Page last updated: 2024-10-24

caffeine and Bradycardia

caffeine has been researched along with Bradycardia in 34 studies

Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.

Research Excerpts

ExcerptRelevanceReference
"Methylxanthines and doxapram are currently used to treat apnea of prematurity but are not fully effective and often present undesirable side effects."9.11Olfactory stimulation prevents apnea in premature newborns. ( Gaugler, C; Marlier, L; Messer, J, 2005)
"Fifteen infants, median gestational age at birth 27 weeks (range 24-30), age at study 27 days (12-60), with >/=6 episodes of bradycardia or hypoxaemia/6 h despite serum caffeine levels in the therapeutic range, received doxapram either intravenously (0."9.09Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants. ( Bohnhorst, B; Darraj, S; Poets, CF, 1999)
" Aminophylline (n = 98) and caffeine citrate (n = 82) were equally effective in preventing apnea and bradycardia."9.08Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates. ( Brendstrup, L; Flachs, H; Larsen, PB; Skov, L, 1995)
" Tracings were analyzed for evidence of apnea, periodic breathing, and/or bradycardia by a pulmonologist unaware of the drug given."9.06High-dose caffeine suppresses postoperative apnea in former preterm infants. ( Fink, R; Hannallah, RS; Hicks, JM; Ruttimann, UE; Welborn, LG, 1989)
"Prematurity apnea remains a major clinical problem that requires treatment choices which are sometimes difficult."8.86[Apnea of prematurity: what's new?]. ( El Ayoubi, M; Lescure, S; Lopez, E; Moriette, G, 2010)
" Second, we recommend the use of intravenous caffeine base 10 mg/kg in all infants at risk for postoperative apnea following general anesthesia."8.79Anesthesia and apnea. Perioperative considerations in the former preterm infant. ( Greenspun, JC; Welborn, LG, 1994)
"Apnea of prematurity affects a small proportion but large absolute number of late preterm infants, with out-patient management variably utilized despite relative clinical equipoise and potential for improved cost-effectiveness."7.85Economics of Home Monitoring for Apnea in Late Preterm Infants. ( Amberson, M; Dukhovny, D; Freiberger, C; Montenegro, BL; Rhein, LM; Veit, L, 2017)
"Apnea is nearly universal among very low birth weight (VLBW) infants, and the associated bradycardia and desaturation may have detrimental consequences."7.81Very long apnea events in preterm infants. ( Clark, MT; Delos, JB; Fairchild, KD; Kattwinkel, J; Lake, DE; Lee, H; Mennen, AC; Mohr, MA; Moorman, JR; Sinkin, RA; Vergales, BD, 2015)
"Apnea can occur when spinal anaesthesia is used as the sole anaesthetic technique in the former pre-term infant."7.70Apnea following spinal anaesthesia in two former pre-term infants. ( Burd, RS; Helikson, MA; Tobias, JD, 1998)
" Comparison of the groups using quantitative measures of apnea, bradycardia, and periodic breathing obtained from pneumogram analysis and the incidence of monitor alarms on bedside nursing records showed no significant differences."7.67Transplacentally acquired caffeine and the occurrence of apnea, bradycardia, and periodic breathing in preterm infants: preliminary communication. ( Braun, RJ; Evans, MA; Kelly, DH; McCulloch, KM; Simms, PE, 1989)
"This review provides an understanding of current problems related to apnea of infancy."7.67Infant apnea. ( Fox, WW; Spitzer, AR, 1986)
"The efficacy of low and high dose caffeine on idiopathic bradycardia and hypoxaemia was tested in premature infants."7.67[Effectiveness of low- and high-dose caffeine on idiopathic bradycardia and hypoxemia in premature infants]. ( Bucher, HU; Duc, G; Fallenstein, F; Mieth, D, 1985)
"Methylxanthines and doxapram are currently used to treat apnea of prematurity but are not fully effective and often present undesirable side effects."5.11Olfactory stimulation prevents apnea in premature newborns. ( Gaugler, C; Marlier, L; Messer, J, 2005)
