Page last updated: 2024-10-24

caffeine and Breast Cancer

caffeine has been researched along with Breast Cancer in 78 studies

Research Excerpts

ExcerptRelevanceReference
"Findings from this meta-analysis suggested that coffee/caffeine might be weakly associated with breast cancer risk for postmenopausal women, and the association for BRCA1 mutation carriers deserves further investigation."8.89Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies. ( Jiang, W; Jiang, X; Wu, Y, 2013)
"The potential association of breast cancer and caffeine intake was examined using international aggregate data."8.77Caffeine ingestion and breast cancer. A negative correlation. ( Phelps, CE; Phelps, HM, 1988)
"We investigated the association of coffee and caffeine with breast cancer (BCa) risk, overall and by ER/PR status."8.12Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use. ( Lane, DS; Lehman, A; McLaughlin, E; Neuhouser, ML; Paskett, E; Rohan, T; Snetselaar, L; Yaghjyan, L, 2022)
"To investigate the effects of caffeine on the proliferation and death of human breast cancer cells MCF-7 and MDA-MB-231."8.02Oxidative Stress in Caffeine Action on the Proliferation and Death of Human Breast Cancer Cells MCF-7 and MDA-MB-231. ( Cecchini, AL; Cecchini, R; Luiz, RC; Machado, KL; Marinello, PC; Silva, CFN; Silva, TNX, 2021)
"Research findings remain inconsistent whether caffeine consumption is associated with invasive breast cancer."8.02Caffeine intake from coffee and tea and invasive breast cancer incidence among postmenopausal women in the Women's Health Initiative. ( Freudenheim, JL; Hovey, KM; LaMonte, MJ; Mu, L; Wactawski-Wende, J; Zheng, KH; Zhu, K, 2021)
"The clinical and experimental findings demonstrate various anticancer properties of caffeine and caffeic acid against both ER(+) and ER(-) breast cancer that may sensitize tumor cells to tamoxifen and reduce breast cancer growth."7.81Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer. ( Holly, JM; Ingvar, C; Jernström, H; Markkula, A; Perks, CM; Rose, C; Rosendahl, AH; Simonsson, M; Zeng, L, 2015)
"Studies of coffee and tea consumption and caffeine intake as risk factors for breast cancer are inconclusive."7.81Prospective study of breast cancer in relation to coffee, tea and caffeine in Sweden. ( Adami, HO; Löf, M; Oh, JK; Sandin, S; Ström, P; Weiderpass, E, 2015)
"The present findings provide a proof of principle that breast cancer myofibroblasts can be inactivated, and thereby caffeine may provide a safe and effective prevention against breast tumor growth/recurrence through inhibition of the procarcinogenic effects of active stromal fibroblasts."7.80Caffeine mediates sustained inactivation of breast cancer-associated myofibroblasts via up-regulation of tumor suppressor genes. ( Aboussekhra, A; Al-Ansari, MM, 2014)
"Associations between caffeine and coffee consumption and breast cancer risk are uncertain, with studies suggesting inverse and null associations."7.79High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype. ( Anderson, LN; Boucher, BA; Cotterchio, M; El-Sohemy, A; Lowcock, EC, 2013)
" The aim of this study was to compare the effect of cisplatin and inositol trisphosphate kinase inhibitor (caffeine) on human breast cancer cell line (MCF-7)."7.77Induction of apoptosis and non-apoptosis in human breast cancer cell line (MCF-7) by cisplatin and caffeine. ( Niknafs, B, 2011)
"Numerous mechanisms for the effects of coffee, tea and caffeine on the risk of breast cancer have been suggested."7.77No association between coffee, tea or caffeine consumption and breast cancer risk in a prospective cohort study. ( Boutron-Ruault, MC; Clavel-Chapelon, F; Fagherazzi, G; Romieu, I; Touillaud, MS, 2011)
"The relation between consumption of coffee, tea and caffeine and risk of breast cancer remains unsettled."7.74Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-up. ( Feskanich, D; Ganmaa, D; Holmes, MD; Hunter, DJ; Li, TY; Lopez-Garcia, E; van Dam, RM; Willett, WC, 2008)
"Prospective data relating caffeine consumption to breast cancer risk are limited."7.74Caffeine consumption and the risk of breast cancer in a large prospective cohort of women. ( Buring, JE; Ishitani, K; Lin, J; Manson, JE; Zhang, SM, 2008)
"In this large cohort of Swedish women, consumption of coffee, tea, and caffeine was not associated with breast cancer incidence."7.71Coffee, tea, and caffeine consumption and breast cancer incidence in a cohort of Swedish women. ( Bergkvist, L; Holmberg, L; Michels, KB; Wolk, A, 2002)
"The UK National Case-Control Study Group has examined the relationship between smoking (both own smoking and passive), alcohol consumption and caffeine consumption and the risk of breast cancer."7.69Alcohol, smoking, passive smoking and caffeine in relation to breast cancer risk in young women. UK National Case-Control Study Group. ( Chilvers, CE; Deacon, JM; Smith, SJ, 1994)
"The association of caffeine intake and postmenopausal breast cancer incidence was assessed among 34,388 Iowa women aged 55-69 years in 1986 and followed through 1990."7.68No association between caffeine intake and postmenopausal breast cancer incidence in the Iowa Women's Health Study. ( Bisgard, KM; Folsom, AR; Kushi, LH; McKenzie, DR; Sellers, TA, 1993)
"The conclusion drawn in a recent paper by Minton and associates (Cancer 1983; 51:1249-1253), that caffeine and an unsaturated fat diet significantly promoted dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats, is based on fallacious statistical reasoning."7.67Statistical errors invalidate conclusions in "Caffeine and unsaturated fat diet significantly promotes DMBA-induced breast cancer in rats". ( Bernstein, L; Pike, MC, 1985)
"Breast cancer is the second most common malignancy among women."5.62Chimarrão consumption and prognostic factors in breast cancer: Correlation with antioxidants and blood caffeine levels. ( Bastos, FF; Bastos, VLFDC; Bastos-Neto, JDC; Calixto, MRP; Davis, RAH; de Lima, JR; Dos Santos, VL; Fagundes, TR; Madeira, TB; Nixdorf, SL; Panis, C; Rech, D; Victorino, VJ; Zanandrea, AC, 2021)
"Caffeine, which has been linked to benign breast disease, has an antineoplastic effect in experimental animals, whereas in tissue cultures it inhibits mitoses and induces cell differentiation."5.27Association of tumor differentiation with caffeine and coffee intake in women with breast cancer. ( Aufses, AH; Fagerstrom, R; Feinberg, M; Papatestas, AE; Pozner, J; Saevitz, J; Schwartz, I, 1986)
