caffeine and Bilateral Headache studies

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the efficacy of occipital nerve block compared with standard care , defined as acetaminophen with caffeine, for treatment of acute headache in pregnancy."	9.69	Occipital Nerve Block Compared With Acetaminophen and Caffeine for Headache Treatment in Pregnancy: A Randomized Controlled Trial. ( Blanchard, CT; Bushman, ET; Casey, BM; Cozzi, GD; Davis, AM; Digre, KB; Harper, L; Jones, B; Robbins, LS; Sinkey, RG; Szychowski, JM; Tita, AT, 2023)
"To investigate the effects of different doses of oral caffeine-paracetamol combinations in postdural puncture headache (PDPH) prophylaxis."	9.11	Oral multidose caffeine-paracetamol combination is not effective for the prophylaxis of postdural puncture headache. ( Akpinar, H; Esmaoglu, A; Uğur, F, 2005)
"Interruption of daily caffeine consumption can cause caffeine withdrawal headache."	9.08	Perioperative administration of caffeine tablets for prevention of postoperative headaches. ( Drewe, J; Hampl, KF; Rüttimann, U; Schneider, MC; Ummenhofer, W, 1995)
" Using a double-blind placebo-controlled multiple crossover design, 53 patients with non-migrainous headaches were given placebo, acetaminophen, 2 doses of caffeine and 2 combinations of caffeine with acetaminophen."	9.07	The analgesic effects of caffeine in headache. ( Avery, D; Dunner, D; Ward, N; Whitney, C, 1991)
"The contribution of the Fiorinal and codeine phosphate components to the effectiveness of the Fiorinal with Codeine combination in the treatment of tension headache symptoms was evaluated in a randomized, placebo-controlled, multicenter double-blind study."	9.06	Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. ( Boyles, WF; Elkind, AH; Fillingim, J; Ford, RG; Friedman, AP; Gallagher, RM; Hobbs, D; Rapoport, A; Richards, BA; Sheftell, FD, 1988)
"A randomized, double-blind, placebo-controlled, multicenter study was conducted to ascertain the contribution of Fiorinal and codeine phosphate to the efficacy of Fiorinal with Codeine in relieving the pain, tension, and muscle stiffness associated with tension headache."	9.06	Assessment of Fiorinal with Codeine in the treatment of tension headache. ( Friedman, AP, 1986)
"The well-known difficulty in distinguishing the response to a combination headache medication and its individual components in the presence of a high placebo response was again demonstrated in a randomized, double-blind, placebo-controlled, multi-center trial comparing Fiorinal with Codeine and its Fiorinal and codeine phosphate components in relieving the pain, tension, and muscle contraction associated with tension headache."	9.06	Fiorinal with Codeine in the management of tension headache: impact of placebo response. ( Friedman, AP; Hwang, DS; Mietlowski, MJ, 1987)
"Forty postpartum patients with postdural puncture headache (PDPH) were randomly assigned to receive oral caffeine (300 mg) or a placebo."	9.06	Effects of oral caffeine on postdural puncture headache. A double-blind, placebo-controlled trial. ( Camann, WR; Lambert, DH; Murray, RS; Mushlin, PS, 1990)
"A double-blind, randomized, multicenter investigation was conducted to compare the efficacy and safety of Fioricet, acetaminophen with codeine, and placebo for the symptomatic treatment of tension headache."	9.06	Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. ( DiSerio, FJ; Friedman, AP, 1987)
" The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243."	8.90	Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014)
" Most studies used paracetamol or ibuprofen, with 100 mg to 130 mg caffeine, and the most common pain conditions studied were postoperative dental pain, postpartum pain, and headache."	8.88	Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2012)
"Daily caffeine intake/kg body weight and caffeine use disorder are significantly associated with a caffeine-withdrawal headache."	8.31	Prevalence, characteristics, and factors associated with caffeine-withdrawal headache during the first day of Ramadan. ( Al-Azayem, SA; El Desouky, ED; Fathy, W; Hammad, EM; Hussein, M; Magdy, R; Mahfouz, NA; Naguib, EM; Salem, MR, 2023)
"The relationship between current dietary caffeine intake and severe headache or migraine is controversial."	8.31	Association between dietary caffeine intake and severe headache or migraine in US adults. ( Li, J; Liu, Y; Sun, H; Yang, J; Yin, J; Zhang, L, 2023)
"A simple, sensitive, and selective first derivative synchronous fluorimetric method was developed and optimized to track the influence of caffeine content in beverages on the pharmacokinetic parameters of three pharmaceuticals used in relieving headache namely, aspirin (ASP), ibuprofen (IBU), and ergotamine tartrate (ERG)."	8.12	Tracing the influence of caffeine on the pharmacokinetic parameters of three headache relieving pharmaceuticals applying synchronous fluorescence spectroscopy. ( Draz, ME; El Enany, N; El Sherbiny, D; Wahba, MEK, 2022)
"Combinations of analgesics with caffeine have been discussed as bearing a risk for headache chronicity."	7.81	Use of aspirin combinations with caffeine and increasing headache frequency: a prospective population-based study. ( Diener, HC; Geisel, MH; Jöckel, KH; Katsarava, Z; Moebus, S; Obermann, M; Özyurt Kugumcu, M; Schramm, SH; Yoon, MS, 2015)
"The aim of this study was to investigate the association between caffeine consumption and headache type and frequency in the general adult population."	7.75	High dietary caffeine consumption is associated with a modest increase in headache prevalence: results from the Head-HUNT Study. ( Hagen, K; Stovner, LJ; Thoresen, K; Zwart, JA, 2009)
"In connection with the Vågå study of headache epidemiology, a search was made for caffeine-withdrawal headache in 1741 parishioners."	7.72	Caffeine-withdrawal headache. The Vågå study of headache epidemiology. ( Bakketeig, LS; Sjaastad, O, 2004)
"Caffeine dependence is a frequent cause of chronic daily headache."	7.71	[Chronic daily headaches caused by too much caffeine]. ( Schonewille, WJ, 2002)
"Caffeine consumption may cause headache, particularly migraine."	7.69	Influence of caffeine and caffeine withdrawal on headache and cerebral blood flow velocities. ( Couturier, EG; Laman, DM; van Duijn, H; van Duijn, MA, 1997)
"This study examined the hypothesis that headache after general anesthesia is related to a caffeine withdrawal state."	7.68	Is caffeine withdrawal the mechanism of postoperative headache? ( Fennelly, M; Galletly, DC; Purdie, GI, 1991)
"The interruption of daily consumption of caffeine-containing beverages can cause headache and other symptoms within 8 hours."	7.68	Perioperative ingestion of caffeine and postoperative headache. ( Danielson, DR; Ereth, MH; Weber, JG, 1993)
"The abuse of the combination drug containing butalbital 50 mg, aspirin 325 mg and caffeine 40 mg (or BAC), is commonly recognized by headache specialists as causing headaches."	7.68	A protocol for butalbital, aspirin and caffeine (BAC) detoxification in headache patients. ( Sands, GH, 1990)
"In a cross-sectional study of 4558 Australians, it was found that the proportion of subjects reporting indigestion, palpitations, tremor, headache and insomnia increased significantly with mean caffeine intake."	7.67	A study of caffeine consumption and symptoms; indigestion, palpitations, tremor, headache and insomnia. ( Mathers, CD; Shirlow, MJ, 1985)
"This is especially noticeable in migraine."	7.01	Caffeine for Headaches: Helpful or Harmful? A Brief Review of the Literature. ( Cegielska, J; Domitrz, I; Zduńska, A; Zduński, S, 2023)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."	6.55	Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
"To evaluate the efficacy of occipital nerve block compared with standard care , defined as acetaminophen with caffeine, for treatment of acute headache in pregnancy."	5.69	Occipital Nerve Block Compared With Acetaminophen and Caffeine for Headache Treatment in Pregnancy: A Randomized Controlled Trial. ( Blanchard, CT; Bushman, ET; Casey, BM; Cozzi, GD; Davis, AM; Digre, KB; Harper, L; Jones, B; Robbins, LS; Sinkey, RG; Szychowski, JM; Tita, AT, 2023)
"The Thomapyrin Study showed the significant superiority of the fixed combination of acetylsalicylic acid + paracetamol + caffeine over the combination without caffeine, the single preparations, and placebo in the treatment of headache."	5.16	Pain measurement: Visual Analogue Scale (VAS) and Verbal Rating Scale (VRS) in clinical trials with OTC analgesics in headache. ( Aicher, B; Diener, HC; Peil, B; Peil, H, 2012)
"Caffeine is used daily by 85% of United States adults and caffeine withdrawal is a major cause of perioperative headache."	5.12	Caffeine supplementation as part of enhanced recovery after surgery pathways: a narrative review of the evidence and knowledge gaps. ( Johnson, RL; Kopp, SL; Niesen, AD; Pleticha, J, 2021)
"To investigate the effects of different doses of oral caffeine-paracetamol combinations in postdural puncture headache (PDPH) prophylaxis."	5.11	Oral multidose caffeine-paracetamol combination is not effective for the prophylaxis of postdural puncture headache. ( Akpinar, H; Esmaoglu, A; Uğur, F, 2005)
"Interruption of daily caffeine consumption can cause caffeine withdrawal headache."	5.08	Perioperative administration of caffeine tablets for prevention of postoperative headaches. ( Drewe, J; Hampl, KF; Rüttimann, U; Schneider, MC; Ummenhofer, W, 1995)
"To determine whether prophylactic intravenous administration of caffeine, to daily caffeine users, decreases the frequency of postoperative headache and shortens recovery time."	5.08	Prophylactic intravenous administration of caffeine and recovery after ambulatory surgical procedures. ( Arnold, JJ; Danielson, DR; Ereth, MH; Klindworth, JT; Weber, JG, 1997)
" Using a double-blind placebo-controlled multiple crossover design, 53 patients with non-migrainous headaches were given placebo, acetaminophen, 2 doses of caffeine and 2 combinations of caffeine with acetaminophen."	5.07	The analgesic effects of caffeine in headache. ( Avery, D; Dunner, D; Ward, N; Whitney, C, 1991)
"The contribution of the Fiorinal and codeine phosphate components to the effectiveness of the Fiorinal with Codeine combination in the treatment of tension headache symptoms was evaluated in a randomized, placebo-controlled, multicenter double-blind study."	5.06	Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. ( Boyles, WF; Elkind, AH; Fillingim, J; Ford, RG; Friedman, AP; Gallagher, RM; Hobbs, D; Rapoport, A; Richards, BA; Sheftell, FD, 1988)
"A double-blind, randomized, multicenter investigation was conducted to compare the efficacy and safety of Fioricet, acetaminophen with codeine, and placebo for the symptomatic treatment of tension headache."	5.06	Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. ( DiSerio, FJ; Friedman, AP, 1987)
"The well-known difficulty in distinguishing the response to a combination headache medication and its individual components in the presence of a high placebo response was again demonstrated in a randomized, double-blind, placebo-controlled, multi-center trial comparing Fiorinal with Codeine and its Fiorinal and codeine phosphate components in relieving the pain, tension, and muscle contraction associated with tension headache."	5.06	Fiorinal with Codeine in the management of tension headache: impact of placebo response. ( Friedman, AP; Hwang, DS; Mietlowski, MJ, 1987)
"Forty postpartum patients with postdural puncture headache (PDPH) were randomly assigned to receive oral caffeine (300 mg) or a placebo."	5.06	Effects of oral caffeine on postdural puncture headache. A double-blind, placebo-controlled trial. ( Camann, WR; Lambert, DH; Murray, RS; Mushlin, PS, 1990)
"A randomized, double-blind, placebo-controlled, multicenter study was conducted to ascertain the contribution of Fiorinal and codeine phosphate to the efficacy of Fiorinal with Codeine in relieving the pain, tension, and muscle stiffness associated with tension headache."	5.06	Assessment of Fiorinal with Codeine in the treatment of tension headache. ( Friedman, AP, 1986)
"The effect of a new analgesic compound (propoxyphene, acetaminophen, caffeine, hydroxyzine) was investigated in a single-blind study comparing it with plain acetaminophen administered to forty patients with tension headache."	5.04	Study of a new analgesic compound in the treatment of tension headache. ( Borges, J; Zavaleta, C, 1976)
"A patient-assessment of pain relief over 4 hours following a single dose of a compound analgesic has shown that 78% of patients achieve satisfactory relief of pain due to tension headache and that this response is enhanced by the addition of chlormezanone, an agent with reported anxiolytic and muscle relaxant actions."	5.04	A single dose placebo-controlled study to assess the effectiveness of adding a muscle relaxant to a compound analgesic in the treatment of tension headache. ( Atkinson, D, 1979)
"A double-blind, cross-over trial was made of three analgesic preparations--paracetamol, paracetamol with caffeine (Finimal) and aspirin in the relief of postoperative pain in 72 orthopedic inpatients and in 144 ambulatory outpatients suffering form common idiopathic headache."	5.04	A double-blind comparative evaluation of aspirin, paracetamol and paracetamol + caffeine (finimal) for their analgesic effectiveness. ( Lawczyński, L; Olszewska, M; Samochowiec, L; Szwed, G; Wójcicki, J, 1977)
" For hemicrania we used cinnarizine, cyproheptadine, clonidine, histamine, pizotifene and reserpine; for cluster headache, cinnarizine, cyproheptadine, clonidine, histamine and reserpine; for tension headache, cyproheptadine; for psychogenic headache, allylpropylmalonylurea."	5.04	[Therapeutic possibilities in idiopathic headaches. Analysis of 1000 cases (author's transl)]. ( Agostoni, A; Brandi, G; Cottino, A; Gai, V; Gastaldi, L; Lisino, F; Nattero, G, 1975)