"Fifteen infants, median gestational age at birth 27 weeks (range 24-30), age at study 27 days (12-60), with >/=6 episodes of bradycardia or hypoxaemia/6 h despite serum caffeine levels in the therapeutic range, received doxapram either intravenously (0."5.09Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants. ( Bohnhorst, B; Darraj, S; Poets, CF, 1999)
" Aminophylline (n = 98) and caffeine citrate (n = 82) were equally effective in preventing apnea and bradycardia."5.08Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates. ( Brendstrup, L; Flachs, H; Larsen, PB; Skov, L, 1995)
" Tracings were analyzed for evidence of apnea, periodic breathing, and/or bradycardia by a pulmonologist unaware of the drug given."5.06High-dose caffeine suppresses postoperative apnea in former preterm infants. ( Fink, R; Hannallah, RS; Hicks, JM; Ruttimann, UE; Welborn, LG, 1989)
" Despite aggressive respiratory support including mechanical ventilation, continuous positive airway pressure, oxygen and caffeine therapy to reduce apnea and accompanying intermittent hypoxemia, the incidence of intermittent hypoxemia events continues to increase during the first few months of life."4.93Cardiorespiratory events in preterm infants: interventions and consequences. ( Di Fiore, JM; Gauda, E; MacFarlane, P; Martin, RJ; Poets, CF, 2016)
"Prematurity apnea remains a major clinical problem that requires treatment choices which are sometimes difficult."4.86[Apnea of prematurity: what's new?]. ( El Ayoubi, M; Lescure, S; Lopez, E; Moriette, G, 2010)
" Second, we recommend the use of intravenous caffeine base 10 mg/kg in all infants at risk for postoperative apnea following general anesthesia."4.79Anesthesia and apnea. Perioperative considerations in the former preterm infant. ( Greenspun, JC; Welborn, LG, 1994)
"Apnea of prematurity affects a small proportion but large absolute number of late preterm infants, with out-patient management variably utilized despite relative clinical equipoise and potential for improved cost-effectiveness."3.85Economics of Home Monitoring for Apnea in Late Preterm Infants. ( Amberson, M; Dukhovny, D; Freiberger, C; Montenegro, BL; Rhein, LM; Veit, L, 2017)
" Caffeine is frequently used for apnea of prematurity."3.83Atrial arrhythmia after newborn eye exam, to caffeine or not to caffeine? ( Ahmad, A; Klein, B; Mondal, T, 2016)
"Apnea is nearly universal among very low birth weight (VLBW) infants, and the associated bradycardia and desaturation may have detrimental consequences."3.81Very long apnea events in preterm infants. ( Clark, MT; Delos, JB; Fairchild, KD; Kattwinkel, J; Lake, DE; Lee, H; Mennen, AC; Mohr, MA; Moorman, JR; Sinkin, RA; Vergales, BD, 2015)
"Current knowledge suggests that laryngeal chemoreflexes (LCR) are involved in the occurrence of certain neonatal apneas/bradycardias, especially in the preterm newborn."3.79Effects of caffeine and/or nasal CPAP treatment on laryngeal chemoreflexes in preterm lambs. ( Bairam, A; Boudaa, N; Carrière, V; Germim, PS; Pasquier, JC; Praud, JP; Samson, N, 2013)
" Injection of CGS-21680HCl (CGS; 20 nmol), an adenosine A(2A) receptor agonist, elicited a decrease of arterial BP and HR, while injection of 8-(3-Chlorostyryl)caffeine (CSC; 10 nmol), an adenosine A(2A) receptor antagonist, blocked the depressor and bradycardiac effects of CGS (20 nmol)."3.75Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats. ( Koh, HC; Lee, CB, 2009)
"Apnea can occur when spinal anaesthesia is used as the sole anaesthetic technique in the former pre-term infant."3.70Apnea following spinal anaesthesia in two former pre-term infants. ( Burd, RS; Helikson, MA; Tobias, JD, 1998)
