caffeine has been researched along with Bradycardia in 34 studies
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methylxanthines and doxapram are currently used to treat apnea of prematurity but are not fully effective and often present undesirable side effects." | 9.11 | Olfactory stimulation prevents apnea in premature newborns. ( Gaugler, C; Marlier, L; Messer, J, 2005) |
| "Fifteen infants, median gestational age at birth 27 weeks (range 24-30), age at study 27 days (12-60), with >/=6 episodes of bradycardia or hypoxaemia/6 h despite serum caffeine levels in the therapeutic range, received doxapram either intravenously (0." | 9.09 | Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants. ( Bohnhorst, B; Darraj, S; Poets, CF, 1999) |
| " Aminophylline (n = 98) and caffeine citrate (n = 82) were equally effective in preventing apnea and bradycardia." | 9.08 | Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates. ( Brendstrup, L; Flachs, H; Larsen, PB; Skov, L, 1995) |
| " Tracings were analyzed for evidence of apnea, periodic breathing, and/or bradycardia by a pulmonologist unaware of the drug given." | 9.06 | High-dose caffeine suppresses postoperative apnea in former preterm infants. ( Fink, R; Hannallah, RS; Hicks, JM; Ruttimann, UE; Welborn, LG, 1989) |
| "Prematurity apnea remains a major clinical problem that requires treatment choices which are sometimes difficult." | 8.86 | [Apnea of prematurity: what's new?]. ( El Ayoubi, M; Lescure, S; Lopez, E; Moriette, G, 2010) |
| " Second, we recommend the use of intravenous caffeine base 10 mg/kg in all infants at risk for postoperative apnea following general anesthesia." | 8.79 | Anesthesia and apnea. Perioperative considerations in the former preterm infant. ( Greenspun, JC; Welborn, LG, 1994) |
| "Apnea of prematurity affects a small proportion but large absolute number of late preterm infants, with out-patient management variably utilized despite relative clinical equipoise and potential for improved cost-effectiveness." | 7.85 | Economics of Home Monitoring for Apnea in Late Preterm Infants. ( Amberson, M; Dukhovny, D; Freiberger, C; Montenegro, BL; Rhein, LM; Veit, L, 2017) |
| "Apnea is nearly universal among very low birth weight (VLBW) infants, and the associated bradycardia and desaturation may have detrimental consequences." | 7.81 | Very long apnea events in preterm infants. ( Clark, MT; Delos, JB; Fairchild, KD; Kattwinkel, J; Lake, DE; Lee, H; Mennen, AC; Mohr, MA; Moorman, JR; Sinkin, RA; Vergales, BD, 2015) |
| "Apnea can occur when spinal anaesthesia is used as the sole anaesthetic technique in the former pre-term infant." | 7.70 | Apnea following spinal anaesthesia in two former pre-term infants. ( Burd, RS; Helikson, MA; Tobias, JD, 1998) |
| " Comparison of the groups using quantitative measures of apnea, bradycardia, and periodic breathing obtained from pneumogram analysis and the incidence of monitor alarms on bedside nursing records showed no significant differences." | 7.67 | Transplacentally acquired caffeine and the occurrence of apnea, bradycardia, and periodic breathing in preterm infants: preliminary communication. ( Braun, RJ; Evans, MA; Kelly, DH; McCulloch, KM; Simms, PE, 1989) |
| "This review provides an understanding of current problems related to apnea of infancy." | 7.67 | Infant apnea. ( Fox, WW; Spitzer, AR, 1986) |
| "The efficacy of low and high dose caffeine on idiopathic bradycardia and hypoxaemia was tested in premature infants." | 7.67 | [Effectiveness of low- and high-dose caffeine on idiopathic bradycardia and hypoxemia in premature infants]. ( Bucher, HU; Duc, G; Fallenstein, F; Mieth, D, 1985) |
