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caffeine and Adenocarcinoma

caffeine has been researched along with Adenocarcinoma in 30 studies

Adenocarcinoma: A malignant epithelial tumor with a glandular organization.

Research Excerpts

ExcerptRelevanceReference
"We investigated p53-dependent and -independent molecular events associated with cell cycle alteration and cell death in human lung adenocarcinoma A549 cells using cryptolepine, a DNA-damaging agent."7.73Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells. ( Gooderham, NJ; Zhu, H, 2006)
"The present study investigated the inhibitory effects of Polyphenon E [a standardized green tea polyphenol preparation containing 65% (-)-epigallocatechin-3-gallate] and caffeine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumor progression from adenoma to adenocarcinoma."7.73Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. ( Hao, X; Liao, J; Lu, G; Reuhl, KR; Yang, CS; Yang, G, 2006)
"Caffeine could enhance the effectiveness of an existing drug for CRC treatment despite having little impact on the cell survival rate of CRC cells."5.91Caffeine enhances chemosensitivity to irinotecan in the treatment of colorectal cancer. ( Kim, KP; Lee, BK; Yoon, S, 2023)
" For combined treatment with caffeine and paclitaxel, added caffeine reduced the cytotoxic effect of paclitaxel not only in dose-response but also in time-response curves."5.32Caffeine diminishes cytotoxic effects of paclitaxel on a human lung adenocarcinoma cell line. ( Akimoto, T; Kitamoto, Y; Mitsuhashi, N; Nakano, T; Sakurai, H, 2003)
"In a phase I-II study, 28 patients with advanced pancreatic adenocarcinoma were treated with cisplatin, high-dose cytarabine (ARA-C), and caffeine."5.06Advanced pancreatic cancer: a phase I-II trial of cisplatin, high-dose cytarabine, and caffeine. ( Botet, J; Dougherty, JB; Kelsen, D; Kemeny, N; Magill, G; Niedzwiecki, D, 1989)
"We investigated p53-dependent and -independent molecular events associated with cell cycle alteration and cell death in human lung adenocarcinoma A549 cells using cryptolepine, a DNA-damaging agent."3.73Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells. ( Gooderham, NJ; Zhu, H, 2006)
"The present study investigated the inhibitory effects of Polyphenon E [a standardized green tea polyphenol preparation containing 65% (-)-epigallocatechin-3-gallate] and caffeine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumor progression from adenoma to adenocarcinoma."3.73Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. ( Hao, X; Liao, J; Lu, G; Reuhl, KR; Yang, CS; Yang, G, 2006)
" In this study, we examined the effect of CYP1A2 activity using a urinary caffeine metabolic ratio assay for 54 Chinese women with newly diagnosed lung cancer (including 28 adenocarcinomas) and 174 hospital controls."3.71Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in Singapore. ( Eng, P; Lee, EJ; Lee, HP; Poh, WT; Seow, A; Tan, WC; Teh, M; Wang, YT; Zhao, B, 2001)
"We have examined the modulation of radiosensitivity by using caffeine in two human sarcoma cell lines both with a p53 mutation (US8-93 and LMS6-93)."3.71Loss of G2/M arrest correlates with radiosensitization in two human sarcoma cell lines with mutant p53. ( Bache, M; Bartel, F; Dunst, J; Meye, A; Pigorsch, S; Rath, FW; Schmidt, H; Taubert, H; Würl, P, 2001)
"A study of MCF-7 human breast cancer cells was undertaken to ascertain the degree of apoptosis induction by paclitaxel and if the induction of apoptosis could be enhanced by caffeine."3.69Paclitaxel-induced apoptosis in MCF-7 breast-cancer cells. ( Christensen, C; Deppe, G; Lawrence, WD; Ruan, H; Saunders, DE; Wappler, NL, 1997)
"In locally advanced pancreatic cancer, the utilization of chemotherapy and radiotherapy is increasing, although in view of the reported long-term results of several contemporary trials, further improvements are certainly needed."2.71Chemoradiotherapy in the treatment of regional pancreatic carcinoma: a phase II study. ( Adsay, V; Al-Sukhun, S; Ben-Josef, E; Forman, JD; Heilbrun, LK; Levin, K; Philip, PA; Shields, AF; Soulen, R; Vaitkevicius, VK; Weaver, D; Zalupski, MM, 2003)
"Caffeine could enhance the effectiveness of an existing drug for CRC treatment despite having little impact on the cell survival rate of CRC cells."1.91Caffeine enhances chemosensitivity to irinotecan in the treatment of colorectal cancer. ( Kim, KP; Lee, BK; Yoon, S, 2023)
"We therefore used LNCaP human prostate cancer cells as a model to identify stimuli that lead to AIbZIP activation and define the transcriptional targets of AIbZIP."1.34Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells. ( Ben Aicha, S; Calvo, E; Fournier, A; Labrie, C; Lessard, J; Pelletier, M, 2007)
" For combined treatment with caffeine and paclitaxel, added caffeine reduced the cytotoxic effect of paclitaxel not only in dose-response but also in time-response curves."1.32Caffeine diminishes cytotoxic effects of paclitaxel on a human lung adenocarcinoma cell line. ( Akimoto, T; Kitamoto, Y; Mitsuhashi, N; Nakano, T; Sakurai, H, 2003)
"Hyperoxia has been shown to cause DNA damage resulting in growth arrest of cells in p53-dependent, as well as p53-independent, pathways."1.32Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites. ( Das, KC; Dashnamoorthy, R, 2004)
"Caffeine is a model radiosensitizing agent that is thought to work by abrogating the radiation-induced G(2)-phase checkpoint."1.31Caffeine induces TP53-independent G(1)-phase arrest and apoptosis in human lung tumor cells in a dose-dependent manner. ( Martinez, JD; Qi, W; Qiao, D, 2002)
"Pancreatic cancer is the fifth leading cause of cancer related deaths in the United States."1.30Molecular effects of taxol and caffeine on pancreatic cancer cells. ( Al-Katib, AA; Aranha, O; Gururajanna, B; Li, YW; Sarkar, FH; Vaitkevicius, VK, 1999)
"Both caffeine and NaCl treatments exerted growth retardation effects, the suppression being stronger with caffeine than NaCl, and animals in group 1 (NaCl plus caffeine) showing the lowest body weight."1.29Effects of caffeine on glandular stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride. ( Furukawa, F; Hasegawa, T; Ikezaki, S; Imazawa, T; Nishikawa, A; Takahashi, M, 1995)
"The tumor lines were hepatocellular carcinoma and colon adenocarcinoma."1.29Differential radiosensitization of radioresistant human cancer cells by caffeine. ( Boonkitticharoen, V; Laohathai, K; Puribhat, S, 1993)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19906 (20.00)18.7374
1990's9 (30.00)18.2507
2000's12 (40.00)29.6817
2010's1 (3.33)24.3611
2020's2 (6.67)2.80

