Page last updated: 2024-10-24

caffeine and Cancer of Liver

caffeine has been researched along with Cancer of Liver in 47 studies

Research Excerpts

ExcerptRelevanceReference
"The authors carried out experiments on mice DBA/2 and BDF1 with leucosis L1210 and lung carcinoma of Lewis and found that psycotropic preparations tempidone and caffeine did not manifest antitumorous effect and toxicity after the used doses and scheme of treatment."7.66[Experiment to potentiate the effect of cyclophosphamide combined with tempidon and caffeine in leukemia L1210 and Lewis hepatic carcinoma]. ( Milushev, A; Stoichkov, I; Todorov, D, 1978)
" Clearance (Cl) was calculated using the equation of Cl = Kel x Vd (Kel = elimination rate constant, Vd = volume of distribution) and half-life was determined using pharmacokinetic analysis."5.31Caffeine clearance in patients with hepatocellular carcinoma after transcatheter oily chemoembolization treatment. ( Janchai, A; Mahachai, V; Tangkijvanich, P; Thong-Ngam, D; Thumvijit, L; Wittayalertpanya, S, 2002)
" We aimed to investigate the effects of caffeine and its analog CGS 15943 on hepatocellular carcinoma (HCC) and pancreatic cancer adenocarcinoma (PDAC)."3.80Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. ( Edling, CE; Falasca, M; Ghonaim, R; Maffucci, T; Selvaggi, F, 2014)
"Sorafenib is a multi-kinase inhibitor applicable to hepatocellular carcinoma (HCC), but its limited therapeutic effects are a major problem to be solved."3.78Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling. ( Aoyagi, Y; Fujimaki, S; Kubota, M; Matsuda, Y; Ohkoshi, S; Sanpei, A; Takamura, M; Wakai, T; Yamagiwa, S; Yano, M, 2012)
" A total of 230 males were initially injected with diethylnitrosamine (200 mg/kg body weight, ip) or saline as controls and 2 wk later were fed on diet or drinking water supplemented as follows for 6 wk: 5% regular instant coffee; 5% decaffeinated instant coffee; freshly brewed coffee, 8 g in 140 ml water; 0."3.69Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. ( Hasegawa, R; Imaida, K; Ito, N; Ogiso, T; Shirai, T, 1995)
"The authors carried out experiments on mice DBA/2 and BDF1 with leucosis L1210 and lung carcinoma of Lewis and found that psycotropic preparations tempidone and caffeine did not manifest antitumorous effect and toxicity after the used doses and scheme of treatment."3.66[Experiment to potentiate the effect of cyclophosphamide combined with tempidon and caffeine in leukemia L1210 and Lewis hepatic carcinoma]. ( Milushev, A; Stoichkov, I; Todorov, D, 1978)
" The alkaloids caffeine and trigonelline, as well as the polyphenol chlorogenic acid, are some of the most important bioactive organic compounds of these beverages, displaying high levels in both espresso and common brews and/or increased bioavailability after consumption."2.61Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis. ( Barbisan, LF; Chaves, MAG; Cogliati, B; Moreno, FS; Rocha, AB; Romualdo, GR; Vinken, M, 2019)
" We calculated relative risks (RRs) of HCC according to caffeinated and decaffeinated coffee consumption using a random-effects dose-response meta-analysis."2.55Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose-response meta-analysis. ( Buchanan, R; Fallowfield, JA; Hayes, PC; Kennedy, OJ; Parkes, J; Roderick, P, 2017)
