caffeine and Aging studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

Excerpt	Relevance	Reference
" The presence of several bioactive compounds, such as polyphenols and caffeine, implicates coffee as a potential nutritional therapeutic in aging."	7.79	Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. ( Chu, YF; Joseph, JA; Lyle, BJ; Miller, MG; Shukitt-Hale, B, 2013)
"Our objective was to determine the prevalence and distribution of fasciculations in healthy adults and to assess the effect of age, caffeine and exercise."	7.76	Prevalence and distribution of fasciculations in healthy adults: Effect of age, caffeine consumption and exercise. ( Arts, IM; Fermont, J; Kleine, BU; Overeem, S; Schelhaas, HJ; Zwarts, MJ, 2010)
" The potency (pD2 value) of phenylephrine increased with age from 3 to 10 weeks, but decreased thereafter from 10 to 80 weeks, while the affinity (pKA value) of phenylephrine to alpha 1-adrenoceptors did not alter with aging."	7.68	Contractile responses of rat aorta to phenylephrine and serotonin, and aging. ( Ohtsuki, H; Onozuka, S; Shinkai, M; Takayanagi, I, 1991)
"Caffeine was used to manipulate the energetic state of the subjects."	6.68	Aging, caffeine, and information processing: an event-related potential analysis. ( Kok, A; Lorist, MM; Mulder, G; Snel, J, 1995)
"Caffeine was administrated during all prenatal and postnatal life (CAF, 0."	5.51	Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence. ( Abreu-Villaça, Y; da Silva Gonçalves, B; Filgueiras, CC; Leal-Rocha, PH; Manhães, AC; Ribeiro-Carvalho, A, 2019)
" The mean hepatic clearances determined by in silico fitting for individual pharmacokinetic models of warfarin and midazolam in the aged group were, respectively, 23% and 56% smaller than those for the young group."	5.48	Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. ( Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H, 2018)
"Caffeine is a commonly used psychoactive substance and consumption by children and adolescents continues to rise."	5.43	Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling. ( Archuleta, S; Bachtell, RK; Campeau, S; Levis, SC; Newsom, RJ; O'Neill, CE; Scott, T; Spencer, RL; Stafford, J, 2016)
"d-galactose has been considered a senescent model for age-related neurodegenerative disease."	5.42	Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. ( Ali, T; Kim, MO; Ullah, F; Ullah, N, 2015)
"Insulin sensitivity was assessed by means of the insulin tolerance test."	5.39	Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity. ( Conde, SV; Guarino, MP; Ribeiro, MJ; Sacramento, JF, 2013)
"Chronic neuroinflammation is associated with an increase in extracellular levels of glutamate and drugs that limit the effects of glutamate at neuronal receptors have been shown to indirectly reduce the neuroinflammatory response of microglia cells."	5.36	Caffeine attenuates lipopolysaccharide-induced neuroinflammation. ( Brothers, HM; Marchalant, Y; Wenk, GL, 2010)
"Caffeine half-life was greatly increased in two infants who had cholestatic hepatitis secondary to prolonged parenteral alimentation and one infant who was breast-fed exclusively."	5.27	Maturational changes of caffeine concentrations and disposition in infancy during maintenance therapy for apnea of prematurity: influence of gestational age, hepatic disease, and breast-feeding. ( Billon, B; Le Guennec, JC; Paré, C, 1985)
"High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e."	4.91	The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. ( Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP, 2015)
"The most common source of dietary caffeine among the elderly is coffee, with consumption averaging about 200 mg/day."	4.80	Caffeine and the elderly. ( Massey, LK, 1998)
" The presence of several bioactive compounds, such as polyphenols and caffeine, implicates coffee as a potential nutritional therapeutic in aging."	3.79	Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. ( Chu, YF; Joseph, JA; Lyle, BJ; Miller, MG; Shukitt-Hale, B, 2013)
"We measured the duration of apnea induced by sustained end-inspiratory lung inflation (the Hering Breuer Reflex, HBR) in unanesthetized infant rat pups aged 4 days (P4) to P20 at body temperatures of 32°C and 36°C."	3.79	Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups. ( Arnal, AV; Bartlett, D; Gore, JL; Leiter, JC; Rudkin, A, 2013)
"Beneficial effects of caffeine on memory processes have been observed in animal models relevant to neurodegenerative diseases and aging, although the underlying mechanisms remain unknown."	3.79	Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. ( Ardais, AP; Botton, PH; Costa, MS; Elisabetsky, E; Fioreze, GT; Forte, T; Klaudat, B; Nunes, F; Porciúncula, LO; Sallaberry, C; Souza, DO, 2013)
" However, the aging-related phenomenon could be prevented by caffeine treatment."	3.78	Oxidative phosphorylation-linked respiration in individual bovine oocytes. ( Aikawa, Y; Hashiyada, Y; Imai, K; Kobayashi, S; Konishi, K; Matoba, S; Matsuda, H; Ohtake, M; Sugimura, S, 2012)
"In this study, the effects of caffeine (CAF) and SCH58261, a selective A(2A) receptor antagonist, on memory impairment and oxidative stress generated by aging in rats were investigated."	3.77	Protective effect of caffeine and a selective A2A receptor antagonist on impairment of memory and oxidative stress of aged rats. ( Brandão, R; Jesse, CR; Leite, MR; Nogueira, CW; Wilhelm, EA, 2011)
"Our objective was to determine the prevalence and distribution of fasciculations in healthy adults and to assess the effect of age, caffeine and exercise."	3.76	Prevalence and distribution of fasciculations in healthy adults: Effect of age, caffeine consumption and exercise. ( Arts, IM; Fermont, J; Kleine, BU; Overeem, S; Schelhaas, HJ; Zwarts, MJ, 2010)
"Caffeine, a non-selective adenosine receptor antagonist, has been suggested as a potential drug to counteract age-related cognitive decline since critical changes in adenosinergic neurotransmission occur with aging."	3.73	Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors. ( Batista, LC; Prediger, RD; Takahashi, RN, 2005)
"Early developmental exposure to caffeine in rats results in decreased susceptibility to certain chemically-induced seizures in the adult."	3.69	Neonatal caffeine exposure alters seizure susceptibility in rats in an age-related manner. ( Guillet, R, 1995)
"Pregnant Yorkshire gilts (n = 42) were fed caffeine (6 g/d) or served as controls from d 60 of pregnancy until d 4 postpartum to test the effect of caffeine on mammary gland development, milk yield, and feed consumption."	3.69	The effect of caffeine on mammary gland development and milk yield in primiparous sows. ( Hacker, RR; Li, S, 1995)
" The potency (pD2 value) of phenylephrine increased with age from 3 to 10 weeks, but decreased thereafter from 10 to 80 weeks, while the affinity (pKA value) of phenylephrine to alpha 1-adrenoceptors did not alter with aging."	3.68	Contractile responses of rat aorta to phenylephrine and serotonin, and aging. ( Ohtsuki, H; Onozuka, S; Shinkai, M; Takayanagi, I, 1991)