"Findings from this meta-analysis suggested that coffee/caffeine might be weakly associated with breast cancer risk for postmenopausal women, and the association for BRCA1 mutation carriers deserves further investigation."4.89Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies. ( Jiang, W; Jiang, X; Wu, Y, 2013)
"The potential association of breast cancer and caffeine intake was examined using international aggregate data."4.77Caffeine ingestion and breast cancer. A negative correlation. ( Phelps, CE; Phelps, HM, 1988)
"We investigated the association of coffee and caffeine with breast cancer (BCa) risk, overall and by ER/PR status."4.12Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use. ( Lane, DS; Lehman, A; McLaughlin, E; Neuhouser, ML; Paskett, E; Rohan, T; Snetselaar, L; Yaghjyan, L, 2022)
"To investigate the effects of caffeine on the proliferation and death of human breast cancer cells MCF-7 and MDA-MB-231."4.02Oxidative Stress in Caffeine Action on the Proliferation and Death of Human Breast Cancer Cells MCF-7 and MDA-MB-231. ( Cecchini, AL; Cecchini, R; Luiz, RC; Machado, KL; Marinello, PC; Silva, CFN; Silva, TNX, 2021)
"Research findings remain inconsistent whether caffeine consumption is associated with invasive breast cancer."4.02Caffeine intake from coffee and tea and invasive breast cancer incidence among postmenopausal women in the Women's Health Initiative. ( Freudenheim, JL; Hovey, KM; LaMonte, MJ; Mu, L; Wactawski-Wende, J; Zheng, KH; Zhu, K, 2021)
"Coffee contains caffeine and diterpenes that were associated with decreased breast cancer risk, but results remained inconsistent."3.91Associations between Coffee Products and Breast Cancer Risk: a Case-Control study in Hong Kong Chinese Women. ( Chan, WC; Chang, LDJ; Kwok, CC; Law, SH; Lee, PMY; Tsang, KH; Tse, LA; Wang, F; Wong, CKM; Wu, C; Yeung, YC; Yu, WC, 2019)
"Previous studies suggest that coffee and caffeine intake may be associated with reduced breast cancer risk."3.88Associations of coffee consumption and caffeine intake with mammographic breast density. ( Colditz, G; Gasparova, A; Rosner, B; Tamimi, RM; Yaghjyan, L, 2018)
"Our findings suggest that coffee and/or caffeine may be associated with reduced risk of endometrial cancer but, probably, associated increased with risk of breast cancer among premenopausal or normal weight women."3.88Associations of coffee, tea and caffeine intake with risk of breast, endometrial and ovarian cancer among Canadian women. ( Arthur, R; Kirsh, VA; Rohan, TE, 2018)
"The clinical and experimental findings demonstrate various anticancer properties of caffeine and caffeic acid against both ER(+) and ER(-) breast cancer that may sensitize tumor cells to tamoxifen and reduce breast cancer growth."3.81Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer. ( Holly, JM; Ingvar, C; Jernström, H; Markkula, A; Perks, CM; Rose, C; Rosendahl, AH; Simonsson, M; Zeng, L, 2015)
"Studies of coffee and tea consumption and caffeine intake as risk factors for breast cancer are inconclusive."3.81Prospective study of breast cancer in relation to coffee, tea and caffeine in Sweden. ( Adami, HO; Löf, M; Oh, JK; Sandin, S; Ström, P; Weiderpass, E, 2015)
"The aim of the present study was to evaluate the relative contribution of CYP1A2 isoforms (-3860 G/A, -2467T/delT and -163C/A) in control subjects and breast cancer patients to the metabolism of caffeine in human liver."3.81Breast Cancer Association with CYP1A2 Activity and Gene Polymorphisms--a Preliminary Case-control Study in Tunisia. ( Arij, M; Imene, A; Maurice, AJ; Saad, S; Sofia, P, 2015)
"The present findings provide a proof of principle that breast cancer myofibroblasts can be inactivated, and thereby caffeine may provide a safe and effective prevention against breast tumor growth/recurrence through inhibition of the procarcinogenic effects of active stromal fibroblasts."3.80Caffeine mediates sustained inactivation of breast cancer-associated myofibroblasts via up-regulation of tumor suppressor genes. ( Aboussekhra, A; Al-Ansari, MM, 2014)
"Associations between caffeine and coffee consumption and breast cancer risk are uncertain, with studies suggesting inverse and null associations."3.79High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype. ( Anderson, LN; Boucher, BA; Cotterchio, M; El-Sohemy, A; Lowcock, EC, 2013)
"Capsaicin treatment was previously reported to reduce the sensitivity of breast cancer cells, but not normal MCF10A cells, to apoptosis."3.78Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1. ( Ahn, SG; Jung, SH; Lee, BH; Oh, SH; Yoon, JH, 2012)
"Our findings suggest that coffee, black tea, and caffeine consumption before breast cancer diagnosis do not influence breast cancer-specific and overall survival."3.78Coffee and black tea consumption and breast cancer mortality in a cohort of Swedish women. ( Bergkvist, L; Harris, HR; Wolk, A, 2012)
" The aim of this study was to compare the effect of cisplatin and inositol trisphosphate kinase inhibitor (caffeine) on human breast cancer cell line (MCF-7)."3.77Induction of apoptosis and non-apoptosis in human breast cancer cell line (MCF-7) by cisplatin and caffeine. ( Niknafs, B, 2011)
"Numerous mechanisms for the effects of coffee, tea and caffeine on the risk of breast cancer have been suggested."3.77No association between coffee, tea or caffeine consumption and breast cancer risk in a prospective cohort study. ( Boutron-Ruault, MC; Clavel-Chapelon, F; Fagherazzi, G; Romieu, I; Touillaud, MS, 2011)
"Our findings suggest that intakes of tea, coffee, and caffeine are not associated with the risk of breast cancer among African-American women."3.76Tea and coffee intake in relation to risk of breast cancer in the Black Women's Health Study. ( Adams-Campbell, LL; Boggs, DA; Palmer, JR; Rosenberg, L; Spiegelman, D; Stampfer, MJ, 2010)
"Prospective data relating caffeine consumption to breast cancer risk are limited."3.74Caffeine consumption and the risk of breast cancer in a large prospective cohort of women. ( Buring, JE; Ishitani, K; Lin, J; Manson, JE; Zhang, SM, 2008)
"The relation between consumption of coffee, tea and caffeine and risk of breast cancer remains unsettled."3.74Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-up. ( Feskanich, D; Ganmaa, D; Holmes, MD; Hunter, DJ; Li, TY; Lopez-Garcia, E; van Dam, RM; Willett, WC, 2008)
