caffeine has been researched along with Benign Neoplasms in 117 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Caffeine infusion significantly reduced pain and drowsiness, but the reduction did not reach clinical significance in patients with advanced cancer undergoing opioid therapy." | 9.17 | Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial. ( Ahn, HY; Bae, WK; Cho, K; Choi, YS; Kim, YS; Lee, JH; Oh, SC; Seo, AR; Suh, SY, 2013) |
| " We propose that tumor protection is to a large extent due to (a) inhibition of antitumor T cells by hypoxia-driven accumulation of extracellular adenosine in local tumor microenvironment and due to (b) T regulatory cell-produced extracellular adenosine." | 8.84 | Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia. ( Kjaergaard, J; Lukashev, D; Ohta, A; Sitkovsky, MV, 2008) |
| "Acetaldehyde formation was determined by GC-FID analysis in the head space of incubation mixtures." | 5.31 | Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects. ( Castro, GD; Castro, JA; Costantini, MH; Delgado de Layño, AM, 2001) |
| "Caffeine infusion significantly reduced pain and drowsiness, but the reduction did not reach clinical significance in patients with advanced cancer undergoing opioid therapy." | 5.17 | Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial. ( Ahn, HY; Bae, WK; Cho, K; Choi, YS; Kim, YS; Lee, JH; Oh, SC; Seo, AR; Suh, SY, 2013) |
| " An inverse association between coffee consumption and all-cause mortality was maintained irrespective of age, overweight status, alcohol drinking, smoking status, and caffeine content of coffee." | 5.01 | Coffee consumption and all-cause and cause-specific mortality: a meta-analysis by potential modifiers. ( Giovannucci, E; Je, Y; Kim, Y, 2019) |
| " However, caffeine at high doses can increase anxiety, insomnia, calcium loss and possibly the risk of fractures." | 4.89 | Coffee and tea: perks for health and longevity? ( Bhatti, SK; Lavie, CJ; O'Keefe, JH, 2013) |
| " We propose that tumor protection is to a large extent due to (a) inhibition of antitumor T cells by hypoxia-driven accumulation of extracellular adenosine in local tumor microenvironment and due to (b) T regulatory cell-produced extracellular adenosine." | 4.84 | Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia. ( Kjaergaard, J; Lukashev, D; Ohta, A; Sitkovsky, MV, 2008) |
| " Caffeine is used for the treatment of apnea of prematurity and as an additive in several analgesics and migraine remedies, and as a panacea for hyperkinetic children." | 4.77 | Caffeine: a new look at an age-old drug. ( Gupta, P; Somani, SM, 1988) |
| " After cocktail alone or in combination with adavosertib administration, 24-h pharmacokinetic sampling occurred for probe substrates and their respective metabolites paraxanthine, 5-hydroxyomeprazole (5-HO), and 1'-hydroxymidazolam (1'-HM)." | 3.30 | Phase I study to assess the effect of adavosertib (AZD1775) on the pharmacokinetics of substrates of CYP1A2, CYP2C19, and CYP3A in patients with advanced solid tumors. ( Ah-See, ML; Edenfield, WJ; Lewis, LD; Li, Y; Mugundu, GM; Nadeau, L; Någård, M; Ottesen, LH; Safran, HP; Strauss, J; Wise-Draper, T, 2023) |
| "This phase 1, open-label, crossover study sought to evaluate drug-drug interactions between tivantinib and cytochrome P450 (CYP) substrates and tivantinib and P-glycoprotein." | 2.87 | Evaluation of the pharmacokinetic drug interaction potential of tivantinib (ARQ 197) using cocktail probes in patients with advanced solid tumours. ( Gajee, R; Papadopoulos, KP; Puzanov, I; Strickler, JH; Tachibana, M; Wang, Y; Zahir, H, 2018) |
| "Unfortunately, many types of cancers are extremely aggressive and untreatable since, in many cases, they are resistant to chemotherapy." | 2.82 | Natural products targeting into cancer hallmarks: An update on caffeine, theobromine, and (+)-catechin. ( Cadoná, FC; Dantas, RF; de Mello, GH; Silva-Jr, FP, 2022) |
| "Chemoprevention of cancer refers to the use of natural or synthetic compounds to abolish or perturb a variety of steps in tumor initiation, promotion, and progression." | 2.72 | Coffee in cancer chemoprevention: an updated review. ( Akhtar, S; Donati-Zeppa, S; Fimognari, C; Ismail, T; Layla, A; Sestili, P; Turrini, E, 2021) |
| "Cohorts of three or more adult cancer patients were administered oral GTE with water after meals one or three times daily for 4 weeks, to a maximum of 6 months, depending on disease response and patient tolerance." | 2.70 | Phase I trial of oral green tea extract in adult patients with solid tumors. ( Coldman, B; Glisson, BS; Hong, WK; Khuri, FR; Lee, JS; Newman, RA; Pisters, KM; Shin, DM, 2001) |
| "Caffeine has potential properties to counteract the central effects of morphine." | 2.70 | Effects of caffeine as an adjuvant to morphine in advanced cancer patients. A randomized, double-blind, placebo-controlled, crossover study. ( Casuccio, A; Mercadante, S; Serretta, R, 2001) |