| "Methylxanthines and doxapram are currently used to treat apnea of prematurity but are not fully effective and often present undesirable side effects." | 5.11 | Olfactory stimulation prevents apnea in premature newborns. ( Gaugler, C; Marlier, L; Messer, J, 2005) |
| "Fifteen infants, median gestational age at birth 27 weeks (range 24-30), age at study 27 days (12-60), with >/=6 episodes of bradycardia or hypoxaemia/6 h despite serum caffeine levels in the therapeutic range, received doxapram either intravenously (0." | 5.09 | Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants. ( Bohnhorst, B; Darraj, S; Poets, CF, 1999) |
| " Aminophylline (n = 98) and caffeine citrate (n = 82) were equally effective in preventing apnea and bradycardia." | 5.08 | Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates. ( Brendstrup, L; Flachs, H; Larsen, PB; Skov, L, 1995) |
| " Tracings were analyzed for evidence of apnea, periodic breathing, and/or bradycardia by a pulmonologist unaware of the drug given." | 5.06 | High-dose caffeine suppresses postoperative apnea in former preterm infants. ( Fink, R; Hannallah, RS; Hicks, JM; Ruttimann, UE; Welborn, LG, 1989) |
| " Despite aggressive respiratory support including mechanical ventilation, continuous positive airway pressure, oxygen and caffeine therapy to reduce apnea and accompanying intermittent hypoxemia, the incidence of intermittent hypoxemia events continues to increase during the first few months of life." | 4.93 | Cardiorespiratory events in preterm infants: interventions and consequences. ( Di Fiore, JM; Gauda, E; MacFarlane, P; Martin, RJ; Poets, CF, 2016) |
| "Prematurity apnea remains a major clinical problem that requires treatment choices which are sometimes difficult." | 4.86 | [Apnea of prematurity: what's new?]. ( El Ayoubi, M; Lescure, S; Lopez, E; Moriette, G, 2010) |
| " Second, we recommend the use of intravenous caffeine base 10 mg/kg in all infants at risk for postoperative apnea following general anesthesia." | 4.79 | Anesthesia and apnea. Perioperative considerations in the former preterm infant. ( Greenspun, JC; Welborn, LG, 1994) |
| "Apnea of prematurity affects a small proportion but large absolute number of late preterm infants, with out-patient management variably utilized despite relative clinical equipoise and potential for improved cost-effectiveness." | 3.85 | Economics of Home Monitoring for Apnea in Late Preterm Infants. ( Amberson, M; Dukhovny, D; Freiberger, C; Montenegro, BL; Rhein, LM; Veit, L, 2017) |
| " Caffeine is frequently used for apnea of prematurity." | 3.83 | Atrial arrhythmia after newborn eye exam, to caffeine or not to caffeine? ( Ahmad, A; Klein, B; Mondal, T, 2016) |
| "Apnea is nearly universal among very low birth weight (VLBW) infants, and the associated bradycardia and desaturation may have detrimental consequences." | 3.81 | Very long apnea events in preterm infants. ( Clark, MT; Delos, JB; Fairchild, KD; Kattwinkel, J; Lake, DE; Lee, H; Mennen, AC; Mohr, MA; Moorman, JR; Sinkin, RA; Vergales, BD, 2015) |
| "Current knowledge suggests that laryngeal chemoreflexes (LCR) are involved in the occurrence of certain neonatal apneas/bradycardias, especially in the preterm newborn." | 3.79 | Effects of caffeine and/or nasal CPAP treatment on laryngeal chemoreflexes in preterm lambs. ( Bairam, A; Boudaa, N; Carrière, V; Germim, PS; Pasquier, JC; Praud, JP; Samson, N, 2013) |
| " Injection of CGS-21680HCl (CGS; 20 nmol), an adenosine A(2A) receptor agonist, elicited a decrease of arterial BP and HR, while injection of 8-(3-Chlorostyryl)caffeine (CSC; 10 nmol), an adenosine A(2A) receptor antagonist, blocked the depressor and bradycardiac effects of CGS (20 nmol)." | 3.75 | Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats. ( Koh, HC; Lee, CB, 2009) |
