caffeine has been researched along with Cancer of Liver in 47 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors carried out experiments on mice DBA/2 and BDF1 with leucosis L1210 and lung carcinoma of Lewis and found that psycotropic preparations tempidone and caffeine did not manifest antitumorous effect and toxicity after the used doses and scheme of treatment." | 7.66 | [Experiment to potentiate the effect of cyclophosphamide combined with tempidon and caffeine in leukemia L1210 and Lewis hepatic carcinoma]. ( Milushev, A; Stoichkov, I; Todorov, D, 1978) |
| " Clearance (Cl) was calculated using the equation of Cl = Kel x Vd (Kel = elimination rate constant, Vd = volume of distribution) and half-life was determined using pharmacokinetic analysis." | 5.31 | Caffeine clearance in patients with hepatocellular carcinoma after transcatheter oily chemoembolization treatment. ( Janchai, A; Mahachai, V; Tangkijvanich, P; Thong-Ngam, D; Thumvijit, L; Wittayalertpanya, S, 2002) |
| " We aimed to investigate the effects of caffeine and its analog CGS 15943 on hepatocellular carcinoma (HCC) and pancreatic cancer adenocarcinoma (PDAC)." | 3.80 | Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. ( Edling, CE; Falasca, M; Ghonaim, R; Maffucci, T; Selvaggi, F, 2014) |
| "Sorafenib is a multi-kinase inhibitor applicable to hepatocellular carcinoma (HCC), but its limited therapeutic effects are a major problem to be solved." | 3.78 | Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling. ( Aoyagi, Y; Fujimaki, S; Kubota, M; Matsuda, Y; Ohkoshi, S; Sanpei, A; Takamura, M; Wakai, T; Yamagiwa, S; Yano, M, 2012) |
| " A total of 230 males were initially injected with diethylnitrosamine (200 mg/kg body weight, ip) or saline as controls and 2 wk later were fed on diet or drinking water supplemented as follows for 6 wk: 5% regular instant coffee; 5% decaffeinated instant coffee; freshly brewed coffee, 8 g in 140 ml water; 0." | 3.69 | Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. ( Hasegawa, R; Imaida, K; Ito, N; Ogiso, T; Shirai, T, 1995) |
| "The authors carried out experiments on mice DBA/2 and BDF1 with leucosis L1210 and lung carcinoma of Lewis and found that psycotropic preparations tempidone and caffeine did not manifest antitumorous effect and toxicity after the used doses and scheme of treatment." | 3.66 | [Experiment to potentiate the effect of cyclophosphamide combined with tempidon and caffeine in leukemia L1210 and Lewis hepatic carcinoma]. ( Milushev, A; Stoichkov, I; Todorov, D, 1978) |
| " The alkaloids caffeine and trigonelline, as well as the polyphenol chlorogenic acid, are some of the most important bioactive organic compounds of these beverages, displaying high levels in both espresso and common brews and/or increased bioavailability after consumption." | 2.61 | Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis. ( Barbisan, LF; Chaves, MAG; Cogliati, B; Moreno, FS; Rocha, AB; Romualdo, GR; Vinken, M, 2019) |
