caffeine has been researched along with Ache in 176 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study evaluated the analgesic effects of low-level laser therapy (LLLT) and paracetamol-caffeine in controlling orthodontic pain induced by elastomeric separators, as well as changes in oral health-related quality of life (OHRQoL)." | 9.51 | The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial. ( Al-Sabbagh, R; Hajeer, MY; Murad, RMT; Owayda, AM, 2022) |
| "Caffeine infusion significantly reduced pain and drowsiness, but the reduction did not reach clinical significance in patients with advanced cancer undergoing opioid therapy." | 9.17 | Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial. ( Ahn, HY; Bae, WK; Cho, K; Choi, YS; Kim, YS; Lee, JH; Oh, SC; Seo, AR; Suh, SY, 2013) |
| "Caffeine does not have an analgesic effect on ischemic pain, either by a peripheral or by a central site of action." | 9.14 | Caffeine does not attenuate experimentally induced ischemic pain in healthy subjects. ( Dellermalm, J; Grass, S; Segerdahl, M, 2009) |
| "Caffeine increased the pain-free walking distance by 20." | 9.14 | Randomized double-blind placebo-controlled crossover study of caffeine in patients with intermittent claudication. ( Jensen, MB; Lindholt, JS; Madsen, MR; Momsen, AH; Norager, CB; Vestersgaard-Andersen, T, 2010) |
| "This experiment examined the effect of a moderate dose of caffeine on quadriceps muscle pain during a bout of high-intensity cycling in low- versus high-caffeine-consuming males." | 9.14 | Effect of caffeine on quadriceps muscle pain during acute cycling exercise in low versus high caffeine consumers. ( Arngrimsson, SA; Broglio, SP; Gliottoni, RC; Meyers, JR; Motl, RW, 2009) |
| "This experiment examined the effect of a moderate dose of caffeine on perceptions of leg-muscle pain during a bout of high-intensity cycling exercise and the role of anxiety sensitivity in the hypoalgesic effect of caffeine on muscle pain during exercise." | 9.13 | Effect of caffeine on leg-muscle pain during intense cycling exercise: possible role of anxiety sensitivity. ( Gliottoni, RC; Motl, RW, 2008) |
| " This experiment found that caffeine (equal to approximately 2 cups of brewed coffee) could produce a large reduction in pain resulting from eccentric exercise-induced, delayed-onset muscle injury." | 9.12 | Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise. ( Dudley, GA; Maridakis, V; McCully, KK; O'Connor, PJ, 2007) |
| "This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain and blood pressure during moderate intensity cycling exercise." | 9.11 | Dose-dependent effect of caffeine on reducing leg muscle pain during cycling exercise is unrelated to systolic blood pressure. ( Broglio, SP; Ely, MR; Motl, RW; O'Connor, PJ, 2004) |
| "In a double-blind, randomized controlled trial among 500 post-partum patients experiencing moderate to severe pain, a single oral dose of an aspirin/caffeine combination (800 mg aspirin, 65 mg caffeine) provided significantly more pain relief at 2 hours than did a higher dose of an acetaminophen/aspirin combination (648 mg acetaminophen, 648 mg aspirin) and a higher dose of acetaminophen alone (1000 mg acetaminophen)." | 9.05 | A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain. ( Rubin, A; Winter, L, 1984) |
| "Thirty-two papers, with 49 different experimental studies were identified (12 pain, 21 nicotine, 7 caffeine, 9 alcohol)." | 8.85 | Identifying experimental methods to determine the effect of pain on attention: a review of pain, caffeine, alcohol and nicotine studies. ( Eccleston, C; Keogh, E; Moore, DJ, 2009) |
| "Results of this study completed with community-dwelling adults revealed that individuals who habitually consume greater amounts of caffeine as part of their daily diets demonstrate diminished sensitivity to painful stimuli in a laboratory setting." | 7.88 | Higher habitual dietary caffeine consumption is related to lower experimental pain sensitivity in a community-based sample. ( Aroke, EN; Cable, ST; Goodin, BR; Overstreet, DS; Penn, TM, 2018) |
| "Many human and animal studies have shown the influence of nicotine and caffeine on pain perception and processing." | 7.80 | Influences of smoking and caffeine consumption on trigeminal pain processing. ( Diener, HC; Heber, A; Holle, D; Katsarava, Z; Naegel, S; Obermann, M, 2014) |
| "Caffeine (CAF) ingestion may enhance endurance exercise by lowering perceived exertion (RPE) and muscle pain." | 7.77 | Caffeine lowers muscle pain during exercise in hot but not cool environments. ( Anderson, JM; Armstrong, LE; Casa, DJ; Emmanuel, H; Ganio, MS; Johnson, EC; Lopez, RM; Maresh, CM; Stearns, RL; Volek, JS, 2011) |
| "This study compared effects of the mu opioid receptor agonist morphine (an acknowledged analgesic), the dopamine receptor antagonist haloperidol (a non-analgesic sedative), the adenosine receptor antagonist caffeine (a non-analgesic stimulant) and the neurokinin-1 receptor antagonist CJ 11,974-01 (a candidate analgesic) on acetic acid-induced writhing (a traditional pain-stimulated behavior) and acetic acid-induced suppression of locomotor activity (a pain-depressed behavior) in male ICR mice." | 7.75 | Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice. ( Adams, C; Bilsky, EJ; Cormier, J; Dunbar, C; Mercer, H; Negus, SS; Stevenson, GW, 2009) |
| "Caffeine, used in many pain medications as an adjuvant analgesic, is an adenosine A1 and A2A receptor antagonist." | 7.73 | Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury. ( Fredholm, BB; Hao, JX; Wiesenfeld-Hallin, Z; Wu, WP; Xu, XJ, 2006) |
| "This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions." | 7.71 | Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001) |
| "Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)." | 7.70 | Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999) |
| "In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain." | 7.70 | Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000) |
| "The ability of caffeine to potentiate the analgesic effect of aspirin was studied in the pain-induced functional impairment model in the rat." | 7.69 | Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Castillo-Méndez, MS; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ, 1994) |
| "The analgesic activities of paracetamol (100, 178, 316 and 562 mg kg-1), caffeine (10, 18, 32 and 56 mg kg-1) and combinations of these doses were tested on a pain-induced functional impairment model in the rat." | 7.68 | Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ; Salazar, LA; Villarreal, JE, 1993) |
| "" The hypothesis suggesting that abstention from coffee and caffeine consumption eliminates breast pain and resolves breast nodules was based on an uncontrolled clinical study." | 7.67 | Prospective study of "fibrocystic breast disease" and caffeine consumption. ( Heyden, S; Muhlbaier, LH, 1984) |
| "The effects of methylxanthines (caffeine, theophylline and theobromine) on the symptoms associated with fibrocystic breast disease were studied in 147 patients." | 7.67 | Caffeine restriction as initial treatment for breast pain. ( Russell, LC, 1989) |
| "In a pain management program (200 patients), a group of daily users of oxycodone compound (29 patients) and a subgroup who were taking a "high dose" of oxycodone compound (13 patients) were compared with a group of 171 non-users of oxycodone compound." | 7.66 | Problems with the use of oxycodone compound in patients with chronic pain. ( Maruta, T; Swanson, DW, 1981) |
