caffeine has been researched along with Aging in 215 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Excerpt | Relevance | Reference |
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" The presence of several bioactive compounds, such as polyphenols and caffeine, implicates coffee as a potential nutritional therapeutic in aging." | 7.79 | Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. ( Chu, YF; Joseph, JA; Lyle, BJ; Miller, MG; Shukitt-Hale, B, 2013) |
"Our objective was to determine the prevalence and distribution of fasciculations in healthy adults and to assess the effect of age, caffeine and exercise." | 7.76 | Prevalence and distribution of fasciculations in healthy adults: Effect of age, caffeine consumption and exercise. ( Arts, IM; Fermont, J; Kleine, BU; Overeem, S; Schelhaas, HJ; Zwarts, MJ, 2010) |
" The potency (pD2 value) of phenylephrine increased with age from 3 to 10 weeks, but decreased thereafter from 10 to 80 weeks, while the affinity (pKA value) of phenylephrine to alpha 1-adrenoceptors did not alter with aging." | 7.68 | Contractile responses of rat aorta to phenylephrine and serotonin, and aging. ( Ohtsuki, H; Onozuka, S; Shinkai, M; Takayanagi, I, 1991) |
"Caffeine was used to manipulate the energetic state of the subjects." | 6.68 | Aging, caffeine, and information processing: an event-related potential analysis. ( Kok, A; Lorist, MM; Mulder, G; Snel, J, 1995) |
"Caffeine was administrated during all prenatal and postnatal life (CAF, 0." | 5.51 | Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence. ( Abreu-Villaça, Y; da Silva Gonçalves, B; Filgueiras, CC; Leal-Rocha, PH; Manhães, AC; Ribeiro-Carvalho, A, 2019) |
" The mean hepatic clearances determined by in silico fitting for individual pharmacokinetic models of warfarin and midazolam in the aged group were, respectively, 23% and 56% smaller than those for the young group." | 5.48 | Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. ( Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H, 2018) |
"Caffeine is a commonly used psychoactive substance and consumption by children and adolescents continues to rise." | 5.43 | Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling. ( Archuleta, S; Bachtell, RK; Campeau, S; Levis, SC; Newsom, RJ; O'Neill, CE; Scott, T; Spencer, RL; Stafford, J, 2016) |
"d-galactose has been considered a senescent model for age-related neurodegenerative disease." | 5.42 | Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. ( Ali, T; Kim, MO; Ullah, F; Ullah, N, 2015) |
"Insulin sensitivity was assessed by means of the insulin tolerance test." | 5.39 | Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity. ( Conde, SV; Guarino, MP; Ribeiro, MJ; Sacramento, JF, 2013) |
"Chronic neuroinflammation is associated with an increase in extracellular levels of glutamate and drugs that limit the effects of glutamate at neuronal receptors have been shown to indirectly reduce the neuroinflammatory response of microglia cells." | 5.36 | Caffeine attenuates lipopolysaccharide-induced neuroinflammation. ( Brothers, HM; Marchalant, Y; Wenk, GL, 2010) |
"Caffeine half-life was greatly increased in two infants who had cholestatic hepatitis secondary to prolonged parenteral alimentation and one infant who was breast-fed exclusively." | 5.27 | Maturational changes of caffeine concentrations and disposition in infancy during maintenance therapy for apnea of prematurity: influence of gestational age, hepatic disease, and breast-feeding. ( Billon, B; Le Guennec, JC; Paré, C, 1985) |
"High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e." | 4.91 | The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. ( Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP, 2015) |
"The most common source of dietary caffeine among the elderly is coffee, with consumption averaging about 200 mg/day." | 4.80 | Caffeine and the elderly. ( Massey, LK, 1998) |
" The presence of several bioactive compounds, such as polyphenols and caffeine, implicates coffee as a potential nutritional therapeutic in aging." | 3.79 | Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. ( Chu, YF; Joseph, JA; Lyle, BJ; Miller, MG; Shukitt-Hale, B, 2013) |
"We measured the duration of apnea induced by sustained end-inspiratory lung inflation (the Hering Breuer Reflex, HBR) in unanesthetized infant rat pups aged 4 days (P4) to P20 at body temperatures of 32°C and 36°C." | 3.79 | Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups. ( Arnal, AV; Bartlett, D; Gore, JL; Leiter, JC; Rudkin, A, 2013) |
"Beneficial effects of caffeine on memory processes have been observed in animal models relevant to neurodegenerative diseases and aging, although the underlying mechanisms remain unknown." | 3.79 | Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. ( Ardais, AP; Botton, PH; Costa, MS; Elisabetsky, E; Fioreze, GT; Forte, T; Klaudat, B; Nunes, F; Porciúncula, LO; Sallaberry, C; Souza, DO, 2013) |
" However, the aging-related phenomenon could be prevented by caffeine treatment." | 3.78 | Oxidative phosphorylation-linked respiration in individual bovine oocytes. ( Aikawa, Y; Hashiyada, Y; Imai, K; Kobayashi, S; Konishi, K; Matoba, S; Matsuda, H; Ohtake, M; Sugimura, S, 2012) |
"In this study, the effects of caffeine (CAF) and SCH58261, a selective A(2A) receptor antagonist, on memory impairment and oxidative stress generated by aging in rats were investigated." | 3.77 | Protective effect of caffeine and a selective A2A receptor antagonist on impairment of memory and oxidative stress of aged rats. ( Brandão, R; Jesse, CR; Leite, MR; Nogueira, CW; Wilhelm, EA, 2011) |
"Our objective was to determine the prevalence and distribution of fasciculations in healthy adults and to assess the effect of age, caffeine and exercise." | 3.76 | Prevalence and distribution of fasciculations in healthy adults: Effect of age, caffeine consumption and exercise. ( Arts, IM; Fermont, J; Kleine, BU; Overeem, S; Schelhaas, HJ; Zwarts, MJ, 2010) |
"Caffeine, a non-selective adenosine receptor antagonist, has been suggested as a potential drug to counteract age-related cognitive decline since critical changes in adenosinergic neurotransmission occur with aging." | 3.73 | Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors. ( Batista, LC; Prediger, RD; Takahashi, RN, 2005) |
"Early developmental exposure to caffeine in rats results in decreased susceptibility to certain chemically-induced seizures in the adult." | 3.69 | Neonatal caffeine exposure alters seizure susceptibility in rats in an age-related manner. ( Guillet, R, 1995) |
"Pregnant Yorkshire gilts (n = 42) were fed caffeine (6 g/d) or served as controls from d 60 of pregnancy until d 4 postpartum to test the effect of caffeine on mammary gland development, milk yield, and feed consumption." | 3.69 | The effect of caffeine on mammary gland development and milk yield in primiparous sows. ( Hacker, RR; Li, S, 1995) |
" The potency (pD2 value) of phenylephrine increased with age from 3 to 10 weeks, but decreased thereafter from 10 to 80 weeks, while the affinity (pKA value) of phenylephrine to alpha 1-adrenoceptors did not alter with aging." | 3.68 | Contractile responses of rat aorta to phenylephrine and serotonin, and aging. ( Ohtsuki, H; Onozuka, S; Shinkai, M; Takayanagi, I, 1991) |
"Five neonates (4 premature) and 16 infants (6 prematurely born), 15-588 days old, received caffeine as citrate salt for apnea." | 3.67 | Developmental changes of caffeine elimination in infancy. ( Badoual, J; Carrier, O; d'Athis, P; Moran, C; Olive, G; Pons, G; Rey, E; Richard, MO, 1988) |
"Caffeine intake was related to moderately better cognitive maintenance over 5 years in older women with vascular disorders." | 2.78 | Caffeine and cognitive decline in elderly women at high vascular risk. ( Berr, C; Kang, JH; Ritchie, K; Vercambre, MN, 2013) |
" 230 l), and the half-life was slightly increased (19." | 2.68 | Influence of age, frailty and liver function on the pharmacokinetics of brofaromine. ( Antonin, KH; Bergmann, W; Bieck, P; Degel, F; Fuchs, L; Platt, D; Zeeh, J, 1996) |
" Urine samples were collected for 24 h after dosing and analysed for caffeine and eleven of its metabolites by high-performance liquid chromatography." | 2.66 | Comparison of the urinary metabolite profile of caffeine in young and elderly males. ( Blanchard, J; Jonkman, JH; Sawers, SJ; Tang-Liu, DD, 1985) |
