caffeine has been researched along with Ataxia Telangiectasia Syndrome in 28 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The frequencies of caffeine-induced chromosomal aberrations (CA), mainly chromatid (CdB) and chromosome (CB) breaks, were studied in lymphocyte cultures derived from 6 obligatory heterozygotes and 1 homozygote of ataxia telangiectasia (AT), and from 4 control adult healthy persons." | 7.68 | Increased frequency of chromatid breaks in lymphocytes of heterozygotes of ataxia telangiectasia after in vitro treatment with caffeine. ( Ignatowicz, R; Kotecki, M; Pawlak, AL, 1990) |
| "The effect of post-treatments with caffeine in G2 on the frequency of X-ray-induced chromatid aberrations was studied in normal and ataxia telangiectasia (A-T) fibroblast and lymphoblastoid cells." | 7.67 | Effect of caffeine in G2 on X-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells. ( Hansson, K; Kihlman, BA; Natarajan, AT, 1984) |
| "Caffeine has a similar overall effect in control and A-T cell lines in reducing the G2 arrest observed after ionizing radiation." | 5.27 | Effect of caffeine on gamma-ray-induced G2 delay in ataxia telangiectasia. ( Bates, PR; Imray, FP; Lavin, MF, 1985) |
| " Studies involving cells treated with caffeine, cells from humans with the genetic disease ataxia telangiectasia, and cells that are deficient in p53 show no correlation between G1 delay and increased cell killing or chromosome damage in response to ionizing radiation." | 4.79 | Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective. ( Murnane, JP, 1995) |
| "The frequencies of caffeine-induced chromosomal aberrations (CA), mainly chromatid (CdB) and chromosome (CB) breaks, were studied in lymphocyte cultures derived from 6 obligatory heterozygotes and 1 homozygote of ataxia telangiectasia (AT), and from 4 control adult healthy persons." | 3.68 | Increased frequency of chromatid breaks in lymphocytes of heterozygotes of ataxia telangiectasia after in vitro treatment with caffeine. ( Ignatowicz, R; Kotecki, M; Pawlak, AL, 1990) |
| "The effect of post-treatments with caffeine in G2 on the frequency of X-ray-induced chromatid aberrations was studied in normal and ataxia telangiectasia (A-T) fibroblast and lymphoblastoid cells." | 3.67 | Effect of caffeine in G2 on X-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells. ( Hansson, K; Kihlman, BA; Natarajan, AT, 1984) |
| "Several human heritable cancer-prone syndromes known to alter DNA stability have been found to have defects in checkpoint surveillance pathways." | 2.40 | Cell cycle control, checkpoint mechanisms, and genotoxic stress. ( Kaufmann, WK; Paules, RS; Shackelford, RE, 1999) |
| "Treatment with caffeine that abrogates the G(2) checkpoint without significantly affecting DSB rejoining increases metaphase chromosome damage of normal cells to the AT level but leaves unchanged interphase chromosome damage in G(2)." | 1.33 | Checkpoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells. ( Iliakis, G; Manola, KN; Pantelias, GE; Terzoudi, GI, 2005) |
| "Caffeine does not inhibit Chk2/Cds1 activity directly, but rather, blocks the activation of Chk2/Cds1 by inhibiting ATM kinase activity." | 1.31 | Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. ( Chaturvedi, P; Johanson, RA; Khanna, KK; Mattern, MR; Mishra, R; Scott, SP; Spring, K; Winkler, JD; Zhou, BB, 2000) |
| "Caffeine was found to potentiate X-ray-induced killing of human diploid fibroblasts from a normal subject and an ataxia-telangiectasia (AT) patient when it was present at 2 mM concentration for 30 to 66 hr postirradiation." | 1.27 | The potentiation by caffeine of X-ray damage to cultured human skin fibroblasts from normal subjects and ataxia-telangiectasia patients. ( Furcinitti, PS, 1983) |
| "Caffeine has a similar overall effect in control and A-T cell lines in reducing the G2 arrest observed after ionizing radiation." | 1.27 | Effect of caffeine on gamma-ray-induced G2 delay in ataxia telangiectasia. ( Bates, PR; Imray, FP; Lavin, MF, 1985) |
