caffeine and Blood Pressure, High studies

Research Excerpts

Excerpt	Relevance	Reference
"This systematic review aimed to study caffeine's effect on the cardiometabolic markers of the metabolic syndrome and to evaluate caffeine's application as a potential therapeutic agent in rat models."	9.41	Systematic review of the effect of caffeine therapy effect on cardiometabolic markers in rat models of the metabolic syndrome. ( Al Ansari, AM; Alabbasi, AMA; Alhadi, IA; AlSaleh, AFF, 2023)
"The effects of caffeine on blood pressure (BP) and cortisol secretion were examined during elevated work stress in medical students at high versus low risk for hypertension."	9.09	Additive pressor effects of caffeine and stress in male medical students at risk for hypertension. ( al'Absi, M; Lovallo, WR; Passey, RB; Shepard, JD; Whitsett, TL, 2000)
"Examined the cardiovascular effects of caffeine plus behavioral stress in men low versus high in risk of essential hypertension."	9.07	Hypertension risk and caffeine's effect on cardiovascular activity during mental stress in young men. ( Everson, SA; Lovallo, WR; Passey, RB; Pincomb, GA; Sung, BH; Wilson, MF, 1991)
"To determine the effects on blood pressure of modifying dietary caffeine intake in patients with mild and borderline hypertension by monitoring ambulatory and clinic blood pressure."	9.07	Caffeine restriction: effect on mild hypertension. ( Fowler, G; Freestone, S; Lovell, HG; Lyons, D; MacDonald, TM; Petrie, JC; Sharpe, K; Webster, J, 1991)
"The effect of caffeine on blood cortisol levels and blood pressures was examined during rest and in response to a challenging psychomotor task in men with a low versus high risk of essential hypertension."	9.06	Caffeine may potentiate adrenocortical stress responses in hypertension-prone men. ( Lovallo, WR; Passey, RB; Pincomb, GA; Sausen, KP; Sung, BH; Wilson, MF, 1989)
"Although 75 mg of phenylpropanolamine did not cause clinically relevant hypertension in our subjects, 150 mg of phenylpropanolamine and 75 mg of phenylpropanolamine plus 400 mg caffeine did result in significant blood pressure increases into the hypertensive range."	9.06	A double dose of phenylpropanolamine causes transient hypertension. ( Chernow, B; Clymer, R; Lake, CR; Quirk, RM; Zaloga, G, 1988)
"Final metabolites of caffeine (namely 3-MU, 7-MU, 3-MX and 7-MX), but not caffeine, significantly reduce the odds for hypertension in this population."	7.96	Caffeine and caffeine metabolites in relation to hypertension in U.S. adults. ( Ngueta, G, 2020)
"We sought to assess longitudinal relations of caffeinated coffee, decaffeinated coffee, and total caffeine intakes with mean blood pressure and incident hypertension in postmenopausal women in the Women's Health Initiative Observational Study."	7.83	Coffee and caffeine consumption and the risk of hypertension in postmenopausal women. ( Bird, CE; Chang, TI; Hedlin, HK; Manson, JE; Qin, F; Rhee, JJ; Stefanick, ML; Winkelmayer, WC; Zaslavsky, O, 2016)
"Caffeine is consumed by more than 85% of adults and little is known about its role on erectile dysfunction (ED) in population-based studies."	7.80	Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004. ( Canfield, S; Daniel, CR; Lopez, DS; Sinha, A; Tsilidis, KK; Wang, R; Zhu, H, 2014)
"We tested the hypothesis that long-term caffeine intake prevents the development of insulin resistance and hypertension in two pathological animal models: the high-fat (HF) and the high-sucrose (HSu) diet rat."	7.78	Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats. ( Conde, SV; Gonzalez, C; Guarino, MP; Monteiro, EC; Mota Carmo, M; Nunes da Silva, T, 2012)
"Coffee and caffeine consumption influence spontaneous conversion of atrial fibrillation."	7.77	Influence of coffee and caffeine consumption on atrial fibrillation in hypertensive patients. ( Farinetti, A; Mattioli, AV; Mattioli, G; Miloro, C; Pedrazzi, P, 2011)
"Higher caffeine intake during pregnancy seems to be associated with elevated systolic blood pressure levels in first and third trimester, but not with diastolic blood pressure levels."	7.77	Maternal caffeine intake, blood pressure, and the risk of hypertensive complications during pregnancy. The Generation R Study. ( Bakker, R; Hofman, A; Jaddoe, VW; Raat, H; Steegers, EA, 2011)
"Ephedra containing products (ECPs), which most often contain additional sources of caffeine alkaloids, may be an under-recognized cause of hypertension."	7.73	Complicated hypertension related to the abuse of ephedrine and caffeine alkaloids. ( Berman, JA; Kaufman, KR; Setty, A; Skotzko, C; Steiner, MJ, 2006)
"Caffeine acutely increases blood pressure, but the association between habitual consumption of caffeinated beverages and incident hypertension is uncertain."	7.73	Habitual caffeine intake and the risk of hypertension in women. ( Curhan, GC; Stampfer, MJ; Willett, WC; Winkelmayer, WC, 2005)
"Our previous studies supported the hypothesis that prolonged administration of caffeine to animals with high-renin hypertension causes progressive deterioration of renal function."	7.70	Effects of long-term caffeine consumption on renal function in spontaneously hypertensive heart failure prone rats. ( Jackson, EK; Tofovic, SP, 1999)
"We compared the acute effects of caffeine on arterial blood pressure (BP) in 5 hypertension risk groups composed of a total of 182 men."	7.70	Hypertension risk status and effect of caffeine on blood pressure. ( Hartley, TR; Lovallo, WR; Pincomb, GA; Sung, BH; Whitsett, TL; Wilson, MF, 2000)
" This article describes the case of a patient affected by pheochromocytoma in whom multiple organ failure developed after contemporary administration of ergotamine, caffeine, and nimesulide."	7.69	Pheochromocytoma crisis caused by contemporary ergotamine, caffeine, and nimesulide administration. ( Bartoli, P; Bonechi, F; Brandinelli, A; Del Rosso, A; Fradella, G; Ieri, A; Maioli, M; Mannelli, M; Mazza, F; Russo, L; Sansoni, M; Zipoli, A, 1997)
"We studied the effects of caffeine ingestion during pregnancy."	7.67	Effects of caffeine ingestion during pregnancy. ( Furuhashi, N; Hiruta, M; Sato, S; Suzuki, M; Takahashi, T; Tanaka, M, 1985)
"The purpose of this study was to determine whether or not caffeine would exacerbate renovascular hypertension."	7.67	Chronic caffeine administration exacerbates renovascular, but not genetic, hypertension in rats. ( Biaggioni, I; Branch, RA; Deray, G; Hamilton, R; Jackson, EK; Jackson, K; Ohnishi, A, 1986)
"Physicians and pharmacists should be alerted to the potential adverse effects of phenylpropanolamine-containing products, which may include exaggerated hypertensive effects, arrhythmias (premature ventricular and atrial contractions together with paroxysmal ventricular or atrial tachycardia), psychotic reactions, and neurologic effects (grand mal seizures and intracerebral hemorrhage)."	7.66	Cardiac arrhythmias after phenylpropanolamine ingestion. ( Clark, JE; Simon, WA, 1983)
" After adjusting for coffee, there was a stepwise dose-response relationship between caffeine intake and hypertension risk; compared to the lowest intake (<50 mg/day), those in the highest intake (≥300 mg/day) had a 16% increase in risk; HR 1."	5.48	Coffee, tea, caffeine, and risk of hypertension: The Singapore Chinese Health Study. ( Chei, CL; Koh, WP; Loh, JK; Soh, A; Yuan, JM, 2018)