" While coffee and caffeine are known to enhance short-term memory and cognition, some limited research also suggests that long-term use may protect against cognitive decline or dementia." | 2.50 | Current evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer's disease. ( Carman, AJ; Dacks, PA; Fillit, HM; Lane, RF; Shineman, DW, 2014) |
"Caffeine is a widely consumed psychoactive drug, which is emerging as a protective agent against AD progression and in aging associated deficits." | 2.47 | Modulating Alzheimer's disease through caffeine: a putative link to epigenetics. ( Batalha, VL; Lopes, LV; Marques, S; Outeiro, TF, 2011) |
"While acute orthostatic hypotension is usually secondary to medication, fluid or blood loss, or adrenal insufficiency, chronic orthostatic hypotension is frequently due to altered blood pressure regulatory mechanisms and autonomic dysfunction." | 2.44 | Orthostatic hypotension in the elderly: diagnosis and treatment. ( Gupta, V; Lipsitz, LA, 2007) |
"Children's risks can differ from those in adults for numerous reasons, one being differences in the pharmacokinetic handling of chemicals." | 2.42 | Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents. ( Ginsberg, G; Hattis, D; Russ, A; Sonawane, B, 2004) |
"26." | 1.72 | Sleep Disorders and Future Diagnosis of Parkinsonism: A Prospective Study Using the Canadian Longitudinal Study on Aging. ( Pelletier, A; Postuma, RB; Wolfson, C; Yao, CW; Zolfaghari, S, 2022) |
"Caffeine was administrated during all prenatal and postnatal life (CAF, 0." | 1.51 | Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence. ( Abreu-Villaça, Y; da Silva Gonçalves, B; Filgueiras, CC; Leal-Rocha, PH; Manhães, AC; Ribeiro-Carvalho, A, 2019) |
"Caffeine is a bioactive compound worldwide consumed with effect into the brain." | 1.51 | Caffeine Neuroprotection Decreases A2A Adenosine Receptor Content in Aged Mice. ( Alves, MC; Boeck, CR; Damiani, AP; de Abreu, LL; de Andrade, VM; Garcez, ML; Pacheco, R; Rodrigues, L, 2019) |
" The mean hepatic clearances determined by in silico fitting for individual pharmacokinetic models of warfarin and midazolam in the aged group were, respectively, 23% and 56% smaller than those for the young group." | 1.48 | Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. ( Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H, 2018) |
"Caffeine is a well-established performance enhancing nutritional supplement in a young healthy population, however far less is known about how its ergogenicity is affected by increasing age." | 1.46 | Is the Ergogenicity of Caffeine Affected by Increasing Age? The Direct Effect of a Physiological Concentration of Caffeine on the Power Output of Maximally Stimulated EDL and Diaphragm Muscle Isolated from the Mouse. ( Cox, VM; Duncan, MJ; James, RS; Tallis, J, 2017) |
"Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body." | 1.46 | Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice. ( Baba, H; Morimoto, Y; Ogawa, H; Takahashi, T; Tsunematsu, T; Tsuneyama, K; Uehara, H; Watanabe, S, 2017) |
"Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear." | 1.46 | Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. ( Blanco, P; Bolen, CR; Chang, J; Daburon, S; Davis, MM; Déchanet-Merville, J; Dekker, CL; Douchet, I; Faustin, B; Fragiadakis, GK; Furman, D; Ganio, EA; Gaudilliere, B; Haddad, F; Jojic, V; Kuo, CJ; Lartigue, L; Moreau, JF; Nolan, GP; Spitzer, MH, 2017) |
"Caffeine is a commonly used psychoactive substance and consumption by children and adolescents continues to rise." | 1.43 | Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling. ( Archuleta, S; Bachtell, RK; Campeau, S; Levis, SC; Newsom, RJ; O'Neill, CE; Scott, T; Spencer, RL; Stafford, J, 2016) |
"d-galactose has been considered a senescent model for age-related neurodegenerative disease." | 1.42 | Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. ( Ali, T; Kim, MO; Ullah, F; Ullah, N, 2015) |
"Caffeine has been reported to produce many beneficial effects for health." | 1.40 | Moderate swimming exercise and caffeine supplementation reduce the levels of inflammatory cytokines without causing oxidative stress in tissues of middle-aged rats. ( Bresciani, G; Carvalho, NR; Cechella, JL; da Rocha, JT; Dobrachinski, F; Duarte, MM; Leite, MR; Royes, LF; Soares, FA; Zeni, G, 2014) |
"Insulin sensitivity was assessed by means of the insulin tolerance test." | 1.39 | Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity. ( Conde, SV; Guarino, MP; Ribeiro, MJ; Sacramento, JF, 2013) |
"Predicted metabolic drug clearances (CLPT ) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®." | 1.39 | Predicted metabolic drug clearance with increasing adult age. ( Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD, 2013) |
"Caffeine treatment at a daily dose of 10 and/or 20 mg/kg, sc was executed during postnatal days 7-11." | 1.39 | Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood. ( Kubová, H; Mareš, P; Tchekalarova, JD, 2013) |
"Caffeine treatment (5 mg/kg/day) began when animals were ≈4 months old, and lasted for 6 months." | 1.38 | Chronic caffeine consumption prevents cognitive decline from young to middle age in rats, and is associated with increased length, branching, and spine density of basal dendrites in CA1 hippocampal neurons. ( Alvarez-Cervera, FJ; Arankowsky-Sandoval, G; Bata-García, JL; Cabrera-Isidoro, S; Flores, G; Góngora-Alfaro, JL; Heredia-López, F; Juárez-Díaz, I; Vila-Luna, L; Vila-Luna, S; Zapata-Vázquez, RE, 2012) |
"Chronic neuroinflammation is associated with an increase in extracellular levels of glutamate and drugs that limit the effects of glutamate at neuronal receptors have been shown to indirectly reduce the neuroinflammatory response of microglia cells." | 1.36 | Caffeine attenuates lipopolysaccharide-induced neuroinflammation. ( Brothers, HM; Marchalant, Y; Wenk, GL, 2010) |
"The prevalence of osteoporosis and osteopenia were 8." | 1.36 | Risk factors of osteoporosis in healthy Moroccan men. ( Dehhaoui, M; El Maghraoui, A; Gassim, S; Ghazi, M; Ghozlani, I; Mounach, A; Rezqi, A, 2010) |
"Caffeine was then rapidly applied for 5 s at defined intervals from 60 to 300 s." | 1.33 | Advancing age alters rapid and spontaneous refilling of caffeine-sensitive calcium stores in sympathetic superior cervical ganglion cells. ( Buchholz, JN; Pearce, WJ; Vanterpool, CK, 2005) |
"Excessive daytime sleepiness may be associated with an increased risk of developing Parkinson disease." | 1.33 | Excessive daytime sleepiness and subsequent development of Parkinson disease. ( Abbott, RD; Curb, JD; Masaki, KH; Nelson, JS; Petrovitch, H; Ross, GW; Tanner, CM; White, LR, 2005) |
"The ryanodine-induced increase was due to influx of extracellular calcium because it was blocked by removal of extracellular calcium or by diltiazem." | 1.31 | Fetal rabbit pulmonary artery smooth muscle cell response to ryanodine is developmentally regulated. ( Cornfield, DN; Porter, VA; Reeve, HL, 2000) |
"Caffeine is a substance which many people consume in their daily life." | 1.30 | Effects of caffeine on the bones of aged, ovariectomized rats. ( Cheuk, G; Falster, AU; Kamagata-Kiyoura, Y; Nakamoto, T; Ohta, M; Simmons, WB; Thomas, KA; Wink, CS; Yazdani, M, 1999) |
"The caffeine effects were more pronounced in adult than in newborn fibres while the cyclopiazonic acid effects were larger in newborn preparations." | 1.29 | Effects of caffeine and cyclopiazonic acid on contractile proteins of adult and newborn ferret cardiac fibres. ( Bonnet, V; Léoty, C, 1996) |
"1." | 1.29 | Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults. ( Cazeneuve, C; Cresteil, T; D'Athis, P; Olive, G; Pons, G; Rey, E; Thiroux, G; Treluyer, JM, 1994) |
"Caffeine intake was inversely associated with age and waist/hip ratio and positively associated with alcohol consumption." | 1.29 | Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. ( Barrett-Connor, E; Ferrini, RL, 1996) |
"Caffeine consumption was reliably associated with the self-reported occurrence of somatic symptoms, but not psychological well-being." | 1.28 | Self-report reliability and symptomatology of habitual caffeine consumption. ( Bruce, MS; James, JE; Lader, MH; Scott, NR, 1989) |
"Caffeine treatment (100 mg/kg for 3 days) increased relative liver weight in female guinea-pigs and decreased it in chicks and female mice, and decreased microsomal protein content in male mice, female guinea-pigs and young rats, and increased it in chicks." | 1.27 | In vivo and in vitro effects of caffeine on hepatic mixed-function oxidases in rodents and chicks. ( Govindwar, SP; Kachole, MS; Pawar, SS, 1984) |