"Caffeine has been suggested as a possible risk factor for breast cancer, potentially through its effect of facilitating the development of benign breast disease."3.73Consumption of coffee, but not black tea, is associated with decreased risk of premenopausal breast cancer. ( Baker, JA; Beehler, GP; Jayaprakash, V; McCann, SE; Moysich, KB; Sawant, AC, 2006)
"To describe the baseline healthy lifestyle behaviors (dietary, calcium, vitamin D, caffeine and alcohol intake, smoking history, and physical activity) of postmenopausal breast cancer survivors (BCS); and to identify any relationship of healthy lifestyle behaviors with bone mineral density (BMD) at the forearm, total hip and spine, L1-L4."3.73Health behaviors in breast cancer survivors experiencing bone loss. ( Gross, GJ; Lindsey, AM; Ott, CD; Twiss, JJ; Waltman, NL, 2006)
"In this large cohort of Swedish women, consumption of coffee, tea, and caffeine was not associated with breast cancer incidence."3.71Coffee, tea, and caffeine consumption and breast cancer incidence in a cohort of Swedish women. ( Bergkvist, L; Holmberg, L; Michels, KB; Wolk, A, 2002)
"Caffeine intake has been proposed to influence breast cancer risk."3.70Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women. ( Kabuto, M; Nagata, C; Shimizu, H, 1998)
"The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex- and age-matched normal controls."3.70Common fragile site expression and genetic predisposition to breast cancer. ( Ceçener, G; Duman, H; Egeli, U; Kizil, A; Taşdelen, I; Tunca, B, 1998)
"The UK National Case-Control Study Group has examined the relationship between smoking (both own smoking and passive), alcohol consumption and caffeine consumption and the risk of breast cancer."3.69Alcohol, smoking, passive smoking and caffeine in relation to breast cancer risk in young women. UK National Case-Control Study Group. ( Chilvers, CE; Deacon, JM; Smith, SJ, 1994)
"A study of MCF-7 human breast cancer cells was undertaken to ascertain the degree of apoptosis induction by paclitaxel and if the induction of apoptosis could be enhanced by caffeine."3.69Paclitaxel-induced apoptosis in MCF-7 breast-cancer cells. ( Christensen, C; Deppe, G; Lawrence, WD; Ruan, H; Saunders, DE; Wappler, NL, 1997)
"The association of caffeine intake and postmenopausal breast cancer incidence was assessed among 34,388 Iowa women aged 55-69 years in 1986 and followed through 1990."3.68No association between caffeine intake and postmenopausal breast cancer incidence in the Iowa Women's Health Study. ( Bisgard, KM; Folsom, AR; Kushi, LH; McKenzie, DR; Sellers, TA, 1993)
"The conclusion drawn in a recent paper by Minton and associates (Cancer 1983; 51:1249-1253), that caffeine and an unsaturated fat diet significantly promoted dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats, is based on fallacious statistical reasoning."3.67Statistical errors invalidate conclusions in "Caffeine and unsaturated fat diet significantly promotes DMBA-induced breast cancer in rats". ( Bernstein, L; Pike, MC, 1985)
"Dietary polyphenols may protect against breast cancer."2.90Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues from Breast Cancer Patients. ( Abellán, B; Ávila-Gálvez, MÁ; Espín, JC; García-Villalba, R; González-Sarrías, A; Martínez-Díaz, F; Monedero-Saiz, T; Ocaña-Castillo, B; Torrecillas-Sánchez, A, 2019)
"Among the 48 human ABC proteins, the breast cancer resistance protein (BCRP/ABCG2) has been described as a pivotal player in cancer resistance."2.82Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. ( Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF, 2022)
"Coffee is inversely associated with breast cancer risk in postmenopausal women and in women carrying a BRCA1 mutation."2.72Coffee consumption and breast cancer risk: a narrative review in the general population and in different subtypes of breast cancer. ( Arbogast, P; Mathelin, C; Nehlig, A; Reix, N, 2021)
"Breast cancer is the second most common malignancy among women."1.62Chimarrão consumption and prognostic factors in breast cancer: Correlation with antioxidants and blood caffeine levels. ( Bastos, FF; Bastos, VLFDC; Bastos-Neto, JDC; Calixto, MRP; Davis, RAH; de Lima, JR; Dos Santos, VL; Fagundes, TR; Madeira, TB; Nixdorf, SL; Panis, C; Rech, D; Victorino, VJ; Zanandrea, AC, 2021)
"22,652 incident cancers occurred during 10."1.51Association between tea consumption and risk of cancer: a prospective cohort study of 0.5 million Chinese adults. ( Bian, Z; Chen, F; Chen, J; Chen, Y; Chen, Z; Guo, Y; Li, L; Li, X; Lv, J; Qiu, Z; Shen, Z; Wei, Y; Yang, L; Yu, C; Zhang, H, 2019)
"Colorectal and breast cancer cell lineages, HT-29 and MCF-7 cells, respectively, were exposed to different guaraná concentrations (0."1.46Guaraná, a Highly Caffeinated Food, Presents in vitro Antitumor Activity in Colorectal and Breast Cancer Cell Lines by Inhibiting AKT/mTOR/S6K and MAPKs Pathways. ( Assmann, CE; Azzolin, VF; Cadoná, FC; Cubillos-Rojas, M; da Cruz, IBM; Machado, AK; Ribeiro, EE; Rosa, JL; Sánchez-Tena, S; Schneider, T, 2017)
"We have shown here that breast cancer cells and IL-6 persistently activate breast stromal fibroblasts through the stimulation of the positive IL-6/STAT3/NF-κB feedback loop."1.43The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts. ( Aboussekhra, A; Al-Ansari, MM; Al-Harbi, B; Hendrayani, SF; Silva, G, 2016)
"The CYP1A2 genotype did not affect breast cancer risk."1.34The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers. ( Daly, M; Domchek, S; El-Sohemy, A; Ghadirian, P; Karlan, B; Kotsopoulos, J; Lynch, HT; Narod, SA; Randall, S; Snyder, C; Sun, P; Zhang, P; Zhang, S, 2007)
"There was no increased risk for ovarian cancer associated with possession of either the Msp1 or Ile/Val polymorphism of CYP1A1."1.32Interaction between CYP1A1 polymorphic variants and dietary exposures influencing ovarian cancer risk. ( Cramer, DW; Garner, EO; Terry, KL; Titus-Ernstoff, L; Vitonis, AF, 2003)
"Caffeine, which has been linked to benign breast disease, has an antineoplastic effect in experimental animals, whereas in tissue cultures it inhibits mitoses and induces cell differentiation."1.27Association of tumor differentiation with caffeine and coffee intake in women with breast cancer. ( Aufses, AH; Fagerstrom, R; Feinberg, M; Papatestas, AE; Pozner, J; Saevitz, J; Schwartz, I, 1986)