"Five neonates (4 premature) and 16 infants (6 prematurely born), 15-588 days old, received caffeine as citrate salt for apnea."	3.67	Developmental changes of caffeine elimination in infancy. ( Badoual, J; Carrier, O; d'Athis, P; Moran, C; Olive, G; Pons, G; Rey, E; Richard, MO, 1988)
"Caffeine intake was related to moderately better cognitive maintenance over 5 years in older women with vascular disorders."	2.78	Caffeine and cognitive decline in elderly women at high vascular risk. ( Berr, C; Kang, JH; Ritchie, K; Vercambre, MN, 2013)
" 230 l), and the half-life was slightly increased (19."	2.68	Influence of age, frailty and liver function on the pharmacokinetics of brofaromine. ( Antonin, KH; Bergmann, W; Bieck, P; Degel, F; Fuchs, L; Platt, D; Zeeh, J, 1996)
" Urine samples were collected for 24 h after dosing and analysed for caffeine and eleven of its metabolites by high-performance liquid chromatography."	2.66	Comparison of the urinary metabolite profile of caffeine in young and elderly males. ( Blanchard, J; Jonkman, JH; Sawers, SJ; Tang-Liu, DD, 1985)
" While coffee and caffeine are known to enhance short-term memory and cognition, some limited research also suggests that long-term use may protect against cognitive decline or dementia."	2.50	Current evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer's disease. ( Carman, AJ; Dacks, PA; Fillit, HM; Lane, RF; Shineman, DW, 2014)
"Caffeine is a widely consumed psychoactive drug, which is emerging as a protective agent against AD progression and in aging associated deficits."	2.47	Modulating Alzheimer's disease through caffeine: a putative link to epigenetics. ( Batalha, VL; Lopes, LV; Marques, S; Outeiro, TF, 2011)
"While acute orthostatic hypotension is usually secondary to medication, fluid or blood loss, or adrenal insufficiency, chronic orthostatic hypotension is frequently due to altered blood pressure regulatory mechanisms and autonomic dysfunction."	2.44	Orthostatic hypotension in the elderly: diagnosis and treatment. ( Gupta, V; Lipsitz, LA, 2007)
"Children's risks can differ from those in adults for numerous reasons, one being differences in the pharmacokinetic handling of chemicals."	2.42	Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents. ( Ginsberg, G; Hattis, D; Russ, A; Sonawane, B, 2004)
"26."	1.72	Sleep Disorders and Future Diagnosis of Parkinsonism: A Prospective Study Using the Canadian Longitudinal Study on Aging. ( Pelletier, A; Postuma, RB; Wolfson, C; Yao, CW; Zolfaghari, S, 2022)
"Caffeine was administrated during all prenatal and postnatal life (CAF, 0."	1.51	Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence. ( Abreu-Villaça, Y; da Silva Gonçalves, B; Filgueiras, CC; Leal-Rocha, PH; Manhães, AC; Ribeiro-Carvalho, A, 2019)
"Caffeine is a bioactive compound worldwide consumed with effect into the brain."	1.51	Caffeine Neuroprotection Decreases A2A Adenosine Receptor Content in Aged Mice. ( Alves, MC; Boeck, CR; Damiani, AP; de Abreu, LL; de Andrade, VM; Garcez, ML; Pacheco, R; Rodrigues, L, 2019)
" The mean hepatic clearances determined by in silico fitting for individual pharmacokinetic models of warfarin and midazolam in the aged group were, respectively, 23% and 56% smaller than those for the young group."	1.48	Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. ( Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H, 2018)
"Caffeine is a well-established performance enhancing nutritional supplement in a young healthy population, however far less is known about how its ergogenicity is affected by increasing age."	1.46	Is the Ergogenicity of Caffeine Affected by Increasing Age? The Direct Effect of a Physiological Concentration of Caffeine on the Power Output of Maximally Stimulated EDL and Diaphragm Muscle Isolated from the Mouse. ( Cox, VM; Duncan, MJ; James, RS; Tallis, J, 2017)
"Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body."	1.46	Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice. ( Baba, H; Morimoto, Y; Ogawa, H; Takahashi, T; Tsunematsu, T; Tsuneyama, K; Uehara, H; Watanabe, S, 2017)
"Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear."	1.46	Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. ( Blanco, P; Bolen, CR; Chang, J; Daburon, S; Davis, MM; Déchanet-Merville, J; Dekker, CL; Douchet, I; Faustin, B; Fragiadakis, GK; Furman, D; Ganio, EA; Gaudilliere, B; Haddad, F; Jojic, V; Kuo, CJ; Lartigue, L; Moreau, JF; Nolan, GP; Spitzer, MH, 2017)
"Caffeine is a commonly used psychoactive substance and consumption by children and adolescents continues to rise."	1.43	Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling. ( Archuleta, S; Bachtell, RK; Campeau, S; Levis, SC; Newsom, RJ; O'Neill, CE; Scott, T; Spencer, RL; Stafford, J, 2016)
"d-galactose has been considered a senescent model for age-related neurodegenerative disease."	1.42	Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. ( Ali, T; Kim, MO; Ullah, F; Ullah, N, 2015)
"Caffeine has been reported to produce many beneficial effects for health."	1.40	Moderate swimming exercise and caffeine supplementation reduce the levels of inflammatory cytokines without causing oxidative stress in tissues of middle-aged rats. ( Bresciani, G; Carvalho, NR; Cechella, JL; da Rocha, JT; Dobrachinski, F; Duarte, MM; Leite, MR; Royes, LF; Soares, FA; Zeni, G, 2014)
"Insulin sensitivity was assessed by means of the insulin tolerance test."	1.39	Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity. ( Conde, SV; Guarino, MP; Ribeiro, MJ; Sacramento, JF, 2013)
"Predicted metabolic drug clearances (CLPT ) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®."	1.39	Predicted metabolic drug clearance with increasing adult age. ( Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD, 2013)
"Caffeine treatment at a daily dose of 10 and/or 20 mg/kg, sc was executed during postnatal days 7-11."	1.39	Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood. ( Kubová, H; Mareš, P; Tchekalarova, JD, 2013)
"Caffeine treatment (5 mg/kg/day) began when animals were ≈4 months old, and lasted for 6 months."	1.38	Chronic caffeine consumption prevents cognitive decline from young to middle age in rats, and is associated with increased length, branching, and spine density of basal dendrites in CA1 hippocampal neurons. ( Alvarez-Cervera, FJ; Arankowsky-Sandoval, G; Bata-García, JL; Cabrera-Isidoro, S; Flores, G; Góngora-Alfaro, JL; Heredia-López, F; Juárez-Díaz, I; Vila-Luna, L; Vila-Luna, S; Zapata-Vázquez, RE, 2012)
"Chronic neuroinflammation is associated with an increase in extracellular levels of glutamate and drugs that limit the effects of glutamate at neuronal receptors have been shown to indirectly reduce the neuroinflammatory response of microglia cells."	1.36	Caffeine attenuates lipopolysaccharide-induced neuroinflammation. ( Brothers, HM; Marchalant, Y; Wenk, GL, 2010)