"This systematic review aimed to study caffeine's effect on the cardiometabolic markers of the metabolic syndrome and to evaluate caffeine's application as a potential therapeutic agent in rat models."	5.41	Systematic review of the effect of caffeine therapy effect on cardiometabolic markers in rat models of the metabolic syndrome. ( Al Ansari, AM; Alabbasi, AMA; Alhadi, IA; AlSaleh, AFF, 2023)
"Caffeine displays significant antioxidant ability in protecting membranes against oxidative damage and can lower the risk of insulin resistance."	5.40	Caffeine intake improves fructose-induced hypertension and insulin resistance by enhancing central insulin signaling. ( Chen, BR; Cheng, PW; Cheng, WH; Ho, WY; Liou, JC; Liu, CP; Lu, PJ; Sun, GC; Tseng, CJ; Yeh, TC, 2014)
"Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder frequently associated with renal failure, hypertension, and other abnormalities."	5.31	Chronic caffeine consumption exacerbates hypertension in rats with polycystic kidney disease. ( Tanner, GA; Tanner, JA, 2001)
"Caffeine can produce a mild hypertensive effect for a few hours after use."	5.27	Caffeine-containing beverages and the prevalence of hypertension. ( Birkett, NJ; Logan, AG, 1988)
"The effects of caffeine on blood pressure (BP) and cortisol secretion were examined during elevated work stress in medical students at high versus low risk for hypertension."	5.09	Additive pressor effects of caffeine and stress in male medical students at risk for hypertension. ( al'Absi, M; Lovallo, WR; Passey, RB; Shepard, JD; Whitsett, TL, 2000)
"Effects of caffeine on ambulatory blood pressure, heart rate, renin-angiotensin system, and ANP were studied in patients treated for mild to moderate hypertension in a randomized, double-blind, placebo-controlled, cross-over trial comparing 2 weeks of caffeine-free diet with 2 weeks of regular coffee use."	5.07	Effect of coffee on ambulatory blood pressure in patients with treated hypertension. ( Andreasson, A; Eggertsen, R; Hansson, L; Hedner, T; Karlberg, BE, 1993)
"To determine the effects on blood pressure of modifying dietary caffeine intake in patients with mild and borderline hypertension by monitoring ambulatory and clinic blood pressure."	5.07	Caffeine restriction: effect on mild hypertension. ( Fowler, G; Freestone, S; Lovell, HG; Lyons, D; MacDonald, TM; Petrie, JC; Sharpe, K; Webster, J, 1991)
"Examined the cardiovascular effects of caffeine plus behavioral stress in men low versus high in risk of essential hypertension."	5.07	Hypertension risk and caffeine's effect on cardiovascular activity during mental stress in young men. ( Everson, SA; Lovallo, WR; Passey, RB; Pincomb, GA; Sung, BH; Wilson, MF, 1991)
"Although 75 mg of phenylpropanolamine did not cause clinically relevant hypertension in our subjects, 150 mg of phenylpropanolamine and 75 mg of phenylpropanolamine plus 400 mg caffeine did result in significant blood pressure increases into the hypertensive range."	5.06	A double dose of phenylpropanolamine causes transient hypertension. ( Chernow, B; Clymer, R; Lake, CR; Quirk, RM; Zaloga, G, 1988)
"The effect of caffeine on blood cortisol levels and blood pressures was examined during rest and in response to a challenging psychomotor task in men with a low versus high risk of essential hypertension."	5.06	Caffeine may potentiate adrenocortical stress responses in hypertension-prone men. ( Lovallo, WR; Passey, RB; Pincomb, GA; Sausen, KP; Sung, BH; Wilson, MF, 1989)
"The effect of caffeine consumption on mortality was evaluated in a historical cohort study of 10,064 diagnosed hypertensive individuals participating in the Hypertension Detection and Follow-up Program from 1973 to 1979."	5.06	Mortality patterns among hypertensives by reported level of caffeine consumption. ( Annegers, JF; Curb, JD; Heyden, S; Howson, C; Lee, ES; Lee, M; Martin, JB, 1988)
"The MEDLINE and Current Contents databases were searched from 1966 to April 1999 using the text words 'coffee or caffeine' and 'blood pressure or hypertension'."	4.80	Coffee, caffeine and blood pressure: a critical review. ( Korpela, R; Niittynen, L; Nurminen, ML; Vapaatalo, H, 1999)
"In this study, the risks of albuminuria, hyperfiltration, and hypertension increased with heavy coffee intake only among those with the AC and CC genotypes of CYP1A2 at rs762551 associated with slow caffeine metabolism, suggesting that caffeine may play a role in the development of kidney disease in susceptible individuals."	4.31	CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction. ( El-Sohemy, A; Mahdavi, S; Palatini, P, 2023)
" In the most metabolically unhealthy group, with the oldest age, highest BMI, and more cases of hypertension, hyperglycemia, and CVD, there was a nonlinear relationship between caffeine intake and serum thyroid stimulating hormone (TSH) level."	4.31	Relationship between caffeine intake and thyroid function: results from NHANES 2007-2012. ( Cao, M; Huang, R; Wang, X; Xu, G; Zheng, J; Zhou, Y; Zhu, S; Zhu, X, 2023)
" However, the effects of coffee on arterial hypertension are still objects of active discussion mainly because of the debated effects of caffeine on blood pressure and cardiovascular system."	4.12	Coffee and blood pressure: exciting news! ( Borghi, C, 2022)
"Final metabolites of caffeine (namely 3-MU, 7-MU, 3-MX and 7-MX), but not caffeine, significantly reduce the odds for hypertension in this population."	3.96	Caffeine and caffeine metabolites in relation to hypertension in U.S. adults. ( Ngueta, G, 2020)
"We sought to assess longitudinal relations of caffeinated coffee, decaffeinated coffee, and total caffeine intakes with mean blood pressure and incident hypertension in postmenopausal women in the Women's Health Initiative Observational Study."	3.83	Coffee and caffeine consumption and the risk of hypertension in postmenopausal women. ( Bird, CE; Chang, TI; Hedlin, HK; Manson, JE; Qin, F; Rhee, JJ; Stefanick, ML; Winkelmayer, WC; Zaslavsky, O, 2016)
"Caffeine is consumed by more than 85% of adults and little is known about its role on erectile dysfunction (ED) in population-based studies."	3.80	Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004. ( Canfield, S; Daniel, CR; Lopez, DS; Sinha, A; Tsilidis, KK; Wang, R; Zhu, H, 2014)
" The day before the occurrence of these acute lesions, he self medicated with a drug containing ergotamine and caffeine because of a headache."	3.79	[Digital necrosis in hand by uncommon mechanism]. ( Lashak, C; Leroux, MB; Mazzurco, M, 2013)
"We tested the hypothesis that long-term caffeine intake prevents the development of insulin resistance and hypertension in two pathological animal models: the high-fat (HF) and the high-sucrose (HSu) diet rat."	3.78	Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats. ( Conde, SV; Gonzalez, C; Guarino, MP; Monteiro, EC; Mota Carmo, M; Nunes da Silva, T, 2012)
"Coffee and caffeine consumption influence spontaneous conversion of atrial fibrillation."	3.77	Influence of coffee and caffeine consumption on atrial fibrillation in hypertensive patients. ( Farinetti, A; Mattioli, AV; Mattioli, G; Miloro, C; Pedrazzi, P, 2011)
"Higher caffeine intake during pregnancy seems to be associated with elevated systolic blood pressure levels in first and third trimester, but not with diastolic blood pressure levels."	3.77	Maternal caffeine intake, blood pressure, and the risk of hypertensive complications during pregnancy. The Generation R Study. ( Bakker, R; Hofman, A; Jaddoe, VW; Raat, H; Steegers, EA, 2011)
