caffeine has been researched along with Acute Liver Injury, Drug-Induced in 47 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen (APAP) is a widely used analgesic drug that is frequently co-administered with caffeine (CAF) in the treatment of pain." | 3.85 | Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans. ( Baier, V; Blank, LM; Cordes, H; Kuepfer, L; Thiel, C, 2017) |
| "Caffeine was pre-treated in L02 cells or mice." | 1.72 | Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination. ( Cao, LP; Fu, YM; Hu, XW; Li, J; Li, XM; Long, H; Wang, AM; Xiong, YH; Xu, J; Zeng, F; Zhang, FJ, 2022) |
| "Hemorrhage was present in the kidneys of all groups." | 1.48 | Energy drink and alcohol combination leads to kidney and liver alterations in rats. ( Altknecht, L; Arbo, MD; Cestonaro, LV; Costa-Valle, MT; Cunha, CD; Dallegrave, E; Fão, N; Garcia, SC; Göethel, G; Leal, MB; Tonieto, BD, 2018) |
| "Amiodarone was then tested and simulations were performed under repeated exposure conditions in HepaRG." | 1.46 | Practical use of the Virtual Cell Based Assay: Simulation of repeated exposure experiments in liver cell lines. ( Gerloff, K; Horvat, T; Mennecozzi, M; Paini, A; Palosaari, T; Sala Benito, JV; Worth, A, 2017) |
| "Co-treatment with caffeine and TAA restored normal liver structure and function." | 1.46 | Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: Biochemical and histological study. ( Amer, MG; Mazen, NF; Mohamed, AM, 2017) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Pretreatment with caffeine, nicotinic acid or non-substituted pyrazinoic acid activated the LPS/D-GalN induced elevation of plasma IL-10 levels at 1 and 2 h, although there were no statistically significant differences in IL-10 levels between control and nicotinic acid or non-substituted pyrazinoic acid treated rats." | 1.35 | Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats. ( Akashi, I; Hirano, T; Kagami, K; Oka, K, 2009) |
| "Caffeine was a competitive inhibitor of APAP bioactivation in microsomes from beta NF- and acetone-treated mice." | 1.29 | Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents. ( Jaw, S; Jeffery, EH, 1993) |
| "With aminopyrine the decrease was abrupt but with caffeine biphasic, consistent with preferential isozyme depletion." | 1.28 | A model of cytochrome P-450-centered hepatic dysfunction in drug metabolism induced by cobalt-protoporphyrin administration. ( Halter, S; Hanew, T; Muhoberac, BB; Schenker, S, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (21.28) | 18.7374 |
| 1990's | 4 (8.51) | 18.2507 |
| 2000's | 14 (29.79) | 29.6817 |
| 2010's | 17 (36.17) | 24.3611 |
| 2020's | 2 (4.26) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Hu, XW | 1 |
| Li, XM | 1 |
| Wang, AM | 1 |
| Fu, YM | 1 |
| Zhang, FJ | 1 |
| Zeng, F | 1 |
| Cao, LP | 1 |
| Long, H | 1 |
| Xiong, YH | 1 |
| Xu, J | 1 |
| Li, J | 2 |
| Watkins, PB | 1 |
| Church, RJ | 1 |
| Knappertz, V | 1 |
| Gonçalves, DF | 1 |
| de Carvalho, NR | 1 |
| Leite, MB | 1 |
| Courtes, AA | 1 |
| Hartmann, DD | 1 |
| Stefanello, ST | 1 |
| da Silva, IK | 1 |