"Obesity, non-alcoholic fatty liver and steatohepatitis as well as diabetes mellitus together also form a significant risk for HCC, due to the gradually increasing number of patients."2.46[Role of environmental factors in the etiology of hepatocellular carcinoma]. ( Tornai, I, 2010)
" It is currently unknown whether these protective effects are related to caffeine (CAF), or to its combination with other common and/or highly bioavailable coffee compounds, such as trigonelline (TRI) and chlorogenic acid (CGA)."1.56The combination of coffee compounds attenuates early fibrosis-associated hepatocarcinogenesis in mice: involvement of miRNA profile modulation. ( Barbisan, LF; Cogliati, B; da Silva, TC; Evangelista, AF; Moreno, FS; Prata, GB; Reis, RM; Romualdo, GR; Vinken, M, 2020)
"22,652 incident cancers occurred during 10."1.51Association between tea consumption and risk of cancer: a prospective cohort study of 0.5 million Chinese adults. ( Bian, Z; Chen, F; Chen, J; Chen, Y; Chen, Z; Guo, Y; Li, L; Li, X; Lv, J; Qiu, Z; Shen, Z; Wei, Y; Yang, L; Yu, C; Zhang, H, 2019)
"Metabolic syndrome is one of the most important health issues worldwide."1.46Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice. ( Baba, H; Morimoto, Y; Ogawa, H; Takahashi, T; Tsunematsu, T; Tsuneyama, K; Uehara, H; Watanabe, S, 2017)
"Caffeine has chemopreventive properties, but whether caffeine is responsible for the coffee-HCC association is not well studied."1.42Coffee Consumption and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Sex: The Liver Cancer Pooling Project. ( Alavanja, MC; Beane-Freeman, LE; Boggs, DA; Buring, JE; Campbell, PT; Chan, AT; Chong, DQ; Freedman, ND; Fuchs, CS; Gapstur, SM; Gaziano, JM; Giovannucci, EL; Graubard, BI; Hollenbeck, AR; King, LY; Koshiol, J; Lai, GY; Lee, IM; Linet, MS; McGlynn, KA; Palmer, JR; Petrick, JL; Poynter, JN; Purdue, MP; Robien, K; Sahasrabuddhe, VV; Schairer, C; Sesso, HD; Sigurdson, AJ; Wactawski-Wende, J; Zeleniuch-Jacquotte, A, 2015)
" Univariate and multivariate logistic regressions adjusting for age, gender, cigarette smoking, alcohol use, tea consumption and physical activity were conducted with dose-response analysis."1.37Moderate coffee consumption reduces the risk of hepatocellular carcinoma in hepatitis B chronic carriers: a case-control study. ( Chan, HL; Ho, SC; Leung, WW; Mok, TS; Wong, V; Yeo, W, 2011)
"Caffeine has been reported to prevent hepatocarcinogenesis."1.35Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway. ( Matsumoto, K; Murawaki, Y; Nagahara, T; Okano, J, 2008)
" Clearance (Cl) was calculated using the equation of Cl = Kel x Vd (Kel = elimination rate constant, Vd = volume of distribution) and half-life was determined using pharmacokinetic analysis."1.31Caffeine clearance in patients with hepatocellular carcinoma after transcatheter oily chemoembolization treatment. ( Janchai, A; Mahachai, V; Tangkijvanich, P; Thong-Ngam, D; Thumvijit, L; Wittayalertpanya, S, 2002)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199010 (21.28)18.7374
1990's5 (10.64)18.2507
2000's9 (19.15)29.6817
2010's22 (46.81)24.3611
2020's1 (2.13)2.80