"The prevalence of osteoporosis and osteopenia were 8."	1.36	Risk factors of osteoporosis in healthy Moroccan men. ( Dehhaoui, M; El Maghraoui, A; Gassim, S; Ghazi, M; Ghozlani, I; Mounach, A; Rezqi, A, 2010)
"Caffeine was then rapidly applied for 5 s at defined intervals from 60 to 300 s."	1.33	Advancing age alters rapid and spontaneous refilling of caffeine-sensitive calcium stores in sympathetic superior cervical ganglion cells. ( Buchholz, JN; Pearce, WJ; Vanterpool, CK, 2005)
"Excessive daytime sleepiness may be associated with an increased risk of developing Parkinson disease."	1.33	Excessive daytime sleepiness and subsequent development of Parkinson disease. ( Abbott, RD; Curb, JD; Masaki, KH; Nelson, JS; Petrovitch, H; Ross, GW; Tanner, CM; White, LR, 2005)
"The ryanodine-induced increase was due to influx of extracellular calcium because it was blocked by removal of extracellular calcium or by diltiazem."	1.31	Fetal rabbit pulmonary artery smooth muscle cell response to ryanodine is developmentally regulated. ( Cornfield, DN; Porter, VA; Reeve, HL, 2000)
"Caffeine is a substance which many people consume in their daily life."	1.30	Effects of caffeine on the bones of aged, ovariectomized rats. ( Cheuk, G; Falster, AU; Kamagata-Kiyoura, Y; Nakamoto, T; Ohta, M; Simmons, WB; Thomas, KA; Wink, CS; Yazdani, M, 1999)
"The caffeine effects were more pronounced in adult than in newborn fibres while the cyclopiazonic acid effects were larger in newborn preparations."	1.29	Effects of caffeine and cyclopiazonic acid on contractile proteins of adult and newborn ferret cardiac fibres. ( Bonnet, V; Léoty, C, 1996)
"1."	1.29	Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults. ( Cazeneuve, C; Cresteil, T; D'Athis, P; Olive, G; Pons, G; Rey, E; Thiroux, G; Treluyer, JM, 1994)
"Caffeine intake was inversely associated with age and waist/hip ratio and positively associated with alcohol consumption."	1.29	Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. ( Barrett-Connor, E; Ferrini, RL, 1996)
"Caffeine consumption was reliably associated with the self-reported occurrence of somatic symptoms, but not psychological well-being."	1.28	Self-report reliability and symptomatology of habitual caffeine consumption. ( Bruce, MS; James, JE; Lader, MH; Scott, NR, 1989)
"Caffeine treatment (100 mg/kg for 3 days) increased relative liver weight in female guinea-pigs and decreased it in chicks and female mice, and decreased microsomal protein content in male mice, female guinea-pigs and young rats, and increased it in chicks."	1.27	In vivo and in vitro effects of caffeine on hepatic mixed-function oxidases in rodents and chicks. ( Govindwar, SP; Kachole, MS; Pawar, SS, 1984)
" This finding suggests that the intestinal absorption of calcium was stimulated by the increase in 1,25(OH)2D production after chronic administration of caffeine."	1.27	Differential effect of caffeine administration on calcium and vitamin D metabolism in young and adult rats. ( Aloia, JF; Yeh, JK, 1986)
"Caffeine was extracted from diluted serum and saliva samples (10-500 microliter) by adsorption on a small Bond-Elut C18 cartridge and recovered by elution with methanol."	1.27	Rapid high-performance liquid chromatography assay for salivary and serum caffeine following an oral load. An indicator of liver function. ( Balistreri, WF; Klooster, MJ; Lim, CK; Setchell, KD; Welsh, MB, 1987)
"Caffeine half-life was greatly increased in two infants who had cholestatic hepatitis secondary to prolonged parenteral alimentation and one infant who was breast-fed exclusively."	1.27	Maturational changes of caffeine concentrations and disposition in infancy during maintenance therapy for apnea of prematurity: influence of gestational age, hepatic disease, and breast-feeding. ( Billon, B; Le Guennec, JC; Paré, C, 1985)
"Caffeine was also analyzed in tissues of newborn and adult dogs 3, 10, and 36 hr after single doses of caffeine (50 mg/kg IV)."	1.26	Tissue distribution of caffeine in premature infants and in newborn and adult dogs. ( Gorodischer, R; Warszawski, D, 1981)
" Rat pups were given either aminophylline, theophylline, or caffeine in a dosage of 40 mg/kg or 80 mg/kg daily from the second postnatal day through 20 days of age."	1.26	A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain. ( Fuller, GN; Wiggins, RC, 1981)
"The dose-response relationships for three stimulants have been explored."	1.25	The effects of age and illumination on the dose-response curves for three stimulants. ( Isaac, W; Kallman, WM, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	64 (29.77)	18.7374
1990's	46 (21.40)	18.2507
2000's	44 (20.47)	29.6817
2010's	57 (26.51)	24.3611
2020's	4 (1.86)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Pilot, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Effectiveness and Safety of an Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health Among [NCT05170113]		79 participants (Actual)	Interventional	2021-11-02	Completed
A Pilot Study of Facial Recognition Software to Assess Palatability in Pediatric Patients[NCT02923908]		12 participants (Actual)	Observational	2016-12-31	Completed
Efficacy of Bitter Taste Blockers on Flavor Acceptance in Pediatric Populations[NCT01407939]		215 participants (Actual)	Observational	2011-04-30	Completed
Comparison of Synthetic and Natural Caffeine on Hemodynamic Parameters in Young, Healthy Volunteers: A Randomized, Double Blind, Crossover Study[NCT03495063]		0 participants (Actual)	Interventional	2019-09-16	Withdrawn (stopped due to Unable to quantify caffeine)
Residual Immune Activation in HIV-infected Patients on Successful cART: Association Between Inflammasome Activation in Monocytes by Circulating Metabolites and Non AIDS Defining Comorbidities[NCT03191175]		55 participants (Actual)	Observational	2017-07-03	Completed
Immune Senescence in the Elderly: Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages[NCT01827462]	Phase 4	136 participants (Actual)	Interventional	2007-10-31	Completed
Longitudinal Study to Assess the Effects of Whole Coffee Cherry Extract (WCCE)[NCT04986956]		323 participants (Actual)	Interventional	2022-02-01	Active, not recruiting
Effects of Insulin on Hypotension and Sarcopenia[NCT03248271]		0 participants (Actual)	Observational	2017-10-01	Withdrawn (stopped due to Study design was changed to the study was changed to Insulin, hypotension and sarcopenia.)
Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia[NCT05295784]	Phase 1	18 participants (Anticipated)	Interventional	2024-06-30	Not yet recruiting
CID 0708 - Sex, Aging and Antiretroviral Pharmacokinetics[NCT00666055]		11 participants (Actual)	Observational	2008-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	Participants (Count of Participants)
18-30 Years Old at Enrollment	59
60-79 Years Old at Enrollment	37
80-100 Years Old at Enrollment	40