| Franco, JL | 1 |
| Soares, FAA | 1 |
| Dalla Corte, CL | 1 |
| Costa-Valle, MT | 1 |
| Tonieto, BD | 1 |
| Altknecht, L | 1 |
| Cunha, CD | 1 |
| Fão, N | 1 |
| Cestonaro, LV | 1 |
| Göethel, G | 1 |
| Garcia, SC | 1 |
| Leal, MB | 1 |
| Dallegrave, E | 1 |
| Arbo, MD | 1 |
| Raza, A | 1 |
| Vierling, J | 1 |
| Hussain, KB | 1 |
| Paini, A | 1 |
| Mennecozzi, M | 1 |
| Horvat, T | 1 |
| Gerloff, K | 1 |
| Palosaari, T | 1 |
| Sala Benito, JV | 1 |
| Worth, A | 1 |
| Thiel, C | 1 |
| Cordes, H | 1 |
| Baier, V | 1 |
| Blank, LM | 1 |
| Kuepfer, L | 1 |
| Amer, MG | 1 |
| Mazen, NF | 1 |
| Mohamed, AM | 1 |
| Akashi, I | 1 |
| Kagami, K | 1 |
| Hirano, T | 1 |
| Oka, K | 1 |
| de Andrade Belo, MA | 1 |
| Soares, VE | 1 |
| de Souza, LM | 1 |
| da Rosa Sobreira, MF | 1 |
| Cassol, DM | 1 |
| Toma, SB | 1 |
| Furtado, KS | 1 |
| Prado, MG | 1 |
| Aguiar E Silva, MA | 1 |
| Dias, MC | 1 |
| Rivelli, DP | 1 |
| Rodrigues, MA | 1 |
| Barbisan, LF | 1 |
| Ozono, S | 1 |
| Yamaguchi, A | 1 |
| Mochizuki, H | 1 |
| Kawakami, T | 1 |
| Fujimoto, K | 1 |
| Otani, T | 1 |
| Yoshida, K | 1 |
| Ichinei, M | 1 |
| Yamashita, T | 1 |
| Hirao, Y | 1 |
| Abe, M | 1 |
| Kumagi, T | 1 |
| Nakanishi, S | 1 |
| Yamagami, T | 1 |
| Michitaka, K | 1 |
| Abe, K | 1 |
| Okura, I | 1 |
| Yamashita, H | 1 |
| Horiike, N | 1 |
| Onji, M | 1 |
| Estes, JD | 1 |
| Stolpman, D | 1 |
| Olyaei, A | 1 |
| Corless, CL | 1 |
| Ham, JM | 1 |
| Schwartz, JM | 1 |
| Orloff, SL | 1 |
| FISCHER, A | 1 |
| TAKACS, L | 1 |
| VARGA, I | 1 |
| Yokogawa, K | 1 |
| Watanabe, M | 1 |
| Takeshita, H | 1 |
| Nomura, M | 1 |
| Mano, Y | 1 |
| Miyamoto, K | 1 |
| Ohta, A | 1 |
| Lukashev, D | 1 |
| Jackson, EK | 1 |
| Fredholm, BB | 1 |
| Sitkovsky, M | 1 |
| Tang, H | 1 |
| Min, G | 1 |
| Ge, B | 1 |
| Li, Y | 1 |
| Liu, X | 1 |
| Jiang, S | 1 |
| Baker, AL | 1 |
| Kotake, AN | 1 |
| Schoeller, DA | 1 |
| Boothe, DM | 1 |
| Cullen, JM | 1 |
| Calvin, JA | 1 |
| Jenkins, WL | 1 |
| Brown, SA | 1 |
| Green, RA | 1 |
| Corrier, DE | 1 |
| Jaw, S | 1 |
| Jeffery, EH | 1 |
| Sugiyama, K | 3 |
| He, P | 3 |
| Wada, S | 1 |
| Saeki, S | 1 |
| Noda, Y | 2 |
| Karas, M | 1 |
| Chakrabarti, SK | 1 |
| Burdan, F | 1 |
| Siezieniewska, Z | 1 |
| Urbanowicz, Z | 1 |
| Favreau, JT | 1 |
| Ryu, ML | 1 |
| Braunstein, G | 1 |
| Orshansky, G | 1 |
| Park, SS | 1 |
| Coody, GL | 1 |
| Love, LA | 1 |
| Fong, TL | 1 |
| Lewis, JD | 1 |
| Strom, BL | 1 |
| Zetterman, RK | 1 |
| Leevy, CM | 1 |
| Tanaka, E | 1 |
| Ishikawa, A | 1 |
| Yamamoto, Y | 1 |
| Uchida, E | 1 |
| Kobayashi, S | 1 |
| Yasuhara, H | 1 |
| Misawa, S | 1 |
| Muhoberac, BB | 1 |
| Hanew, T | 1 |
| Halter, S | 1 |
| Schenker, S | 1 |
| Hoffmann, A | 1 |
| Reinhardt, M | 1 |
| Rechenbach, C | 1 |
| Henschel, L | 1 |
| Jorke, D | 1 |
| Gale, GR | 1 |
| Atkins, LM | 1 |
| Smith, AB | 1 |
| Lamar, C | 1 |
| Walker, EM | 1 |
| Sato, C | 1 |
| Izumi, N | 1 |
| Nouchi, T | 1 |
| Hasumura, Y | 1 |
| Takeuchi, J | 1 |
| Potter, WZ | 1 |
| Davis, DC | 1 |
| Mitchell, JR | 1 |
| Jollow, DJ | 1 |
| Gillette, JR | 1 |
| Brodie, BB | 1 |
| Murray, RM | 1 |
| Boyd, EM | 1 |
