, H | 1 |
| Li, S | 1 |
| Ye, K | 1 |
| Meisaprow, P | 1 |
| Aksorn, N | 1 |
| Vinayanuwattikun, C | 1 |
| Chanvorachote, P | 1 |
| Sukprasansap, M | 1 |
| Eguchi, H | 1 |
| Kimura, R | 1 |
| Onuma, S | 1 |
| Ito, A | 1 |
| Yu, Y | 1 |
| Yoshino, Y | 1 |
| Matsunaga, T | 1 |
| Endo, S | 1 |
| Ikari, A | 1 |
| Zhang, Y | 1 |
| Wang, R | 1 |
| Li, W | 1 |
| Huang, G | 1 |
| Zhu, J | 1 |
| Cheng, J | 1 |
| He, D | 1 |
| Steiner, B | 1 |
| Ferrucci, LM | 1 |
| Mirabello, L | 1 |
| Lan, Q | 1 |
| Hu, W | 1 |
| Liao, LM | 1 |
| Savage, SA | 1 |
| De Vivo, I | 1 |
| Hayes, RB | 1 |
| Rajaraman, P | 1 |
| Huang, WY | 1 |
| Freedman, ND | 1 |
| Loftfield, E | 1 |
| Xu, H | 1 |
| Wang, L | 1 |
| Shi, B | 1 |
| Hu, L | 1 |
| Gan, C | 1 |
| Wang, Y | 1 |
| Xiang, Z | 1 |
| Wang, X | 1 |
| Sheng, J | 1 |
| Parra-Guillen, ZP | 1 |
| Berger, PB | 1 |
| Haschke, M | 1 |
| Donzelli, M | 1 |
| Winogradova, D | 1 |
| Pfister, B | 1 |
| Früh, M | 1 |
| Gillessen, S | 1 |
| Krähenbühl, S | 1 |
| Kloft, C | 1 |
| Joerger, M | 1 |
| Igarashi, K | 1 |
| Yamamoto, N | 1 |
| Shirai, T | 2 |
| Nishida, H | 2 |
| Hayashi, K | 2 |
| Tanzawa, Y | 1 |
| Kimura, H | 2 |
| Takeuchi, A | 2 |
| Miwa, S | 1 |
| Inatani, H | 1 |
| Shimozaki, S | 1 |
| Kato, T | 1 |
| Tsuchiya, H | 2 |
| Hashibe, M | 1 |
| Galeone, C | 1 |
| Buys, SS | 1 |
| Gren, L | 1 |
| Boffetta, P | 1 |
| Zhang, ZF | 1 |
| La Vecchia, C | 1 |
| Sabisz, M | 1 |
| Skladanowski, A | 1 |
| Ohnari, I | 1 |
| Tomita, K | 1 |
| Gervasini, G | 1 |
| Ghotbi, R | 1 |
| Aklillu, E | 1 |
| San Jose, C | 1 |
| Cabanillas, A | 1 |
| Kishikawa, J | 1 |
| Benitez, J | 1 |
| Carrillo, JA | 1 |
| Kitamoto, Y | 2 |
| Sakurai, H | 2 |
| Mitsuhashi, N | 2 |
| Akimoto, T | 2 |
| Nakano, T | 1 |
| Das, KC | 1 |
| Dashnamoorthy, R | 1 |
| Chung, FL | 3 |
| Schwartz, J | 1 |
| Herzog, CR | 1 |
| Yang, YM | 1 |
| Roberson, RS | 1 |
| Kussick, SJ | 1 |
| Vallieres, E | 1 |
| Chen, SY | 1 |
| Wu, DY | 1 |
| Yang, H | 1 |
| Rouse, J | 1 |
| Lukes, L | 1 |
| Lancaster, M | 1 |
| Veenstra, T | 1 |
| Zhou, M | 1 |
| Shi, Y | 1 |
| Park, YG | 1 |
| Hunter, K | 1 |
| Baker, JA | 1 |
| McCann, SE | 1 |
| Reid, ME | 1 |
| Nowell, S | 1 |
| Beehler, GP | 1 |
| Moysich, KB | 1 |
| Al-Wadei, HA | 1 |
| Takahashi, T | 1 |
| Schuller, HM | 1 |
| Zhu, H | 1 |
| Gooderham, NJ | 1 |
| Malki, AM | 1 |
| Gentry, J | 1 |
| Evans, SC | 1 |
| Eymin, B | 1 |
| Claverie, P | 1 |
| Salon, C | 1 |
| Leduc, C | 1 |
| Col, E | 1 |
| Brambilla, E | 1 |
| Khochbin, S | 1 |
| Gazzeri, S | 1 |
| Lu, G | 1 |
| Liao, J | 1 |
| Yang, G | 1 |
| Reuhl, KR | 1 |
| Hao, X | 1 |