"The treatment of neonatal apnea and bradycardia with methylated xanthines--theophylline and caffeine--is generally accepted."3.68[Effect of methylxanthines on periodic respiration and acid gastroesophageal reflux in newborn infants]. ( Heimann, G; Koch, G; Skopnik, H, 1990)
" Comparison of the groups using quantitative measures of apnea, bradycardia, and periodic breathing obtained from pneumogram analysis and the incidence of monitor alarms on bedside nursing records showed no significant differences."3.67Transplacentally acquired caffeine and the occurrence of apnea, bradycardia, and periodic breathing in preterm infants: preliminary communication. ( Braun, RJ; Evans, MA; Kelly, DH; McCulloch, KM; Simms, PE, 1989)
"This review provides an understanding of current problems related to apnea of infancy."3.67Infant apnea. ( Fox, WW; Spitzer, AR, 1986)
"The efficacy of low and high dose caffeine on idiopathic bradycardia and hypoxaemia was tested in premature infants."3.67[Effectiveness of low- and high-dose caffeine on idiopathic bradycardia and hypoxemia in premature infants]. ( Bucher, HU; Duc, G; Fallenstein, F; Mieth, D, 1985)
"· Identification of risk factors for central apnea can lead to improved treatment protocols."1.62Central Apnea of Prematurity: Does Sex Matter? ( Fairchild, KD; Kuhn, L; Lake, DE; Moorman, JR; Nagraj, VP, 2021)
"Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by mutations in cardiac ryanodine receptor (RyR2) or calsequestrin (Casq2) genes."1.39Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients. ( Faggioni, M; Hwang, HS; Kannankeril, PJ; Knollmann, BC; Nederend, I; van der Werf, C; Wilde, AA, 2013)
"Caffeine was present in the serum of six infants, and three of the six infants had caffeine in their urine."1.27Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine. ( Altman, RE; Kanto, WP; McGowan, JD, 1988)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199011 (32.35)18.7374
1990's8 (23.53)18.2507
2000's4 (11.76)29.6817
2010's10 (29.41)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Nagraj, VP1
Lake, DE2
Kuhn, L1
Moorman, JR2
Fairchild, KD2
Kumar, M1
Chawla, R1
Haloi, P1
Singh, M1
Mohr, MA1
Vergales, BD1
Lee, H1
Clark, MT1
Mennen, AC1
Kattwinkel, J1
Sinkin, RA1
Delos, JB1
Di Fiore, JM1
Poets, CF2
Gauda, E1
Martin, RJ1
MacFarlane, P1
Montenegro, BL1
Amberson, M1
Veit, L1
Freiberger, C1
Dukhovny, D1
Rhein, LM1
Ahmad, A1
Mondal, T1
Klein, B1
Mancarella, S1
Yue, Y1
Karnabi, E1
Qu, Y1
El-Sherif, N1
Boutjdir, M1
Lee, CB1
Koh, HC1
Moriette, G1
Lescure, S1
El Ayoubi, M1
Lopez, E1
Henderson-Smart, DJ1
De Paoli, AG1
LaRue, S1
Shanks, A1
Wang, IW1
Ewald, G1
Anderson, D1
Joseph, S1
Faggioni, M1
Hwang, HS1
van der Werf, C1
Nederend, I1
Kannankeril, PJ1
Wilde, AA1
Knollmann, BC1
Boudaa, N1
Samson, N1
Carrière, V1
Germim, PS1
Pasquier, JC1
Bairam, A1
Praud, JP1
Marlier, L1
Gaugler, C1
Messer, J1
Vermeylen, D1
Franco, P1
Hennequin, Y1
Pardou, A1
Brugmans, M1
Simon, P1
Hassid, S1
Haley, TJ1
Larsen, PB1
Brendstrup, L1
Skov, L1
Flachs, H1
Welborn, LG2
Greenspun, JC1
Duc, G3
Bucher, HU3
Tobias, JD1
Burd, RS1
Helikson, MA1
du Preez, MJ1
Botha, JH1
McFadyen, ML1
Adhikari, M1
Darraj, S1
Bohnhorst, B1
Lucey, JF1
Toubas, PL1
Sekar, KC1
Sheldon, RE1
Seale, TW1
Skopnik, H1
Koch, G1
Heimann, G1
Hannallah, RS1
Fink, R1
Ruttimann, UE1
Hicks, JM1
Fuglsang, G1
Nielsen, K1
Kjaer Nielsen, L1
Sennels, F1
Jakobsen, P1
Thelle, T1
McCulloch, KM1
Braun, RJ1
Simms, PE1
Evans, MA1
Kelly, DH1
McGowan, JD1
Altman, RE1
Kanto, WP1
Spitzer, AR1
Fox, WW1
Fallenstein, F1
Mieth, D1
Hartl, O1
Clodi, PH1
Schaumann, W1
Juhran, W1
Dietmann, K1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU[NCT05451953]110 participants (Anticipated)Interventional2022-07-21Recruiting
[NCT01066728]Phase 2/Phase 387 participants (Actual)Interventional2001-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for caffeine and Bradycardia