" This finding suggests that the intestinal absorption of calcium was stimulated by the increase in 1,25(OH)2D production after chronic administration of caffeine." | 1.27 | Differential effect of caffeine administration on calcium and vitamin D metabolism in young and adult rats. ( Aloia, JF; Yeh, JK, 1986) |
"Caffeine was extracted from diluted serum and saliva samples (10-500 microliter) by adsorption on a small Bond-Elut C18 cartridge and recovered by elution with methanol." | 1.27 | Rapid high-performance liquid chromatography assay for salivary and serum caffeine following an oral load. An indicator of liver function. ( Balistreri, WF; Klooster, MJ; Lim, CK; Setchell, KD; Welsh, MB, 1987) |
"Caffeine half-life was greatly increased in two infants who had cholestatic hepatitis secondary to prolonged parenteral alimentation and one infant who was breast-fed exclusively." | 1.27 | Maturational changes of caffeine concentrations and disposition in infancy during maintenance therapy for apnea of prematurity: influence of gestational age, hepatic disease, and breast-feeding. ( Billon, B; Le Guennec, JC; Paré, C, 1985) |
"Caffeine was also analyzed in tissues of newborn and adult dogs 3, 10, and 36 hr after single doses of caffeine (50 mg/kg IV)." | 1.26 | Tissue distribution of caffeine in premature infants and in newborn and adult dogs. ( Gorodischer, R; Warszawski, D, 1981) |
" Rat pups were given either aminophylline, theophylline, or caffeine in a dosage of 40 mg/kg or 80 mg/kg daily from the second postnatal day through 20 days of age." | 1.26 | A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain. ( Fuller, GN; Wiggins, RC, 1981) |
"The dose-response relationships for three stimulants have been explored." | 1.25 | The effects of age and illumination on the dose-response curves for three stimulants. ( Isaac, W; Kallman, WM, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 64 (29.77) | 18.7374 |
1990's | 46 (21.40) | 18.2507 |
2000's | 44 (20.47) | 29.6817 |
2010's | 57 (26.51) | 24.3611 |
2020's | 4 (1.86) | 2.80 |
Authors | Studies |
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Zolfaghari, S | 1 |
Yao, CW | 1 |
Wolfson, C | 1 |
Pelletier, A | 1 |
Postuma, RB | 1 |
Romero, MA | 1 |
Mumford, PW | 1 |
Roberson, PA | 1 |
Osburn, SC | 1 |
Parry, HA | 1 |
Kavazis, AN | 1 |
Gladden, LB | 1 |
Schwartz, TS | 1 |
Baker, BA | 1 |
Toedebusch, RG | 1 |
Childs, TE | 1 |
Booth, FW | 1 |
Roberts, MD | 1 |
França, AP | 1 |
Schamne, MG | 1 |
de Souza, BS | 1 |
da Luz Scheffer, D | 1 |
Bernardelli, AK | 1 |
Corrêa, T | 1 |
de Souza Izídio, G | 1 |
Latini, A | 1 |
da Silva-Santos, JE | 1 |
Canas, PM | 1 |
Cunha, RA | 2 |
Prediger, RD | 2 |
Martínez-Rodríguez, A | 1 |
Cuestas-Calero, BJ | 1 |
Hernández-García, M | 1 |
Martíez-Olcina, M | 1 |
Vicente-Martínez, M | 1 |
Rubio-Arias, JÁ | 1 |
Min, H | 1 |
Youn, E | 1 |
Shim, YH | 1 |
Tallis, J | 1 |
James, RS | 1 |
Cox, VM | 1 |
Duncan, MJ | 1 |
Watanabe, S | 1 |
Takahashi, T | 1 |
Ogawa, H | 1 |
Uehara, H | 1 |
Tsunematsu, T | 1 |
Baba, H | 1 |
Morimoto, Y | 1 |
Tsuneyama, K | 1 |
Takahashi, K | 2 |
Yanai, S | 1 |
Shimokado, K | 1 |
Ishigami, A | 2 |
Verster, JC | 1 |
Koenig, J | 1 |
Toda, A | 1 |
Uehara, S | 1 |
Inoue, T | 1 |
Utoh, M | 1 |
Kusama, T | 1 |
Shimizu, M | 1 |
Uno, Y | 1 |
Mogi, M | 1 |
Sasaki, E | 1 |
Yamazaki, H | 1 |
Bakris, GL | 1 |
Orbán, C | 1 |
Vásárhelyi, Z | 1 |
Bajnok, A | 1 |
Sava, F | 1 |
Toldi, G | 1 |
da Silva Gonçalves, B | 1 |
Leal-Rocha, PH | 1 |
Manhães, AC | 1 |
Filgueiras, CC | 1 |
Abreu-Villaça, Y | 1 |
Ribeiro-Carvalho, A | 1 |
Garcez, ML | 1 |
Damiani, AP | 1 |
Pacheco, R | 1 |
Rodrigues, L | 1 |
de Abreu, LL | 1 |
Alves, MC | 1 |
de Andrade, VM | 1 |
Boeck, CR | 1 |
Vercambre, MN | 1 |
Berr, C | 1 |
Ritchie, K | 1 |
Kang, JH | 2 |
Rallis, C | 1 |
Bähler, J | 1 |
Tchekalarova, J | 2 |
Kubová, H | 3 |
Mareš, P | 3 |
Silva, CG | 1 |
Métin, C | 1 |
Fazeli, W | 1 |
Machado, NJ | 1 |
Darmopil, S | 1 |
Launay, PS | 1 |
Ghestem, A | 1 |
Nesa, MP | 1 |
Bassot, E | 1 |
Szabó, E | 1 |
Baqi, Y | 2 |
Müller, CE | 2 |
Tomé, AR | 1 |
Ivanov, A | 1 |
Isbrandt, D | 1 |
Zilberter, Y | 1 |
Esclapez, M | 1 |
Bernard, C | 1 |
Tchekalarova, JD | 1 |
Cechella, JL | 2 |
Leite, MR | 4 |
Dobrachinski, F | 2 |
da Rocha, JT | 2 |
Carvalho, NR | 1 |
Duarte, MM | 1 |
Soares, FA | 2 |
Bresciani, G | 2 |
Royes, LF | 2 |
Zeni, G | 3 |
Marcondes Sari, MH | 1 |
de Freitas, ML | 1 |
Oliveira, LP | 1 |
Dalmolin, L | 1 |
Brandão, R | 2 |
Carman, AJ | 1 |
Dacks, PA | 1 |
Lane, RF | 1 |
Shineman, DW | 1 |
Fillit, HM | 1 |
Mennella, JA | 1 |
Reed, DR | 1 |
Roberts, KM | 1 |
Mathew, PS | 1 |
Mansfield, CJ | 1 |
Gai, BM | 1 |
Jiang, H | 1 |
Wang, C | 1 |
Guan, J | 1 |
Wang, L | 1 |
Li, Z | 1 |
Lamboley, CR | 1 |
Wyckelsma, VL | 1 |
Dutka, TL | 1 |
McKenna, MJ | 1 |
Murphy, RM | 1 |
Lamb, GD | 1 |
Poole, RL | 1 |
Braak, D | 1 |
Gould, TJ | 1 |
Cutler, RG | 1 |
Camandola, S | 1 |
Malott, KF | 1 |
Edelhauser, MA | 1 |
Mattson, MP | 1 |
Ullah, F | 1 |
Ali, T | 1 |
Ullah, N | 1 |
Kim, MO | 1 |
Solfrizzi, V | 1 |
Panza, F | 1 |
Imbimbo, BP | 1 |
D'Introno, A | 1 |
Galluzzo, L | 1 |
Gandin, C | 1 |
Misciagna, G | 1 |
Guerra, V | 1 |
Osella, A | 1 |
Baldereschi, M | 1 |
Di Carlo, A | 1 |
Inzitari, D | 1 |
Seripa, D | 1 |
Pilotto, A | 1 |
Sabbá, C | 1 |
Logroscino, G | 1 |
Scafato, E | 1 |
Frau, L | 1 |
Costa, G | 1 |
Porceddu, PF | 1 |
Khairnar, A | 1 |
Castelli, MP | 1 |
Ennas, MG | 1 |
Madeddu, C | 1 |
Wardas, J | 1 |
Morelli, M | 1 |
Doty, RL | 1 |
Heidt, JM | 1 |
MacGillivray, MR | 1 |
Dsouza, M | 1 |
Tracey, EH | 1 |
Mirza, N | 1 |
Bigelow, D | 1 |
O'Neill, CE | 1 |
Newsom, RJ | 1 |
Stafford, J | 1 |
Scott, T | 1 |
Archuleta, S | 1 |
Levis, SC | 1 |
Spencer, RL | 1 |
Campeau, S | 1 |
Bachtell, RK | 1 |
Dance, A | 1 |
Batalha, VL | 2 |
Ferreira, DG | 1 |
Coelho, JE | 1 |
Valadas, JS | 1 |
Gomes, R | 1 |
Temido-Ferreira, M | 1 |
Shmidt, T | 1 |
Buée, L | 1 |
Hamdane, M | 1 |
Outeiro, TF | 2 |
Bader, M | 1 |
Meijsing, SH | 1 |
Sadri-Vakili, G | 1 |
Blum, D | 1 |
Lopes, LV | 2 |
Chauhan, G | 1 |
Ray, K | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Pilot, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Effectiveness and Safety of an Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health Among [NCT05170113] | 79 participants (Actual) | Interventional | 2021-11-02 | Completed | |||
A Pilot Study of Facial Recognition Software to Assess Palatability in Pediatric Patients[NCT02923908] | 12 participants (Actual) | Observational | 2016-12-31 | Completed | |||
Efficacy of Bitter Taste Blockers on Flavor Acceptance in Pediatric Populations[NCT01407939] | 215 participants (Actual) | Observational | 2011-04-30 | Completed | |||
Comparison of Synthetic and Natural Caffeine on Hemodynamic Parameters in Young, Healthy Volunteers: A Randomized, Double Blind, Crossover Study[NCT03495063] | 0 participants (Actual) | Interventional | 2019-09-16 | Withdrawn (stopped due to Unable to quantify caffeine) | |||
Residual Immune Activation in HIV-infected Patients on Successful cART: Association Between Inflammasome Activation in Monocytes by Circulating Metabolites and Non AIDS Defining Comorbidities[NCT03191175] | 55 participants (Actual) | Observational | 2017-07-03 | Completed | |||
Immune Senescence in the Elderly: Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages[NCT01827462] | Phase 4 | 136 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
Longitudinal Study to Assess the Effects of Whole Coffee Cherry Extract (WCCE)[NCT04986956] | 323 participants (Actual) | Interventional | 2022-02-01 | Active, not recruiting | |||
Effects of Insulin on Hypotension and Sarcopenia[NCT03248271] | 0 participants (Actual) | Observational | 2017-10-01 | Withdrawn (stopped due to Study design was changed to the study was changed to Insulin, hypotension and sarcopenia.) | |||
Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia[NCT05295784] | Phase 1 | 18 participants (Anticipated) | Interventional | 2024-06-30 | Not yet recruiting | ||
CID 0708 - Sex, Aging and Antiretroviral Pharmacokinetics[NCT00666055] | 11 participants (Actual) | Observational | 2008-03-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
(NCT01827462)
Timeframe: Day 0 annually while on study
Intervention | Participants (Count of Participants) |
---|---|
18-30 Years Old at Enrollment | 59 |
60-79 Years Old at Enrollment | 37 |
80-100 Years Old at Enrollment | 40 |
20 reviews available for caffeine and Aging
Article | Year |
---|---|
Effect of Supplements on Endurance Exercise in the Older Population: Systematic Review.