| " We calculated relative risks (RRs) of HCC according to caffeinated and decaffeinated coffee consumption using a random-effects dose-response meta-analysis." | 2.55 | Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose-response meta-analysis. ( Buchanan, R; Fallowfield, JA; Hayes, PC; Kennedy, OJ; Parkes, J; Roderick, P, 2017) |
| "Obesity, non-alcoholic fatty liver and steatohepatitis as well as diabetes mellitus together also form a significant risk for HCC, due to the gradually increasing number of patients." | 2.46 | [Role of environmental factors in the etiology of hepatocellular carcinoma]. ( Tornai, I, 2010) |
| " It is currently unknown whether these protective effects are related to caffeine (CAF), or to its combination with other common and/or highly bioavailable coffee compounds, such as trigonelline (TRI) and chlorogenic acid (CGA)." | 1.56 | The combination of coffee compounds attenuates early fibrosis-associated hepatocarcinogenesis in mice: involvement of miRNA profile modulation. ( Barbisan, LF; Cogliati, B; da Silva, TC; Evangelista, AF; Moreno, FS; Prata, GB; Reis, RM; Romualdo, GR; Vinken, M, 2020) |
| "22,652 incident cancers occurred during 10." | 1.51 | Association between tea consumption and risk of cancer: a prospective cohort study of 0.5 million Chinese adults. ( Bian, Z; Chen, F; Chen, J; Chen, Y; Chen, Z; Guo, Y; Li, L; Li, X; Lv, J; Qiu, Z; Shen, Z; Wei, Y; Yang, L; Yu, C; Zhang, H, 2019) |
| "Metabolic syndrome is one of the most important health issues worldwide." | 1.46 | Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice. ( Baba, H; Morimoto, Y; Ogawa, H; Takahashi, T; Tsunematsu, T; Tsuneyama, K; Uehara, H; Watanabe, S, 2017) |
| "Caffeine has chemopreventive properties, but whether caffeine is responsible for the coffee-HCC association is not well studied." | 1.42 | Coffee Consumption and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Sex: The Liver Cancer Pooling Project. ( Alavanja, MC; Beane-Freeman, LE; Boggs, DA; Buring, JE; Campbell, PT; Chan, AT; Chong, DQ; Freedman, ND; Fuchs, CS; Gapstur, SM; Gaziano, JM; Giovannucci, EL; Graubard, BI; Hollenbeck, AR; King, LY; Koshiol, J; Lai, GY; Lee, IM; Linet, MS; McGlynn, KA; Palmer, JR; Petrick, JL; Poynter, JN; Purdue, MP; Robien, K; Sahasrabuddhe, VV; Schairer, C; Sesso, HD; Sigurdson, AJ; Wactawski-Wende, J; Zeleniuch-Jacquotte, A, 2015) |
| " Univariate and multivariate logistic regressions adjusting for age, gender, cigarette smoking, alcohol use, tea consumption and physical activity were conducted with dose-response analysis." | 1.37 | Moderate coffee consumption reduces the risk of hepatocellular carcinoma in hepatitis B chronic carriers: a case-control study. ( Chan, HL; Ho, SC; Leung, WW; Mok, TS; Wong, V; Yeo, W, 2011) |
| "Caffeine has been reported to prevent hepatocarcinogenesis." | 1.35 | Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway. ( Matsumoto, K; Murawaki, Y; Nagahara, T; Okano, J, 2008) |
