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caffeine and Acute Liver Injury, Drug-Induced

caffeine has been researched along with Acute Liver Injury, Drug-Induced in 47 studies

Research Excerpts

ExcerptRelevanceReference
"Acetaminophen (APAP) is a widely used analgesic drug that is frequently co-administered with caffeine (CAF) in the treatment of pain."3.85Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans. ( Baier, V; Blank, LM; Cordes, H; Kuepfer, L; Thiel, C, 2017)
"Caffeine was pre-treated in L02 cells or mice."1.72Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination. ( Cao, LP; Fu, YM; Hu, XW; Li, J; Li, XM; Long, H; Wang, AM; Xiong, YH; Xu, J; Zeng, F; Zhang, FJ, 2022)
"Hemorrhage was present in the kidneys of all groups."1.48Energy drink and alcohol combination leads to kidney and liver alterations in rats. ( Altknecht, L; Arbo, MD; Cestonaro, LV; Costa-Valle, MT; Cunha, CD; Dallegrave, E; Fão, N; Garcia, SC; Göethel, G; Leal, MB; Tonieto, BD, 2018)
"Amiodarone was then tested and simulations were performed under repeated exposure conditions in HepaRG."1.46Practical use of the Virtual Cell Based Assay: Simulation of repeated exposure experiments in liver cell lines. ( Gerloff, K; Horvat, T; Mennecozzi, M; Paini, A; Palosaari, T; Sala Benito, JV; Worth, A, 2017)
"Co-treatment with caffeine and TAA restored normal liver structure and function."1.46Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: Biochemical and histological study. ( Amer, MG; Mazen, NF; Mohamed, AM, 2017)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)
"Pretreatment with caffeine, nicotinic acid or non-substituted pyrazinoic acid activated the LPS/D-GalN induced elevation of plasma IL-10 levels at 1 and 2 h, although there were no statistically significant differences in IL-10 levels between control and nicotinic acid or non-substituted pyrazinoic acid treated rats."1.35Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats. ( Akashi, I; Hirano, T; Kagami, K; Oka, K, 2009)
"Caffeine was a competitive inhibitor of APAP bioactivation in microsomes from beta NF- and acetone-treated mice."1.29Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents. ( Jaw, S; Jeffery, EH, 1993)
"With aminopyrine the decrease was abrupt but with caffeine biphasic, consistent with preferential isozyme depletion."1.28A model of cytochrome P-450-centered hepatic dysfunction in drug metabolism induced by cobalt-protoporphyrin administration. ( Halter, S; Hanew, T; Muhoberac, BB; Schenker, S, 1989)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199010 (21.28)18.7374
1990's4 (8.51)18.2507
2000's14 (29.79)29.6817
2010's17 (36.17)24.3611
2020's2 (4.26)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Morgan, RE2
Trauner, M1