" The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243."	4.90	Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014)
" Most studies used paracetamol or ibuprofen, with 100 mg to 130 mg caffeine, and the most common pain conditions studied were postoperative dental pain, postpartum pain, and headache."	4.88	Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2012)
"We considered only English-language articles published in scientific journals and searched for these articles on PubMed using "headache," "fasting," "Yom Kippur," "Ramadan," "hypoglycemia,"and "caffeine withdrawal" as key words, with no limitations to the year of publication."	4.85	Fasting headache: a review of the literature and new hypotheses. ( Bini, A; Castellini, P; Evangelista, A; Lambru, G; Manzoni, GC; Torelli, P, 2009)
"The relationship between current dietary caffeine intake and severe headache or migraine is controversial."	4.31	Association between dietary caffeine intake and severe headache or migraine in US adults. ( Li, J; Liu, Y; Sun, H; Yang, J; Yin, J; Zhang, L, 2023)
"Caffeine consumption is a risk factor for chronic daily headache but few studies have addressed relationships between pediatric patient caffeine levels and headache severity."	4.31	Caffeine consumption as a risk factor for childhood and adolescence migraine. ( Goda, H; Hikita, T; Ito, K; Kudo, T; Ogawa, Y, 2023)
"Daily caffeine intake/kg body weight and caffeine use disorder are significantly associated with a caffeine-withdrawal headache."	4.31	Prevalence, characteristics, and factors associated with caffeine-withdrawal headache during the first day of Ramadan. ( Al-Azayem, SA; El Desouky, ED; Fathy, W; Hammad, EM; Hussein, M; Magdy, R; Mahfouz, NA; Naguib, EM; Salem, MR, 2023)
"A simple, sensitive, and selective first derivative synchronous fluorimetric method was developed and optimized to track the influence of caffeine content in beverages on the pharmacokinetic parameters of three pharmaceuticals used in relieving headache namely, aspirin (ASP), ibuprofen (IBU), and ergotamine tartrate (ERG)."	4.12	Tracing the influence of caffeine on the pharmacokinetic parameters of three headache relieving pharmaceuticals applying synchronous fluorescence spectroscopy. ( Draz, ME; El Enany, N; El Sherbiny, D; Wahba, MEK, 2022)
"A prediction model development study was completed using the 2006 American Migraine Prevalence and Prevention Study survey, from participants who were aged ≥18, met criteria and headache day frequency for episodic migraine, did not take prescription medication for migraine, and used ≥1 of the following acute migraine medication classes: acetaminophen, aspirin, NSAIDs, or caffeine containing combination products (CCP)."	4.12	Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study. ( Armand, CE; Buse, DC; Ezzati, A; Fanning, KM; Lipton, RB; Martin, VT; Pavlovic, JM; Reed, ML, 2022)
" In this study, we also evaluate three "budget" over-the-counter headache medications (subsequently labeled as brands A, B, and C) for agglomeration of the three APIs in the formulation: Acetaminophen, aspirin, and caffeine."	4.02	Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging. ( Dimmitt, NH; Green, AM; Hubbard, ND; Khan, SM; McVey, PA; Taulbee-Cotton, BV; Van Meter, MI; Webster, GK, 2021)
"Combinations of analgesics with caffeine have been discussed as bearing a risk for headache chronicity."	3.81	Use of aspirin combinations with caffeine and increasing headache frequency: a prospective population-based study. ( Diener, HC; Geisel, MH; Jöckel, KH; Katsarava, Z; Moebus, S; Obermann, M; Özyurt Kugumcu, M; Schramm, SH; Yoon, MS, 2015)
" The day before the occurrence of these acute lesions, he self medicated with a drug containing ergotamine and caffeine because of a headache."	3.79	[Digital necrosis in hand by uncommon mechanism]. ( Lashak, C; Leroux, MB; Mazzurco, M, 2013)
"Habitual caffeine consumers who abstain from caffeine experience withdrawal symptoms such as headache, fatigue, difficulty concentrating, mood disturbances, and flu-like symptoms (Juliano and Griffiths, 2004)."	3.78	Development of the caffeine withdrawal symptom questionnaire: caffeine withdrawal symptoms cluster into 7 factors. ( Harrell, PT; Huntley, ED; Juliano, LM; Westerman, AT, 2012)
"The aim of this study was to investigate the association between caffeine consumption and headache type and frequency in the general adult population."	3.75	High dietary caffeine consumption is associated with a modest increase in headache prevalence: results from the Head-HUNT Study. ( Hagen, K; Stovner, LJ; Thoresen, K; Zwart, JA, 2009)
" Self-medication for pain or common cold symptoms was reported by 54% while 8% had taken caffeine tablets or other stimulants."	3.73	Self-medication among Finnish young men in the beginning of common military service. ( Jormanainen, V; Linden, K; Pietilä, K; Swigonski, NL, 2005)
"We described three cases of hypnic headache with successful treatment by lithium carbonate or caffeine."	3.73	[Three Japanese cases of hypnic headache]. ( Burioka, N; Fukuhara, Y; Ishizaki, K; Nakashima, K; Takeshima, T, 2006)
"In connection with the Vågå study of headache epidemiology, a search was made for caffeine-withdrawal headache in 1741 parishioners."	3.72	Caffeine-withdrawal headache. The Vågå study of headache epidemiology. ( Bakketeig, LS; Sjaastad, O, 2004)
"Caffeine dependence is a frequent cause of chronic daily headache."	3.71	[Chronic daily headaches caused by too much caffeine]. ( Schonewille, WJ, 2002)
" She developed post-dural puncture headache (PDPH) on the third postpartum day which was managed by palliative measures: bed rest (patient's position of choice), increased hydration (water: 3 litres po per day), lysine acetyl salicylate (5."	3.70	Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour. ( Agustí, M; Carrero, EJ; Fábregas, N; Fernández, C; Valldeoriola, F, 1998)
"By the example of two case reports, typical signs of caffeine withdrawal like headache, increased irritability, decreased performance and disturbed concentration are described."	3.69	[Episodic headache, diminished performance and depressive mood]. ( Cacciatore, R; Helbling, A; Hess, B; Jost, C, 1996)
"In spite of clinical differences between transformed migraine and tension headache, which may help diagnosis, in our series abuse of analgesics (including ergotamine) was a common characteristic."	3.69	[Clinical features of daily chronic headache]. ( Iñiguez, C; Larrodé, P; Mauri, JA; Morales, F, 1997)
"Caffeine consumption may cause headache, particularly migraine."	3.69	Influence of caffeine and caffeine withdrawal on headache and cerebral blood flow velocities. ( Couturier, EG; Laman, DM; van Duijn, H; van Duijn, MA, 1997)
"This study examined the hypothesis that headache after general anesthesia is related to a caffeine withdrawal state."	3.68	Is caffeine withdrawal the mechanism of postoperative headache? ( Fennelly, M; Galletly, DC; Purdie, GI, 1991)
"The interruption of daily consumption of caffeine-containing beverages can cause headache and other symptoms within 8 hours."	3.68	Perioperative ingestion of caffeine and postoperative headache. ( Danielson, DR; Ereth, MH; Weber, JG, 1993)
"The abuse of the combination drug containing butalbital 50 mg, aspirin 325 mg and caffeine 40 mg (or BAC), is commonly recognized by headache specialists as causing headaches."	3.68	A protocol for butalbital, aspirin and caffeine (BAC) detoxification in headache patients. ( Sands, GH, 1990)
"In a cross-sectional study of 4558 Australians, it was found that the proportion of subjects reporting indigestion, palpitations, tremor, headache and insomnia increased significantly with mean caffeine intake."	3.67	A study of caffeine consumption and symptoms; indigestion, palpitations, tremor, headache and insomnia. ( Mathers, CD; Shirlow, MJ, 1985)
"This is especially noticeable in migraine."	3.01	Caffeine for Headaches: Helpful or Harmful? A Brief Review of the Literature. ( Cegielska, J; Domitrz, I; Zduńska, A; Zduński, S, 2023)
" The most frequent adverse events (AEs) were headache (60 %) and palpitations (40 %)."	2.78	Cardiovascular safety of anagrelide in healthy subjects: effects of caffeine and food intake on pharmacokinetics and adverse reactions. ( Datino, T; Fernández-Avilés, F; Figueiras-Graillet, L; Franklin, R; Gama, JG; Jones, C; Martínez-Sellés, M, 2013)
"Caffeine side effects were evaluated at the end of each trial and 24 h later."	2.78	Neuromuscular responses to incremental caffeine doses: performance and side effects. ( Fernández-Elías, VE; Mora-Rodríguez, R; Muñoz, G; Muñoz-Guerra, J; Ortega, JF; Pallarés, JG, 2013)
"Caffeine did not increase alertness in NL participants."	2.75	Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption. ( Deckert, J; Evershed, RP; Heatherley, SV; Hohoff, C; Maxfield, PJ; Mullings, EL; Nutt, DJ; Rogers, PJ, 2010)
"L-Theanine is an amino acid found naturally in tea."	2.73	The effects of L-theanine, caffeine and their combination on cognition and mood. ( Haskell, CF; Kennedy, DO; Milne, AL; Scholey, AB; Wesnes, KA, 2008)
""Headache" was significantly correlated with amount of money forfeited to avoid placebo."	2.68	Caffeine reinforcement: the role of withdrawal. ( Griffiths, RR; Schuh, KJ, 1997)
"Twenty-two coffee drinkers (three to seven cups per day) underwent repeated double-blind trials to test for caffeine self-administration, withdrawal, and adverse effects."	2.67	Caffeine self-administration, withdrawal, and adverse effects among coffee drinkers. ( Bickel, WK; Fenwick, JW; Gulliver, SB; Higgins, ST; Hughes, JR; Hunt, WK; Mireault, GC, 1991)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."	2.55	Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
"Caffeine is a stimulant of central nervous system and therefore is probably the most commonly used psychoactive substance in the world."	2.48	[Caffeine--common ingredient in a diet and its influence on human health]. ( Wierzejska, R, 2012)
"Caffeine has been an additive in analgesics for many years."	2.41	A benefit-risk assessment of caffeine as an analgesic adjuvant. ( Zhang, WY, 2001)
"Caffeine has a synergistic effectiveness with analgesics."	2.41	Do caffeine-containing analgesics promote dependence? A review and evaluation. ( Dalessio, D; Feinstein, AR; Fox, JM; Goldstein, J; Haag, G; Heinemann, LA; Ladewig, D; O'Brien, CP, 2000)
" Long term use produces tolerance to some of the pharmacological effects."	2.39	Pharmacological rationale for the clinical use of caffeine. ( Sawynok, J, 1995)
"Chronic cluster headache (CCH) is a rare but severely debilitating primary headache condition."	1.91	Treatment of chronic cluster headache with burst and tonic occipital nerve stimulation: A case series. ( Fogh-Andersen, IS; Jensen, RH; Knudsen, AL; Meier, K; Sørensen, JCH, 2023)
"Headache is a prevalent, debilitating condition that affects 50% of adults globally."	1.72	Student pharmacist characteristics and management of headache. ( Axon, DR; Dawid, A, 2022)
"Prochlorperazine injection has been upgraded to a highly recommended level because of the rich clinical experience for this treatment."	1.72	2022 Taiwan Guidelines for Acute Treatment of Migraine. ( Lau, CI; Wang, YF, 2022)
"In total, the participants reported 825 migraines during 4467 days of observation."	1.51	Prospective Cohort Study of Caffeinated Beverage Intake as a Potential Trigger of Headaches among Migraineurs. ( Bertisch, SM; Buettner, C; Li, W; Mittleman, MA; Mostofsky, E, 2019)
"Caffeine was the most common implicated trigger (28), followed by monosodium glutamate (25), cocoa (22), aspartame (13), cheese (13), citrus (10) and nitrites (six)."	1.46	Effect of exclusion of frequently consumed dietary triggers in a cohort of children with chronic primary headache. ( Taheri, S, 2017)
"Hypnic headache is an infrequent type of primary headache characterised by appearing almost exclusively during sleep and by waking the patient up."	1.38	[Description of a series of cases of hypnic headache. Differentiation between sexes]. ( Casado-Naranjo, I; Gámez-Leyva, G; Gómez, M; Jiménez-Caballero, PE, 2012)
" In contrast to acute renal insufficiency that may already occur after a single NSAID dose, analgesic nephropathy is a disease caused by long-term intake of NSAID compound analgesics and predominantly affects the middle and old age."	1.33	[Chronic interstitial nephritis in an 18-year-old due to intake of a compound analgesic]. ( Janssen, U; Jochum, E, 2006)
"Headache is a common and distressing morbidity associated with day case surgery."	1.32	Perioperative headache and day case surgery. ( Buggy, DJ; Gill, PS; Guest, C; Rabey, PG, 2003)
"Prevalence of headache, stomachache, backache, and morning fatigue."	1.32	Headache, stomachache, backache, and morning fatigue among adolescent girls in the United States: associations with behavioral, sociodemographic, and environmental factors. ( Ghandour, RM; Huang, ZJ; Kogan, MD; Overpeck, MD; Scheidt, PC, 2004)
"The headaches were treated with chlorpromazine with a good result."	1.30	[Intractable vomiting, convulsions and megaloblastic anemia: anamnesis, key to diagnosis]. ( de Torrenté, A; Humair, L; Schlaeppi, M, 1999)
"Caffeine did not increase the severity of symptoms but did decrease the severity of withdrawal-induced hunger."	1.28	Effects of caffeine on tobacco withdrawal. ( Bickel, WK; Fenwick, JW; Higgins, ST; Hughes, JR; Oliveto, AH; Pepper, SL; Terry, SY, 1991)
"Caffeine was contained in at least one drug in all cases, ergotamine in 80."	1.28	Longterm prognosis of analgesic withdrawal in patients with drug-induced headaches. ( Baumgartner, C; Bingöl, C; Holzner, F; Maly, J; Wessely, P, 1989)
"The long-term effects of substance abuse are contingent on the compounds that are used."	1.28	Drug abuse and headache. ( Elkind, AH, 1991)