| "In the frequencies of induced chromosomal aberrations following X-rays, there was heterogeneity in response, with one cell line showing a definite intermediate response." | 1.26 | Attempts to detect ataxia telangiectasia (AT) heterozygotes by cytogenetical techniques. ( Meijers, M; Natarajan, AT; Simons, JW; van Zeeland, AA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (28.57) | 18.7374 |
| 1990's | 7 (25.00) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 2 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aghamohammadi, A | 1 |
| Akrami, SM | 1 |
| Yaghmaie, M | 1 |
| Rezaei, N | 1 |
| Azizi, G | 1 |
| Yaseri, M | 1 |
| Nosrati, H | 1 |
| Zaki-Dizaji, M | 1 |
| Claes, K | 1 |
| Depuydt, J | 1 |
| Taylor, AM | 1 |
| Last, JI | 1 |
| Baert, A | 1 |
| Schietecatte, P | 1 |
| Vandersickel, V | 1 |
| Poppe, B | 1 |
| De Leeneer, K | 1 |
| D'Hooghe, M | 1 |
| Vral, A | 1 |
| Marcelain, K | 1 |
| Navarrete, CL | 1 |
| Bravo, M | 2 |
| Santos, M | 1 |
| Be, C | 1 |
| Pincheira, J | 2 |
| Goodarzi, AA | 1 |
| Lees-Miller, SP | 1 |
| Terzoudi, GI | 1 |
| Manola, KN | 1 |
| Pantelias, GE | 1 |
| Iliakis, G | 2 |
| Mladenov, E | 1 |
| Tsaneva, I | 1 |
| Anachkova, B | 1 |
| Rahal, EA | 1 |
| Henricksen, LA | 1 |
| Li, Y | 1 |
| Turchi, JJ | 1 |
| Pawelczak, KS | 1 |
| Dixon, K | 1 |
| Boorstein, R | 1 |
| Campisi, J | 1 |
| Pardee, AB | 1 |
| Natarajan, AT | 3 |
| Obe, G | 1 |
| Dulout, FN | 1 |
| Hansson, K | 1 |
| Kihlman, BA | 1 |
| Furcinitti, PS | 1 |
| Painter, RB | 1 |
| Meijers, M | 1 |
| van Zeeland, AA | 1 |
| Simons, JW | 1 |
| Murnane, JP | 2 |
| Schwartz, JL | 1 |
| Bebb, DG | 1 |
| Steele, PP | 1 |
| Warrington, PJ | 1 |
| Moffat, JA | 1 |
| Glickman, BW | 1 |
| Shackelford, RE | 1 |
| Kaufmann, WK | 1 |
| Paules, RS | 1 |
| Zhou, BB | 1 |
| Chaturvedi, P | 1 |
| Spring, K | 1 |
| Scott, SP | 1 |
| Johanson, RA | 1 |
| Mishra, R | 1 |
| Mattern, MR | 1 |
| Winkler, JD | 1 |
| Khanna, KK | 1 |
| Asaad, NA | 1 |
| Zeng, ZC | 1 |
| Guan, J | 1 |
| Thacker, J | 1 |
| Speit, G | 1 |
| Trenz, K | 1 |
| Schütz, P | 1 |
| Bendix, R | 1 |
| Dörk, T | 1 |
| Feijoo, C | 1 |
| Hall-Jackson, C | 1 |
| Wu, R | 1 |
| Jenkins, D | 1 |
| Leitch, J | 1 |
| Gilbert, DM | 1 |
| Smythe, C | 1 |
| Sarkaria, JN | 1 |
| Eshleman, JS | 1 |
| Guo, N | 1 |
| Faller, DV | 1 |
| Vaziri, C | 1 |
| Pawlak, AL | 2 |
| Kotecki, M | 1 |
| Ignatowicz, R | 2 |
| Bates, PR | 1 |
| Imray, FP | 1 |
| Lavin, MF | 1 |
| Zampetti-Bosseler, F | 1 |
| Scott, D | 1 |
3 reviews available for caffeine and Ataxia Telangiectasia Syndrome
| Article | Year |
|---|---|
Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective.
Topics: Animals; Apoptosis; Ataxia Telangiectasia; Caffeine; Cell Cycle; Cell Cycle Proteins; DNA Damage; DN | 1995 |
Cell cycle control, checkpoint mechanisms, and genotoxic stress.
Topics: Animals; Ataxia Telangiectasia; Caffeine; Cell Cycle; Cyclins; DNA Repair; Genes, p53; Humans; Neopl | 1999 |
ATM as a target for novel radiosensitizers.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle; Cell Cycle Prot | 2001 |
25 other studies available for caffeine and Ataxia Telangiectasia Syndrome
| Article | Year |
|---|---|
Individual Radiosensitivity Assessment of the Families of
Topics: Adolescent; Adult; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Atherosclerosis; C | 2018 |
Variant ataxia telangiectasia: clinical and molecular findings and evaluation of radiosensitive phenotypes in a patient and relatives.
Topics: Adult; Amino Acid Substitution; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Breas | 2013 |
[Effect of vitamin E (DL-alpha-tocopherol) on the frequency of chromosomal damage in lymphocytes from patients with ataxia telangiectasia].
Topics: alpha-Tocopherol; Ataxia Telangiectasia; Caffeine; Case-Control Studies; Child; Chromosome Aberratio | 2002 |
Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells.