| Yang, CS | 1 |
| Tatur, S | 1 |
| Groulx, N | 1 |
| Orlov, SN | 1 |
| Grygorczyk, R | 1 |
| Nomura, T | 4 |
| Armuth, V | 1 |
| Berenblum, I | 1 |
| Dahl, GA | 1 |
| Miller, EC | 1 |
| Miller, JA | 1 |
| Hata, S | 1 |
| Enomoto, T | 1 |
| Tanaka, H | 1 |
| Shibata, K | 1 |
| Russell, KJ | 1 |
| Wiens, LW | 1 |
| Demers, GW | 1 |
| Galloway, DA | 1 |
| Plon, SE | 1 |
| Groudine, M | 1 |
| Tsai, CM | 1 |
| Perng, RP | 1 |
| Chen, MH | 1 |
| Jan, YH | 1 |
| Hung, MC | 1 |
| Ku, TY | 1 |
| Chang, KT | 1 |
| Clunes, MT | 1 |
| Kemp, PJ | 1 |
| Ogasawara, H | 1 |
| Nishio, K | 1 |
| Ishida, T | 1 |
| Arioka, H | 1 |
| Fukuoka, K | 1 |
| Saijo, N | 1 |
| Lentini, A | 1 |
| Kleinman, HK | 1 |
| Mattioli, P | 1 |
| Autuori-Pezzoli, V | 1 |
| Nicolini, L | 1 |
| Pietrini, A | 1 |
| Abbruzzese, A | 1 |
| Cardinali, M | 1 |
| Beninati, S | 1 |
| Wang, M | 1 |
| Rivenson, A | 1 |
| Iatropoulos, MJ | 1 |
| Reinhardt, JC | 1 |
| Pittman, B | 1 |
| Ho, CT | 2 |
| Amin, SG | 2 |
| Shafer, SH | 1 |
| Phelps, SH | 1 |
| Williams, CL | 1 |
| Tamaki, Y | 1 |
| Murata, O | 1 |
| Maebayashi, K | 1 |
| Ishikawa, H | 1 |
| Hayakawa, K | 1 |
| Niibe, H | 1 |
| O'Loughlin, C | 1 |
| Heenan, M | 1 |
| Coyle, S | 1 |
| Clynes, M | 1 |
| Seow, A | 1 |
| Zhao, B | 1 |
| Lee, EJ | 1 |
| Poh, WT | 1 |
| Teh, M | 1 |
| Eng, P | 1 |
| Wang, YT | 1 |
| Tan, WC | 1 |
| Lee, HP | 1 |
| Gude, RP | 1 |
| Menon, LG | 1 |
| Rao, SG | 1 |
| Qi, W | 1 |
| Qiao, D | 1 |
| Martinez, JD | 1 |
| Curtis-Prior, PB | 1 |
| Gibbons, JR | 1 |
| Chan, YH | 1 |
| Theiss, JC | 1 |
| Shimkin, MB | 1 |
| Rose, WC | 1 |
| Trader, MW | 1 |
| Dykes, DJ | 1 |
| Laster, WR | 1 |
| Schabel, FM | 1 |
| Mirvish, SS | 1 |
| Cardesa, A | 1 |
| Wallcave, L | 1 |
| Shubik, P | 1 |
| Mamada, A | 1 |
| Miura, K | 1 |
| Tsunoda, K | 1 |
| Hirose, I | 1 |
| Furuya, M | 1 |
| Kondo, S | 1 |
| Sherson, D | 1 |
| Sigsgaard, T | 1 |
| Overgaard, E | 1 |
| Loft, S | 1 |
| Poulsen, HE | 1 |
| Jongeneelen, FJ | 1 |
| Xu, Y | 1 |
| Han, C | 1 |
| Yun, TK | 1 |
| Ohsaki, Y | 1 |
| Ishida, S | 1 |
| Fujikane, T | 1 |
| Akiba, Y | 1 |
| Osanai, S | 1 |
| Onodera, S | 1 |
| Roots, I | 1 |
| Drakoulis, N | 1 |
| Ploch, M | 1 |
| Heinemeyer, G | 1 |
| Loddenkemper, R | 1 |
| Minks, T | 1 |
| Nitz, M | 1 |
| Otte, F | 1 |
| Koch, M | 1 |
| Murad, F | 1 |
| Pak, CY | 1 |
2 reviews available for caffeine and Cancer of Lung
| Article | Year |
|---|---|
Tea and cancer prevention: studies in animals and humans.
Topics: Animals; Apoptosis; Caffeine; Catechin; Clinical Trials as Topic; Flavonoids; Humans; Lung Neoplasms | 2003 |