" Correlates associated with both cortical and trabecular vBMD were age (-), caffeine intake (-), total calcium intake (+), nontrauma fracture (-), and hypertension (+)."	3.76	Correlates of trabecular and cortical volumetric bone mineral density of the radius and tibia in older men: the Osteoporotic Fractures in Men Study. ( Barbour, KE; Boudreau, R; Cauley, JA; Ensrud, KE; Evans, RW; Gordon, CL; Horwitz, MJ; Petit, MA; Strotmeyer, ES; Zmuda, JM, 2010)
" Currently published data has been stressed that the metyloxantine consumption increases the risk of coronary heart disease, arterial hypertension, arterial stiffness, and an elevation of cholesterol and homocysteine plasma concentration."	3.75	[Side effects of caffeine]. ( Burdan, F; Dworzański, W; Opielak, G, 2009)
"Ephedra containing products (ECPs), which most often contain additional sources of caffeine alkaloids, may be an under-recognized cause of hypertension."	3.73	Complicated hypertension related to the abuse of ephedrine and caffeine alkaloids. ( Berman, JA; Kaufman, KR; Setty, A; Skotzko, C; Steiner, MJ, 2006)
"Caffeine acutely increases blood pressure, but the association between habitual consumption of caffeinated beverages and incident hypertension is uncertain."	3.73	Habitual caffeine intake and the risk of hypertension in women. ( Curhan, GC; Stampfer, MJ; Willett, WC; Winkelmayer, WC, 2005)
"In Western society, the triad of hypertension, metabolic syndrome and obesity (which caries a high risk for renal disease) is increasing, as is the intake of caffeine."	3.71	Renal and metabolic effects of caffeine in obese (fa/fa(cp)), diabetic, hypertensive ZSF1 rats. ( Bastacky, SI; Jackson, EK; Kusaka, H; Tofovic, SP, 2001)
"To clarify whether the Ca2+ uptake function of the sarcoplasmic reticulum (SR) during arterial contraction is altered in hypertension, the effects of cyclopiazonic acid (CPA) and thapsigargin, which inhibit SR Ca2+-ATPase, on the contractile responses to Bay k 8644, an agonist of L-type Ca2+ channels, were compared in endothelium-denuded strips of carotid arteries from 13-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY)."	3.71	Ca2+ buffering function of the sarcoplasmic reticulum is increased in the carotid artery from spontaneously hypertensive rats. ( Asano, M; Nomura, Y, 2002)
"Our study confirmed, in a population-based setting, the importance of the known determinants of fasting tHcy and suggested that other dietary and lifestyle factors, including vitamin B-6, riboflavin, alcohol, and caffeine intakes as well as smoking and hypertension, influence circulating tHcy concentrations."	3.71	Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. ( Bostom, AG; Jacques, PF; Rich, S; Rosenberg, IH; Selhub, J; Wilson, PW, 2001)
"We compared the acute effects of caffeine on arterial blood pressure (BP) in 5 hypertension risk groups composed of a total of 182 men."	3.70	Hypertension risk status and effect of caffeine on blood pressure. ( Hartley, TR; Lovallo, WR; Pincomb, GA; Sung, BH; Whitsett, TL; Wilson, MF, 2000)
"Our previous studies supported the hypothesis that prolonged administration of caffeine to animals with high-renin hypertension causes progressive deterioration of renal function."	3.70	Effects of long-term caffeine consumption on renal function in spontaneously hypertensive heart failure prone rats. ( Jackson, EK; Tofovic, SP, 1999)
" The pharmaceutical cost of weight loss, cardiac risk reduction, and low-density lipoprotein (LDL) cholesterol reduction was calculated for fenfluramine with mazindol or phentermine, caffeine with ephedrine, or mazindol alone, and compared to approved lipid-lowering medications."	3.70	Pharmaceutical cost savings of treating obesity with weight loss medications. ( Bray, GA; Greenway, FL; Rood, JC; Ryan, DH; Smith, SR; Tucker, EW, 1999)
" This article describes the case of a patient affected by pheochromocytoma in whom multiple organ failure developed after contemporary administration of ergotamine, caffeine, and nimesulide."	3.69	Pheochromocytoma crisis caused by contemporary ergotamine, caffeine, and nimesulide administration. ( Bartoli, P; Bonechi, F; Brandinelli, A; Del Rosso, A; Fradella, G; Ieri, A; Maioli, M; Mannelli, M; Mazza, F; Russo, L; Sansoni, M; Zipoli, A, 1997)
"Since the membrane Ca2+ handling properties of the arterial smooth muscle sarcoplasmic reticulum may be altered in genetic hypertension, we studied caffeine- and noradrenaline-induced contractions in tail arteries from spontaneously hypertensive rats (SHR) at the prehypertensive stage (4 weeks old) and from age-matched Wistar-Kyoto rats (WKY)."	3.68	Alteration in sarcoplasmic reticulum-dependent contraction of tail arteries in response to caffeine and noradrenaline in spontaneously hypertensive rats. ( Aoki, K; Dohi, Y; Fujimoto, S; Kojima, M; Matsuda, T, 1990)
"The effects of caffeine on aortic smooth muscle contractility during hypertension were studied in SHR and WKY control rats."	3.68	In vitro caffeine induced aortic smooth muscle reactivity in rat. ( Bennett, T; Mangroo, T; Neves, M; Rahmani, MA, 1990)
"We measured and compared the anaesthetic requirements, incidences of chest wall rigidity and intraoperative hypertension, and time for recovery from anaesthesia after high dose fentanyl-oxygen anaesthesia in patients with and without histories of smoking, alcoholic intake and caffeine consumption who were undergoing coronary artery bypass grafting operations."	3.67	The effect of population habits on side effects and narcotic requirements during high-dose fentanyl anaesthesia. ( de Lange, S; Stanley, TH, 1984)
"We studied the effects of caffeine ingestion during pregnancy."	3.67	Effects of caffeine ingestion during pregnancy. ( Furuhashi, N; Hiruta, M; Sato, S; Suzuki, M; Takahashi, T; Tanaka, M, 1985)
"The purpose of this study was to determine whether or not caffeine would exacerbate renovascular hypertension."	3.67	Chronic caffeine administration exacerbates renovascular, but not genetic, hypertension in rats. ( Biaggioni, I; Branch, RA; Deray, G; Hamilton, R; Jackson, EK; Jackson, K; Ohnishi, A, 1986)
"Physicians and pharmacists should be alerted to the potential adverse effects of phenylpropanolamine-containing products, which may include exaggerated hypertensive effects, arrhythmias (premature ventricular and atrial contractions together with paroxysmal ventricular or atrial tachycardia), psychotic reactions, and neurologic effects (grand mal seizures and intracerebral hemorrhage)."	3.66	Cardiac arrhythmias after phenylpropanolamine ingestion. ( Clark, JE; Simon, WA, 1983)
" The non-linear dose-response analysis detected the dosage of supplementation >400 mg/day is effective for increasing DBP (p = 0."	3.01	The effects of caffeine supplementation on blood pressure in adults: A systematic review and dose-response meta-analysis. ( Abbas-Hashemi, SA; Asbaghi, O; Hosseininasab, D; Rastgoo, S; Shiraseb, F, 2023)
"Caffeine has been shown to have effects on certain areas of cognition, but in executive functioning the research is limited and also inconsistent."	2.82	Investigating the effects of caffeine on executive functions using traditional Stroop and a new ecologically-valid virtual reality task, the Jansari assessment of Executive Functions (JEF(©)). ( Chapman, E; Jansari, AS; Lavan, N; Soar, K; Turner, JJ, 2016)
"Caffeine may therefore cause persistent BP effects in persons who are regular consumers, even when daily intake is at moderately high levels."	2.71	Blood pressure response to caffeine shows incomplete tolerance after short-term regular consumption. ( Lovallo, WR; McKey, BS; Sung, BH; Vincent, AS; Whitsett, TL; Wilson, MF, 2004)