Authors

AuthorsStudies
Cheng, S1
Li, Z1
Bai, X1
Feng, J1
Su, R1
Song, L1
Yang, H1
Zhan, X1
Xia, X1
Lü, X1
Shi, C1
Yoon, S1
Lee, BK1
Kim, KP1
Arab, L1
Su, LJ1
Steck, SE1
Ang, A1
Fontham, ET1
Bensen, JT1
Mohler, JL1
Kitamoto, Y1
Sakurai, H1
Mitsuhashi, N1
Akimoto, T1
Nakano, T1
Das, KC1
Dashnamoorthy, R1
Al-Sukhun, S1
Zalupski, MM2
Ben-Josef, E1
Vaitkevicius, VK3
Philip, PA1
Soulen, R1
Weaver, D1
Adsay, V1
Heilbrun, LK1
Levin, K1
Forman, JD1
Shields, AF2
Al-Wadei, HA1
Takahashi, T1
Schuller, HM1
Zhu, H1
Gooderham, NJ1
Lu, G1
Liao, J1
Yang, G1
Reuhl, KR1
Hao, X1
Yang, CS1
Ben Aicha, S1
Lessard, J1
Pelletier, M1
Fournier, A1
Calvo, E1
Labrie, C1
Murnane, JP1
Byfield, JE1
Chen, CT1
Wang, CH1
Johansson, SL1
Russell, KJ1
Wiens, LW1
Demers, GW1
Galloway, DA1
Plon, SE1
Groudine, M1
Nishikawa, A1
Furukawa, F1
Imazawa, T1
Ikezaki, S1
Hasegawa, T1
Takahashi, M1
Boonkitticharoen, V1
Laohathai, K1
Puribhat, S1
Clunes, MT1
Kemp, PJ1
Saunders, DE1
Lawrence, WD1
Christensen, C1
Wappler, NL1
Ruan, H1
Deppe, G1
Hagiwara, A1
Boonyaphiphat, P1
Tanaka, H1
Kawabe, M1
Tamano, S1
Kaneko, H1
Matsui, M1
Hirose, M1
Ito, N1
Shirai, T1
Gururajanna, B1
Al-Katib, AA1
Li, YW1
Aranha, O1
Sarkar, FH1
Tunca, B1
Egeli, U1
Zorluoglu, A1
Yilmazlar, T1
Yerci, O1
Kizil, A1
Ahmed, S1
Du, W1
Arlauskas, P1
Gordon, C1
Kellogg, C1
Seow, A1
Zhao, B1
Lee, EJ1
Poh, WT1
Teh, M1
Eng, P1
Wang, YT1
Tan, WC1
Lee, HP1
Bache, M1
Pigorsch, S1
Dunst, J1
Würl, P1
Meye, A1
Bartel, F1
Schmidt, H1
Rath, FW1
Taubert, H1
Qi, W1
Qiao, D1
Martinez, JD1
Kelsen, D2
Hudis, C1
Niedzwiecki, D2
Dougherty, J1
Casper, E1
Botet, J2
Vinciguerra, V1
Rosenbluth, R1
Ohsaki, Y1
Ishida, S1
Fujikane, T1
Akiba, Y1
Osanai, S1
Onodera, S1
Dougherty, JB1
Kemeny, N1
Magill, G1
Coffey, RJ1
Go, VL1
Zinsmeister, AR1
DiMagno, EP1
Kyriazis, AP1
Kyriazis, AA1
Yagoda, A1
Liu, T1
Smith, GW1
Rankin, JT1