Authors

AuthorsStudies
Wang, Z1
Gu, C1
Wang, X2
Lang, Y1
Wu, Y2
Wu, X1
Zhu, X1
Wang, K1
Yang, H2
Romualdo, GR2
Prata, GB1
da Silva, TC1
Evangelista, AF1
Reis, RM1
Vinken, M2
Moreno, FS2
Cogliati, B2
Barbisan, LF2
Watanabe, S1
Takahashi, T1
Ogawa, H1
Uehara, H1
Tsunematsu, T1
Baba, H1
Morimoto, Y1
Tsuneyama, K1
Kennedy, OJ1
Roderick, P1
Buchanan, R1
Fallowfield, JA1
Hayes, PC1
Parkes, J1
Oda, Y1
Hidaka, M1
Suzuki, A1
Li, J1
Cui, L2
Ren, Y1
Niu, L1
Huang, Y1
Inoue, M1
Tsugane, S1
Li, X2
Yu, C1
Guo, Y1
Bian, Z1
Shen, Z1
Yang, L1
Chen, Y1
Wei, Y1
Zhang, H1
Qiu, Z1
Chen, J1
Chen, F1
Chen, Z1
Lv, J1
Li, L1
Rocha, AB1
Chaves, MAG1
Katayama, M1
Donai, K1
Sakakibara, H1
Ohtomo, Y1
Miyagawa, M1
Kuroda, K1
Kodama, H1
Suzuki, K1
Kasai, N1
Nishimori, K1
Uchida, T1
Watanabe, K1
Aso, H1
Isogai, E1
Sone, H1
Fukuda, T1
Sinha, RA1
Farah, BL1
Singh, BK1
Siddique, MM1
Li, Y1
Ilkayeva, OR1
Gooding, J1
Ching, J1
Zhou, J1
Martinez, L1
Xie, S1
Bay, BH1
Summers, SA1
Newgard, CB1
Yen, PM1
Saab, S1
Mallam, D1
Cox, GA1
Tong, MJ1
Edling, CE1
Selvaggi, F1
Ghonaim, R1
Maffucci, T1
Falasca, M1
Bamia, C1
Lagiou, P1
Jenab, M1
Trichopoulou, A1
Fedirko, V1
Aleksandrova, K1
Pischon, T1
Overvad, K1
Olsen, A1
Tjønneland, A1
Boutron-Ruault, MC1
Fagherazzi, G1
Racine, A1
Kuhn, T1
Boeing, H1
Floegel, A1
Benetou, V1
Palli, D1
Grioni, S1
Panico, S1
Tumino, R1
Vineis, P1
Bueno-de-Mesquita, HB1
Dik, VK1
Bhoo-Pathy, N1
Uiterwaal, CS1
Weiderpass, E1
Lund, E1
Quirós, JR1
Zamora-Ros, R1
Molina-Montes, E1
Chirlaque, MD1
Ardanaz, E1
Dorronsoro, M1
Lindkvist, B1
Wallström, P1
Nilsson, LM1
Sund, M1
Khaw, KT1
Wareham, N1
Bradbury, KE1
Travis, RC1
Ferrari, P1
Duarte-Salles, T1
Stepien, M1
Gunter, M1
Murphy, N1
Riboli, E1
Trichopoulos, D1
Dong, S1
Kong, J2
Shen, Q1
Kong, F1
Sun, W1
Zheng, L1
Petrick, JL1
Freedman, ND1
Graubard, BI1
Sahasrabuddhe, VV1
Lai, GY1
Alavanja, MC1
Beane-Freeman, LE1
Boggs, DA1
Buring, JE1
Chan, AT1
Chong, DQ1
Fuchs, CS1
Gapstur, SM1
Gaziano, JM1
Giovannucci, EL1
Hollenbeck, AR1
King, LY1
Koshiol, J1
Lee, IM1
Linet, MS1
Palmer, JR1
Poynter, JN1
Purdue, MP1
Robien, K1
Schairer, C1
Sesso, HD1
Sigurdson, AJ1
Zeleniuch-Jacquotte, A1
Wactawski-Wende, J1
Campbell, PT1
McGlynn, KA1
Stępnik, M1
Spryszyńska, S1
Smok-Pieniążek, A1