Topics: Aged; Aging; Caffeine; Dietary Supplements; Exercise; Exercise Therapy; Female; Humans; Male; Physic | 2020 |
Caffeine intake and its sources: A review of national representative studies.
Topics: Aging; Beverages; Caffeine; Global Health; Humans | 2018 |
Current evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Animals; Caffeine; Coffee; Cognition; Cognition Disorders; Humans; Memory, | 2014 |
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.
Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobrom | 2015 |
Optimizing natural fertility.
Topics: Aging; Alcohol Drinking; Caffeine; Coitus; Diet; Female; Fertility; Humans; Life Style; Male; Ovulat | 2008 |
Sleep: a good investment in health and safety.
Topics: Age Factors; Aged; Aging; Agriculture; Caffeine; Central Nervous System Stimulants; Fatigue; Female; | 2008 |
Modulating Alzheimer's disease through caffeine: a putative link to epigenetics.
Topics: Adenosine A2 Receptor Antagonists; Aging; Alzheimer Disease; Animals; Caffeine; Epigenesis, Genetic; | 2011 |
Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents.
Topics: Adult; Aging; Caffeine; Environmental Exposure; Half-Life; Humans; Infant, Newborn; Liver; Metabolic | 2004 |
Attention, psychomotor functions and age.
Topics: Aged; Aging; Attention; Caffeine; Cognition; Glucose; Humans; Memory; Mental Processes; Middle Aged; | 2005 |
Orthostatic hypotension in the elderly: diagnosis and treatment.
Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents; Blood Pressure | 2007 |
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; | 1984 |
Age-dependent changes in calcium currents and calcium homeostasis in mammalian neurons.
Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channels; Cells, Cultured; Cerebral Cor | 1994 |
Caffeine and the elderly.
Topics: Aged; Aging; Bone and Bones; Caffeine; Cardiovascular System; Central Nervous System Stimulants; Die | 1998 |
Nutrients, age and cognitive function.
Topics: Aged; Aging; Caffeine; Cognition; Diet; Dietary Supplements; Eating; Ginkgo biloba; Glucose; Humans; | 1998 |
The science and complexity of bitter taste.
Topics: Aging; Caffeine; Eating; Feeding Behavior; Flavoring Agents; Food Preferences; Humans; Perception; T | 2001 |
The role of DNA repair and somatic mutation in carcinogenesis.
Topics: Aging; Base Sequence; Caffeine; Carcinogens; Cell Differentiation; Cell Division; Chromatin; Chromos | 1975 |
DNA repair.
Topics: Aging; Alkylating Agents; Animals; Caffeine; Carcinogens; Deoxyribodipyrimidine Photo-Lyase; DNA; DN | 1977 |
[Recent progress in the pharmacology of learning and memory in China].
Topics: Aging; Caffeine; Learning; Memory; Panax; Plant Extracts; Plants, Medicinal | 1986 |
Contracture and the calcium paradox.
Topics: 2,4-Dinitrophenol; Aging; Animals; Caffeine; Calcium; Dimethyl Sulfoxide; Dinitrophenols; Freeze Fra | 1985 |
Drugs and memory disorders in human aging.
Topics: Adolescent; Adult; Aged; Aging; Amphetamine; Anticonvulsants; Antidepressive Agents; Arousal; Caffei | 1972 |
15 trials available for caffeine and Aging
Article | Year |
---|---|
Caffeine and cognitive decline in elderly women at high vascular risk.
Topics: Aged; Aging; Caffeine; Central Nervous System Stimulants; Cerebrovascular Disorders; Cognition; Cogn | 2013 |
Age-related differences in bitter taste and efficacy of bitter blockers.
Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt | 2014 |
Age-related differences in bitter taste and efficacy of bitter blockers.
Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt | 2014 |
Age-related differences in bitter taste and efficacy of bitter blockers.
Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt | 2014 |
Age-related differences in bitter taste and efficacy of bitter blockers.
Topics: Adult; Aging; Caffeine; Child; Child, Preschool; Female; Genotype; Gluconates; Humans; Male; Propylt | 2014 |
Caffeine intake increases plasma ketones: an acute metabolic study in humans.
Topics: Adult; Aging; Alzheimer Disease; Brain; Caffeine; Dietary Supplements; Dose-Response Relationship, D | 2017 |
Caffeine impairs myocardial blood flow response to physical exercise in patients with coronary artery disease as well as in age-matched controls.
Topics: Aging; Caffeine; Case-Control Studies; Coronary Artery Disease; Coronary Circulation; Exercise; Fema | 2009 |
The effect of caffeine on working memory load-related brain activation in middle-aged males.
Topics: Adult; Aging; Attention; Caffeine; Central Nervous System Stimulants; Coffee; Cross-Over Studies; Do | 2013 |
Challenging sleep in aging: the effects of 200 mg of caffeine during the evening in young and middle-aged moderate caffeine consumers.
Topics: Adult; Aged; Aging; Beverages; Caffeine; Circadian Rhythm; Coffee; Cross-Over Studies; Double-Blind | 2006 |
Aging, caffeine, and information processing: an event-related potential analysis.
Topics: Adolescent; Adult; Aged; Aging; Caffeine; Electroencephalography; Evoked Potentials, Auditory; Femal | 1995 |
Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Body Temperature; Caffeine; Carbon Radioisotop | 1995 |
Interactions between dietary caffeine and calcium on calcium and bone metabolism in older women.
Topics: Adult; Aged; Aging; Alkaline Phosphatase; Bone and Bones; Caffeine; Calcium; Calcium, Dietary; Creat | 1994 |
Acute effects of fructose and glucose ingestion with and without caffeine in young and old humans.
Topics: Adult; Aged; Aging; Alanine; Analysis of Variance; Blood Glucose; Body Temperature Regulation; Caffe | 1995 |
Influence of age, frailty and liver function on the pharmacokinetics of brofaromine.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Caffeine; Chromatography, Gas; Cross-Ov | 1996 |
Relationship of blood pressure, heart rate and behavioral mood state to norepinephrine kinetics in younger and older men following caffeine ingestion.
Topics: Adult; Affect; Aged; Aging; Blood Pressure; Body Composition; Caffeine; Double-Blind Method; Heart R | 1998 |
The effects of age on the response to caffeine.
Topics: Adolescent; Adult; Aged; Aging; Attention; Caffeine; Female; Flicker Fusion; Humans; Male; Postural | 1988 |
Comparison of the urinary metabolite profile of caffeine in young and elderly males.
Topics: Adult; Aged; Aging; Caffeine; Glomerular Filtration Rate; Humans; Male; Random Allocation; Theobromi | 1985 |
Effect of maternal caffeine consumption on heart rate and sleep time of breast-fed infants.
Topics: Aging; Breast Feeding; Caffeine; Double-Blind Method; Female; Heart Rate; Humans; Infant; Infant, Ne | 1985 |
180 other studies available for caffeine and Aging
Article | Year |
---|---|
Sleep Disorders and Future Diagnosis of Parkinsonism: A Prospective Study Using the Canadian Longitudinal Study on Aging.
Topics: Aged; Aging; Caffeine; Canada; Disorders of Excessive Somnolence; Humans; Longitudinal Studies; Male | 2022 |
Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats.
Topics: Aging; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Caffeine; Chromatin; Chro | 2019 |
Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder.
Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Brain; Brain-Derive | 2020 |
Long-Term Caffeine Intake Exerts Protective Effects on Intestinal Aging by Regulating Vitellogenesis and Mitochondrial Function in an Aged
Topics: Actins; Aging; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caffeine; Intestines; | 2021 |
Is the Ergogenicity of Caffeine Affected by Increasing Age? The Direct Effect of a Physiological Concentration of Caffeine on the Power Output of Maximally Stimulated EDL and Diaphragm Muscle Isolated from the Mouse.