| "Caffeine at lower (micromolar) and relatively non-toxic concentrations has been shown to promote anti-tumor immune response (A2 A) and to inhibit tumor angiogenesis (A3) and migration (A2B) by antagonizing adenosine receptors." | 2.58 | Mechanistic considerations in chemotherapeutic activity of caffeine. ( Nayak, PK; Tej, GNVC, 2018) |
| "The possible cancer-preventive activity of tea and tea polyphenols has been studied extensively." | 2.44 | Tea and cancer prevention: molecular mechanisms and human relevance. ( Ju, J; Lambert, JD; Lu, G; Sang, S; Yang, CS, 2007) |
| "Caffeine has also been reported to inhibit ATM and ATR kinases which leads to the disruption of multiple DNA damage-responsive cell cycle checkpoints and greatly sensitizes tumor cells to antitumor agents which induce genotoxic stress." | 2.44 | Modulation of cellular response to anticancer treatment by caffeine: inhibition of cell cycle checkpoints, DNA repair and more. ( Sabisz, M; Skladanowski, A, 2008) |
| " Among the different activities of EGCG observed in cell culture systems, we need to select the physiologically relevant ones based on the biological importance of the target as well as the effective concentration and whether the reaction can take place in vivo because of the limited bioavailability of EGCG." | 2.43 | Possible mechanisms of the cancer-preventive activities of green tea. ( Hou, Z; Ju, J; Lambert, JD; Lu, G; Sang, S; Yang, CS, 2006) |
| "Differential killing of the patient's cancer cells versus normal cells is a necessity for chemotherapy." | 2.43 | Tumor progression--targets for differential therapy. ( Pardee, AB, 2006) |
| "The role of tea in protection against cancer has been supported by ample evidence from studies in cell culture and animal models." | 2.42 | Tea and cancer prevention: studies in animals and humans. ( Chung, FL; Herzog, CR; Schwartz, J; Yang, YM, 2003) |
| "The large differences in cancer rates among countries, striking changes in these rates among migrating populations, and rapid changes over time within countries indicate that some aspect of lifestyle or environment is largely responsible for the common cancers in Western countries." | 2.41 | Diet and cancer. ( Willett, WC, 2000) |
| "Many of cancers are caused by lifestyle elements." | 2.41 | Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols. ( Chung, FL; Weisburger, JH, 2002) |
| "Several human heritable cancer-prone syndromes known to alter DNA stability have been found to have defects in checkpoint surveillance pathways." | 2.40 | Cell cycle control, checkpoint mechanisms, and genotoxic stress. ( Kaufmann, WK; Paules, RS; Shackelford, RE, 1999) |
| "Post-treatment with caffeine greatly diminishes the yields by 4NQO of mutants in E." | 2.36 | A test for mutation theory of cancer: carcinogenesis by misrepair of DNA damaged by 4-nitroquinoline 1-oxide. ( Kondo, S, 1977) |
| "Depression and cancer are both prevalent diseases worldwide." | 1.91 | Caffeine intake is associated with less severe depressive symptoms in noncancer populations: an analysis based on NHANES 2007-2016. ( Dong, ZR; Li, T; Tan, SY; Wang, DX; Yan, LJ; Yan, YC; Yang, LS; Zhang, ZY, 2023) |
| "This study suggests that CAF-FA-CS-NPs (D4) in combination with MTX may be a promising candidate for cancer immunotherapy, by inhibiting A2aR signaling and leading to improved immune activation and anti-tumor activity of MTX." | 1.91 | Caffeine-folic acid-loaded-chitosan nanoparticles combined with methotrexate as a novel HepG2 immunotherapy targeting adenosine A2A receptor downstream cascade. ( Gaber, M; Ghareeb, D; Hamed, A; Hamed, M; Mohamed, TM; Nofal, MS, 2023) |
| "22,652 incident cancers occurred during 10." | 1.51 | Association between tea consumption and risk of cancer: a prospective cohort study of 0.5 million Chinese adults. ( Bian, Z; Chen, F; Chen, J; Chen, Y; Chen, Z; Guo, Y; Li, L; Li, X; Lv, J; Qiu, Z; Shen, Z; Wei, Y; Yang, L; Yu, C; Zhang, H, 2019) |
| "We found an increased risk of bladder cancer among never smokers who were heavy filtered or total coffee consumers, and an increased risk of stomach cancer in never smokers who were heavy boiled coffee consumers." | 1.48 | Coffee consumption and risk of rare cancers in Scandinavian countries. ( Braaten, T; Lindahl, B; Lukic, M; Nilsson, LM; Skeie, G, 2018) |
| "The preventive effect of coffee on cancer at different sites has been reported, but the effect on all-sites cancer incidence has not been extensively investigated." | 1.46 | Association between coffee consumption and all-sites cancer incidence and mortality. ( Ito, H; Katanoda, K; Kitamura, T; Kitamura, Y; Nakayama, T; Nishino, Y; Sado, J; Sobue, T; Suzuki, T; Tanaka, H; Tominaga, S; Tsuji, I, 2017) |
| " Induction of Cytochrome P450 (Cyp)1b1 in maternal liver may reduce bioavailability of DBP to the fetus as a mechanism of chemoprevention." | 1.35 | Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine. ( Castro, DJ; Dashwood, RH; Fischer, KA; Giovanini, JN; Löhr, CV; Orner, GA; Pereira, CB; Williams, DE; Yu, Z, 2008) |