Research

Studies (235)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Duration of Headache Free Period at 7 Days

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 28 Days

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 7 Days

Number of Participants With Injection Site Complication (Infection, Hematoma, and Ecchymosis)

Number of Participants With Need for Admission for Treatment of Headache

Number of Participants With Need for Crossover Treatment

Number of Participants With Need for Neurology Consult

Number of Participants With Need for Representation for Treatment of Headache With 28 Days

Timeframe	Studies, this research(%)	All Research%
pre-1990	110 (46.81)	18.7374
1990's	47 (20.00)	18.2507
2000's	36 (15.32)	29.6817
2010's	26 (11.06)	24.3611
2020's	16 (6.81)	2.80

Authors	Studies
Musafia, B	1
Rosenberg, G	1
Ezzati, A	1
Fanning, KM	1
Buse, DC	1
Pavlovic, JM	1
Armand, CE	1
Reed, ML	1
Martin, VT	1
Lipton, RB	2
Wahba, MEK	1
El Sherbiny, D	1
El Enany, N	1
Draz, ME	1
Lau, CI	1
Wang, YF	1
Axon, DR	1
Dawid, A	1
Hikita, T	3
Goda, H	3
Ogawa, Y	3
Kudo, T	3
Ito, K	3
Bashatah, AS	1
Syed, W	1
Al-Rawi, MBA	1
Al Arifi, MN	1
Magdy, R	1
El Desouky, ED	1
Hammad, EM	1
Salem, MR	1
Mahfouz, NA	1
Fathy, W	1
Al-Azayem, SA	1
Naguib, EM	1
Hussein, M	1
Zhang, L	1
Yin, J	1
Li, J	1
Sun, H	1
Liu, Y	1
Yang, J	1
Zduńska, A	1
Cegielska, J	1
Zduński, S	1
Domitrz, I	1
Fogh-Andersen, IS	1
Sørensen, JCH	1
Jensen, RH	1
Knudsen, AL	1
Meier, K	1
Bushman, ET	1
Blanchard, CT	1
Cozzi, GD	1
Davis, AM	1
Harper, L	1
Robbins, LS	1
Jones, B	1
Szychowski, JM	1
Digre, KB	1
Casey, BM	1
Tita, AT	1
Sinkey, RG	1
Mostofsky, E	1
Mittleman, MA	1
Buettner, C	1
Li, W	1
Bertisch, SM	1
Chattha, N	1
Webb, T	1
Hargroves, D	1
Balogun, I	1
Bertoni, M	1
Van Meter, MI	1
Khan, SM	1
Taulbee-Cotton, BV	1
Dimmitt, NH	1
Hubbard, ND	1
Green, AM	1
Webster, GK	1
McVey, PA	1
Pleticha, J	1
Niesen, AD	1
Kopp, SL	1
Johnson, RL	1
Aoun, MH	1
Hilal, N	1
Beaini, C	1
Sleilaty, G	1
Hajal, J	1
Boueri, C	1
Chelala, D	1
Bright, M	1
Raman, V	1
Laupland, KB	1
Diener, HC	3
Robbins, MS	1
Garas, SY	1
Patel, K	1
Rath, S	1
Shaikh, A	1
Narwal, P	1
Gupta, A	1
Khairoalsindi, OA	1
Saber, WK	1
Althubaiti, NA	1
Alshareef, EF	1
Almekhlafi, MA	1
Pallarés, JG	1
Fernández-Elías, VE	1
Ortega, JF	1
Muñoz, G	1
Muñoz-Guerra, J	1
Mora-Rodríguez, R	1
Leroux, MB	1
Lashak, C	1
Mazzurco, M	1
Derry, CJ	2
Derry, S	2
Moore, RA	2
Schramm, SH	1
Moebus, S	1
Özyurt Kugumcu, M	1
Geisel, MH	1
Obermann, M	1
Yoon, MS	1
Jöckel, KH	1
Katsarava, Z	2
Lara, B	1
Ruiz-Vicente, D	1
Areces, F	1
Abián-Vicén, J	1
Salinero, JJ	1
Gonzalez-Millán, C	1
Gallo-Salazar, C	1
Del Coso, J	1
Koivusilta, L	1
Kuoppamäki, H	1
Rimpelä, A	1
Taheri, S	1
Sohn, RS	1
Shapiro, RE	1
Ortiz, GA	1
Bianchi, NA	1
Tiede, MP	1
Bhatia, RG	1
Hagen, K	1
Thoresen, K	1
Stovner, LJ	1
Zwart, JA	1
Nikić, PM	1
Zidverc-Trajković, J	1
Andrić, B	1
Milinković, M	1
Stojimirović, B	1
Torelli, P	1
Evangelista, A	1
Bini, A	1
Castellini, P	1
Lambru, G	1
Manzoni, GC	1
Rogers, PJ	3
Hohoff, C	1
Heatherley, SV	2
Mullings, EL	1
Maxfield, PJ	1
Evershed, RP	1
Deckert, J	1
Nutt, DJ	1
Scher, A	1
Lipton, R	1
Bigal, M	1
Burtscher, M	1
Mairer, K	1
Wille, M	1
Broessner, G	1
Farahmand, N	1
Drennan, D	1
Junkins, S	1
Zadoyan, G	1
Rokitta, D	1
Klement, S	1
Dienel, A	1
Hoerr, R	1
Gramatté, T	1
Fuhr, U	1
Aicher, B	1
Peil, H	1
Peil, B	1
Juliano, LM	1
Huntley, ED	1
Harrell, PT	1
Westerman, AT	1
Jiménez-Caballero, PE	1
Gámez-Leyva, G	1
Gómez, M	1
Casado-Naranjo, I	1
Hunter, BR	1
Seupaul, RA	1
Stendell, L	1
Fomsgaard, JS	1
Olsen, KS	1
Hurlock, L	1
Lee, MG	1
Wierzejska, R	1
Martínez-Sellés, M	1
Datino, T	1
Figueiras-Graillet, L	1
Gama, JG	1
Jones, C	1
Franklin, R	1
Fernández-Avilés, F	1
Oliver, A	1
Spencer, B	1
Schonewille, WJ	1
Abe, M	1
Kumagi, T	1
Nakanishi, S	1
Yamagami, T	1
Michitaka, K	1
Abe, K	1
Okura, I	1
Yamashita, H	1
Horiike, N	1
Onji, M	1
Hering-Hanit, R	1
Gadoth, N	1
Gill, PS	1
Guest, C	1
Rabey, PG	1
Buggy, DJ	1
Yildirim, RC	1
MOYER, JH	1
TASHNEK, AB	1
MILLER, SI	1
SNYDER, H	1
BOWMAN, RO	1
VERDEAU, J	1
RYAN, RE	7
PIGUET, G	1
MILLEN, FJ	1
McGOOGAN, LS	1
HORNER, GM	1
PICHLER, E	1
MAHNERT, E	1
MONTALDI, M	1
WITTICH, FW	1
GERHARD, JP	1
MAZOUE, F	1
BLUMENTHAL, LS	4
FUCHS, M	4
PIEGAJA, D	1
EKBOM, KA	1
WALCHER, W	1
DOMZAL, T	2
MARTINS, JK	1
FRIEDMAN, AP	5
DALSGAARD-NIELSEN, T	1
SZIRMAI, E	1
MILLER, JL	1
GABKA, J	1
SCHNEIDER, E	1
MOELLHOFF, G	1
DANFORTH, HB	1
KUNKLE, EC	1
SICUTERI, F	1
FRANCHI, G	1
MONCKTON, G	1
WARNER, RS	1
GRAHAM, JR	1
RAMSAY, AG	1
WHITE, DF	1
GOLDSTEIN, A	1
YOUNG, JV	1
HAYDON, GB	1
GRAY, CP	1
HECKER, SP	1
LEE, PR	1
REEVES, JE	1
SHOFSTALL, CK	1
SHOFSTALL, WH	1
Sjaastad, O	1
Bakketeig, LS	1
Ghandour, RM	1
Overpeck, MD	1
Huang, ZJ	1
Kogan, MD	1
Scheidt, PC	1
Jafri, SH	1
Cook, JW	1
Reed, RR	1
Beebe, DK	1
Fritsche, G	1
COHEN, SG	1
CRIEP, LH	1
WHITELAW, MJ	1
Linden, K	1
Jormanainen, V	1
Swigonski, NL	1
Pietilä, K	1
Maizels, M	1
Esmaoglu, A	1
Akpinar, H	1
Uğur, F	1
Stafford, LD	1
Yeomans, MR	1
Hancock, KM	1
Fukuhara, Y	1
Takeshima, T	1
Ishizaki, K	1
Burioka, N	1
Nakashima, K	1
Steiner, TJ	2
Jochum, E	1
Janssen, U	1
Tfelt-Hansen, P	1
Dooley, JM	1
Gordon, KE	1
Wood, EP	1
Brna, PM	1
MacSween, J	1
Fraser, A	1
Haskell, CF	1
Kennedy, DO	1
Milne, AL	1
Wesnes, KA	1
Scholey, AB	1
HILSINGER, RL	1
Müller, WK	1
MacNeal, PS	1
Laska, EM	1
Sunshine, A	1
Mueller, F	1
Elvers, WB	1
Siegel, C	1
Rubin, A	1
Peters, KS	1
Seltzer, S	1
Harrington, TM	1
Greden, JF	2
Domino, L	1
Victor, BS	1
Fontaine, P	1
Lubetsky, M	1
Hampl, KF	2
Schneider, MC	2
Rüttimann, U	1
Ummenhofer, W	1
Drewe, J	1
Engel, C	1
Sawynok, J	1
Kueper, T	1
Martinelli, D	1
Konetzki, W	1
Stamerjohn, RW	1
Magill, JB	1
Höfer, I	1
Bättig, K	1
Nikolajsen, L	1
Larsen, KM	1
Kierkegaard, O	1
Crosby, E	1
Stotz, G	1
Mauskop, A	2
Altura, BT	1
Cracco, RQ	1
Altura, BM	1
Cerrato, PL	1
Weber, JG	2
Ereth, MH	2
Danielson, DR	2
Harper, JV	1
Richardson, NJ	1
Elliman, NA	1
O'Dell, RJ	1
Smith, AP	1
Cacciatore, R	1
Helbling, A	1
Jost, C	1
Hess, B	1
Schuh, KJ	1
Griffiths, RR	4
Couturier, EG	1
Laman, DM	1
van Duijn, MA	1
van Duijn, H	1
Beine, S	1
Verwied, SC	1
Lührmann, PM	1
Klindworth, JT	1
Arnold, JJ	1
Iñiguez, C	1
Larrodé, P	1
Mauri, JA	1
Morales, F	1
Shea, PE	1
Mannix, LK	1
Frame, JR	1
Solomon, GD	1
Daghfous, M	1
Ben Khalifa, S	1
Lebbène, I	1
Ferjani, M	1
Moakhar, R	1
Dhahri, M	1
Dodick, DW	1
Mosek, AC	1
Campbell, JK	1
James, JE	1
Carrero, EJ	1
Agustí, M	1
Fábregas, N	1
Valldeoriola, F	1
Fernández, C	1
Van de Velde, M	1
Corneillie, M	1
Vanacker, B	1
Stevens, E	1
Verhaeghe, J	1
Van Assche, A	1
Vandermeersch, E	1
Schlaeppi, M	1
Humair, L	1
de Torrenté, A	1
Feikema, WJ	1
Spierings, EL	1
Carrera González, A	1
Sanz, F	1
de la Calle, B	1
Laustalet de la Fuente, J	1
Feinstein, AR	1
Heinemann, LA	1
Dalessio, D	1
Fox, JM	1
Goldstein, J	1
Haag, G	1
Ladewig, D	1
O'Brien, CP	1
Vincent, S	1
Aboff, B	1
Zhang, WY	1
Lin, W	1
Geiderman, J	1
Kovacs, EM	1
Martin, AM	1
Brouns, F	1
Moral Turiel, M	1
Rodríguez Simón, MO	1
Sahagún de la Lastra, J	1
Yuste Pascual, JA	1
Pieschl, D	1
Angersbach, P	1
Babej, E	1
Bollmann, H	1
Glaser, A	1
Kolbe, M	1
von Seck, P	1
Schulze, H	1
Heyck, H	1
Fanchamps, A	1
Shorofsky, MA	1
Lamm, RN	1
Wójcicki, J	1
Samochowiec, L	1
Lawczyński, L	1
Szwed, G	1
Olszewska, M	1
van Graffenried, B	1
Hill, RC	1
Kagan, G	1
Masheter, HC	1
Atkinson, D	1
Pakes, GE	1
Borges, J	1
Zavaleta, C	1
Nattero, G	3
Agostoni, A	1
Brandi, G	1
Cottino, A	1
Gai, V	3
Gastaldi, L	3
Lisino, F	1
Eentges, RT	1
Vogl, P	1
Nick, JB	1
Mann, KV	1
Temple, AR	1
Ward, NMD	1
Silverman, K	1
Evans, SM	1
Strain, EC	1
Hering, R	1
Harlan, M	1
Davey, R	1
Oliveto, AH	1
Hughes, JR	2
Terry, SY	1
Bickel, WK	2
Higgins, ST	2
Pepper, SL	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Coffee Intake in HemoDialysis and Headache (CoffeeHD): a Randomized Double Blind Multicenter Clinical Trial[NCT04057313]		156 participants (Actual)	Interventional	2019-09-01	Completed
CaffeinICU Study - A Randomized Controlled Multi-centre Pilot Study, on the Efficacy of Oral Caffeine, in Reducing the Duration of Mechanical Ventilation in Critically Ill Adult Patients[NCT05232734]	Phase 2	30 participants (Anticipated)	Interventional	2022-11-24	Recruiting
Acute Headache Treatment in Pregnancy: Improvement in Pain Scores With Occipital Nerve Block vs PO Acetaminophen With Caffeine A Randomized Controlled Trial[NCT03951649]	Phase 4	62 participants (Actual)	Interventional	2020-02-10	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	days (Median)
Occipital Nerve Block	6
Oral Acetaminophen/Caffeine Group	1