van Staden, CJ2
Lee, PH1
Ramachandran, B1
Eschenberg, M1
Afshari, CA2
Qualls, CW1
Lightfoot-Dunn, R1
Hamadeh, HK2
Ekins, S1
Williams, AJ1
Xu, JJ1
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W2
Sakatis, MZ1
Reese, MJ1
Harrell, AW1
Taylor, MA1
Baines, IA1
Chen, L1
Bloomer, JC1
Yang, EY1
Ellens, HM1
Ambroso, JL1
Lovatt, CA1
Ayrton, AD1
Clarke, SE1
Warner, DJ1
Chen, H1
Cantin, LD1
Kenna, JG1
Stahl, S1
Walker, CL1
Noeske, T1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Chen, M1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Hu, XW1
Li, XM1
Wang, AM1
Fu, YM1
Zhang, FJ1
Zeng, F1
Cao, LP1
Long, H1
Xiong, YH1
Xu, J1
Li, J2
Watkins, PB1
Church, RJ1
Knappertz, V1
Gonçalves, DF1
de Carvalho, NR1
Leite, MB1
Courtes, AA1
Hartmann, DD1
Stefanello, ST1
da Silva, IK1
Franco, JL1
Soares, FAA1
Dalla Corte, CL1
Costa-Valle, MT1
Tonieto, BD1
Altknecht, L1
Cunha, CD1
Fão, N1
Cestonaro, LV1
Göethel, G1
Garcia, SC1
Leal, MB1
Dallegrave, E1
Arbo, MD1
Raza, A1
Vierling, J1
Hussain, KB1
Paini, A1
Mennecozzi, M1
Horvat, T1
Gerloff, K1
Palosaari, T1
Sala Benito, JV1
Worth, A1
Thiel, C1
Cordes, H1
Baier, V1
Blank, LM1
Kuepfer, L1
Amer, MG1
Mazen, NF1
Mohamed, AM1
Akashi, I1
Kagami, K1
Hirano, T1
Oka, K1
de Andrade Belo, MA1
Soares, VE1
de Souza, LM1
da Rosa Sobreira, MF1
Cassol, DM1
Toma, SB1
Furtado, KS1
Prado, MG1
Aguiar E Silva, MA1
Dias, MC1
Rivelli, DP1
Rodrigues, MA1
Barbisan, LF1
Ozono, S1
Yamaguchi, A1
Mochizuki, H1
Kawakami, T1
Fujimoto, K1
Otani, T1
Yoshida, K1
Ichinei, M1
Yamashita, T1
Hirao, Y1
Abe, M1
Kumagi, T1
Nakanishi, S1
Yamagami, T1
Michitaka, K1
Abe, K1
Okura, I1
Yamashita, H1
Horiike, N1
Onji, M1
Estes, JD1
Stolpman, D1
Olyaei, A1
Corless, CL1
Ham, JM1
Schwartz, JM1
Orloff, SL1
FISCHER, A1
TAKACS, L1
VARGA, I1
Yokogawa, K1
Watanabe, M1
Takeshita, H1
Nomura, M1
Mano, Y1
Miyamoto, K1
Ohta, A1
Lukashev, D1
Jackson, EK1
Fredholm, BB1
Sitkovsky, M1
Tang, H1
Min, G1
Ge, B1
Li, Y1
Liu, X1
Jiang, S1
Baker, AL1
Kotake, AN1
Schoeller, DA1
Boothe, DM1
Cullen, JM1
Calvin, JA1
Jenkins, WL1
Brown, SA1
Green, RA1
Corrier, DE1
Jaw, S1
Jeffery, EH1
Sugiyama, K3
He, P3
Wada, S1
Saeki, S1
Noda, Y2
Karas, M1
Chakrabarti, SK1
Burdan, F1
Siezieniewska, Z1
Urbanowicz, Z1
Favreau, JT1
Ryu, ML1
Braunstein, G1
Orshansky, G1
Park, SS1
Coody, GL1
Love, LA1
Fong, TL1
Lewis, JD1
Strom, BL1
Zetterman, RK1
Leevy, CM1
Tanaka, E1
Ishikawa, A1
Yamamoto, Y1
Uchida, E1
Kobayashi, S1
Yasuhara, H1
Misawa, S1
Muhoberac, BB1
Hanew, T1
Halter, S1
Schenker, S1
Hoffmann, A1
Reinhardt, M1
Rechenbach, C1
Henschel, L1
Jorke, D1
Gale, GR1
Atkins, LM1
Smith, AB1
Lamar, C1
Walker, EM1
Sato, C1
Izumi, N1
Nouchi, T1
Hasumura, Y1
Takeuchi, J1
Potter, WZ1
Davis, DC1
Mitchell, JR1
Jollow, DJ1
Gillette, JR1
Brodie, BB1
Murray, RM1
Boyd, EM1
Hottenroth, SM1

