Page last updated: 2024-10-24

caffeine and Aging

caffeine has been researched along with Aging in 215 studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" The presence of several bioactive compounds, such as polyphenols and caffeine, implicates coffee as a potential nutritional therapeutic in aging."7.79Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. ( Chu, YF; Joseph, JA; Lyle, BJ; Miller, MG; Shukitt-Hale, B, 2013)
"Our objective was to determine the prevalence and distribution of fasciculations in healthy adults and to assess the effect of age, caffeine and exercise."7.76Prevalence and distribution of fasciculations in healthy adults: Effect of age, caffeine consumption and exercise. ( Arts, IM; Fermont, J; Kleine, BU; Overeem, S; Schelhaas, HJ; Zwarts, MJ, 2010)
" The potency (pD2 value) of phenylephrine increased with age from 3 to 10 weeks, but decreased thereafter from 10 to 80 weeks, while the affinity (pKA value) of phenylephrine to alpha 1-adrenoceptors did not alter with aging."7.68Contractile responses of rat aorta to phenylephrine and serotonin, and aging. ( Ohtsuki, H; Onozuka, S; Shinkai, M; Takayanagi, I, 1991)
"Caffeine was used to manipulate the energetic state of the subjects."6.68Aging, caffeine, and information processing: an event-related potential analysis. ( Kok, A; Lorist, MM; Mulder, G; Snel, J, 1995)
"Caffeine was administrated during all prenatal and postnatal life (CAF, 0."5.51Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence. ( Abreu-Villaça, Y; da Silva Gonçalves, B; Filgueiras, CC; Leal-Rocha, PH; Manhães, AC; Ribeiro-Carvalho, A, 2019)
" The mean hepatic clearances determined by in silico fitting for individual pharmacokinetic models of warfarin and midazolam in the aged group were, respectively, 23% and 56% smaller than those for the young group."5.48Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. ( Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H, 2018)
"Caffeine is a commonly used psychoactive substance and consumption by children and adolescents continues to rise."5.43Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling. ( Archuleta, S; Bachtell, RK; Campeau, S; Levis, SC; Newsom, RJ; O'Neill, CE; Scott, T; Spencer, RL; Stafford, J, 2016)
"d-galactose has been considered a senescent model for age-related neurodegenerative disease."5.42Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. ( Ali, T; Kim, MO; Ullah, F; Ullah, N, 2015)
"Insulin sensitivity was assessed by means of the insulin tolerance test."5.39Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity. ( Conde, SV; Guarino, MP; Ribeiro, MJ; Sacramento, JF, 2013)
"Chronic neuroinflammation is associated with an increase in extracellular levels of glutamate and drugs that limit the effects of glutamate at neuronal receptors have been shown to indirectly reduce the neuroinflammatory response of microglia cells."5.36Caffeine attenuates lipopolysaccharide-induced neuroinflammation. ( Brothers, HM; Marchalant, Y; Wenk, GL, 2010)
"Caffeine half-life was greatly increased in two infants who had cholestatic hepatitis secondary to prolonged parenteral alimentation and one infant who was breast-fed exclusively."5.27Maturational changes of caffeine concentrations and disposition in infancy during maintenance therapy for apnea of prematurity: influence of gestational age, hepatic disease, and breast-feeding. ( Billon, B; Le Guennec, JC; Paré, C, 1985)
"High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e."4.91The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. ( Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP, 2015)
"The most common source of dietary caffeine among the elderly is coffee, with consumption averaging about 200 mg/day."4.80Caffeine and the elderly. ( Massey, LK, 1998)
" The presence of several bioactive compounds, such as polyphenols and caffeine, implicates coffee as a potential nutritional therapeutic in aging."3.79Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. ( Chu, YF; Joseph, JA; Lyle, BJ; Miller, MG; Shukitt-Hale, B, 2013)
"We measured the duration of apnea induced by sustained end-inspiratory lung inflation (the Hering Breuer Reflex, HBR) in unanesthetized infant rat pups aged 4 days (P4) to P20 at body temperatures of 32°C and 36°C."3.79Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups. ( Arnal, AV; Bartlett, D; Gore, JL; Leiter, JC; Rudkin, A, 2013)
"Beneficial effects of caffeine on memory processes have been observed in animal models relevant to neurodegenerative diseases and aging, although the underlying mechanisms remain unknown."3.79Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. ( Ardais, AP; Botton, PH; Costa, MS; Elisabetsky, E; Fioreze, GT; Forte, T; Klaudat, B; Nunes, F; Porciúncula, LO; Sallaberry, C; Souza, DO, 2013)
" However, the aging-related phenomenon could be prevented by caffeine treatment."3.78Oxidative phosphorylation-linked respiration in individual bovine oocytes. ( Aikawa, Y; Hashiyada, Y; Imai, K; Kobayashi, S; Konishi, K; Matoba, S; Matsuda, H; Ohtake, M; Sugimura, S, 2012)
"In this study, the effects of caffeine (CAF) and SCH58261, a selective A(2A) receptor antagonist, on memory impairment and oxidative stress generated by aging in rats were investigated."3.77Protective effect of caffeine and a selective A2A receptor antagonist on impairment of memory and oxidative stress of aged rats. ( Brandão, R; Jesse, CR; Leite, MR; Nogueira, CW; Wilhelm, EA, 2011)
"Our objective was to determine the prevalence and distribution of fasciculations in healthy adults and to assess the effect of age, caffeine and exercise."3.76Prevalence and distribution of fasciculations in healthy adults: Effect of age, caffeine consumption and exercise. ( Arts, IM; Fermont, J; Kleine, BU; Overeem, S; Schelhaas, HJ; Zwarts, MJ, 2010)
"Caffeine, a non-selective adenosine receptor antagonist, has been suggested as a potential drug to counteract age-related cognitive decline since critical changes in adenosinergic neurotransmission occur with aging."3.73Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors. ( Batista, LC; Prediger, RD; Takahashi, RN, 2005)
"Early developmental exposure to caffeine in rats results in decreased susceptibility to certain chemically-induced seizures in the adult."3.69Neonatal caffeine exposure alters seizure susceptibility in rats in an age-related manner. ( Guillet, R, 1995)
"Pregnant Yorkshire gilts (n = 42) were fed caffeine (6 g/d) or served as controls from d 60 of pregnancy until d 4 postpartum to test the effect of caffeine on mammary gland development, milk yield, and feed consumption."3.69The effect of caffeine on mammary gland development and milk yield in primiparous sows. ( Hacker, RR; Li, S, 1995)
" The potency (pD2 value) of phenylephrine increased with age from 3 to 10 weeks, but decreased thereafter from 10 to 80 weeks, while the affinity (pKA value) of phenylephrine to alpha 1-adrenoceptors did not alter with aging."3.68Contractile responses of rat aorta to phenylephrine and serotonin, and aging. ( Ohtsuki, H; Onozuka, S; Shinkai, M; Takayanagi, I, 1991)
"Five neonates (4 premature) and 16 infants (6 prematurely born), 15-588 days old, received caffeine as citrate salt for apnea."3.67Developmental changes of caffeine elimination in infancy. ( Badoual, J; Carrier, O; d'Athis, P; Moran, C; Olive, G; Pons, G; Rey, E; Richard, MO, 1988)
"Caffeine intake was related to moderately better cognitive maintenance over 5 years in older women with vascular disorders."2.78Caffeine and cognitive decline in elderly women at high vascular risk. ( Berr, C; Kang, JH; Ritchie, K; Vercambre, MN, 2013)
" 230 l), and the half-life was slightly increased (19."2.68Influence of age, frailty and liver function on the pharmacokinetics of brofaromine. ( Antonin, KH; Bergmann, W; Bieck, P; Degel, F; Fuchs, L; Platt, D; Zeeh, J, 1996)
" Urine samples were collected for 24 h after dosing and analysed for caffeine and eleven of its metabolites by high-performance liquid chromatography."2.66Comparison of the urinary metabolite profile of caffeine in young and elderly males. ( Blanchard, J; Jonkman, JH; Sawers, SJ; Tang-Liu, DD, 1985)
" While coffee and caffeine are known to enhance short-term memory and cognition, some limited research also suggests that long-term use may protect against cognitive decline or dementia."2.50Current evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer's disease. ( Carman, AJ; Dacks, PA; Fillit, HM; Lane, RF; Shineman, DW, 2014)
"Caffeine is a widely consumed psychoactive drug, which is emerging as a protective agent against AD progression and in aging associated deficits."2.47Modulating Alzheimer's disease through caffeine: a putative link to epigenetics. ( Batalha, VL; Lopes, LV; Marques, S; Outeiro, TF, 2011)
"While acute orthostatic hypotension is usually secondary to medication, fluid or blood loss, or adrenal insufficiency, chronic orthostatic hypotension is frequently due to altered blood pressure regulatory mechanisms and autonomic dysfunction."2.44Orthostatic hypotension in the elderly: diagnosis and treatment. ( Gupta, V; Lipsitz, LA, 2007)