Topics: Aging; Animals; Caffeine; Diaphragm; Female; Mice; Muscle Contraction; Muscle Fatigue; Performance-E | 2017 |
Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice.
Topics: Aging; Animals; Caffeine; Coffee; Diabetes Mellitus, Type 2; Hyperlipidemias; Insulin-Secreting Cell | 2017 |
Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels.
Topics: Aging; Animals; Caffeine; Coffee; Energy Metabolism; Lipid Metabolism; Liver; Male; Mice; Mice, Inbr | 2017 |
Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19.
Topics: Administration, Intravenous; Aging; Animals; Caffeine; Callithrix; Cytochrome P-450 CYP2C19; Genotyp | 2018 |
Anti-aging effects of coffee.
Topics: Aged; Aged, 80 and over; Aging; Animals; Caffeine; Coffee; Functional Food; Humans; Lipid Metabolism | 2017 |
MY APPROACH to the elderly patient with resistant hypertension.
Topics: Age Factors; Aging; Antihypertensive Agents; Blood Pressure; Caffeine; Central Nervous System Stimul | 2018 |
Effects of caffeine and phosphodiesterase inhibitors on activation of neonatal T lymphocytes.
Topics: Adenosine A2 Receptor Antagonists; Adult; Aging; Caffeine; Calcium Signaling; Cells, Cultured; Cycli | 2018 |
Lifelong exposure to caffeine increases anxiety-like behavior in adult mice exposed to tobacco smoke during adolescence.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Caffeine; Cotinine; Exploratory Behavior; Female; Male; M | 2019 |
Caffeine Neuroprotection Decreases A2A Adenosine Receptor Content in Aged Mice.
Topics: Adenosine A2 Receptor Antagonists; Aging; Animals; Caffeine; Cell Survival; Hippocampus; Male; Mice; | 2019 |
Inhibition of TORC1 signaling and increased lifespan: gained in translation?
Topics: Aging; Animals; Antifungal Agents; Caffeine; Caloric Restriction; Mechanistic Target of Rapamycin Co | 2013 |
Effects of caffeine on cortical epileptic afterdischarges in adult rats are modulated by postnatal treatment.
Topics: Aging; Animals; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Disease Models, Animal | 2013 |
Adenosine receptor antagonists including caffeine alter fetal brain development in mice.
Topics: Aging; Animals; Animals, Newborn; Brain; Caffeine; Cell Movement; Cognition Disorders; Disease Susce | 2013 |
Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood.
Topics: Aging; Animals; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Myoc | 2013 |
Moderate swimming exercise and caffeine supplementation reduce the levels of inflammatory cytokines without causing oxidative stress in tissues of middle-aged rats.
Topics: Aging; Animals; Caffeine; Cytokines; Dietary Supplements; Exercise Therapy; Humans; Inflammation; Li | 2014 |
Caffeine and diphenyl diselenide improve long-term memory impaired in middle-aged rats.
Topics: Aging; Animals; Benzene Derivatives; Caffeine; CREB-Binding Protein; Dietary Supplements; Drug Evalu | 2014 |
Caffeine suppresses exercise-enhanced long-term and location memory in middle-aged rats: Involvement of hippocampal Akt and CREB signaling.
Topics: Aging; Animals; Caffeine; Cyclic AMP Response Element-Binding Protein; Glutamic Acid; Hippocampus; M | 2014 |
Changes of spontaneous parthenogenetic activation and development potential of golden hamster oocytes during the aging process.
Topics: Aging; Animals; Caffeine; Cells, Cultured; Cricetinae; Cumulus Cells; Female; Histone Deacetylase In | 2015 |
Contractile properties and sarcoplasmic reticulum calcium content in type I and type II skeletal muscle fibres in active aged humans.
Topics: Adult; Aged; Aging; Caffeine; Calcium; Female; Humans; In Vitro Techniques; Magnesium; Male; Muscle | 2015 |
Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice.
Topics: Aging; Animals; Anxiety; Caffeine; Central Nervous System Stimulants; Conditioning, Psychological; D | 2016 |
Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain.
Topics: Aging; Animals; Antioxidants; Brain; Caffeine; Cognition Disorders; Disease Models, Animal; Galactos | 2015 |
Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging.
Topics: Aged; Aged, 80 and over; Aging; Caffeine; Coffee; Cognitive Dysfunction; Depression; Feeding Behavio | 2015 |
Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent.
Topics: Age Factors; Aging; Animals; Caffeine; Dopaminergic Neurons; Drug Synergism; Inflammation; Male; Mic | 2016 |
Influences of age, tongue region, and chorda tympani nerve sectioning on signal detection measures of lingual taste sensitivity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Caffeine; Chorda Tympani Nerve; Dietary Sucrose; | 2016 |
Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling.
Topics: Adrenocorticotropic Hormone; Aging; Amygdala; Animals; Anxiety; Behavior, Animal; Caffeine; Corticos | 2016 |
Smart drugs: A dose of intelligence.
Topics: Aging; Amphetamines; Animals; Benzhydryl Compounds; Biomedical Enhancement; Caffeine; Child; Cogniti | 2016 |
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
Topics: Aging; Animals; Caffeine; Cell Nucleus; Cognitive Dysfunction; Corticosterone; Humans; Hypothalamo-H | 2016 |
Adenosine A1 receptor antagonist mitigates deleterious effects of sleep deprivation on adult neurogenesis and spatial reference memory in rats.
Topics: Adenosine A1 Receptor Antagonists; Aging; Animals; Caffeine; Doublecortin Protein; Hippocampus; Male | 2016 |
Caffeine Use among Active Duty Navy and Marine Corps Personnel.
Topics: Adolescent; Adult; Aging; Beverages; Caffeine; Cross-Sectional Studies; Data Collection; Female; Hum | 2016 |
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine; | 2017 |
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine; | 2017 |
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine; | 2017 |
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine; | 2017 |
Protection of brain and pancreas from high-fat diet: effects of catechin and caffeine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Body Weight; Brain; Caffeine; Catechin; Central Nervous | 2009 |
Advancing age alters the contribution of calcium release from smooth endoplasmic reticulum stores in superior cervical ganglion cells.
Topics: Aging; Animals; Caffeine; Calcium; Electric Stimulation; Endoplasmic Reticulum; Intracellular Fluid; | 2009 |
The effect of recent consumption of caffeine-containing foodstuffs on neuropsychological tests in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Caffeine; Central Nervous System Stimulants; Cognition; Female; Food | 2009 |
Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice.
Topics: Aging; Animals; Arrhythmias, Cardiac; Caffeine; Calcium Signaling; Calcium-Binding Proteins; Disease | 2009 |
Effect of beer drinking on ultrasound bone mass in women.
Topics: Adult; Aging; Alcohol Drinking; Analysis of Variance; Beer; Body Mass Index; Bone Density; Caffeine; | 2009 |
Prevalence and distribution of fasciculations in healthy adults: Effect of age, caffeine consumption and exercise.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Aging; Beverages; Caffeine; Central Nervous System | 2010 |
Maturation and long-term hypoxia alters Ca2+-induced Ca2+ release in sheep cerebrovascular sympathetic neurons.
Topics: Age Factors; Aging; Animals; Caffeine; Calcium; Calcium Signaling; Cerebral Arteries; Cyclic ADP-Rib | 2009 |
Caffeine consumption and cognitive function at age 70: the Lothian Birth Cohort 1936 study.
Topics: Aged; Aging; Caffeine; Child; Coffee; Cognition; Cognition Disorders; Cohort Studies; Drinking Behav | 2010 |
Developmental aspects of cardiac Ca(2+) signaling: interplay between RyR- and IP(3)R-gated Ca(2+) stores.
Topics: Adenosine Triphosphate; Aging; Animals; Boron Compounds; Caffeine; Calcium; Calcium Channel Blockers | 2010 |
Age-related functional changes in gustatory and reward processing regions: An fMRI study.
Topics: Adult; Aged; Aging; Brain; Brain Mapping; Caffeine; Central Nervous System Stimulants; Citric Acid; | 2010 |
Caffeine attenuates lipopolysaccharide-induced neuroinflammation.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aging; Animals; Caffeine; Chro | 2010 |
Risk factors of osteoporosis in healthy Moroccan men.
Topics: Absorptiometry, Photon; Adult; Age Distribution; Aged; Aging; Body Mass Index; Body Weight; Bone Dis | 2010 |
Postnatal period of caffeine treatment and time of testing modulate the effect of acute caffeine on cortical epileptic afterdischarges in rats.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Anticonvulsants; Caffeine; Cerebral Cortex; Con | 2010 |
Protective effect of caffeine and a selective A2A receptor antagonist on impairment of memory and oxidative stress of aged rats.
Topics: Adenosine A2 Receptor Antagonists; Aging; Animals; Ascorbic Acid; Brain; Caffeine; Male; Memory; Mem | 2011 |
Comparison of caffeine-induced locomotor activity between adolescent and adult rats.
Topics: Aging; Animals; Caffeine; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Male; Mo | 2011 |
Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.
Topics: Aging; Anilides; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Sig | 2011 |
Overexpression of type 1 angiotensin II receptors impairs excitation-contraction coupling in the mouse heart.