"2 Caffeine (300 mg) was given orally before any treatment and at the beginning of the last day of each treatment course."	2.65	Decreased systemic clearance of caffeine due to cimetidine. ( Broughton, LJ; Rogers, HJ, 1981)
"Ventricular ectopic beats are commonly seen in daily clinical practice."	2.48	RETRACTED: Ventricular Ectopic Beats: An Overview of Management Considerations ( Chockalingam, A; Ingole, A; Jadhav, A, 2012)
" Each of these three modalities--weight control, alcohol restriction, and sodium restriction--was found to be capable not only of independently controlling blood pressure (particularly in patients with mild hypertension) but also of reducing the number and dosage of prescribed pharmacological agents, should their prescription be indicated."	2.37	Nonpharmacological approaches to the control of high blood pressure. Final report of the Subcommittee on Nonpharmacological Therapy of the 1984 Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. ( , 1986)
"Essential hypertension is more prevalent and vascular disease more severe in blacks than in whites."	2.37	Risks for arterial hypertension. ( Messerli, FH; Ruddel, H; Schmieder, RE, 1986)
"Caffeine has beneficial effects on firefighter job performance reducing fatigue and improving psychomotor vigilance."	1.72	Cardiometabolic Biomarkers and Habitual Caffeine Consumption Associate with the Adverse Ambulatory Blood Pressure Response to Strenuous Physical Exertion among Firefighters. ( Berkowsky, RS; Chen, MH; Fernandez, AB; Gans, KM; Parducci, PM; Pescatello, LS; Taylor, BA; Wu, Y; Zaleski, AL; Zhang, Y, 2022)
"Caffeine is a widely used dietary stimulant, and cases of caffeine overdoses, sometimes leading to death, are increasing."	1.62	Suicidal attempt with caffeine overdose treated with dexmedetomidine: a case report. ( Kitano, T; Noda, T; Okajima, M; Sato, K; Taniguchi, T, 2021)
"Caffeine-treated male mice had substantially higher fecal corticosterone and urinary 8-hydroxydeoxyguanosine at 14 weeks, suggestive of chronic stress."	1.62	Effects of Neonatal Caffeine Administration on Vessel Reactivity in Adult Mice. ( Berkelhamer, S; Chandrasekharan, P; Gugino, S; Kumar, VHS; Nielsen, L; Singh, AP; Wang, H, 2021)
" After adjusting for coffee, there was a stepwise dose-response relationship between caffeine intake and hypertension risk; compared to the lowest intake (<50 mg/day), those in the highest intake (≥300 mg/day) had a 16% increase in risk; HR 1."	1.48	Coffee, tea, caffeine, and risk of hypertension: The Singapore Chinese Health Study. ( Chei, CL; Koh, WP; Loh, JK; Soh, A; Yuan, JM, 2018)
"Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear."	1.46	Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. ( Blanco, P; Bolen, CR; Chang, J; Daburon, S; Davis, MM; Déchanet-Merville, J; Dekker, CL; Douchet, I; Faustin, B; Fragiadakis, GK; Furman, D; Ganio, EA; Gaudilliere, B; Haddad, F; Jojic, V; Kuo, CJ; Lartigue, L; Moreau, JF; Nolan, GP; Spitzer, MH, 2017)
"Hypertension is often associated with skeletal muscle pathological conditions related to function and metabolism."	1.40	Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats: cytofluorimetric and gene expression analysis. ( Camerino, GM; Cannone, M; Conte Camerino, D; Conte, E; De Bellis, M; Fraysse, B; Liantonio, A; Pierno, S; Scaramuzzi, A; Tricarico, D, 2014)
"Caffeine displays significant antioxidant ability in protecting membranes against oxidative damage and can lower the risk of insulin resistance."	1.40	Caffeine intake improves fructose-induced hypertension and insulin resistance by enhancing central insulin signaling. ( Chen, BR; Cheng, PW; Cheng, WH; Ho, WY; Liou, JC; Liu, CP; Lu, PJ; Sun, GC; Tseng, CJ; Yeh, TC, 2014)
"The caffeine percentage was tested on one cup (250 mL) of each type of coffee (Arabian, Turkish, American and an instant coffee preparation) using two methods."	1.37	The effect of four coffee types on normotensive rats and normal/hypertensive human volunteers. ( Al-Jaber, NA; Al-Nafisah, RS; Al-Outhman, MR; Al-Samkhan, R; Al-Shamery, J; Al-Shdoukhi, IF; Awaad, AS; Baqer, M; Soliman, GA, 2011)
"Metabolic syndrome was defined as the presence of > or = 3 of the following: waist circumference > or = 35 inches (women) or > or = 40 inches (men); fasting blood glucose > or = 100 mg/dL; serum triglycerides > or = 150 mg/dL; blood pressure > or = 135/85 mm Hg; and high-density lipoprotein cholesterol < 40 mg/dL (men) or < 50 mg/dL (women)."	1.34	Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. ( D'Agostino, RB; Dhingra, R; Fox, CS; Gaziano, JM; Jacques, PF; Meigs, JB; Sullivan, L; Vasan, RS; Wang, TJ, 2007)
"Adenosine is an endogenous nucleoside with potent vasodilatory capacities, released under ischaemic conditions in particular."	1.33	Mechanisms of adenosine-induced renal vasodilatation in hypertensive patients. ( de Leeuw, PW; Houben, AJ; Koster, D; Kroon, AA; Postma, CT; Smits, P; van Engelshoven, JM; Wierema, TK, 2005)
"Caffeine was used as a tool to investigate whether the sarcoplasmic reticulum (SR) properties in single."	1.31	Caffeine thresholds for contraction in electrophoretically typed, mechanically skinned muscle fibres from SHR and WKY rats. ( Bortolotto, SK; Stephenson, DG; Stephenson, GM, 2001)
"Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder frequently associated with renal failure, hypertension, and other abnormalities."	1.31	Chronic caffeine consumption exacerbates hypertension in rats with polycystic kidney disease. ( Tanner, GA; Tanner, JA, 2001)
"Information on the history of nephrolithiasis, physician-diagnosed hypertension, and other relevant exposures was obtained by biennial mailed questionnaire."	1.30	Nephrolithiasis and risk of hypertension in women. ( Curhan, GC; Madore, F; Speizer, FE; Stampfer, MJ; Willett, WC, 1998)
"Ryanodine did not cause contraction during Ca2+ loading, but caffeine-induced contractions were reduced after ryanodine treatment in both groups."	1.29	Recycling and buffering of intracellular calcium in vascular smooth muscle from genetically hypertensive rats. ( Ansari, MN; Ghosh, S; Kanagy, NL; Webb, RC, 1994)
"Treatment with ramipril reduced blood pressure and force development in response to Bay K8644 in adult SHRSP, although not to levels of WKY rats, whereas WKY rats were unaffected by treatment."	1.29	Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats. ( Traub, O; Webb, RC, 1993)
"In ryanodine-treated arteries, the rate and magnitude of high-potassium-induced contraction were enhanced slightly in SHR and greatly in WKY rats, resulting in no final difference between SHR and WKY rats."	1.28	Malfunction of arterial sarcoplasmic reticulum leading to faster and greater contraction induced by high-potassium depolarization in young spontaneously hypertensive rats. ( Aoki, K; Asano, M; Fujimoto, S; Kojima, M; Matsuda, T, 1991)
" Twenty-two percent of diet aid users and 7 percent of cold medicine users reported that they deliberately used more than the dosage recommended to improve efficacy."	1.28	Phenylpropanolamine and caffeine use among diet center clients. ( Lake, CR; Quirk, R; Rosenberg, D, 1990)
"Caffeine can produce a mild hypertensive effect for a few hours after use."	1.27	Caffeine-containing beverages and the prevalence of hypertension. ( Birkett, NJ; Logan, AG, 1988)
"Secondly, hypertension is a risk factor for premature cardiovascular morbidity and mortality."	1.27	Nutritional and lifestyle approaches to the prevention and management of hypertension. ( Egan, B, 1985)