| "Thalidomide was introduced as a sedative and antiemetic agent to the European market in the late 1950s." | 6.42 | [Novel potential uses of thalidomide in the management of pain? A review of the literature]. ( Bruera, E; Peuckmann, V; Strumpf, M; Zenz, M, 2003) |
| "These data do not support the hypothesis that occasional intake of a small dose of caffeine as part of pain medication imposes a health risk due to vital sign changes." | 5.69 | Lack of Evidence for Blood Pressure Effects of Caffeine Added to Ibuprofen. ( Lampert, A; Lange, R; Weiser, T, 2023) |
| "This study evaluated the analgesic effects of low-level laser therapy (LLLT) and paracetamol-caffeine in controlling orthodontic pain induced by elastomeric separators, as well as changes in oral health-related quality of life (OHRQoL)." | 5.51 | The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial. ( Al-Sabbagh, R; Hajeer, MY; Murad, RMT; Owayda, AM, 2022) |
| "Caffeine is able to increase the effect of rac-Flur in the arthritic gout-type pain in rats." | 5.43 | Antinociceptive Effect of Racemic Flurbiprofen and Caffeine Co-Administration in an Arthritic Gout-Type Pain in Rats. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; Liévano-Reyes, R; López-Muñoz, FJ; Pérez-Méndez, HI; Solís-Oba, A, 2016) |
| "Genital hyperesthesia is more recognized in women but may affect men." | 5.35 | Caffeine-related genital skin pain. ( Markos, AR, 2008) |
| "This review was designated to evaluate the efficacy of parenteral ketorolac in treating acute migraine headache." | 5.22 | Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis. ( Abu Bakar, MA; Baharuddin, KA; Norhayati, MN; Nurathirah, MN; Yazid, MB, 2022) |
| "Caffeine infusion significantly reduced pain and drowsiness, but the reduction did not reach clinical significance in patients with advanced cancer undergoing opioid therapy." | 5.17 | Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial. ( Ahn, HY; Bae, WK; Cho, K; Choi, YS; Kim, YS; Lee, JH; Oh, SC; Seo, AR; Suh, SY, 2013) |
| "Painful laser stimuli were delivered to 20 healthy subjects before and after administration of a drink with 0 or 4 mg/kg caffeine." | 5.15 | Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo. ( Bjørkedal, E; Flaten, MA, 2011) |
| "Caffeine does not have an analgesic effect on ischemic pain, either by a peripheral or by a central site of action." | 5.14 | Caffeine does not attenuate experimentally induced ischemic pain in healthy subjects. ( Dellermalm, J; Grass, S; Segerdahl, M, 2009) |
| "Caffeine increased the pain-free walking distance by 20." | 5.14 | Randomized double-blind placebo-controlled crossover study of caffeine in patients with intermittent claudication. ( Jensen, MB; Lindholt, JS; Madsen, MR; Momsen, AH; Norager, CB; Vestersgaard-Andersen, T, 2010) |
| "This experiment examined the effect of a moderate dose of caffeine on quadriceps muscle pain during a bout of high-intensity cycling in low- versus high-caffeine-consuming males." | 5.14 | Effect of caffeine on quadriceps muscle pain during acute cycling exercise in low versus high caffeine consumers. ( Arngrimsson, SA; Broglio, SP; Gliottoni, RC; Meyers, JR; Motl, RW, 2009) |
| "This experiment examined the effect of a moderate dose of caffeine on perceptions of leg-muscle pain during a bout of high-intensity cycling exercise and the role of anxiety sensitivity in the hypoalgesic effect of caffeine on muscle pain during exercise." | 5.13 | Effect of caffeine on leg-muscle pain during intense cycling exercise: possible role of anxiety sensitivity. ( Gliottoni, RC; Motl, RW, 2008) |
| " This experiment found that caffeine (equal to approximately 2 cups of brewed coffee) could produce a large reduction in pain resulting from eccentric exercise-induced, delayed-onset muscle injury." | 5.12 | Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise. ( Dudley, GA; Maridakis, V; McCully, KK; O'Connor, PJ, 2007) |
| "The aim of this study was to determine the analgesic effect of acetaminophen compared to a combination of both caffeine and acetaminophen or caffeine alone using tonic and phasic pain stimulation." | 5.12 | Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen. ( Beisel, A; Brune, K; Clarke, G; Grattan, T; Kobal, G; Mueller, C; Renner, B; Werner, U, 2007) |
| "This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain and blood pressure during moderate intensity cycling exercise." | 5.11 | Dose-dependent effect of caffeine on reducing leg muscle pain during cycling exercise is unrelated to systolic blood pressure. ( Broglio, SP; Ely, MR; Motl, RW; O'Connor, PJ, 2004) |
| "A single-blind, randomized clinical trial of 56 female subjects was conducted to determine whether decreased consumption of caffeine decreases breast pain/tenderness or nodularity in patients with suspected benign proliferative breast disease." | 5.06 | The effect of decreased caffeine consumption on benign proliferative breast disease: a randomized clinical trial. ( Allen, SS; Froberg, DG, 1987) |
| "In a double-blind, randomized controlled trial among 500 post-partum patients experiencing moderate to severe pain, a single oral dose of an aspirin/caffeine combination (800 mg aspirin, 65 mg caffeine) provided significantly more pain relief at 2 hours than did a higher dose of an acetaminophen/aspirin combination (648 mg acetaminophen, 648 mg aspirin) and a higher dose of acetaminophen alone (1000 mg acetaminophen)." | 5.05 | A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain. ( Rubin, A; Winter, L, 1984) |
| "Paracetamol/caffeine (1,000 mg/130 mg) is effective and safe for use in acute management of pain." | 4.86 | A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine. ( Day, R; Graham, G; Palmer, H; Williams, K, 2010) |
| "Thirty-two papers, with 49 different experimental studies were identified (12 pain, 21 nicotine, 7 caffeine, 9 alcohol)." | 4.85 | Identifying experimental methods to determine the effect of pain on attention: a review of pain, caffeine, alcohol and nicotine studies. ( Eccleston, C; Keogh, E; Moore, DJ, 2009) |
| "Potentially remediable risk factors include frequency of migraine attacks, obesity, excessive use of medications containing opioids and barbiturates, caffeine overuse, stressful life events, depression, sleep disorders and cutaneous allodynia." | 4.85 | What predicts the change from episodic to chronic migraine? ( Bigal, ME; Lipton, RB, 2009) |
| " Some investigations did find associations between breast pain and premenstrual syndrome, fibrocystic breast disease, and caffeine intake." | 4.81 | Benign breast pain in women: a practical approach to evaluation and treatment. ( Norlock, FE, 2002) |
| "A prediction model development study was completed using the 2006 American Migraine Prevalence and Prevention Study survey, from participants who were aged ≥18, met criteria and headache day frequency for episodic migraine, did not take prescription medication for migraine, and used ≥1 of the following acute migraine medication classes: acetaminophen, aspirin, NSAIDs, or caffeine containing combination products (CCP)." | 4.12 | Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study. ( Armand, CE; Buse, DC; Ezzati, A; Fanning, KM; Lipton, RB; Martin, VT; Pavlovic, JM; Reed, ML, 2022) |
| "The purine alkaloid caffeine is the most widely consumed psychostimulant drug in the world and has multiple beneficial pharmacological activities, for example, in neurodegenerative diseases." | 4.02 | The Medicinal Chemistry of Caffeine. ( Arifi, S; Faudone, G; Merk, D, 2021) |