Reviews

3 reviews available for caffeine and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
Clinical utility of breath tests for the assessment of hepatic function.
    Seminars in liver disease, 1983, Volume: 3, Issue:4

    Topics: Aminopyrine; Breath Tests; Caffeine; Chemical and Drug Induced Liver Injury; Chronic Disease; Cytoch

1983
Immunologic reactivity and alcoholic liver disease.
    Bulletin of the New York Academy of Medicine, 1975, Volume: 51, Issue:4

    Topics: Acetaldehyde; Alcoholism; Antigen-Antibody Reactions; B-Lymphocytes; Caffeine; Chemical and Drug Ind

1975

Trials

2 trials available for caffeine and Acute Liver Injury, Drug-Induced

ArticleYear
Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial.
    Clinical pharmacology and therapeutics, 2021, Volume: 109, Issue:5

    Topics: Adult; Alanine Transaminase; Caffeine; Cannabidiol; Chemical and Drug Induced Liver Injury; Cytochro

2021
Caffeine test in predicting flutamide-induced hepatic injury in patients with prostate cancer.
    Prostate cancer and prostatic diseases, 2002, Volume: 5, Issue:2

    Topics: Aged; Androgen Antagonists; Caffeine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A

2002

Other Studies

42 other studies available for caffeine and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2022, Volume: 71, Issue:10-11

    Topics: Animals; Apoptosis; Caffeine; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Chaperon

2022
Caffeine and acetaminophen association: Effects on mitochondrial bioenergetics.
    Life sciences, 2018, Jan-15, Volume: 193

    Topics: Acetaminophen; Animals; Antioxidants; Caffeine; Chemical and Drug Induced Liver Injury; Energy Metab

2018
Energy drink and alcohol combination leads to kidney and liver alterations in rats.
    Toxicology and applied pharmacology, 2018, 09-15, Volume: 355

    Topics: Alcoholic Beverages; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Chemica

2018
Genetics of drug-induced hepatotoxicity toxicity in Gilbert's syndrome.
    The American journal of gastroenterology, 2013, Volume: 108, Issue:12

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Chemical and Drug Induced

2013
Practical use of the Virtual Cell Based Assay: Simulation of repeated exposure experiments in liver cell lines.
    Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 45, Issue:Pt 2

    Topics: Amiodarone; Animal Testing Alternatives; Caffeine; Cell Line; Cell Survival; Chemical and Drug Induc

2017
Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.
    CPT: pharmacometrics & systems pharmacology, 2017, Volume: 6, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Chemical and Drug Induced Liver In

2017
Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: Biochemical and histological study.
    International journal of immunopathology and pharmacology, 2017, Volume: 30, Issue:1

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antioxidants; Asparta

2017
Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:4

    Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Drug I

2009
Hepatoprotective treatment attenuates oxidative damages induced by carbon tetrachloride in rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2012, Volume: 64, Issue:3

    Topics: Animals; Antioxidants; Caffeine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Femal

2012
Coffee and caffeine protect against liver injury induced by thioacetamide in male Wistar rats.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:5

    Topics: Animals; Caffeine; Caspase 3; Chemical and Drug Induced Liver Injury; Coffee; Collagen; Food Handlin

2012
Drug-induced hepatitis with hepatic granuloma due to saridon.
    Journal of gastroenterology, 2002, Volume: 37, Issue:12

    Topics: Adult; Antipyrine; Biopsy, Needle; Caffeine; Chemical and Drug Induced Liver Injury; Dose-Response R

2002
High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure.
    Archives of surgery (Chicago, Ill. : 1960), 2003, Volume: 138, Issue:8

    Topics: Adult; Benzofurans; Benzopyrans; Caffeine; Chemical and Drug Induced Liver Injury; Dietary Supplemen

2003
[STUDY OF THE INTERMEDIATE METABOLISM OF DRUGS USING PARTIAL HEPATECTOMY].
    Kiserletes orvostudomany, 1963, Volume: 15

    Topics: Barbiturates; Caffeine; Chemical and Drug Induced Liver Injury; Chloralose; Hepatectomy; Hepatitis;

1963
Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride.
    International journal of pharmaceutics, 2004, Jan-28, Volume: 269, Issue:2

    Topics: Animals; Area Under Curve; Caffeine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver

2004
1,3,7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Dec-01, Volume: 179, Issue:11

    Topics: Acute Disease; Adenosine A2 Receptor Antagonists; ADP Ribose Transferases; Animals; Bacterial Toxins

2007
Evaluation of protective effects of Chi-Zhi-Huang decoction on Phase I drug metabolism of liver injured rats by cocktail probe drugs.
    Journal of ethnopharmacology, 2008, May-22, Volume: 117, Issue:3

    Topics: Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotransferases; Bilirubin; Caffeine; C

2008
Antipyrine and caffeine dispositions in clinically normal dogs and dogs with progressive liver disease.
    American journal of veterinary research, 1994, Volume: 55, Issue:2