| " This information led the authors to study the effect of long-term administration of caffeine (20 mg/kg/day; po for 22-27 consecutive days) on the development of EAC cells in relation to serum gonadal hormones (LH, FSH, 17-OH-beta-estradiol (E2) and progesterone) in adult Swiss albino female mice." | 1.34 | Long-term caffeine-induced inhibition of EAC cell progression in relation to gonadal hormonal status. ( Batabyal, SK; Mandal, A; Poddar, MK, 2007) |
| "(3)H-Adenosine metabolites were persistently retained after influx into the cell, predominantly as (3)H-adenosine triphosphate and (3)H-adenosine diphosphate." | 1.33 | In vitro evaluation of adenosine 5'-monophosphate as an imaging agent of tumor metabolism. ( Abraham, EH; Cho, SY; Engles, JM; Hilton, J; Polster, J; Wahl, RL, 2006) |
| "Research on cancer chemoprevention is an important approach for decreasing both the incidence and number of deaths from cancer." | 1.32 | Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture. ( Conney, AH, 2003) |
| "Acetaldehyde formation was determined by GC-FID analysis in the head space of incubation mixtures." | 1.31 | Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects. ( Castro, GD; Castro, JA; Costantini, MH; Delgado de Layño, AM, 2001) |
| "MCF-7 breast cancer, HT-29 colon cancer and UACC-375 melanoma)." | 1.29 | Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines. ( Alberts, DS; Guillén, JM; Krutzsch, M; Timmermann, BN; Valcic, S; Wächter, GA; Wymer, J, 1996) |
| "Our findings suggest that chromosomal abnormalities in childhood malignancies cannot generally be explained by the presence of FdU- or FdU plus caffeine-induced fragile sites." | 1.28 | Relationship between chemical-induced fragile sites and chromosomal breakpoints in malignant cells in children. ( Crist, WM; Douglass, EC; Lewis, S; Raimondi, SC; Ribeiro, RC; Valentine, M; Williams, DL, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (23.93) | 18.7374 |
| 1990's | 18 (15.38) | 18.2507 |
| 2000's | 35 (29.91) | 29.6817 |
| 2010's | 29 (24.79) | 24.3611 |
| 2020's | 7 (5.98) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 2 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 2 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 2 |
| Någård, M | 1 |
| Ah-See, ML | 1 |
| Strauss, J | 1 |
| Wise-Draper, T | 1 |
| Safran, HP | 1 |
| Nadeau, L | 1 |
| Edenfield, WJ | 1 |
| Lewis, LD | 1 |
| Ottesen, LH | 1 |
| Mugundu, GM | 1 |
| Yang, LS | 1 |
| Zhang, ZY | 1 |
| Yan, LJ | 1 |
| Yan, YC | 1 |
| Tan, SY | 1 |
| Wang, DX | 1 |
| Dong, ZR | 1 |
| Li, T | 2 |
| Hamed, A | 1 |
| Ghareeb, D | 1 |
| Mohamed, TM | 1 |
| Hamed, M | 1 |
| Nofal, MS | 1 |
| Gaber, M | 1 |
| Schaf, J | 1 |
| Damstra-Oddy, J | 1 |
| Williams, RSB | 1 |
| Visser, E | 1 |
| Geleijnse, JM | 1 |
| de Roos, B | 1 |
| Ismail, T | 1 |
| Donati-Zeppa, S | 1 |
| Akhtar, S | 1 |
| Turrini, E | 1 |
| Layla, A | 1 |
| Sestili, P | 1 |
| Fimognari, C | 1 |
| Pauwels, EKJ | 1 |
| Volterrani, D | 1 |
| Cadoná, FC | 1 |
| Dantas, RF | 1 |
| de Mello, GH | 1 |
| Silva-Jr, FP | 1 |
| Sado, J | 1 |
| Kitamura, T | 1 |
| Kitamura, Y | 1 |
| Sobue, T | 1 |
| Nishino, Y | 1 |
| Tanaka, H | 1 |
| Nakayama, T | 1 |
| Tsuji, I | 1 |
| Ito, H | 1 |
| Suzuki, T | 1 |
| Katanoda, K | 1 |
| Tominaga, S | 1 |
| Grosso, G | 1 |
| Godos, J | 1 |
| Galvano, F | 1 |
| Giovannucci, EL | 1 |
| Gökcen, BB | 1 |
| Şanlier, N | 1 |
| Tachibana, M | 1 |
| Papadopoulos, KP | 1 |
| Strickler, JH | 1 |
| Puzanov, I | 1 |
| Gajee, R | 1 |
| Wang, Y | 1 |
| Zahir, H | 1 |
| Lukic, M | 1 |
| Nilsson, LM | 1 |
| Skeie, G | 1 |
| Lindahl, B | 1 |
| Braaten, T | 1 |
| Cacciari, B | 1 |
| Spalluto, G | 1 |
| Federico, S | 1 |
| Tej, GNVC | 1 |
| Nayak, PK | 2 |
| Aghamohammadi, A | 1 |
| Akrami, SM | 1 |
| Yaghmaie, M | 1 |
| Rezaei, N | 1 |
| Azizi, G | 1 |
| Yaseri, M | 1 |
| Nosrati, H | 1 |
| Zaki-Dizaji, M | 1 |
| Kim, Y | 1 |
| Je, Y | 1 |
| Giovannucci, E | 1 |
| Li, X | 1 |
| Yu, C | 1 |
| Guo, Y | 1 |
| Bian, Z | 1 |
| Shen, Z | 1 |
| Yang, L | 1 |
| Chen, Y | 1 |
| Wei, Y | 1 |
| Zhang, H | 1 |
| Qiu, Z | 1 |
| Chen, F | 1 |
| Chen, Z | 1 |
| Lv, J | 1 |
| Li, L | 2 |
| Venkata Charan Tej, GN | 1 |
| Neogi, K | 1 |
| Verma, SS | 1 |
| Chandra Gupta, S | 1 |
| Suh, SY | 1 |
| Choi, YS | 1 |
| Oh, SC | 1 |
| Kim, YS | 1 |
| Cho, K | 1 |
| Bae, WK | 1 |
| Lee, JH | 1 |
| Seo, AR | 1 |
| Ahn, HY | 1 |
| Carroll, VS | 1 |
| Bhatti, SK | 1 |
| O'Keefe, JH | 1 |
| Lavie, CJ | 1 |
| Lu, GY | 1 |
| Huang, SM | 1 |
| Liu, ST | 1 |
| Liu, PY | 1 |
| Chou, WY | 1 |
| Lin, WS | 1 |
| Kim, J | 2 |
| Shim, J | 1 |
| Lee, CY | 1 |
| Lee, KW | 1 |
| Lee, HJ | 1 |
| Ludwig, IA | 1 |
| Clifford, MN | 1 |
| Lean, ME | 1 |
| Ashihara, H | 1 |
| Crozier, A | 1 |
| Ramin, C | 1 |
| Devore, EE | 1 |
| Wang, W | 1 |
| Pierre-Paul, J | 1 |
| Wegrzyn, LR | 1 |
| Schernhammer, ES | 1 |
| Lopez-Garcia, E | 1 |
| van Dam, RM | 2 |
| Li, TY | 1 |
| Rodriguez-Artalejo, F | 1 |
| Hu, FB | 1 |
| Castro, DJ | 1 |
| Yu, Z | 1 |
| Löhr, CV | 1 |
| Pereira, CB | 1 |
| Giovanini, JN | 1 |
| Fischer, KA | 1 |
| Orner, GA | 1 |
| Dashwood, RH | 1 |
| Williams, DE | 1 |
| Sabisz, M | 1 |
| Skladanowski, A | 1 |
| Sitkovsky, MV | 1 |
| Kjaergaard, J | 1 |
| Lukashev, D | 1 |
| Ohta, A | 2 |
| Nkondjock, A | 1 |
| Franco, R | 1 |
| Cheok, CF | 1 |