Ferlińska, M1
Roszak, J1
Nocuń, M1
Salomone, F1
Galvano, F1
Li Volti, G1
Tao, KS1
Wang, W1
Wang, L1
Cao, DY1
Li, YQ1
Wu, SX1
Dou, KF1
Mann, CD1
Neal, CP1
Garcea, G1
Manson, MM1
Dennison, AR1
Berry, DP1
Gressner, OA1
Wu, JF1
Zeng, GL1
Shen, W1
Yang, M1
Wang, F1
Tian, L1
Hu, WY1
Li, XP1
Ren, H1
Tang, KF1
Muriel, P1
Arauz, J1
Tornai, I1
Leung, WW1
Ho, SC1
Chan, HL1
Wong, V1
Yeo, W1
Mok, TS1
Fujimaki, S1
Matsuda, Y1
Wakai, T1
Sanpei, A1
Kubota, M1
Takamura, M1
Yamagiwa, S1
Yano, M1
Ohkoshi, S1
Aoyagi, Y1
Fujise, Y1
Okano, J2
Nagahara, T2
Abe, R1
Imamoto, R1
Murawaki, Y2
Thong-Ngam, D2
Thumvijit, L1
Tangkijvanich, P2
Janchai, A1
Mahachai, V2
Wittayalertpanya, S2
BREGADZE, IL1
KUZNETSOV, IuV1
Higdon, JV1
Frei, B1
Cadden, IS1
Partovi, N1
Yoshida, EM1
Matsumoto, K1
Gurkalo, VK1
Zabezhinski, MA1
McAleer, WJ1
Markus, HZ1
Bailey, FJ1
Herman, AC1
Harder, BJ1
Wampler, DE1
Miller, WJ1
Keller, PM1
Buynak, EB1
Hilleman, MR1
Baker, AL1
Kotake, AN1
Schoeller, DA1
Macklin, AW1
Szot, RJ1
Johansson, SL1
Hasegawa, R1
Ogiso, T1
Imaida, K1
Shirai, T1
Ito, N1
Kusonsolboon, T1
Silins, I1
Finnberg, N1
Ståhl, A1
Högberg, J1
Stenius, U1
Stoichkov, I1
Milushev, A1
Todorov, D1
McDonagh, JE1
Nathan, VV1
Bonavia, IC1
Moyle, GR1
Tanner, AR1
Jansen, PL1
Chamuleau, RA1
van Leeuwen, DJ1
Schipper, HG1
Busemann-Sokole, E1
van der Heyde, MN1
Ganapathi, MK1
Mackiewicz, A1
Samols, D1
Brabenec, A1
Kushner, I1
Schultz, D1
Hu, SI1
Varagnolo, M1
Plebani, M1
Mussap, M1
Nemetz, L1
Paleari, CD1
Burlina, A1
Siden, EJ1
Gifford, A1
Baltimore, D1
Cappadona, C1
Valguarnera, G1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Neuroplastic Alterations of the Motor Cortex by Caffeine: Differences Between Caffeine and Non-caffeine Users and Influence of Vigilance During Stimulation[NCT04011670]30 participants (Actual)Interventional2019-07-15Completed
Effect of Coffee and Tea Consumption on Adolescent Weight Control - a Randomized Clinical Trial[NCT05181176]63 participants (Anticipated)Interventional2021-01-01Recruiting
Cortical Excitability Changes on the Sensorimotor Cortex Induced by Caffeine Consumption: A TMS Study[NCT03720665]30 participants (Actual)Interventional2018-10-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