Timeframe	Studies, this research(%)	All Research%
pre-1990	71 (28.51)	18.7374
1990's	57 (22.89)	18.2507
2000's	53 (21.29)	29.6817
2010's	53 (21.29)	24.3611
2020's	15 (6.02)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparison of Synthetic and Natural Caffeine on Hemodynamic Parameters in Young, Healthy Volunteers: A Randomized, Double Blind, Crossover Study[NCT03495063]		0 participants (Actual)	Interventional	2019-09-16	Withdrawn (stopped due to Unable to quantify caffeine)
The Effect of Energy Drink on Cardiovascular Variables: A Randomized Controlled Trial[NCT03841838]		20 participants (Actual)	Interventional	2019-02-23	Completed
Evaluation of Energy Drink Consumption on Electrocardiographic, Vascular and Hematologic Parameters in Young Healthy Volunteers: A Randomized, Double Blind, Active-Controlled, Crossover Study[NCT03021616]		2 participants (Actual)	Interventional	2017-06-26	Terminated (stopped due to Results from sister study at University of the Pacific were conclusive.)
Residual Immune Activation in HIV-infected Patients on Successful cART: Association Between Inflammasome Activation in Monocytes by Circulating Metabolites and Non AIDS Defining Comorbidities[NCT03191175]		55 participants (Actual)	Observational	2017-07-03	Completed
Immune Senescence in the Elderly: Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages[NCT01827462]	Phase 4	136 participants (Actual)	Interventional	2007-10-31	Completed
Evaluation of the Effect of Espresso on Platelet Aggregability in Patients With Coronary Artery Disease[NCT04827251]		30 participants (Anticipated)	Interventional	2019-03-18	Recruiting
Effect of Low Intensity Strength Training Combined With Moderate Blood Flow Restriction on Muscle Vasodilatation and Arterial Stiffness in Elders With Low Gait Velocity.[NCT03272737]		26 participants (Actual)	Interventional	2018-02-04	Completed
Effect of Intermittent Hypoxia on Ischemia-reperfusion Injury in Healthy Individuals[NCT05423470]		41 participants (Actual)	Interventional	2019-05-30	Completed
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534]		29 participants (Actual)	Observational	2015-09-30	Completed
[NCT00005243]		0 participants	Observational	1989-04-30	Completed
Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry[NCT05158751]		100 participants (Anticipated)	Observational	2023-01-31	Not yet recruiting
Role of a Novel Implantable Loop Recorder in the Management of Premature Ventricular Contractions[NCT06060548]		50 participants (Anticipated)	Observational	2022-04-20	Recruiting
Risk Stratifications for Patients Come With Palpitations in Assiut and Suez Canal University Hospitals[NCT06103305]		208 participants (Anticipated)	Observational	2023-10-31	Not yet recruiting
[NCT00005185]		0 participants	Observational	1986-04-30	Completed
[NCT00005314]		694 participants (Actual)	Observational	1986-07-31	Completed
[NCT00000485]	Phase 3	0 participants	Interventional	1971-05-31	Completed
[NCT00005144]		0 participants	Observational	1978-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	Participants (Count of Participants)
18-30 Years Old at Enrollment	59
60-79 Years Old at Enrollment	37
80-100 Years Old at Enrollment	40