Article	Year
Effect of Supplements on Endurance Exercise in the Older Population: Systematic Review. International journal of environmental research and public health, 2020, 07-20, Volume: 17, Issue:14 Topics: Aged; Aging; Caffeine; Dietary Supplements; Exercise; Exercise Therapy; Female; Humans; Male; Physic	2020
Caffeine intake and its sources: A review of national representative studies. Critical reviews in food science and nutrition, 2018, May-24, Volume: 58, Issue:8 Topics: Aging; Beverages; Caffeine; Global Health; Humans	2018
Current evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer's disease. The journal of nutrition, health & aging, 2014, Volume: 18, Issue:4 Topics: Aging; Alzheimer Disease; Animals; Caffeine; Coffee; Cognition; Cognition Disorders; Humans; Memory,	2014
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. Current topics in medicinal chemistry, 2015, Volume: 15, Issue:21 Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobrom	2015
Optimizing natural fertility. Fertility and sterility, 2008, Volume: 90, Issue:5 Suppl Topics: Aging; Alcohol Drinking; Caffeine; Coitus; Diet; Female; Fertility; Humans; Life Style; Male; Ovulat	2008
Sleep: a good investment in health and safety. Journal of agromedicine, 2008, Volume: 13, Issue:2 Topics: Age Factors; Aged; Aging; Agriculture; Caffeine; Central Nervous System Stimulants; Fatigue; Female;	2008
Modulating Alzheimer's disease through caffeine: a putative link to epigenetics. Journal of Alzheimer's disease : JAD, 2011, Volume: 24 Suppl 2 Topics: Adenosine A2 Receptor Antagonists; Aging; Alzheimer Disease; Animals; Caffeine; Epigenesis, Genetic;	2011
Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents. Journal of toxicology and environmental health. Part A, 2004, Feb-27, Volume: 67, Issue:4 Topics: Adult; Aging; Caffeine; Environmental Exposure; Half-Life; Humans; Infant, Newborn; Liver; Metabolic	2004
Attention, psychomotor functions and age. European journal of nutrition, 2005, Volume: 44, Issue:8 Topics: Aged; Aging; Attention; Caffeine; Cognition; Glucose; Humans; Memory; Mental Processes; Middle Aged;	2005
Orthostatic hypotension in the elderly: diagnosis and treatment. The American journal of medicine, 2007, Volume: 120, Issue:10 Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents; Blood Pressure	2007
Theophylline reassessed. Annals of internal medicine, 1984, Volume: 101, Issue:1 Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents;	1984
Age-dependent changes in calcium currents and calcium homeostasis in mammalian neurons. Annals of the New York Academy of Sciences, 1994, Dec-15, Volume: 747 Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channels; Cells, Cultured; Cerebral Cor	1994
Caffeine and the elderly. Drugs & aging, 1998, Volume: 13, Issue:1 Topics: Aged; Aging; Bone and Bones; Caffeine; Cardiovascular System; Central Nervous System Stimulants; Die	1998
Nutrients, age and cognitive function. Current opinion in clinical nutrition and metabolic care, 1998, Volume: 1, Issue:6 Topics: Aged; Aging; Caffeine; Cognition; Diet; Dietary Supplements; Eating; Ginkgo biloba; Glucose; Humans;	1998
The science and complexity of bitter taste. Nutrition reviews, 2001, Volume: 59, Issue:6 Topics: Aging; Caffeine; Eating; Feeding Behavior; Flavoring Agents; Food Preferences; Humans; Perception; T	2001
The role of DNA repair and somatic mutation in carcinogenesis. Advances in cancer research, 1975, Volume: 21 Topics: Aging; Base Sequence; Caffeine; Carcinogens; Cell Differentiation; Cell Division; Chromatin; Chromos	1975
DNA repair. Essays in biochemistry, 1977, Volume: 13 Topics: Aging; Alkylating Agents; Animals; Caffeine; Carcinogens; Deoxyribodipyrimidine Photo-Lyase; DNA; DN	1977
[Recent progress in the pharmacology of learning and memory in China]. Yao xue xue bao = Acta pharmaceutica Sinica, 1986, Volume: 21, Issue:8 Topics: Aging; Caffeine; Learning; Memory; Panax; Plant Extracts; Plants, Medicinal	1986
Contracture and the calcium paradox. Journal of molecular and cellular cardiology, 1985, Volume: 17, Issue:8 Topics: 2,4-Dinitrophenol; Aging; Animals; Caffeine; Calcium; Dimethyl Sulfoxide; Dinitrophenols; Freeze Fra	1985
Drugs and memory disorders in human aging. Behavioral biology, 1972, Volume: 7, Issue:5 Topics: Adolescent; Adult; Aged; Aging; Amphetamine; Anticonvulsants; Antidepressive Agents; Arousal; Caffei	1972