Research

Studies (78)

TimeframeStudies, this research(%)All Research%
pre-199012 (15.38)18.7374
1990's13 (16.67)18.2507
2000's18 (23.08)29.6817
2010's27 (34.62)24.3611
2020's8 (10.26)2.80

Authors

AuthorsStudies
Qi, Q1
Obianyo, O1
Du, Y1
Fu, H1
Li, S1
Ye, K1
Zattoni, IF1
Delabio, LC1
Dutra, JP1
Kita, DH1
Scheiffer, G1
Hembecker, M1
Pereira, GDS1
Moure, VR1
Valdameri, G1
Yaghjyan, L2
McLaughlin, E1
Lehman, A1
Neuhouser, ML1
Rohan, T1
Lane, DS1
Snetselaar, L1
Paskett, E1
Lee, PMY1
Chan, WC1
Kwok, CC1
Wu, C1
Law, SH1
Tsang, KH1
Yu, WC1
Yeung, YC1
Chang, LDJ1
Wong, CKM1
Wang, F1
Tse, LA1
Machado, KL1
Marinello, PC1
Silva, TNX1
Silva, CFN1
Luiz, RC1
Cecchini, R1
Cecchini, AL1
McEligot, AJ1
Poynor, V1
Sharma, R1
Panangadan, A1
Calixto, MRP1
Rech, D1
Dos Santos, VL1
Madeira, TB1
Nixdorf, SL1
Fagundes, TR1
Davis, RAH1
Bastos, FF1
Bastos-Neto, JDC1
Bastos, VLFDC1
Zanandrea, AC1
de Lima, JR1
Victorino, VJ1
Panis, C1
Nehlig, A1
Reix, N1
Arbogast, P1
Mathelin, C1
Wang, S1
Li, X2
Yang, Y1
Xie, J1
Liu, M1
Zhang, Y2
Zhao, Q1
Zheng, KH1
Zhu, K1
Wactawski-Wende, J1
Freudenheim, JL1
LaMonte, MJ1
Hovey, KM1
Mu, L1
Acar, E1
Gürdeniz, G1
Savorani, F1
Hansen, L1
Olsen, A1
Tjønneland, A1
Dragsted, LO1
Bro, R1
Cadoná, FC1
Rosa, JL1
Schneider, T1
Cubillos-Rojas, M1
Sánchez-Tena, S1
Azzolin, VF1
Assmann, CE1
Machado, AK1
Ribeiro, EE1
da Cruz, IBM1
Colditz, G1
Rosner, B1
Gasparova, A1
Tamimi, RM1
Arthur, R1
Kirsh, VA1
Rohan, TE2
Ávila-Gálvez, MÁ1
García-Villalba, R1
Martínez-Díaz, F1
Ocaña-Castillo, B1
Monedero-Saiz, T1
Torrecillas-Sánchez, A1
Abellán, B1
González-Sarrías, A1
Espín, JC1
Yu, C1
Guo, Y1
Bian, Z1
Shen, Z1
Yang, L1
Chen, Y1
Wei, Y1
Zhang, H1
Qiu, Z1
Chen, J1
Chen, F1
Chen, Z2
Lv, J1
Li, L1
Lowcock, EC1
Cotterchio, M1
Anderson, LN1
Boucher, BA1
El-Sohemy, A2
Jiang, W1
Wu, Y1
Jiang, X2
Claes, K1
Depuydt, J1
Taylor, AM1
Last, JI1
Baert, A1
Schietecatte, P1
Vandersickel, V1
Poppe, B1
De Leeneer, K1
D'Hooghe, M1
Vral, A1
Martins, IL1
Miranda, JP1
Oliveira, NG1
Fernandes, AS1
Gonçalves, S1
Antunes, AM1
Lin, JN1
Lin, HY1
Yang, NS1
Li, YH1
Lee, MR1
Chuang, CH1
Ho, CT1
Kuo, SC1
Way, TD1
Al-Ansari, MM2
Aboussekhra, A2
Rosendahl, AH1
Perks, CM1
Zeng, L1
Markkula, A1
Simonsson, M1
Rose, C1
Ingvar, C1
Holly, JM1
Jernström, H1
Oh, JK1
Sandin, S1
Ström, P1
Löf, M1
Adami, HO1
Weiderpass, E1
Imene, A1
Maurice, AJ1
Arij, M1
Sofia, P1
Saad, S1
Nikitina, D1
Vallis, K1
Poll, A1
Ainsworth, P1
Narod, SA2
Kotsopoulos, J3
Hendrayani, SF1
Al-Harbi, B1
Silva, G1
Ishitani, K1
Lin, J1
Manson, JE1
Buring, JE1
Zhang, SM1
Tang, N1
Zhou, B1
Wang, B1
Yu, R1
Eliassen, AH1
Missmer, SA1
Hankinson, SE1
Tworoger, SS1
Boggs, DA1
Palmer, JR1
Stampfer, MJ1
Spiegelman, D1
Adams-Campbell, LL2
Rosenberg, L2
Fagherazzi, G1
Touillaud, MS1
Boutron-Ruault, MC1
Clavel-Chapelon, F1
Romieu, I1
Gierach, GL1
Freedman, ND1
Andaya, A1
Hollenbeck, AR1
Park, Y1
Schatzkin, A1
Brinton, LA2
Yoon, JH1
Ahn, SG1
Lee, BH1
Jung, SH1
Oh, SH1
Niknafs, B1
Johnson, JK1
Waddell, N1
Chenevix-Trench, G1
Mitchell, A1
McCrea, P1
Inglis, K1
Porter, G1
Harris, HR1
Bergkvist, L2
Wolk, A2
Terry, KL1
Titus-Ernstoff, L1
Garner, EO1
Vitonis, AF1
Cramer, DW1
Essmann, F1
Engels, IH1
Totzke, G1
Schulze-Osthoff, K2
Jänicke, RU1
Pobst, LJ1
Ames, MM1
Wendt, J1
Radetzki, S1
von Haefen, C1
Hemmati, PG1
Güner, D1
Dörken, B1
Daniel, PT1
Baker, JA1
Beehler, GP1
Sawant, AC1
Jayaprakash, V1
McCann, SE1
Moysich, KB1
Natarajan, TG1
Ganesan, N1
Carter-Nolan, P1
Tucker, CA1
Shields, PG1
Twiss, JJ1
Gross, GJ1
Waltman, NL1
Ott, CD1
Lindsey, AM1
Ghadirian, P1
Lynch, HT1
Snyder, C1
Daly, M1
Domchek, S1
Randall, S1
Karlan, B1
Zhang, P1
Zhang, S1
Sun, P1
Ganmaa, D1
Willett, WC1
Li, TY1
Feskanich, D1
van Dam, RM1
Lopez-Garcia, E1
Hunter, DJ1
Holmes, MD1
Li, Z1
Liu, W1
Mo, B1
Hu, C1
Liu, H1
Qi, H1
Wang, X1
Xu, J1
Barber, R1
Goka, TJ1
Butcher, RW1
Brooks, PG1
Welsch, CW2
el-Bayoumy, K1
Smith, SJ1
Deacon, JM1
Chilvers, CE1
Folsom, AR1
McKenzie, DR1
Bisgard, KM1
Kushi, LH1
Sellers, TA1
Monnin, S1
Schiller, MR1
Sachs, L1
Smith, AM1
Vineis, P1
Saunders, DE1
Lawrence, WD1
Christensen, C1
Wappler, NL1
Ruan, H1
Deppe, G1
Nagata, C1
Kabuto, M1
Shimizu, H1
Tavani, A1
Pregnolato, A1
La Vecchia, C1
Favero, A1
Franceschi, S1
Ceçener, G1
Egeli, U1
Taşdelen, I1
Tunca, B1
Duman, H1
Kizil, A1
Valenzuela, MT1
Mateos, S1
Ruiz de Almodóvar, JM1
McMillan, TJ1
Lim, LY1
Daly, JW1
Li, AH1
Jacobson, KA1
Roberge, M1
Matsuoka, M1
Igisu, H1
Michels, KB1
Holmberg, L1
Jha, MN1
Bamburg, JR1
Bernstein, BW1
Bedford, JS1
McLaughlin, CC1
Mahoney, MC1
Nasca, PC1
Metzger, BB1
Baptiste, MS1
Field, NA1
Wolfrom, D1
Lubin, F2
Ron, E2
Schairer, C1
Hoover, RN1
Phelps, HM1
Phelps, CE1
McMichael, AJ1
Jackson, VP1
Lex, AM1
Smith, DJ1
Cerrato, PL1
Pozner, J1
Papatestas, AE1
Fagerstrom, R1
Schwartz, I1
Saevitz, J1
Feinberg, M1
Aufses, AH1
Wax, Y1
Modan, B1
Pozniak, PC1
Pike, MC1
Bernstein, L1
Miller, DR1
Helmrich, SP1
Kaufman, DW1
Schottenfeld, D1
Stolley, PD1
Shapiro, S1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Post-operative Analgesia in Elective, Soft-tissue Hand Surgery: A Randomized, Double Blind Comparison of Acetaminophen/Ibuprofen Versus Acetaminophen/Hydrocodone[NCT02029235]Phase 472 participants (Actual)Interventional2015-02-10Terminated (stopped due to Early termination due to slower than anticipated recruitment.)
Prevention of Osteoporosis in Breast Cancer Survivors[NCT00567606]249 participants (Actual)Interventional2002-04-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Efficacy Comparison of Pain Intensity Level