| " Clearance (Cl) was calculated using the equation of Cl = Kel x Vd (Kel = elimination rate constant, Vd = volume of distribution) and half-life was determined using pharmacokinetic analysis." | 1.31 | Caffeine clearance in patients with hepatocellular carcinoma after transcatheter oily chemoembolization treatment. ( Janchai, A; Mahachai, V; Tangkijvanich, P; Thong-Ngam, D; Thumvijit, L; Wittayalertpanya, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (21.28) | 18.7374 |
| 1990's | 5 (10.64) | 18.2507 |
| 2000's | 9 (19.15) | 29.6817 |
| 2010's | 22 (46.81) | 24.3611 |
| 2020's | 1 (2.13) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Z | 1 |
| Gu, C | 1 |
| Wang, X | 2 |
| Lang, Y | 1 |
| Wu, Y | 2 |
| Wu, X | 1 |
| Zhu, X | 1 |
| Wang, K | 1 |
| Yang, H | 2 |
| Romualdo, GR | 2 |
| Prata, GB | 1 |
| da Silva, TC | 1 |
| Evangelista, AF | 1 |
| Reis, RM | 1 |
| Vinken, M | 2 |
| Moreno, FS | 2 |
| Cogliati, B | 2 |
| Barbisan, LF | 2 |
| Watanabe, S | 1 |
| Takahashi, T | 1 |
| Ogawa, H | 1 |
| Uehara, H | 1 |
| Tsunematsu, T | 1 |
| Baba, H | 1 |
| Morimoto, Y | 1 |
| Tsuneyama, K | 1 |
| Kennedy, OJ | 1 |
| Roderick, P | 1 |
| Buchanan, R | 1 |
| Fallowfield, JA | 1 |
| Hayes, PC | 1 |
| Parkes, J | 1 |
| Oda, Y | 1 |
| Hidaka, M | 1 |
| Suzuki, A | 1 |
| Li, J | 1 |
| Cui, L | 2 |
| Ren, Y | 1 |
| Niu, L | 1 |
| Huang, Y | 1 |
| Inoue, M | 1 |
| Tsugane, S | 1 |
| Li, X | 2 |
| Yu, C | 1 |
| Guo, Y | 1 |
| Bian, Z | 1 |
| Shen, Z | 1 |
| Yang, L | 1 |
| Chen, Y | 1 |
| Wei, Y | 1 |
| Zhang, H | 1 |
| Qiu, Z | 1 |
| Chen, J | 1 |
| Chen, F | 1 |
| Chen, Z | 1 |
| Lv, J | 1 |
| Li, L | 1 |
| Rocha, AB | 1 |
| Chaves, MAG | 1 |
| Katayama, M | 1 |
| Donai, K | 1 |
| Sakakibara, H | 1 |
| Ohtomo, Y | 1 |
| Miyagawa, M | 1 |
| Kuroda, K | 1 |
| Kodama, H | 1 |
| Suzuki, K | 1 |
| Kasai, N | 1 |
| Nishimori, K | 1 |
| Uchida, T | 1 |
| Watanabe, K | 1 |
| Aso, H | 1 |
| Isogai, E | 1 |
| Sone, H | 1 |
| Fukuda, T | 1 |
| Sinha, RA | 1 |
| Farah, BL | 1 |
| Singh, BK | 1 |
| Siddique, MM | 1 |
| Li, Y | 1 |
| Ilkayeva, OR | 1 |
| Gooding, J | 1 |
| Ching, J | 1 |
| Zhou, J | 1 |
| Martinez, L | 1 |
| Xie, S | 1 |
| Bay, BH | 1 |
| Summers, SA | 1 |
| Newgard, CB | 1 |
| Yen, PM | 1 |
| Saab, S | 1 |
| Mallam, D | 1 |
| Cox, GA | 1 |
| Tong, MJ | 1 |
| Edling, CE | 1 |
| Selvaggi, F | 1 |
| Ghonaim, R | 1 |
| Maffucci, T | 1 |
| Falasca, M | 1 |
| Bamia, C | 1 |
| Lagiou, P | 1 |
| Jenab, M | 1 |
| Trichopoulou, A | 1 |
| Fedirko, V | 1 |
| Aleksandrova, K | 1 |
| Pischon, T | 1 |
| Overvad, K | 1 |
| Olsen, A | 1 |
| Tjønneland, A | 1 |
| Boutron-Ruault, MC | 1 |
| Fagherazzi, G | 1 |
| Racine, A | 1 |
| Kuhn, T | 1 |
| Boeing, H | 1 |
| Floegel, A | 1 |
| Benetou, V | 1 |
| Palli, D | 1 |
| Grioni, S | 1 |
| Panico, S | 1 |
| Tumino, R | 1 |
| Vineis, P | 1 |
| Bueno-de-Mesquita, HB | 1 |
| Dik, VK | 1 |
| Bhoo-Pathy, N | 1 |
| Uiterwaal, CS | 1 |
| Weiderpass, E | 1 |
| Lund, E | 1 |
| Quirós, JR | 1 |
| Zamora-Ros, R | 1 |
| Molina-Montes, E | 1 |
| Chirlaque, MD | 1 |
| Ardanaz, E | 1 |
| Dorronsoro, M | 1 |
| Lindkvist, B | 1 |
| Wallström, P | 1 |
| Nilsson, LM | 1 |
| Sund, M | 1 |
| Khaw, KT | 1 |
| Wareham, N | 1 |