12 reviews available for caffeine and Cancer of Liver

ArticleYear
Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose-response meta-analysis.
    BMJ open, 2017, 05-09, Volume: 7, Issue:5

    Topics: Caffeine; Carcinoma, Hepatocellular; Coffee; Dose-Response Relationship, Drug; Humans; Liver Neoplas

2017
Coffee Drinking and Reduced Risk of Liver Cancer: Update on Epidemiological Findings and Potential Mechanisms.
    Current nutrition reports, 2019, Volume: 8, Issue:3

    Topics: Antioxidants; Caffeine; Cardiovascular Diseases; Chlorogenic Acid; Coffee; Diabetes Mellitus; Drinki

2019
Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis.
    Food research international (Ottawa, Ont.), 2019, Volume: 123

    Topics: Alkaloids; Caffeine; Carcinogenesis; Chlorogenic Acid; Coffea; Coffee; Gastrointestinal Neoplasms; G

2019
Impact of coffee on liver diseases: a systematic review.
    Liver international : official journal of the International Association for the Study of the Liver, 2014, Volume: 34, Issue:4

    Topics: Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Caffeine; Carcinoma, Hepatocell

2014
Molecular Bases Underlying the Hepatoprotective Effects of Coffee.
    Nutrients, 2017, Jan-23, Volume: 9, Issue:1

    Topics: Animals; Caffeine; Chlorogenic Acid; Coffee; Disease Models, Animal; Fatty Liver; Humans; Lipid Meta

2017
Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2009, Volume: 18, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Brassicaceae; Caffeine; Capsaicin; Carcinoma, Hepatocell

2009
Less Smad2 is good for you! A scientific update on coffee's liver benefits.
    Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:3

    Topics: Acetylgalactosamine; Animals; Caffeine; Carcinoma, Hepatocellular; Collagen Type I; Connective Tissu

2009
Coffee and liver diseases.
    Fitoterapia, 2010, Volume: 81, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Caffeine; Carcinoma, Hepatocellular; Coffee; Diterpenes;

2010
[Role of environmental factors in the etiology of hepatocellular carcinoma].
    Orvosi hetilap, 2010, Jul-11, Volume: 151, Issue:28

    Topics: Aflatoxins; Alcohol Drinking; Antioxidants; Caffeine; Carcinoma, Hepatocellular; Coffee; Contracepti

2010
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Coffee and health: a review of recent human research.
    Critical reviews in food science and nutrition, 2006, Volume: 46, Issue:2

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee

2006
Review article: possible beneficial effects of coffee on liver disease and function.
    Alimentary pharmacology & therapeutics, 2007, Jul-01, Volume: 26, Issue:1

    Topics: Caffeine; Carcinoma, Hepatocellular; Coffee; Humans; Liver Cirrhosis; Liver Neoplasms; Phosphodieste

2007
Clinical utility of breath tests for the assessment of hepatic function.
    Seminars in liver disease, 1983, Volume: 3, Issue:4

    Topics: Aminopyrine; Breath Tests; Caffeine; Chemical and Drug Induced Liver Injury; Chronic Disease; Cytoch

1983

Trials

1 trial available for caffeine and Cancer of Liver

ArticleYear
Caffeine clearance study in hepatocellular carcinoma.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1999, Volume: 82, Issue:3

    Topics: Adult; Aged; Caffeine; Carcinoma, Hepatocellular; Female; Humans; Liver; Liver Cirrhosis; Liver Func

1999

Other Studies

34 other studies available for caffeine and Cancer of Liver

ArticleYear
Caffeine enhances the anti-tumor effect of 5-fluorouracil via increasing the production of reactive oxygen species in hepatocellular carcinoma.
    Medical oncology (Northwood, London, England), 2019, Oct-29, Volume: 36, Issue:12

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis;

2019
The combination of coffee compounds attenuates early fibrosis-associated hepatocarcinogenesis in mice: involvement of miRNA profile modulation.
    The Journal of nutritional biochemistry, 2020, Volume: 85

    Topics: Alkaloids; Animals; Anticarcinogenic Agents; Caffeine; Carcinoma, Hepatocellular; Cell Line, Tumor;

2020
Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice.
    Metabolic syndrome and related disorders, 2017, Volume: 15, Issue:4

    Topics: Aging; Animals; Caffeine; Coffee; Diabetes Mellitus, Type 2; Hyperlipidemias; Insulin-Secreting Cell

2017
Caffeine Has a Synergistic Anticancer Effect with Cisplatin via Inhibiting Fanconi Anemia Group D2 Protein Monoubiquitination in Hepatocellular Carcinoma Cells.
    Biological & pharmaceutical bulletin, 2017, Nov-01, Volume: 40, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Caffeine; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferatio

2017
Synergistic cytotoxicity and mechanism of caffeine and lysozyme on hepatoma cell line HepG2.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2018, Mar-15, Volume: 193

    Topics: Apoptosis; Caffeine; Carcinoma, Hepatocellular; Cell Proliferation; Drug Synergism; Hep G2 Cells; Hu

2018
Association between tea consumption and risk of cancer: a prospective cohort study of 0.5 million Chinese adults.
    European journal of epidemiology, 2019, Volume: 34, Issue:8

    Topics: Adult; Aged; Alcohol Drinking; Asian People; Breast Neoplasms; Caffeine; China; Colorectal Neoplasms

2019
Coffee consumption delays the hepatitis and suppresses the inflammation related gene expression in the Long-Evans Cinnamon rat.
    Clinical nutrition (Edinburgh, Scotland), 2014, Volume: 33, Issue:2

    Topics: Adenosine Triphosphatases; Alanine Transaminase; Animals; Caffeine; Cation Transport Proteins; Cinna

2014
Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.
    Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:4

    Topics: Animals; Autophagy; Caffeine; Cell Line, Tumor; Diet, High-Fat; Down-Regulation; Fatty Liver; Hep G2

2014
Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway.
    Cancer biology & therapy, 2014, Volume: 15, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Caffeine; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal;

2014
Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: multicentre, prospective cohort study.
    International journal of cancer, 2015, Apr-15, Volume: 136, Issue:8

    Topics: Beverages; Caffeine; Carcinoma, Hepatocellular; Case-Control Studies; Coffee; Europe; Female; Humans

2015
Low Concentration of Caffeine Inhibits the Progression of the Hepatocellular Carcinoma via Akt Signaling Pathway.
    Anti-cancer agents in medicinal chemistry, 2015, Volume: 15, Issue:4

    Topics: Animals; Antineoplastic Agents; Caffeine; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor

2015
Coffee Consumption and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Sex: The Liver Cancer Pooling Project.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015, Volume: 24, Issue:9

    Topics: Aged; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Caffeine; Carcinoma, Hepatocellular; Cholangioc

2015
The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.
    Environmental toxicology and pharmacology, 2015, Volume: 40, Issue:3

    Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Benzo(a)pyrene; Caffeine; Cell Survival; Chromone

2015
The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver.
    Medical hypotheses, 2008, Volume: 71, Issue:5

    Topics: Animals; Anticarcinogenic Agents; Antioxidants; Caffeine; Chlorogenic Acid; Coffee; Diterpenes; Huma

2008
[Up-regulation of major histocompatibility complex class I-related molecules A (MICA) induced by 5-aza-2'-deoxycytidine].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2009, Volume: 17, Issue:9

    Topics: Ataxia Telangiectasia Mutated Proteins; Azacitidine; Caffeine; Carcinoma, Hepatocellular; Cell Cycle

2009
Moderate coffee consumption reduces the risk of hepatocellular carcinoma in hepatitis B chronic carriers: a case-control study.
    Journal of epidemiology and community health, 2011, Volume: 65, Issue:6

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Case-Control Studies; Coffee; Dose-Response Relationship

2011
Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling.
    Cancer letters, 2012, Jun-01, Volume: 319, Issue:1

    Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Benzenesulfonates; Caffeine; Carcinom

2012
Preventive effect of caffeine and curcumin on hepato-carcinogenesis in diethylnitrosamine-induced rats.
    International journal of oncology, 2012, Volume: 40, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Caffeine; Carcinoma, Hepatocellular; Curcumin; Diethylnitrosamine;

2012
Caffeine clearance in patients with hepatocellular carcinoma after transcatheter oily chemoembolization treatment.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2002, Volume: 85, Issue:12

    Topics: Adult; Aged; Analysis of Variance; Caffeine; Carcinoma, Hepatocellular; Chemoembolization, Therapeut

2002
[COMPLICATIONS DURING BROMSULPHALEIN TESTS].
    Klinicheskaia meditsina, 1964, Volume: 42