"Subjects asked to fill out a patient diary recording their pain intensity level (on 100mm Visual Analog Scale) prior to taking study medication every 4 hours.~The daily average pain intensity levels are reported as a score on a scale of 0-100, with higher score meaning worse outcome.~The daily average pain levels were assessed daily for 1 week post-operatively, then compared between the 2 groups using a two-group Student's t-test." (NCT02029235)
Timeframe: 1 week post-operatively

,
Interventionscore on a scale (0-100, higher = worse) (Mean)
Daily average pain intensity level on PostOp Day 1Daily average pain intensity level on PostOp Day 2Daily average pain intensity level on PostOp Day 3Daily average pain intensity levelon PostOp Day 4Daily average pain intensity level on PostOp Day 5Daily average pain intensity level on PostOp Day 6Daily average pain intensity level on PostOp Day 7
Acetaminophen/Hydrocodone (AH) Group24.0730.1622.1118.5316.6113.5813.00
Acetaminophen/Ibuprofen (AIBU) Group22.1722.2215.6713.1714.0313.4412.67

Efficacy Comparison of Pain Relief

"Subjects asked to fill out a patient diary recording their pain relief (on a Likert scale) one hour after taking study medication every 4 hours.~Daily average pain relief scores are reported as a score on a scale of 0-3, with higher score meaning better outcome.~The daily average pain relief scores were assessed daily for 1 week post-operatively, then compared using generalized linear mixed-effects models" (NCT02029235)
Timeframe: 1 week postoperatively

,
Interventionscore on a scale (0-3, higher = better) (Mean)
Daily average pain relief on PostOp Day 1Daily average pain relief on PostOp Day 2Daily average pain relief on PostOp Day 3Daily average pain relief on PostOp Day 4Daily average pain relief on PostOp Day 5Daily average pain relief on PostOp Day 6Daily average pain relief on PostOp Day 7
Acetaminophen/Hydrocodone (AH) Group1.531.762.332.462.542.842.88
Acetaminophen/Ibuprofen (AIBU) Group1.842.272.632.912.882.872.96

Reviews

11 reviews available for caffeine and Breast Cancer

ArticleYear
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Dr

2022
Coffee consumption and breast cancer risk: a narrative review in the general population and in different subtypes of breast cancer.
    European journal of nutrition, 2021, Volume: 60, Issue:3

    Topics: Breast Neoplasms; Caffeine; Coffee; Female; Humans; Premenopause; Risk Factors; Tamoxifen

2021
Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis.
    Public health nutrition, 2021, Volume: 24, Issue:18

    Topics: Breast Neoplasms; Caffeine; Coffee; Female; Humans; Network Meta-Analysis; Prospective Studies; Risk

2021
Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies.
    Gynecologic oncology, 2013, Volume: 129, Issue:3

    Topics: Breast Neoplasms; Caffeine; Case-Control Studies; Coffee; Dose-Response Relationship, Drug; Female;

2013
Coffee consumption and risk of breast cancer: a metaanalysis.
    American journal of obstetrics and gynecology, 2009, Volume: 200, Issue:3

    Topics: Breast Neoplasms; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Coffee; Cohort

2009
Caffeine and the development of the normal and neoplastic mammary gland.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1994, Volume: 207, Issue:1