"Children's risks can differ from those in adults for numerous reasons, one being differences in the pharmacokinetic handling of chemicals."2.42Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents. ( Ginsberg, G; Hattis, D; Russ, A; Sonawane, B, 2004)
"26."1.72Sleep Disorders and Future Diagnosis of Parkinsonism: A Prospective Study Using the Canadian Longitudinal Study on Aging. ( Pelletier, A; Postuma, RB; Wolfson, C; Yao, CW; Zolfaghari, S, 2022)
"Caffeine was administrated during all prenatal and postnatal life (CAF, 0."1.51Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence. ( Abreu-Villaça, Y; da Silva Gonçalves, B; Filgueiras, CC; Leal-Rocha, PH; Manhães, AC; Ribeiro-Carvalho, A, 2019)
"Caffeine is a bioactive compound worldwide consumed with effect into the brain."1.51Caffeine Neuroprotection Decreases A2A Adenosine Receptor Content in Aged Mice. ( Alves, MC; Boeck, CR; Damiani, AP; de Abreu, LL; de Andrade, VM; Garcez, ML; Pacheco, R; Rodrigues, L, 2019)
" The mean hepatic clearances determined by in silico fitting for individual pharmacokinetic models of warfarin and midazolam in the aged group were, respectively, 23% and 56% smaller than those for the young group."1.48Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. ( Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H, 2018)
"Caffeine is a well-established performance enhancing nutritional supplement in a young healthy population, however far less is known about how its ergogenicity is affected by increasing age."1.46Is the Ergogenicity of Caffeine Affected by Increasing Age? The Direct Effect of a Physiological Concentration of Caffeine on the Power Output of Maximally Stimulated EDL and Diaphragm Muscle Isolated from the Mouse. ( Cox, VM; Duncan, MJ; James, RS; Tallis, J, 2017)
"Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body."1.46Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice. ( Baba, H; Morimoto, Y; Ogawa, H; Takahashi, T; Tsunematsu, T; Tsuneyama, K; Uehara, H; Watanabe, S, 2017)
"Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear."1.46Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. ( Blanco, P; Bolen, CR; Chang, J; Daburon, S; Davis, MM; Déchanet-Merville, J; Dekker, CL; Douchet, I; Faustin, B; Fragiadakis, GK; Furman, D; Ganio, EA; Gaudilliere, B; Haddad, F; Jojic, V; Kuo, CJ; Lartigue, L; Moreau, JF; Nolan, GP; Spitzer, MH, 2017)
"Caffeine is a commonly used psychoactive substance and consumption by children and adolescents continues to rise."1.43Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling. ( Archuleta, S; Bachtell, RK; Campeau, S; Levis, SC; Newsom, RJ; O'Neill, CE; Scott, T; Spencer, RL; Stafford, J, 2016)
"d-galactose has been considered a senescent model for age-related neurodegenerative disease."1.42Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. ( Ali, T; Kim, MO; Ullah, F; Ullah, N, 2015)
"Caffeine has been reported to produce many beneficial effects for health."1.40Moderate swimming exercise and caffeine supplementation reduce the levels of inflammatory cytokines without causing oxidative stress in tissues of middle-aged rats. ( Bresciani, G; Carvalho, NR; Cechella, JL; da Rocha, JT; Dobrachinski, F; Duarte, MM; Leite, MR; Royes, LF; Soares, FA; Zeni, G, 2014)
"Insulin sensitivity was assessed by means of the insulin tolerance test."1.39Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity. ( Conde, SV; Guarino, MP; Ribeiro, MJ; Sacramento, JF, 2013)
"Predicted metabolic drug clearances (CLPT ) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®."1.39Predicted metabolic drug clearance with increasing adult age. ( Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD, 2013)
"Caffeine treatment at a daily dose of 10 and/or 20 mg/kg, sc was executed during postnatal days 7-11."1.39Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood. ( Kubová, H; Mareš, P; Tchekalarova, JD, 2013)
"Caffeine treatment (5 mg/kg/day) began when animals were ≈4 months old, and lasted for 6 months."1.38Chronic caffeine consumption prevents cognitive decline from young to middle age in rats, and is associated with increased length, branching, and spine density of basal dendrites in CA1 hippocampal neurons. ( Alvarez-Cervera, FJ; Arankowsky-Sandoval, G; Bata-García, JL; Cabrera-Isidoro, S; Flores, G; Góngora-Alfaro, JL; Heredia-López, F; Juárez-Díaz, I; Vila-Luna, L; Vila-Luna, S; Zapata-Vázquez, RE, 2012)
"Chronic neuroinflammation is associated with an increase in extracellular levels of glutamate and drugs that limit the effects of glutamate at neuronal receptors have been shown to indirectly reduce the neuroinflammatory response of microglia cells."1.36Caffeine attenuates lipopolysaccharide-induced neuroinflammation. ( Brothers, HM; Marchalant, Y; Wenk, GL, 2010)
"The prevalence of osteoporosis and osteopenia were 8."1.36Risk factors of osteoporosis in healthy Moroccan men. ( Dehhaoui, M; El Maghraoui, A; Gassim, S; Ghazi, M; Ghozlani, I; Mounach, A; Rezqi, A, 2010)
"Caffeine was then rapidly applied for 5 s at defined intervals from 60 to 300 s."1.33Advancing age alters rapid and spontaneous refilling of caffeine-sensitive calcium stores in sympathetic superior cervical ganglion cells. ( Buchholz, JN; Pearce, WJ; Vanterpool, CK, 2005)
"Excessive daytime sleepiness may be associated with an increased risk of developing Parkinson disease."1.33Excessive daytime sleepiness and subsequent development of Parkinson disease. ( Abbott, RD; Curb, JD; Masaki, KH; Nelson, JS; Petrovitch, H; Ross, GW; Tanner, CM; White, LR, 2005)
"The ryanodine-induced increase was due to influx of extracellular calcium because it was blocked by removal of extracellular calcium or by diltiazem."1.31Fetal rabbit pulmonary artery smooth muscle cell response to ryanodine is developmentally regulated. ( Cornfield, DN; Porter, VA; Reeve, HL, 2000)
"Caffeine is a substance which many people consume in their daily life."1.30Effects of caffeine on the bones of aged, ovariectomized rats. ( Cheuk, G; Falster, AU; Kamagata-Kiyoura, Y; Nakamoto, T; Ohta, M; Simmons, WB; Thomas, KA; Wink, CS; Yazdani, M, 1999)
"The caffeine effects were more pronounced in adult than in newborn fibres while the cyclopiazonic acid effects were larger in newborn preparations."1.29Effects of caffeine and cyclopiazonic acid on contractile proteins of adult and newborn ferret cardiac fibres. ( Bonnet, V; Léoty, C, 1996)
"1."1.29Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults. ( Cazeneuve, C; Cresteil, T; D'Athis, P; Olive, G; Pons, G; Rey, E; Thiroux, G; Treluyer, JM, 1994)
"Caffeine intake was inversely associated with age and waist/hip ratio and positively associated with alcohol consumption."1.29Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. ( Barrett-Connor, E; Ferrini, RL, 1996)
"Caffeine consumption was reliably associated with the self-reported occurrence of somatic symptoms, but not psychological well-being."1.28Self-report reliability and symptomatology of habitual caffeine consumption. ( Bruce, MS; James, JE; Lader, MH; Scott, NR, 1989)
"Caffeine treatment (100 mg/kg for 3 days) increased relative liver weight in female guinea-pigs and decreased it in chicks and female mice, and decreased microsomal protein content in male mice, female guinea-pigs and young rats, and increased it in chicks."1.27In vivo and in vitro effects of caffeine on hepatic mixed-function oxidases in rodents and chicks. ( Govindwar, SP; Kachole, MS; Pawar, SS, 1984)
" This finding suggests that the intestinal absorption of calcium was stimulated by the increase in 1,25(OH)2D production after chronic administration of caffeine."1.27Differential effect of caffeine administration on calcium and vitamin D metabolism in young and adult rats. ( Aloia, JF; Yeh, JK, 1986)
"Caffeine was extracted from diluted serum and saliva samples (10-500 microliter) by adsorption on a small Bond-Elut C18 cartridge and recovered by elution with methanol."1.27Rapid high-performance liquid chromatography assay for salivary and serum caffeine following an oral load. An indicator of liver function. ( Balistreri, WF; Klooster, MJ; Lim, CK; Setchell, KD; Welsh, MB, 1987)
"Caffeine half-life was greatly increased in two infants who had cholestatic hepatitis secondary to prolonged parenteral alimentation and one infant who was breast-fed exclusively."1.27Maturational changes of caffeine concentrations and disposition in infancy during maintenance therapy for apnea of prematurity: influence of gestational age, hepatic disease, and breast-feeding. ( Billon, B; Le Guennec, JC; Paré, C, 1985)
"Caffeine was also analyzed in tissues of newborn and adult dogs 3, 10, and 36 hr after single doses of caffeine (50 mg/kg IV)."1.26Tissue distribution of caffeine in premature infants and in newborn and adult dogs. ( Gorodischer, R; Warszawski, D, 1981)
" Rat pups were given either aminophylline, theophylline, or caffeine in a dosage of 40 mg/kg or 80 mg/kg daily from the second postnatal day through 20 days of age."1.26A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain. ( Fuller, GN; Wiggins, RC, 1981)
"The dose-response relationships for three stimulants have been explored."1.25The effects of age and illumination on the dose-response curves for three stimulants. ( Isaac, W; Kallman, WM, 1975)