| Kua, N | 1 |
| Kaldis, P | 1 |
| Lane, DP | 1 |
| Xu, D | 1 |
| Cao, J | 1 |
| Qian, S | 1 |
| Hu, C | 1 |
| Weng, Q | 1 |
| Lou, J | 1 |
| Zhu, D | 1 |
| Zhu, H | 1 |
| Hu, Y | 1 |
| He, Q | 1 |
| Yang, B | 1 |
| Osowski, A | 1 |
| Pietrzak, M | 1 |
| Wieczorek, Z | 1 |
| Wieczorek, J | 1 |
| Sitkovsky, M | 1 |
| Floegel, A | 1 |
| Pischon, T | 1 |
| Bergmann, MM | 1 |
| Teucher, B | 1 |
| Kaaks, R | 1 |
| Boeing, H | 1 |
| McDonagh, EM | 1 |
| Wassenaar, C | 1 |
| David, SP | 1 |
| Tyndale, RF | 1 |
| Altman, RB | 1 |
| Whirl-Carrillo, M | 1 |
| Klein, TE | 1 |
| Oleaga, C | 1 |
| Ciudad, CJ | 1 |
| Noé, V | 1 |
| Izquierdo-Pulido, M | 1 |
| Hermansen, K | 1 |
| Krogholm, KS | 1 |
| Bech, BH | 1 |
| Dragsted, LO | 1 |
| Hyldstrup, L | 1 |
| Jørgensen, K | 1 |
| Larsen, ML | 1 |
| Tjønneland, AM | 1 |
| Nawrot, P | 1 |
| Jordan, S | 1 |
| Eastwood, J | 1 |
| Rotstein, J | 1 |
| Hugenholtz, A | 1 |
| Feeley, M | 1 |
| Manfredi, PL | 1 |
| Gonzales, GR | 1 |
| PARHON, CI | 1 |
| BABES, A | 1 |
| PETREA, I | 1 |
| KURSHEVA, AN | 1 |
| BERENBAUM, MC | 1 |
| CHIU, L | 1 |
| TRIEF, H | 1 |
| HIMMEL, A | 1 |
| INDULSKI, J | 1 |
| ALFRED, LJ | 1 |
| RAMSAY, AG | 1 |
| WHITE, DF | 1 |
| MUKHERJEE, HN | 1 |
| Chung, FL | 2 |
| Schwartz, J | 1 |
| Herzog, CR | 1 |
| Yang, YM | 1 |
| Conney, AH | 1 |
| Belka, C | 1 |
| Yang, CS | 4 |
| Sang, S | 3 |
| Lambert, JD | 3 |
| Hou, Z | 1 |
| Ju, J | 3 |
| Lu, G | 3 |
| Cho, SY | 1 |
| Polster, J | 1 |
| Engles, JM | 1 |
| Hilton, J | 1 |
| Abraham, EH | 1 |
| Wahl, RL | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Pardee, AB | 1 |
| Cao, L | 1 |
| Finkel, T | 1 |
| Mandal, A | 1 |
| Batabyal, SK | 1 |
| Poddar, MK | 1 |
| Daly, JW | 1 |
| Haacke, EM | 1 |
| Filleti, CL | 1 |
| Gattu, R | 1 |
| Ciulla, C | 1 |
| Al-Bashir, A | 1 |
| Suryanarayanan, K | 1 |
| Li, M | 1 |
| Latif, Z | 1 |
| DelProposto, Z | 1 |
| Sehgal, V | 1 |
| Torquato, V | 1 |
| Kanaparti, R | 1 |
| Jiang, J | 1 |
| Neelavalli, J | 1 |
| Takezawa, J | 1 |
| Ishimi, Y | 1 |
| Yamada, K | 1 |
| Xiao, H | 1 |
| Hao, X | 1 |
| Bhaskara, S | 1 |
| Chyla, BJ | 1 |
| Amann, JM | 1 |
| Knutson, SK | 1 |
| Cortez, D | 1 |
| Sun, ZW | 1 |
| Hiebert, SW | 1 |
| George, SE | 1 |
| Ramalakshmi, K | 1 |
| Mohan Rao, LJ | 1 |
| Yunis, JJ | 1 |
| Soreng, AL | 1 |
| Curatolo, PW | 1 |
| Robertson, D | 1 |
| James, JE | 1 |
| Stirling, KP | 1 |
| Hackenthal, E | 1 |
| Palm, PE | 1 |
| Arnold, EP | 1 |
| Nick, MS | 1 |
| Valentine, JR | 1 |
| Doerfler, TE | 1 |
| Kuroki, T | 1 |
| Parshad, R | 1 |
| Sanford, KK | 1 |
| Jones, GM | 1 |
| Tarone, RE | 1 |
| Stambaugh, JE | 1 |
| Tejada, F | 1 |
| Trudnowski, RJ | 1 |
| Sherin, K | 1 |
| Oser, BL | 1 |
| Ford, RA | 1 |
| Lamarine, RJ | 1 |
| Thompson, WG | 1 |
| Hegde, BM | 1 |
| Barone, JJ | 1 |
| Grice, HC | 1 |
| Suter, PM | 1 |
| Vetter, W | 1 |
| Vineis, P | 1 |
| Valcic, S | 1 |
| Timmermann, BN | 1 |
| Alberts, DS | 1 |
| Wächter, GA | 1 |
| Krutzsch, M | 1 |
| Wymer, J | 1 |
| Guillén, JM | 1 |
| Nehlig, A | 1 |
| Debry, G | 1 |
| Houston, DK | 1 |
| Johnson, MA | 1 |
| Daniel, TD | 1 |
| Poon, LW | 1 |
| Mozhayeva, MG | 1 |
| Kiselyov, KI | 1 |
| Shackelford, RE | 1 |
| Kaufmann, WK | 1 |
| Paules, RS | 1 |
| Carrillo, JA | 1 |
| Benítez, J | 1 |
| Homsi, J | 1 |
| Walsh, D | 1 |
| Nelson, KA | 1 |
| Willett, WC | 1 |
| Castro, GD | 1 |
| Delgado de Layño, AM | 1 |
| Costantini, MH | 1 |
| Castro, JA | 1 |
| Pisters, KM | 1 |
| Newman, RA | 1 |
| Coldman, B | 1 |
| Shin, DM | 1 |
| Hong, WK | 1 |
| Glisson, BS | 1 |
| Lee, JS | 1 |
| Pastera, J | 1 |
| Anzenbacher, P | 1 |
| Fiala, Z | 1 |
| Mercadante, S | 1 |
| Serretta, R | 1 |
| Casuccio, A | 1 |
| Yang, GY | 1 |
| Chung, JY | 1 |
| Lee, MJ | 1 |
| Li, C | 1 |
| Sarkaria, JN | 1 |
| Eshleman, JS | 1 |
| Weisburger, JH | 1 |
| Trosko, JE | 1 |
| Chu, EH | 1 |
| Kondo, S | 1 |
| Lehmann, AR | 1 |
| Kirk-Bell, S | 1 |
| Arlett, CF | 1 |
| Harcourt, SA | 1 |
| de Weerd-Kastelein, EA | 1 |
| Keijzer, W | 1 |
| Hall-Smith, P | 1 |
| Legeza, VI | 1 |
| Korytova, LI | 1 |
| Rakhmilevich, BM | 1 |
| Rambovskiĭ, AI | 1 |
| Hirvonen, L | 1 |
| Ribeiro, RC | 1 |
| Douglass, EC | 1 |
| Williams, DL | 1 |
| Raimondi, SC | 1 |
| Valentine, M | 1 |
| Lewis, S | 1 |
| Crist, WM | 1 |
| Stavric, B | 1 |
| Grossarth-Maticek, R | 1 |
| Eysenck, HJ | 1 |
| Somani, SM | 1 |
| Gupta, P | 1 |
| Schreiber, GB | 1 |
| Robins, M | 1 |
| Maffeo, CE | 1 |
| Masters, MN | 1 |
| Bond, AP | 1 |
| Morganstein, D | 1 |
| Strubelt, O | 1 |
| Pozniak, PC | 1 |
| Van Balgooy, JN | 1 |
| Roberts, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial[NCT02832336] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2016-10-01 | Completed | ||
| Efficacy of Caffeine as an Adjuvant to Opioid Therapy in Cancer Pain: a Randomized, Double-blind, Placebo-controlled Trial[NCT00879775] | Phase 2 | 41 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Does Caffeine Enhance Bowel Recovery After Colorectal Surgery?[NCT03097900] | Phase 2 | 70 participants (Actual) | Interventional | 2017-11-02 | Completed | ||