| Hottenroth, SM | 1 |
3 reviews available for caffeine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Clinical utility of breath tests for the assessment of hepatic function.
Topics: Aminopyrine; Breath Tests; Caffeine; Chemical and Drug Induced Liver Injury; Chronic Disease; Cytoch | 1983 |
Immunologic reactivity and alcoholic liver disease.
Topics: Acetaldehyde; Alcoholism; Antigen-Antibody Reactions; B-Lymphocytes; Caffeine; Chemical and Drug Ind | 1975 |
2 trials available for caffeine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial.
Topics: Adult; Alanine Transaminase; Caffeine; Cannabidiol; Chemical and Drug Induced Liver Injury; Cytochro | 2021 |
Caffeine test in predicting flutamide-induced hepatic injury in patients with prostate cancer.
Topics: Aged; Androgen Antagonists; Caffeine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A | 2002 |
42 other studies available for caffeine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination.
Topics: Animals; Apoptosis; Caffeine; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Chaperon | 2022 |
Caffeine and acetaminophen association: Effects on mitochondrial bioenergetics.
Topics: Acetaminophen; Animals; Antioxidants; Caffeine; Chemical and Drug Induced Liver Injury; Energy Metab | 2018 |
Energy drink and alcohol combination leads to kidney and liver alterations in rats.
Topics: Alcoholic Beverages; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Chemica | 2018 |
Genetics of drug-induced hepatotoxicity toxicity in Gilbert's syndrome.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Chemical and Drug Induced | 2013 |
Practical use of the Virtual Cell Based Assay: Simulation of repeated exposure experiments in liver cell lines.
Topics: Amiodarone; Animal Testing Alternatives; Caffeine; Cell Line; Cell Survival; Chemical and Drug Induc | 2017 |
Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Chemical and Drug Induced Liver In | 2017 |
Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: Biochemical and histological study.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antioxidants; Asparta | 2017 |
Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats.
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Drug I | 2009 |
Hepatoprotective treatment attenuates oxidative damages induced by carbon tetrachloride in rats.
Topics: Animals; Antioxidants; Caffeine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Femal | 2012 |
Coffee and caffeine protect against liver injury induced by thioacetamide in male Wistar rats.
Topics: Animals; Caffeine; Caspase 3; Chemical and Drug Induced Liver Injury; Coffee; Collagen; Food Handlin | 2012 |
Drug-induced hepatitis with hepatic granuloma due to saridon.
Topics: Adult; Antipyrine; Biopsy, Needle; Caffeine; Chemical and Drug Induced Liver Injury; Dose-Response R | 2002 |
High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure.
Topics: Adult; Benzofurans; Benzopyrans; Caffeine; Chemical and Drug Induced Liver Injury; Dietary Supplemen | 2003 |
[STUDY OF THE INTERMEDIATE METABOLISM OF DRUGS USING PARTIAL HEPATECTOMY].