Intervention	Participants (Count of Participants)
Occipital Nerve Block	9
Oral Acetaminophen/Caffeine Group	4

Intervention	Participants (Count of Participants)
Occipital Nerve Block	7
Oral Acetaminophen/Caffeine Group	2

Intervention	Participants (Count of Participants)
Occipital Nerve Block	0
Oral Acetaminophen/Caffeine Group	2

Intervention	Participants (Count of Participants)
Occipital Nerve Block	0
Oral Acetaminophen/Caffeine Group	0

Intervention	Participants (Count of Participants)
Occipital Nerve Block	9
Oral Acetaminophen/Caffeine Group	14

Intervention	Participants (Count of Participants)
Occipital Nerve Block	4
Oral Acetaminophen/Caffeine Group	2

Emergency department for treatment of headache since treatment asked at 28 day follow up (NCT03951649)
Timeframe: 28 days

Number of Participants With Need for Second Line Treatment

Number of Participants With Response to Occipital Nerve Block in Pregnancy

Intervention	Participants (Count of Participants)
Occipital Nerve Block	5
Oral Acetaminophen/Caffeine Group	1

Intervention	Participants (Count of Participants)
Occipital Nerve Block	5
Oral Acetaminophen/Caffeine Group	5

Based on guidelines from the International Headache Society the primary outcome is the portion of women who experience resolution of headache or improvement of headache to mild range (VRS ≤ 3) at 2 hours following treatment with Occipital nerve block as compared to acetaminophen/caffeine cocktail. (NCT03951649)
Timeframe: 60-300 min

Response to Cross Over Treatment at 60 Min

Intervention	Participants (Count of Participants)
Occipital Nerve Block	20
Oral Acetaminophen/Caffeine Group	16

"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 60 min

Response to Second Line Treatment at 60 Min

Intervention	score on a scale (Median)
Occipital Nerve Block	6
Oral Acetaminophen/Caffeine Group	3

Response to Treatment Within 2 Hours

Article	Year
Caffeine for Headaches: Helpful or Harmful? A Brief Review of the Literature. Nutrients, 2023, Jul-17, Volume: 15, Issue:14 Topics: Caffeine; Headache; Humans; Migraine Disorders	2023
Caffeine supplementation as part of enhanced recovery after surgery pathways: a narrative review of the evidence and knowledge gaps. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2021, Volume: 68, Issue:6 Topics: Adult; Caffeine; Coffee; Dietary Supplements; Enhanced Recovery After Surgery; Headache; Humans	2021
Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review. BMC anesthesiology, 2021, 03-31, Volume: 21, Issue:1 Topics: Anesthesia Recovery Period; Caffeine; Central Nervous System Stimulants; Critical Care; Headache; Hu	2021
Caffeine in the management of patients with headache. The journal of headache and pain, 2017, Oct-24, Volume: 18, Issue:1 Topics: Abdominal Pain; Acetaminophen; Adult; Analgesics; Aspirin; Caffeine; Central Nervous System Stimulan	2017
Caffeine as an analgesic adjuvant for acute pain in adults. The Cochrane database of systematic reviews, 2014, Dec-11, Issue:12 Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics; Caffeine; Chemotherapy, Adjuvant; Di	2014
Caffeine and headaches. Current pain and headache reports, 2008, Volume: 12, Issue:4 Topics: Caffeine; Headache; Headache Disorders, Secondary; Humans; Substance Withdrawal Syndrome	2008
Fasting headache: a review of the literature and new hypotheses. Headache, 2009, Volume: 49, Issue:5 Topics: Caffeine; Causality; Fasting; Food Deprivation; Headache; Homeostasis; Humans; Hypoglycemia; Religio	2009
Caffeine as an analgesic adjuvant for acute pain in adults. The Cochrane database of systematic reviews, 2012, Mar-14, Issue:3 Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Caffeine; Chemotherapy, Adjuvant; Female; Headache; Hu	2012
Are there pharmacologic agents that safely and effectively treat post-lumbar puncture headache? Annals of emergency medicine, 2013, Volume: 61, Issue:1 Topics: Adrenocorticotropic Hormone; Caffeine; Central Nervous System Stimulants; Headache; Humans; Injectio	2013
[Caffeine--common ingredient in a diet and its influence on human health]. Roczniki Panstwowego Zakladu Higieny, 2012, Volume: 63, Issue:2 Topics: Adolescent; Adult; Brain; Caffeine; Cardiovascular Diseases; Central Nervous System Stimulants; Chil	2012
Dural punctures in children: what should we do? Paediatric anaesthesia, 2002, Volume: 12, Issue:6 Topics: Adolescent; Analgesics; Anesthesia, Epidural; Bed Rest; Blood Patch, Epidural; Caffeine; Child; Dura	2002
[Gordian knot: medication overuse headache]. Schmerz (Berlin, Germany), 2004, Volume: 18, Issue:5 Topics: Analgesics; Caffeine; Codeine; Drug Therapy, Combination; Headache; Humans; Narcotics	2004
Foods, and food and drug combinations, responsible for head and neck pain. Cephalalgia : an international journal of headache, 1982, Volume: 2, Issue:2 Topics: Adult; Alcoholic Beverages; Amygdalin; Cacao; Caffeine; Child; Chronic Disease; Cluster Headache; Dr	1982
Pharmacological rationale for the clinical use of caffeine. Drugs, 1995, Volume: 49, Issue:1 Topics: Animals; Apnea; Caffeine; Central Nervous System; Headache; Humans; Hypotension; Obesity; Pain; Phos	1995
[Treatment of headaches following dura mater puncture]. La Tunisie medicale, 1996, Volume: 74, Issue:11 Topics: Adult; Aged; Analgesics; Anesthesia, Obstetrical; Anesthesia, Spinal; Blood Patch, Epidural; Caffein	1996
[Headache and chronic sleep deprivation: an often missed relationship in children and also in adults]. Nederlands tijdschrift voor geneeskunde, 1999, Sep-18, Volume: 143, Issue:38 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Caffeine; Central Nervous System Stimulants; Child; Ch	1999
Do caffeine-containing analgesics promote dependence? A review and evaluation. Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:5 Topics: Analgesics; Caffeine; Drug Synergism; Evidence-Based Medicine; Headache; Humans; Phenacetin; Substan	2000
A benefit-risk assessment of caffeine as an analgesic adjuvant. Drug safety, 2001, Volume: 24, Issue:15 Topics: Adjuvants, Pharmaceutic; Analgesics; Animals; Caffeine; Drug Antagonism; Female; Headache; Headache	2001
[Classification, pathogenesis and drug therapy of migraine and related forms of headache]. Die Medizinische Welt, 1975, Aug-29, Volume: 6, Issue:35 Topics: Adrenergic beta-Antagonists; Animals; Caffeine; Clonidine; Dihydroergotamine; Drug Synergism; Epinep	1975
Propoxyphene hydrochloride. A critical review. JAMA, 1970, Aug-10, Volume: 213, Issue:6 Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headac	1970