| The Effect of Metabolism-Boosting Beverages on 24 Hr Energy Expenditure[NCT01029236] | 30 participants (Actual) | Interventional | 2007-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a higher level of fatigue. (NCT00879775)
Timeframe: two days
| Intervention | scores (Mean) |
|---|---|
| Caffeine | 3.61 |
| Placebo | 3.55 |
Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a better health-related quality of life. (NCT00879775)
Timeframe: two days
| Intervention | scores (Mean) |
|---|---|
| Caffeine | 4.83 |
| Placebo | 4.45 |
Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a higher level of sleep disturbance. (NCT00879775)
Timeframe: two days
| Intervention | scores (Mean) |
|---|---|
| Caffeine | 3.53 |
| Placebo | 3.80 |
Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a higher level of impact of symptom burden to daily life. (NCT00879775)
Timeframe: two days
| Intervention | scores (Mean) | ||||
|---|---|---|---|---|---|
| Daily living | Mood | Work | Interpersonal relationship | Gait ability | |
| Caffeine | 5.17 | 5.61 | 5.56 | 4.61 | 4.39 |
| Placebo | 5.95 | 5.60 | 6.75 | 4.65 | 5.50 |
Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; higher scores represent higher levels of pain, and possible side effects (drowsiness, confusion, nausea) of opioids. (NCT00879775)
Timeframe: two days
| Intervention | scores (Mean) | |||
|---|---|---|---|---|
| Pain | Drowsiness | Confusion | Nausea | |
| Caffeine | 2.22 | 2.83 | 1.89 | 2.28 |
| Placebo | 3.10 | 3.05 | 2.20 | 1.80 |
51 reviews available for caffeine and Benign Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Dictyostelium discoideum as a pharmacological model system to study the mechanisms of medicinal drugs and natural products.
Topics: Animals; Anti-Infective Agents; Bacterial Infections; Biological Products; Bipolar Disorder; Caffein | 2019 |
Inter-Individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: A Critical Review.
Topics: Alcohol Drinking; Caffeine; Cardiovascular Diseases; Coffee; Female; Humans; Male; Neoplasms; Polymo | 2020 |
Coffee in cancer chemoprevention: an updated review.
Topics: Animals; Caffeine; Chemoprevention; Chlorogenic Acid; Coffee; Diterpenes; Humans; Neoplasms | 2021 |
Coffee Consumption and Cancer Risk: An Assessment of the Health Implications Based on Recent Knowledge.
Topics: Caffeine; Coffee; Humans; Neoplasms | 2021 |
Natural products targeting into cancer hallmarks: An update on caffeine, theobromine, and (+)-catechin.
Topics: Antioxidants; Biological Products; Caffeine; Catechin; Humans; Neoplasms; Theobromine | 2022 |
Coffee, Caffeine, and Health Outcomes: An Umbrella Review.
Topics: Caffeine; Cardiovascular Diseases; Coffee; Diabetes Mellitus, Type 2; Female; Humans; Male; Neoplasm | 2017 |
Coffee consumption and disease correlations.
Topics: Caffeine; Cardiovascular Diseases; Chlorogenic Acid; Coffee; Diabetes Mellitus, Type 2; Diterpenes; | 2019 |
A2A Adenosine Receptor Antagonists as Therapeutic Candidates: Are They Still an Interesting Challenge?
Topics: Adenosine A2 Receptor Antagonists; Bridged Bicyclo Compounds; Caffeine; Dopamine Agents; Humans; Neo | 2018 |
Mechanistic considerations in chemotherapeutic activity of caffeine.
Topics: Antineoplastic Agents; Apoptosis; Caffeine; Humans; Immunologic Factors; Neoplasms; Neovascularizati | 2018 |
Coffee consumption and all-cause and cause-specific mortality: a meta-analysis by potential modifiers.
Topics: Alcohol Drinking; Caffeine; Cardiovascular Diseases; Causality; Cause of Death; Coffee; Europe; Fema | 2019 |
Coffee and tea: perks for health and longevity?
Topics: Antioxidants; Anxiety; Blood Glucose; Blood Pressure; Caffeine; Calcium; Cardiovascular Diseases; Co | 2013 |
Cocoa phytochemicals: recent advances in molecular mechanisms on health.
Topics: Animals; Biological Availability; Cacao; Caffeine; Cardiovascular Diseases; Diabetes Mellitus; Flavo | 2014 |
Coffee: biochemistry and potential impact on health.
Topics: Alkaloids; Animals; Antioxidants; Caffeine; Cardiovascular Diseases; Chlorogenic Acid; Coffee; Diabe | 2014 |
Modulation of cellular response to anticancer treatment by caffeine: inhibition of cell cycle checkpoints, DNA repair and more.
Topics: Animals; Antineoplastic Agents; Caffeine; Cell Cycle; DNA Repair; Humans; Interleukin-8; Molecular S | 2008 |
Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia.
Topics: Adenosine; Animals; Caffeine; CD8-Positive T-Lymphocytes; Humans; Hypoxia; Hypoxia-Inducible Factor | 2008 |
Coffee consumption and the risk of cancer: an overview.
Topics: Antioxidants; Caffeine; Coffee; Female; Humans; Male; Neoplasms; Protective Agents; Risk | 2009 |
[Coffee and cancer].
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Anticarcinogenic Agents; Caffeine; Cell Trans | 2008 |
Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Caffeine; Cardiovascular Diseases; Causality; Central Ne | 2008 |
Methylxanthines, inflammation, and cancer: fundamental mechanisms.
Topics: Acute Disease; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Coffee; Hepatitis; Humans; Live | 2011 |
PharmGKB summary: very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6.