Research

Studies (215)

TimeframeStudies, this research(%)All Research%
pre-199064 (29.77)18.7374
1990's46 (21.40)18.2507
2000's44 (20.47)29.6817
2010's57 (26.51)24.3611
2020's4 (1.86)2.80

Authors

AuthorsStudies
Zolfaghari, S1
Yao, CW1
Wolfson, C1
Pelletier, A1
Postuma, RB1
Romero, MA1
Mumford, PW1
Roberson, PA1
Osburn, SC1
Parry, HA1
Kavazis, AN1
Gladden, LB1
Schwartz, TS1
Baker, BA1
Toedebusch, RG1
Childs, TE1
Booth, FW1
Roberts, MD1
França, AP1
Schamne, MG1
de Souza, BS1
da Luz Scheffer, D1
Bernardelli, AK1
Corrêa, T1
de Souza Izídio, G1
Latini, A1
da Silva-Santos, JE1
Canas, PM1
Cunha, RA2
Prediger, RD2
Martínez-Rodríguez, A1
Cuestas-Calero, BJ1
Hernández-García, M1
Martíez-Olcina, M1
Vicente-Martínez, M1
Rubio-Arias, JÁ1
Min, H1
Youn, E1
Shim, YH1
Tallis, J1
James, RS1
Cox, VM1
Duncan, MJ1
Watanabe, S1
Takahashi, T1
Ogawa, H1
Uehara, H1
Tsunematsu, T1
Baba, H1
Morimoto, Y1
Tsuneyama, K1
Takahashi, K2
Yanai, S1
Shimokado, K1
Ishigami, A2
Verster, JC1
Koenig, J1
Toda, A1
Uehara, S1
Inoue, T1
Utoh, M1
Kusama, T1
Shimizu, M1
Uno, Y1
Mogi, M1
Sasaki, E1
Yamazaki, H1
Bakris, GL1
Orbán, C1
Vásárhelyi, Z1
Bajnok, A1
Sava, F1
Toldi, G1
da Silva Gonçalves, B1
Leal-Rocha, PH1
Manhães, AC1
Filgueiras, CC1
Abreu-Villaça, Y1
Ribeiro-Carvalho, A1
Garcez, ML1
Damiani, AP1
Pacheco, R1
Rodrigues, L1
de Abreu, LL1
Alves, MC1
de Andrade, VM1
Boeck, CR1
Vercambre, MN1
Berr, C1
Ritchie, K1
Kang, JH2
Rallis, C1
Bähler, J1
Tchekalarova, J2
Kubová, H3
Mareš, P3
Silva, CG1
Métin, C1
Fazeli, W1
Machado, NJ1
Darmopil, S1
Launay, PS1
Ghestem, A1
Nesa, MP1
Bassot, E1
Szabó, E1
Baqi, Y2
Müller, CE2
Tomé, AR1
Ivanov, A1
Isbrandt, D1
Zilberter, Y1
Esclapez, M1
Bernard, C1
Tchekalarova, JD1
Cechella, JL2
Leite, MR4
Dobrachinski, F2
da Rocha, JT2
Carvalho, NR1
Duarte, MM1
Soares, FA2
Bresciani, G2
Royes, LF2
Zeni, G3
Marcondes Sari, MH1
de Freitas, ML1
Oliveira, LP1
Dalmolin, L1
Brandão, R2
Carman, AJ1
Dacks, PA1
Lane, RF1
Shineman, DW1
Fillit, HM1
Mennella, JA1
Reed, DR1
Roberts, KM1
Mathew, PS1
Mansfield, CJ1
Gai, BM1
Jiang, H1
Wang, C1
Guan, J1
Wang, L1
Li, Z1
Lamboley, CR1
Wyckelsma, VL1
Dutka, TL1
McKenna, MJ1
Murphy, RM1
Lamb, GD1
Poole, RL1
Braak, D1
Gould, TJ1
Cutler, RG1
Camandola, S1
Malott, KF1
Edelhauser, MA1
Mattson, MP1
Ullah, F1
Ali, T1
Ullah, N1
Kim, MO1
Solfrizzi, V1
Panza, F1
Imbimbo, BP1
D'Introno, A1
Galluzzo, L1
Gandin, C1
Misciagna, G1
Guerra, V1
Osella, A1
Baldereschi, M1
Di Carlo, A1
Inzitari, D1
Seripa, D1
Pilotto, A1
Sabbá, C1
Logroscino, G1
Scafato, E1
Frau, L1
Costa, G1
Porceddu, PF1
Khairnar, A1
Castelli, MP1
Ennas, MG1
Madeddu, C1
Wardas, J1
Morelli, M1
Doty, RL1
Heidt, JM1
MacGillivray, MR1
Dsouza, M1
Tracey, EH1
Mirza, N1
Bigelow, D1
O'Neill, CE1
Newsom, RJ1
Stafford, J1
Scott, T1
Archuleta, S1
Levis, SC1
Spencer, RL1
Campeau, S1
Bachtell, RK1
Dance, A1
Batalha, VL2
Ferreira, DG1
Coelho, JE1
Valadas, JS1
Gomes, R1
Temido-Ferreira, M1
Shmidt, T1
Buée, L1
Hamdane, M1
Outeiro, TF2
Bader, M1
Meijsing, SH1
Sadri-Vakili, G1
Blum, D1
Lopes, LV2
Chauhan, G1
Ray, K1
Sahu, S1
Roy, K1
Jain, V1
Wadhwa, M1
Panjwani, U1
Kishore, K1
Singh, SB1
Knapik, JJ1
Trone, DW1
McGraw, S1
Steelman, RA1
Austin, KG1
Lieberman, HR1
Furman, D1
Chang, J1
Lartigue, L1
Bolen, CR1
Haddad, F1
Gaudilliere, B1
Ganio, EA1
Fragiadakis, GK1
Spitzer, MH1
Douchet, I1
Daburon, S1
Moreau, JF1
Nolan, GP1
Blanco, P2
Déchanet-Merville, J1
Dekker, CL1
Jojic, V1
Kuo, CJ1
Davis, MM1
Faustin, B1
Vandenberghe, C1
St-Pierre, V1
Courchesne-Loyer, A1
Hennebelle, M1
Castellano, CA1
Cunnane, SC1
Unno, K1
Yamamoto, H1
Maeda, K1
Takabayashi, F1
Yoshida, H1
Kikunaga, N1
Takamori, N1
Asahina, S1
Iguchi, K1
Sayama, K1
Hoshino, M1
Gregory, JM1
Behringer, EJ2
Vanterpool, CK3
Pearce, WJ3
Wilson, SM3
Buchholz, JN3
Lesk, VE1
Honey, TE1
de Jager, CA1
Yuan, Q1
Han, P1
Dong, M1
Ren, X1
Zhou, X1
Chen, S1
Jones, WK1
Chu, G1
Wang, HS1
Kranias, EG1
Namdar, M1
Schepis, T1
Koepfli, P1
Gaemperli, O1
Siegrist, PT1
Grathwohl, R1
Valenta, I1
Delaloye, R1
Klainguti, M1
Wyss, CA1
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Kirischuk, S2
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Cresteil, T1
Thiroux, G1
D'Athis, P2
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Raymond, G1
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Rossowska, MJ1
Nakamoto, T2
Kraus, DM1
Fischer, JH1
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Kecskes, SA1
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Cohen, BH1
Shock, NW1
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Tsuruya, Y1
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Imamura, S1
Kimura, M1
Hiratsuka, E1
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Kasprisin, DO1
Glynn, SH1
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Miller, KA1
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Britt, B1
Kohno, M1
Murakawa, K1
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Fukui, T1
Takeda, T1
Fujiwara, Y1
Ichihashi, M1
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Kataoka, H1
Takayanagi, I1
Onozuka, S1
Ohtsuki, H1
Shinkai, M1
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Hughes, RN2
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Lowell, BB1
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Maibach, HI1
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Natarajan, AT1
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Scott, NR1
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Planche, C1
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Swift, CG1
Tiplady, B1
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D'Amour, P1
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Splinter, FK1
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Schneider, NG1
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Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Effectiveness and Safety of an Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health Among [NCT05170113]79 participants (Actual)Interventional2021-11-02Completed
A Pilot Study of Facial Recognition Software to Assess Palatability in Pediatric Patients[NCT02923908]12 participants (Actual)Observational2016-12-31Completed
Efficacy of Bitter Taste Blockers on Flavor Acceptance in Pediatric Populations[NCT01407939]215 participants (Actual)Observational2011-04-30Completed
Comparison of Synthetic and Natural Caffeine on Hemodynamic Parameters in Young, Healthy Volunteers: A Randomized, Double Blind, Crossover Study[NCT03495063]0 participants (Actual)Interventional2019-09-16Withdrawn (stopped due to Unable to quantify caffeine)
Residual Immune Activation in HIV-infected Patients on Successful cART: Association Between Inflammasome Activation in Monocytes by Circulating Metabolites and Non AIDS Defining Comorbidities[NCT03191175]55 participants (Actual)Observational2017-07-03Completed
Immune Senescence in the Elderly: Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages[NCT01827462]Phase 4136 participants (Actual)Interventional2007-10-31Completed
Longitudinal Study to Assess the Effects of Whole Coffee Cherry Extract (WCCE)[NCT04986956]323 participants (Actual)Interventional2022-02-01Active, not recruiting
Effects of Insulin on Hypotension and Sarcopenia[NCT03248271]0 participants (Actual)Observational2017-10-01Withdrawn (stopped due to Study design was changed to the study was changed to Insulin, hypotension and sarcopenia.)
Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia[NCT05295784]Phase 118 participants (Anticipated)Interventional2024-06-30Not yet recruiting
CID 0708 - Sex, Aging and Antiretroviral Pharmacokinetics[NCT00666055]11 participants (Actual)Observational2008-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants Who Received the Influenza Vaccine

(NCT01827462)
Timeframe: Day 0 annually while on study

InterventionParticipants (Count of Participants)
18-30 Years Old at Enrollment59
60-79 Years Old at Enrollment37
80-100 Years Old at Enrollment40

Reviews

20 reviews available for caffeine and Aging

ArticleYear
Effect of Supplements on Endurance Exercise in the Older Population: Systematic Review.
    International journal of environmental research and public health, 2020, 07-20, Volume: 17, Issue:14

    Topics: Aged; Aging; Caffeine; Dietary Supplements; Exercise; Exercise Therapy; Female; Humans; Male; Physic

2020
Caffeine intake and its sources: A review of national representative studies.
    Critical reviews in food science and nutrition, 2018, May-24, Volume: 58, Issue:8

    Topics: Aging; Beverages; Caffeine; Global Health; Humans

2018
Current evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer's disease.
    The journal of nutrition, health & aging, 2014, Volume: 18, Issue:4

    Topics: Aging; Alzheimer Disease; Animals; Caffeine; Coffee; Cognition; Cognition Disorders; Humans; Memory,

2014
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.
    Current topics in medicinal chemistry, 2015, Volume: 15, Issue:21

    Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobrom

2015
Optimizing natural fertility.
    Fertility and sterility, 2008, Volume: 90, Issue:5 Suppl

    Topics: Aging; Alcohol Drinking; Caffeine; Coitus; Diet; Female; Fertility; Humans; Life Style; Male; Ovulat

2008
Sleep: a good investment in health and safety.
    Journal of agromedicine, 2008, Volume: 13, Issue:2

    Topics: Age Factors; Aged; Aging; Agriculture; Caffeine; Central Nervous System Stimulants; Fatigue; Female;

2008
Modulating Alzheimer's disease through caffeine: a putative link to epigenetics.
    Journal of Alzheimer's disease : JAD, 2011, Volume: 24 Suppl 2

    Topics: Adenosine A2 Receptor Antagonists; Aging; Alzheimer Disease; Animals; Caffeine; Epigenesis, Genetic;

2011
Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents.
    Journal of toxicology and environmental health. Part A, 2004, Feb-27, Volume: 67, Issue:4

    Topics: Adult; Aging; Caffeine; Environmental Exposure; Half-Life; Humans; Infant, Newborn; Liver; Metabolic

2004
Attention, psychomotor functions and age.
    European journal of nutrition, 2005, Volume: 44, Issue:8

    Topics: Aged; Aging; Attention; Caffeine; Cognition; Glucose; Humans; Memory; Mental Processes; Middle Aged;

2005
Orthostatic hypotension in the elderly: diagnosis and treatment.
    The American journal of medicine, 2007, Volume: 120, Issue:10

    Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents; Blood Pressure

2007
Theophylline reassessed.
    Annals of internal medicine, 1984, Volume: 101, Issue:1

    Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents;

1984
Age-dependent changes in calcium currents and calcium homeostasis in mammalian neurons.
    Annals of the New York Academy of Sciences, 1994, Dec-15, Volume: 747

    Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channels; Cells, Cultured; Cerebral Cor

1994
Caffeine and the elderly.
    Drugs & aging, 1998, Volume: 13, Issue:1

    Topics: Aged; Aging; Bone and Bones; Caffeine; Cardiovascular System; Central Nervous System Stimulants; Die

1998
Nutrients, age and cognitive function.
    Current opinion in clinical nutrition and metabolic care, 1998, Volume: 1, Issue:6

    Topics: Aged; Aging; Caffeine; Cognition; Diet; Dietary Supplements; Eating; Ginkgo biloba; Glucose; Humans;

1998
The science and complexity of bitter taste.
    Nutrition reviews, 2001, Volume: 59, Issue:6

    Topics: Aging; Caffeine; Eating; Feeding Behavior; Flavoring Agents; Food Preferences; Humans; Perception; T