    Topics: Caffeine; Calcium; Diphenhydramine; Echinococcosis; Echinococcosis, Hepatic; Hemangiosarcoma; Liver

1964
Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway.
    Basic & clinical pharmacology & toxicology, 2008, Volume: 102, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Caffeine; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor;

2008
On participation of the autonomic nervous system in the mechanisms of chemical carcinogenesis.
    Neoplasma, 1982, Volume: 29, Issue:3

    Topics: Acetylcholinesterase; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine;

1982
Production of purified hepatitis B surface antigen from Alexander hepatoma cells grown in artificial capillary units.
    Journal of virological methods, 1983, Volume: 7, Issue:5-6

    Topics: Caffeine; Carcinoma, Hepatocellular; Cell Line; Chromatography, Affinity; Culture Media; Culture Tec

1983
Eighteen month oral study of aspirin, phenacetin and caffeine, in C57Bl/6 mice.
    Drug and chemical toxicology, 1980, Volume: 3, Issue:2

    Topics: Animals; Aspirin; Caffeine; Carcinogens; Diet; Female; Kidney; Liver; Liver Neoplasms; Male; Mice; M

1980
Carcinogenicity of analgesics: long-term treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen).
    International journal of cancer, 1981, Volume: 27, Issue:4

    Topics: Acetaminophen; Adenocarcinoma; Analgesics; Animals; Antipyrine; Caffeine; Carcinogens; Carcinoma, Sq

1981
Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:1

    Topics: Administration, Oral; Animals; Biological Assay; Body Weight; Caffeine; Coffee; Diethylnitrosamine;

1995
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
    Carcinogenesis, 2001, Volume: 22, Issue:12

    Topics: Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Carcin

2001
[Experiment to potentiate the effect of cyclophosphamide combined with tempidon and caffeine in leukemia L1210 and Lewis hepatic carcinoma].
    Eksperimentalna meditsina i morfologiia, 1978, Volume: 17, Issue:1

    Topics: Animals; Caffeine; Carcinoma; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation, P

1978
Caffeine clearance by enzyme multiplied immunoassay technique: a simple, inexpensive, and useful indicator of liver function.
    Gut, 1991, Volume: 32, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Caffeine; Humans; Immunoenzyme Techniques; Liver Cirrhosis; Liver Di

1991
Liver regeneration and restoration of liver function after partial hepatectomy in patients with liver tumors.
    Scandinavian journal of gastroenterology, 1990, Volume: 25, Issue:2

    Topics: Adult; Aged; Caffeine; Carcinoma, Hepatocellular; Female; Galactose; Hepatectomy; Humans; Liver; Liv

1990
Induction of C-reactive protein by cytokines in human hepatoma cell lines is potentiated by caffeine.
    The Biochemical journal, 1990, Jul-01, Volume: 269, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; C-Reactive Protein; Caffeine; Calcimycin; Calcium; Carcinoma

1990
Caffeine as indicator of metabolic functions of microsomal liver enzymes.
    Clinica chimica acta; international journal of clinical chemistry, 1989, Jul-31, Volume: 183, Issue:1

    Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Female; Half-Life;

1989
Cyclic AMP induces terminal deoxynucleotidyl transferase in immature B cell leukemia lines.
    Journal of immunology (Baltimore, Md. : 1950), 1985, Volume: 135, Issue:2

    Topics: Animals; B-Lymphocytes; Bucladesine; Caffeine; Cell Line; Cyclic AMP; DNA Nucleotidylexotransferase;

1985
[Distribution of caffeine in animals with experimental transplantable tumors. Tests with tritium-labeled caffeine for the study of the sensitizing properties].
    Bollettino della Societa italiana di biologia sperimentale, 1971, May-30, Volume: 47, Issue:10

    Topics: Animals; Ascitic Fluid; Caffeine; Carcinoma, Hepatocellular; Kidney; Liver; Liver Neoplasms; Mice; N

1971