Topics: Aryl Hydrocarbon Hydroxylases; Caffeine; Communicable Diseases; Cytochrome P-450 CYP2A6; Humans; Neo | 2012 |
Effects of caffeine on human health.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Bone and Bones; Caffeine; Calcium; Cardiovascula | 2003 |
Symptomatic uses of caffeine in patients with cancer.
Topics: Analgesics, Opioid; Caffeine; Humans; Neoplasms; Pain | 2003 |
Tea and cancer prevention: studies in animals and humans.
Topics: Animals; Apoptosis; Caffeine; Catechin; Clinical Trials as Topic; Flavonoids; Humans; Lung Neoplasms | 2003 |
Possible mechanisms of the cancer-preventive activities of green tea.
Topics: Animals; Caffeine; Catechin; DNA Modification Methylases; Enzyme Inhibitors; Humans; Neoplasms; Prot | 2006 |
The enigmatic effects of caffeine in cell cycle and cancer.
Topics: Animals; Apoptosis; Caffeine; Cell Cycle; Cell Proliferation; Cells, Cultured; DNA Damage; Dose-Resp | 2007 |
Tumor progression--targets for differential therapy.
Topics: Antineoplastic Agents; Apoptosis; Caffeine; Cell Cycle; Cell Proliferation; Disease Progression; Dru | 2006 |
Tea and cancer prevention: molecular mechanisms and human relevance.
Topics: Animals; Anticarcinogenic Agents; Caffeine; Catechin; Humans; Molecular Structure; Neoplasms; Tea | 2007 |
Caffeine analogs: biomedical impact.
Topics: Alzheimer Disease; Asthma; Biomedical Research; Caffeine; Calcium; Central Nervous System Stimulants | 2007 |
Cancer prevention by tea and tea polyphenols.
Topics: Anticarcinogenic Agents; Beverages; Caffeine; Flavonoids; Humans; Neoplasms; Phenols; Polyphenols; T | 2008 |
The health consequences of caffeine.
Topics: Brain; Caffeine; Coffee; Digestive System; Drug Tolerance; Female; Fibrocystic Breast Disease; Hemod | 1983 |
Caffeine: a survey of some of the known and suspected deleterious effects of habitual use.
Topics: Abnormalities, Drug-Induced; Anxiety Disorders; Behavior Therapy; Caffeine; Coffee; Diagnosis, Diffe | 1983 |
[How important are combined analgesic preparations?].
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Combinations; Humans; Kidney Dis | 1984 |
In vitro carcinogenesis by 4-nitroquinoline 1-oxide and related compounds.
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; Carcinogens; Cell Cycle; Cell Transformation, Neoplasti | 1981 |
Selected health and behavioral effects related to the use of caffeine.
Topics: Behavior; Caffeine; Carbonated Beverages; Cardiovascular Diseases; Coffee; Humans; Neoplasms; Nonpre | 1994 |
Coffee: brew or bane?
Topics: Caffeine; Cardiovascular Diseases; Coffee; Hip Fractures; Humans; Lipids; Neoplasms; Risk Factors; T | 1994 |
[Coffee and caffeine. Various selected aspects for everyday practice].
Topics: Arrhythmias, Cardiac; Blood Pressure; Caffeine; Coffee; Humans; Neoplasms; Risk Factors; Xanthines | 1993 |
Coffee and cancer: a review of human and animal data.
Topics: Animals; Caffeine; Coffee; Dose-Response Relationship, Drug; Gastrointestinal Neoplasms; Humans; Inc | 1996 |
Cell cycle control, checkpoint mechanisms, and genotoxic stress.
Topics: Animals; Ataxia Telangiectasia; Caffeine; Cell Cycle; Cyclins; DNA Repair; Genes, p53; Humans; Neopl | 1999 |
Psychostimulants in supportive care.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Child; Dextroamphetamine; Ephedrine; Humans; Men | 2000 |
Diet and cancer.
Topics: Caffeine; Diet; Dietary Fats; Dietary Fiber; Dietary Supplements; Energy Intake; Ethanol; Fruit; Hum | 2000 |
Tea and tea polyphenols in cancer prevention.
Topics: Animals; Biological Availability; Caffeine; Catechin; Disease Models, Animal; Flavonoids; Humans; In | 2001 |
ATM as a target for novel radiosensitizers.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle; Cell Cycle Prot | 2001 |
Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols.
Topics: Animals; Antioxidants; Caffeine; Carcinogens; Chronic Disease; Diet; Digestive System; Enzyme Induct | 2002 |
The role of DNA repair and somatic mutation in carcinogenesis.
Topics: Aging; Base Sequence; Caffeine; Carcinogens; Cell Differentiation; Cell Division; Chromatin; Chromos | 1975 |
A test for mutation theory of cancer: carcinogenesis by misrepair of DNA damaged by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; Cell Transformation, Neoplastic; DNA; DNA Repair; DNA, | 1977 |
[Coffee and health].
Topics: Anxiety Disorders; Blood Pressure; Caffeine; Central Nervous System; Coffee; Diuresis; Humans; Neopl | 1992 |
An update on research with coffee/caffeine (1989-1990).
Topics: Animals; Antimutagenic Agents; Caffeine; Cholesterol; Coffee; Coronary Disease; Female; Humans; Infa | 1992 |
Caffeine: a new look at an age-old drug.
Topics: Apnea; Arteriosclerosis; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Neoplasms | 1988 |
[Toxicity of coffee and caffeine].
Topics: Animals; Caffeine; Coffee; Female; Fibrocystic Breast Disease; Humans; Male; Mice; Mutagens; Neoplas | 1987 |
The carcinogenicity of caffeine and coffee: a review.
Topics: Breast Neoplasms; Caffeine; Coffee; Epidemiologic Methods; Female; Humans; Intestinal Neoplasms; Kin | 1985 |
6 trials available for caffeine and Benign Neoplasms
| Article | Year |
|---|---|
Phase I study to assess the effect of adavosertib (AZD1775) on the pharmacokinetics of substrates of CYP1A2, CYP2C19, and CYP3A in patients with advanced solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochr | 2023 |
Evaluation of the pharmacokinetic drug interaction potential of tivantinib (ARQ 197) using cocktail probes in patients with advanced solid tumours.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B | 2018 |
Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial.
Topics: Aged; Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Chemotherapy, Adjuvant; Doubl | 2013 |
Double-blind comparisons of zomepirac and oxycodone with APC in cancer pain.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug C | 1980 |
Phase I trial of oral green tea extract in adult patients with solid tumors.
Topics: Administration, Oral; Adult; Aged; Caffeine; Dose-Response Relationship, Drug; Drugs, Chinese Herbal | 2001 |
Effects of caffeine as an adjuvant to morphine in advanced cancer patients. A randomized, double-blind, placebo-controlled, crossover study.