ArticleYear
Cardiorespiratory events in preterm infants: interventions and consequences.
    Journal of perinatology : official journal of the California Perinatal Association, 2016, Volume: 36, Issue:4

    Topics: Animals; Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Continuous Positive Airway

2016
[Apnea of prematurity: what's new?].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2010, Volume: 17, Issue:2

    Topics: Apnea; Bradycardia; Brain Damage, Chronic; Bronchopulmonary Dysplasia; Caffeine; Central Nervous Sys

2010
Prophylactic methylxanthine for prevention of apnoea in preterm infants.
    The Cochrane database of systematic reviews, 2010, Dec-08, Issue:12

    Topics: Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Humans; Hypoxia; Infant, Newborn; I

2010
Metabolism and pharmacokinetics of theophylline in human neonates, children, and adults.
    Drug metabolism reviews, 1983, Volume: 14, Issue:2

    Topics: Adult; Age Factors; Apnea; Asthma; Biotransformation; Bradycardia; Caffeine; Child; Female; Half-Lif

1983
Anesthesia and apnea. Perioperative considerations in the former preterm infant.
    Pediatric clinics of North America, 1994, Volume: 41, Issue:1

    Topics: Age Factors; Anemia; Anesthesia; Apnea; Bradycardia; Caffeine; Clinical Protocols; Gestational Age;

1994

Trials

7 trials available for caffeine and Bradycardia

ArticleYear
Olfactory stimulation prevents apnea in premature newborns.
    Pediatrics, 2005, Volume: 115, Issue:1

    Topics: Apnea; Aromatherapy; Bradycardia; Caffeine; Central Nervous System Stimulants; Combined Modality The

2005
Laryngeal oedema in neonatal apnoea and bradycardia syndrome (a pilot study).
    Early human development, 2005, Volume: 81, Issue:4

    Topics: Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Bradycardia; Caffeine; De

2005
Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates.
    Acta paediatrica (Oslo, Norway : 1992), 1995, Volume: 84, Issue:4

    Topics: Apnea; Bradycardia; Caffeine; Citrates; Drug Combinations; Humans; Infant, Newborn; Infant, Prematur

1995
Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants.
    Biology of the neonate, 1999, Volume: 76, Issue:4

    Topics: Apnea; Birth Weight; Bradycardia; Caffeine; Doxapram; Drug Resistance; Gestational Age; Humans; Hypo

1999
High-dose caffeine suppresses postoperative apnea in former preterm infants.
    Anesthesiology, 1989, Volume: 71, Issue:3

    Topics: Anesthesia, General; Apnea; Bradycardia; Caffeine; Clinical Trials as Topic; Double-Blind Method; He

1989
The effect of caffeine compared with theophylline in the treatment of idiopathic apnea in premature infants.
    Acta paediatrica Scandinavica, 1989, Volume: 78, Issue:5

    Topics: Administration, Oral; Apnea; Bradycardia; Caffeine; Clinical Trials as Topic; Double-Blind Method; F

1989
Does caffeine prevent hypoxaemic episodes in premature infants? A randomized controlled trial.
    European journal of pediatrics, 1988, Volume: 147, Issue:3

    Topics: Blood Gas Monitoring, Transcutaneous; Bradycardia; Caffeine; Citrates; Clinical Trials as Topic; Dou

1988

Other Studies

22 other studies available for caffeine and Bradycardia

ArticleYear
Central Apnea of Prematurity: Does Sex Matter?
    American journal of perinatology, 2021, Volume: 38, Issue:13

    Topics: Bradycardia; Caffeine; Cohort Studies; Female; Gestational Age; Humans; Infant, Newborn; Infant, Pre

2021
The use of caffeine for the treatment of apnea of prematurity and bradycardia in a holoprosencephalic child with cleft lip and palate.
    Journal of clinical anesthesia, 2013, Volume: 25, Issue:8

    Topics: Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Citrates; Cleft Lip; Cleft Palate;

2013
Very long apnea events in preterm infants.
    Journal of applied physiology (Bethesda, Md. : 1985), 2015, Mar-01, Volume: 118, Issue:5

    Topics: Apnea; Bradycardia; Caffeine; Continuous Positive Airway Pressure; Female; Heart Rate; Humans; Infan

2015
Economics of Home Monitoring for Apnea in Late Preterm Infants.
    Respiratory care, 2017, Volume: 62, Issue:1

    Topics: Ambulatory Care; Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Cost Savings; Gest

2017
Atrial arrhythmia after newborn eye exam, to caffeine or not to caffeine?
    Journal of neonatal-perinatal medicine, 2016, Volume: 9, Issue:4

    Topics: Apnea; Atrial Premature Complexes; Bradycardia; Caffeine; Central Nervous System Stimulants; Cyclope

2016
Impaired Ca2+ homeostasis is associated with atrial fibrillation in the alpha1D L-type Ca2+ channel KO mouse.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:5