Topics: Barbiturates; Caffeine; Chemical and Drug Induced Liver Injury; Chloralose; Hepatectomy; Hepatitis; | 1963 |
Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride.
Topics: Animals; Area Under Curve; Caffeine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver | 2004 |
1,3,7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism.
Topics: Acute Disease; Adenosine A2 Receptor Antagonists; ADP Ribose Transferases; Animals; Bacterial Toxins | 2007 |
Evaluation of protective effects of Chi-Zhi-Huang decoction on Phase I drug metabolism of liver injured rats by cocktail probe drugs.
Topics: Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotransferases; Bilirubin; Caffeine; C | 2008 |
Antipyrine and caffeine dispositions in clinically normal dogs and dogs with progressive liver disease.
Topics: Analysis of Variance; Animals; Antipyrine; Caffeine; Chemical and Drug Induced Liver Injury; Chromat | 1994 |
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflav | 1993 |
Teas and other beverages suppress D-galactosamine-induced liver injury in rats.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Beverages; Blood G | 1999 |
Suppressive effect of caffeine on hepatitis and apoptosis induced by tumor necrosis factor-alpha, but not by the anti-Fas antibody, in mice.
Topics: Alanine Transaminase; Animals; Antibodies, Monoclonal; Apoptosis; Aspartate Aminotransferases; Caffe | 2001 |
Influence of caffeine on allyl alcohol-induced hepatotoxicity in rats. I. In vivo study.
Topics: Acrolein; Alanine Transaminase; Alcohol Dehydrogenase; Animals; Caffeine; Chemical and Drug Induced | 2001 |
Suppressive effect of coffee on lipopolysaccharide-induced hepatitis in D-galactosamine-sensitized rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Drug Induced Live | 2001 |
Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrin | 2001 |
Severe hepatotoxicity associated with the dietary supplement LipoKinetix.
Topics: Acute Kidney Injury; Adult; Adverse Drug Reaction Reporting Systems; Benzofurans; Benzopyrans; Caffe | 2002 |
Balancing safety of dietary supplements with the free market.
Topics: Benzofurans; Benzopyrans; Caffeine; Chemical and Drug Induced Liver Injury; Dietary Supplements; Dii | 2002 |
Summary for patients. Liver failure associated with the dietary supplement LipoKinetix.
Topics: Acute Kidney Injury; Adult; Adverse Drug Reaction Reporting Systems; Benzofurans; Benzopyrans; Caffe | 2002 |
Simplified approach for evaluation of hepatic drug-oxidizing capacity with a simultaneous measurement of caffeine and its primary demethylated metabolites in carbon tetrachloride-intoxicated rats.
Topics: Administration, Oral; Animals; Caffeine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced L | 1992 |
A model of cytochrome P-450-centered hepatic dysfunction in drug metabolism induced by cobalt-protoporphyrin administration.
Topics: Aminopyrine; Animals; Breath Tests; Caffeine; Carbon Dioxide; Chemical and Drug Induced Liver Injury | 1989 |
[Biotransformation in patients following Depressan-induced hepatitis].
Topics: Adult; Aged; Biotransformation; Caffeine; Chemical and Drug Induced Liver Injury; Dihydralazine; Fem | 1989 |
Acetaminophen-induced hepatotoxicity: antagonistic action of caffeine in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Binding Sites; Cadmium; C | 1987 |
Increased hepatotoxicity of acetaminophen by concomitant administration of caffeine in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Dr | 1985 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced L | 1973 |
Dependance on analgesics in analgesic nephropathy.
Topics: Adult; Aged; Analgesics; Aspirin; Caffeine; Chemical and Drug Induced Liver Injury; Codeine; Female; | 1973 |
The toxicity of phenacetin at the range of the oral LD50(100 days) in albino rats.
Topics: Animals; Asthenia; Ataxia; Caffeine; Chemical and Drug Induced Liver Injury; Cyanosis; Dehydration; | 1968 |