Topics: Amino Acid Sequence; Androstadienes; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; | 2004 |
Checkpoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells.
Topics: Ataxia Telangiectasia; Caffeine; Central Nervous System Stimulants; Chromatin Assembly and Disassemb | 2005 |
Activation of the S phase DNA damage checkpoint by mitomycin C.
Topics: Androstadienes; Antibiotics, Antineoplastic; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Pr | 2007 |
ATM mediates repression of DNA end-degradation in an ATP-dependent manner.
Topics: Adenosine Triphosphate; Androstadienes; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Protein | 2008 |
The study of DNA-repair defects using [125I]iododeoxycytidine incorporation as an assay for the growth of herpes simplex virus.
Topics: Ataxia Telangiectasia; Bloom Syndrome; Bromodeoxycytidine; Caffeine; Cell Cycle; Cells, Cultured; De | 1983 |
The effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro.
Topics: Adult; Ataxia Telangiectasia; Caffeine; Chromosome Aberrations; Down Syndrome; Female; Humans; In Vi | 1980 |
Effect of caffeine in G2 on X-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells.
Topics: Ataxia Telangiectasia; Caffeine; Cells, Cultured; Chromosome Aberrations; Chromosomes; DNA Repair; F | 1984 |
The potentiation by caffeine of X-ray damage to cultured human skin fibroblasts from normal subjects and ataxia-telangiectasia patients.
Topics: Ataxia Telangiectasia; Caffeine; Cell Survival; Dose-Response Relationship, Radiation; Fibroblasts; | 1983 |
Structural changes in chromatin as the basis for radiosensitivity in ataxia telangiectasia.
Topics: Ataxia Telangiectasia; Caffeine; Cell Line; Chromatin; Chromosome Aberrations; DNA; DNA Repair; Huma | 1982 |
Attempts to detect ataxia telangiectasia (AT) heterozygotes by cytogenetical techniques.
Topics: Adult; Ataxia Telangiectasia; Caffeine; Cell Line; Cell Nucleus; Cell Survival; Chromosome Aberratio | 1982 |
Cell checkpoint and radiosensitivity.
Topics: Ataxia Telangiectasia; Caffeine; Cell Cycle; DNA Damage; G1 Phase; Humans; Radiation Tolerance; Tumo | 1993 |
Caffeine does not potentiate gamma-radiation induced DNA damage in ataxia telangiectasia lymphoblastoid cells.
Topics: Ataxia Telangiectasia; Caffeine; Cell Line; DNA; DNA Damage; DNA Repair; Female; Gamma Rays; Heteroz | 1998 |
Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Caffeine; cdc25 Phosphatases; Cell Cy | 2000 |
Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants.
Topics: Animals; Ataxia Telangiectasia; Caffeine; CHO Cells; Cricetinae; DNA; DNA Damage; DNA Repair; DNA-Bi | 2000 |
Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation in comparison to ataxia telangiectasia heterozygote cells.
Topics: Ataxia Telangiectasia; Caffeine; Comet Assay; DNA Damage; DNA Repair; Female; Gamma Rays; Genes, BRC | 2000 |
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing.
Topics: Alkaloids; Animals; Aphidicolin; Ataxia Telangiectasia; Caffeine; Cell Fractionation; Cell Line; Cel | 2001 |
Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenoviridae; Alkaloids; Antineoplastic Agents; | 2002 |
[Ataxia telangiectasia: effects of cycloheximide on G2 repair of chromosome damage in lymphocytes cultured in vitro].
Topics: Ataxia Telangiectasia; Caffeine; Chromosome Aberrations; Cycloheximide; DNA Repair; Humans; In Vitro | 1992 |
Increased frequency of chromatid breaks in lymphocytes of heterozygotes of ataxia telangiectasia after in vitro treatment with caffeine.
Topics: Ataxia Telangiectasia; Caffeine; Cells, Cultured; Chromatids; Chromosome Aberrations; Heterozygote; | 1990 |
Cytogenetic and biochemical studies in homo- and heterozygotes of ataxia-telangiectasia. Interaction between in vivo and in vitro exposure.
Topics: Ataxia Telangiectasia; Benzo(a)pyrene; Caffeine; Cell Division; Cells, Cultured; Chromosome Aberrati | 1990 |
Effect of caffeine on gamma-ray-induced G2 delay in ataxia telangiectasia.
Topics: Ataxia Telangiectasia; Caffeine; Cell Line; Chromosome Aberrations; Cobalt Radioisotopes; DNA; Flow | 1985 |
The effect of caffeine on X-ray-induced mitotic delay in normal human and ataxia-telangiectasia fibroblasts.
Topics: Ataxia Telangiectasia; Caffeine; Cells, Cultured; Chromosome Aberrations; DNA Repair; Fibroblasts; H | 1985 |