2001
The role of DNA repair and somatic mutation in carcinogenesis.
    Advances in cancer research, 1975, Volume: 21

    Topics: Aging; Base Sequence; Caffeine; Carcinogens; Cell Differentiation; Cell Division; Chromatin; Chromos

1975
DNA repair.
    Essays in biochemistry, 1977, Volume: 13

    Topics: Aging; Alkylating Agents; Animals; Caffeine; Carcinogens; Deoxyribodipyrimidine Photo-Lyase; DNA; DN

1977
[Recent progress in the pharmacology of learning and memory in China].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1986, Volume: 21, Issue:8

    Topics: Aging; Caffeine; Learning; Memory; Panax; Plant Extracts; Plants, Medicinal

1986
Contracture and the calcium paradox.
    Journal of molecular and cellular cardiology, 1985, Volume: 17, Issue:8

    Topics: 2,4-Dinitrophenol; Aging; Animals; Caffeine; Calcium; Dimethyl Sulfoxide; Dinitrophenols; Freeze Fra

1985
Drugs and memory disorders in human aging.
    Behavioral biology, 1972, Volume: 7, Issue:5

    Topics: Adolescent; Adult; Aged; Aging; Amphetamine; Anticonvulsants; Antidepressive Agents; Arousal; Caffei

1972

Trials

15 trials available for caffeine and Aging

ArticleYear
Caffeine and cognitive decline in elderly women at high vascular risk.
    Journal of Alzheimer's disease : JAD, 2013, Volume: 35, Issue:2

    Topics: Aged; Aging; Caffeine; Central Nervous System Stimulants; Cerebrovascular Disorders; Cognition; Cogn

2013
Age-related differences in bitter taste and efficacy of bitter blockers.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt

2014
Age-related differences in bitter taste and efficacy of bitter blockers.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt

2014
Age-related differences in bitter taste and efficacy of bitter blockers.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt

2014
Age-related differences in bitter taste and efficacy of bitter blockers.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt

2014
Caffeine intake increases plasma ketones: an acute metabolic study in humans.
    Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:4

    Topics: Adult; Aging; Alzheimer Disease; Brain; Caffeine; Dietary Supplements; Dose-Response Relationship, D

2017
Caffeine impairs myocardial blood flow response to physical exercise in patients with coronary artery disease as well as in age-matched controls.
    PloS one, 2009, May-22, Volume: 4, Issue:5

    Topics: Aging; Caffeine; Case-Control Studies; Coronary Artery Disease; Coronary Circulation; Exercise; Fema

2009
The effect of caffeine on working memory load-related brain activation in middle-aged males.
    Neuropharmacology, 2013, Volume: 64

    Topics: Adult; Aging; Attention; Caffeine; Central Nervous System Stimulants; Coffee; Cross-Over Studies; Do

2013
Challenging sleep in aging: the effects of 200 mg of caffeine during the evening in young and middle-aged moderate caffeine consumers.
    Journal of sleep research, 2006, Volume: 15, Issue:2

    Topics: Adult; Aged; Aging; Beverages; Caffeine; Circadian Rhythm; Coffee; Cross-Over Studies; Double-Blind

2006
Aging, caffeine, and information processing: an event-related potential analysis.
    Electroencephalography and clinical neurophysiology, 1995, Volume: 96, Issue:5

    Topics: Adolescent; Adult; Aged; Aging; Caffeine; Electroencephalography; Evoked Potentials, Auditory; Femal

1995
Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 1

    Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Body Temperature; Caffeine; Carbon Radioisotop

1995
Interactions between dietary caffeine and calcium on calcium and bone metabolism in older women.
    Journal of the American College of Nutrition, 1994, Volume: 13, Issue:6

    Topics: Adult; Aged; Aging; Alkaline Phosphatase; Bone and Bones; Caffeine; Calcium; Calcium, Dietary; Creat

1994
Acute effects of fructose and glucose ingestion with and without caffeine in young and old humans.
    Metabolism: clinical and experimental, 1995, Volume: 44, Issue:5

    Topics: Adult; Aged; Aging; Alanine; Analysis of Variance; Blood Glucose; Body Temperature Regulation; Caffe

1995
Influence of age, frailty and liver function on the pharmacokinetics of brofaromine.
    European journal of clinical pharmacology, 1996, Volume: 49, Issue:5

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Caffeine; Chromatography, Gas; Cross-Ov

1996
Relationship of blood pressure, heart rate and behavioral mood state to norepinephrine kinetics in younger and older men following caffeine ingestion.
    European journal of clinical nutrition, 1998, Volume: 52, Issue:11

    Topics: Adult; Affect; Aged; Aging; Blood Pressure; Body Composition; Caffeine; Double-Blind Method; Heart R

1998
The effects of age on the response to caffeine.
    Psychopharmacology, 1988, Volume: 94, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Attention; Caffeine; Female; Flicker Fusion; Humans; Male; Postural

1988
Comparison of the urinary metabolite profile of caffeine in young and elderly males.
    British journal of clinical pharmacology, 1985, Volume: 19, Issue:2

    Topics: Adult; Aged; Aging; Caffeine; Glomerular Filtration Rate; Humans; Male; Random Allocation; Theobromi

1985
Effect of maternal caffeine consumption on heart rate and sleep time of breast-fed infants.
    Developmental pharmacology and therapeutics, 1985, Volume: 8, Issue:6

    Topics: Aging; Breast Feeding; Caffeine; Double-Blind Method; Female; Heart Rate; Humans; Infant; Infant, Ne

1985

Other Studies

180 other studies available for caffeine and Aging

ArticleYear
Sleep Disorders and Future Diagnosis of Parkinsonism: A Prospective Study Using the Canadian Longitudinal Study on Aging.
    Journal of Parkinson's disease, 2022, Volume: 12, Issue:1

    Topics: Aged; Aging; Caffeine; Canada; Disorders of Excessive Somnolence; Humans; Longitudinal Studies; Male

2022
Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats.
    American journal of physiology. Cell physiology, 2019, 12-01, Volume: 317, Issue:6

    Topics: Aging; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Caffeine; Chromatin; Chro

2019
Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder.
    Molecular neurobiology, 2020, Volume: 57, Issue:9

    Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Brain; Brain-Derive

2020
Long-Term Caffeine Intake Exerts Protective Effects on Intestinal Aging by Regulating Vitellogenesis and Mitochondrial Function in an Aged
    Nutrients, 2021, Jul-23, Volume: 13, Issue:8

    Topics: Actins; Aging; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caffeine; Intestines;

2021
Is the Ergogenicity of Caffeine Affected by Increasing Age? The Direct Effect of a Physiological Concentration of Caffeine on the Power Output of Maximally Stimulated EDL and Diaphragm Muscle Isolated from the Mouse.
    The journal of nutrition, health & aging, 2017, Volume: 21, Issue:4

    Topics: Aging; Animals; Caffeine; Diaphragm; Female; Mice; Muscle Contraction; Muscle Fatigue; Performance-E

2017
Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice.
    Metabolic syndrome and related disorders, 2017, Volume: 15, Issue:4

    Topics: Aging; Animals; Caffeine; Coffee; Diabetes Mellitus, Type 2; Hyperlipidemias; Insulin-Secreting Cell

2017
Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels.
    Nutrition (Burbank, Los Angeles County, Calif.), 2017, Volume: 38

    Topics: Aging; Animals; Caffeine; Coffee; Energy Metabolism; Lipid Metabolism; Liver; Male; Mice; Mice, Inbr

2017
Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19.
    Xenobiotica; the fate of foreign compounds in biological systems, 2018, Volume: 48, Issue:7

    Topics: Administration, Intravenous; Aging; Animals; Caffeine; Callithrix; Cytochrome P-450 CYP2C19; Genotyp

2018
Anti-aging effects of coffee.
    Aging, 2017, Aug-29, Volume: 9, Issue:8

    Topics: Aged; Aged, 80 and over; Aging; Animals; Caffeine; Coffee; Functional Food; Humans; Lipid Metabolism

2017
MY APPROACH to the elderly patient with resistant hypertension.
    Trends in cardiovascular medicine, 2018, Volume: 28, Issue:1

    Topics: Age Factors; Aging; Antihypertensive Agents; Blood Pressure; Caffeine; Central Nervous System Stimul

2018
Effects of caffeine and phosphodiesterase inhibitors on activation of neonatal T lymphocytes.
    Immunobiology, 2018, Volume: 223, Issue:11

    Topics: Adenosine A2 Receptor Antagonists; Adult; Aging; Caffeine; Calcium Signaling; Cells, Cultured; Cycli

2018
Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence.
    Neuroscience letters, 2019, 03-23, Volume: 696

    Topics: Aging; Animals; Anxiety; Behavior, Animal; Caffeine; Cotinine; Exploratory Behavior; Female; Male; M

2019
Caffeine Neuroprotection Decreases A2A Adenosine Receptor Content in Aged Mice.
    Neurochemical research, 2019, Volume: 44, Issue:4

    Topics: Adenosine A2 Receptor Antagonists; Aging; Animals; Caffeine; Cell Survival; Hippocampus; Male; Mice;

2019
Inhibition of TORC1 signaling and increased lifespan: gained in translation?
    Aging, 2013, Volume: 5, Issue:5

    Topics: Aging; Animals; Antifungal Agents; Caffeine; Caloric Restriction; Mechanistic Target of Rapamycin Co

2013
Effects of caffeine on cortical epileptic afterdischarges in adult rats are modulated by postnatal treatment.
    Acta neurologica Belgica, 2013, Volume: 113, Issue:4

    Topics: Aging; Animals; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Disease Models, Animal

2013
Adenosine receptor antagonists including caffeine alter fetal brain development in mice.
    Science translational medicine, 2013, Aug-07, Volume: 5, Issue:197

    Topics: Aging; Animals; Animals, Newborn; Brain; Caffeine; Cell Movement; Cognition Disorders; Disease Susce

2013
Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood.
    Pharmacological reports : PR, 2013, Volume: 65, Issue:4

    Topics: Aging; Animals; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Myoc

2013
Moderate swimming exercise and caffeine supplementation reduce the levels of inflammatory cytokines without causing oxidative stress in tissues of middle-aged rats.
    Amino acids, 2014, Volume: 46, Issue:5

    Topics: Aging; Animals; Caffeine; Cytokines; Dietary Supplements; Exercise Therapy; Humans; Inflammation; Li

2014
Caffeine and diphenyl diselenide improve long-term memory impaired in middle-aged rats.
    Experimental gerontology, 2014, Volume: 53

    Topics: Aging; Animals; Benzene Derivatives; Caffeine; CREB-Binding Protein; Dietary Supplements; Drug Evalu