Topics: Age Factors; Aging; Animals; Blotting, Western; Caffeine; Calcium Channels, L-Type; Calcium Signalin | 2011 |
Chronic caffeine consumption prevents cognitive decline from young to middle age in rats, and is associated with increased length, branching, and spine density of basal dendrites in CA1 hippocampal neurons.
Topics: Aging; Animals; Anxiety; CA1 Region, Hippocampal; Caffeine; Central Nervous System Stimulants; Cogni | 2012 |
Oxidative phosphorylation-linked respiration in individual bovine oocytes.
Topics: Adenosine Triphosphate; Aging; Animals; Caffeine; Cattle; Cell Respiration; Female; Mitochondria; Oo | 2012 |
Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats.
Topics: Aging; Animals; Avoidance Learning; Behavior, Animal; Brain-Derived Neurotrophic Factor; Caffeine; C | 2013 |
Predicted metabolic drug clearance with increasing adult age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; M | 2013 |
Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Blood Glucose; Blotting, Western; Caffeine; Diabetes | 2013 |
Can age-related CNS taste differences be detected as early as middle age? Evidence from fMRI.
Topics: Adult; Aging; Analysis of Variance; Body Mass Index; Brain; Brain Mapping; Caffeine; Dietary Sucrose | 2013 |
Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups.
Topics: Aging; Animals; Animals, Newborn; Apnea; Body Temperature; Caffeine; Central Nervous System Stimulan | 2013 |
Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging.
Topics: Aging; Animals; Behavior, Animal; Beverages; Caffeine; Central Nervous System Stimulants; Coffee; Co | 2013 |
Excitation-contraction coupling and sarcoplasmic reticulum function in mechanically skinned fibres from fast skeletal muscles of aged mice.
Topics: Aging; Animals; Caffeine; Calcium; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbre | 2002 |
Decreased sensitivity of neonatal rabbit sarcoplasmic reticulum to anthracycline cardiotoxicity.
Topics: Aging; Animals; Animals, Newborn; Antibiotics, Antineoplastic; Caffeine; Daunorubicin; Doxorubicin; | 2002 |
Alterations by age of calcium handling in rat resistance arteries.
Topics: Aging; Animals; Caffeine; Calcium; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Phenylephrin | 2002 |
Influence of age and run training on cardiac Na+/Ca2+ exchange.
Topics: Action Potentials; Aging; Animals; Blotting, Western; Caffeine; Calcium; Exercise Test; Male; Myocar | 2003 |
Insulin-like growth factor-1 prevents age-related decrease in specific force and intracellular Ca2+ in single intact muscle fibres from transgenic mice.
Topics: Aging; Anatomy, Cross-Sectional; Animals; Caffeine; Calcium; Extremities; Humans; Insulin-Like Growt | 2003 |
The effects of habitual caffeine use on cognitive change: a longitudinal perspective.
Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Chi-Square Distribution; Cognition; Feeding Behavio | 2003 |
Age-dependent emergence of oscillatory signal flow between the primary and secondary visual cortices in rat brain slices.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Caffeine; Calcium; Electric Stimulation; Electrophysiol | 2003 |
Effects of acute bouts of running and swimming exercise on PGC-1alpha protein expression in rat epitrochlearis and soleus muscle.
Topics: Aging; Aminoimidazole Carboxamide; Animals; Caffeine; Forelimb; Glycogen; Male; Muscle, Skeletal; Pr | 2004 |
Age-dependent emergence of a parieto-insular corticocortical signal flow in developing rats.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Caffeine; Central Nervous System Stim | 2004 |
Reduced mitochondrial buffering of voltage-gated calcium influx in aged rat basal forebrain neurons.
Topics: Aging; Animals; Buffers; Caffeine; Calcium; Calcium Channels; In Vitro Techniques; Kinetics; Male; M | 2004 |
Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin.
Topics: Aging; Animals; Atrial Function; Caffeine; Calcium; Calcium-Binding Proteins; Dogs; Electric Stimula | 2004 |
Effect of concentration on taste-taste interactions in foods for elderly and young subjects.
Topics: Acetic Acid; Adult; Aged; Aging; Caffeine; Female; Food Preservatives; Humans; Male; Middle Aged; Se | 2004 |
Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors.
Topics: Aging; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Discrimination Learni | 2005 |
Advancing age alters rapid and spontaneous refilling of caffeine-sensitive calcium stores in sympathetic superior cervical ganglion cells.
Topics: Aging; Animals; Caffeine; Calcium; Calcium Signaling; Cells, Cultured; Dose-Response Relationship, D | 2005 |
Excessive daytime sleepiness and subsequent development of Parkinson disease.
Topics: Aged; Aged, 80 and over; Aging; Brain; Caffeine; Causality; Cognition Disorders; Cohort Studies; Com | 2005 |
Effects of caffeine treatment on aged porcine oocytes: parthenogenetic activation ability, chromosome condensation and development to the blastocyst stage after somatic cell nuclear transfer.
Topics: Aging; Animals; Blastocyst; Caffeine; Chromatin Assembly and Disassembly; Embryo, Mammalian; Female; | 2005 |
Effects of aging on Ca2+ signaling in murine mesenteric arterial smooth muscle cells.
Topics: Aging; Animals; Barium; Caffeine; Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Membrane | 2006 |
Modulation of neuronal [Ca2+]i by caffeine is altered with aging.
Topics: Aging; Animals; Caffeine; Calcium; Central Nervous System Stimulants; Hippocampus; Male; Mice; Mice, | 2006 |
The effects of male age on sperm DNA damage in healthy non-smokers.
Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Coffee; Comet Assay; DNA Damage; Humans; Life Style | 2007 |
Age-dependent effects on functional aspects in human satellite cells.
Topics: Adenosine Triphosphate; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Caffeine; Calcium; Femal | 2007 |
Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.
Topics: Adult; Aging; Brain Injuries; Caffeine; Central Nervous System Depressants; Central Nervous System S | 2008 |
The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration.
Topics: Aging; Animals; Brain; Caffeine; Environmental Pollutants; Female; Gene Deletion; Lactation; Male; M | 2007 |
The influence of sex and age in albino rats given a daily oral dose of caffeine at a high dose level.
Topics: Adrenal Glands; Aging; Animals; Body Weight; Brain Chemistry; Caffeine; Drinking; Eating; Female; Gl | 1967 |
Caffeine disposition and effects in young and one-year old rats.
Topics: Aging; Animals; Brain Chemistry; Caffeine; Fatty Acids, Nonesterified; Half-Life; In Vitro Technique | 1980 |
Effects of methylxanthines on lipid synthesis in developing neural systems.
Topics: Acetyl-CoA Carboxylase; Aging; Aminophylline; Brain; Caffeine; Cell Division; Cell Line; Cholesterol | 1981 |
Effects of caffeine on the mechanical properties of developing rat heart ventricles.
Topics: Action Potentials; Aging; Animals; Caffeine; Female; Heart; In Vitro Techniques; Male; Myocardial Co | 1984 |
DNA repair in cultured human fibroblasts does not decline with donor age.
Topics: Aged; Aging; Caffeine; Cell Line; Child, Preschool; DNA Repair; DNA, Viral; Fibroblasts; Humans; Inf | 1982 |
Six-hydroxydopamine induced hyperactivity: neither sex differences nor caffeine stimulation are found.
Topics: Aging; alpha-Methyltyrosine; Animals; Body Weight; Brain; Brain Chemistry; Caffeine; Catecholamines; | 1984 |
In vivo and in vitro effects of caffeine on hepatic mixed-function oxidases in rodents and chicks.
Topics: Aging; Animals; Caffeine; Chickens; Cytochromes; Female; Guinea Pigs; In Vitro Techniques; Male; Mic | 1984 |
Free fatty acid levels in habitual coffee drinkers in relation to quantities consumed, sex and age.
Topics: Adult; Aging; Caffeine; Coffee; Drinking Behavior; Fatty Acids, Nonesterified; Female; Humans; Male; | 1983 |
Age-related changes in tetanic contraction of ventricular myocardium.
Topics: Aging; Animals; Caffeine; Calcium; Dogs; In Vitro Techniques; Myocardial Contraction | 1984 |
Nutritional factors and estrogen in age-related bone loss.
Topics: Adult; Aged; Aging; Bone Resorption; Caffeine; Calcium; Calcium, Dietary; Dietary Proteins; Estrogen | 1982 |
Protein binding of caffeine in young and elderly males.
Topics: Adolescent; Adult; Aged; Aging; Blood Proteins; Caffeine; Humans; Male; Membranes; Protein Binding; | 1982 |
Tissue distribution of caffeine in premature infants and in newborn and adult dogs.
Topics: Aging; Animals; Animals, Newborn; Caffeine; Dogs; Humans; Infant; Infant, Newborn; Infant, Premature | 1981 |
[Protective action of hyperbaric oxygenation in acute circulatory disorders in rats of different ages].
Topics: Acoustic Stimulation; Acute Disease; Aging; Animals; Caffeine; Cardiovascular Diseases; Female; Hype | 1980 |
A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain.
Topics: Aging; Aminophylline; Animals; Body Weight; Brain; Caffeine; Intracellular Membranes; Myelin Sheath; | 1981 |
Chronic methylxanthine treatment in rats: a comparison of Wistar and Fischer 344 strains.