Article	Year
Caffeine and cognitive decline in elderly women at high vascular risk. Journal of Alzheimer's disease : JAD, 2013, Volume: 35, Issue:2 Topics: Aged; Aging; Caffeine; Central Nervous System Stimulants; Cerebrovascular Disorders; Cognition; Cogn	2013
Age-related differences in bitter taste and efficacy of bitter blockers. PloS one, 2014, Volume: 9, Issue:7 Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt	2014
Age-related differences in bitter taste and efficacy of bitter blockers. PloS one, 2014, Volume: 9, Issue:7 Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt	2014
Age-related differences in bitter taste and efficacy of bitter blockers. PloS one, 2014, Volume: 9, Issue:7 Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt	2014
Age-related differences in bitter taste and efficacy of bitter blockers. PloS one, 2014, Volume: 9, Issue:7 Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt	2014
Caffeine intake increases plasma ketones: an acute metabolic study in humans. Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:4 Topics: Adult; Aging; Alzheimer Disease; Brain; Caffeine; Dietary Supplements; Dose-Response Relationship, D	2017
Caffeine impairs myocardial blood flow response to physical exercise in patients with coronary artery disease as well as in age-matched controls. PloS one, 2009, May-22, Volume: 4, Issue:5 Topics: Aging; Caffeine; Case-Control Studies; Coronary Artery Disease; Coronary Circulation; Exercise; Fema	2009
The effect of caffeine on working memory load-related brain activation in middle-aged males. Neuropharmacology, 2013, Volume: 64 Topics: Adult; Aging; Attention; Caffeine; Central Nervous System Stimulants; Coffee; Cross-Over Studies; Do	2013
Challenging sleep in aging: the effects of 200 mg of caffeine during the evening in young and middle-aged moderate caffeine consumers. Journal of sleep research, 2006, Volume: 15, Issue:2 Topics: Adult; Aged; Aging; Beverages; Caffeine; Circadian Rhythm; Coffee; Cross-Over Studies; Double-Blind	2006
Aging, caffeine, and information processing: an event-related potential analysis. Electroencephalography and clinical neurophysiology, 1995, Volume: 96, Issue:5 Topics: Adolescent; Adult; Aged; Aging; Caffeine; Electroencephalography; Evoked Potentials, Auditory; Femal	1995
Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men. The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 1 Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Body Temperature; Caffeine; Carbon Radioisotop	1995
Interactions between dietary caffeine and calcium on calcium and bone metabolism in older women. Journal of the American College of Nutrition, 1994, Volume: 13, Issue:6 Topics: Adult; Aged; Aging; Alkaline Phosphatase; Bone and Bones; Caffeine; Calcium; Calcium, Dietary; Creat	1994
Acute effects of fructose and glucose ingestion with and without caffeine in young and old humans. Metabolism: clinical and experimental, 1995, Volume: 44, Issue:5 Topics: Adult; Aged; Aging; Alanine; Analysis of Variance; Blood Glucose; Body Temperature Regulation; Caffe	1995
Influence of age, frailty and liver function on the pharmacokinetics of brofaromine. European journal of clinical pharmacology, 1996, Volume: 49, Issue:5 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Caffeine; Chromatography, Gas; Cross-Ov	1996
Relationship of blood pressure, heart rate and behavioral mood state to norepinephrine kinetics in younger and older men following caffeine ingestion. European journal of clinical nutrition, 1998, Volume: 52, Issue:11 Topics: Adult; Affect; Aged; Aging; Blood Pressure; Body Composition; Caffeine; Double-Blind Method; Heart R	1998
The effects of age on the response to caffeine. Psychopharmacology, 1988, Volume: 94, Issue:1 Topics: Adolescent; Adult; Aged; Aging; Attention; Caffeine; Female; Flicker Fusion; Humans; Male; Postural	1988
Comparison of the urinary metabolite profile of caffeine in young and elderly males. British journal of clinical pharmacology, 1985, Volume: 19, Issue:2 Topics: Adult; Aged; Aging; Caffeine; Glomerular Filtration Rate; Humans; Male; Random Allocation; Theobromi	1985
Effect of maternal caffeine consumption on heart rate and sleep time of breast-fed infants. Developmental pharmacology and therapeutics, 1985, Volume: 8, Issue:6 Topics: Aging; Breast Feeding; Caffeine; Double-Blind Method; Female; Heart Rate; Humans; Infant; Infant, Ne	1985