2014
Caffeine suppresses exercise-enhanced long-term and location memory in middle-aged rats: Involvement of hippocampal Akt and CREB signaling.
    Chemico-biological interactions, 2014, Nov-05, Volume: 223

    Topics: Aging; Animals; Caffeine; Cyclic AMP Response Element-Binding Protein; Glutamic Acid; Hippocampus; M

2014
Changes of spontaneous parthenogenetic activation and development potential of golden hamster oocytes during the aging process.
    Acta histochemica, 2015, Volume: 117, Issue:1

    Topics: Aging; Animals; Caffeine; Cells, Cultured; Cricetinae; Cumulus Cells; Female; Histone Deacetylase In

2015
Contractile properties and sarcoplasmic reticulum calcium content in type I and type II skeletal muscle fibres in active aged humans.
    The Journal of physiology, 2015, Jun-01, Volume: 593, Issue:11

    Topics: Adult; Aged; Aging; Caffeine; Calcium; Female; Humans; In Vitro Techniques; Magnesium; Male; Muscle

2015
Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice.
    Behavioural brain research, 2016, Feb-01, Volume: 298, Issue:Pt A

    Topics: Aging; Animals; Anxiety; Caffeine; Central Nervous System Stimulants; Conditioning, Psychological; D

2016
Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain.
    Neurochemistry international, 2015, Volume: 90

    Topics: Aging; Animals; Antioxidants; Brain; Caffeine; Cognition Disorders; Disease Models, Animal; Galactos

2015
Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging.
    Journal of Alzheimer's disease : JAD, 2015, Volume: 47, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Caffeine; Coffee; Cognitive Dysfunction; Depression; Feeding Behavio

2015
Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent.
    Journal of neurochemistry, 2016, Volume: 136, Issue:1

    Topics: Age Factors; Aging; Animals; Caffeine; Dopaminergic Neurons; Drug Synergism; Inflammation; Male; Mic

2016
Influences of age, tongue region, and chorda tympani nerve sectioning on signal detection measures of lingual taste sensitivity.
    Physiology & behavior, 2016, Mar-01, Volume: 155

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Caffeine; Chorda Tympani Nerve; Dietary Sucrose;

2016
Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling.
    Psychoneuroendocrinology, 2016, Volume: 67

    Topics: Adrenocorticotropic Hormone; Aging; Amygdala; Animals; Anxiety; Behavior, Animal; Caffeine; Corticos

2016
Smart drugs: A dose of intelligence.
    Nature, 2016, Mar-03, Volume: 531, Issue:7592

    Topics: Aging; Amphetamines; Animals; Benzhydryl Compounds; Biomedical Enhancement; Caffeine; Child; Cogniti

2016
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
    Scientific reports, 2016, 08-11, Volume: 6

    Topics: Aging; Animals; Caffeine; Cell Nucleus; Cognitive Dysfunction; Corticosterone; Humans; Hypothalamo-H

2016
Adenosine A1 receptor antagonist mitigates deleterious effects of sleep deprivation on adult neurogenesis and spatial reference memory in rats.
    Neuroscience, 2016, Nov-19, Volume: 337

    Topics: Adenosine A1 Receptor Antagonists; Aging; Animals; Caffeine; Doublecortin Protein; Hippocampus; Male

2016
Caffeine Use among Active Duty Navy and Marine Corps Personnel.
    Nutrients, 2016, Oct-09, Volume: 8, Issue:10

    Topics: Adolescent; Adult; Aging; Beverages; Caffeine; Cross-Sectional Studies; Data Collection; Female; Hum

2016
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
    Nature medicine, 2017, Volume: 23, Issue:2

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;

2017
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
    Nature medicine, 2017, Volume: 23, Issue:2

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;

2017
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
    Nature medicine, 2017, Volume: 23, Issue:2

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;

2017
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
    Nature medicine, 2017, Volume: 23, Issue:2

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;

2017
Protection of brain and pancreas from high-fat diet: effects of catechin and caffeine.
    Physiology & behavior, 2009, Feb-16, Volume: 96, Issue:2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Body Weight; Brain; Caffeine; Catechin; Central Nervous

2009
Advancing age alters the contribution of calcium release from smooth endoplasmic reticulum stores in superior cervical ganglion cells.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2009, Volume: 64, Issue:1

    Topics: Aging; Animals; Caffeine; Calcium; Electric Stimulation; Endoplasmic Reticulum; Intracellular Fluid;

2009
The effect of recent consumption of caffeine-containing foodstuffs on neuropsychological tests in the elderly.
    Dementia and geriatric cognitive disorders, 2009, Volume: 27, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Caffeine; Central Nervous System Stimulants; Cognition; Female; Food

2009
Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:5

    Topics: Aging; Animals; Arrhythmias, Cardiac; Caffeine; Calcium Signaling; Calcium-Binding Proteins; Disease

2009
Effect of beer drinking on ultrasound bone mass in women.
    Nutrition (Burbank, Los Angeles County, Calif.), 2009, Volume: 25, Issue:10

    Topics: Adult; Aging; Alcohol Drinking; Analysis of Variance; Beer; Body Mass Index; Bone Density; Caffeine;

2009
Prevalence and distribution of fasciculations in healthy adults: Effect of age, caffeine consumption and exercise.
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2010, Volume: 11, Issue:1-2

    Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Aging; Beverages; Caffeine; Central Nervous System

2010
Maturation and long-term hypoxia alters Ca2+-induced Ca2+ release in sheep cerebrovascular sympathetic neurons.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 107, Issue:4

    Topics: Age Factors; Aging; Animals; Caffeine; Calcium; Calcium Signaling; Cerebral Arteries; Cyclic ADP-Rib

2009
Caffeine consumption and cognitive function at age 70: the Lothian Birth Cohort 1936 study.
    Psychosomatic medicine, 2010, Volume: 72, Issue:2

    Topics: Aged; Aging; Caffeine; Child; Coffee; Cognition; Cognition Disorders; Cohort Studies; Drinking Behav

2010
Developmental aspects of cardiac Ca(2+) signaling: interplay between RyR- and IP(3)R-gated Ca(2+) stores.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:6

    Topics: Adenosine Triphosphate; Aging; Animals; Boron Compounds; Caffeine; Calcium; Calcium Channel Blockers

2010
Age-related functional changes in gustatory and reward processing regions: An fMRI study.
    NeuroImage, 2010, Nov-01, Volume: 53, Issue:2

    Topics: Adult; Aged; Aging; Brain; Brain Mapping; Caffeine; Central Nervous System Stimulants; Citric Acid;

2010
Caffeine attenuates lipopolysaccharide-induced neuroinflammation.
    Neuroscience letters, 2010, Aug-16, Volume: 480, Issue:2

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aging; Animals; Caffeine; Chro

2010
Risk factors of osteoporosis in healthy Moroccan men.
    BMC musculoskeletal disorders, 2010, Jul-05, Volume: 11

    Topics: Absorptiometry, Photon; Adult; Age Distribution; Aged; Aging; Body Mass Index; Body Weight; Bone Dis

2010
Postnatal period of caffeine treatment and time of testing modulate the effect of acute caffeine on cortical epileptic afterdischarges in rats.
    Brain research, 2010, Oct-14, Volume: 1356

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Anticonvulsants; Caffeine; Cerebral Cortex; Con

2010
Protective effect of caffeine and a selective A2A receptor antagonist on impairment of memory and oxidative stress of aged rats.
    Experimental gerontology, 2011, Volume: 46, Issue:4

    Topics: Adenosine A2 Receptor Antagonists; Aging; Animals; Ascorbic Acid; Brain; Caffeine; Male; Memory; Mem

2011
Comparison of caffeine-induced locomotor activity between adolescent and adult rats.
    European journal of pharmacology, 2011, Jun-25, Volume: 660, Issue:2-3

    Topics: Aging; Animals; Caffeine; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Male; Mo

2011
Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.
    Aging, 2011, Volume: 3, Issue:6

    Topics: Aging; Anilides; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Sig

2011
Overexpression of type 1 angiotensin II receptors impairs excitation-contraction coupling in the mouse heart.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:5

    Topics: Age Factors; Aging; Animals; Blotting, Western; Caffeine; Calcium Channels, L-Type; Calcium Signalin

2011
Chronic caffeine consumption prevents cognitive decline from young to middle age in rats, and is associated with increased length, branching, and spine density of basal dendrites in CA1 hippocampal neurons.
    Neuroscience, 2012, Jan-27, Volume: 202

    Topics: Aging; Animals; Anxiety; CA1 Region, Hippocampal; Caffeine; Central Nervous System Stimulants; Cogni

2012
Oxidative phosphorylation-linked respiration in individual bovine oocytes.
    The Journal of reproduction and development, 2012, Volume: 58, Issue:6

    Topics: Adenosine Triphosphate; Aging; Animals; Caffeine; Cattle; Cell Respiration; Female; Mitochondria; Oo

2012
Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats.
    Neuropharmacology, 2013, Volume: 64

    Topics: Aging; Animals; Avoidance Learning; Behavior, Animal; Brain-Derived Neurotrophic Factor; Caffeine; C

2013
Predicted metabolic drug clearance with increasing adult age.
    British journal of clinical pharmacology, 2013, Volume: 75, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; M

2013
Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity.
    Age (Dordrecht, Netherlands), 2013, Volume: 35, Issue:5

    Topics: Aging; AMP-Activated Protein Kinases; Animals; Blood Glucose; Blotting, Western; Caffeine; Diabetes

2013
Can age-related CNS taste differences be detected as early as middle age? Evidence from fMRI.
    Neuroscience, 2013, Mar-01, Volume: 232

    Topics: Adult; Aging; Analysis of Variance; Body Mass Index; Brain; Brain Mapping; Caffeine; Dietary Sucrose

2013
Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups.
    Respiratory physiology & neurobiology, 2013, Mar-01, Volume: 186, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Apnea; Body Temperature; Caffeine; Central Nervous System Stimulan

2013
Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging.
    Age (Dordrecht, Netherlands), 2013, Volume: 35, Issue:6

    Topics: Aging; Animals; Behavior, Animal; Beverages; Caffeine; Central Nervous System Stimulants; Coffee; Co

2013
Excitation-contraction coupling and sarcoplasmic reticulum function in mechanically skinned fibres from fast skeletal muscles of aged mice.
    The Journal of physiology, 2002, Aug-15, Volume: 543, Issue:Pt 1

    Topics: Aging; Animals; Caffeine; Calcium; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbre

2002
Decreased sensitivity of neonatal rabbit sarcoplasmic reticulum to anthracycline cardiotoxicity.
    Cardiovascular toxicology, 2002, Volume: 2, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Antibiotics, Antineoplastic; Caffeine; Daunorubicin; Doxorubicin;