Article	Year
Occipital Nerve Block Compared With Acetaminophen and Caffeine for Headache Treatment in Pregnancy: A Randomized Controlled Trial. Obstetrics and gynecology, 2023, Nov-01, Volume: 142, Issue:5 Topics: Acetaminophen; Anesthetics, Local; Caffeine; Female; Headache; Humans; Infant, Newborn; Nerve Block;	2023
Effects of Caffeinated and Decaffeinated Coffee on Hemodialysis-Related Headache (CoffeeHD): A Randomized Multicenter Clinical Trial. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2021, Volume: 31, Issue:6 Topics: Caffeine; Coffee; Double-Blind Method; Headache; Humans; Renal Dialysis	2021
Neuromuscular responses to incremental caffeine doses: performance and side effects. Medicine and science in sports and exercise, 2013, Volume: 45, Issue:11 Topics: Adult; Athletic Performance; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double	2013
Acute consumption of a caffeinated energy drink enhances aspects of performance in sprint swimmers. The British journal of nutrition, 2015, Sep-28, Volume: 114, Issue:6 Topics: Adolescent; Adult; Athletes; Athletic Performance; Caffeine; Double-Blind Method; Energy Drinks; Exe	2015
Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:9 Topics: Adult; Anxiety; Arousal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Dr	2010
Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers. European journal of clinical pharmacology, 2012, Volume: 68, Issue:5 Topics: Adult; Biotransformation; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochro	2012
Pain measurement: Visual Analogue Scale (VAS) and Verbal Rating Scale (VRS) in clinical trials with OTC analgesics in headache. Cephalalgia : an international journal of headache, 2012, Volume: 32, Issue:3 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Area Under Curve; Aspirin; Caffeine; Drug Combin	2012
Cardiovascular safety of anagrelide in healthy subjects: effects of caffeine and food intake on pharmacokinetics and adverse reactions. Clinical drug investigation, 2013, Volume: 33, Issue:1 Topics: Adolescent; Adult; Analysis of Variance; Area Under Curve; Arrhythmias, Cardiac; Biotransformation;	2013
Oral multidose caffeine-paracetamol combination is not effective for the prophylaxis of postdural puncture headache. Journal of clinical anesthesia, 2005, Volume: 17, Issue:1 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthesia, Spinal; Caffeine; Central Nervous System	2005
Caffeine deprivation state modulates coffee consumption but not attentional bias for caffeine-related stimuli. Behavioural pharmacology, 2005, Volume: 16, Issue:7 Topics: Adolescent; Adult; Affect; Attention; Caffeine; Central Nervous System Stimulants; Coffee; Cognition	2005
Psychostimulant and other effects of caffeine in 9- to 11-year-old children. Journal of child psychology and psychiatry, and allied disciplines, 2006, Volume: 47, Issue:2 Topics: Affect; Arousal; Attention; Caffeine; Central Nervous System Stimulants; Child; Cognition; Dose-Resp	2006
Caffeine as an adjuvant to ibuprofen in treating childhood headaches. Pediatric neurology, 2007, Volume: 37, Issue:1 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Central Nervous System Stimulants; Ch	2007
The effects of L-theanine, caffeine and their combination on cognition and mood. Biological psychology, 2008, Volume: 77, Issue:2 Topics: Adolescent; Adult; Affect; Attention; Caffeine; Central Nervous System Stimulants; Cognition; Cross-	2008
[Experiences with the broad spectrum analgesic Montamed in practice]. Wiener medizinische Wochenschrift (1946), 1966, Oct-29, Volume: 116, Issue:44 Topics: Analgesics; Animals; Brachial Plexus Neuritis; Caffeine; Colic; Dysmenorrhea; Female; Guinea Pigs; H	1966
Caffeine as an analgesic adjuvant. JAMA, 1984, Apr-06, Volume: 251, Issue:13 Topics: Acetaminophen; Adjuvants, Pharmaceutic; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Dou	1984
Perioperative administration of caffeine tablets for prevention of postoperative headaches. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:9 Topics: Adult; Aged; Caffeine; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged; Postoperati	1995
Cardiovascular, behavioral, and subjective effects of caffeine under field conditions. Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:4 Topics: Adult; Arousal; Behavior; Blood Pressure; Caffeine; Female; Headache; Heart Rate; Hemodynamics; Huma	1994
Mood and performance effects of caffeine in relation to acute and chronic caffeine deprivation. Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:2 Topics: Acute Disease; Adolescent; Adult; Affect; Anger; Caffeine; Central Nervous System Stimulants; Chroni	1995
Caffeine reinforcement: the role of withdrawal. Psychopharmacology, 1997, Volume: 130, Issue:4 Topics: Adult; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Female; Headache; Humans; M	1997
Coffee consumption and total body water homeostasis as measured by fluid balance and bioelectrical impedance analysis. Annals of nutrition & metabolism, 1997, Volume: 41, Issue:1 Topics: Adult; Blood Circulation; Body Water; Body Weight; Caffeine; Coffee; Diuresis; Female; Headache; Hom	1997
Prophylactic intravenous administration of caffeine and recovery after ambulatory surgical procedures. Mayo Clinic proceedings, 1997, Volume: 72, Issue:7 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Caffeine; Central Nervous System Stimulants; Coffee; Dou	1997
Acute and chronic effects of caffeine on performance, mood, headache, and sleep. Neuropsychobiology, 1998, Volume: 38, Issue:1 Topics: Acute Disease; Affect; Analysis of Variance; Caffeine; Chi-Square Distribution; Chronic Disease; Cro	1998
The effect of ad libitum ingestion of a caffeinated carbohydrate-electrolyte solution on urinary caffeine concentration after 4 hours of endurance exercise. International journal of sports medicine, 2002, Volume: 23, Issue:4 Topics: Adult; Beverages; Caffeine; Carbohydrates; Dizziness; Doping in Sports; Drinking; Electrolytes; Eruc	2002
[Combined study of Silentan. Test of a headache remedy in general and clinical practice]. MMW, Munchener medizinische Wochenschrift, 1979, Mar-09, Volume: 121, Issue:10 Topics: Adult; Aspirin; Caffeine; Clinical Trials as Topic; Diazepam; Dihydroergotamine; Double-Blind Method	1979
A double-blind comparative evaluation of aspirin, paracetamol and paracetamol + caffeine (finimal) for their analgesic effectiveness. Archivum immunologiae et therapiae experimentalis, 1977, Volume: 25, Issue:2 Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Clinical Trials as Topic; Drug Therapy, C	1977
Headache as a model for testing mild analgesics. Research and clinical studies in headache, 1978, Volume: 6 Topics: Adult; Aminopyrine; Analgesics; Antipyrine; Aspirin; Barbiturates; Caffeine; Clinical Trials as Topi	1978
A controlled study of short-term treatment of tension headache. Current medical research and opinion, 1978, Volume: 5, Issue:9 Topics: Acetaminophen; Adult; Analgesics; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method;	1978
A single dose placebo-controlled study to assess the effectiveness of adding a muscle relaxant to a compound analgesic in the treatment of tension headache. The Journal of international medical research, 1979, Volume: 7, Issue:6 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Caffeine; Chlormezanone; Clinical Trials as Topi	1979
Study of a new analgesic compound in the treatment of tension headache. The Journal of international medical research, 1976, Volume: 4, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Caffeine; Clinical Trials as Topic; Dextropropox	1976
[Therapeutic possibilities in idiopathic headaches. Analysis of 1000 cases (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1975, Sep-19, Volume: 117, Issue:38 Topics: Aspirin; Caffeine; Cinnarizine; Clinical Trials as Topic; Clonidine; Cyproheptadine; Drug Therapy, C	1975
Withdrawal syndrome after the double-blind cessation of caffeine consumption. The New England journal of medicine, 1992, Oct-15, Volume: 327, Issue:16 Topics: Adult; Caffeine; Depression; Diet; Double-Blind Method; Female; Headache; Humans; Interview, Psychol	1992
Abrupt outpatient withdrawal of medication in analgesic-abusing migraineurs. Lancet (London, England), 1991, Jun-15, Volume: 337, Issue:8755 Topics: Adult; Amitriptyline; Analgesics; Caffeine; Ergotamine; Evaluation Studies as Topic; Female; Follow-	1991
Headache pain model for assessing and comparing the efficacy of over-the-counter analgesic agents. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:3 Topics: Acetaminophen; Adult; Analgesics; Aspirin; Caffeine; Double-Blind Method; Drug Combinations; Drug Ev	1991
The analgesic effects of caffeine in headache. Pain, 1991, Volume: 44, Issue:2 Topics: Acetaminophen; Adolescent; Adult; Affect; Caffeine; Double-Blind Method; Drug Combinations; Female;	1991
Caffeine self-administration, withdrawal, and adverse effects among coffee drinkers. Archives of general psychiatry, 1991, Volume: 48, Issue:7 Topics: Adult; Caffeine; Coffee; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged; Self Medi	1991
Effects of oral caffeine on postdural puncture headache. A double-blind, placebo-controlled trial. Anesthesia and analgesia, 1990, Volume: 70, Issue:2 Topics: Administration, Oral; Adult; Benzoates; Benzoic Acid; Caffeine; Cerebrovascular Circulation; Double-	1990
Fiorinal with codeine in the treatment of tension headache--the contribution of components to the combination drug. Clinical therapeutics, 1988, Volume: 10, Issue:3 Topics: Adolescent; Adult; Aspirin; Barbiturates; Caffeine; Codeine; Double-Blind Method; Drug Combinations;	1988
Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. Clinical therapeutics, 1987, Volume: 10, Issue:1 Topics: Acetaminophen; Adult; Barbiturates; Caffeine; Chronic Disease; Clinical Trials as Topic; Consumer Be	1987
Fiorinal with Codeine in the management of tension headache: impact of placebo response. Clinical therapeutics, 1987, Volume: 9, Issue:2 Topics: Adult; Anxiety; Aspirin; Barbiturates; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Met	1987
Human coffee drinking: reinforcing and physical dependence producing effects of caffeine. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:2 Topics: Adult; Caffeine; Coffee; Drinking; Emotions; Headache; Humans; Male; Middle Aged; Psychomotor Perfor	1986
Assessment of Fiorinal with Codeine in the treatment of tension headache. Clinical therapeutics, 1986, Volume: 8, Issue:6 Topics: Aspirin; Barbiturates; Caffeine; Codeine; Drug Combinations; Emotions; Headache; Humans; Muscle Cont	1986
[EMA 3--a phenacetin-free combination with analgesic action]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1973, Jun-12, Volume: 62, Issue:24 Topics: Acetaminophen; Adult; Aged; Allyl Compounds; Analgesics; Barbiturates; Caffeine; Clinical Trials as	1973
Double-blind clinical evaluation of the efficacy and safety of ergostine-caffeine, ergotamine-caffeine, and placebo in migraine headache. Headache, 1970, Volume: 9, Issue:4 Topics: Adolescent; Adult; Aged; Caffeine; Clinical Trials as Topic; Ergot Alkaloids; Ergotamine; Female; He	1970
Propoxyphene hydrochloride. A critical review. JAMA, 1970, Aug-10, Volume: 213, Issue:6 Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headac	1970
Controlled and uncontrolled studies on "Fiorinal-PA" for symptomatic relief in tension headache. The Medical journal of Australia, 1970, Jul-25, Volume: 2, Issue:4 Topics: Acetaminophen; Aspirin; Barbiturates; Caffeine; Clinical Trials as Topic; Drug Synergism; Headache;	1970