| "Apnea can occur when spinal anaesthesia is used as the sole anaesthetic technique in the former pre-term infant." | 3.70 | Apnea following spinal anaesthesia in two former pre-term infants. ( Burd, RS; Helikson, MA; Tobias, JD, 1998) |
| "The treatment of neonatal apnea and bradycardia with methylated xanthines--theophylline and caffeine--is generally accepted." | 3.68 | [Effect of methylxanthines on periodic respiration and acid gastroesophageal reflux in newborn infants]. ( Heimann, G; Koch, G; Skopnik, H, 1990) |
| " Comparison of the groups using quantitative measures of apnea, bradycardia, and periodic breathing obtained from pneumogram analysis and the incidence of monitor alarms on bedside nursing records showed no significant differences." | 3.67 | Transplacentally acquired caffeine and the occurrence of apnea, bradycardia, and periodic breathing in preterm infants: preliminary communication. ( Braun, RJ; Evans, MA; Kelly, DH; McCulloch, KM; Simms, PE, 1989) |
| "This review provides an understanding of current problems related to apnea of infancy." | 3.67 | Infant apnea. ( Fox, WW; Spitzer, AR, 1986) |
| "The efficacy of low and high dose caffeine on idiopathic bradycardia and hypoxaemia was tested in premature infants." | 3.67 | [Effectiveness of low- and high-dose caffeine on idiopathic bradycardia and hypoxemia in premature infants]. ( Bucher, HU; Duc, G; Fallenstein, F; Mieth, D, 1985) |
| "· Identification of risk factors for central apnea can lead to improved treatment protocols." | 1.62 | Central Apnea of Prematurity: Does Sex Matter? ( Fairchild, KD; Kuhn, L; Lake, DE; Moorman, JR; Nagraj, VP, 2021) |
| "Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by mutations in cardiac ryanodine receptor (RyR2) or calsequestrin (Casq2) genes." | 1.39 | Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients. ( Faggioni, M; Hwang, HS; Kannankeril, PJ; Knollmann, BC; Nederend, I; van der Werf, C; Wilde, AA, 2013) |
| "Caffeine was present in the serum of six infants, and three of the six infants had caffeine in their urine." | 1.27 | Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine. ( Altman, RE; Kanto, WP; McGowan, JD, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (32.35) | 18.7374 |
| 1990's | 8 (23.53) | 18.2507 |
| 2000's | 4 (11.76) | 29.6817 |
| 2010's | 10 (29.41) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Nagraj, VP | 1 |
| Lake, DE | 2 |
| Kuhn, L | 1 |
| Moorman, JR | 2 |
| Fairchild, KD | 2 |
| Kumar, M | 1 |
| Chawla, R | 1 |
| Haloi, P | 1 |
| Singh, M | 1 |
| Mohr, MA | 1 |
| Vergales, BD | 1 |
| Lee, H | 1 |
| Clark, MT | 1 |
| Mennen, AC | 1 |
| Kattwinkel, J | 1 |
| Sinkin, RA | 1 |
| Delos, JB | 1 |
| Di Fiore, JM | 1 |
| Poets, CF | 2 |
| Gauda, E | 1 |
| Martin, RJ | 1 |
| MacFarlane, P | 1 |
| Montenegro, BL | 1 |
| Amberson, M | 1 |
| Veit, L | 1 |
| Freiberger, C | 1 |
| Dukhovny, D | 1 |
| Rhein, LM | 1 |
| Ahmad, A | 1 |
| Mondal, T | 1 |
| Klein, B | 1 |
| Mancarella, S | 1 |
| Yue, Y | 1 |
| Karnabi, E | 1 |
| Qu, Y | 1 |
| El-Sherif, N | 1 |
| Boutjdir, M | 1 |
| Lee, CB | 1 |
| Koh, HC | 1 |
| Moriette, G | 1 |
| Lescure, S | 1 |
| El Ayoubi, M | 1 |
| Lopez, E | 1 |
| Henderson-Smart, DJ | 1 |
| De Paoli, AG | 1 |
| LaRue, S | 1 |
| Shanks, A | 1 |
| Wang, IW | 1 |
| Ewald, G | 1 |
| Anderson, D | 1 |
| Joseph, S | 1 |
| Faggioni, M | 1 |
| Hwang, HS | 1 |
| van der Werf, C | 1 |
| Nederend, I | 1 |
| Kannankeril, PJ | 1 |
| Wilde, AA | 1 |
| Knollmann, BC | 1 |
| Boudaa, N | 1 |
| Samson, N | 1 |
| Carrière, V | 1 |
| Germim, PS | 1 |
| Pasquier, JC | 1 |
| Bairam, A | 1 |
| Praud, JP | 1 |
| Marlier, L | 1 |
| Gaugler, C | 1 |
| Messer, J | 1 |
| Vermeylen, D | 1 |
| Franco, P | 1 |
| Hennequin, Y | 1 |
| Pardou, A | 1 |
| Brugmans, M | 1 |
| Simon, P | 1 |
| Hassid, S | 1 |
| Haley, TJ | 1 |
| Larsen, PB | 1 |