| Bradbury, KE | 1 |
| Travis, RC | 1 |
| Ferrari, P | 1 |
| Duarte-Salles, T | 1 |
| Stepien, M | 1 |
| Gunter, M | 1 |
| Murphy, N | 1 |
| Riboli, E | 1 |
| Trichopoulos, D | 1 |
| Dong, S | 1 |
| Kong, J | 2 |
| Shen, Q | 1 |
| Kong, F | 1 |
| Sun, W | 1 |
| Zheng, L | 1 |
| Petrick, JL | 1 |
| Freedman, ND | 1 |
| Graubard, BI | 1 |
| Sahasrabuddhe, VV | 1 |
| Lai, GY | 1 |
| Alavanja, MC | 1 |
| Beane-Freeman, LE | 1 |
| Boggs, DA | 1 |
| Buring, JE | 1 |
| Chan, AT | 1 |
| Chong, DQ | 1 |
| Fuchs, CS | 1 |
| Gapstur, SM | 1 |
| Gaziano, JM | 1 |
| Giovannucci, EL | 1 |
| Hollenbeck, AR | 1 |
| King, LY | 1 |
| Koshiol, J | 1 |
| Lee, IM | 1 |
| Linet, MS | 1 |
| Palmer, JR | 1 |
| Poynter, JN | 1 |
| Purdue, MP | 1 |
| Robien, K | 1 |
| Schairer, C | 1 |
| Sesso, HD | 1 |
| Sigurdson, AJ | 1 |
| Zeleniuch-Jacquotte, A | 1 |
| Wactawski-Wende, J | 1 |
| Campbell, PT | 1 |
| McGlynn, KA | 1 |
| Stępnik, M | 1 |
| Spryszyńska, S | 1 |
| Smok-Pieniążek, A | 1 |
| Ferlińska, M | 1 |
| Roszak, J | 1 |
| Nocuń, M | 1 |
| Salomone, F | 1 |
| Galvano, F | 1 |
| Li Volti, G | 1 |
| Tao, KS | 1 |
| Wang, W | 1 |
| Wang, L | 1 |
| Cao, DY | 1 |
| Li, YQ | 1 |
| Wu, SX | 1 |
| Dou, KF | 1 |
| Mann, CD | 1 |
| Neal, CP | 1 |
| Garcea, G | 1 |
| Manson, MM | 1 |
| Dennison, AR | 1 |
| Berry, DP | 1 |
| Gressner, OA | 1 |
| Wu, JF | 1 |
| Zeng, GL | 1 |
| Shen, W | 1 |
| Yang, M | 1 |
| Wang, F | 1 |
| Tian, L | 1 |
| Hu, WY | 1 |
| Li, XP | 1 |
| Ren, H | 1 |
| Tang, KF | 1 |
| Muriel, P | 1 |
| Arauz, J | 1 |
| Tornai, I | 1 |
| Leung, WW | 1 |
| Ho, SC | 1 |
| Chan, HL | 1 |
| Wong, V | 1 |
| Yeo, W | 1 |
| Mok, TS | 1 |
| Fujimaki, S | 1 |
| Matsuda, Y | 1 |
| Wakai, T | 1 |
| Sanpei, A | 1 |
| Kubota, M | 1 |
| Takamura, M | 1 |
| Yamagiwa, S | 1 |
| Yano, M | 1 |
| Ohkoshi, S | 1 |
| Aoyagi, Y | 1 |
| Fujise, Y | 1 |
| Okano, J | 2 |
| Nagahara, T | 2 |
| Abe, R | 1 |
| Imamoto, R | 1 |
| Murawaki, Y | 2 |
| Thong-Ngam, D | 2 |
| Thumvijit, L | 1 |
| Tangkijvanich, P | 2 |
| Janchai, A | 1 |
| Mahachai, V | 2 |
| Wittayalertpanya, S | 2 |
| BREGADZE, IL | 1 |
| KUZNETSOV, IuV | 1 |
| Higdon, JV | 1 |
| Frei, B | 1 |
| Cadden, IS | 1 |
| Partovi, N | 1 |
| Yoshida, EM | 1 |
| Matsumoto, K | 1 |
| Gurkalo, VK | 1 |
| Zabezhinski, MA | 1 |
| McAleer, WJ | 1 |
| Markus, HZ | 1 |
| Bailey, FJ | 1 |
| Herman, AC | 1 |
| Harder, BJ | 1 |
| Wampler, DE | 1 |
| Miller, WJ | 1 |
| Keller, PM | 1 |
| Buynak, EB | 1 |
| Hilleman, MR | 1 |
| Baker, AL | 1 |
| Kotake, AN | 1 |
| Schoeller, DA | 1 |
| Macklin, AW | 1 |
| Szot, RJ | 1 |
| Johansson, SL | 1 |
| Hasegawa, R | 1 |
| Ogiso, T | 1 |
| Imaida, K | 1 |
| Shirai, T | 1 |
| Ito, N | 1 |
| Kusonsolboon, T | 1 |
| Silins, I | 1 |
| Finnberg, N | 1 |
| Ståhl, A | 1 |
| Högberg, J | 1 |
| Stenius, U | 1 |
| Stoichkov, I | 1 |
| Milushev, A | 1 |
| Todorov, D | 1 |
| McDonagh, JE | 1 |
| Nathan, VV | 1 |
| Bonavia, IC | 1 |
| Moyle, GR | 1 |
| Tanner, AR | 1 |
| Jansen, PL | 1 |
| Chamuleau, RA | 1 |
| van Leeuwen, DJ | 1 |
| Schipper, HG | 1 |