Article	Year
Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies. Journal of Korean medical science, 2022, 11-21, Volume: 37, Issue:45 Topics: Caffeine; Coffee; Cohort Studies; Humans; Hypertension; Longitudinal Studies	2022
Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies. Journal of Korean medical science, 2022, 11-21, Volume: 37, Issue:45 Topics: Caffeine; Coffee; Cohort Studies; Humans; Hypertension; Longitudinal Studies	2022
Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies. Journal of Korean medical science, 2022, 11-21, Volume: 37, Issue:45 Topics: Caffeine; Coffee; Cohort Studies; Humans; Hypertension; Longitudinal Studies	2022
Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies. Journal of Korean medical science, 2022, 11-21, Volume: 37, Issue:45 Topics: Caffeine; Coffee; Cohort Studies; Humans; Hypertension; Longitudinal Studies	2022
Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies. Journal of Korean medical science, 2022, 11-21, Volume: 37, Issue:45 Topics: Caffeine; Coffee; Cohort Studies; Humans; Hypertension; Longitudinal Studies	2022
Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies. Journal of Korean medical science, 2022, 11-21, Volume: 37, Issue:45 Topics: Caffeine; Coffee; Cohort Studies; Humans; Hypertension; Longitudinal Studies	2022
Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies. Journal of Korean medical science, 2022, 11-21, Volume: 37, Issue:45 Topics: Caffeine; Coffee; Cohort Studies; Humans; Hypertension; Longitudinal Studies	2022
Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies. Journal of Korean medical science, 2022, 11-21, Volume: 37, Issue:45 Topics: Caffeine; Coffee; Cohort Studies; Humans; Hypertension; Longitudinal Studies	2022
Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies. Journal of Korean medical science, 2022, 11-21, Volume: 37, Issue:45 Topics: Caffeine; Coffee; Cohort Studies; Humans; Hypertension; Longitudinal Studies	2022
Systematic review of the effect of caffeine therapy effect on cardiometabolic markers in rat models of the metabolic syndrome. BMC endocrine disorders, 2023, Feb-06, Volume: 23, Issue:1 Topics: Animals; Caffeine; Hypertension; Insulin Resistance; Metabolic Syndrome; Obesity; Rats	2023
The impact of genetic variability on the relationship between caffeine and cardiometabolic outcomes: A systematic review. Nutrition bulletin, 2023, Volume: 48, Issue:1 Topics: Adult; Caffeine; Cardiovascular Diseases; Cross-Sectional Studies; Cytochrome P-450 CYP1A2; Diabetes	2023
The effects of caffeine supplementation on blood pressure in adults: A systematic review and dose-response meta-analysis. Clinical nutrition ESPEN, 2023, Volume: 58 Topics: Adolescent; Adult; Blood Pressure; Caffeine; Dietary Supplements; Female; Humans; Hypertension; Male	2023
Coffee and Arterial Hypertension. Current hypertension reports, 2021, 08-09, Volume: 23, Issue:7 Topics: Adult; Blood Pressure; Caffeine; Coffee; Humans; Hypertension	2021
Coffee Consumption and Cardiovascular Disease: A Condensed Review of Epidemiological Evidence and Mechanisms. Journal of agricultural and food chemistry, 2018, May-30, Volume: 66, Issue:21 Topics: Aged; Blood Pressure; Caffeine; Cardiovascular Diseases; Coffee; Female; Humans; Hypertension; Male;	2018
Are coffee's alleged health protective effects real or artifact? The enduring disjunction between relevant experimental and observational evidence. Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:8 Topics: Artifacts; Caffeine; Cardiovascular Diseases; Coffee; Diabetes Mellitus, Type 2; Humans; Hypertensio	2018
Caffeine and blood pressure: a critical review perspective. Nutrition research reviews, 2019, Volume: 32, Issue:2 Topics: Adolescent; Adult; Aged; Blood Pressure; Cacao; Caffeine; Coffee; Cohort Studies; Cytochrome P-450 C	2019
Blood pressure in relation to coffee and caffeine consumption. Current hypertension reports, 2014, Volume: 16, Issue:9 Topics: Blood Pressure; Caffeine; Central Nervous System Stimulants; Coffee; Global Health; Humans; Hyperten	2014
Impact of Acute Energy Drink Consumption on Blood Pressure Parameters: A Meta-analysis. The Annals of pharmacotherapy, 2016, Volume: 50, Issue:10 Topics: Blood Pressure; Caffeine; Databases, Factual; Energy Drinks; Heart Rate; Hemodynamics; Humans; Hyper	2016
Impact of Acute Energy Drink Consumption on Blood Pressure Parameters: A Meta-analysis. The Annals of pharmacotherapy, 2016, Volume: 50, Issue:10 Topics: Blood Pressure; Caffeine; Databases, Factual; Energy Drinks; Heart Rate; Hemodynamics; Humans; Hyper	2016
Impact of Acute Energy Drink Consumption on Blood Pressure Parameters: A Meta-analysis. The Annals of pharmacotherapy, 2016, Volume: 50, Issue:10 Topics: Blood Pressure; Caffeine; Databases, Factual; Energy Drinks; Heart Rate; Hemodynamics; Humans; Hyper	2016
Impact of Acute Energy Drink Consumption on Blood Pressure Parameters: A Meta-analysis. The Annals of pharmacotherapy, 2016, Volume: 50, Issue:10 Topics: Blood Pressure; Caffeine; Databases, Factual; Energy Drinks; Heart Rate; Hemodynamics; Humans; Hyper	2016
Sources of inaccuracy in the measurement of adult patients' resting blood pressure in clinical settings: a systematic review. Journal of hypertension, 2017, Volume: 35, Issue:3 Topics: Alcohol Drinking; Arm; Blood Pressure; Blood Pressure Determination; Caffeine; Cold Temperature; Eat	2017
RETRACTED: Ventricular Ectopic Beats: An Overview of Management Considerations The American journal of the medical sciences, 2012, Volume: 343, Issue:2 Topics: Caffeine; Catheter Ablation; Exercise; Heart Ventricles; Humans; Hypertension; Prevalence; Tachycard	2012
The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis. The American journal of clinical nutrition, 2011, Volume: 94, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Caffeine; Cardiovascular Diseases; Coffee; Feeding B	2011
Beyond salt: lifestyle modifications and blood pressure. European heart journal, 2011, Volume: 32, Issue:24 Topics: Alcohol Drinking; Biofeedback, Psychology; Blood Pressure; Caffeine; Central Nervous System Stimulan	2011
Drug-induced hypertension: an unappreciated cause of secondary hypertension. The American journal of medicine, 2012, Volume: 125, Issue:1 Topics: Adrenal Cortex Hormones; Alcohol Drinking; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal;	2012
Nutrition therapy for hypertension. Current diabetes reports, 2003, Volume: 3, Issue:5 Topics: Alcohol Drinking; Behavior Therapy; Caffeine; Diet; Exercise; Humans; Hypertension; Life Style; Meta	2003
[The effect of caffeine on hypertension]. Ugeskrift for laeger, 2005, Mar-14, Volume: 167, Issue:11 Topics: Adult; Aged; Blood Pressure; Caffeine; Central Nervous System Stimulants; Coffee; Female; Humans; Hy	2005
Cardiovascular effects of coffee: is it a risk factor? Progress in cardiovascular nursing, 2005,Spring, Volume: 20, Issue:2 Topics: Blood Glucose; Caffeine; Cardiovascular System; Coffee; Cooking; Diabetes Mellitus, Type 1; Drinking	2005
Cardiovascular sequelae of tobacco smoking. Critical care nursing clinics of North America, 2006, Volume: 18, Issue:1 Topics: Aortic Aneurysm, Abdominal; Arrhythmias, Cardiac; Atherosclerosis; Caffeine; Cardiovascular Diseases	2006
Treating patients with ventricular ectopic beats. Heart (British Cardiac Society), 2006, Volume: 92, Issue:11 Topics: Caffeine; Cardiomegaly; Electrocardiography; Exercise; Humans; Hypertension; Prognosis; Tachycardia,	2006
Treating patients with ventricular ectopic beats. Heart (British Cardiac Society), 2006, Volume: 92, Issue:11 Topics: Caffeine; Cardiomegaly; Electrocardiography; Exercise; Humans; Hypertension; Prognosis; Tachycardia,	2006
Treating patients with ventricular ectopic beats. Heart (British Cardiac Society), 2006, Volume: 92, Issue:11 Topics: Caffeine; Cardiomegaly; Electrocardiography; Exercise; Humans; Hypertension; Prognosis; Tachycardia,	2006
Treating patients with ventricular ectopic beats. Heart (British Cardiac Society), 2006, Volume: 92, Issue:11 Topics: Caffeine; Cardiomegaly; Electrocardiography; Exercise; Humans; Hypertension; Prognosis; Tachycardia,	2006
Treating patients with ventricular ectopic beats. Heart (British Cardiac Society), 2006, Volume: 92, Issue:11 Topics: Caffeine; Cardiomegaly; Electrocardiography; Exercise; Humans; Hypertension; Prognosis; Tachycardia,	2006
Treating patients with ventricular ectopic beats. Heart (British Cardiac Society), 2006, Volume: 92, Issue:11 Topics: Caffeine; Cardiomegaly; Electrocardiography; Exercise; Humans; Hypertension; Prognosis; Tachycardia,	2006
Treating patients with ventricular ectopic beats. Heart (British Cardiac Society), 2006, Volume: 92, Issue:11 Topics: Caffeine; Cardiomegaly; Electrocardiography; Exercise; Humans; Hypertension; Prognosis; Tachycardia,	2006
Treating patients with ventricular ectopic beats. Heart (British Cardiac Society), 2006, Volume: 92, Issue:11 Topics: Caffeine; Cardiomegaly; Electrocardiography; Exercise; Humans; Hypertension; Prognosis; Tachycardia,	2006
Treating patients with ventricular ectopic beats. Heart (British Cardiac Society), 2006, Volume: 92, Issue:11 Topics: Caffeine; Cardiomegaly; Electrocardiography; Exercise; Humans; Hypertension; Prognosis; Tachycardia,	2006
Timing of blood pressure measurement related to caffeine consumption. The Annals of pharmacotherapy, 2008, Volume: 42, Issue:1 Topics: Blood Pressure; Caffeine; Central Nervous System Stimulants; Humans; Hypertension; Neurotransmitter	2008
[Paradoxical blood pressure increases during increased sympathetic activity with the administration of non-beta 1-specific beta blockers]. Nederlands tijdschrift voor geneeskunde, 1994, Nov-19, Volume: 138, Issue:47 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Autonomic Nervous System Diseases; Blood	1994
Coffee, caffeine and blood pressure: a critical review. European journal of clinical nutrition, 1999, Volume: 53, Issue:11 Topics: Adolescent; Adult; Aged; Blood Pressure; Caffeine; Coffee; Hemodynamics; Humans; Hypertension; MEDLI	1999
[Dietary components, coffee or caffeine and essential hypertension]. Nihon rinsho. Japanese journal of clinical medicine, 1992, Volume: 50 Suppl Topics: Caffeine; Calcium, Dietary; Coffee; Diet; Dietary Fiber; Female; Fish Oils; Humans; Hypertension; Ma	1992
Long-term effectiveness of nonpharmacological treatment of hypertension. Hypertension (Dallas, Tex. : 1979), 1991, Volume: 18, Issue:3 Suppl Topics: Alcohol Drinking; Blood Pressure; Caffeine; Calcium; Diet; Diet, Sodium-Restricted; Exercise; Humans	1991
Nonpharmacological approaches to the control of high blood pressure. Final report of the Subcommittee on Nonpharmacological Therapy of the 1984 Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension (Dallas, Tex. : 1979), 1986, Volume: 8, Issue:5 Topics: Alcohol Drinking; Animals; Biofeedback, Psychology; Blood Pressure; Body Weight; Caffeine; Calcium,	1986
[Risks in the development of hypertension]. Medicina, 1988, Volume: 48, Issue:3 Topics: Alcohol Drinking; Blood Pressure; Caffeine; Contraceptives, Oral; Diet; Female; Humans; Hypertension	1988
Psychophysiologic factors in hypertension. Circulation, 1987, Volume: 76, Issue:1 Pt 2 Topics: Animals; Behavior; Behavior, Animal; Blood Pressure; Caffeine; Humans; Hypertension; Nicotine; Rats;	1987
Risks for arterial hypertension. Cardiology clinics, 1986, Volume: 4, Issue:1 Topics: Adult; Age Factors; Alcohol Drinking; Black People; Blood Pressure; Caffeine; Contraceptives, Oral;	1986
Management of essential hypertension. Whom, when and how to treat. Contributions to nephrology, 1987, Volume: 54 Topics: Alcohol Drinking; Antihypertensive Agents; Behavior Therapy; Caffeine; Calcium, Dietary; Clinical Tr	1987
Dietary factors and hypertension. Acta medica Scandinavica. Supplementum, 1985, Volume: 701 Topics: Caffeine; Calcium; Coffee; Diet; Dietary Fats; Ethanol; Humans; Hypertension; Obesity; Potassium; So	1985
Drug treatment in bronchial asthma. Seminars in drug treatment, 1973,Spring, Volume: 2, Issue:4 Topics: Acetylcysteine; Anti-Bacterial Agents; Asthma; Bronchodilator Agents; Caffeine; Drug Combinations; E	1973
[Epidemiology of hypertension]. Schweizerische medizinische Wochenschrift, 1973, Nov-24, Volume: 103, Issue:47 Topics: Adult; Age Factors; Alcohol Drinking; Blood Pressure; Caffeine; Cerebrovascular Disorders; Coronary	1973
[Coffee-drinking from the medical point of view]. Schweizerische medizinische Wochenschrift, 1973, Volume: 103, Issue:43 Topics: Adult; Blood Pressure; Caffeine; Coffee; Diabetes Mellitus; Feeding Behavior; Female; Gout; Health S	1973