caffeine and Aging

Research Excerpts

Research

Studies (215)

Authors

Clinical Trials (10)

Trial Overview

Trial Outcomes

Number of Participants Who Received the Influenza Vaccine

Reviews

Trials

Other Studies

Authors	Studies
Zolfaghari, S	1
Yao, CW	1
Wolfson, C	1
Pelletier, A	1
Postuma, RB	1
Romero, MA	1
Mumford, PW	1
Roberson, PA	1
Osburn, SC	1
Parry, HA	1
Kavazis, AN	1
Gladden, LB	1
Schwartz, TS	1
Baker, BA	1
Toedebusch, RG	1
Childs, TE	1
Booth, FW	1
Roberts, MD	1
França, AP	1
Schamne, MG	1
de Souza, BS	1
da Luz Scheffer, D	1
Bernardelli, AK	1
Corrêa, T	1
de Souza Izídio, G	1
Latini, A	1
da Silva-Santos, JE	1
Canas, PM	1
Cunha, RA	2
Prediger, RD	2
Martínez-Rodríguez, A	1
Cuestas-Calero, BJ	1
Hernández-García, M	1
Martíez-Olcina, M	1
Vicente-Martínez, M	1
Rubio-Arias, JÁ	1
Min, H	1
Youn, E	1
Shim, YH	1
Tallis, J	1
James, RS	1
Cox, VM	1
Duncan, MJ	1
Watanabe, S	1
Takahashi, T	1
Ogawa, H	1
Uehara, H	1
Tsunematsu, T	1
Baba, H	1
Morimoto, Y	1
Tsuneyama, K	1
Takahashi, K	2
Yanai, S	1
Shimokado, K	1
Ishigami, A	2
Verster, JC	1
Koenig, J	1
Toda, A	1
Uehara, S	1
Inoue, T	1
Utoh, M	1
Kusama, T	1
Shimizu, M	1
Uno, Y	1
Mogi, M	1
Sasaki, E	1
Yamazaki, H	1
Bakris, GL	1
Orbán, C	1
Vásárhelyi, Z	1
Bajnok, A	1
Sava, F	1
Toldi, G	1
da Silva Gonçalves, B	1
Leal-Rocha, PH	1
Manhães, AC	1
Filgueiras, CC	1
Abreu-Villaça, Y	1
Ribeiro-Carvalho, A	1
Garcez, ML	1
Damiani, AP	1
Pacheco, R	1
Rodrigues, L	1
de Abreu, LL	1
Alves, MC	1
de Andrade, VM	1
Boeck, CR	1
Vercambre, MN	1
Berr, C	1
Ritchie, K	1
Kang, JH	2
Rallis, C	1
Bähler, J	1
Tchekalarova, J	2
Kubová, H	3
Mareš, P	3
Silva, CG	1
Métin, C	1
Fazeli, W	1
Machado, NJ	1
Darmopil, S	1
Launay, PS	1
Ghestem, A	1
Nesa, MP	1
Bassot, E	1
Szabó, E	1
Baqi, Y	2
Müller, CE	2
Tomé, AR	1
Ivanov, A	1
Isbrandt, D	1
Zilberter, Y	1
Esclapez, M	1
Bernard, C	1
Tchekalarova, JD	1
Cechella, JL	2
Leite, MR	4
Dobrachinski, F	2
da Rocha, JT	2
Carvalho, NR	1
Duarte, MM	1
Soares, FA	2
Bresciani, G	2
Royes, LF	2
Zeni, G	3
Marcondes Sari, MH	1
de Freitas, ML	1
Oliveira, LP	1
Dalmolin, L	1
Brandão, R	2
Carman, AJ	1
Dacks, PA	1
Lane, RF	1
Shineman, DW	1
Fillit, HM	1
Mennella, JA	1
Reed, DR	1
Roberts, KM	1
Mathew, PS	1
Mansfield, CJ	1
Gai, BM	1
Jiang, H	1
Wang, C	1
Guan, J	1
Wang, L	1
Li, Z	1
Lamboley, CR	1
Wyckelsma, VL	1
Dutka, TL	1
McKenna, MJ	1
Murphy, RM	1
Lamb, GD	1
Poole, RL	1
Braak, D	1
Gould, TJ	1
Cutler, RG	1
Camandola, S	1
Malott, KF	1
Edelhauser, MA	1
Mattson, MP	1
Ullah, F	1
Ali, T	1
Ullah, N	1
Kim, MO	1
Solfrizzi, V	1
Panza, F	1
Imbimbo, BP	1
D'Introno, A	1
Galluzzo, L	1
Gandin, C	1
Misciagna, G	1
Guerra, V	1
Osella, A	1
Baldereschi, M	1
Di Carlo, A	1
Inzitari, D	1
Seripa, D	1
Pilotto, A	1
Sabbá, C	1
Logroscino, G	1
Scafato, E	1
Frau, L	1
Costa, G	1
Porceddu, PF	1
Khairnar, A	1
Castelli, MP	1
Ennas, MG	1
Madeddu, C	1
Wardas, J	1
Morelli, M	1
Doty, RL	1
Heidt, JM	1
MacGillivray, MR	1
Dsouza, M	1
Tracey, EH	1
Mirza, N	1
Bigelow, D	1
O'Neill, CE	1
Newsom, RJ	1
Stafford, J	1
Scott, T	1
Archuleta, S	1
Levis, SC	1
Spencer, RL	1
Campeau, S	1
Bachtell, RK	1
Dance, A	1
Batalha, VL	2
Ferreira, DG	1
Coelho, JE	1
Valadas, JS	1
Gomes, R	1
Temido-Ferreira, M	1
Shmidt, T	1
Buée, L	1
Hamdane, M	1
Outeiro, TF	2
Bader, M	1
Meijsing, SH	1
Sadri-Vakili, G	1
Blum, D	1
Lopes, LV	2
Chauhan, G	1
Ray, K	1
Sahu, S	1
Roy, K	1
Jain, V	1
Wadhwa, M	1
Panjwani, U	1
Kishore, K	1
Singh, SB	1
Knapik, JJ	1
Trone, DW	1
McGraw, S	1
Steelman, RA	1
Austin, KG	1
Lieberman, HR	1
Furman, D	1
Chang, J	1
Lartigue, L	1
Bolen, CR	1
Haddad, F	1
Gaudilliere, B	1
Ganio, EA	1
Fragiadakis, GK	1
Spitzer, MH	1
Douchet, I	1
Daburon, S	1
Moreau, JF	1
Nolan, GP	1
Blanco, P	2
Déchanet-Merville, J	1
Dekker, CL	1
Jojic, V	1
Kuo, CJ	1
Davis, MM	1
Faustin, B	1
Vandenberghe, C	1
St-Pierre, V	1
Courchesne-Loyer, A	1
Hennebelle, M	1
Castellano, CA	1
Cunnane, SC	1
Unno, K	1
Yamamoto, H	1
Maeda, K	1
Takabayashi, F	1
Yoshida, H	1
Kikunaga, N	1
Takamori, N	1
Asahina, S	1
Iguchi, K	1
Sayama, K	1
Hoshino, M	1
Gregory, JM	1
Behringer, EJ	2
Vanterpool, CK	3
Pearce, WJ	3
Wilson, SM	3
Buchholz, JN	3
Lesk, VE	1
Honey, TE	1
de Jager, CA	1
Yuan, Q	1
Han, P	1
Dong, M	1
Ren, X	1
Zhou, X	1
Chen, S	1
Jones, WK	1
Chu, G	1
Wang, HS	1