Trials

4 trials available for caffeine and Adenocarcinoma

ArticleYear
Chemoradiotherapy in the treatment of regional pancreatic carcinoma: a phase II study.
    American journal of clinical oncology, 2003, Volume: 26, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Caff

2003
Cisplatin, cytarabine, caffeine, and continuously infused 5-fluorouracil (PACE) in the treatment of advanced pancreatic carcinoma: a phase II study.
    American journal of clinical oncology, 2000, Volume: 23, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic

2000
A phase III comparison trial of streptozotocin, mitomycin, and 5-fluorouracil with cisplatin, cytosine arabinoside, and caffeine in patients with advanced pancreatic carcinoma.
    Cancer, 1991, Sep-01, Volume: 68, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Caffeine; Carboplatin;

1991
Advanced pancreatic cancer: a phase I-II trial of cisplatin, high-dose cytarabine, and caffeine.
    Journal of the National Cancer Institute, 1989, Nov-15, Volume: 81, Issue:22

    Topics: Acute Disease; Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Caffeine; Cisplatin;

1989

Other Studies

26 other studies available for caffeine and Adenocarcinoma

ArticleYear
The biochemical characteristics of viable but nonculturable state Yersinia enterocolitica induced by lactic acid stress and its presence in food systems.
    Food research international (Ottawa, Ont.), 2023, Volume: 170

    Topics: Adenocarcinoma; Caco-2 Cells; Caffeine; Humans; Lactic Acid; Yersinia enterocolitica

2023
Caffeine enhances chemosensitivity to irinotecan in the treatment of colorectal cancer.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 121

    Topics: Adenocarcinoma; Caffeine; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; D

2023
Coffee consumption and prostate cancer aggressiveness among African and Caucasian Americans in a population-based study.
    Nutrition and cancer, 2012, Volume: 64, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Black or African American; Caffeine; Coffee; Diet; Humans; Louisiana; M

2012
Caffeine diminishes cytotoxic effects of paclitaxel on a human lung adenocarcinoma cell line.
    Cancer letters, 2003, Feb-28, Volume: 191, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Caffeine; Depression, Chemical; Dose-Response Rel

2003
Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.
    American journal of physiology. Lung cellular and molecular physiology, 2004, Volume: 286, Issue:1

    Topics: Adenocarcinoma; Androstadienes; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Protein

2004
Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB and ERK1/2.
    Oncology reports, 2006, Volume: 15, Issue:2

    Topics: Adenocarcinoma; Blotting, Western; Caffeine; Cell Line, Tumor; Central Nervous System Stimulants; CR

2006
Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 91, Issue:1

    Topics: Adenocarcinoma; Alkaloids; Androstadienes; Apoptosis; Caffeine; Cell Cycle; Cell Line, Tumor; Chromo

2006
Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine.
    Cancer research, 2006, Dec-01, Volume: 66, Issue:23

    Topics: Adenocarcinoma; Adenoma; Analysis of Variance; Animals; Caffeine; Catechin; Cell Proliferation; Dise

2006
Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells.
    Physiological genomics, 2007, Oct-22, Volume: 31, Issue:2

    Topics: Adenocarcinoma; Amino Acid Sequence; Basic-Leucine Zipper Transcription Factors; Brefeldin A; Caffei