    Topics: Analysis of Variance; Animals; Antipyrine; Caffeine; Chemical and Drug Induced Liver Injury; Chromat

1994
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
    Biochemical pharmacology, 1993, Aug-03, Volume: 46, Issue:3

    Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflav

1993
Teas and other beverages suppress D-galactosamine-induced liver injury in rats.
    The Journal of nutrition, 1999, Volume: 129, Issue:7

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Beverages; Blood G

1999
Suppressive effect of caffeine on hepatitis and apoptosis induced by tumor necrosis factor-alpha, but not by the anti-Fas antibody, in mice.
    Bioscience, biotechnology, and biochemistry, 2001, Volume: 65, Issue:3

    Topics: Alanine Transaminase; Animals; Antibodies, Monoclonal; Apoptosis; Aspartate Aminotransferases; Caffe

2001
Influence of caffeine on allyl alcohol-induced hepatotoxicity in rats. I. In vivo study.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2001, Volume: 20, Issue:2

    Topics: Acrolein; Alanine Transaminase; Alcohol Dehydrogenase; Animals; Caffeine; Chemical and Drug Induced

2001
Suppressive effect of coffee on lipopolysaccharide-induced hepatitis in D-galactosamine-sensitized rats.
    Bioscience, biotechnology, and biochemistry, 2001, Volume: 65, Issue:8

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Drug Induced Live

2001
Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver.
    Human & experimental toxicology, 2001, Volume: 20, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrin

2001
Severe hepatotoxicity associated with the dietary supplement LipoKinetix.
    Annals of internal medicine, 2002, Apr-16, Volume: 136, Issue:8

    Topics: Acute Kidney Injury; Adult; Adverse Drug Reaction Reporting Systems; Benzofurans; Benzopyrans; Caffe

2002
Balancing safety of dietary supplements with the free market.
    Annals of internal medicine, 2002, Apr-16, Volume: 136, Issue:8

    Topics: Benzofurans; Benzopyrans; Caffeine; Chemical and Drug Induced Liver Injury; Dietary Supplements; Dii

2002
Summary for patients. Liver failure associated with the dietary supplement LipoKinetix.
    Annals of internal medicine, 2002, Apr-16, Volume: 136, Issue:8

    Topics: Acute Kidney Injury; Adult; Adverse Drug Reaction Reporting Systems; Benzofurans; Benzopyrans; Caffe

2002
Simplified approach for evaluation of hepatic drug-oxidizing capacity with a simultaneous measurement of caffeine and its primary demethylated metabolites in carbon tetrachloride-intoxicated rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:5

    Topics: Administration, Oral; Animals; Caffeine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced L

1992
A model of cytochrome P-450-centered hepatic dysfunction in drug metabolism induced by cobalt-protoporphyrin administration.
    Biochemical pharmacology, 1989, Nov-15, Volume: 38, Issue:22

    Topics: Aminopyrine; Animals; Breath Tests; Caffeine; Carbon Dioxide; Chemical and Drug Induced Liver Injury

1989
[Biotransformation in patients following Depressan-induced hepatitis].
    Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR, 1989, Volume: 49, Issue:1

    Topics: Adult; Aged; Biotransformation; Caffeine; Chemical and Drug Induced Liver Injury; Dihydralazine; Fem

1989
Acetaminophen-induced hepatotoxicity: antagonistic action of caffeine in mice.
    Research communications in chemical pathology and pharmacology, 1987, Volume: 55, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Binding Sites; Cadmium; C

1987
Increased hepatotoxicity of acetaminophen by concomitant administration of caffeine in the rat.
    Toxicology, 1985, Volume: 34, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Dr

1985
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1

    Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced L

1973
Dependance on analgesics in analgesic nephropathy.
    The British journal of addiction to alcohol and other drugs, 1973, Volume: 68, Issue:3

    Topics: Adult; Aged; Analgesics; Aspirin; Caffeine; Chemical and Drug Induced Liver Injury; Codeine; Female;

1973
The toxicity of phenacetin at the range of the oral LD50(100 days) in albino rats.
    Toxicology and applied pharmacology, 1968, Volume: 12, Issue:1

    Topics: Animals; Asthenia; Ataxia; Caffeine; Chemical and Drug Induced Liver Injury; Cyanosis; Dehydration;

1968