caffeine has been researched along with Acute Pain in 6 studies
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243." | 8.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| " Most studies used paracetamol or ibuprofen, with 100 mg to 130 mg caffeine, and the most common pain conditions studied were postoperative dental pain, postpartum pain, and headache." | 8.88 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2012) |
| "This appears to be broadly true in postoperative pain and migraine headache across a range of different drug combinations, and when tested in the same and different trials." | 6.52 | Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults. ( Derry, S; Moore, RA; Wiffen, PJ, 2015) |
| " The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243." | 4.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| " Most studies used paracetamol or ibuprofen, with 100 mg to 130 mg caffeine, and the most common pain conditions studied were postoperative dental pain, postpartum pain, and headache." | 4.88 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2012) |
| "This appears to be broadly true in postoperative pain and migraine headache across a range of different drug combinations, and when tested in the same and different trials." | 2.52 | Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults. ( Derry, S; Moore, RA; Wiffen, PJ, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Förderreuther, S | 1 |
| Lampert, A | 1 |
| Hitier, S | 1 |
| Lange, R | 1 |
| Weiser, T | 1 |
| Nikolajsen, L | 1 |
| Haroutiunian, S | 1 |
| Derry, CJ | 2 |
| Derry, S | 3 |
| Moore, RA | 3 |
| Wiffen, PJ | 1 |
| Bergese, S | 1 |
| Castellon-Larios, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single-centre, Double-blind, Randomised, Two-stage, Parallel-group Study to Assess the Efficacy and Safety of the Fixed Dose Combination of Ibuprofen 400 mg and Caffeine 100 mg Versus Ibuprofen 400 mg, Caffeine 100 mg and Placebo in Patients With Postop[NCT01929031] | Phase 3 | 562 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Duration of pain relief was defined as the time between the administration of first dose of trial medication and first dose of rescue medication or second dose of trial medication, whichever was first. Duration of pain relief was censored at 8 hours. (NCT01929031)
Timeframe: 8 hours
| Intervention | hours (Median) |
|---|---|
| Placebo | 1.63 |
| Caffeine | 2.08 |
| Ibuprofen | 7.11 |
| Ibuprofen/Caffeine | 7.33 |
Time to meaningful pain relief was captured by a stopwatch, which was started by the study staff immediately after the administration of the first dose of trial medication and which was to be stopped by the patient as soon as he/she felt meaningful pain relief. Time to meaningful pain relief was censored at 8 hours. (NCT01929031)
Timeframe: 8 hours
| Intervention | hours (Median) |
|---|---|
| Placebo | NA |
| Caffeine | NA |
| Ibuprofen | 1.78 |
| Ibuprofen/Caffeine | 1.13 |
SPRID0-2h: Time-weighted sum of PAR and PID from 0 to 2 hours, score range: -10 (worst) to 28 (best). PI was assessed on a 0-10 numerical pain rating scale (NPRS), where 0=no pain and 10=worst possible pain, pre-dose and at 0.25,0.5,0.75,1,1.5 and 2 hours; PAR was assessed on a 5-point verbal rating scale (VRS) (0=none to 4=complete) at the same post-dose time points. Time-weights were equal to the elapsed time (hour) between the time point of interest and the preceding time point. All PAR and pain intensity (PI) assessments completed after the patient had taken rescue medication or the second dose of study medication, whichever was first, until hour 2 was considered missing. Last observation carried forward (LOCF) was used with the last completed PI/PAR assessments prior to first rescue/second study medication, whichever was first, to impute missing values up to 2 hours. (NCT01929031)
Timeframe: 0 to 2 hours
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | 2.059 |
| Caffeine | 2.612 |
| Ibuprofen | 6.990 |
| Ibuprofen/Caffeine | 10.584 |
SPRID0-8h: Time-weighted sum of PAR and PID from 0 to 8 hours, score range: -40 (worst) to 112 (best). PI was assessed on a 0-10 numerical pain rating scale (NPRS), where 0=no pain and 10=worst possible pain, pre-dose and at 0.25,0.5,0.75,1,1.5,2,3,4,5, 6,7 and 8 hours; PAR was assessed on a 5-point verbal rating scale (VRS) (0=none to 4=complete) at the same post-dose time points. Time-weights were equal to the elapsed time (hour) between the time point of interest and the preceding time point. All PAR and pain intensity (PI) assessments completed after the patient had taken rescue medication or the second dose of study medication, whichever was first, until hour 8 were considered missing. Last observation carried forward (LOCF) was used with the last completed PI/PAR assessments prior to first rescue/second study medication, whichever was first, to impute missing values up to 8 hours. (NCT01929031)
Timeframe: 0 to 8 hours
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Placebo | 10.554 |
| Caffeine | 15.824 |
| Ibuprofen | 40.165 |
| Ibuprofen/Caffeine | 52.291 |
3 reviews available for caffeine and Acute Pain
| Article | Year |
|---|---|
Caffeine as an analgesic adjuvant for acute pain in adults.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics; Caffeine; Chemotherapy, Adjuvant; Di | 2014 |
Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults.
Topics: Acute Pain; Adult; Analgesics, Non-Narcotic; Caffeine; Drug Combinations; Humans; Ibuprofen; Numbers | 2015 |
Caffeine as an analgesic adjuvant for acute pain in adults.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Caffeine; Chemotherapy, Adjuvant; Female; Headache; Hu | 2012 |
1 trial available for caffeine and Acute Pain
| Article | Year |
|---|---|
The Impact of Baseline Pain Intensity on the Analgesic Efficacy of Ibuprofen/Caffeine in Patients with Acute Postoperative Dental Pain: Post Hoc Subgroup Analysis of a Randomised Controlled Trial.
Topics: Acute Pain; Adolescent; Adult; Analgesics; Caffeine; Dose-Response Relationship, Drug; Double-Blind | 2020 |
2 other studies available for caffeine and Acute Pain
| Article | Year |
|---|---|
[Caffeine as adjuvant analgeticum for treating acute pain].
Topics: Acute Pain; Adult; Analgesics; Caffeine; Chemotherapy, Adjuvant; Humans; Review Literature as Topic | 2013 |
The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults.
Topics: Acute Pain; Analgesics, Non-Narcotic; Caffeine; Humans; Ibuprofen; Pain, Postoperative | 2016 |