| "Results of this study completed with community-dwelling adults revealed that individuals who habitually consume greater amounts of caffeine as part of their daily diets demonstrate diminished sensitivity to painful stimuli in a laboratory setting." | 3.88 | Higher habitual dietary caffeine consumption is related to lower experimental pain sensitivity in a community-based sample. ( Aroke, EN; Cable, ST; Goodin, BR; Overstreet, DS; Penn, TM, 2018) |
| "Acetaminophen (APAP) is a widely used analgesic drug that is frequently co-administered with caffeine (CAF) in the treatment of pain." | 3.85 | Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans. ( Baier, V; Blank, LM; Cordes, H; Kuepfer, L; Thiel, C, 2017) |
| "Many human and animal studies have shown the influence of nicotine and caffeine on pain perception and processing." | 3.80 | Influences of smoking and caffeine consumption on trigeminal pain processing. ( Diener, HC; Heber, A; Holle, D; Katsarava, Z; Naegel, S; Obermann, M, 2014) |
| "Caffeine (CAF) ingestion may enhance endurance exercise by lowering perceived exertion (RPE) and muscle pain." | 3.77 | Caffeine lowers muscle pain during exercise in hot but not cool environments. ( Anderson, JM; Armstrong, LE; Casa, DJ; Emmanuel, H; Ganio, MS; Johnson, EC; Lopez, RM; Maresh, CM; Stearns, RL; Volek, JS, 2011) |
| "Oxcarbazepine is an anticonvulsant drug that has been explored as a novel therapeutic agent to treat neuropathic pain in humans." | 3.76 | Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice. ( Fredholm, BB; Reid, AR; Sawynok, J, 2010) |
| "This study compared effects of the mu opioid receptor agonist morphine (an acknowledged analgesic), the dopamine receptor antagonist haloperidol (a non-analgesic sedative), the adenosine receptor antagonist caffeine (a non-analgesic stimulant) and the neurokinin-1 receptor antagonist CJ 11,974-01 (a candidate analgesic) on acetic acid-induced writhing (a traditional pain-stimulated behavior) and acetic acid-induced suppression of locomotor activity (a pain-depressed behavior) in male ICR mice." | 3.75 | Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice. ( Adams, C; Bilsky, EJ; Cormier, J; Dunbar, C; Mercer, H; Negus, SS; Stevenson, GW, 2009) |
| "Both anandamide and adenosine have significant roles in pain mechanisms, but no data are available concerning their interaction at the spinal level." | 3.75 | The antinociceptive interaction of anandamide and adenosine at the spinal level. ( Benedek, G; Horvath, G; Kekesi, G; Nagy, E; Tuboly, G, 2009) |
| "Amitriptyline is used to treat neuropathic pain in humans." | 3.74 | Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors. ( Fredholm, BB; Reid, AR; Sawynok, J, 2008) |
| "Caffeine, used in many pain medications as an adjuvant analgesic, is an adenosine A1 and A2A receptor antagonist." | 3.73 | Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury. ( Fredholm, BB; Hao, JX; Wiesenfeld-Hallin, Z; Wu, WP; Xu, XJ, 2006) |
| "The fixed combination of aspirin, paracetamol (acetaminophen) and caffeine has been used successfully to treat different kinds of pain including migraine attacks." | 3.73 | Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine. ( Aicher, B; Akundi, RS; Candelario-Jalil, E; Fiebich, BL; Finkenzeller, G; Heinzmann, M; Hüll, M; Knörle, R; Mantovani, M; Schnierle, P, 2006) |
| "This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions." | 3.71 | Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001) |
| "Caffeine potentiation of ketorolac-induced antinociception in the pain-induced functional impairment model in rats was assessed." | 3.70 | Effect of coadministration of caffeine and either adenosine agonists or cyclic nucleotides on ketorolac analgesia. ( Aguirre-Bañuelos, P; Castañeda-Hernández, G; Granados-Soto, V; López-Muñoz, FJ, 1999) |
| "Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)." | 3.70 | Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999) |
| "Spinal administration of an adenosine kinase inhibitor, alone or in combination with an adenosine deaminase inhibitor, produces antinociception in inflammatory pain tests." | 3.70 | Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor. ( Poon, A; Sawynok, J, 1999) |
| "In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain." | 3.70 | Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000) |
| "The ability of caffeine to potentiate the analgesic effect of aspirin was studied in the pain-induced functional impairment model in the rat." | 3.69 | Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Castillo-Méndez, MS; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ, 1994) |
| "The analgesic activities of paracetamol (100, 178, 316 and 562 mg kg-1), caffeine (10, 18, 32 and 56 mg kg-1) and combinations of these doses were tested on a pain-induced functional impairment model in the rat." | 3.68 | Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ; Salazar, LA; Villarreal, JE, 1993) |
| "" The hypothesis suggesting that abstention from coffee and caffeine consumption eliminates breast pain and resolves breast nodules was based on an uncontrolled clinical study." | 3.67 | Prospective study of "fibrocystic breast disease" and caffeine consumption. ( Heyden, S; Muhlbaier, LH, 1984) |
| "The effects of methylxanthines (caffeine, theophylline and theobromine) on the symptoms associated with fibrocystic breast disease were studied in 147 patients." | 3.67 | Caffeine restriction as initial treatment for breast pain. ( Russell, LC, 1989) |
| "In a pain management program (200 patients), a group of daily users of oxycodone compound (29 patients) and a subgroup who were taking a "high dose" of oxycodone compound (13 patients) were compared with a group of 171 non-users of oxycodone compound." | 3.66 | Problems with the use of oxycodone compound in patients with chronic pain. ( Maruta, T; Swanson, DW, 1981) |
| "A painful writhing syndrome is produced by aconitine when given intraperitoneally." | 3.66 | Aconitine-induced writhing as a method for assessing aspirin-like analgesic activity. ( Bhalla, TN; Bhargava, KP, 1980) |
| "Caffeine has potential properties to counteract the central effects of morphine." | 2.70 | Effects of caffeine as an adjuvant to morphine in advanced cancer patients. A randomized, double-blind, placebo-controlled, crossover study. ( Casuccio, A; Mercadante, S; Serretta, R, 2001) |
| "The aim of the study was to investigate whether the analgesic effect of propyphenazone (PROP) was increased when it was administered in combination with caffeine (CAFF)." | 2.68 | Analgesic effects of propyphenazone in comparison to its combination with caffeine. ( Hummel, T; Kobal, G; Kraetsch, HG; Kussat, R; Lötsch, J, 1996) |
| "Caffeine is a very common CNS stimulant that has been of interest to physiologists because of its direct effects on skeletal muscle in vitro, as well as ergogenic effects on laboratory tests of human performance." | 2.43 | The influence of caffeine on voluntary muscle activation. ( Kalmar, JM, 2005) |
| "Thalidomide was introduced as a sedative and antiemetic agent to the European market in the late 1950s." | 2.42 | [Novel potential uses of thalidomide in the management of pain? A review of the literature]. ( Bruera, E; Peuckmann, V; Strumpf, M; Zenz, M, 2003) |
| " Long term use produces tolerance to some of the pharmacological effects." | 2.39 | Pharmacological rationale for the clinical use of caffeine. ( Sawynok, J, 1995) |