Kranias, EG	1
Namdar, M	1
Schepis, T	1
Koepfli, P	1
Gaemperli, O	1
Siegrist, PT	1
Grathwohl, R	1
Valenta, I	1
Delaloye, R	1
Klainguti, M	1
Wyss, CA	1
Lüscher, TF	1
Kaufmann, PA	1
Pedrera-Zamorano, JD	1
Lavado-Garcia, JM	1
Roncero-Martin, R	1
Calderon-Garcia, JF	1
Rodriguez-Dominguez, T	1
Canal-Macias, ML	1
Fermont, J	1
Arts, IM	1
Overeem, S	1
Kleine, BU	1
Schelhaas, HJ	1
Zwarts, MJ	1
Leite, LD	1
Buchholz, NE	1
Keeney, MG	1
Corley, J	1
Jia, X	1
Kyle, JA	1
Gow, AJ	1
Brett, CE	1
Starr, JM	1
McNeill, G	1
Deary, IJ	1
Janowski, E	1
Berríos, M	1
Cleemann, L	1
Morad, M	1
Jacobson, A	2
Green, E	2
Murphy, C	4
Brothers, HM	1
Marchalant, Y	1
Wenk, GL	1
El Maghraoui, A	1
Ghazi, M	1
Gassim, S	1
Ghozlani, I	1
Mounach, A	1
Rezqi, A	1
Dehhaoui, M	1
Wilhelm, EA	1
Jesse, CR	1
Nogueira, CW	1
Marques, S	1
Marin, MT	1
Zancheta, R	1
Paro, AH	1
Possi, AP	1
Cruz, FC	1
Planeta, CS	1
Thornton, AM	1
Zhao, X	1
Weisleder, N	1
Brotto, LS	1
Bougoin, S	1
Nosek, TM	1
Reid, M	1
Hardin, B	1
Pan, Z	1
Ma, J	1
Parness, J	1
Brotto, M	1
Rivard, K	1
Grandy, SA	1
Douillette, A	1
Paradis, P	1
Nemer, M	1
Allen, BG	1
Fiset, C	1
Vila-Luna, S	1
Cabrera-Isidoro, S	1
Vila-Luna, L	1
Juárez-Díaz, I	1
Bata-García, JL	1
Alvarez-Cervera, FJ	1
Zapata-Vázquez, RE	1
Arankowsky-Sandoval, G	1
Heredia-López, F	1
Flores, G	1
Góngora-Alfaro, JL	1
Klaassen, EB	1
de Groot, RH	1
Evers, EA	1
Snel, J	2
Veerman, EC	1
Ligtenberg, AJ	1
Jolles, J	2
Veltman, DJ	1
Sugimura, S	1
Matoba, S	1
Hashiyada, Y	1
Aikawa, Y	1
Ohtake, M	1
Matsuda, H	1
Kobayashi, S	1
Konishi, K	1
Imai, K	1
Sallaberry, C	1
Nunes, F	1
Costa, MS	1
Fioreze, GT	1
Ardais, AP	1
Botton, PH	1
Klaudat, B	1
Forte, T	1
Souza, DO	1
Elisabetsky, E	1
Porciúncula, LO	1
Polasek, TM	1
Patel, F	1
Jensen, BP	1
Sorich, MJ	1
Wiese, MD	1
Doogue, MP	1
Guarino, MP	1
Ribeiro, MJ	1
Sacramento, JF	1
Conde, SV	1
Haase, L	1
Arnal, AV	1
Gore, JL	1
Rudkin, A	1
Bartlett, D	1
Leiter, JC	1
Shukitt-Hale, B	1
Miller, MG	1
Chu, YF	1
Lyle, BJ	1
Joseph, JA	1
Plant, DR	1
Lynch, GS	1
Burke, BE	1
Mushlin, PS	1
Cusack, BJ	1
Olson, SJ	1
Gambliel, HA	1
Olson, RD	1
Rubio, C	1
Moreno, A	1
Briones, A	1
Ivorra, MD	1
D'Ocon, P	1
Vila, E	1
Mace, LC	1
Palmer, BM	1
Brown, DA	1
Jew, KN	1
Lynch, JM	1
Glunt, JM	1
Parsons, TA	1
Cheung, JY	1
Moore, RL	1
Gonzalez, E	1
Messi, ML	1
Zheng, Z	1
Delbono, O	1
van Boxtel, MP	1
Schmitt, JA	2
Bosma, H	1
Yoshimura, H	2
Kato, N	2
Sugai, T	2
Segami, N	2
Onoda, N	2
Terada, S	1
Tabata, I	1
Ginsberg, G	1
Hattis, D	1
Russ, A	1
Sonawane, B	1
Honjo, M	1
Murchison, D	2
Zawieja, DC	1
Griffith, WH	2
Kirchhefer, U	1
Baba, HA	1
Hanske, G	1
Jones, LR	1
Kirchhof, P	1
Schmitz, W	1
Neumann, J	1
Mojet, J	1
Heidema, J	1
Christ-Hazelhof, E	1
Batista, LC	1
Takahashi, RN	1
Abbott, RD	1
Ross, GW	1
White, LR	1
Tanner, CM	1
Masaki, KH	1
Nelson, JS	1
Curb, JD	1
Petrovitch, H	1
Kallus, KW	1
Benton, D	1
Iwamoto, M	1
Onishi, A	1
Fuchimoto, D	1
Somfai, T	1
Suzuki, S	1
Yazaki, S	1
Hashimoto, M	1
Takeda, K	1
Tagami, T	1
Hanada, H	1
Noguchi, J	1
Kaneko, H	1
Nagai, T	1
Kikuchi, K	1
del Corsso, C	1
Ostrovskaya, O	1
McAllister, CE	1
Murray, K	1
Hatton, WJ	1
Gurney, AM	1
Spencer, NJ	1
Drapeau, C	1
Hamel-Hébert, I	1
Robillard, R	1
Selmaoui, B	1
Filipini, D	1
Carrier, J	1
Alshuaib, WB	1
Cherian, SP	1
Hasan, MY	1
Fahim, MA	1
Schmid, TE	1
Eskenazi, B	1
Baumgartner, A	1
Marchetti, F	1
Young, S	1
Weldon, R	1
Anderson, D	1
Wyrobek, AJ	1
Beccafico, S	1
Puglielli, C	1
Pietrangelo, T	1
Bellomo, R	1
Fanò, G	1
Fulle, S	1
Sachse, KT	1
Jackson, EK	1
Wisniewski, SR	1
Gillespie, DG	1
Puccio, AM	1
Clark, RS	1
Dixon, CE	1
Kochanek, PM	1
Gupta, V	1
Lipsitz, LA	1
Björklund, O	1
Kahlström, J	1
Salmi, P	1
Ogren, SO	1
Vahter, M	1
Chen, JF	1
Fredholm, BB	1
Daré, E	1
Peters, JM	1
Boyd, EM	1
Latini, R	1
Bonati, M	1
Marzi, E	1
Tacconi, MT	1
Sadurska, B	1
Bizzi, A	1
Volpe, JJ	1
Bukowskyj, M	1
Nakatsu, K	1
Munt, PW	1
Vornanen, M	1
Hall, JD	1
Almy, RE	1
Scherer, KL	1
Erinoff, L	1
Kelly, PH	1
Basura, M	1
Snodgrass, SR	1
Govindwar, SP	1
Kachole, MS	1
Pawar, SS	1
Cocchi, M	1
Siniscalchi, C	1
Rogato, F	1
Valeriani, A	1
Driscoll, DJ	1
Michael, LH	1
Heaney, RP	1
Blanchard, J	2
Warszawski, D	2
Gorodischer, R	2
Krushinskiĭ, LV	1
Efuni, SN	1
Demurov, EA	1
Flëss, DA	1