    Topics: Action Potentials; Animals; Atrial Fibrillation; Atrioventricular Block; Bradycardia; Caffeine; Calc

2008
Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats.
    Autonomic neuroscience : basic & clinical, 2009, Mar-12, Volume: 146, Issue:1-2

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenylyl Cyclase Inhib

2009
Left ventricular assist device in pregnancy.
    Obstetrics and gynecology, 2011, Volume: 118, Issue:2 Pt 2

    Topics: Adolescent; Anticoagulants; Betamethasone; Bradycardia; Caffeine; Cardiomyopathies; Cesarean Section

2011
Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients.
    Circulation research, 2013, Feb-15, Volume: 112, Issue:4

    Topics: Adult; Animals; Atropine; Bradycardia; Caffeine; Calcium Signaling; Calsequestrin; Cardiac Pacing, A

2013
Effects of caffeine and/or nasal CPAP treatment on laryngeal chemoreflexes in preterm lambs.
    Journal of applied physiology (Bethesda, Md. : 1985), 2013, Mar-01, Volume: 114, Issue:5

    Topics: Animals; Animals, Newborn; Apnea; Arterial Pressure; Bradycardia; Caffeine; Continuous Positive Airw

2013
Aminophylline versus caffeine citrate...
    Acta paediatrica (Oslo, Norway : 1992), 1995, Volume: 84, Issue:10

    Topics: Aminophylline; Apnea; Bradycardia; Caffeine; Cardiotonic Agents; Citrates; Clinical Trials as Topic;

1995
Apnea following spinal anaesthesia in two former pre-term infants.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:10

    Topics: Age Factors; Anesthesia, Spinal; Anesthetics, Local; Apnea; Benzoates; Bradycardia; Caffeine; Centra

1998
The effect of theophylline on apnoea and hypoxaemic episodes in the premature neonate during the 1st 3 days after birth.
    Annals of tropical paediatrics, 1998, Volume: 18, Issue:3

    Topics: Apnea; Blood Pressure; Bradycardia; Bronchodilator Agents; Caffeine; Female; Gestational Age; Humans

1998
The xanthine treatment of apnea of prematurity.
    Pediatrics, 1975, Volume: 55, Issue:5

    Topics: Aminophylline; Apnea; Bradycardia; Caffeine; Humans; Hypoxia; Infant, Newborn; Infant, Premature, Di

1975
Fetal and newborn lambs differ in their cardiopulmonary responsiveness to adenosine agonists.
    Developmental pharmacology and therapeutics, 1990, Volume: 15, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Animals, Newborn; Blood Pressure; Bradycardia

1990
[Effect of methylxanthines on periodic respiration and acid gastroesophageal reflux in newborn infants].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1990, Volume: 138, Issue:3

    Topics: Bradycardia; Caffeine; Citrates; Drug Combinations; Drug Therapy, Combination; Gastric Acidity Deter

1990
Transplacentally acquired caffeine and the occurrence of apnea, bradycardia, and periodic breathing in preterm infants: preliminary communication.
    Pediatric pulmonology, 1989, Volume: 7, Issue:2

    Topics: Apnea; Bradycardia; Caffeine; Cheyne-Stokes Respiration; Chromatography, High Pressure Liquid; Femal

1989
Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine.
    Southern medical journal, 1988, Volume: 81, Issue:9

    Topics: Bradycardia; Caffeine; Female; Humans; Infant, Newborn; Male; Neonatal Abstinence Syndrome; Respirat

1988
Infant apnea.
    Pediatric clinics of North America, 1986, Volume: 33, Issue:3

    Topics: Airway Obstruction; Apnea; Bradycardia; Caffeine; Cardiography, Impedance; Home Nursing; Humans; Inf

1986
[Effectiveness of low- and high-dose caffeine on idiopathic bradycardia and hypoxemia in premature infants].
    Helvetica paediatrica acta, 1985, Volume: 40, Issue:2-3

    Topics: Bradycardia; Caffeine; Citrates; Dose-Response Relationship, Drug; Drug Combinations; Humans; Hypoxi

1985
[Therapy of arrhythmias].
    Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete, 1973, Volume: 54, Issue:8-9

    Topics: Ajmaline; Arrhythmias, Cardiac; Atrial Fibrillation; Bradycardia; Caffeine; Cardiac Complexes, Prema

1973
[Antagonism of circulation effect of adenosine by theophylline].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:3

    Topics: Adenine Nucleotides; Aminophylline; Animals; Arteries; Blood Circulation; Blood Platelets; Blood Pre

1970