| "The consequences of chronic insufficient sleep for health remain uncertain." | 1.46 | Decreased alertness due to sleep loss increases pain sensitivity in mice. ( Alexandre, C; Ferreira, A; Latremoliere, A; Miracca, G; Scammell, TE; Woolf, CJ; Yamamoto, M, 2017) |
| "Caffeine is able to increase the effect of rac-Flur in the arthritic gout-type pain in rats." | 1.43 | Antinociceptive Effect of Racemic Flurbiprofen and Caffeine Co-Administration in an Arthritic Gout-Type Pain in Rats. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; Liévano-Reyes, R; López-Muñoz, FJ; Pérez-Méndez, HI; Solís-Oba, A, 2016) |
| " The potential efficacy of these MN for paediatric dosing was investigated via in vitro and in vivo studies." | 1.42 | Potential of hydrogel-forming and dissolving microneedles for use in paediatric populations. ( Caffarel-Salvador, E; Donnelly, RF; McCarthy, HO; McElnay, JC; Mooney, K; Tuan-Mahmood, TM; Woolfson, AD, 2015) |
| "Genital hyperesthesia is more recognized in women but may affect men." | 1.35 | Caffeine-related genital skin pain. ( Markos, AR, 2008) |
| " Dopamine-deficient mice have a rightward shift in the dose-response curve to morphine on the tail-flick test (a pain sensitivity assay), suggesting either a decreased sensitivity to the analgesic effects of morphine and/or basal hyperalgesia." | 1.33 | Morphine reward in dopamine-deficient mice. ( Hnasko, TS; Palmiter, RD; Sotak, BN, 2005) |
| "When caffeine was administered prior to MDMA, a potentiation of locomotor activity was observed, which consisted in an increase in maximal values and in a prolonged time of activity." | 1.33 | Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug. ( Camarasa, J; Escubedo, E; Pubill, D, 2006) |
| "According to the degree of importance to the combined analgesic effect, Ace > Caf > Bul; Ace showed a significant dose-response relationship, whereas in Caf and Bul, this relationship was not apparent." | 1.31 | Quantitative design of optimal analgesic combination of acetaminophen, caffeine, and butalbital. ( Gui, CQ; Sun, RY; Wang, XW; Zheng, QS, 2001) |
| "Caffeine was used as a partial control for the lithium." | 1.30 | Oscillatory effects of repeated morphine on shock-induced hypoalgesia and beta-endorphin. ( Antelman, SM; Austin, MC; Caggiula, AR; Edwards, DJ; Fowler, H; Gershon, S; Kucinski, BJ, 1998) |
| "Caffeine did not produce an anti-inflammatory effect as determined by hindpaw plethysmometry, suggesting that antinociception was not secondary to an anti-inflammatory action." | 1.29 | Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms. ( Doak, GJ; Reid, AR; Sawynok, J, 1995) |
| " In each series of experiments, dose-response curves for morphine (probit analysis) were determined with and without the addition of caffeine (30 mg X kg-1)." | 1.27 | Morphine--caffeine analgesic interaction in rats. ( Bradley, EL; Brown, PT; Kissin, I; Person, DL; Vinik, HR; Xavier, AV, 1985) |
| "Retropharyngeal calcific tendonitis is a not-infrequent cause of atraumatic neck pain." | 1.27 | Calcific tendonitis of the longus colli muscle: a cause of atraumatic neck pain. ( Widlus, DM, 1985) |
| "Phenacetin was removed from this preparation in 1970 and replaced by an approximately equal amount of ASA (ACC)." | 1.25 | Letter: The clinical course of patients with analgesic nephropathy. ( Gault, MH, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 81 (46.02) | 18.7374 |
| 1990's | 29 (16.48) | 18.2507 |
| 2000's | 35 (19.89) | 29.6817 |
| 2010's | 25 (14.20) | 24.3611 |
| 2020's | 6 (3.41) | 2.80 |
| Authors | Studies |
|---|---|
| Abo-Salem, OM | 1 |
| Hayallah, AM | 1 |
| Bilkei-Gorzo, A | 1 |
| Filipek, B | 1 |
| Zimmer, A | 1 |
| Müller, CE | 1 |
| Alfaraj, R | 1 |
| Alabdulsalam, Z | 1 |
| Alfaraj, Z | 1 |
| Alsunni, H | 1 |
| Alhawaj, H | 1 |
| Omar, O | 1 |
| Abuohashish, H | 1 |
| Owayda, AM | 1 |
| Hajeer, MY | 1 |
| Murad, RMT | 1 |
| Al-Sabbagh, R | 1 |
| Nurathirah, MN | 1 |
| Yazid, MB | 1 |
| Norhayati, MN | 1 |
| Baharuddin, KA | 1 |
| Abu Bakar, MA | 1 |
| Lampert, A | 1 |
| Lange, R | 1 |
| Weiser, T | 1 |
| Ezzati, A | 1 |
| Fanning, KM | 1 |
| Buse, DC | 1 |
| Pavlovic, JM | 1 |
| Armand, CE | 1 |
| Reed, ML | 1 |
| Martin, VT | 1 |
| Lipton, RB | 2 |
| Faudone, G | 1 |
| Arifi, S | 1 |
| Merk, D | 1 |
| Alexandre, C | 1 |
| Latremoliere, A | 1 |
| Ferreira, A | 1 |
| Miracca, G | 1 |
| Yamamoto, M | 1 |
| Scammell, TE | 1 |
| Woolf, CJ | 1 |
| Fujita, T | 1 |
| Feng, C | 1 |
| Takano, T | 1 |
| Overstreet, DS | 1 |
| Penn, TM | 1 |
| Cable, ST | 1 |
| Aroke, EN | 1 |
| Goodin, BR | 1 |
| Kuntz, JL | 1 |
| Firemark, A | 1 |
| Schneider, J | 1 |
| Henninger, M | 1 |
| Bok, K | 1 |
| Naleway, A | 1 |
| Suh, SY | 1 |
| Choi, YS | 1 |
| Oh, SC | 1 |
| Kim, YS | 1 |
| Cho, K | 1 |
| Bae, WK | 1 |
| Lee, JH | 1 |
| Seo, AR | 1 |
| Ahn, HY | 1 |
| Holle, D | 1 |
| Heber, A | 1 |
| Naegel, S | 1 |
| Diener, HC | 1 |
| Katsarava, Z | 1 |
| Obermann, M | 1 |
| Zhang, YG | 1 |
| Shen, L | 1 |
| Xu, L | 1 |
| Huang, YG | 1 |
| Quinlivan, A | 1 |
| Irwin, C | 1 |
| Grant, GD | 1 |
| Anoopkumar-Dukie, S | 1 |
| Skinner, T | 1 |
| Leveritt, M | 1 |
| Desbrow, B | 1 |
| Caffarel-Salvador, E | 1 |
| Tuan-Mahmood, TM | 1 |
| McElnay, JC | 1 |
| McCarthy, HO | 1 |
| Mooney, K | 1 |
| Woolfson, AD | 1 |
| Donnelly, RF | 1 |
| Carrillo-Munguía, N | 1 |
| González-Trujano, ME | 1 |
| Huerta, M | 1 |
| Trujillo, X | 1 |
| Díaz-Reval, MI | 1 |
| Stadheim, HK | 1 |
| Nossum, EM | 1 |
| Olsen, R | 1 |
| Spencer, M | 1 |
| Jensen, J | 1 |
| Liévano-Reyes, R | 1 |
| Pérez-Méndez, HI | 1 |
| Solís-Oba, A | 1 |
| Jaramillo-Morales, OA | 1 |
| Espinosa-Juárez, JV | 1 |
| López-Muñoz, FJ | 5 |
| Thiel, C | 1 |
| Cordes, H | 1 |
| Baier, V | 1 |
| Blank, LM | 1 |
| Kuepfer, L | 1 |
| Sawynok, J | 12 |
| Reid, AR | 5 |
| Fredholm, BB | 3 |
| Jenkins, NT | 1 |
| Trilk, JL | 1 |
| Singhal, A | 1 |
| O'Connor, PJ | 3 |
| Cureton, KJ | 1 |
| Tuboly, G | 1 |
| Kekesi, G | 1 |
| Nagy, E | 1 |
| Benedek, G | 1 |
| Horvath, G | 1 |
| Bigal, ME | 1 |
| Gliottoni, RC | 2 |
| Meyers, JR | 1 |
| Arngrimsson, SA | 1 |
| Broglio, SP | 2 |
| Motl, RW | 3 |
| Dickie, A | 1 |
| Tabasam, G | 1 |
| Tashani, O | 1 |
| Marchant, P | 1 |
| Johnson, MI | 1 |
| Stevenson, GW | 1 |
| Cormier, J | 1 |
| Mercer, H | 1 |
| Adams, C | 1 |
| Dunbar, C | 1 |
| Negus, SS | 1 |
| Bilsky, EJ | 1 |
| Dellermalm, J | 1 |
| Segerdahl, M | 1 |
| Grass, S | 1 |
| Davis, JK | 1 |
| Green, JM | 1 |
| Moore, DJ | 1 |
| Keogh, E | 1 |
| Eccleston, C | 1 |
| Cheng, LZ | 1 |
| Lü, N | 1 |
| Zhang, YQ | 1 |
| Zhao, ZQ | 1 |
| Cressey, D | 1 |
| Palmer, H | 1 |
| Graham, G | 1 |
| Williams, K | 1 |
| Day, R | 1 |
| Momsen, AH | 1 |
| Jensen, MB | 1 |
| Norager, CB | 1 |
| Madsen, MR | 1 |
| Vestersgaard-Andersen, T | 1 |
| Lindholt, JS | 1 |
| Ganio, MS | 1 |
| Johnson, EC | 1 |
| Lopez, RM | 1 |
| Stearns, RL | 1 |
| Emmanuel, H | 1 |
| Anderson, JM | 1 |
| Casa, DJ | 1 |
| Maresh, CM | 1 |
| Volek, JS | 1 |
| Armstrong, LE | 1 |
| Bjørkedal, E | 1 |
| Flaten, MA | 1 |
| Shaw, KD | 1 |
| Amstutz, U | 1 |
| Jimenez-Mendez, R | 1 |
| Ross, CJ | 1 |
| Carleton, BC | 1 |
| Habib, M | 1 |
| Waheed, I | 1 |
| Leutgeb, U | 1 |
| Martus, P | 1 |
| Manfredi, PL | 1 |
| Gonzales, GR | 1 |
| Peuckmann, V | 1 |
| Strumpf, M | 1 |
| Zenz, M | 1 |
| Bruera, E | 1 |
| CALDWELL, WG | 2 |
| MEYERS, B | 2 |
| NICHTERN, S | 1 |
| SZIRMAI, E | 1 |
| HEADLEY, CR | 1 |
| KOSLIN, AJ | 1 |
| MINK, E | 1 |
| KLUGE, K | 1 |
| VINCI, SL | 1 |
| EIGELSREITER, H | 1 |
| ZEGERS, RT | 1 |
| CAHILL, MC | 1 |
| DELLOMODARME, G | 1 |
| Herrero, JF | 1 |
| Romero-Sandoval, EA | 1 |
| Gaitan, G | 1 |
| Mazario, J | 1 |
| Ely, MR | 1 |
| FAHRNI, R | 1 |
| Sekhon, I | 1 |