Topics: Aging; Aminophylline; Animals; Behavior, Animal; Caffeine; Diet; Rats; Rats, Inbred F344; Sex Factor | 1981 |
Caffeine metabolism in liver slices during postnatal development in the rat.
Topics: Aging; Allopurinol; Animals; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; In V | 1981 |
Age and sex effects on taste of sucrose, NaCl, citric acid and caffeine.
Topics: Adult; Aged; Aging; Caffeine; Citrates; Citric Acid; Discrimination, Psychological; Humans; Sodium C | 1981 |
Contracture responses and energy stores in quadriceps muscle from humans age 7-82 years.
Topics: Adolescent; Adult; Aged; Aging; Caffeine; Child; Energy Metabolism; Halothane; Humans; Middle Aged; | 1980 |
Relationship between the clearance of caffeine and its 7-N-demethylation in developing beagle puppies.
Topics: Aging; Animals; Caffeine; Dealkylation; Dogs; Female; Kinetics; Theobromine; Theophylline; Xanthines | 1980 |
Intracellular Ca2+ stores in chick cerebellum Purkinje neurons: ontogenetic and functional studies.
Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases; | 1995 |
The effect of caffeine on mammary gland development and milk yield in primiparous sows.
Topics: Aging; Animals; Animals, Suckling; Birth Weight; Caffeine; DNA; Eating; Female; Lactation; Mammary G | 1995 |
Effects of age on sarcoplasmic reticulum properties and histochemical composition of fast- and slow-twitch rat muscles.
Topics: Aging; Animals; Body Weight; Caffeine; Calcium; Histocytochemistry; Male; Muscle Fibers, Fast-Twitch | 1995 |
Characterization of Ca(2+)-release channels in fetal and adult rat hearts.
Topics: Aging; Animals; Caffeine; Calcium; Calcium Channels; Fetus; Heart; Heart Ventricles; Kinetics; Myoca | 1995 |
G2 repair and aging: influence of donor age on chromosomal aberrations in human lymphocytes.
Topics: Adenosine; Adult; Aged; Aging; Caffeine; Cell Cycle; Child, Preschool; Chromosome Aberrations; DNA R | 1993 |
Sarcoplasmic reticulum function in newborn ferret cremaster skeletal muscles.
Topics: Adenosine Triphosphatases; Aging; Animals; Animals, Newborn; Caffeine; Calcium; Calcium-Transporting | 1994 |
Effects of neonatal exposure to caffeine on adenosine A1 receptor ontogeny using autoradiography.
Topics: Adenosine; Administration, Oral; Aging; Animals; Animals, Newborn; Autoradiography; Brain; Caffeine; | 1994 |
Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults.
Topics: Adult; Aging; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CY | 1994 |
Intracellular calcium transients from newborn rat cardiomyocytes in primary culture.
Topics: Aging; Animals; Animals, Newborn; Biological Transport; Caffeine; Calcium; Cell Differentiation; Cel | 1994 |
Are there any differences in the excitation-contraction coupling of the working myocardium of adult and newborn guinea-pigs?
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Caffeine; Calcium; Electrophysiology; Guinea Pi | 1993 |
Effects of chronic caffeine feeding on the activities of oxygen free radical defense enzymes in the growing rat heart and liver.
Topics: Aging; Animals; Caffeine; Catalase; Copper; Female; Glutathione Peroxidase; Heart; Iron; Liver; Myoc | 1994 |
Alterations in theophylline metabolism during the first year of life.
Topics: Aging; Analysis of Variance; Caffeine; Humans; Infant; Infant, Newborn; Linear Models; Metabolic Cle | 1993 |
Effect of caffeine and high potassium on normal and dystrophic mouse EDL muscles at various developmental stages.
Topics: Aging; Analysis of Variance; Animals; Caffeine; Calcium; Disease Models, Animal; Female; In Vitro Te | 1993 |
Neonatal caffeine exposure alters seizure susceptibility in rats in an age-related manner.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Convulsants; Disease Susceptibilit | 1995 |
Age-related abnormalities in regulation of the ryanodine receptor in rat fast-twitch muscle.
Topics: Aging; Animals; Antibiotics, Antineoplastic; Binding Sites; Caffeine; Calcium; Calcium Channel Block | 1996 |
Calcium homeostasis in aged neurones.
Topics: Aging; Animals; Caffeine; Calcium; Cells, Cultured; Homeostasis; In Vitro Techniques; Male; Membrane | 1996 |
Effects of caffeine and cyclopiazonic acid on contractile proteins of adult and newborn ferret cardiac fibres.
Topics: Aging; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Caffeine; Calcium; Contractile Proteins; F | 1996 |
Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Caffeine; Estradiol; Estrone; Female; H | 1996 |
Health and dietary characteristics of supplement users in an elderly population.
Topics: Aged; Aged, 80 and over; Aging; Alcohol Drinking; Ascorbic Acid; Caffeine; Calcium, Dietary; Cardiov | 1997 |
Nerve growth factor maintains regulation of intracellular calcium in neonatal sympathetic neurons but not in mature or aged neurons.
Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Cells, Cultured; Central Nervous System Stimula | 1998 |
Developmental changes in purinergic calcium signalling in rat neocortical neurones.
Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium Channels; Calcium Signaling; Cell Membrane; Cere | 1998 |
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 En | 1998 |
Effects of caffeine on the bones of aged, ovariectomized rats.
Topics: Aging; Animals; Body Weight; Bone and Bones; Bone Density; Caffeine; Central Nervous System Stimulan | 1999 |
Age-related alterations in caffeine-sensitive calcium stores and mitochondrial buffering in rat basal forebrain.
Topics: Aging; Animals; Caffeine; Calcium; Fluorescent Dyes; Fura-2; Homeostasis; Male; Mitochondria; Neuron | 1999 |
Effect of age and smoking on in vivo CYP1A2, flavin-containing monooxygenase, and xanthine oxidase activities in Koreans: determination by caffeine metabolism.
Topics: Adult; Aged; Aging; Asian People; Caffeine; Case-Control Studies; Chromatography, High Pressure Liqu | 2000 |
Fetal rabbit pulmonary artery smooth muscle cell response to ryanodine is developmentally regulated.
Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Cells, Cultured; Embryonic and Fetal Developmen | 2000 |
Ignition of calcium sparks in arterial and cardiac muscle through caveolae.
Topics: Aging; Animals; Animals, Newborn; beta-Cyclodextrins; Caffeine; Calcium; Calcium Channels, L-Type; C | 2000 |
Age, fatigue, and excitation-contraction coupling in masseter muscles of rats.
Topics: Aging; Animals; Caffeine; Diet; Hydrogen-Ion Concentration; Male; Masseter Muscle; Muscle Contractio | 2001 |
Response to caffeine and ryanodine receptor isoforms in mouse skeletal muscles.
Topics: Aging; Animals; Animals, Newborn; Caffeine; Diaphragm; Hindlimb; In Vitro Techniques; Mice; Mice, Kn | 2001 |
Application of the PKCYP-test in cases of altered CYP1A2 for multiple CYP systems in rat models of disease.
Topics: Acetanilides; Aging; Algorithms; Animals; Antibodies, Blocking; Caffeine; Central Nervous System Sti | 2001 |
Detailed characterization of experimentally derived human hepatic CYP1A1 activity and expression using differential inhibition of ethoxyresorufin O-deethylation by fluvoxamine.
Topics: Aging; Caffeine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Enzyme Inhibitors; Fluvoxamine; H | 2001 |
Changes in contractile properties of skeletal muscle during developmentally programmed atrophy and death.
Topics: Aging; Animals; Apoptosis; Caffeine; Electric Stimulation; In Vitro Techniques; Larva; Manduca; Memb | 2002 |
[The correlations between aging and drug effects (author's transl)].
Topics: Age Factors; Aging; Animals; Caffeine; Cysteamine; Energy Metabolism; Glycolysis; Hepatectomy; Human | 1976 |
The age-dependent effect of caffeine on the plasma noradrenaline content in white mice.
Topics: Aging; Animals; Caffeine; Calcium; Mice; Norepinephrine; Receptors, Adrenergic, beta; Receptors, Dru | 1978 |
Four stimulants of the central nervous system: effects on short-term memory in young versus aged monkeys.
Topics: Aging; Animals; Caffeine; Central Nervous System Stimulants; Female; Haplorhini; Macaca mulatta; Mal | 1979 |
Changes in free amino acid level due to physical and chemical agents in ageing Drosophila.
Topics: Aging; Amino Acids; Animals; Caffeine; Drosophila melanogaster; Female; Male; Sex Factors | 1979 |
Caffeine metabolism in the newborn.
Topics: Adult; Aging; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Humans; Infant; Inf | 1979 |
Maturation of caffeine elimination in infancy.
Topics: Adult; Aging; Caffeine; Half-Life; Humans; Infant; Infant, Newborn; Kinetics; Metabolic Clearance Ra | 1979 |
The effects of age and illumination on the dose-response curves for three stimulants.
Topics: Adaptation, Psychological; Aging; Animals; Arousal; Caffeine; Darkness; Dextroamphetamine; Dose-Resp | 1975 |
Antipyrine metabolism in man: influence of age, alcohol, caffeine, and smoking.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Alcohol Drinking; Antipyrine; Body Water; Caffeine; Cof | 1975 |
Enhanced spontaneous calcium efflux and decrease of calcium-dependent calcium release from the isolated perfused heart of spontaneously hypertensive rats.