2007
The structure of methylated xanthines in relation to their effects on DNA synthesis and cell lethality in nitrogen mustard-treated cells.
    Biophysical journal, 1981, Volume: 35, Issue:3

    Topics: Adenocarcinoma; Caffeine; Cell Line; Cell Survival; DNA Replication; Humans; Mechlorethamine; Struct

1981
Carcinogenicity of analgesics: long-term treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen).
    International journal of cancer, 1981, Volume: 27, Issue:4

    Topics: Acetaminophen; Adenocarcinoma; Analgesics; Animals; Antipyrine; Caffeine; Carcinogens; Carcinoma, Sq

1981
Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells.
    Cancer research, 1995, Apr-15, Volume: 55, Issue:8

    Topics: Adenocarcinoma; Caffeine; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Radia

1995
Effects of caffeine on glandular stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:1

    Topics: Adenocarcinoma; Animals; Biological Assay; Body Weight; Caffeine; Cell Division; Drug Interactions;

1995
Differential radiosensitization of radioresistant human cancer cells by caffeine.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1993, Volume: 76, Issue:5

    Topics: Adenocarcinoma; Caffeine; Carcinoma, Hepatocellular; Colonic Neoplasms; Gamma Rays; Humans; Radiatio

1993
P2u purinoceptor modulation of intracellular Ca2+ in a human lung adenocarcinoma cell line: down-regulation of Ca2+ influx by protein kinase C.
    Cell calcium, 1996, Volume: 20, Issue:4

    Topics: Adenocarcinoma; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Benzoquinone

1996
Paclitaxel-induced apoptosis in MCF-7 breast-cancer cells.
    International journal of cancer, 1997, Jan-17, Volume: 70, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasm

1997
Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants alpha-tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary and colonic carcinogenesis in female F344
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:4

    Topics: Adenocarcinoma; Adenoma; Animals; Antioxidants; Caffeine; Carcinogens; Chemoprevention; Colonic Neop

1999
Molecular effects of taxol and caffeine on pancreatic cancer cells.
    International journal of molecular medicine, 1999, Volume: 4, Issue:5

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Caffei

1999
The expression frequency of common fragile sites and genetic predisposition to colon cancer.
    Cancer genetics and cytogenetics, 2000, Volume: 119, Issue:2

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Alu Elements; Aphidicolin; Bromodeoxyuridine; Caffeine; Chi

2000
Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in Singapore.
    Carcinogenesis, 2001, Volume: 22, Issue:4

    Topics: Adenocarcinoma; Age Factors; Aged; Arylamine N-Acetyltransferase; Caffeine; Case-Control Studies; Ch

2001
Loss of G2/M arrest correlates with radiosensitization in two human sarcoma cell lines with mutant p53.
    International journal of cancer, 2001, Apr-20, Volume: 96, Issue:2

    Topics: Adenocarcinoma; Alleles; Apoptosis; Blotting, Western; Caffeine; Cell Survival; Combined Modality Th

2001
Caffeine induces TP53-independent G(1)-phase arrest and apoptosis in human lung tumor cells in a dose-dependent manner.
    Radiation research, 2002, Volume: 157, Issue:2

    Topics: Adenocarcinoma; Apoptosis; Caffeine; CDC2 Protein Kinase; CDC2-CDC28 Kinases; cdc25 Phosphatases; Ce

2002
[Combination effect of caffeine and cisplatin on a cisplatin resistant human lung cancer cell line].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:7

    Topics: Adenocarcinoma; Caffeine; Cell Cycle; Cisplatin; Drug Resistance; Drug Synergism; Humans; Lung Neopl

1990
The acute effects of coffee and caffeine on human interdigestive exocrine pancreatic secretion.
    Pancreas, 1986, Volume: 1, Issue:1

    Topics: Adenocarcinoma; Adult; Caffeine; Coffee; Fasting; Female; Gastric Acid; Gastrins; Humans; Male; Midd

1986
Enhanced therapeutic effect of cis-diamminedichloroplatinum(II) against nude mouse grown human pancreatic adenocarcinoma when combined with 1-beta-D-arabinofuranosylcytosine and caffeine.
    Cancer research, 1985, Volume: 45, Issue:12 Pt 1

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Caffeine; Cisplatin; Cytara

1985
Renal pelvic tumour associated with analgesic abuse.
    Canadian Medical Association journal, 1972, Oct-21, Volume: 107, Issue:8

    Topics: Adenocarcinoma; Aged; Alcoholism; Analgesics; Aspirin; Caffeine; Codeine; Drug Synergism; Female; Hu

1972