| Brendstrup, L | 1 |
| Skov, L | 1 |
| Flachs, H | 1 |
| Welborn, LG | 2 |
| Greenspun, JC | 1 |
| Duc, G | 3 |
| Bucher, HU | 3 |
| Tobias, JD | 1 |
| Burd, RS | 1 |
| Helikson, MA | 1 |
| du Preez, MJ | 1 |
| Botha, JH | 1 |
| McFadyen, ML | 1 |
| Adhikari, M | 1 |
| Darraj, S | 1 |
| Bohnhorst, B | 1 |
| Lucey, JF | 1 |
| Toubas, PL | 1 |
| Sekar, KC | 1 |
| Sheldon, RE | 1 |
| Seale, TW | 1 |
| Skopnik, H | 1 |
| Koch, G | 1 |
| Heimann, G | 1 |
| Hannallah, RS | 1 |
| Fink, R | 1 |
| Ruttimann, UE | 1 |
| Hicks, JM | 1 |
| Fuglsang, G | 1 |
| Nielsen, K | 1 |
| Kjaer Nielsen, L | 1 |
| Sennels, F | 1 |
| Jakobsen, P | 1 |
| Thelle, T | 1 |
| McCulloch, KM | 1 |
| Braun, RJ | 1 |
| Simms, PE | 1 |
| Evans, MA | 1 |
| Kelly, DH | 1 |
| McGowan, JD | 1 |
| Altman, RE | 1 |
| Kanto, WP | 1 |
| Spitzer, AR | 1 |
| Fox, WW | 1 |
| Fallenstein, F | 1 |
| Mieth, D | 1 |
| Hartl, O | 1 |
| Clodi, PH | 1 |
| Schaumann, W | 1 |
| Juhran, W | 1 |
| Dietmann, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU[NCT05451953] | 110 participants (Anticipated) | Interventional | 2022-07-21 | Recruiting | |||
| [NCT01066728] | Phase 2/Phase 3 | 87 participants (Actual) | Interventional | 2001-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for caffeine and Bradycardia
| Article | Year |
|---|---|
Cardiorespiratory events in preterm infants: interventions and consequences.
Topics: Animals; Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Continuous Positive Airway | 2016 |
[Apnea of prematurity: what's new?].
Topics: Apnea; Bradycardia; Brain Damage, Chronic; Bronchopulmonary Dysplasia; Caffeine; Central Nervous Sys | 2010 |
Prophylactic methylxanthine for prevention of apnoea in preterm infants.
Topics: Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Humans; Hypoxia; Infant, Newborn; I | 2010 |
Metabolism and pharmacokinetics of theophylline in human neonates, children, and adults.
Topics: Adult; Age Factors; Apnea; Asthma; Biotransformation; Bradycardia; Caffeine; Child; Female; Half-Lif | 1983 |
Anesthesia and apnea. Perioperative considerations in the former preterm infant.
Topics: Age Factors; Anemia; Anesthesia; Apnea; Bradycardia; Caffeine; Clinical Protocols; Gestational Age; | 1994 |
7 trials available for caffeine and Bradycardia
| Article | Year |
|---|---|
Olfactory stimulation prevents apnea in premature newborns.
Topics: Apnea; Aromatherapy; Bradycardia; Caffeine; Central Nervous System Stimulants; Combined Modality The | 2005 |
Laryngeal oedema in neonatal apnoea and bradycardia syndrome (a pilot study).
Topics: Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Bradycardia; Caffeine; De | 2005 |
Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates.
Topics: Apnea; Bradycardia; Caffeine; Citrates; Drug Combinations; Humans; Infant, Newborn; Infant, Prematur | 1995 |
Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants.
Topics: Apnea; Birth Weight; Bradycardia; Caffeine; Doxapram; Drug Resistance; Gestational Age; Humans; Hypo | 1999 |
High-dose caffeine suppresses postoperative apnea in former preterm infants.
Topics: Anesthesia, General; Apnea; Bradycardia; Caffeine; Clinical Trials as Topic; Double-Blind Method; He | 1989 |
The effect of caffeine compared with theophylline in the treatment of idiopathic apnea in premature infants.
Topics: Administration, Oral; Apnea; Bradycardia; Caffeine; Clinical Trials as Topic; Double-Blind Method; F | 1989 |
Does caffeine prevent hypoxaemic episodes in premature infants? A randomized controlled trial.
Topics: Blood Gas Monitoring, Transcutaneous; Bradycardia; Caffeine; Citrates; Clinical Trials as Topic; Dou | 1988 |
22 other studies available for caffeine and Bradycardia
| Article | Year |
|---|---|
Central Apnea of Prematurity: Does Sex Matter?