| Busemann-Sokole, E | 1 |
| van der Heyde, MN | 1 |
| Ganapathi, MK | 1 |
| Mackiewicz, A | 1 |
| Samols, D | 1 |
| Brabenec, A | 1 |
| Kushner, I | 1 |
| Schultz, D | 1 |
| Hu, SI | 1 |
| Varagnolo, M | 1 |
| Plebani, M | 1 |
| Mussap, M | 1 |
| Nemetz, L | 1 |
| Paleari, CD | 1 |
| Burlina, A | 1 |
| Siden, EJ | 1 |
| Gifford, A | 1 |
| Baltimore, D | 1 |
| Cappadona, C | 1 |
| Valguarnera, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neuroplastic Alterations of the Motor Cortex by Caffeine: Differences Between Caffeine and Non-caffeine Users and Influence of Vigilance During Stimulation[NCT04011670] | 30 participants (Actual) | Interventional | 2019-07-15 | Completed | |||
| Effect of Coffee and Tea Consumption on Adolescent Weight Control - a Randomized Clinical Trial[NCT05181176] | 63 participants (Anticipated) | Interventional | 2021-01-01 | Recruiting | |||
| Cortical Excitability Changes on the Sensorimotor Cortex Induced by Caffeine Consumption: A TMS Study[NCT03720665] | 30 participants (Actual) | Interventional | 2018-10-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for caffeine and Cancer of Liver
| Article | Year |
|---|---|
Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose-response meta-analysis.
Topics: Caffeine; Carcinoma, Hepatocellular; Coffee; Dose-Response Relationship, Drug; Humans; Liver Neoplas | 2017 |
Coffee Drinking and Reduced Risk of Liver Cancer: Update on Epidemiological Findings and Potential Mechanisms.
Topics: Antioxidants; Caffeine; Cardiovascular Diseases; Chlorogenic Acid; Coffee; Diabetes Mellitus; Drinki | 2019 |
Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis.
Topics: Alkaloids; Caffeine; Carcinogenesis; Chlorogenic Acid; Coffea; Coffee; Gastrointestinal Neoplasms; G | 2019 |
Impact of coffee on liver diseases: a systematic review.
Topics: Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Caffeine; Carcinoma, Hepatocell | 2014 |
Molecular Bases Underlying the Hepatoprotective Effects of Coffee.
Topics: Animals; Caffeine; Chlorogenic Acid; Coffee; Disease Models, Animal; Fatty Liver; Humans; Lipid Meta | 2017 |
Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brassicaceae; Caffeine; Capsaicin; Carcinoma, Hepatocell | 2009 |
Less Smad2 is good for you! A scientific update on coffee's liver benefits.
Topics: Acetylgalactosamine; Animals; Caffeine; Carcinoma, Hepatocellular; Collagen Type I; Connective Tissu | 2009 |
Coffee and liver diseases.
Topics: Animals; Antineoplastic Agents, Phytogenic; Caffeine; Carcinoma, Hepatocellular; Coffee; Diterpenes; | 2010 |
[Role of environmental factors in the etiology of hepatocellular carcinoma].
Topics: Aflatoxins; Alcohol Drinking; Antioxidants; Caffeine; Carcinoma, Hepatocellular; Coffee; Contracepti | 2010 |
Coffee and health: a review of recent human research.
Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee | 2006 |
Coffee and health: a review of recent human research.
Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee | 2006 |
Coffee and health: a review of recent human research.
Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee | 2006 |
Coffee and health: a review of recent human research.
Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee | 2006 |
Coffee and health: a review of recent human research.
Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee | 2006 |
Coffee and health: a review of recent human research.
Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee | 2006 |
Coffee and health: a review of recent human research.
Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee | 2006 |
Coffee and health: a review of recent human research.
Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee | 2006 |
Coffee and health: a review of recent human research.
Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Cardiovascular Diseases; Child; Chlorogenic Acid; Coffee | 2006 |
Review article: possible beneficial effects of coffee on liver disease and function.
Topics: Caffeine; Carcinoma, Hepatocellular; Coffee; Humans; Liver Cirrhosis; Liver Neoplasms; Phosphodieste | 2007 |
Clinical utility of breath tests for the assessment of hepatic function.
Topics: Aminopyrine; Breath Tests; Caffeine; Chemical and Drug Induced Liver Injury; Chronic Disease; Cytoch | 1983 |
1 trial available for caffeine and Cancer of Liver
| Article | Year |
|---|---|
Caffeine clearance study in hepatocellular carcinoma.
Topics: Adult; Aged; Caffeine; Carcinoma, Hepatocellular; Female; Humans; Liver; Liver Cirrhosis; Liver Func | 1999 |
34 other studies available for caffeine and Cancer of Liver
| Article | Year |
|---|---|
Caffeine enhances the anti-tumor effect of 5-fluorouracil via increasing the production of reactive oxygen species in hepatocellular carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; | 2019 |
The combination of coffee compounds attenuates early fibrosis-associated hepatocarcinogenesis in mice: involvement of miRNA profile modulation.
Topics: Alkaloids; Animals; Anticarcinogenic Agents; Caffeine; Carcinoma, Hepatocellular; Cell Line, Tumor; | 2020 |
Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice.
Topics: Aging; Animals; Caffeine; Coffee; Diabetes Mellitus, Type 2; Hyperlipidemias; Insulin-Secreting Cell | 2017 |
Caffeine Has a Synergistic Anticancer Effect with Cisplatin via Inhibiting Fanconi Anemia Group D2 Protein Monoubiquitination in Hepatocellular Carcinoma Cells.
Topics: Antineoplastic Agents; Apoptosis; Caffeine; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferatio | 2017 |
Synergistic cytotoxicity and mechanism of caffeine and lysozyme on hepatoma cell line HepG2.
Topics: Apoptosis; Caffeine; Carcinoma, Hepatocellular; Cell Proliferation; Drug Synergism; Hep G2 Cells; Hu | 2018 |
Association between tea consumption and risk of cancer: a prospective cohort study of 0.5 million Chinese adults.
Topics: Adult; Aged; Alcohol Drinking; Asian People; Breast Neoplasms; Caffeine; China; Colorectal Neoplasms | 2019 |
Coffee consumption delays the hepatitis and suppresses the inflammation related gene expression in the Long-Evans Cinnamon rat.
Topics: Adenosine Triphosphatases; Alanine Transaminase; Animals; Caffeine; Cation Transport Proteins; Cinna | 2014 |
Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.
Topics: Animals; Autophagy; Caffeine; Cell Line, Tumor; Diet, High-Fat; Down-Regulation; Fatty Liver; Hep G2 | 2014 |
Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway.
Topics: Antineoplastic Agents; Apoptosis; Caffeine; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; | 2014 |
Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: multicentre, prospective cohort study.
Topics: Beverages; Caffeine; Carcinoma, Hepatocellular; Case-Control Studies; Coffee; Europe; Female; Humans | 2015 |
Low Concentration of Caffeine Inhibits the Progression of the Hepatocellular Carcinoma via Akt Signaling Pathway.
Topics: Animals; Antineoplastic Agents; Caffeine; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor | 2015 |
Coffee Consumption and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Sex: The Liver Cancer Pooling Project.
Topics: Aged; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Caffeine; Carcinoma, Hepatocellular; Cholangioc | 2015 |
The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.
Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Benzo(a)pyrene; Caffeine; Cell Survival; Chromone | 2015 |
The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Caffeine; Chlorogenic Acid; Coffee; Diterpenes; Huma | 2008 |
[Up-regulation of major histocompatibility complex class I-related molecules A (MICA) induced by 5-aza-2'-deoxycytidine].