Topics: Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over Studies; Doub | 2001 |
60 other studies available for caffeine and Benign Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Caffeine intake is associated with less severe depressive symptoms in noncancer populations: an analysis based on NHANES 2007-2016.
Topics: Caffeine; Depression; Humans; Linear Models; Neoplasms; Nutrition Surveys | 2023 |
Caffeine-folic acid-loaded-chitosan nanoparticles combined with methotrexate as a novel HepG2 immunotherapy targeting adenosine A2A receptor downstream cascade.
Topics: Adenosine; Caffeine; Chitosan; Folic Acid; Humans; Immunotherapy; Methotrexate; Molecular Docking Si | 2023 |
Association between coffee consumption and all-sites cancer incidence and mortality.
Topics: Adult; Aged; Caffeine; Female; Humans; Incidence; Male; Middle Aged; Neoplasms; Proportional Hazards | 2017 |
Coffee consumption and risk of rare cancers in Scandinavian countries.
Topics: Aged; Caffeine; Coffee; Female; Humans; Male; Middle Aged; Neoplasms; Norway; Proportional Hazards M | 2018 |
Individual Radiosensitivity Assessment of the Families of
Topics: Adolescent; Adult; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Atherosclerosis; C | 2018 |
Association between tea consumption and risk of cancer: a prospective cohort study of 0.5 million Chinese adults.
Topics: Adult; Aged; Alcohol Drinking; Asian People; Breast Neoplasms; Caffeine; China; Colorectal Neoplasms | 2019 |
Caffeine-enhanced anti-tumor immune response through decreased expression of PD1 on infiltrated cytotoxic T lymphocytes.
Topics: Animals; Caffeine; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Interferon-ga | 2019 |
In praise of coffee ... and caffeine.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Coffee; Dementia; Humans; Mice; Neoplasms; Spe | 2013 |
Caffeine induces tumor cytotoxicity via the regulation of alternative splicing in subsets of cancer-associated genes.
Topics: Alternative Splicing; Animals; Antineoplastic Combined Chemotherapy Protocols; Caffeine; Cell Line, | 2014 |
Night shift work at specific age ranges and chronic disease risk factors.
Topics: Adult; Age Factors; Body Mass Index; Caffeine; Cardiovascular Diseases; Chronic Disease; Energy Inta | 2015 |
The relationship of coffee consumption with mortality.
Topics: Caffeine; Cardiovascular Diseases; Cause of Death; Coffee; Drinking Behavior; Female; Follow-Up Stud | 2008 |
Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine.
Topics: Animals; Anticarcinogenic Agents; Benzopyrenes; Caffeine; Carcinogens; Catechin; Chemoprevention; Fe | 2008 |
Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53.
Topics: Apoptosis; Aurora Kinases; Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; C | 2010 |
5k, a novel β-O-demethyl-epipodophyllotoxin analogue, inhibits the proliferation of cancer cells in vitro and in vivo via the induction of G2 arrest and apoptosis.
Topics: Animals; Apoptosis; Caffeine; Caspases; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; D | 2011 |
Natural compounds in the human diet and their ability to bind mutagens prevents DNA-mutagen intercalation.
Topics: Acridine Orange; Antineoplastic Agents; Biophysical Phenomena; Caffeine; Carcinogens; Chlorophyll; C | 2010 |
Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study.
Topics: Adult; Aged; Caffeine; Cardiovascular Diseases; Coffee; Cohort Studies; Diabetes Mellitus, Type 2; F | 2012 |
Coffee and health. The latest buzz.
Topics: Alzheimer Disease; Blood Pressure; Bone and Bones; Caffeine; Central Nervous System Stimulants; Coff | 2012 |
Coffee polyphenols change the expression of STAT5B and ATF-2 modifying cyclin D1 levels in cancer cells.
Topics: Activating Transcription Factor 2; Caffeic Acids; Caffeine; Cell Line, Tumor; Coffee; Cyclin D1; Gen | 2012 |
[Coffee can protect against disease].
Topics: Alzheimer Disease; Anxiety; Caffeine; Cardiovascular Diseases; Coffee; Cognition; Diabetes Mellitus, | 2012 |
The action exercised by the thymus and several neurotropic substances in experimental cancer.
Topics: Animals; Benzoates; Caffeine; Humans; Neoplasms; Neoplasms, Experimental; Phenobarbital; Thymus Extr | 1957 |
[Effect of modified conditions of the central nervous system on developmental characteristics of M-1 tumor in rats].
Topics: Animals; Caffeine; Central Nervous System; Neoplasms; Neoplasms, Experimental; Rats | 1958 |
A screen for agents inhibiting the immune response and the growth of tumours.
Topics: Alloxan; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antibody Formation; Antineoplastic Agen | 1962 |
[EFFECTS OF SODIUM BROMIDE AND CAFFEINE ON THE INDUCTION OF PITUITARY ADENOMAS BY ESTROGEN IN CHINESE HAMSTERS].
Topics: Adenoma; Animals; Bromides; Caffeine; Carcinogens; Cricetinae; Cricetulus; Estradiol; Estrogens; Neo | 1963 |
[DIAGNOSTIC TESTS IN PRECANCEROUS CONDITIONS OF THE STOMACH].
Topics: Caffeine; Diagnostic Tests, Routine; Gastric Acidity Determination; Gastroscopy; Histamine; Humans; | 1964 |
INTERACTION OF SOLUBLE COMPLEXES OF TRITIATED 3,4-BENZOPYRENE AND ANIMAL CELLS IN VITRO.
Topics: Benzo(a)pyrene; Benzopyrenes; Caffeine; In Vitro Techniques; Metabolism; Mice; Neoplasms; Research; | 1964 |
PHENACETIN NEPHROPATHY.
Topics: Acidosis; Animals; Aspirin; Bacteriuria; Biological Transport; Caffeine; Codeine; Dogs; Drug Therapy | 1965 |
TREATMENT OF CANCER OF THE INTESTINAL TRACT WITH A COMPLEX COMPOUND OF PHOSPHOTUNGSTIC PHOSPHOMOLYBDIC ACIDS AND CAFFEINE.
Topics: Antineoplastic Agents; Caffeine; Geriatrics; Humans; Intestinal Neoplasms; Molybdenum; Neoplasms; Ph | 1965 |
Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture.
Topics: Animals; Anticarcinogenic Agents; Caffeine; Catechin; Chemoprevention; Curcumin; Enzyme Induction; E | 2003 |
Coffee: for most, it's safe. Coffee has been blamed for everything from moral turpitude to cancer. But none of the bad raps have stuck. Coffee may even be good for you.