Topics: Bradycardia; Caffeine; Cohort Studies; Female; Gestational Age; Humans; Infant, Newborn; Infant, Pre | 2021 |
The use of caffeine for the treatment of apnea of prematurity and bradycardia in a holoprosencephalic child with cleft lip and palate.
Topics: Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Citrates; Cleft Lip; Cleft Palate; | 2013 |
Very long apnea events in preterm infants.
Topics: Apnea; Bradycardia; Caffeine; Continuous Positive Airway Pressure; Female; Heart Rate; Humans; Infan | 2015 |
Economics of Home Monitoring for Apnea in Late Preterm Infants.
Topics: Ambulatory Care; Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Cost Savings; Gest | 2017 |
Atrial arrhythmia after newborn eye exam, to caffeine or not to caffeine?
Topics: Apnea; Atrial Premature Complexes; Bradycardia; Caffeine; Central Nervous System Stimulants; Cyclope | 2016 |
Impaired Ca2+ homeostasis is associated with atrial fibrillation in the alpha1D L-type Ca2+ channel KO mouse.
Topics: Action Potentials; Animals; Atrial Fibrillation; Atrioventricular Block; Bradycardia; Caffeine; Calc | 2008 |
Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenylyl Cyclase Inhib | 2009 |
Left ventricular assist device in pregnancy.
Topics: Adolescent; Anticoagulants; Betamethasone; Bradycardia; Caffeine; Cardiomyopathies; Cesarean Section | 2011 |
Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients.
Topics: Adult; Animals; Atropine; Bradycardia; Caffeine; Calcium Signaling; Calsequestrin; Cardiac Pacing, A | 2013 |
Effects of caffeine and/or nasal CPAP treatment on laryngeal chemoreflexes in preterm lambs.
Topics: Animals; Animals, Newborn; Apnea; Arterial Pressure; Bradycardia; Caffeine; Continuous Positive Airw | 2013 |
Aminophylline versus caffeine citrate...
Topics: Aminophylline; Apnea; Bradycardia; Caffeine; Cardiotonic Agents; Citrates; Clinical Trials as Topic; | 1995 |
Apnea following spinal anaesthesia in two former pre-term infants.
Topics: Age Factors; Anesthesia, Spinal; Anesthetics, Local; Apnea; Benzoates; Bradycardia; Caffeine; Centra | 1998 |
The effect of theophylline on apnoea and hypoxaemic episodes in the premature neonate during the 1st 3 days after birth.
Topics: Apnea; Blood Pressure; Bradycardia; Bronchodilator Agents; Caffeine; Female; Gestational Age; Humans | 1998 |
The xanthine treatment of apnea of prematurity.
Topics: Aminophylline; Apnea; Bradycardia; Caffeine; Humans; Hypoxia; Infant, Newborn; Infant, Premature, Di | 1975 |
Fetal and newborn lambs differ in their cardiopulmonary responsiveness to adenosine agonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Animals, Newborn; Blood Pressure; Bradycardia | 1990 |
[Effect of methylxanthines on periodic respiration and acid gastroesophageal reflux in newborn infants].
Topics: Bradycardia; Caffeine; Citrates; Drug Combinations; Drug Therapy, Combination; Gastric Acidity Deter | 1990 |
Transplacentally acquired caffeine and the occurrence of apnea, bradycardia, and periodic breathing in preterm infants: preliminary communication.
Topics: Apnea; Bradycardia; Caffeine; Cheyne-Stokes Respiration; Chromatography, High Pressure Liquid; Femal | 1989 |
Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine.
Topics: Bradycardia; Caffeine; Female; Humans; Infant, Newborn; Male; Neonatal Abstinence Syndrome; Respirat | 1988 |
Infant apnea.
Topics: Airway Obstruction; Apnea; Bradycardia; Caffeine; Cardiography, Impedance; Home Nursing; Humans; Inf | 1986 |
[Effectiveness of low- and high-dose caffeine on idiopathic bradycardia and hypoxemia in premature infants].
Topics: Bradycardia; Caffeine; Citrates; Dose-Response Relationship, Drug; Drug Combinations; Humans; Hypoxi | 1985 |
[Therapy of arrhythmias].
Topics: Ajmaline; Arrhythmias, Cardiac; Atrial Fibrillation; Bradycardia; Caffeine; Cardiac Complexes, Prema | 1973 |
[Antagonism of circulation effect of adenosine by theophylline].
Topics: Adenine Nucleotides; Aminophylline; Animals; Arteries; Blood Circulation; Blood Platelets; Blood Pre | 1970 |