Article	Year
Attention-deficit/hyperactivity disorder, headache and caffeine. Psychological medicine, 2022, Volume: 52, Issue:1 Topics: Attention Deficit Disorder with Hyperactivity; Caffeine; Central Nervous System Stimulants; Headache	2022
Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study. Headache, 2022, Volume: 62, Issue:6 Topics: Acetaminophen; Caffeine; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Nonprescri	2022
Tracing the influence of caffeine on the pharmacokinetic parameters of three headache relieving pharmaceuticals applying synchronous fluorescence spectroscopy. Methods and applications in fluorescence, 2022, Aug-08, Volume: 10, Issue:4 Topics: Caffeine; Headache; Humans; Ibuprofen; Micelles; Spectrometry, Fluorescence	2022
2022 Taiwan Guidelines for Acute Treatment of Migraine. Acta neurologica Taiwanica, 2022, Jun-30, Volume: 31(2) Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Caffeine; Calcitonin G	2022
Student pharmacist characteristics and management of headache. Currents in pharmacy teaching & learning, 2022, Volume: 14, Issue:9 Topics: Adult; Caffeine; Drinking Water; Headache; Humans; Pharmacists; Students; United States	2022
Caffeine consumption as a risk factor for childhood and adolescence migraine. Pediatrics international : official journal of the Japan Pediatric Society, 2023, Volume: 65, Issue:1 Topics: Adolescent; Caffeine; Child; Chromatography, Liquid; Headache; Humans; Migraine Disorders; Risk Fact	2023
Caffeine consumption as a risk factor for childhood and adolescence migraine. Pediatrics international : official journal of the Japan Pediatric Society, 2023, Volume: 65, Issue:1 Topics: Adolescent; Caffeine; Child; Chromatography, Liquid; Headache; Humans; Migraine Disorders; Risk Fact	2023
Caffeine consumption as a risk factor for childhood and adolescence migraine. Pediatrics international : official journal of the Japan Pediatric Society, 2023, Volume: 65, Issue:1 Topics: Adolescent; Caffeine; Child; Chromatography, Liquid; Headache; Humans; Migraine Disorders; Risk Fact	2023
Caffeine consumption as a risk factor for childhood and adolescence migraine. Pediatrics international : official journal of the Japan Pediatric Society, 2023, Volume: 65, Issue:1 Topics: Adolescent; Caffeine; Child; Chromatography, Liquid; Headache; Humans; Migraine Disorders; Risk Fact	2023
Assessment of Headache Characteristics, Impact, and Managing Techniques among Pharmacy and Nursing Undergraduates-An Observational Study. Medicina (Kaunas, Lithuania), 2023, Jan-09, Volume: 59, Issue:1 Topics: Adult; Analgesics; Caffeine; Cross-Sectional Studies; Female; Headache; Humans; Male; Pharmacy; Qual	2023
Prevalence, characteristics, and factors associated with caffeine-withdrawal headache during the first day of Ramadan. Headache, 2023, Volume: 63, Issue:3 Topics: Body Weight; Caffeine; Cross-Sectional Studies; Headache; Humans; Prevalence; Substance Withdrawal S	2023
Association between dietary caffeine intake and severe headache or migraine in US adults. Scientific reports, 2023, 06-23, Volume: 13, Issue:1 Topics: Adult; Caffeine; Cross-Sectional Studies; Headache; Humans; Migraine Disorders; Nutrition Surveys; U	2023
Treatment of chronic cluster headache with burst and tonic occipital nerve stimulation: A case series. Headache, 2023, Volume: 63, Issue:8 Topics: Caffeine; Cluster Headache; Headache; Headache Disorders; Humans; Paresthesia; Research	2023
Prospective Cohort Study of Caffeinated Beverage Intake as a Potential Trigger of Headaches among Migraineurs. The American journal of medicine, 2019, Volume: 132, Issue:8 Topics: Adult; Beverages; Caffeine; Cohort Studies; Female; Headache; Humans; Logistic Models; Male; Middle	2019
Reversible cerebral vasoconstriction syndrome after sudden caffeine withdrawal. British journal of hospital medicine (London, England : 2005), 2019, Dec-02, Volume: 80, Issue:12 Topics: Caffeine; Central Nervous System Stimulants; Cerebral Angiography; Cerebral Hemorrhage; Computed Tom	2019
Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging. Molecules (Basel, Switzerland), 2021, Jan-25, Volume: 26, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Headache; Lasers; Nonprescription Drugs;	2021
New-onset headaches secondary to spontaneous intracranial hypotension. BMJ case reports, 2018, Jun-04, Volume: 2018 Topics: Anticoagulants; Anticonvulsants; Bed Rest; Blood Patch, Epidural; Brain Infarction; Caffeine; Centra	2018
Primary headache characters and coping strategies among medical students of Umm Al-Qura University in the Western Region of Saudi Arabia. Neurosciences (Riyadh, Saudi Arabia), 2018, Volume: 23, Issue:4 Topics: Adult; Analgesics; Caffeine; Female; Headache; Humans; Male; Migraine Disorders; Saudi Arabia; Sleep	2018
[Digital necrosis in hand by uncommon mechanism]. Dermatology online journal, 2013, Jul-14, Volume: 19, Issue:7 Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Analgesics, Non-Narcotic; Bisoprolol; Caffeine; Centr	2013
Use of aspirin combinations with caffeine and increasing headache frequency: a prospective population-based study. Pain, 2015, Volume: 156, Issue:9 Topics: Adolescent; Adult; Aged; Aspirin; Caffeine; Cohort Studies; Community Health Planning; Drug Combinat	2015
Energy drink consumption, health complaints and late bedtime among young adolescents. International journal of public health, 2016, Volume: 61, Issue:3 Topics: Adolescent; Adolescent Behavior; Caffeine; Dose-Response Relationship, Drug; Energy Drinks; Fatigue;	2016
Effect of exclusion of frequently consumed dietary triggers in a cohort of children with chronic primary headache. Nutrition and health, 2017, Volume: 23, Issue:1 Topics: Adolescent; Aspartame; Cacao; Caffeine; Cheese; Child; Child, Preschool; Chocolate; Citrus; Diet; Di	2017
Comparison of stadol NS and fiorinal with codeine. Headache, 1999, Volume: 39, Issue:2 Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Aspirin; Barbiturates; Butorph	1999
Posterior reversible encephalopathy syndrome after intravenous caffeine for post-lumbar puncture headaches. AJNR. American journal of neuroradiology, 2009, Volume: 30, Issue:3 Topics: Adult; Blood-Brain Barrier; Brain Edema; Caffeine; Central Nervous System Stimulants; Epilepsy, Toni	2009
High dietary caffeine consumption is associated with a modest increase in headache prevalence: results from the Head-HUNT Study. The journal of headache and pain, 2009, Volume: 10, Issue:3 Topics: Adult; Caffeine; Diet; Dose-Response Relationship, Drug; Drinking; Female; Headache; Health Surveys;	2009
Caffeine-withdrawal headache induced by hemodialysis. The journal of headache and pain, 2009, Volume: 10, Issue:4 Topics: Caffeine; Central Nervous System Stimulants; Cerebrovascular Circulation; Coffee; Disease Progressio	2009
Response to 'comments on results of Scher et al. pertaining to nonprescription caffeine-containing combination analgesics'. Cephalalgia : an international journal of headache, 2010, Volume: 30, Issue:12 Topics: Analgesics; Caffeine; Drug Combinations; Headache; Humans; Nonprescription Drugs	2010
Risk factors for high-altitude headache in mountaineers. Cephalalgia : an international journal of headache, 2011, Volume: 31, Issue:6 Topics: Adult; Alcohol Drinking; Altitude; Altitude Sickness; Caffeine; Central Nervous System Stimulants; E	2011
A hangover remedy for the holidays? Consumer reports, 2011, Volume: 76, Issue:1 Topics: Alcohol Drinking; Aspirin; Caffeine; Headache; Humans; Pain; Pain Management	2011
Patient education and self-advocacy: queries and responses on pain management. Journal of pain & palliative care pharmacotherapy, 2008, Volume: 22, Issue:4 Topics: Caffeine; Chronic Pain; Headache; Humans; Methadone; Pain Management; Sleep Apnea Syndromes	2008
Development of the caffeine withdrawal symptom questionnaire: caffeine withdrawal symptoms cluster into 7 factors. Drug and alcohol dependence, 2012, Aug-01, Volume: 124, Issue:3 Topics: Adolescent; Adult; Affect; Arousal; Caffeine; Cluster Analysis; Coffee; Fatigue; Female; Headache; H	2012
[Description of a series of cases of hypnic headache. Differentiation between sexes]. Revista de neurologia, 2012, Mar-16, Volume: 54, Issue:6 Topics: Age of Onset; Aged; Aged, 80 and over; Analgesics; Antidepressive Agents; Caffeine; Diagnosis, Diffe	2012
There is room for improvement in the prevention and treatment of headache after lumbar puncture. Danish medical journal, 2012, Volume: 59, Issue:7 Topics: Analgesics; Bed Rest; Caffeine; Central Nervous System Stimulants; Denmark; Fluid Therapy; Headache;	2012
Potential health problems with the use of energy drinks. The West Indian medical journal, 2012, Volume: 61, Issue:1 Topics: Adolescent; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Drug In	2012
Caffeine withdrawal: a model for migraine? Headache, 2002, Volume: 42, Issue:6 Topics: Caffeine; Headache; Humans; Models, Biological; Substance Withdrawal Syndrome	2002
[Chronic daily headaches caused by too much caffeine]. Nederlands tijdschrift voor geneeskunde, 2002, Oct-05, Volume: 146, Issue:40 Topics: Adult; Aged; Caffeine; Chronic Disease; Female; Headache; Humans; Male; Substance-Related Disorders	2002
Drug-induced hepatitis with hepatic granuloma due to saridon. Journal of gastroenterology, 2002, Volume: 37, Issue:12 Topics: Adult; Antipyrine; Biopsy, Needle; Caffeine; Chemical and Drug Induced Liver Injury; Dose-Response R	2002
Caffeine-induced headache in children and adolescents. Cephalalgia : an international journal of headache, 2003, Volume: 23, Issue:5 Topics: Adolescent; Caffeine; Carbonated Beverages; Child; Diet Records; Female; Follow-Up Studies; Headache	2003
Perioperative headache and day case surgery. European journal of anaesthesiology, 2003, Volume: 20, Issue:5 Topics: Adult; Alcohol Drinking; Ambulatory Surgical Procedures; Caffeine; Female; Headache; Humans; Logisti	2003
Caffeine consumption in drivers of heavy vehicles in Turkey. Public health, 2003, Volume: 117, Issue:5 Topics: Accidents, Traffic; Acetaminophen; Adult; Caffeine; Cross-Sectional Studies; Headache; Humans; Middl	2003
The effect of theophylline with ethylenediamine (aminophylline) and caffeine on cerebral hemodynamics and cerebrospinal fluid pressure in patients with hypertensive headaches. The American journal of the medical sciences, 1952, Volume: 224, Issue:4 Topics: Aminophylline; Caffeine; Cerebrospinal Fluid Pressure; Ethylenediamines; Headache; Hemodynamics; Hum	1952
[Trial treatment of headaches of pneumo-encephalography by combination of ergotamine tartrate and caffeine]. Gazette medicale de France, 1952, Volume: 59, Issue:9 Topics: Caffeine; Ergotamine; Headache; Humans; Pneumoencephalography	1952
Fiorinal for symptomatic treatment of nonvascular headache. Missouri medicine, 1953, Volume: 50, Issue:4 Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Headache; Humans	1953
[Combined ergotamine and caffeine in therapy of vascular headaches]. Revue medicale de la Suisse romande, 1953, Volume: 73, Issue:8 Topics: Caffeine; Cardiovascular Agents; Ergot Alkaloids; Ergotamine; Headache; Humans; Oxytocics; Vascular	1953
The treatment of headache with cafergot suppositories. Wisconsin medical journal, 1954, Volume: 53, Issue:3 Topics: Caffeine; Cardiovascular Agents; Drug Combinations; Ergot Alkaloids; Ergotamine; Headache; Oxytocics	1954
Saddle block anesthesia in obstetrics; treatment of postpartum spinal headache. Obstetrics and gynecology, 1955, Volume: 5, Issue:1 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, Spinal; Caffeine; Ergot Alkaloids; Fema	1955
[Treatment of headache with cafergot]. Wiener klinische Wochenschrift, 1955, Jun-24, Volume: 67, Issue:25 Topics: Caffeine; Cardiovascular Agents; Drug Combinations; Ergot Alkaloids; Ergotamine; Headache; Migraine	1955
[Pathogenesis and therapy of vascular cephalalgia]. Wiener medizinische Wochenschrift (1946), 1956, Jan-14, Volume: 106, Issue:2 Topics: Caffeine; Cardiovascular Agents; Ergot Alkaloids; Headache; Migraine Disorders	1956
[Findings on the effects of the administration of caffeine with ergotamine tartrate (cafergot) on relievable retinal and intracranial circulatory modifications in histamine headache]. Bollettino d'oculistica, 1955, Volume: 34, Issue:12 Topics: Brain; Caffeine; Cluster Headache; Drug Combinations; Ergot Alkaloids; Ergotamine; Headache; Histami	1955
A recent preparation for the relief of vascular headache; preliminary report. Quarterly review of allergy and applied immunology, 1956, Volume: 10, Issue:1 Topics: Alkaloids; Atropa belladonna; Caffeine; Cardiovascular Agents; Ergot Alkaloids; Gastrointestinal Age	1956
[Favorable effect of ergotamine tartrate with caffeine on headache subsequent to gaseous electroencephalography]. Cahiers de psychiatrie, 1956, Issue:11 Topics: Brain; Caffeine; Cardiovascular Agents; Electroencephalography; Ergot Alkaloids; Ergotamine; Headach	1956
A new agent for the control of headache. The Medical annals of the District of Columbia, 1957, Volume: 26, Issue:4 Topics: Belladonna Alkaloids; Caffeine; Cardiovascular Agents; Ergot Alkaloids; Headache; Humans; Oxytocics;	1957
[The so-called "Sekundenphänomen" in headaches caused by spinal anesthesia]. Minerva anestesiologica, 1957, Volume: 23, Issue:1 Topics: Anesthesia; Anesthesia, Spinal; Anesthesiology; Caffeine; Headache; Humans; Procaine	1957