Topics: Caffeine; Cardiovascular System; Coffee; Diabetes Mellitus, Type 2; Female; Homocysteine; Humans; Li | 2004 |
The fate of irradiated tumor cells.
Topics: Caffeine; Cell Death; Cyclin-Dependent Kinase Inhibitor p21; G2 Phase; Humans; Neoplasms; Radiation | 2006 |
In vitro evaluation of adenosine 5'-monophosphate as an imaging agent of tumor metabolism.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Monophosphate; Caffeine; Carbon Radioisotopes; Cell Line, Tumo | 2006 |
Cancer gets the Chk'ered flag.
Topics: Animals; Caffeine; Cellular Senescence; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; Humans | 2006 |
Long-term caffeine-induced inhibition of EAC cell progression in relation to gonadal hormonal status.
Topics: Animals; Caffeine; Cell Line, Tumor; Cell Proliferation; Female; Gonadal Steroid Hormones; Mice; Mic | 2007 |
New algorithm for quantifying vascular changes in dynamic contrast-enhanced MRI independent of absolute T1 values.
Topics: Adult; Algorithms; Artifacts; Blood Circulation; Caffeine; Central Nervous System Stimulants; Contra | 2007 |
Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells.
Topics: Acetylcysteine; Boronic Acids; Caffeine; Cells, Cultured; Cisplatin; Cysteine Proteinase Inhibitors; | 2008 |
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control.
Topics: Animals; Apoptosis; Caffeine; Cells, Cultured; DNA Damage; DNA Repair; Fibroblasts; Gene Expression | 2008 |
A perception on health benefits of coffee.
Topics: Caffeine; Calcium; Cardiovascular Diseases; Central Nervous System Diseases; Coffee; Health Status; | 2008 |
Constitutive fragile sites and cancer.
Topics: Adolescent; Adult; Animals; Caffeine; Cells, Cultured; Child; Chromosome Fragile Sites; Chromosome F | 1984 |
Two-year toxicity/carcinogenicity study of fresh-brewed coffee in rats initially exposed in utero.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Caffeine; Calcium; Carcinogens; F | 1984 |
Caffeine labeling. Council on Scientific Affairs. American Medical Association.
Topics: Abnormalities, Drug-Induced; Behavior; Cacao; Caffeine; Carbonated Beverages; Coffee; Female; Fibroc | 1984 |
Neoplastic transformation of human cells in culture associated with deficient repair of light-induced chromosomal DNA damage.
Topics: Caffeine; Cell Cycle; Cell Transformation, Neoplastic; Cells, Cultured; Chromatids; DNA Repair; Huma | 1982 |
Smoking cessation: the physician's role.
Topics: Asthma; Caffeine; Cerebrovascular Disorders; Coronary Disease; Humans; Male; Motivation; Neoplasms; | 1982 |
Caffeine: an update.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Behavior; Caffeine; Child; Child, Preschool | 1981 |
Coffee, cardiac disease, cancer and common sense.
Topics: Animals; Caffeine; Coffee; Coronary Disease; Female; Humans; Neoplasms; Pregnancy; Pregnancy Complic | 1994 |
Seventh International Caffeine Workshop, Santorini, Greece 13-17 June 1993.
Topics: Adolescent; Adult; Bone Density; Caffeine; Calcium; Carbonated Beverages; Cardiovascular Diseases; C | 1994 |
Hypothesis: coffee consumption, N-acetyltransferase phenotype, and cancer.
Topics: Acetylation; Arylamine N-Acetyltransferase; Breast Neoplasms; Caffeine; Coffee; Colonic Neoplasms; F | 1993 |
Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines.
Topics: Caffeine; Catechin; Cell Division; Drug Screening Assays, Antitumor; Humans; Neoplasms; Plant Extrac | 1996 |
Health and dietary characteristics of supplement users in an elderly population.
Topics: Aged; Aged, 80 and over; Aging; Alcohol Drinking; Ascorbic Acid; Caffeine; Calcium, Dietary; Cardiov | 1997 |
Involvement of Ca2+-induced Ca2+ release in the biphasic Ca2+ response evoked by readdition of Ca2+ to the medium after UTP-induced store depletion in A431 cells.
Topics: Caffeine; Calcium; Culture Media; Endothelium; Humans; Inositol 1,4,5-Trisphosphate; Neoplasms; Ryan | 1998 |
Are antipsychotic drugs potentially chemopreventive agents for cancer?
Topics: Adult; Antineoplastic Agents; Antipsychotic Agents; Benzodiazepines; Caffeine; Carcinogens; Chemopre | 1999 |
Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects.
Topics: Acetaldehyde; Alcohol Drinking; Allopurinol; Animals; Antimetabolites; Caffeine; Carcinogens; Chroma | 2001 |
[Phenotyping of cytochrome P-450 1A2 and N-acetyltransferase (NAT2) using the in vivo caffeine test as a tool for determining individual susceptibility to selected xenobiotics].
Topics: Arylamine N-Acetyltransferase; Caffeine; Carcinogens; Chromatography, High Pressure Liquid; Cytochro | 1999 |
Repair of ultraviolet light damage in a variety of human fibroblast cell strains.
Topics: Caffeine; Cell Survival; Cells, Cultured; DNA Repair; DNA Replication; DNA, Neoplasm; Fibroblasts; H | 1977 |
Editorial: Caffeine, coffee, and cancer.
Topics: Animals; Caffeine; Coffee; Humans; Mice; Neoplasms | 1976 |
[The use of diksafen for curing the neurotoxic reactions of cancer patients undergoing radiation and chemotherapy].
Topics: Adolescent; Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Benzamides | 1992 |
Relationship between chemical-induced fragile sites and chromosomal breakpoints in malignant cells in children.
Topics: Adolescent; Adult; Caffeine; Child; Child, Preschool; Chromosome Aberrations; Chromosome Fragile Sit | 1992 |
Coca-Cola, cancers, and coronaries: personality and stress as mediating factors.
Topics: Alcohol Drinking; Caffeine; Carbonated Beverages; Coronary Disease; England; Female; Follow-Up Studi | 1991 |
Confounders contributing to the reported associations of coffee or caffeine with disease.
Topics: Adult; Aged; Caffeine; Coffee; Coronary Disease; Disease Susceptibility; Drinking Behavior; Female; | 1988 |
Methods for study of imidazole compounds and application to brain and cancer cells.
Topics: Animals; Autoradiography; Brain Chemistry; Bromine; Caffeine; Carcinoma, Ehrlich Tumor; Cells; Chemi | 1973 |