| Munjal, S | 1 |
| Croker, B | 1 |
| Johnson, RJ | 1 |
| Ejaz, AA | 1 |
| Kalmar, JM | 1 |
| Hnasko, TS | 1 |
| Sotak, BN | 1 |
| Palmiter, RD | 1 |
| Godfrey, L | 1 |
| Yan, L | 1 |
| Clarke, GD | 1 |
| Ledent, C | 2 |
| Kitchen, I | 1 |
| Hourani, SM | 1 |
| Fiebich, BL | 1 |
| Candelario-Jalil, E | 1 |
| Mantovani, M | 1 |
| Heinzmann, M | 1 |
| Akundi, RS | 1 |
| Hüll, M | 1 |
| Knörle, R | 1 |
| Schnierle, P | 1 |
| Finkenzeller, G | 1 |
| Aicher, B | 2 |
| Vuckovic, S | 1 |
| Tomic, M | 1 |
| Stepanovic-Petrovic, R | 1 |
| Ugresic, N | 1 |
| Prostran, M | 1 |
| Boskovic, B | 1 |
| Wu, WP | 1 |
| Hao, JX | 1 |
| Wiesenfeld-Hallin, Z | 1 |
| Xu, XJ | 1 |
| Camarasa, J | 1 |
| Pubill, D | 1 |
| Escubedo, E | 1 |
| Maridakis, V | 1 |
| Dudley, GA | 1 |
| McCully, KK | 1 |
| Renner, B | 1 |
| Clarke, G | 1 |
| Grattan, T | 1 |
| Beisel, A | 1 |
| Mueller, C | 1 |
| Werner, U | 1 |
| Kobal, G | 2 |
| Brune, K | 1 |
| Daly, JW | 1 |
| Markos, AR | 1 |
| Edmondson, HD | 1 |
| Bradshaw, AJ | 1 |
| Perlík, F | 1 |
| Laska, EM | 1 |
| Sunshine, A | 1 |
| Mueller, F | 1 |
| Elvers, WB | 1 |
| Siegel, C | 1 |
| Rubin, A | 2 |
| Beaver, WT | 1 |
| Sturrock, RD | 1 |
| Hackenthal, E | 1 |
| Heyden, S | 1 |
| Muhlbaier, LH | 1 |
| Winter, L | 1 |
| Seltzer, S | 1 |
| Roscioni, C | 2 |
| De Ritis, G | 2 |
| Lotti, A | 1 |
| Pozzessere, C | 1 |
| De Rossi, P | 2 |
| Granato, C | 1 |
| Bruno, VF | 1 |
| Nola, P | 1 |
| Morabito, F | 2 |
| De Tommaso, G | 1 |
| Stambaugh, JE | 1 |
| Tejada, F | 1 |
| Trudnowski, RJ | 1 |
| Mayer, TG | 1 |
| Ruoff, GE | 1 |
| Diamanti, E | 1 |
| Lauretti, MC | 1 |
| Maggio, F | 1 |
| Marchionni, G | 1 |
| Mettler, L | 1 |
| Sadighi, R | 1 |
| Maruta, T | 1 |
| Swanson, DW | 1 |
| Bhalla, TN | 1 |
| Bhargava, KP | 1 |
| Hanusz, Z | 1 |
| Marchand, S | 1 |
| Li, J | 1 |
| Charest, J | 1 |
| Doak, GJ | 1 |
| Smith, FL | 1 |
| Stevens, DL | 1 |
| Adachi, K | 1 |
| Castañeda-Hernández, G | 4 |
| Castillo-Méndez, MS | 1 |
| Granados-Soto, V | 4 |
| Flores-Murrieta, FJ | 3 |
| Salazar, LA | 1 |
| Villarreal, JE | 1 |
| Yaksh, TL | 2 |
| Kraupp, O | 1 |
| Schweiger, A | 1 |
| Kraetsch, HG | 1 |
| Hummel, T | 1 |
| Lötsch, J | 1 |
| Kussat, R | 1 |
| Cadier, MA | 1 |
| Hobby, JA | 1 |
| Snyder, SH | 1 |
| Vaugeois, JM | 1 |
| Schiffmann, SN | 1 |
| Pedrazzini, T | 1 |
| El Yacoubi, M | 1 |
| Vanderhaeghen, JJ | 1 |
| Costentin, J | 1 |
| Heath, JK | 1 |
| Vassart, G | 1 |
| Parmentier, M | 1 |
| Ghelardini, C | 1 |
| Galeotti, N | 1 |
| Bartolini, A | 1 |
| Zuev, VP | 1 |
| Minkin, LN | 1 |
| Evglevskaia, IuP | 1 |
| Mashimoto, S | 1 |
| Ushijima, I | 1 |
| Suetsugi, M | 1 |
| Akimoto, T | 1 |
| Watanabe, K | 1 |
| Yamada, M | 1 |
| Kucinski, BJ | 1 |
| Antelman, SM | 1 |
| Caggiula, AR | 1 |
| Fowler, H | 1 |
| Gershon, S | 1 |
| Edwards, DJ | 1 |
| Austin, MC | 1 |
| Khandwala, H | 1 |
| Zhang, Z | 1 |
| Loomis, CW | 1 |
| Reyes, G | 1 |
| Medina, R | 1 |
| Castillo, EF | 1 |
| Herrera, JE | 1 |
| Tinajero, J | 1 |
| Chaves, F | 1 |
| Valdes, B | 1 |
| Esser, MJ | 4 |
| Aguirre-Bañuelos, P | 1 |
| Poon, A | 1 |
| Mercadante, S | 1 |
| Serretta, R | 1 |
| Casuccio, A | 1 |
| Gould, WS | 1 |
| Chase, T | 1 |
| Allen, GV | 1 |
| Zheng, QS | 1 |
| Wang, XW | 1 |
| Gui, CQ | 1 |
| Sun, RY | 1 |
| Norlock, FE | 1 |
| Moertel, CG | 2 |
| Jain, AK | 1 |
| McMahon, FG | 1 |
| Ryan, JR | 1 |
| Unger, D | 1 |
| Richard, W | 1 |
| Krueger, H | 1 |
| Fazel-Madjlessi, A | 1 |
| Plaetschke, I | 1 |
| Smith, MT | 1 |
| Levin, HM | 1 |
| Bare, WW | 1 |
| Berry, FN | 1 |
| Miller, JM | 1 |
| Arushanian, EB | 1 |
| Belozertsev, IuA | 1 |
| Gault, MH | 1 |
| Nielsen, BB | 1 |
| Miaskowski, C | 1 |
| Dibble, SL | 1 |
| Beber, B | 1 |
| Altman, N | 1 |
| McCoy, CB | 1 |
| Bronder, E | 1 |
| Klimpel, A | 1 |
| Pommer, W | 1 |
| Molzahn, M | 1 |
| Bayless, TM | 1 |
| Harris, ML | 1 |
| Sosnowski, M | 1 |
| Stevens, CW | 1 |
| Russell, LC | 1 |
| Zambotti, F | 1 |
| Zonta, N | 1 |
| Tammiso, R | 1 |
| Ferrario, P | 1 |
| Hafner, B | 1 |
| Mantegazza, P | 1 |
| Roy-Byrne, PP | 1 |
| Uhde, TW | 1 |
| Allen, SS | 1 |
| Froberg, DG | 1 |
| Jackson, VP | 1 |
| Lex, AM | 1 |
| Smith, DJ | 1 |
| Høivik, HO | 1 |
| Gundersen, R | 1 |
| Osmundsen, K | 1 |
| Rosaschino, F | 1 |
| Cosentina, R | 2 |
| Castelli, F | 1 |
| Milone, V | 1 |
| Bosco, U | 1 |
| Middleton, RS | 1 |
| Clyne, MJ | 1 |
| Person, DL | 1 |
| Kissin, I | 1 |
| Brown, PT | 1 |
| Xavier, AV | 1 |
| Vinik, HR | 1 |
| Bradley, EL | 1 |
| Widlus, DM | 1 |
| Barciulli, F | 1 |
| Kollmannsberger, A | 1 |
| Miehlke, K | 1 |
| Cantor, M | 1 |
| Bonnamour, C | 1 |
| Peaud, PY | 1 |
| Plauchu, M | 1 |
| Shogam, II | 1 |
| Gabka, J | 1 |
| Schwietzer, CH | 1 |
| Frankendal, B | 1 |
| Kaiser, H | 1 |
| Messerich, J | 1 |
| Ahmann, DL | 1 |
| Taylor, WF | 1 |
| Schwartau, N | 1 |
| Riethe, P | 1 |
| Wilske, E | 1 |
| Bauer, RO | 1 |
| Baptisti, A | 1 |
| Gruber, CM | 1 |
| Grasser, H | 1 |
| Grintzalis, TP | 1 |
| Neumann, H | 1 |
| Scheiber, V | 1 |
| Paalzow, G | 1 |
| Paalzow, L | 1 |
| Siegers, CP | 1 |
| Miller, RR | 1 |
| Feingold, A | 1 |
| Paxinos, J | 1 |
| Wohlzogen, FX | 3 |
| Rölke, HW | 1 |
| Götz, K | 1 |
| Filipescu, A | 1 |
| Spirescu, J | 1 |
| Martins, HT | 1 |
| Batterman, RC | 1 |
| McClure, DA | 1 |
| Raymann, F | 1 |
| Weish, P | 1 |
| Faust, B | 1 |
| Thorpe, P | 1 |
| Shliafer, TP | 1 |
| Haslam, DR | 1 |
| Pepper, H | 1 |
| Lippert, TH | 1 |
| Samaha, M | 1 |
| Rollier, R | 1 |
| Rollier, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Transdermal Microneedle Patch To Enhance Topical Anaesthesia Before Intravenous Line Insertion for Blood Transfusion In Paediatric Thalassemia Patients[NCT05078463] | Phase 2 | 20 participants (Actual) | Interventional | 2021-09-15 | Completed | ||
| Effects of Caffeine in Patients With Intermittent Claudication.[NCT00388128] | Phase 3 | 80 participants (Anticipated) | Interventional | 2006-09-30 | Completed | ||
| Efficacy of Caffeine as an Adjuvant to Opioid Therapy in Cancer Pain: a Randomized, Double-blind, Placebo-controlled Trial[NCT00879775] | Phase 2 | 41 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a higher level of fatigue. (NCT00879775)
Timeframe: two days
| Intervention | scores (Mean) |
|---|---|
| Caffeine | 3.61 |
| Placebo | 3.55 |
Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a better health-related quality of life. (NCT00879775)
Timeframe: two days
| Intervention | scores (Mean) |
|---|---|
| Caffeine | 4.83 |
| Placebo | 4.45 |
Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a higher level of sleep disturbance. (NCT00879775)
Timeframe: two days
| Intervention | scores (Mean) |
|---|---|
| Caffeine | 3.53 |
| Placebo | 3.80 |
Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a higher level of impact of symptom burden to daily life. (NCT00879775)
Timeframe: two days
| Intervention | scores (Mean) | ||||
|---|---|---|---|---|---|
| Daily living | Mood | Work | Interpersonal relationship | Gait ability | |
| Caffeine | 5.17 | 5.61 | 5.56 | 4.61 | 4.39 |
| Placebo | 5.95 | 5.60 | 6.75 | 4.65 | 5.50 |
Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; higher scores represent higher levels of pain, and possible side effects (drowsiness, confusion, nausea) of opioids. (NCT00879775)
Timeframe: two days
| Intervention | scores (Mean) | |||
|---|---|---|---|---|
| Pain | Drowsiness | Confusion | Nausea | |
| Caffeine | 2.22 | 2.83 | 1.89 | 2.28 |
| Placebo | 3.10 | 3.05 | 2.20 | 1.80 |
23 reviews available for caffeine and Ache
| Article | Year |
|---|---|
Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis.