Xeroderma pigmentosum variant associated with multiple skin cancers and a lung cancer.
Topics: Adenocarcinoma, Papillary; Age Factors; Aged; Caffeine; Carcinoma, Squamous Cell; Cell Survival; Hum | 1992 |
1 trial available for caffeine and Cancer of Lung
| Article | Year |
|---|---|
Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment.
Topics: Aged; Antineoplastic Agents; Caffeine; Carcinoma, Non-Small-Cell Lung; Chromatography, Liquid; Cytoc | 2017 |
50 other studies available for caffeine and Cancer of Lung
| Article | Year |
|---|---|
Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.
Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Cysteine Endopeptidases; | 2017 |
Caffeine Induces G0/G1 Cell Cycle Arrest and Inhibits Migration through Integrin αv, β3, and FAK/Akt/c-Myc Signaling Pathway.
Topics: Caffeine; Cell Line, Tumor; Cell Movement; Focal Adhesion Kinase 1; G1 Phase Cell Cycle Checkpoints; | 2021 |
Elevation of Anticancer Drug Toxicity by Caffeine in Spheroid Model of Human Lung Adenocarcinoma A549 Cells Mediated by Reduction in Claudin-2 and Nrf2 Expression.
Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Agents; Caffeine; Claudin-2; Doxorubicin; Humans; | 2022 |
Construction of DOX/APC co-loaded BiOI@CuS NPs for safe and highly effective CT imaging and chemo-photothermal therapy of lung cancer.
Topics: A549 Cells; Animals; Antibiotics, Antineoplastic; Aspirin; Bismuth; Caffeine; Cell Proliferation; Ce | 2019 |
Association between coffee drinking and telomere length in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Topics: Aged; Caffeine; Coffee; Colorectal Neoplasms; Cross-Sectional Studies; Female; Humans; Lung Neoplasm | 2020 |
Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation.
Topics: A549 Cells; Acetylation; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Caffeine; Cell Movem | 2020 |
Late recurrence of osteosarcoma: a report of two cases.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Child; Combine | 2014 |
Coffee, tea, caffeine intake, and the risk of cancer in the PLCO cohort.
Topics: Aged; Caffeine; Coffee; Colorectal Neoplasms; Female; Humans; Lung Neoplasms; Male; Middle Aged; Ova | 2015 |
Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Antineoplastic Agents; Ataxia Telangiectasia Mutated P | 2009 |
Caffeine-potentiated chemotherapy for metastatic osteosarcoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone | 2009 |
Haplotypes in the 5'-untranslated region of the CYP1A2 gene are inversely associated with lung cancer risk but do not correlate with caffeine metabolism.