Topics: Aging; Animals; Caffeine; Calcium; Calcium Radioisotopes; Egtazic Acid; Half-Life; Heart; Hypertensi | 1992 |
Effect of caffeine on expression of cardiac myosin heavy chain gene in adult hypothyroid and fetal rats.
Topics: Aging; Animals; Caffeine; Cyclic AMP; Fetal Heart; Fetus; Gene Expression; Hypothyroidism; Myocardiu | 1992 |
Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities.
Topics: Adolescent; Adult; Aging; Analysis of Variance; Arylamine N-Acetyltransferase; Caffeine; Child; Chil | 1992 |
Calcium binding to the cytosol and calcium extrusion mechanisms in intact synaptosomes and their alterations with aging.
Topics: Aging; Animals; Biological Transport; Caffeine; Calcium; Calcium-Transporting ATPases; Carbonyl Cyan | 1992 |
Moderate and severe reactions in blood donors.
Topics: Adjustment Disorders; Adult; Aging; Blood Donors; Body Weight; Caffeine; Female; Humans; Male | 1992 |
Pharmacogenetics of caffeine and caffeine-halothane contractures in biopsies of human skeletal muscle.
Topics: Adolescent; Adult; Aged; Aging; Caffeine; Child; Child, Preschool; Female; Genetic Variation; Haloth | 1991 |
Plasma immunoreactive endothelin-1 in experimental malignant hypertension.
Topics: Aging; Analysis of Variance; Angiotensin II; Animals; Blood Pressure; Blood Urea Nitrogen; Body Weig | 1991 |
A mechanism for relief of replication blocks by activation of unused origins and age-dependent change in the caffeine susceptibility in xeroderma pigmentosum variant.
Topics: Adult; Aging; Caffeine; Cell Survival; Cells, Cultured; Child; DNA Repair; DNA Replication; Drug Res | 1991 |
Contractile responses of rat aorta to phenylephrine and serotonin, and aging.
Topics: Aging; Animals; Aorta, Thoracic; Caffeine; Calcium; Fura-2; In Vitro Techniques; Isometric Contracti | 1991 |
Urinary zinc excretion in infancy.
Topics: Aging; Caffeine; Fetus; Humans; Infant Food; Infant, Newborn; Male; Milk, Human; Reproducibility of | 1990 |
Sex-and age-dependent effects of prenatal exposure to caffeine on open-field behavior, emergence latency and adrenal weights in rats.
Topics: Adrenal Glands; Aging; Animals; Behavior, Animal; Caffeine; Exploratory Behavior; Female; Male; Moto | 1990 |
Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine.
Topics: Adipose Tissue, Brown; Aging; Animals; Body Temperature; Caffeine; Complement Factor D; Drug Combina | 1990 |
Effects of uric acid and caffeine on A1 adenosine receptor binding in developing rat brain.
Topics: Adenosine; Aging; Animals; Binding, Competitive; Brain; Caffeine; Male; Oxonic Acid; Rats; Rats, Inb | 1990 |
Age influences responses of rat isolated aorta and pulmonary artery to the calcium channel agonist, Bay K 8664, and to potassium and calcium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |
Aging is associated with increased Weber ratios for caffeine, but not for sucrose.
Topics: Adolescent; Adult; Aged; Aging; Caffeine; Differential Threshold; Female; Humans; Sucrose; Taste; Ta | 1989 |
The effect of aging on percutaneous absorption in man.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents; Aspirin; B | 1989 |
Increased frequency of spontaneous and X-ray-induced chromosomal aberrations in lymphocytes from neonates and the influence of caffeine--an in vitro study.
Topics: Adult; Aging; Caffeine; Cells, Cultured; Chromosome Aberrations; Gestational Age; Humans; Infant, Ne | 1989 |
Self-report reliability and symptomatology of habitual caffeine consumption.
Topics: Adolescent; Adult; Aging; Alcohol Drinking; Caffeine; Diet; Female; Humans; Male; Research Design; S | 1989 |
Aging and chemosensory perception of and preference for nutritionally significant stimuli.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Blood Chemical Analysis; Caffeine; Caseins; Diet; | 1989 |
Use of flavor-amplified foods to improve nutritional status in elderly patients.
Topics: Aged; Aging; Amiloride; Bretylium Tosylate; Caffeine; Flavoring Agents; Humans; Inosine; Inosine Mon | 1989 |
Comparison of the effects of halothane on skinned myocardial fibers from newborn and adult rabbit: II. Effects on sarcoplasmic reticulum.
Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Halothane; Heart; In Vitro Techniques; Male; My | 1989 |
Age-related changes of action potential plateau shape in isolated human atrial fibers.
Topics: 4-Aminopyridine; Action Potentials; Adult; Aged; Aging; Aminopyridines; Atrial Function; Caffeine; H | 1985 |
The effect of age, gender, and sexual maturation on the caffeine breath test.
Topics: Adolescent; Adult; Age Factors; Aging; Breath Tests; Caffeine; Carbon Dioxide; Child; Child, Prescho | 1986 |
Premenopausal bone mineral content relates to height, weight and calcium intake during early adulthood.
Topics: Adult; Aging; Body Height; Body Weight; Bone and Bones; Caffeine; Calcium, Dietary; Contraceptives, | 1988 |
Developmental changes of caffeine elimination in infancy.
Topics: Aging; Apnea; Caffeine; Drug Administration Schedule; Gestational Age; Half-Life; Humans; Infant; In | 1988 |
Purinergic modulation of cortical acetylcholine release is decreased in aging rats.
Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aging; Animals; Caffeine; Dose-Response | 1988 |
Age, fiber type composition and in vitro contracture responses in human malignant hyperthermia.
Topics: Adolescent; Adult; Aging; Caffeine; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; | 1988 |
The effects of ageing on aminopyrine and caffeine breath tests in the rat.
Topics: Aging; Aminopyrine; Animals; Breath Tests; Caffeine; Female; Half-Life; Longitudinal Studies; Male; | 1987 |
Differential effect of caffeine administration on calcium and vitamin D metabolism in young and adult rats.
Topics: Aging; Animals; Body Weight; Caffeine; Calcitriol; Calcium; Disease Models, Animal; Eating; Feces; I | 1986 |
Rapid high-performance liquid chromatography assay for salivary and serum caffeine following an oral load. An indicator of liver function.
Topics: Adult; Aging; Caffeine; Child; Chromatography, High Pressure Liquid; Half-Life; Humans; Indicators a | 1987 |
The role of the sarcoplasmic reticulum in the response of ferret and rat heart muscle to acidosis.
Topics: Acidosis; Aequorin; Aging; Ammonium Chloride; Animals; Caffeine; Calcium; Ferrets; Hydrogen-Ion Conc | 1987 |
Quantitative liver function in the elderly assessed by galactose elimination capacity, aminopyrine demethylation and caffeine clearance.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aminopyrine; Breath Tests; Caffeine; Female; Galactose; Human | 1986 |
Behavioral effects of prenatal exposure to caffeine in rats.
Topics: Aging; Animals; Behavior, Animal; Caffeine; Emotions; Female; Male; Motor Activity; Pregnancy; Prena | 1986 |
The development of benign prostatic hyperplasia among volunteers in the Normative Aging Study.
Topics: Adult; Aged; Aging; Alcohol Drinking; Blood Glucose; Blood Pressure; Boston; Caffeine; Humans; Hyper | 1985 |
Maturational changes of caffeine concentrations and disposition in infancy during maintenance therapy for apnea of prematurity: influence of gestational age, hepatic disease, and breast-feeding.
Topics: Aging; Apnea; Breast Feeding; Caffeine; Cholestasis; Citrates; Drug Combinations; Gestational Age; H | 1985 |
[Elimination of caffeine and metamizol in in vivo characterization of cytochrome P-450 dependent biotransformation reactions in aged humans].
Topics: Aged; Aging; Aminopyrine; Biotransformation; Caffeine; Creatinine; Cytochrome P-450 Enzyme System; D | 1985 |
Age-correlated effects of caffeine on non-irradiated and UV-irradiated Paramecium Aurelia.
Topics: Aging; Autoradiography; Caffeine; Cell Survival; DNA; DNA Repair; Paramecium; Radiation Effects; Thy | 1974 |
[When may aged persons drink coffee?].
Topics: Adrenal Glands; Aged; Aging; Caffeine; Cardiovascular System; Central Nervous System; Coffee; Corona | 1972 |
The effect of ageing, caffeine-treatment, and ionizing-radiation on nucleic acid synthesis in the mouse liver.
Topics: Aging; Animals; Caffeine; Carbon Isotopes; DNA; Hepatectomy; Liver; Liver Regeneration; Male; Mice; | 1971 |
[Effect of age on the effects of caffeine on the function and metabolism of the heart].
Topics: Adenosine Triphosphate; Aging; Animals; Blood Pressure; Caffeine; Cardiac Output; Carotid Arteries; | 1970 |
[New paths in geriatric therapy].
Topics: Adult; Aged; Aging; Caffeine; Capillary Permeability; Cardiovascular System; Epinephrine; Humans; Hy | 1965 |