Topics: Caffeine; Dexamethasone; Diclofenac; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Pain; Ph | 2022 |
Regulatory effect of caffeine on the acute and the chronic pain and its possible mechanisms.
Topics: Adenosine; Caffeine; Central Nervous System Stimulants; Chronic Pain; Humans; Pain | 2014 |
What predicts the change from episodic to chronic migraine?
Topics: Analgesics; Caffeine; Central Nervous System Stimulants; Chronic Disease; Clinical Trials as Topic; | 2009 |
Caffeine and anaerobic performance: ergogenic value and mechanisms of action.
Topics: Anaerobic Threshold; Bicycling; Blood Glucose; Caffeine; Catecholamines; Central Nervous System Stim | 2009 |
Identifying experimental methods to determine the effect of pain on attention: a review of pain, caffeine, alcohol and nicotine studies.
Topics: Adult; Attention; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; E | 2009 |
A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Caffeine; Central Nervous System Stimulants; Datab | 2010 |
Methylxanthines and pain.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Interact | 2011 |
Caffeine and pain.
Topics: Analgesics; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Humans; P | 2011 |
Symptomatic uses of caffeine in patients with cancer.
Topics: Analgesics, Opioid; Caffeine; Humans; Neoplasms; Pain | 2003 |
[Novel potential uses of thalidomide in the management of pain? A review of the literature].
Topics: Analgesics; Aspirin; Caffeine; Drug Therapy, Combination; Humans; Pain; Phenacetin; Thalidomide | 2003 |
Antinociception and the new COX inhibitors: research approaches and clinical perspectives.
Topics: Adrenergic Agonists; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Cycloox | 2003 |
The influence of caffeine on voluntary muscle activation.
Topics: Caffeine; Central Nervous System; Evoked Potentials; Humans; Motor Activity; Muscle Contraction; Mus | 2005 |
Caffeine analogs: biomedical impact.
Topics: Alzheimer Disease; Asthma; Biomedical Research; Caffeine; Calcium; Central Nervous System Stimulants | 2007 |
[How important are combined analgesic preparations?].
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Combinations; Humans; Kidney Dis | 1984 |
Foods, and food and drug combinations, responsible for head and neck pain.
Topics: Adult; Alcoholic Beverages; Amygdalin; Cacao; Caffeine; Child; Chronic Disease; Cluster Headache; Dr | 1982 |
Pharmacological rationale for the clinical use of caffeine.
Topics: Animals; Apnea; Caffeine; Central Nervous System; Headache; Humans; Hypotension; Obesity; Pain; Phos | 1995 |
Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action.
Topics: Analgesics; Animals; Caffeine; Drug Synergism; Humans; Pain | 1993 |
[Effectiveness of fixed analgesic combinations exemplified by thomapyrin].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Drug Combinations; Germany; Humans; Pain | 1996 |
Benign breast pain in women: a practical approach to evaluation and treatment.
Topics: Analgesics; Breast Diseases; Caffeine; Central Nervous System Stimulants; Female; Humans; Pain; Prem | 2002 |
Inflammatory bowel disease and irritable bowel syndrome.
Topics: Caffeine; Cholecystectomy; Colon; Colonic Diseases, Functional; Diarrhea; Humans; Ileum; Incidence; | 1990 |
Exogenous factors in panic disorder: clinical and research implications.
Topics: Anxiety Disorders; Caffeine; Cocaine; Diet; Ethanol; Fear; Humans; Life Change Events; Marijuana Abu | 1988 |
[Therapy of sleep disorders in old age].
Topics: Age Factors; Butyrophenones; Caffeine; Cardiac Glycosides; Cerebrovascular Disorders; Chlormethiazol | 1972 |
Propoxyphene hydrochloride. A critical review.
Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headac | 1970 |
46 trials available for caffeine and Ache
| Article | Year |
|---|---|
The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial.
Topics: Acetaminophen; Caffeine; Female; Humans; Low-Level Light Therapy; Male; Malocclusion, Angle Class I; | 2022 |
Lack of Evidence for Blood Pressure Effects of Caffeine Added to Ibuprofen.
Topics: Analgesics, Non-Narcotic; Blood Pressure; Caffeine; Double-Blind Method; Humans; Ibuprofen; Pain; Pa | 2023 |
Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial.
Topics: Aged; Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Chemotherapy, Adjuvant; Doubl | 2013 |
The effects of Red Bull energy drink compared with caffeine on cycling time-trial performance.
Topics: Adult; Athletic Performance; Beverages; Bicycling; Blood Glucose; Caffeine; Cross-Over Studies; Doub | 2015 |
Caffeine improves performance in double poling during acute exposure to 2,000-m altitude.
Topics: Adult; Altitude; Athletic Performance; Caffeine; Catecholamines; Central Nervous System Stimulants; | 2015 |
Ergogenic effects of low doses of caffeine on cycling performance.
Topics: Adult; Bicycling; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Dose-Response Rel | 2008 |
Effect of caffeine on quadriceps muscle pain during acute cycling exercise in low versus high caffeine consumers.
Topics: Adult; Analgesics; Bicycling; Caffeine; Central Nervous System Stimulants; Dose-Response Relationshi | 2009 |
A preliminary investigation into the effect of coffee on hypolagesia associated with transcutaneous electrical nerve stimulation.
Topics: Adult; Caffeine; Coffee; Double-Blind Method; Electric Stimulation; Electric Stimulation Therapy; Fe | 2009 |
Caffeine does not attenuate experimentally induced ischemic pain in healthy subjects.
Topics: Adult; Analgesics; Caffeine; Cross-Over Studies; Double-Blind Method; Female; Humans; Injections, In | 2009 |
Randomized double-blind placebo-controlled crossover study of caffeine in patients with intermittent claudication.
Topics: Aged; Blood Pressure; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over Studies; Do | 2010 |
Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo.
Topics: Adolescent; Adult; Analgesics; Arousal; Caffeine; Central Nervous System Stimulants; Double-Blind Me | 2011 |
Dose-dependent effect of caffeine on reducing leg muscle pain during cycling exercise is unrelated to systolic blood pressure.
Topics: Adult; Blood Pressure; Caffeine; Dose-Response Relationship, Drug; Double-Blind Method; Exercise; He | 2004 |
Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise.
Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Electric Stimul | 2007 |
Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Area Under Curve; Caffeine; Central Nerv | 2007 |
Effect of caffeine on leg-muscle pain during intense cycling exercise: possible role of anxiety sensitivity.
Topics: Adult; Analgesics; Anxiety; Bicycling; Caffeine; Central Nervous System Stimulants; Cross-Over Studi | 2008 |
Analgesia following oral surgery: a comparative study of Solpadeine and a soluble form of dextropropoxyphene napsylate and paracetamol.
Topics: Acetaminophen; Adolescent; Adult; Caffeine; Codeine; Dextropropoxyphene; Drug Combinations; Female; | 1983 |
[Clinical evaluation of analgesics].
Topics: Adult; Aged; Analgesics; Antipyrine; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Comb | 1984 |
Caffeine as an analgesic adjuvant.
Topics: Acetaminophen; Adjuvants, Pharmaceutic; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Dou | 1984 |
Caffeine revisited.
Topics: Adjuvants, Pharmaceutic; Analgesics; Caffeine; Clinical Trials as Topic; Humans; Pain | 1984 |
Distalgesic; safety and efficacy. Efficacy: UK experience.