Topics: 5' Untranslated Regions; Aged; Caffeine; Case-Control Studies; Chromatography, High Pressure Liquid; | 2013 |
Caffeine diminishes cytotoxic effects of paclitaxel on a human lung adenocarcinoma cell line.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Caffeine; Depression, Chemical; Dose-Response Rel | 2003 |
Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.
Topics: Adenocarcinoma; Androstadienes; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Protein | 2004 |
Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers.
Topics: Antineoplastic Combined Chemotherapy Protocols; Caffeine; Camptothecin; Carboplatin; Carcinoma, Non- | 2005 |
Caffeine suppresses metastasis in a transgenic mouse model: a prototype molecule for prophylaxis of metastasis.
Topics: Animals; Antigens, Polyomavirus Transforming; Biomarkers, Tumor; Caffeine; Central Nervous System St | 2004 |
Associations between black tea and coffee consumption and risk of lung cancer among current and former smokers.
Topics: Adult; Aged; Caffeine; Case-Control Studies; Coffee; Confidence Intervals; Drinking; Feeding Behavio | 2005 |
Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB and ERK1/2.
Topics: Adenocarcinoma; Blotting, Western; Caffeine; Cell Line, Tumor; Central Nervous System Stimulants; CR | 2006 |
Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells.
Topics: Adenocarcinoma; Alkaloids; Androstadienes; Apoptosis; Caffeine; Cell Cycle; Cell Line, Tumor; Chromo | 2006 |
Differential effect of selected methylxanthine derivatives on radiosensitization of lung carcinoma cells.
Topics: Apoptosis; Caffeine; Carcinoma, Large Cell; Cell Line, Tumor; Cell Survival; Flow Cytometry; Gamma R | 2006 |
p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Cell Proliferation; | 2006 |
Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine.
Topics: Adenocarcinoma; Adenoma; Analysis of Variance; Animals; Caffeine; Catechin; Cell Proliferation; Dise | 2006 |
Ca2+-dependent ATP release from A549 cells involves synergistic autocrine stimulation by coreleased uridine nucleotides.
Topics: Adenosine Triphosphate; Apyrase; Autocrine Communication; Caffeine; Calcium; Calcium Signaling; Calc | 2007 |
Timing of chemically induced neoplasia in mice revealed by the antineoplastic action of caffeine.
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; DNA Repair; Ethylnitrosourea; Female; Hydroxamic Acids; | 1980 |
Comparative inhibiting effects of methylxanthines on urethan-induced tumors, malformations, and presumed somatic mutations in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Caffeine; DNA Repair; Lung Neoplasms; M | 1983 |
The effect of caffeine on two-stage skin carcinogenesis and on complete systemic carcinogenesis.
Topics: Adenoma; Animals; Caffeine; Drug Interactions; Female; Lung Neoplasms; Mice; Mice, Inbred ICR; Neopl | 1981 |
Comparative carcinogenicities and mutagenicities of vinyl carbamate, ethyl carbamate, and ethyl N-hydroxycarbamate.
Topics: Adenoma; Animals; Caffeine; Carbamates; Ducks; Ear Neoplasms; Female; Hydroxamic Acids; In Vitro Tec | 1980 |
Inhibiting effects of antipain on urethane-induced lung neoplasia in mice.
Topics: Animals; Antipain; Caffeine; Female; Lung Neoplasms; Mice; Mice, Inbred ICR; Oligopeptides; Urethane | 1980 |
Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells.
Topics: Adenocarcinoma; Caffeine; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Radia | 1995 |
Greater enhancement of chemosensitivity by caffeine in high-p185neu-expressing human non-small-cell lung cancer cell lines.
Topics: Biomarkers, Tumor; Caffeine; Carcinoma, Non-Small-Cell Lung; Drug Synergism; ErbB Receptors; Gene Ex | 1994 |
P2u purinoceptor modulation of intracellular Ca2+ in a human lung adenocarcinoma cell line: down-regulation of Ca2+ influx by protein kinase C.