Topics: Ataxia Telangiectasia Mutated Proteins; Azacitidine; Caffeine; Carcinoma, Hepatocellular; Cell Cycle | 2009 |
Moderate coffee consumption reduces the risk of hepatocellular carcinoma in hepatitis B chronic carriers: a case-control study.
Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Case-Control Studies; Coffee; Dose-Response Relationship | 2011 |
Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Benzenesulfonates; Caffeine; Carcinom | 2012 |
Preventive effect of caffeine and curcumin on hepato-carcinogenesis in diethylnitrosamine-induced rats.
Topics: Animals; Anticarcinogenic Agents; Caffeine; Carcinoma, Hepatocellular; Curcumin; Diethylnitrosamine; | 2012 |
Caffeine clearance in patients with hepatocellular carcinoma after transcatheter oily chemoembolization treatment.
Topics: Adult; Aged; Analysis of Variance; Caffeine; Carcinoma, Hepatocellular; Chemoembolization, Therapeut | 2002 |
[COMPLICATIONS DURING BROMSULPHALEIN TESTS].
Topics: Caffeine; Calcium; Diphenhydramine; Echinococcosis; Echinococcosis, Hepatic; Hemangiosarcoma; Liver | 1964 |
Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway.
Topics: Antineoplastic Agents; Apoptosis; Caffeine; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; | 2008 |
On participation of the autonomic nervous system in the mechanisms of chemical carcinogenesis.
Topics: Acetylcholinesterase; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; | 1982 |
Production of purified hepatitis B surface antigen from Alexander hepatoma cells grown in artificial capillary units.
Topics: Caffeine; Carcinoma, Hepatocellular; Cell Line; Chromatography, Affinity; Culture Media; Culture Tec | 1983 |
Eighteen month oral study of aspirin, phenacetin and caffeine, in C57Bl/6 mice.
Topics: Animals; Aspirin; Caffeine; Carcinogens; Diet; Female; Kidney; Liver; Liver Neoplasms; Male; Mice; M | 1980 |
Carcinogenicity of analgesics: long-term treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen).
Topics: Acetaminophen; Adenocarcinoma; Analgesics; Animals; Antipyrine; Caffeine; Carcinogens; Carcinoma, Sq | 1981 |
Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
Topics: Administration, Oral; Animals; Biological Assay; Body Weight; Caffeine; Coffee; Diethylnitrosamine; | 1995 |
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
Topics: Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Carcin | 2001 |
[Experiment to potentiate the effect of cyclophosphamide combined with tempidon and caffeine in leukemia L1210 and Lewis hepatic carcinoma].
Topics: Animals; Caffeine; Carcinoma; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation, P | 1978 |
Caffeine clearance by enzyme multiplied immunoassay technique: a simple, inexpensive, and useful indicator of liver function.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Humans; Immunoenzyme Techniques; Liver Cirrhosis; Liver Di | 1991 |
Liver regeneration and restoration of liver function after partial hepatectomy in patients with liver tumors.
Topics: Adult; Aged; Caffeine; Carcinoma, Hepatocellular; Female; Galactose; Hepatectomy; Humans; Liver; Liv | 1990 |
Induction of C-reactive protein by cytokines in human hepatoma cell lines is potentiated by caffeine.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; C-Reactive Protein; Caffeine; Calcimycin; Calcium; Carcinoma | 1990 |
Caffeine as indicator of metabolic functions of microsomal liver enzymes.
Topics: Adult; Caffeine; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Female; Half-Life; | 1989 |
Cyclic AMP induces terminal deoxynucleotidyl transferase in immature B cell leukemia lines.
Topics: Animals; B-Lymphocytes; Bucladesine; Caffeine; Cell Line; Cyclic AMP; DNA Nucleotidylexotransferase; | 1985 |
[Distribution of caffeine in animals with experimental transplantable tumors. Tests with tritium-labeled caffeine for the study of the sensitizing properties].
Topics: Animals; Ascitic Fluid; Caffeine; Carcinoma, Hepatocellular; Kidney; Liver; Liver Neoplasms; Mice; N | 1971 |