Topics: Acetaminophen; Apazone; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Drug Combin | 1984 |
A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Double-Blind Method; Drug Combinations; Drug Ev | 1984 |
[Analgesic, antipyretic and anti-rheumatic activity of 2 preparations evaluated in a multicenter clinical trial].
Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Child; Child, Preschool; Clinical Trials | 1982 |
Double-blind comparisons of zomepirac and oxycodone with APC in cancer pain.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug C | 1980 |
Clinical evaluation of zomepirac in the treatment of acute orthopedic pain.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug C | 1980 |
[Comparison of the clinical activity of 2 analgesic formulations].
Topics: Adult; Analgesics; Antipyrine; Caffeine; Clinical Trials as Topic; Drug Combinations; Female; Humans | 1981 |
Effects of caffeine on analgesia from transcutaneous electrical nerve stimulation.
Topics: Adenosine; Adult; Caffeine; Double-Blind Method; Female; Humans; Male; Pain; Pain Measurement; Trans | 1995 |
Analgesic effects of propyphenazone in comparison to its combination with caffeine.
Topics: Administration, Oral; Adult; Analgesia; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroida | 1996 |
Effects of caffeine as an adjuvant to morphine in advanced cancer patients. A randomized, double-blind, placebo-controlled, crossover study.
Topics: Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over Studies; Doub | 2001 |
Relief of pain with oral medications.
Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Aspirin; Caffeine; Clinical Trials as Topic; C | 1976 |
Aspirin and aspirin-caffeine in postpartum pain relief.
Topics: Adolescent; Adult; Aspirin; Caffeine; Clinical Trials as Topic; Double-Blind Method; Drug Combinatio | 1978 |
The influence of 1,3,7-trimethyl-xanthine (caffeine) on the pain-caused dilation of pupil.
Topics: Adult; Caffeine; Humans; Male; Pain; Pupil; Time Factors | 1979 |
Acetaminophen extra strength capsules versus propoxphene compound-65 versus placebo: a double-blind study of effectiveness and safety.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Capsules; Clinical Trials as Topic; Dextropropo | 1975 |
The effect of decreased caffeine consumption on benign proliferative breast disease: a randomized clinical trial.
Topics: Adult; Breast; Breast Diseases; Caffeine; Cell Division; Clinical Trials as Topic; Data Collection; | 1987 |
[Combined analgesics in myalgia of the neck. A double-blind comparison of paracetamol and orphenadrine (Norgesic) and paracetamol and codeine (Paralgin forte) in general practice].
Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double | 1986 |
A comparative study of Propain and a dextropropoxyphene/paracetamol combination analgesic.
Topics: Acetaminophen; Adolescent; Adult; Aged; Caffeine; Codeine; Dextropropoxyphene; Diphenhydramine; Drug | 1985 |
[Clinical testing of a new analgesic combination on cancer patients in chronic pain].
Topics: Adult; Aged; Analgesics; Antipyrine; Aspirin; Caffeine; Clinical Trials as Topic; Dextropropoxyphene | 1973 |
[EMA 3--a phenacetin-free combination with analgesic action].
Topics: Acetaminophen; Adult; Aged; Allyl Compounds; Analgesics; Barbiturates; Caffeine; Clinical Trials as | 1973 |
Relief of pain by oral medications. A controlled evaluation of analgesic combinations.
Topics: Administration, Oral; Analgesics; Aspirin; Azepines; Caffeine; Clinical Trials as Topic; Codeine; De | 1974 |
[Analgetic effects on the stimulus threshold of the human tooth].
Topics: Administration, Oral; Amides; Analgesics; Analysis of Variance; Aspirin; Caffeine; Clinical Trials a | 1974 |
Evaluation of propoxyphene napsylate compound in post partum uterine cramping.
Topics: Administration, Oral; Aspirin; Caffeine; Clinical Trials as Topic; Dextropropoxyphene; Female; Human | 1974 |
[Clinical testing of a new combined analgesic for pain in the dental, jaw-, and facial regions].
Topics: Allyl Compounds; Aminopyrine; Analgesics; Aspirin; Barbiturates; Caffeine; Clinical Trials as Topic; | 1974 |
Propoxyphene hydrochloride. A critical review.
Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headac | 1970 |
Method, design, and analysis of a comparative study of analgetics.
Topics: Acetaminophen; Analgesics; Analysis of Variance; Caffeine; Clinical Trials as Topic; Humans; Pain; P | 1970 |
Method, design, and analysis of a comparative study of analgetics.
Topics: Acetaminophen; Analgesics; Analysis of Variance; Caffeine; Clinical Trials as Topic; Humans; Pain; P | 1970 |
Methodology of analgesic-muscle relaxant evaluation. Experience with orphenadrine citrate compound.
Topics: Adult; Aspirin; Caffeine; Clinical Trials as Topic; Female; Humans; Male; Muscles; Orphenadrine; Pai | 1965 |
An assessment of "Fiorinal" and FIPA in painful conditions of the hands.
Topics: Acetaminophen; Adult; Aged; Analgesics; Analysis of Variance; Arthritis, Rheumatoid; Aspirin; Caffei | 1970 |
108 other studies available for caffeine and Ache
| Article | Year |
|---|---|
Antinociceptive effects of novel A2B adenosine receptor antagonists.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Analgesia; Animals; Caffeine; Drug Synergism; Male; Mi | 2004 |
Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study.
Topics: Anesthetics, Local; Animals; Caffeine; Drug Interactions; Humans; Lidocaine; Pain; Rats; Rats, Wista | 2022 |
Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study.
Topics: Acetaminophen; Caffeine; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Nonprescri | 2022 |
The Medicinal Chemistry of Caffeine.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Chemistry, Pharmaceutical; Glycogen Phosphorylase; Hu | 2021 |
Decreased alertness due to sleep loss increases pain sensitivity in mice.
Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Chronic Diseas | 2017 |
Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia.
Topics: Acupuncture Analgesia; Animals; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; | 2017 |
Higher habitual dietary caffeine consumption is related to lower experimental pain sensitivity in a community-based sample.
Topics: Adult; Aged; Caffeine; Carbonated Beverages; Coffee; Energy Drinks; Feeding Behavior; Female; Humans | 2018 |
Development of an Intervention to Reduce Pain and Prevent Syncope Related to Adolescent Vaccination.
Topics: Adolescent; Breathing Exercises; Caffeine; Child; Drinking Water; Female; Humans; Interviews as Topi | 2019 |
Influences of smoking and caffeine consumption on trigeminal pain processing.
Topics: Adult; Brain Stem; Caffeine; Electric Stimulation; Evoked Potentials; Female; Humans; Male; Pain; Pa | 2014 |
Potential of hydrogel-forming and dissolving microneedles for use in paediatric populations.
Topics: Administration, Cutaneous; Adolescent; Analgesics; Animals; Caffeine; Child; Female; Humans; Hydroge | 2015 |
Tramadol and Tramadol+Caffeine Synergism in the Rat Formalin Test Are Mediated by Central Opioid and Serotonergic Mechanisms.
Topics: Analgesics, Opioid; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin; | 2015 |
Antinociceptive Effect of Racemic Flurbiprofen and Caffeine Co-Administration in an Arthritic Gout-Type Pain in Rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Caffeine; Disease Models, Animal | 2016 |
Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Chemical and Drug Induced Liver In | 2017 |
Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System | 2008 |
The antinociceptive interaction of anandamide and adenosine at the spinal level.
Topics: Adenosine; Analgesics; Animals; Arachidonic Acids; Caffeine; Dose-Response Relationship, Drug; Drug | 2009 |
Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Behavior, Animal; Benzene Derivatives; Caffeine; Diseas | 2009 |
Ryanodine receptors contribute to the induction of nociceptive input-evoked long-term potentiation in the rat spinal cord slice.
Topics: Afferent Pathways; Animals; Caffeine; Cells, Cultured; Electric Stimulation; Excitatory Postsynaptic | 2010 |
Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice.
Topics: Adenosine A1 Receptor Antagonists; Analgesics; Animals; Caffeine; Carbamazepine; Drug Antagonism; Fe | 2010 |
Acupuncture for mice.
Topics: Acupuncture Therapy; Adenosine; Animals; Caffeine; Humans; Mice; Models, Animal; Pain; Pain Manageme | 2010 |
Caffeine lowers muscle pain during exercise in hot but not cool environments.
Topics: Adult; Bicycling; Caffeine; Cold Temperature; Exercise; Hot Temperature; Humans; Male; Muscle, Skele | 2011 |
A hangover remedy for the holidays?
Topics: Alcohol Drinking; Aspirin; Caffeine; Headache; Humans; Pain; Pain Management | 2011 |
Suspected opioid overdose case resolved by CYP2D6 genotyping.