    Topics: Animals; Breast Diseases; Breast Neoplasms; Caffeine; Female; Mammary Glands, Animal; Mammary Neopla

1994
Evaluation of chemopreventive agents against breast cancer and proposed strategies for future clinical intervention trials.
    Carcinogenesis, 1994, Volume: 15, Issue:11

    Topics: Animals; Anticarcinogenic Agents; Arachidonic Acid; Breast Neoplasms; Caffeine; Cyclohexenes; Female

1994
Caffeine and the development of normal, benign and carcinomatous human breast tissues: a relationship?
    Journal of medicine, 1990, Volume: 21, Issue:5

    Topics: Animals; Breast; Breast Diseases; Breast Neoplasms; Caffeine; Fibrocystic Breast Disease; Humans; Ma

1990
Consumption of methylxanthine-containing beverages and the risk of breast cancer.
    Cancer letters, 1990, Volume: 53, Issue:2-3

    Topics: Beverages; Breast Neoplasms; Caffeine; Case-Control Studies; Female; Humans; Xanthines

1990
Caffeine ingestion and breast cancer. A negative correlation.
    Cancer, 1988, Mar-01, Volume: 61, Issue:5

    Topics: Breast Neoplasms; Caffeine; Dietary Fats; Humans; Regression Analysis

1988
The carcinogenicity of caffeine and coffee: a review.
    Journal of the American Dietetic Association, 1985, Volume: 85, Issue:9

    Topics: Breast Neoplasms; Caffeine; Coffee; Epidemiologic Methods; Female; Humans; Intestinal Neoplasms; Kin

1985

Trials

2 trials available for caffeine and Breast Cancer

ArticleYear
Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues from Breast Cancer Patients.
    Molecular nutrition & food research, 2019, Volume: 63, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Breast Neoplasms, Male; Caffeine; Cell Prolife

2019
A randomized, controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine (Tylenol 3) after outpatient breast surgery.
    Annals of surgical oncology, 2012, Volume: 19, Issue:12

    Topics: Acetaminophen; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Breast Neoplasms; Ca

2012

Other Studies

65 other studies available for caffeine and Breast Cancer

ArticleYear
Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.
    Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17

    Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Cysteine Endopeptidases;

2017
Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use.
    European journal of nutrition, 2022, Volume: 61, Issue:7

    Topics: Breast Neoplasms; Caffeine; Female; Hormones; Humans; Postmenopause; Risk Factors

2022
Associations between Coffee Products and Breast Cancer Risk: a Case-Control study in Hong Kong Chinese Women.
    Scientific reports, 2019, 09-03, Volume: 9, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Asian People; Breast Neoplasms; Caffeine; Case-Control Studies; Coff

2019
Oxidative Stress in Caffeine Action on the Proliferation and Death of Human Breast Cancer Cells MCF-7 and MDA-MB-231.
    Nutrition and cancer, 2021, Volume: 73, Issue:8

    Topics: Apoptosis; Breast Neoplasms; Caffeine; Cell Line, Tumor; Cell Proliferation; Female; Humans; MCF-7 C

2021
Logistic LASSO Regression for Dietary Intakes and Breast Cancer.
    Nutrients, 2020, Aug-31, Volume: 12, Issue:9

    Topics: Alcohol Drinking; Body Mass Index; Breast Neoplasms; Caffeine; Cross-Sectional Studies; Demography;

2020
Chimarrão consumption and prognostic factors in breast cancer: Correlation with antioxidants and blood caffeine levels.
    Phytotherapy research : PTR, 2021, Volume: 35, Issue:2

    Topics: Antioxidants; Breast Neoplasms; Caffeine; Female; Humans; Male; Middle Aged; Plant Leaves; Prognosis

2021
Caffeine intake from coffee and tea and invasive breast cancer incidence among postmenopausal women in the Women's Health Initiative.
    International journal of cancer, 2021, 12-15, Volume: 149, Issue:12

    Topics: Aged; Breast Neoplasms; Caffeine; Carcinoma, Ductal, Breast; Coffee; Diet Surveys; Female; Follow-Up

2021
Forecasting Chronic Diseases Using Data Fusion.
    Journal of proteome research, 2017, 07-07, Volume: 16, Issue:7

    Topics: Acute Coronary Syndrome; Biomarkers; Breast Neoplasms; Caffeine; Chromatography, Liquid; Chronic Dis

2017
Guaraná, a Highly Caffeinated Food, Presents in vitro Antitumor Activity in Colorectal and Breast Cancer Cell Lines by Inhibiting AKT/mTOR/S6K and MAPKs Pathways.
    Nutrition and cancer, 2017, Volume: 69, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Caffeine; Cell Line, Tumor; Colorectal Neoplasm

2017
Associations of coffee consumption and caffeine intake with mammographic breast density.
    Breast cancer research and treatment, 2018, Volume: 169, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Breast Density; Breast Neoplasms; Caffeine; Coffee; Feeding Behavior

2018
Associations of coffee, tea and caffeine intake with risk of breast, endometrial and ovarian cancer among Canadian women.
    Cancer epidemiology, 2018, Volume: 56

    Topics: Adult; Aged; Breast Neoplasms; Caffeine; Canada; Coffee; Endometrial Neoplasms; Female; Humans; Life

2018
Association between tea consumption and risk of cancer: a prospective cohort study of 0.5 million Chinese adults.
    European journal of epidemiology, 2019, Volume: 34, Issue:8

    Topics: Adult; Aged; Alcohol Drinking; Asian People; Breast Neoplasms; Caffeine; China; Colorectal Neoplasms

2019
High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype.
    Nutrition and cancer, 2013, Volume: 65, Issue:3

    Topics: Adult; Aged; Breast Neoplasms; Caffeine; Case-Control Studies; Coffee; Cytochrome P-450 CYP1A2; Diet

2013
Variant ataxia telangiectasia: clinical and molecular findings and evaluation of radiosensitive phenotypes in a patient and relatives.
    Neuromolecular medicine, 2013, Volume: 15, Issue:3

    Topics: Adult; Amino Acid Substitution; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Breas

2013
Synthesis and biological activity of 6-selenocaffeine: potential modulator of chemotherapeutic drugs in breast cancer cells.
    Molecules (Basel, Switzerland), 2013, May-08, Volume: 18, Issue:5

    Topics: Antibiotics, Antineoplastic; Antioxidants; Breast Neoplasms; Caffeine; Cell Line, Tumor; Doxorubicin

2013
Chemical constituents and anticancer activity of yellow camellias against MDA-MB-231 human breast cancer cells.
    Journal of agricultural and food chemistry, 2013, Oct-09, Volume: 61, Issue:40