Article	Year
Short-term effects of espresso coffee on heart rate variability and blood pressure in habitual and non-habitual coffee consumers--a randomized crossover study. Nutritional neuroscience, 2016, Volume: 19, Issue:4 Topics: Adult; Autonomic Nervous System; Biomarkers; Blood Pressure; Caffeine; Coffee; Cooking; Cross-Over S	2016
Investigating the effects of caffeine on executive functions using traditional Stroop and a new ecologically-valid virtual reality task, the Jansari assessment of Executive Functions (JEF(©)). Appetite, 2016, 10-01, Volume: 105 Topics: Adult; Caffeine; Central Nervous System Stimulants; Coffee; Double-Blind Method; Executive Function;	2016
Caffeine ingestion and intense resistance training minimize postexercise hypotension in normotensive and prehypertensive men. Research in sports medicine (Print), 2013, Volume: 21, Issue:1 Topics: Adult; Blood Pressure; Caffeine; Central Nervous System Stimulants; Combined Modality Therapy; Cross	2013
Caffeine increases aortic stiffness in hypertensive patients. American journal of hypertension, 2003, Volume: 16, Issue:1 Topics: Aorta; Aortic Diseases; Blood Flow Velocity; Caffeine; Cross-Over Studies; Elasticity; Female; Human	2003
Blood pressure response to caffeine shows incomplete tolerance after short-term regular consumption. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:4 Topics: Adult; Blood Pressure; Caffeine; Cross-Over Studies; Double-Blind Method; Drug Administration Schedu	2004
Is an ephedrine caffeine treatment contraindicated in hypertension? International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1997, Volume: 21, Issue:8 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Appetite Depressants; Ca	1997
Acute effects of tea on fasting and postprandial vascular function and blood pressure in humans. Journal of hypertension, 2005, Volume: 23, Issue:1 Topics: Aged; Blood Pressure; Brachial Artery; Caffeine; Central Nervous System Stimulants; Dietary Fats; En	2005
Caffeine and hypertension. The American journal of medicine, 1984, Volume: 77, Issue:1 Topics: Adult; Angiotensins; Blood Pressure; Caffeine; Catecholamines; Clinical Trials as Topic; Double-Blin	1984
Decreased systemic clearance of caffeine due to cimetidine. British journal of clinical pharmacology, 1981, Volume: 12, Issue:2 Topics: Adult; Biological Availability; Caffeine; Cimetidine; Drug Interactions; Female; Guanidines; Humans;	1981
Prolonged increase in blood pressure by a single oral dose of caffeine in mildly hypertensive men. American journal of hypertension, 1994, Volume: 7, Issue:8 Topics: Administration, Oral; Adult; Blood Pressure; Caffeine; Cardiac Output; Cross-Over Studies; Double-Bl	1994
Consistency of cardiovascular response pattern to caffeine across multiple studies using impedance and nuclear cardiography. Biological psychology, 1993, Volume: 36, Issue:1-2 Topics: Administration, Oral; Adult; Blood Pressure; Caffeine; Cardiography, Impedance; Dose-Response Relati	1993
Blood pressure, plasma catecholamine and renin responses to caffeine in elderly hypertensives. Journal of human hypertension, 1993, Volume: 7, Issue:3 Topics: Aged; Aged, 80 and over; Blood Pressure; Caffeine; Catecholamines; Double-Blind Method; Female; Huma	1993
Effect of coffee on ambulatory blood pressure in patients with treated hypertension. Journal of internal medicine, 1993, Volume: 233, Issue:4 Topics: Adult; Aged; Ambulatory Care; Atrial Natriuretic Factor; Blood Pressure; Blood Pressure Determinatio	1993
Acute blood pressure elevations with caffeine in men with borderline systemic hypertension. The American journal of cardiology, 1996, Feb-01, Volume: 77, Issue:4 Topics: Adult; Analysis of Variance; Blood Pressure; Caffeine; Diastole; Humans; Hypertension; Male; Stimula	1996
Interactions between dietary calcium and caffeine consumption on calcium metabolism in hypertensive humans. American journal of hypertension, 1996, Volume: 9, Issue:3 Topics: Administration, Oral; Adult; Aged; Blood Pressure; Caffeine; Calcium; Calcium, Dietary; Creatinine;	1996
Caffeine and behavioral stress effects on blood pressure in borderline hypertensive Caucasian men. Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 1996, Volume: 15, Issue:1 Topics: Adult; Analysis of Variance; Blood Pressure; Caffeine; Central Nervous System Stimulants; Cross-Over	1996
Stress-like adrenocorticotropin responses to caffeine in young healthy men. Pharmacology, biochemistry, and behavior, 1996, Volume: 55, Issue:3 Topics: Administration, Oral; Adrenocorticotropic Hormone; Adult; Caffeine; Central Nervous System Stimulant	1996
Caffeine elevates blood pressure response to exercise in mild hypertensive men. American journal of hypertension, 1995, Volume: 8, Issue:12 Pt 1 Topics: Adult; Blood Pressure; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double-Blind	1995
[Is Letigen contraindicated in hypertension? A double-blind, placebo controlled multipractice study of Letigen administered to normotensive and adequately treated patients with hypersensitivity]. Ugeskrift for laeger, 1998, Jun-29, Volume: 160, Issue:27 Topics: Adult; Aged; Antihypertensive Agents; Appetite Depressants; Blood Pressure; Caffeine; Contraindicati	1998
Additive pressor effects of caffeine and stress in male medical students at risk for hypertension. American journal of hypertension, 2000, Volume: 13, Issue:5 Pt 1 Topics: Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Caffeine; Central Nervous System Stimu	2000
Pressure-altering agents affect central aortic pressures more than is apparent from upper limb measurements in hypertensive patients: the role of arterial wave reflections. Hypertension (Dallas, Tex. : 1979), 2001, Dec-01, Volume: 38, Issue:6 Topics: Aorta; Blood Pressure; Caffeine; Cross-Over Studies; Double-Blind Method; Female; Heart Rate; Hemody	2001
Effects of dietary calcium from dairy products on ambulatory blood pressure in hypertensive men. Journal of the American Dietetic Association, 1992, Volume: 92, Issue:12 Topics: Aged; Blood Pressure; Caffeine; Calcium; Calcium, Dietary; Dairy Products; Diet Records; Humans; Hyp	1992
Caffeine restriction: effect on mild hypertension. BMJ (Clinical research ed.), 1991, Nov-16, Volume: 303, Issue:6812 Topics: Adult; Aged; Blood Pressure; Caffeine; Diet; Female; Humans; Hypertension; Male; Middle Aged	1991
Hypertension risk and caffeine's effect on cardiovascular activity during mental stress in young men. Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 1991, Volume: 10, Issue:4 Topics: Adult; Arousal; Blood Pressure; Caffeine; Double-Blind Method; Exercise Test; Humans; Hypertension;	1991
Effects of caffeine on pressor regulation during rest and exercise in men at risk for hypertension. American heart journal, 1991, Volume: 122, Issue:4 Pt 1 Topics: Adult; Analysis of Variance; Blood Pressure; Caffeine; Double-Blind Method; Humans; Hypertension; Ma	1991
The influence of user status and anxious disposition on the hypertensive effects of caffeine. International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 1990, Volume: 10, Issue:2 Topics: Adult; Anxiety; Blood Pressure; Caffeine; Double-Blind Method; Electromyography; Female; Hand; Heart	1990
Caffeine may potentiate adrenocortical stress responses in hypertension-prone men. Hypertension (Dallas, Tex. : 1979), 1989, Volume: 14, Issue:2 Topics: Adrenocorticotropic Hormone; Adult; Blood Pressure; Caffeine; Humans; Hydrocortisone; Hypertension;	1989
Transient hypertension after two phenylpropanolamine diet aids and the effects of caffeine: a placebo-controlled follow-up study. The American journal of medicine, 1989, Volume: 86, Issue:4 Topics: Adult; Blood Pressure; Caffeine; Double-Blind Method; Drug Interactions; Electrocardiography; Female	1989
Mortality patterns among hypertensives by reported level of caffeine consumption. Preventive medicine, 1988, Volume: 17, Issue:3 Topics: Adult; Aged; Caffeine; Clinical Trials as Topic; Drinking Behavior; Female; Humans; Hypertension; Ma	1988
A double dose of phenylpropanolamine causes transient hypertension. The American journal of medicine, 1988, Volume: 85, Issue:3 Topics: Adult; Blood Pressure; Caffeine; Delayed-Action Preparations; Double-Blind Method; Drug Interactions	1988
Management of essential hypertension. Whom, when and how to treat. Contributions to nephrology, 1987, Volume: 54 Topics: Alcohol Drinking; Antihypertensive Agents; Behavior Therapy; Caffeine; Calcium, Dietary; Clinical Tr	1987