Semiokhina, AF	1
Fuller, GN	1
Wiggins, RC	1
Lloyd, HG	1
Stone, TW	1
Ben-Zvi, Z	1
Hyde, RJ	1
Feller, RP	1
Gronert, GA	1
Aldridge, A	2
Neims, AH	2
Sacchetto, R	1
Cliffer, KD	1
Podini, P	1
Villa, A	1
Christensen, BN	1
Volpe, P	1
Li, S	1
Hacker, RR	1
Lorist, MM	1
Mulder, G	1
Kok, A	1
Danieli-Betto, D	1
Betto, R	1
Megighian, A	1
Midrio, M	1
Salviati, G	1
Larsson, L	2
Ramesh, V	1
Kresch, MJ	1
Katz, AM	1
Kim, DH	1
Arciero, PJ	2
Gardner, AW	2
Calles-Escandon, J	1
Benowitz, NL	2
Poehlman, ET	2
Pincheira, J	1
Gallo, C	1
Bravo, M	1
Navarrete, MH	1
Lopez-Saez, JF	1
Huchet, C	1
Léoty, C	2
Massey, LK	2
Bergman, EA	1
Wise, KJ	1
Sherrard, DJ	1
Fukagawa, NK	1
Veirs, H	1
Langeloh, G	1
Etzel, BA	1
Guillet, R	2
Verkhratsky, A	2
Shmigol, A	1
Kirischuk, S	2
Pronchuk, N	1
Kostyuk, P	2
Cazeneuve, C	1
Pons, G	2
Rey, E	2
Treluyer, JM	1
Cresteil, T	1
Thiroux, G	1
D'Athis, P	2
Olive, G	2
Gomez, JP	1
Potreau, D	1
Raymond, G	1
Fiala, P	1
Rossowska, MJ	1
Nakamoto, T	2
Kraus, DM	1
Fischer, JH	1
Reitz, SJ	1
Kecskes, SA	1
Yeh, TF	1
McCulloch, KM	1
Tung, EC	1
Cwik, MJ	1
Dangain, J	1
Neering, IR	1
Damiani, E	1
Margreth, A	1
Bonnet, V	1
Ferrini, RL	1
Barrett-Connor, E	1
Zeeh, J	1
Fuchs, L	1
Bergmann, W	1
Antonin, KH	1
Degel, F	1
Bieck, P	1
Platt, D	1
Houston, DK	1
Johnson, MA	1
Daniel, TD	1
Poon, LW	1
Itoh, T	1
Niwa, H	1
Nagamatsu, M	1
Mitsuma, T	1
Miyakawa, A	1
Pleasure, D	1
Sobue, G	1
Lalo, U	1
Morita, K	1
Maeda, Y	1
Masuda, M	1
Kazusaka, A	1
Imaoka, S	1
Funae, Y	1
Fujita, S	1
Ohta, M	1
Cheuk, G	1
Thomas, KA	1
Kamagata-Kiyoura, Y	1
Wink, CS	1
Yazdani, M	1
Falster, AU	1
Simmons, WB	1
Riedel, WJ	1
Jorissen, BL	1
Chung, WG	1
Park, CS	1
Cho, MH	1
Cha, YN	1
Porter, VA	1
Reeve, HL	1
Cornfield, DN	1
Löhn, M	1
Fürstenau, M	1
Sagach, V	1
Elger, M	1
Schulze, W	1
Luft, FC	1
Haller, H	1
Gollasch, M	1
Norton, MW	1
Mejia, W	1
McCarter, RJ	1
Rossi, R	1
Bottinelli, R	1
Sorrentino, V	1
Reggiani, C	1
Drewnowski, A	1
Matsunaga, N	1
Hattori, K	1
Iizasa, H	1
Kizu, J	1
Takanaka, A	1
Nakashima, E	1
Sy, SK	1
Tang, BK	1
Pastrakuljic, A	1
Roberts, EA	1
Kalow, W	2
Schwartz, LM	1
Ruff, RL	1
Heim, F	3
Müller, S	1
Bartus, RT	1
Mohsin, A	1
Trosko, JE	1
Chu, EH	1
Lehmann, AR	1
Bridges, BA	1
Aranda, JV	2
Collinge, JM	1
Zinman, R	1
Watters, G	1
Kallman, WM	1
Isaac, W	1
Vestal, RE	1
Norris, AH	1
Tobin, JD	1
Cohen, BH	1
Shock, NW	1
Andres, R	1
Hojo, Y	1
Ebata, H	1
Ikeda, U	1
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Shimada, K	1
Imamura, S	1
Kimura, M	1
Hiratsuka, E	1
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Matsuoka, R	1
Relling, MV	1
Lin, JS	1
Ayers, GD	1
Evans, WE	1
Martinez-Serrano, A	1
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Kasprisin, DO	1
Glynn, SH	1
Taylor, F	1
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Hughes, RN	2
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Lowell, BB	1
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Dulloo, AG	1
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Spiegelman, BM	1
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Hunter, RE	1
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Dohanich, GP	1
Dunlap, WP	1
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Gilmore, MM	1
Roskos, KV	1
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van Rijn, J	1
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Warwick, ZS	1
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Coraboeuf, E	1
Lambert, GH	1
Schoeller, DA	1
Kotake, AN	1
Flores, C	1
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Tiplady, B	1
Picard, D	1
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Richard, MO	1
Moran, C	1
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Pedata, F	1
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Hansen, U	1
Skovgaard, LT	1
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Kelleher, P	1
Odumosu, A	1
Yeh, JK	1
Aloia, JF	1
Zhang, JT	1
Setchell, KD	1
Welsh, MB	1
Klooster, MJ	1
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Lim, CK	1
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Schnegg, M	1
Lauterburg, BH	1
Ganote, CE	1
Nayler, WG	1
Glynn, RJ	1
Campion, EW	1
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