Topics: Adenocarcinoma; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Benzoquinone | 1996 |
In vitro enhancement of antitumor activity of a water-soluble duocarmycin derivative, KW-2189, by caffeine-mediated DNA-repair inhibition in human lung cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Caffeine; Carcinoma, Non-Small-Cell Lung; DNA Damage | 1997 |
Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation.
Topics: Animals; Caffeine; Cell Adhesion; Cell Division; Collagen; Laminin; Lung Neoplasms; Male; Melanins; | 1998 |
Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituent.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Caffeine; Carcinogens; Drug Screening Assays, Antitum | 1998 |
Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Calcium; Carcinoma, Small Cell; Cell Survival; Cyclic | 1998 |
Interaction between low dose-rate irradiation, mild hyperthermia and low-dose caffeine in a human lung cancer cell line.
Topics: Caffeine; Cell Cycle; Cell Survival; Combined Modality Therapy; Heat-Shock Proteins; HSP72 Heat-Shoc | 1999 |
Altered cell cycle response of drug-resistant lung carcinoma cells to doxorubicin.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, West | 2000 |
Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in Singapore.
Topics: Adenocarcinoma; Age Factors; Aged; Arylamine N-Acetyltransferase; Caffeine; Case-Control Studies; Ch | 2001 |
Effect of Caffeine, a xanthine derivative, in the inhibition of experimental lung metastasis induced by B16F10 melanoma cells.
Topics: Animals; Caffeine; Female; Hydroxyproline; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, | 2001 |
Caffeine induces TP53-independent G(1)-phase arrest and apoptosis in human lung tumor cells in a dose-dependent manner.
Topics: Adenocarcinoma; Apoptosis; Caffeine; CDC2 Protein Kinase; CDC2-CDC28 Kinases; cdc25 Phosphatases; Ce | 2002 |
Cyclic nucleotide phosphodiesterase activity of human normal and carcinomatous lung tissue.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Caffeine; Carcinoma, Squamous Cell; Cyclic AMP; Cyclic G | 1976 |
Inhibiting effect of caffeine on spontaneous and urethan-induced lung tumors in strain A mice.
Topics: Adenoma; Animals; Caffeine; DNA; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred A; Neoplasms, Experi | 1978 |
Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors.
Topics: Animals; Caffeine; Carmustine; Chlorpromazine; Drug Synergism; Drug Therapy, Combination; Female; Le | 1978 |
Diminution of tumorigenesis initiated by 4-nitroquinoline-1-oxide by post-treatment with caffeine in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; DNA Repair; Female; Lung Neoplasms; Male; Mice; Mice, I | 1976 |
Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds: effect of ascorbate, gallic acid, thiocyanate, and caffeine.
Topics: Adenoma; Amines; Animals; Ascorbic Acid; Caffeine; Dose-Response Relationship, Drug; Gallic Acid; Lu | 1975 |
Interaction of smoking, uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers.
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Humans; Lung Neopl | 1992 |
Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Caffeine; Carcinogens; Catechin; Deoxyguanosine; DNA; Female; | 1992 |
Usefulness of medium-term bioassay determining formations of pulmonary adenoma in NIH(GP) mice for finding anticarcinogenic agents from natural products.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Aflatoxin B1; Animals; Antineoplastic Agents, Phytogenic; | 1991 |
[Combination effect of caffeine and cisplatin on a cisplatin resistant human lung cancer cell line].
Topics: Adenocarcinoma; Caffeine; Cell Cycle; Cisplatin; Drug Resistance; Drug Synergism; Humans; Lung Neopl | 1990 |
Debrisoquine hydroxylation phenotype, acetylation phenotype, and ABO blood groups as genetic host factors of lung cancer risk.
Topics: ABO Blood-Group System; Acetylation; Acetyltransferases; Arylamine N-Acetyltransferase; Caffeine; Ca | 1988 |
Urinary excretion of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate.
Topics: Adult; Caffeine; Calcitonin; Calcium; Carcinoma, Bronchogenic; Circadian Rhythm; Cyclic AMP; Cyclic | 1972 |