    Topics: Amino Acids; Antineoplastic Agents, Phytogenic; Antioxidants; Breast Neoplasms; Caffeine; Camellia;

2013
Caffeine mediates sustained inactivation of breast cancer-associated myofibroblasts via up-regulation of tumor suppressor genes.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Breast Neoplasms; Caffeine; Caveolin 1; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kina

2014
Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Apr-15, Volume: 21, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Caffeic Acids; Caffeine; Cell C

2015
Prospective study of breast cancer in relation to coffee, tea and caffeine in Sweden.
    International journal of cancer, 2015, Oct-15, Volume: 137, Issue:8

    Topics: Adult; Breast Neoplasms; Caffeine; Coffee; Female; Follow-Up Studies; Humans; Middle Aged; Prospecti

2015
Breast Cancer Association with CYP1A2 Activity and Gene Polymorphisms--a Preliminary Case-control Study in Tunisia.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:8

    Topics: Breast Neoplasms; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Female; Genetic Predispos

2015
Relationship between Caffeine and Levels of DNA Repair and Oxidative Stress in Women with and without a BRCA1 Mutation.
    Journal of nutrigenetics and nutrigenomics, 2015, Volume: 8, Issue:4-6

    Topics: Adult; Aged; Breast Neoplasms; Caffeine; Case-Control Studies; Coffee; DNA Repair; Drinking Behavior

2015
The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts.
    Oncotarget, 2016, Jul-05, Volume: 7, Issue:27

    Topics: Breast; Breast Neoplasms; Caffeine; Cancer-Associated Fibroblasts; Cell Line; Cell Line, Tumor; Cell

2016
Caffeine consumption and the risk of breast cancer in a large prospective cohort of women.
    Archives of internal medicine, 2008, Oct-13, Volume: 168, Issue:18

    Topics: Breast Neoplasms; Caffeine; Confidence Intervals; Female; Follow-Up Studies; Humans; Incidence; Midd

2008
Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women.
    Cancer, 2009, Jun-15, Volume: 115, Issue:12

    Topics: Adult; Breast Neoplasms; Caffeine; Coffee; Diet; Female; Gonadal Steroid Hormones; Humans; Middle Ag

2009
Tea and coffee intake in relation to risk of breast cancer in the Black Women's Health Study.
    Cancer causes & control : CCC, 2010, Volume: 21, Issue:11

    Topics: Adult; Aged; Black or African American; Breast Neoplasms; Caffeine; Coffee; Cohort Studies; Female;

2010
No association between coffee, tea or caffeine consumption and breast cancer risk in a prospective cohort study.
    Public health nutrition, 2011, Volume: 14, Issue:7

    Topics: Beverages; Breast Neoplasms; Caffeine; Coffee; Cohort Studies; Diet Surveys; Female; Follow-Up Studi

2011
Coffee intake and breast cancer risk in the NIH-AARP diet and health study cohort.
    International journal of cancer, 2012, Jul-15, Volume: 131, Issue:2

    Topics: Aged; Breast Neoplasms; Caffeine; Coffee; Cohort Studies; Diet; DNA Methylation; Female; Humans; Mid

2012
Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.
    Biochemical pharmacology, 2012, Mar-15, Volume: 83, Issue:6

    Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Autophagy; Breast Neoplasms; Caffeine; Capsaicin;

2012
Induction of apoptosis and non-apoptosis in human breast cancer cell line (MCF-7) by cisplatin and caffeine.
    Iranian biomedical journal, 2011, Volume: 15, Issue:4

    Topics: Apoptosis; Breast Neoplasms; Caffeine; Cell Adhesion; Cell Line, Tumor; Cisplatin; DNA, Neoplasm; Fe

2011
The application of nonsense-mediated mRNA decay inhibition to the identification of breast cancer susceptibility genes.
    BMC cancer, 2012, Jun-15, Volume: 12

    Topics: Base Sequence; Breast Neoplasms; Caffeine; Cell Line, Tumor; Family; Female; Gene Expression Profili

2012
Coffee and black tea consumption and breast cancer mortality in a cohort of Swedish women.
    British journal of cancer, 2012, Aug-21, Volume: 107, Issue:5

    Topics: Aged; Beverages; Breast Neoplasms; Caffeine; Coffee; Female; Humans; Incidence; Middle Aged; Prospec

2012
Interaction between CYP1A1 polymorphic variants and dietary exposures influencing ovarian cancer risk.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003, Volume: 12, Issue:3

    Topics: Alleles; Breast Neoplasms; Caffeine; Confidence Intervals; Cytochrome P-450 CYP1A1; Feeding Behavior

2003
Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event.
    Cancer research, 2004, Oct-01, Volume: 64, Issue:19

    Topics: Apoptosis; Breast Neoplasms; Caffeine; Caspase 3; Caspase 9; Caspases; Cell Cycle; Cell Line, Tumor;

2004
CYP1A1 activation of aminoflavone leads to DNA damage in human tumor cell lines.
    Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:5

    Topics: Androstadienes; Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Caffeine; Cell Cycle Prote

2006
Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells.
    Oncogene, 2006, Feb-16, Volume: 25, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caffeine; Carcinoma; Caspase 3; Caspases; Cyclin

2006
Consumption of coffee, but not black tea, is associated with decreased risk of premenopausal breast cancer.
    The Journal of nutrition, 2006, Volume: 136, Issue:1

    Topics: Adult; Aged; Body Mass Index; Breast Neoplasms; Caffeine; Case-Control Studies; Coffee; Female; Huma

2006
gamma-Radiation-induced chromosomal mutagen sensitivity is associated with breast cancer risk in African-American women: caffeine modulates the outcome of mutagen sensitivity assay.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006, Volume: 15, Issue:3

    Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Biomarkers, Tumor; Black or African American; Brea

2006
Health behaviors in breast cancer survivors experiencing bone loss.
    Journal of the American Academy of Nurse Practitioners, 2006, Volume: 18, Issue:10

    Topics: Absorptiometry, Photon; Adult; Aged; Alcohol Drinking; Attitude to Health; Breast Neoplasms; Caffein

2006
The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Volume: 16, Issue:5

    Topics: Adult; Breast Neoplasms; Caffeine; Canada; Case-Control Studies; Coffee; Confidence Intervals; Cytoc

2007
Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-up.
    International journal of cancer, 2008, May-01, Volume: 122, Issue:9

    Topics: Adult; Aged; Body Mass Index; Breast Neoplasms; Caffeine; Central Nervous System Stimulants; Coffee;

2008
Caffeine overcomes genistein-induced G2/M cell cycle arrest in breast cancer cells.
    Nutrition and cancer, 2008, Volume: 60, Issue:3