[Cafergot compound (suppositories) in therapy of migraine & Horton's syndrome]. Svenska lakartidningen, 1957, May-17, Volume: 54, Issue:20 Topics: Caffeine; Cardiovascular Agents; Cluster Headache; Drug Combinations; Ergot Alkaloids; Ergotamine; H	1957
[Symptomatic treatment of headache with coffo-salt]. Wiener medizinische Wochenschrift (1946), 1957, Apr-06, Volume: 107, Issue:14 Topics: Analgesics; Caffeine; Headache; Humans	1957
[Treatment of headache after lumbar puncture & pneumoencephalography with ergotamine in combination with caffeine (cafergot)]. Praxis, 1958, Jul-03, Volume: 47, Issue:27 Topics: Caffeine; Cerebral Ventriculography; Drug Combinations; Ergot Alkaloids; Ergotamine; Headache; Human	1958
[Ergotamine & caffeine (cafergot) treatment of headaches after lumbar puncture & pneumoencephalography]. Polski tygodnik lekarski, 1958, Oct-06, Volume: 13, Issue:40 Topics: Amides; Anesthesia; Anesthesia, Spinal; Anesthesiology; Caffeine; Cerebral Ventriculography; Drug Co	1958
Effectiveness of a new analgesic-calmative preparation and acetylsalicylic acid in the treatment of headache and other pain. Mississippi Valley medical journal (Quincy, Ill), 1959, Volume: 81, Issue:4 Topics: Analgesics; Anti-Allergic Agents; Aspirin; Caffeine; Headache; Histamine H1 Antagonists; Humans; Pai	1959
Headache. Pharmacological approach to treatment. California medicine, 1961, Volume: 95 Topics: Caffeine; Headache; Headache Disorders; Humans; Hypnotics and Sedatives; Migraine Disorders; Tension	1961
[Continuous treatment of headache with coffanolamine in patients with migraine]. Ugeskrift for laeger, 1961, Mar-31, Volume: 123 Topics: Caffeine; Ergot Alkaloids; Headache; Migraine Disorders; Oxytocics	1961
Headache clinics No. VIII. Vascular headache: ergotamine tartrate, caffeine and antiemetic combnation as an adjunct in therapy. American practitioner and digest of treatment, 1960, Volume: 11 Topics: Anti-Allergic Agents; Antiemetics; Caffeine; Cardiovascular Agents; Ergot Alkaloids; Ergotamine; Hea	1960
Morning headache. Medical times, 1960, Volume: 88 Topics: Biomedical Research; Caffeine; Cardiovascular Agents; Ergot Alkaloids; Headache; Oxytocics	1960
[On a new kind of analgesia with a new caffeine derivative]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1959, Jul-15, Volume: 14 Topics: Analgesia; Caffeine; Headache; Pain; Pain Management; Rheumatic Diseases	1959
Caffeine, chocolate and withdrawal headaches. Northwest medicine, 1960, Volume: 59 Topics: Behavior, Addictive; Cacao; Caffeine; Headache; Humans; Substance-Related Disorders	1960
[On the therapy of idiopathic and symptomatic headache and facial pains]. Medizinische Monatsschrift, 1963, Volume: 17 Topics: Caffeine; Facial Neuralgia; Facial Pain; Headache; Humans; Phenytoin; Trigeminal Neuralgia	1963
[TREATMENT OF DYSRHYTHMIC MIGRAINE AND OTHER FORMS OF HEADACHE WITH A NEW COMBINATION PREPARATION (SANREDO)]. Schweizerische medizinische Wochenschrift, 1963, Sep-14, Volume: 93 Topics: Caffeine; Ergotamine; Headache; Humans; Migraine Disorders; Phenytoin	1963
MODERN CONCEPTS OF THE MANAGEMENT OF HISTAMINIC CEPHALALGIA. Southern medical journal, 1963, Volume: 56 Topics: Atropa belladonna; Caffeine; Ergotamine; Headache; Histamine; Humans; Methysergide; Muscarinic Antag	1963
[INCIDENTS IN REID'S INTRACISTERNAL THERAPY WITH PROCAINE-CAFFEINE MIXTURES]. Die Medizinische Welt, 1963, Nov-23, Volume: 47 Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Caffeine; Encephalomyelitis; Epilepsy; Headache;	1963
THE DIAGNOSIS AND TREATMENT OF HISTAMINIC CEPHALALGIA. The West Virginia medical journal, 1964, Volume: 60 Topics: Atropa belladonna; Caffeine; Ergotamine; Headache; Histamine; Humans; Pentobarbital	1964
NASAL VASCULAR HEADACHE. The Laryngoscope, 1964, Volume: 74 Topics: Aerosols; Caffeine; Diagnosis; Ergotamine; Headache; Humans; Migraine Disorders; Neuralgia; Nose; Va	1964
TIME PATTERNS IN HEADACHE; THEIR DIAGNOSTIC AND THERAPEUTIC SIGNIFICANCE. The Journal of the Maine Medical Association, 1964, Volume: 55 Topics: Amphetamine; Amphetamines; Caffeine; Diagnosis; Ergot Alkaloids; Ergotamine; Headache; Menstruation;	1964
[MEDICAL HEADACHES]. Aggiornamenti clinicoterapeutici, 1964, Volume: 5 Topics: Aminophylline; Amphetamine; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Barbiturates; Caffei	1964
DRUGS FOR HEADACHE OF MIGRAINOUS, VASCULAR OR MUSCULAR ORIGIN. Canadian Medical Association journal, 1964, Jul-25, Volume: 91 Topics: Aspirin; Caffeine; Cardiovascular Agents; Ergot Alkaloids; Ergotamine; Headache; Humans; Meprobamate	1964
THE EFFECTS OF THERAPY WITH A NONDEPRESSANT ANALGESIC COMBINATION. Current therapeutic research, clinical and experimental, 1964, Volume: 6 Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Arthritis; Aspirin; Biomedical Research; Caffein	1964
TREATMENT OF NONMIGRAINOUS VASCULAR HEADACHE. Modern treatment, 1964, Volume: 1 Topics: Alcoholic Intoxication; Caffeine; Headache; Humans; Hypersensitivity; Hypertension; Iatrogenic Disea	1964
PHENACETIN NEPHROPATHY. Canadian Medical Association journal, 1965, Jan-09, Volume: 92 Topics: Acidosis; Animals; Aspirin; Bacteriuria; Biological Transport; Caffeine; Codeine; Dogs; Drug Therapy	1965
WAKEFULNESS CAUSED BY CAFFEINE. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1964, May-25, Volume: 248 Topics: Biomedical Research; Caffeine; Headache; Humans; Lactose; Pharmacology; Sleep; Sleep Wake Disorders;	1964
ANALGESIC COMBINATION IN HEADACHE. Headache, 1965, Volume: 5 Topics: Analgesics; Arthritis; Aspirin; Back Pain; Caffeine; Cervical Vertebrae; Drug Therapy; Headache; Hum	1965
NEPHROPATHY ASSOCIATED WITH THE USE OF ANALGESIC MEDICATIONS. Annals of internal medicine, 1965, Volume: 62 Topics: Acute Kidney Injury; Amobarbital; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antip	1965
TENSION HEADACHE: A NEW AGENT FOR ITS SYMPTOMATIC RELIEF. Headache, 1965, Volume: 5 Topics: Aspirin; Barbiturates; Caffeine; Diagnosis; Drug Therapy; Headache; Humans; Mental Disorders; Phenac	1965
Symptomatic treatment of headache. American practitioner and digest of treatment, 1950, Volume: 1, Issue:12 Topics: Caffeine; Ergonovine; Ergot Alkaloids; Headache	1950
Treatment of headache; Four new agents compared with Cafergot and E.C.B.-210. Missouri medicine, 1951, Volume: 48, Issue:2 Topics: Caffeine; Drug Combinations; Ergot Alkaloids; Ergotamine; Headache; Humans	1951
A clinical report on the relief of headaches non-responsive to analgesics. The Journal of the Kansas Medical Society, 1951, Volume: 52, Issue:8 Topics: Analgesics; Caffeine; Ergonovine; Ergot Alkaloids; Headache	1951
Caffeine-withdrawal headache. The Vågå study of headache epidemiology. Cephalalgia : an international journal of headache, 2004, Volume: 24, Issue:4 Topics: Adolescent; Adult; Aged; Caffeine; Central Nervous System Stimulants; Coffee; Denmark; Female; Heada	2004
Headache, stomachache, backache, and morning fatigue among adolescent girls in the United States: associations with behavioral, sociodemographic, and environmental factors. Archives of pediatrics & adolescent medicine, 2004, Volume: 158, Issue:8 Topics: Abdominal Pain; Adolescent; Adolescent Behavior; Alcohol Drinking; Back Pain; Caffeine; Comorbidity;	2004
Acute onset of bilateral myoclonus in a 16-year-old female. Journal of the Mississippi State Medical Association, 2004, Volume: 45, Issue:6 Topics: Acetaminophen; Acute Disease; Adolescent; Aspirin; Attention Deficit Disorder with Hyperactivity; Ca	2004
Observations on the symptomatic treatment of chronic vascular headache with cafergone (ergotamine tartrate and caffeine). The New England journal of medicine, 1949, Dec-08, Volume: 241, Issue:23 Topics: Caffeine; Ergot Alkaloids; Ergotamine; Headache; Humans; Vascular Headaches	1949
Treatment of headache with cafergone. Arizona medicine, 1949, Volume: 6, Issue:12 Topics: Caffeine; Drug Combinations; Ergotamine; Headache; Humans	1949
Cafergone for relief of headache. Missouri medicine, 1950, Volume: 47, Issue:2 Topics: Caffeine; Ergot Alkaloids; Headache	1950
Self-medication among Finnish young men in the beginning of common military service. Pharmacoepidemiology and drug safety, 2005, Volume: 14, Issue:3 Topics: Adult; Anxiety; Caffeine; Central Nervous System Stimulants; Common Cold; Cross-Sectional Studies; E	2005
Information from your family doctor. Rebound headaches. American family physician, 2004, Dec-15, Volume: 70, Issue:12 Topics: Analgesics; Caffeine; Complementary Therapies; Headache; Humans; Life Style; Self Care	2004
[Three Japanese cases of hypnic headache]. Rinsho shinkeigaku = Clinical neurology, 2006, Volume: 46, Issue:2 Topics: Aged; Caffeine; Circadian Rhythm; Female; Headache; Humans; Hypothalamic Diseases; Hypothalamo-Hypop	2006
Acetylsalicylic acid, paracetamol and caffeine combination in headache. Cephalalgia : an international journal of headache, 2006, Volume: 26, Issue:10 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine;	2006
[Chronic interstitial nephritis in an 18-year-old due to intake of a compound analgesic]. Medizinische Klinik (Munich, Germany : 1983), 2006, Oct-15, Volume: 101, Issue:10 Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Caffeine; Creat	2006
The fixed combination of acetylsalicylic acid, paracetamol and caffeine. Cephalalgia : an international journal of headache, 2006, Volume: 26, Issue:12 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine;	2006
Headache as seen by the otolaryngologist with special reference to the use of cafergone-E.C. 110 ergotamine tartrate and caffeine for the relief of attacks. Christ Hospital medical bulletin, 1949, Volume: 2, Issue:4 Topics: Caffeine; Claviceps; Ergonovine; Ergot Alkaloids; Ergotamine; Headache; Social Behavior	1949
Fiorinal and other sedative-analgesic drugs for "tension" headache. The Medical letter on drugs and therapeutics, 1967, May-19, Volume: 9, Issue:10 Topics: Aspirin; Barbiturates; Caffeine; Codeine; Headache; Humans; Phenacetin	1967
The patient with headache. Postgraduate medicine, 1967, Volume: 42, Issue:4 Topics: Age Factors; Alkaloids; Atropa belladonna; Caffeine; Diagnosis, Differential; Ergotamine; Headache;	1967
Headache--diagnosis and effective management. The Western journal of medicine, 1984, Volume: 140, Issue:6 Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Cluster Headache; Drug Combinations; Ergotamine; Headac	1984
An alternative treatment for spinal headache. The Journal of family practice, 1982, Volume: 15, Issue:1 Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Benzoates; Caffeine; Drug Combinations; Female;	1982
Headache. The New England journal of medicine, 1980, Jul-24, Volume: 303, Issue:4 Topics: Caffeine; Headache; Humans; Substance Withdrawal Syndrome	1980
Caffeine-withdrawal headache: a clinical profile. Psychosomatics, 1980, Volume: 21, Issue:5 Topics: Adult; Anxiety; Caffeine; Depression; Female; Headache; Humans; Substance Withdrawal Syndrome	1980
[Caffeine gives relief after lumbar puncture]. Lakartidningen, 1993, Mar-10, Volume: 90, Issue:10 Topics: Caffeine; Headache; Humans; Infusions, Intravenous; Spinal Puncture	1993
Identification of problem foods using food and symptom diaries. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1995, Volume: 112, Issue:3 Topics: Abdominal Pain; Adult; Caffeine; Child; Diet Records; Eating; Ethanol; Fatigue; Feeding Behavior; Fe	1995
Effect of previous frequency of headache, duration of fasting and caffeine abstinence on perioperative headache. British journal of anaesthesia, 1994, Volume: 72, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics; Beverages; C	1994
Postdural puncture headache. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1994, Mar-15, Volume: 150, Issue:6 Topics: Caffeine; Headache; Humans; Spinal Puncture	1994
Postoperative transient hemihypaesthesia and severe headache associated with caffeine withdrawal. Anaesthesia, 1994, Volume: 49, Issue:3 Topics: Adult; Caffeine; Coffee; Female; Headache; Humans; Hypesthesia; Postoperative Complications; Substan	1994
Chronic daily headache--one disease or two? Diagnostic role of serum ionized magnesium. Cephalalgia : an international journal of headache, 1994, Volume: 14, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Caffeine; Chronic Disease; Diagnosis, Differential; Fema	1994
Headaches? Change your diet. RN, 1993, Volume: 56, Issue:5 Topics: Aspartame; Caffeine; Diet; Food Additives; Food Hypersensitivity; Headache; Humans; Tyramine	1993
Perioperative ingestion of caffeine and postoperative headache. Mayo Clinic proceedings, 1993, Volume: 68, Issue:9 Topics: Adult; Aged; Caffeine; Coffee; Female; Headache; Humans; Male; Middle Aged; Postoperative Period; Pr	1993
For want of a cup of coffee. Mayo Clinic proceedings, 1993, Volume: 68, Issue:9 Topics: Caffeine; Headache; Humans; Postoperative Period; Preoperative Care; Substance Withdrawal Syndrome	1993
Caffeine dependence: an alternative view. Nature medicine, 1996, Volume: 2, Issue:5 Topics: Affect; Caffeine; Headache; Humans; Models, Psychological; Substance Withdrawal Syndrome; Substance-	1996
[Episodic headache, diminished performance and depressive mood]. Praxis, 1996, May-28, Volume: 85, Issue:22 Topics: Adult; Caffeine; Depression; Fatigue; Headache; Humans; Male; Substance Withdrawal Syndrome	1996