2002
Alterations by age of calcium handling in rat resistance arteries.
    Journal of cardiovascular pharmacology, 2002, Volume: 40, Issue:6

    Topics: Aging; Animals; Caffeine; Calcium; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Phenylephrin

2002
Influence of age and run training on cardiac Na+/Ca2+ exchange.
    Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 95, Issue:5

    Topics: Action Potentials; Aging; Animals; Blotting, Western; Caffeine; Calcium; Exercise Test; Male; Myocar

2003
Insulin-like growth factor-1 prevents age-related decrease in specific force and intracellular Ca2+ in single intact muscle fibres from transgenic mice.
    The Journal of physiology, 2003, Nov-01, Volume: 552, Issue:Pt 3

    Topics: Aging; Anatomy, Cross-Sectional; Animals; Caffeine; Calcium; Extremities; Humans; Insulin-Like Growt

2003
The effects of habitual caffeine use on cognitive change: a longitudinal perspective.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Chi-Square Distribution; Cognition; Feeding Behavio

2003
Age-dependent emergence of oscillatory signal flow between the primary and secondary visual cortices in rat brain slices.
    Brain research, 2003, Nov-14, Volume: 990, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Caffeine; Calcium; Electric Stimulation; Electrophysiol

2003
Effects of acute bouts of running and swimming exercise on PGC-1alpha protein expression in rat epitrochlearis and soleus muscle.
    American journal of physiology. Endocrinology and metabolism, 2004, Volume: 286, Issue:2

    Topics: Aging; Aminoimidazole Carboxamide; Animals; Caffeine; Forelimb; Glycogen; Male; Muscle, Skeletal; Pr

2004
Age-dependent emergence of a parieto-insular corticocortical signal flow in developing rats.
    Brain research. Developmental brain research, 2004, Mar-22, Volume: 149, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Caffeine; Central Nervous System Stim

2004
Reduced mitochondrial buffering of voltage-gated calcium influx in aged rat basal forebrain neurons.
    Cell calcium, 2004, Volume: 36, Issue:1

    Topics: Aging; Animals; Buffers; Caffeine; Calcium; Calcium Channels; In Vitro Techniques; Kinetics; Male; M

2004
Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:5

    Topics: Aging; Animals; Atrial Function; Caffeine; Calcium; Calcium-Binding Proteins; Dogs; Electric Stimula

2004
Effect of concentration on taste-taste interactions in foods for elderly and young subjects.
    Chemical senses, 2004, Volume: 29, Issue:8

    Topics: Acetic Acid; Adult; Aged; Aging; Caffeine; Female; Food Preservatives; Humans; Male; Middle Aged; Se

2004
Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors.
    Neurobiology of aging, 2005, Volume: 26, Issue:6

    Topics: Aging; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Discrimination Learni

2005
Advancing age alters rapid and spontaneous refilling of caffeine-sensitive calcium stores in sympathetic superior cervical ganglion cells.
    Journal of applied physiology (Bethesda, Md. : 1985), 2005, Volume: 99, Issue:3

    Topics: Aging; Animals; Caffeine; Calcium; Calcium Signaling; Cells, Cultured; Dose-Response Relationship, D

2005
Excessive daytime sleepiness and subsequent development of Parkinson disease.
    Neurology, 2005, Nov-08, Volume: 65, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Brain; Caffeine; Causality; Cognition Disorders; Cohort Studies; Com

2005
Effects of caffeine treatment on aged porcine oocytes: parthenogenetic activation ability, chromosome condensation and development to the blastocyst stage after somatic cell nuclear transfer.
    Zygote (Cambridge, England), 2005, Volume: 13, Issue:4

    Topics: Aging; Animals; Blastocyst; Caffeine; Chromatin Assembly and Disassembly; Embryo, Mammalian; Female;

2005
Effects of aging on Ca2+ signaling in murine mesenteric arterial smooth muscle cells.
    Mechanisms of ageing and development, 2006, Volume: 127, Issue:4

    Topics: Aging; Animals; Barium; Caffeine; Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Membrane

2006
Modulation of neuronal [Ca2+]i by caffeine is altered with aging.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2006, Volume: 24, Issue:6

    Topics: Aging; Animals; Caffeine; Calcium; Central Nervous System Stimulants; Hippocampus; Male; Mice; Mice,

2006
The effects of male age on sperm DNA damage in healthy non-smokers.
    Human reproduction (Oxford, England), 2007, Volume: 22, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Coffee; Comet Assay; DNA Damage; Humans; Life Style

2007
Age-dependent effects on functional aspects in human satellite cells.
    Annals of the New York Academy of Sciences, 2007, Volume: 1100

    Topics: Adenosine Triphosphate; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Caffeine; Calcium; Femal

2007
Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2008, Volume: 28, Issue:2

    Topics: Adult; Aging; Brain Injuries; Caffeine; Central Nervous System Depressants; Central Nervous System S

2008
The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration.
    Toxicology, 2007, Nov-30, Volume: 241, Issue:3

    Topics: Aging; Animals; Brain; Caffeine; Environmental Pollutants; Female; Gene Deletion; Lactation; Male; M

2007
The influence of sex and age in albino rats given a daily oral dose of caffeine at a high dose level.
    Canadian journal of physiology and pharmacology, 1967, Volume: 45, Issue:2

    Topics: Adrenal Glands; Aging; Animals; Body Weight; Brain Chemistry; Caffeine; Drinking; Eating; Female; Gl

1967
Caffeine disposition and effects in young and one-year old rats.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:8

    Topics: Aging; Animals; Brain Chemistry; Caffeine; Fatty Acids, Nonesterified; Half-Life; In Vitro Technique

1980
Effects of methylxanthines on lipid synthesis in developing neural systems.
    Seminars in perinatology, 1981, Volume: 5, Issue:4

    Topics: Acetyl-CoA Carboxylase; Aging; Aminophylline; Brain; Caffeine; Cell Division; Cell Line; Cholesterol

1981
Effects of caffeine on the mechanical properties of developing rat heart ventricles.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1984, Volume: 78, Issue:2

    Topics: Action Potentials; Aging; Animals; Caffeine; Female; Heart; In Vitro Techniques; Male; Myocardial Co

1984
DNA repair in cultured human fibroblasts does not decline with donor age.
    Experimental cell research, 1982, Volume: 139, Issue:2

    Topics: Aged; Aging; Caffeine; Cell Line; Child, Preschool; DNA Repair; DNA, Viral; Fibroblasts; Humans; Inf

1982
Six-hydroxydopamine induced hyperactivity: neither sex differences nor caffeine stimulation are found.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:5

    Topics: Aging; alpha-Methyltyrosine; Animals; Body Weight; Brain; Brain Chemistry; Caffeine; Catecholamines;

1984
In vivo and in vitro effects of caffeine on hepatic mixed-function oxidases in rodents and chicks.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1984, Volume: 22, Issue:5

    Topics: Aging; Animals; Caffeine; Chickens; Cytochromes; Female; Guinea Pigs; In Vitro Techniques; Male; Mic

1984
Free fatty acid levels in habitual coffee drinkers in relation to quantities consumed, sex and age.
    Annals of nutrition & metabolism, 1983, Volume: 27, Issue:6

    Topics: Adult; Aging; Caffeine; Coffee; Drinking Behavior; Fatty Acids, Nonesterified; Female; Humans; Male;

1983
Age-related changes in tetanic contraction of ventricular myocardium.
    Developmental pharmacology and therapeutics, 1984, Volume: 7, Issue:2

    Topics: Aging; Animals; Caffeine; Calcium; Dogs; In Vitro Techniques; Myocardial Contraction

1984
Nutritional factors and estrogen in age-related bone loss.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1982, Volume: 5, Issue:2-3

    Topics: Adult; Aged; Aging; Bone Resorption; Caffeine; Calcium; Calcium, Dietary; Dietary Proteins; Estrogen

1982
Protein binding of caffeine in young and elderly males.
    Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:12

    Topics: Adolescent; Adult; Aged; Aging; Blood Proteins; Caffeine; Humans; Male; Membranes; Protein Binding;

1982
Tissue distribution of caffeine in premature infants and in newborn and adult dogs.
    Pediatric pharmacology (New York, N.Y.), 1981, Volume: 1, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Caffeine; Dogs; Humans; Infant; Infant, Newborn; Infant, Premature

1981
[Protective action of hyperbaric oxygenation in acute circulatory disorders in rats of different ages].
    Doklady Akademii nauk SSSR, 1980, Volume: 255, Issue:4

    Topics: Acoustic Stimulation; Acute Disease; Aging; Animals; Caffeine; Cardiovascular Diseases; Female; Hype

1980
A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain.
    Brain research, 1981, Jun-01, Volume: 213, Issue:2

    Topics: Aging; Aminophylline; Animals; Body Weight; Brain; Caffeine; Intracellular Membranes; Myelin Sheath;

1981
Chronic methylxanthine treatment in rats: a comparison of Wistar and Fischer 344 strains.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 14, Issue:6

    Topics: Aging; Aminophylline; Animals; Behavior, Animal; Caffeine; Diet; Rats; Rats, Inbred F344; Sex Factor

1981
Caffeine metabolism in liver slices during postnatal development in the rat.
    Biochemical pharmacology, 1981, Dec-01, Volume: 30, Issue:23

    Topics: Aging; Allopurinol; Animals; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; In V

1981
Age and sex effects on taste of sucrose, NaCl, citric acid and caffeine.
    Neurobiology of aging, 1981,Winter, Volume: 2, Issue:4

    Topics: Adult; Aged; Aging; Caffeine; Citrates; Citric Acid; Discrimination, Psychological; Humans; Sodium C

1981
Contracture responses and energy stores in quadriceps muscle from humans age 7-82 years.
    Human biology, 1980, Volume: 52, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Caffeine; Child; Energy Metabolism; Halothane; Humans; Middle Aged;

1980
Relationship between the clearance of caffeine and its 7-N-demethylation in developing beagle puppies.
    Biochemical pharmacology, 1980, Jul-01, Volume: 29, Issue:13

    Topics: Aging; Animals; Caffeine; Dealkylation; Dogs; Female; Kinetics; Theobromine; Theophylline; Xanthines

1980
Intracellular Ca2+ stores in chick cerebellum Purkinje neurons: ontogenetic and functional studies.
    The American journal of physiology, 1995, Volume: 269, Issue:5 Pt 1

    Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases;

1995
The effect of caffeine on mammary gland development and milk yield in primiparous sows.
    Journal of animal science, 1995, Volume: 73, Issue:2

    Topics: Aging; Animals; Animals, Suckling; Birth Weight; Caffeine; DNA; Eating; Female; Lactation; Mammary G