caffeine and Blood Pressure, High

Research Excerpts

Research

Studies (249)

Authors

Clinical Trials (17)

Trial Overview

Trial Outcomes

Number of Participants Who Received the Influenza Vaccine

Reviews

Trials

Other Studies

Authors	Studies
Borghi, C	2
Bragagni, A	1
K Alhabeeb, M	1
M Alazzmi, M	1
S Alrashidi, M	1
Al-Sowayan, NS	1
Berkowsky, RS	1
Zaleski, AL	1
Taylor, BA	1
Chen, MH	1
Gans, KM	1
Wu, Y	1
Parducci, PM	1
Zhang, Y	2
Fernandez, AB	1
Pescatello, LS	1
Han, M	3
Oh, Y	3
Myung, SK	3
Mahdavi, S	1
Palatini, P	4
El-Sohemy, A	1
Alhadi, IA	1
Al Ansari, AM	1
AlSaleh, AFF	1
Alabbasi, AMA	1
Virgili, J	1
Motitis, P	1
Julal, G	1
Mavrommatis, Y	1
Pilic, L	1
Zheng, J	1
Zhu, X	1
Xu, G	1
Wang, X	1
Cao, M	1
Zhu, S	1
Huang, R	1
Zhou, Y	1
Abbas-Hashemi, SA	1
Hosseininasab, D	1
Rastgoo, S	1
Shiraseb, F	1
Asbaghi, O	1
Singh, AP	1
Chandrasekharan, P	1
Gugino, S	1
Berkelhamer, S	1
Wang, H	1
Nielsen, L	1
Kumar, VHS	1
Oboh, G	1
Ojueromi, OO	1
Ademosun, AO	1
Omayone, TP	1
Oyagbemi, AA	1
Ajibade, TO	1
Adedapo, AA	1
Kitano, T	1
Okajima, M	1
Sato, K	1
Noda, T	1
Taniguchi, T	1
Surma, S	1
Oparil, S	1
Bakris, GL	1
Rodríguez-Artalejo, F	3
López-García, E	3
Mattioli, AV	2
Ballerini Puviani, M	1
Farinetti, A	2
James, JE	2
Torres-Collado, L	1
García-de la Hera, M	1
Navarrete-Muñoz, EM	1
Compañ-Gabucio, LM	1
Gonzalez-Palacios, S	1
Vioque, J	1
De Giuseppe, R	1
Di Napoli, I	1
Granata, F	1
Mottolese, A	1
Cena, H	1
Ngueta, G	1
Bennett, JM	1
Rodrigues, IM	1
Klein, LC	1
Siasos, G	1
Oikonomou, E	1
Chrysohoou, C	1
Tousoulis, D	1
Panagiotakos, D	1
Zaromitidou, M	1
Zisimos, K	1
Kokkou, E	1
Marinos, G	1
Papavassiliou, AG	1
Pitsavos, C	1
Stefanadis, C	2
Leroux, MB	1
Lashak, C	1
Mazzurco, M	1
Yeh, TC	1
Liu, CP	1
Cheng, WH	1
Chen, BR	1
Lu, PJ	1
Cheng, PW	1
Ho, WY	1
Sun, GC	1
Liou, JC	1
Tseng, CJ	1
van der Hoeven, N	1
Visser, I	1
Schene, A	1
van den Born, BJ	1
Li, SB	1
Li, YF	1
Mao, ZF	1
Hu, HH	1
Ouyang, SH	1
Wu, YP	1
Tsoi, B	1
Gong, P	1
Kurihara, H	1
He, RR	1
Liantonio, A	1
Camerino, GM	1
Scaramuzzi, A	1
Cannone, M	1
Pierno, S	1
De Bellis, M	1
Conte, E	1
Fraysse, B	1
Tricarico, D	1
Conte Camerino, D	1
Guessous, I	3
Eap, CB	3
Bochud, M	4
Pruijm, M	3
Ponte, B	1
Ackermann, D	1
Ehret, G	2
Ansermot, N	1
Vuistiner, P	1
Staessen, J	1
Gu, Y	1
Paccaud, F	2
Mohaupt, M	1
Vogt, B	1
Pechère-Bertschi, A	2
Pechère-Berstchi, A	1
Martin, PY	1
Burnier, M	3
Benetti, E	1
Mos, L	1
Garavelli, G	1
Mazzer, A	1
Cozzio, S	1
Fania, C	1
Casiglia, E	1
Zimmermann-Viehoff, F	1
Thayer, J	1
Koenig, J	1
Herrmann, C	1
Weber, CS	1
Deter, HC	1
Lopez, DS	1
Wang, R	1
Tsilidis, KK	1
Zhu, H	1
Daniel, CR	1
Sinha, A	1
Canfield, S	1
Mounier-Vehier, C	1
Boudghène, F	1
Claisse, G	1
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Ghassibe-Sabbagh, M	1
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Mouzaya, F	1
Gauguier, D	1
Al-Sarraj, Y	1
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Zalloua, PA	1
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Rhee, JJ	1
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Chang, TI	1
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Stefanick, ML	1
Winkelmayer, WC	2
Orozco-Arbeláez, E	1
Leon-Muñoz, LM	2
Guallar-Castillon, P	1
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Banegas, JR	1
Yu, H	1
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Gao, P	1
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Zhang, H	1
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Lu, Z	1
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Shang, Q	1
Liu, D	1
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Miranda-Ferreira, R	2
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