    Topics: Antineoplastic Agents; Breast Neoplasms; Caffeine; Cell Line, Tumor; Dose-Response Relationship, Dru

2008
Hormone and methylxanthine action on breast epithelial cells.
    Life sciences, 1984, Jun-18, Volume: 34, Issue:25

    Topics: 2-Chloroadenosine; Adenosine; Animals; Breast; Breast Neoplasms; Caffeine; Cell Line; Cyclic AMP; Ep

1984
Epidemiology and risk factors in breast cancer. Can we change the odds?
    The Journal of reproductive medicine, 1982, Volume: 27, Issue:11

    Topics: Adult; Breast Neoplasms; Caffeine; Diet; Female; Fibrocystic Breast Disease; Humans; Middle Aged; Ri

1982
Alcohol, smoking, passive smoking and caffeine in relation to breast cancer risk in young women. UK National Case-Control Study Group.
    British journal of cancer, 1994, Volume: 70, Issue:1

    Topics: Adolescent; Adult; Alcohol Drinking; Breast Neoplasms; Caffeine; Case-Control Studies; Chi-Square Di

1994
No association between caffeine intake and postmenopausal breast cancer incidence in the Iowa Women's Health Study.
    American journal of epidemiology, 1993, Sep-15, Volume: 138, Issue:6

    Topics: Aged; Breast Neoplasms; Caffeine; Chi-Square Distribution; Female; Humans; Incidence; Iowa; Middle A

1993
Nutritional concerns of women with breast cancer.
    Journal of cancer education : the official journal of the American Association for Cancer Education, 1993,Spring, Volume: 8, Issue:1

    Topics: Adult; Aged; Attitude to Health; Body Weight; Breast Neoplasms; Caffeine; Diet; Dietary Fats; Female

1993
Hypothesis: coffee consumption, N-acetyltransferase phenotype, and cancer.
    Journal of the National Cancer Institute, 1993, Jun-16, Volume: 85, Issue:12

    Topics: Acetylation; Arylamine N-Acetyltransferase; Breast Neoplasms; Caffeine; Coffee; Colonic Neoplasms; F

1993
Paclitaxel-induced apoptosis in MCF-7 breast-cancer cells.
    International journal of cancer, 1997, Jan-17, Volume: 70, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasm

1997
Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women.
    Nutrition and cancer, 1998, Volume: 30, Issue:1

    Topics: Adult; Body Mass Index; Breast Neoplasms; Caffeine; Carbonated Beverages; Coffee; Estradiol; Female;

1998
Coffee consumption and the risk of breast cancer.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 1998, Volume: 7, Issue:1

    Topics: Adult; Aged; Breast Neoplasms; Caffeine; Carcinogens; Case-Control Studies; Coffee; Female; Humans;

1998
Common fragile site expression and genetic predisposition to breast cancer.
    Teratogenesis, carcinogenesis, and mutagenesis, 1998, Volume: 18, Issue:6

    Topics: Aphidicolin; Breast Neoplasms; Caffeine; Chromosome Aberrations; Chromosome Fragile Sites; Chromosom

1998
Variation in sensitizing effect of caffeine in human tumour cell lines after gamma-irradiation.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2000, Volume: 54, Issue:3

    Topics: Breast Neoplasms; Caffeine; Cell Cycle; Female; G1 Phase; G2 Phase; Gamma Rays; Humans; Radiation To

2000
Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs.
    International journal of oncology, 2000, Volume: 16, Issue:5

    Topics: Breast Neoplasms; Caffeine; Cobalt Radioisotopes; DNA Damage; DNA Repair; G2 Phase; Humans; Structur

2000
Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells.
    Biochemical and biophysical research communications, 2001, Apr-20, Volume: 282, Issue:5

    Topics: Androstadienes; Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Cadmium Chloride; Caffeine

2001
Coffee, tea, and caffeine consumption and breast cancer incidence in a cohort of Swedish women.
    Annals of epidemiology, 2002, Volume: 12, Issue:1

    Topics: Adult; Aged; Breast Neoplasms; Caffeine; Coffee; Epidemiologic Methods; Female; Humans; Incidence; M

2002
Caffeine eliminates gamma-ray-induced G2-phase delay in human tumor cells but not in normal cells.
    Radiation research, 2002, Volume: 157, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzy

2002
Breast cancer and methylxanthine consumption.
    Cancer causes & control : CCC, 1992, Volume: 3, Issue:2

    Topics: Adult; Aged; Beverages; Breast Neoplasms; Cacao; Caffeine; Candy; Carbonated Beverages; Case-Control

1992
Methylxanthines and breast cancer.
    International journal of cancer, 1987, Oct-15, Volume: 40, Issue:4

    Topics: Adult; Age Factors; Beverages; Breast Neoplasms; Cacao; Caffeine; Diagnosis-Related Groups; Epidemio

1987
Methylxanthines and breast cancer.
    International journal of cancer, 1988, Mar-15, Volume: 41, Issue:3

    Topics: Adult; Aged; Breast Neoplasms; Caffeine; Diet; Female; Humans; Menopause; Middle Aged; Risk Factors;

1988
Patient discomfort during screen-film mammography.
    Radiology, 1988, Volume: 168, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Caffeine; Female; Humans; Mammography; Menstruatio

1988
Can a low-fat diet prevent breast cancer?
    RN, 1987, Volume: 50, Issue:6

    Topics: Breast Neoplasms; Caffeine; Dietary Fats; Female; Humans

1987
Association of tumor differentiation with caffeine and coffee intake in women with breast cancer.
    Surgery, 1986, Volume: 100, Issue:3

    Topics: Breast Neoplasms; Caffeine; Cell Differentiation; Coffee; Female; Humans; Regression Analysis

1986
Coffee and methylxanthines and breast cancer: a case-control study.
    Journal of the National Cancer Institute, 1985, Volume: 74, Issue:3

    Topics: Adult; Breast Neoplasms; Caffeine; Coffee; Dietary Fats; Female; Humans; Middle Aged; Smoking; Xanth

1985
Statistical errors invalidate conclusions in "Caffeine and unsaturated fat diet significantly promotes DMBA-induced breast cancer in rats".
    Cancer, 1985, Apr-15, Volume: 55, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Caffeine; Cocarcinogenesis; Dietary Fat

1985
Breast cancer and the consumption of coffee.
    American journal of epidemiology, 1985, Volume: 122, Issue:3

    Topics: Adult; Age Factors; Aged; Breast Neoplasms; Caffeine; Coffee; Female; Fibrocystic Breast Disease; Hu

1985