1995
Effects of age on sarcoplasmic reticulum properties and histochemical composition of fast- and slow-twitch rat muscles.
    Acta physiologica Scandinavica, 1995, Volume: 154, Issue:1

    Topics: Aging; Animals; Body Weight; Caffeine; Calcium; Histocytochemistry; Male; Muscle Fibers, Fast-Twitch

1995
Characterization of Ca(2+)-release channels in fetal and adult rat hearts.
    The American journal of physiology, 1995, Volume: 269, Issue:3 Pt 2

    Topics: Aging; Animals; Caffeine; Calcium; Calcium Channels; Fetus; Heart; Heart Ventricles; Kinetics; Myoca

1995
G2 repair and aging: influence of donor age on chromosomal aberrations in human lymphocytes.
    Mutation research, 1993, Volume: 295, Issue:2

    Topics: Adenosine; Adult; Aged; Aging; Caffeine; Cell Cycle; Child, Preschool; Chromosome Aberrations; DNA R

1993
Sarcoplasmic reticulum function in newborn ferret cremaster skeletal muscles.
    European journal of pharmacology, 1994, Dec-12, Volume: 271, Issue:1

    Topics: Adenosine Triphosphatases; Aging; Animals; Animals, Newborn; Caffeine; Calcium; Calcium-Transporting

1994
Effects of neonatal exposure to caffeine on adenosine A1 receptor ontogeny using autoradiography.
    Brain research. Developmental brain research, 1994, Oct-14, Volume: 82, Issue:1-2

    Topics: Adenosine; Administration, Oral; Aging; Animals; Animals, Newborn; Autoradiography; Brain; Caffeine;

1994
Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults.
    British journal of clinical pharmacology, 1994, Volume: 37, Issue:5

    Topics: Adult; Aging; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CY

1994
Intracellular calcium transients from newborn rat cardiomyocytes in primary culture.
    Cell calcium, 1994, Volume: 15, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Biological Transport; Caffeine; Calcium; Cell Differentiation; Cel

1994
Are there any differences in the excitation-contraction coupling of the working myocardium of adult and newborn guinea-pigs?
    Physiological research, 1993, Volume: 42, Issue:5

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Caffeine; Calcium; Electrophysiology; Guinea Pi

1993
Effects of chronic caffeine feeding on the activities of oxygen free radical defense enzymes in the growing rat heart and liver.
    Experientia, 1994, May-15, Volume: 50, Issue:5

    Topics: Aging; Animals; Caffeine; Catalase; Copper; Female; Glutathione Peroxidase; Heart; Iron; Liver; Myoc

1994
Alterations in theophylline metabolism during the first year of life.
    Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:4

    Topics: Aging; Analysis of Variance; Caffeine; Humans; Infant; Infant, Newborn; Linear Models; Metabolic Cle

1993
Effect of caffeine and high potassium on normal and dystrophic mouse EDL muscles at various developmental stages.
    Muscle & nerve, 1993, Volume: 16, Issue:1

    Topics: Aging; Analysis of Variance; Animals; Caffeine; Calcium; Disease Models, Animal; Female; In Vitro Te

1993
Neonatal caffeine exposure alters seizure susceptibility in rats in an age-related manner.
    Brain research. Developmental brain research, 1995, Oct-27, Volume: 89, Issue:1

    Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Convulsants; Disease Susceptibilit

1995
Age-related abnormalities in regulation of the ryanodine receptor in rat fast-twitch muscle.
    Cell calcium, 1996, Volume: 19, Issue:1

    Topics: Aging; Animals; Antibiotics, Antineoplastic; Binding Sites; Caffeine; Calcium; Calcium Channel Block

1996
Calcium homeostasis in aged neurones.
    Life sciences, 1996, Volume: 59, Issue:5-6

    Topics: Aging; Animals; Caffeine; Calcium; Cells, Cultured; Homeostasis; In Vitro Techniques; Male; Membrane

1996
Effects of caffeine and cyclopiazonic acid on contractile proteins of adult and newborn ferret cardiac fibres.
    Journal of molecular and cellular cardiology, 1996, Volume: 28, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Caffeine; Calcium; Contractile Proteins; F

1996
Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study.
    American journal of epidemiology, 1996, Oct-01, Volume: 144, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Caffeine; Estradiol; Estrone; Female; H

1996
Health and dietary characteristics of supplement users in an elderly population.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1997, Volume: 67, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Alcohol Drinking; Ascorbic Acid; Caffeine; Calcium, Dietary; Cardiov

1997
Nerve growth factor maintains regulation of intracellular calcium in neonatal sympathetic neurons but not in mature or aged neurons.
    Neuroscience, 1998, Volume: 82, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Cells, Cultured; Central Nervous System Stimula

1998
Developmental changes in purinergic calcium signalling in rat neocortical neurones.
    Brain research. Developmental brain research, 1998, Nov-01, Volume: 111, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium Channels; Calcium Signaling; Cell Membrane; Cere

1998
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
    Biochemical pharmacology, 1998, May-01, Volume: 55, Issue:9

    Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 En

1998
Effects of caffeine on the bones of aged, ovariectomized rats.
    Annals of nutrition & metabolism, 1999, Volume: 43, Issue:1

    Topics: Aging; Animals; Body Weight; Bone and Bones; Bone Density; Caffeine; Central Nervous System Stimulan

1999
Age-related alterations in caffeine-sensitive calcium stores and mitochondrial buffering in rat basal forebrain.
    Cell calcium, 1999, Volume: 25, Issue:6

    Topics: Aging; Animals; Caffeine; Calcium; Fluorescent Dyes; Fura-2; Homeostasis; Male; Mitochondria; Neuron

1999
Effect of age and smoking on in vivo CYP1A2, flavin-containing monooxygenase, and xanthine oxidase activities in Koreans: determination by caffeine metabolism.
    Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:3

    Topics: Adult; Aged; Aging; Asian People; Caffeine; Case-Control Studies; Chromatography, High Pressure Liqu

2000
Fetal rabbit pulmonary artery smooth muscle cell response to ryanodine is developmentally regulated.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 279, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Cells, Cultured; Embryonic and Fetal Developmen

2000
Ignition of calcium sparks in arterial and cardiac muscle through caveolae.
    Circulation research, 2000, Nov-24, Volume: 87, Issue:11

    Topics: Aging; Animals; Animals, Newborn; beta-Cyclodextrins; Caffeine; Calcium; Calcium Channels, L-Type; C

2000
Age, fatigue, and excitation-contraction coupling in masseter muscles of rats.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2001, Volume: 56, Issue:2

    Topics: Aging; Animals; Caffeine; Diet; Hydrogen-Ion Concentration; Male; Masseter Muscle; Muscle Contractio

2001
Response to caffeine and ryanodine receptor isoforms in mouse skeletal muscles.
    American journal of physiology. Cell physiology, 2001, Volume: 281, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Caffeine; Diaphragm; Hindlimb; In Vitro Techniques; Mice; Mice, Kn

2001
Application of the PKCYP-test in cases of altered CYP1A2 for multiple CYP systems in rat models of disease.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:9

    Topics: Acetanilides; Aging; Algorithms; Animals; Antibodies, Blocking; Caffeine; Central Nervous System Sti

2001
Detailed characterization of experimentally derived human hepatic CYP1A1 activity and expression using differential inhibition of ethoxyresorufin O-deethylation by fluvoxamine.
    European journal of clinical pharmacology, 2001, Volume: 57, Issue:5

    Topics: Aging; Caffeine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Enzyme Inhibitors; Fluvoxamine; H

2001
Changes in contractile properties of skeletal muscle during developmentally programmed atrophy and death.
    American journal of physiology. Cell physiology, 2002, Volume: 282, Issue:6

    Topics: Aging; Animals; Apoptosis; Caffeine; Electric Stimulation; In Vitro Techniques; Larva; Manduca; Memb

2002
[The correlations between aging and drug effects (author's transl)].
    Aktuelle Gerontologie, 1976, Volume: 6, Issue:7

    Topics: Age Factors; Aging; Animals; Caffeine; Cysteamine; Energy Metabolism; Glycolysis; Hepatectomy; Human

1976
The age-dependent effect of caffeine on the plasma noradrenaline content in white mice.
    Aktuelle Gerontologie, 1978, Volume: 8, Issue:5

    Topics: Aging; Animals; Caffeine; Calcium; Mice; Norepinephrine; Receptors, Adrenergic, beta; Receptors, Dru

1978
Four stimulants of the central nervous system: effects on short-term memory in young versus aged monkeys.
    Journal of the American Geriatrics Society, 1979, Volume: 27, Issue:7

    Topics: Aging; Animals; Caffeine; Central Nervous System Stimulants; Female; Haplorhini; Macaca mulatta; Mal

1979
Changes in free amino acid level due to physical and chemical agents in ageing Drosophila.
    Experientia, 1979, Aug-15, Volume: 35, Issue:8

    Topics: Aging; Amino Acids; Animals; Caffeine; Drosophila melanogaster; Female; Male; Sex Factors

1979
Caffeine metabolism in the newborn.
    Clinical pharmacology and therapeutics, 1979, Volume: 25, Issue:4

    Topics: Adult; Aging; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Humans; Infant; Inf

1979
Maturation of caffeine elimination in infancy.
    Archives of disease in childhood, 1979, Volume: 54, Issue:12

    Topics: Adult; Aging; Caffeine; Half-Life; Humans; Infant; Infant, Newborn; Kinetics; Metabolic Clearance Ra

1979
The effects of age and illumination on the dose-response curves for three stimulants.
    Psychopharmacologia, 1975, Volume: 40, Issue:4

    Topics: Adaptation, Psychological; Aging; Animals; Arousal; Caffeine; Darkness; Dextroamphetamine; Dose-Resp

1975
Antipyrine metabolism in man: influence of age, alcohol, caffeine, and smoking.
    Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Alcohol Drinking; Antipyrine; Body Water; Caffeine; Cof

1975
Enhanced spontaneous calcium efflux and decrease of calcium-dependent calcium release from the isolated perfused heart of spontaneously hypertensive rats.
    Journal of hypertension, 1992, Volume: 10, Issue:6

    Topics: Aging; Animals; Caffeine; Calcium; Calcium Radioisotopes; Egtazic Acid; Half-Life; Heart; Hypertensi

1992
Effect of caffeine on expression of cardiac myosin heavy chain gene in adult hypothyroid and fetal rats.
    Circulation research, 1992, Volume: 71, Issue:5

    Topics: Aging; Animals; Caffeine; Cyclic AMP; Fetal Heart; Fetus; Gene Expression; Hypothyroidism; Myocardiu

1992
Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities.
    Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:6

    Topics: Adolescent; Adult; Aging; Analysis of Variance; Arylamine N-Acetyltransferase; Caffeine; Child; Chil