Influence of caffeine and caffeine withdrawal on headache and cerebral blood flow velocities. Cephalalgia : an international journal of headache, 1997, Volume: 17, Issue:3 Topics: Adult; Caffeine; Cerebrovascular Circulation; Female; Headache; Humans; Male; Middle Aged; Substance	1997
[Clinical features of daily chronic headache]. Revista de neurologia, 1997, Volume: 25, Issue:143 Topics: Acetaminophen; Adult; Age of Onset; Analgesics; Benzodiazepines; Caffeine; Chronic Disease; Ergotami	1997
Drug- and caffeine-induced headaches. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1997, Sep-01, Volume: 157, Issue:5 Topics: Caffeine; Drug-Related Side Effects and Adverse Reactions; Headache; Humans; Migraine Disorders	1997
Alcohol, smoking, and caffeine use among headache patients. Headache, 1997, Volume: 37, Issue:9 Topics: Adolescent; Adult; Aged; Alcohol Drinking; Analgesics; Beverages; Caffeine; Female; Headache; Humans	1997
The hypnic ("alarm clock") headache syndrome. Cephalalgia : an international journal of headache, 1998, Volume: 18, Issue:3 Topics: Adult; Aged; Caffeine; Circadian Rhythm; Female; Headache; Humans; Lithium Carbonate; Male; Middle A	1998
Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:9 Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, No	1998
Treatment for postdural puncture headache associated with late postpartum eclampsia. Acta anaesthesiologica Belgica, 1999, Volume: 50, Issue:2 Topics: Acetaminophen; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Benzoat	1999
[Intractable vomiting, convulsions and megaloblastic anemia: anamnesis, key to diagnosis]. Schweizerische medizinische Wochenschrift, 1999, Jul-03, Volume: 129, Issue:26 Topics: Adult; Anemia, Megaloblastic; Barbiturates; Caffeine; Diagnosis, Differential; Drug Combinations; Er	1999
[Headache and chronic sleep deprivation: an often missed relationship in children and also in adults]. Nederlands tijdschrift voor geneeskunde, 1999, Dec-11, Volume: 143, Issue:50 Topics: Adult; Caffeine; Central Nervous System Stimulants; Child; Fatigue; Female; Headache; Humans; Male;	1999
[Headache following dural puncture refractory to caffeine]. Revista espanola de anestesiologia y reanimacion, 2000, Volume: 47, Issue:5 Topics: Adult; Anesthesia, Spinal; Arthroscopy; Caffeine; Drug Resistance; Dura Mater; Female; Headache; Hum	2000
Use of caffeine in post-dural puncture headache: a case report. Delaware medical journal, 2001, Volume: 73, Issue:3 Topics: Adult; Caffeine; Central Nervous System Stimulants; Female; Headache; Humans; Spinal Puncture	2001
Myth: fluids, bed rest, and caffeine are effective in preventing and treating patients with post-lumbar puncture headache. The Western journal of medicine, 2002, Volume: 176, Issue:1 Topics: Bed Rest; Caffeine; Central Nervous System Stimulants; Fluid Therapy; Headache; Humans	2002
Clinical features of withdrawal headache following overuse of triptans and other headache drugs. Neurology, 2002, May-14, Volume: 58, Issue:9 Topics: Analgesics; Caffeine; Causality; Codeine; Drug Overdose; Headache; Headache Disorders; Humans; Prosp	2002
[Treatment of post-dural-puncture headache with intravenous cortisone]. Revista espanola de anestesiologia y reanimacion, 2002, Volume: 49, Issue:2 Topics: Acetaminophen; Adult; Analgesics; Anesthesia, Epidural; Anesthesia, Obstetrical; Anti-Inflammatory A	2002
[Drug therapy of migraine and cluster headache]. Deutsche medizinische Wochenschrift (1946), 1975, Jun-06, Volume: 100, Issue:23 Topics: Analgesics; Barbiturates; Caffeine; Dihydroergotamine; Drug Synergism; Ergot Alkaloids; Headache; Hi	1975
Caffeine-withdrawal headache and fasting. New York state journal of medicine, 1977, Volume: 77, Issue:2 Topics: Adolescent; Adult; Caffeine; Child; Coffee; Diet; Fasting; Female; Headache; Humans; Jews; Male; Sub	1977
Phenelzine-cola headache. American journal of hospital pharmacy, 1979, Volume: 36, Issue:6 Topics: Adult; Beverages; Caffeine; Carbonated Beverages; Drug Interactions; Female; Headache; Humans; Hyper	1979
Headaches and coffee. British medical journal, 1977, Jul-30, Volume: 2, Issue:6082 Topics: Caffeine; Coffee; Headache; Humans	1977
Editorial: Anxiety symptoms and coffee drinking. British medical journal, 1975, Feb-08, Volume: 1, Issue:5953 Topics: Anxiety Disorders; Caffeine; Coffee; Headache; Humans	1975
[Cluster headache]. Nederlands tijdschrift voor geneeskunde, 1975, Mar-01, Volume: 119, Issue:9 Topics: Adult; Caffeine; Ergot Alkaloids; Ergotamines; Female; Ganglia, Autonomic; Headache; Humans; Male; M	1975
[Therapy of chronic headache in daily practice]. Zeitschrift fur arztliche Fortbildung, 1975, Sep-15, Volume: 69, Issue:18 Topics: Caffeine; Chronic Disease; Female; Headache; Humans; Male; Procaine	1975
Comments on Ward et al., PAIN, 44 (1991) 151-155. Pain, 1992, Volume: 51, Issue:1 Topics: Analgesics; Caffeine; Headache; Humans	1992
Reply to the letter of Harlan and Davey, PAIN, 47 (1991) 245. Pain, 1992, Volume: 49, Issue:1 Topics: Caffeine; Headache; Humans; Pain Measurement; Placebos	1992
Comments on 'The analgesic effects of caffeine in headache,' by D. Avery, D. Dunner, N. Ward and C. Whitney in Pain, 44 (1991) 151-155. Pain, 1991, Volume: 47, Issue:2 Topics: Caffeine; Headache; Humans; Research Design	1991
Effects of caffeine on tobacco withdrawal. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:2 Topics: Adult; Caffeine; Dose-Response Relationship, Drug; Female; Headache; Humans; Hunger; Male; Patient C	1991
Does caffeine contribute to postoperative morbidity? Lancet (London, England), 1990, Sep-08, Volume: 336, Issue:8715 Topics: Adult; Caffeine; Female; Headache; Humans; Male; Postoperative Complications	1990
Is caffeine withdrawal the mechanism of postoperative headache? Anesthesia and analgesia, 1991, Volume: 72, Issue:4 Topics: Adult; Aged; Anesthesia, General; Caffeine; Female; Headache; Humans; Male; Middle Aged; Postoperati	1991
Drug abuse and headache. The Medical clinics of North America, 1991, Volume: 75, Issue:3 Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Ergot Alkaloi	1991
[A case of chronic renal failure caused by 20-year intake of pyrcophen]. Klinicheskaia meditsina, 1990, Volume: 68, Issue:8 Topics: Aminopyrine; Analgesics; Caffeine; Drug Combinations; Female; Headache; Humans; Kidney Failure, Chro	1990
A protocol for butalbital, aspirin and caffeine (BAC) detoxification in headache patients. Headache, 1990, Volume: 30, Issue:8 Topics: Adult; Aspirin; Barbiturates; Caffeine; Clinical Protocols; Combined Modality Therapy; Female; Heada	1990
Headache caused by caffeine withdrawal among moderate coffee drinkers switched from ordinary to decaffeinated coffee: a 12 week double blind trial. BMJ (Clinical research ed.), 1990, Jun-16, Volume: 300, Issue:6739 Topics: Adult; Caffeine; Coffee; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged; Substance	1990
Does caffeine withdrawal contribute to postanaesthetic morbidity? Lancet (London, England), 1989, Jun-10, Volume: 1, Issue:8650 Topics: Adolescent; Adult; Aged; Anesthesia, General; Caffeine; Female; Headache; Humans; Male; Middle Aged;	1989
Caffeine abstinence effects in humans. NIDA research monograph, 1989, Volume: 95 Topics: Arousal; Caffeine; Fatigue; Headache; Humans; Substance Withdrawal Syndrome	1989
Longterm prognosis of analgesic withdrawal in patients with drug-induced headaches. Headache, 1989, Volume: 29, Issue:8 Topics: Adult; Caffeine; Ergotamine; Female; Headache; Humans; Male; Middle Aged; Prognosis; Pyrazoles; Pyra	1989
Postpartum seizure after epidural blood patch and intravenous caffeine sodium benzoate. Anesthesiology, 1989, Volume: 70, Issue:1 Topics: Adult; Analgesia, Epidural; Anesthesia, Obstetrical; Benzoates; Blood; Caffeine; Drug Combinations;	1989
Caffeine withdrawal headache. Journal of clinical pharmacy and therapeutics, 1987, Volume: 12, Issue:1 Topics: Adult; Caffeine; Diet; Headache; Humans; Male; Pharmaceutical Preparations; Substance Withdrawal Syn	1987
Should caffeine become the first-line treatment for postdural puncture headache? Anesthesia and analgesia, 1987, Volume: 66, Issue:9 Topics: Anesthesia, Epidural; Benzoates; Caffeine; Drug Combinations; Dura Mater; Headache; Humans; Posture	1987
Orthostatic hypotension caused by headache therapy. Postgraduate medicine, 1987, Volume: 82, Issue:5 Topics: Caffeine; Coffee; Fludrocortisone; Headache; Humans; Hypotension, Orthostatic	1987
Headache related to chronic caffeine addiction. Texas dental journal, 1985, Volume: 102, Issue:7 Topics: Caffeine; Female; Headache; Humans; Middle Aged; Substance-Related Disorders	1985
A study of caffeine consumption and symptoms; indigestion, palpitations, tremor, headache and insomnia. International journal of epidemiology, 1985, Volume: 14, Issue:2 Topics: Adult; Aged; Alcohol Drinking; Australia; Caffeine; Coffee; Cross-Sectional Studies; Digestion; Dose	1985
Intravenous caffeine for postdural puncture headache. Anesthesia and analgesia, 1986, Volume: 65, Issue:3 Topics: Anesthesia, Spinal; Caffeine; Headache; Humans; Injections, Intravenous	1986
[Treatment of migraine and other vasomotoric headaches using Migrexa]. Munchener medizinische Wochenschrift (1950), 1969, Jan-31, Volume: 111, Issue:5 Topics: Analgesics; Caffeine; Diagnosis, Differential; Ergotamine; Headache; Histamine Release; Humans; Migr	1969
[Clinical study of a new antalgic: Propofan]. Lyon medical, 1972, Jan-23, Volume: 227, Issue:2 Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Caffeine; Dextropropoxyphene; Female; Headache; His	1972
[Octadon N]. Therapie der Gegenwart, 1974, Volume: 113, Issue:7 Topics: Analgesics; Aspirin; Caffeine; Drug Combinations; Germany, West; Headache; Humans; Migraine Disorder	1974
Bilateral papillitis associated with Cafergot therapy. Neurology, 1972, Volume: 22, Issue:8 Topics: Adult; Caffeine; Ergotamine; Female; Headache; Humans; Optic Neuritis; Papillary Muscles; Papilledem	1972
[Caffeine, coffee, headache and migraine]. Medizinische Klinik, 1973, May-11, Volume: 68, Issue:19 Topics: Adrenal Glands; Animals; Caffeine; Female; Glucose; Headache; Hemodynamics; Humans; Hypertension; Ma	1973
"Fiorinal" in the treatment of tension headache and other painful states associated with nervous tension. The Medical journal of Australia, 1968, Feb-17, Volume: 1, Issue:7 Topics: Adolescent; Adult; Analgesics; Aspirin; Barbiturates; Caffeine; Dysmenorrhea; Female; Headache; Huma	1968
Analgesic habits of 500 veterans: incidence and complications of abuse. Canadian Medical Association journal, 1968, Mar-30, Volume: 98, Issue:13 Topics: Adult; Aged; Analgesics; Anemia; Arthritis; Aspirin; Caffeine; Canada; Codeine; Gastrointestinal Hem	1968
[Tension headache. Treatment using FIO]. Hospital (Rio de Janeiro, Brazil), 1968, Volume: 74, Issue:2 Topics: Adult; Aged; Aspirin; Barbiturates; Caffeine; Drug Synergism; Female; Headache; Humans; Male; Middle	1968
[Treatment of vascular headache]. Medizinische Monatsschrift, 1969, Volume: 23, Issue:9 Topics: Adult; Amobarbital; Caffeine; Codeine; Ergotamine; Female; Headache; Humans; Male; Middle Aged; Phen	1969
Caffeine and headache. JAMA, 1970, Jul-27, Volume: 213, Issue:4 Topics: Caffeine; Female; Headache; Humans	1970
Sphenopalatine gangionectomy for cluster headache. Archives of otolaryngology (Chicago, Ill. : 1960), 1970, Volume: 92, Issue:5 Topics: Adult; Analgesics; Caffeine; Carbamazepine; Cortisone; Diazepam; Ergotamine; Female; Ganglia, Autono	1970
[Therapy of the vasomotor headache in childhood]. Medizinische Monatsschrift, 1970, Volume: 24, Issue:9 Topics: Adolescent; Amines; Amobarbital; Caffeine; Child; Child, Preschool; Codeine; Ergotamine; Headache; H	1970
[Experiences with Ergo-Lonarid in the treatment of headaches in otorhinolaryngological practice]. Deutsches medizinisches Journal, 1970, Volume: 21, Issue:2 Topics: Amobarbital; Caffeine; Codeine; Ergotamine; Headache; Humans; Otorhinolaryngologic Diseases; Phenols	1970
[Treatment of vascular headaches with a new compound preparation]. Zeitschrift fur Allgemeinmedizin, 1970, Feb-28, Volume: 46, Issue:6 Topics: Acetaminophen; Adult; Amobarbital; Analgesics; Caffeine; Codeine; Ergotamine; Female; Headache; Huma	1970
[Treatment of headache with Ergo-Lonarid]. Therapie der Gegenwart, 1971, Volume: 110, Issue:3 Topics: Amobarbital; Analgesics; Caffeine; Codeine; Diagnosis, Differential; Ergotamine; Headache; Humans	1971
[Prophylaxis and therapy of the mountain sickness, puna]. Schweizerische medizinische Wochenschrift, 1971, May-08, Volume: 101, Issue:18 Topics: Altitude; Caffeine; Ergotamine; Headache; Humans; Hypoxia; Nausea; Oxygen Inhalation Therapy; Physic	1971
Syndrome associated with the abuse of analgesics. Annals of internal medicine, 1968, Volume: 68, Issue:4 Topics: Adult; Age Factors; Analgesics; Anemia; Animals; Aspirin; Caffeine; Cats; Dogs; Female; Guinea Pigs;	1968
[Study of a test of active headache extinction]. Rivista critica di clinica medica, 1968, Volume: 68, Issue:4 Topics: Caffeine; Diagnosis, Differential; Headache; Humans; Indomethacin; Migraine Disorders; Prochlorperaz	1968
[Changes in hemodynamics observed during the extinction phase of headache attacks]. Rivista critica di clinica medica, 1968, Volume: 68 Topics: Blood Pressure; Brachial Artery; Caffeine; Headache; Hemodynamics; Humans; Indomethacin; Migraine Di	1968
Coffee. Canadian Medical Association journal, 1969, Apr-12, Volume: 100, Issue:14 Topics: Animals; Caffeine; Coffee; Headache; Humans	1969

caffeine and Bilateral Headache