1992
Calcium binding to the cytosol and calcium extrusion mechanisms in intact synaptosomes and their alterations with aging.
    The Journal of biological chemistry, 1992, Mar-05, Volume: 267, Issue:7

    Topics: Aging; Animals; Biological Transport; Caffeine; Calcium; Calcium-Transporting ATPases; Carbonyl Cyan

1992
Moderate and severe reactions in blood donors.
    Transfusion, 1992, Volume: 32, Issue:1

    Topics: Adjustment Disorders; Adult; Aging; Blood Donors; Body Weight; Caffeine; Female; Humans; Male

1992
Pharmacogenetics of caffeine and caffeine-halothane contractures in biopsies of human skeletal muscle.
    Pharmacogenetics, 1991, Volume: 1, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Caffeine; Child; Child, Preschool; Female; Genetic Variation; Haloth

1991
Plasma immunoreactive endothelin-1 in experimental malignant hypertension.
    Hypertension (Dallas, Tex. : 1979), 1991, Volume: 18, Issue:1

    Topics: Aging; Analysis of Variance; Angiotensin II; Animals; Blood Pressure; Blood Urea Nitrogen; Body Weig

1991
A mechanism for relief of replication blocks by activation of unused origins and age-dependent change in the caffeine susceptibility in xeroderma pigmentosum variant.
    Mutation research, 1991, Volume: 254, Issue:1

    Topics: Adult; Aging; Caffeine; Cell Survival; Cells, Cultured; Child; DNA Repair; DNA Replication; Drug Res

1991
Contractile responses of rat aorta to phenylephrine and serotonin, and aging.
    General pharmacology, 1991, Volume: 22, Issue:1

    Topics: Aging; Animals; Aorta, Thoracic; Caffeine; Calcium; Fura-2; In Vitro Techniques; Isometric Contracti

1991
Urinary zinc excretion in infancy.
    Journal of trace elements and electrolytes in health and disease, 1990, Volume: 4, Issue:1

    Topics: Aging; Caffeine; Fetus; Humans; Infant Food; Infant, Newborn; Male; Milk, Human; Reproducibility of

1990
Sex-and age-dependent effects of prenatal exposure to caffeine on open-field behavior, emergence latency and adrenal weights in rats.
    Life sciences, 1990, Volume: 47, Issue:22

    Topics: Adrenal Glands; Aging; Animals; Behavior, Animal; Caffeine; Exploratory Behavior; Female; Male; Moto

1990
Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine.
    Endocrinology, 1990, Volume: 126, Issue:3

    Topics: Adipose Tissue, Brown; Aging; Animals; Body Temperature; Caffeine; Complement Factor D; Drug Combina

1990
Effects of uric acid and caffeine on A1 adenosine receptor binding in developing rat brain.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:4

    Topics: Adenosine; Aging; Animals; Binding, Competitive; Brain; Caffeine; Male; Oxonic Acid; Rats; Rats, Inb

1990
Age influences responses of rat isolated aorta and pulmonary artery to the calcium channel agonist, Bay K 8664, and to potassium and calcium.
    Journal of cardiovascular pharmacology, 1989, Volume: 13, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1989
Aging is associated with increased Weber ratios for caffeine, but not for sucrose.
    Perception & psychophysics, 1989, Volume: 46, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Caffeine; Differential Threshold; Female; Humans; Sucrose; Taste; Ta

1989
The effect of aging on percutaneous absorption in man.
    Journal of pharmacokinetics and biopharmaceutics, 1989, Volume: 17, Issue:6

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents; Aspirin; B

1989
Increased frequency of spontaneous and X-ray-induced chromosomal aberrations in lymphocytes from neonates and the influence of caffeine--an in vitro study.
    Mutation research, 1989, Volume: 226, Issue:1

    Topics: Adult; Aging; Caffeine; Cells, Cultured; Chromosome Aberrations; Gestational Age; Humans; Infant, Ne

1989
Self-report reliability and symptomatology of habitual caffeine consumption.
    British journal of clinical pharmacology, 1989, Volume: 27, Issue:4

    Topics: Adolescent; Adult; Aging; Alcohol Drinking; Caffeine; Diet; Female; Humans; Male; Research Design; S

1989
Aging and chemosensory perception of and preference for nutritionally significant stimuli.
    Annals of the New York Academy of Sciences, 1989, Volume: 561

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Blood Chemical Analysis; Caffeine; Caseins; Diet;

1989
Use of flavor-amplified foods to improve nutritional status in elderly patients.
    Annals of the New York Academy of Sciences, 1989, Volume: 561

    Topics: Aged; Aging; Amiloride; Bretylium Tosylate; Caffeine; Flavoring Agents; Humans; Inosine; Inosine Mon

1989
Comparison of the effects of halothane on skinned myocardial fibers from newborn and adult rabbit: II. Effects on sarcoplasmic reticulum.
    Anesthesiology, 1989, Volume: 71, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Halothane; Heart; In Vitro Techniques; Male; My

1989
Age-related changes of action potential plateau shape in isolated human atrial fibers.
    The American journal of physiology, 1985, Volume: 249, Issue:4 Pt 2

    Topics: 4-Aminopyridine; Action Potentials; Adult; Aged; Aging; Aminopyridines; Atrial Function; Caffeine; H

1985
The effect of age, gender, and sexual maturation on the caffeine breath test.
    Developmental pharmacology and therapeutics, 1986, Volume: 9, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aging; Breath Tests; Caffeine; Carbon Dioxide; Child; Child, Prescho

1986
Premenopausal bone mineral content relates to height, weight and calcium intake during early adulthood.
    Bone and mineral, 1988, Volume: 4, Issue:3

    Topics: Adult; Aging; Body Height; Body Weight; Bone and Bones; Caffeine; Calcium, Dietary; Contraceptives,

1988
Developmental changes of caffeine elimination in infancy.
    Developmental pharmacology and therapeutics, 1988, Volume: 11, Issue:5

    Topics: Aging; Apnea; Caffeine; Drug Administration Schedule; Gestational Age; Half-Life; Humans; Infant; In

1988
Purinergic modulation of cortical acetylcholine release is decreased in aging rats.
    Experimental gerontology, 1988, Volume: 23, Issue:3

    Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aging; Animals; Caffeine; Dose-Response

1988
Age, fiber type composition and in vitro contracture responses in human malignant hyperthermia.
    Acta anaesthesiologica Scandinavica, 1988, Volume: 32, Issue:2

    Topics: Adolescent; Adult; Aging; Caffeine; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia;

1988
The effects of ageing on aminopyrine and caffeine breath tests in the rat.
    Fundamental & clinical pharmacology, 1987, Volume: 1, Issue:6

    Topics: Aging; Aminopyrine; Animals; Breath Tests; Caffeine; Female; Half-Life; Longitudinal Studies; Male;

1987
Differential effect of caffeine administration on calcium and vitamin D metabolism in young and adult rats.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1986, Volume: 1, Issue:3

    Topics: Aging; Animals; Body Weight; Caffeine; Calcitriol; Calcium; Disease Models, Animal; Eating; Feces; I

1986
Rapid high-performance liquid chromatography assay for salivary and serum caffeine following an oral load. An indicator of liver function.
    Journal of chromatography, 1987, Jan-09, Volume: 385

    Topics: Adult; Aging; Caffeine; Child; Chromatography, High Pressure Liquid; Half-Life; Humans; Indicators a

1987
The role of the sarcoplasmic reticulum in the response of ferret and rat heart muscle to acidosis.
    The Journal of physiology, 1987, Volume: 384

    Topics: Acidosis; Aequorin; Aging; Ammonium Chloride; Animals; Caffeine; Calcium; Ferrets; Hydrogen-Ion Conc

1987
Quantitative liver function in the elderly assessed by galactose elimination capacity, aminopyrine demethylation and caffeine clearance.
    Journal of hepatology, 1986, Volume: 3, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aminopyrine; Breath Tests; Caffeine; Female; Galactose; Human

1986
Behavioral effects of prenatal exposure to caffeine in rats.
    Life sciences, 1986, Mar-10, Volume: 38, Issue:10

    Topics: Aging; Animals; Behavior, Animal; Caffeine; Emotions; Female; Male; Motor Activity; Pregnancy; Prena

1986
The development of benign prostatic hyperplasia among volunteers in the Normative Aging Study.
    American journal of epidemiology, 1985, Volume: 121, Issue:1

    Topics: Adult; Aged; Aging; Alcohol Drinking; Blood Glucose; Blood Pressure; Boston; Caffeine; Humans; Hyper

1985
Maturational changes of caffeine concentrations and disposition in infancy during maintenance therapy for apnea of prematurity: influence of gestational age, hepatic disease, and breast-feeding.
    Pediatrics, 1985, Volume: 76, Issue:5

    Topics: Aging; Apnea; Breast Feeding; Caffeine; Cholestasis; Citrates; Drug Combinations; Gestational Age; H

1985
[Elimination of caffeine and metamizol in in vivo characterization of cytochrome P-450 dependent biotransformation reactions in aged humans].
    Die Pharmazie, 1985, Volume: 40, Issue:11

    Topics: Aged; Aging; Aminopyrine; Biotransformation; Caffeine; Creatinine; Cytochrome P-450 Enzyme System; D

1985
Age-correlated effects of caffeine on non-irradiated and UV-irradiated Paramecium Aurelia.
    Journal of gerontology, 1974, Volume: 29, Issue:3

    Topics: Aging; Autoradiography; Caffeine; Cell Survival; DNA; DNA Repair; Paramecium; Radiation Effects; Thy

1974
[When may aged persons drink coffee?].
    Minerva medica, 1972, Sep-05, Volume: 63, Issue:61

    Topics: Adrenal Glands; Aged; Aging; Caffeine; Cardiovascular System; Central Nervous System; Coffee; Corona

1972
The effect of ageing, caffeine-treatment, and ionizing-radiation on nucleic acid synthesis in the mouse liver.
    Life sciences. Pt. 2: Biochemistry, general and molecular biology, 1971, Nov-22, Volume: 10, Issue:22

    Topics: Aging; Animals; Caffeine; Carbon Isotopes; DNA; Hepatectomy; Liver; Liver Regeneration; Male; Mice;

1971
[Effect of age on the effects of caffeine on the function and metabolism of the heart].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:4

    Topics: Adenosine Triphosphate; Aging; Animals; Blood Pressure; Caffeine; Cardiac Output; Carotid Arteries;

1970
[New paths in geriatric therapy].
    Zeitschrift fur Alternsforschung, 1965, Volume: 18, Issue:3

    Topics: Adult; Aged; Aging; Caffeine; Capillary Permeability; Cardiovascular System; Epinephrine; Humans; Hy

1965