Topics: Acetaminophen; Adolescent; Analgesics, Opioid; Caffeine; Codeine; Cytochrome P-450 CYP2D6; Drug Comb | 2012 |
Evaluation of anti-nociceptive, anti-inflammatory and antipyretic activities of Artemisia scoparia hydromethanolic extract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Artemisia; Caffeine; Carrageenan; Edema | 2013 |
Regular intake of non-opioid analgesics is associated with an increased risk of restless legs syndrome in patients maintained on antidepressants.
Topics: Adrenergic beta-Antagonists; Adult; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Anti | 2002 |
Use of fiorinal for postpartum pain and discomfort.
Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Female; Humans; Pain; Postpartum Per | 1957 |
Use of fiorinal for postpartum pain and discomfort.
Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Female; Humans; Pain; Postpartum Per | 1957 |
Use of fiorinal for postpartum pain and discomfort.
Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Female; Humans; Pain; Postpartum Per | 1957 |
Use of fiorinal for postpartum pain and discomfort.
Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Female; Humans; Pain; Postpartum Per | 1957 |
Neurological agents in child psychiatry.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Caffeine; Child; Child Psychiatry; Humans; Morphine | 1957 |
[On a new kind of analgesia with a new caffeine derivative].
Topics: Analgesia; Caffeine; Headache; Pain; Pain Management; Rheumatic Diseases | 1959 |
Analgesia for postpartum pain.
Topics: Analgesia; Analgesics; Aspirin; Caffeine; Codeine; Dextropropoxyphene; Female; Humans; Pain; Pain Ma | 1963 |
DOUBLE-BLIND EVALUATION OF TWO ANALGESIC COMBINATIONS FOR PAIN AFTER MINOR ORAL SURGICAL PROCEDURES.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Caffeine; Dextropropoxyphene; Double-Bl | 1963 |
[GYNECOLOGIC PAIN SYNDROMES AND THEIR TREATMENT].
Topics: Caffeine; Gynecology; Humans; Pain; Pelvis; Procaine; Somatoform Disorders; Syndrome | 1964 |
[LIPOLYMPHANGIA].
Topics: Adipose Tissue; Caffeine; Geriatrics; Humans; Knee; Pain; Procaine | 1963 |
TREATMENT OF POSTPARTUM PAIN WITH FIORINAL.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Barbiturates; Biomedical Research; Caff | 1964 |
[THE EFFECT OF SOME ANALGESICS ON DERMAL PAIN CAUSED BY HEAT IRRADIATION].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Caffeine; Hot Temperature; Pain; Pharmacology; P | 1964 |
THE LATENCY OF PRICKING-PAIN SENSATION. I. THE EFFECT OF ACETOPHENETIDIN AND ANACIN. II. THE EFFECT OF REPEATED STIMULATION.
Topics: Aspirin; Biomedical Research; Body Temperature; Caffeine; Hot Temperature; Humans; Pain; Pharmacolog | 1965 |
[EVALUATION OF THE SIEGMUND TEST OF THE ANALGESIC POWER OF SEVERAL DRUGS].
Topics: Aminopyrine; Analgesics; Caffeine; Chlormezanone; Mice; Pain; Pharmacology; Phenylbutazone; Research | 1963 |
[Toxic psychoses due to sedormid, saridon and contra-pain].
Topics: Analgesics; Antipyrine; Caffeine; Drug Combinations; Humans; Hypnotics and Sedatives; Pain; Phenacet | 1950 |
Glomerular tip lesion associated with nonsteroidal anti-inflammatory drug-induced nephrotic syndrome.
Topics: Accidents, Traffic; Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Barbi | 2005 |
Morphine reward in dopamine-deficient mice.
Topics: Analgesics, Opioid; Animals; Brain; Caffeine; Dihydroxyphenylalanine; Dopamine; Dose-Response Relati | 2005 |
Modulation of paracetamol antinociception by caffeine and by selective adenosine A2 receptor antagonists in mice.
Topics: Acetaminophen; Adenosine A2 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Caffeine; Centr | 2006 |
Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine.
Topics: Acetaminophen; Animals; Aspirin; Brain; Caffeine; Corpus Striatum; Dopamine; Male; Norepinephrine; P | 2006 |
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
Topics: Analgesics; Animals; Caffeine; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response | 2006 |
Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury.
Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, | 2006 |
Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug.
Topics: Analgesics; Animals; Body Temperature; Brain; Caffeine; Central Nervous System Stimulants; Disease M | 2006 |
Caffeine-related genital skin pain.
Topics: Adolescent; Aged; Caffeine; Central Nervous System Stimulants; Coffee; Female; Genital Diseases, Fem | 2008 |
Prospective study of "fibrocystic breast disease" and caffeine consumption.
Topics: Adult; Aged; Breast; Caffeine; Coffee; Diet; Female; Fibrocystic Breast Disease; Humans; Menopause; | 1984 |
[Gynecologic-obstetric pain therapy. Use of Lonarid N].
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Caffeine; Codeine; Drug Combinations; Dysmenorrhea; E | 1980 |
Problems with the use of oxycodone compound in patients with chronic pain.
Topics: Aspirin; Caffeine; Chronic Disease; Codeine; Dextropropoxyphene; Drug Combinations; Female; Humans; | 1981 |
Aconitine-induced writhing as a method for assessing aspirin-like analgesic activity.
Topics: Aconitine; Aconitum; Analgesics; Animals; Aspirin; Behavior, Animal; Caffeine; Drug Evaluation, Prec | 1980 |
Relative potency of two preparations in two-way elimination of heterogeneity designs with multivariate responses.
Topics: Acetaminophen; Analgesia; Analgesics; Biometry; Caffeine; Dentistry; Humans; Mathematics; Models, St | 1995 |
Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Dioxanes; Drug Synergism; Formaldehyde; Hot Tempera | 1995 |
Calcium modulation of morphine analgesia: role of calcium channels and intracellular pool calcium.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Cell Compartmentation; Male; Membrane Potentials; Mice | 1995 |
A device for automatic measurement of writhing and its application to the assessment of analgesic agents.
Topics: Acetates; Acetic Acid; Aminopyrine; Analgesics; Animals; Behavior, Animal; Caffeine; Disease Models, | 1994 |
Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat.
Topics: Animals; Aspirin; Caffeine; Drug Synergism; Female; Gentisates; Hindlimb; Hydroxybenzoates; Pain; Ra | 1994 |
Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat.
Topics: Acetaminophen; Administration, Oral; Animals; Caffeine; Drug Combinations; Drug Synergism; Female; H | 1993 |
[A fixed combination of acetylsalicylic acid and paracetamol is absolutely effective. Interview by Dr. rer. nat. Anita Schweiger].
Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Humans; Pain; Pain Measurement; Phen | 1996 |
Silicone breast implants and drug-induced arthralgia.
Topics: Arthralgia; Breast Implants; Caffeine; Cyclizine; Diagnosis, Differential; Drug Combinations; Ergota | 1997 |
Adenosine receptors. Knockouts anxious for new therapy.
Topics: Adenosine; Animals; Caffeine; Drug Therapy; Mice; Mice, Knockout; Pain; Receptors, Purinergic P1 | 1997 |
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.
Topics: Adenosine; Aggression; Animals; Blood Pressure; Brain; Caffeine; Cloning, Molecular; Heart Rate; Hum | 1997 |
Caffeine induces central cholinergic analgesia.
Topics: Analgesia; Animals; Caffeine; Central Nervous System Stimulants; Cholinergic Agents; Dose-Response R | 1997 |
[The use of the preparation Solpadeine in dental practice].
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caff | 1997 |
Stress-dependent antinociceptive effects of carbamazepine: a study in stressed and nonstressed rats.
Topics: Adenosine; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Caffeine; Carbamazepine; Cerebra | 1998 |
Oscillatory effects of repeated morphine on shock-induced hypoalgesia and beta-endorphin.
Topics: Analysis of Variance; Animals; beta-Endorphin; Caffeine; Electroshock; Lithium Chloride; Male; Morph | 1998 |
Inhibition of strychnine-allodynia is mediated by spinal adenosine A1- but not A2-receptors in the rat.
Topics: Adenosine; Animals; Blood Pressure; Caffeine; Heart Rate; Injections, Spinal; Male; Pain; Phenethyla | 1998 |
On the analgesic effect of sodium diclofenac in pain-induced functional impairment in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Diclofenac; Dose-Response Re | 1998 |
Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine.
Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Dose-Resp | 1999 |
Effect of coadministration of caffeine and either adenosine agonists or cyclic nucleotides on ketorolac analgesia.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Administration, Topical; Analgesics, Non-Narcotic; Animals; | 1999 |
Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Caffeine; Desipramine; Drug Evaluation, Precli | 1999 |
Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Analgesics; Animals; Anti-Inf | 1999 |
Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System | 2000 |
"No, Duke. No divorce".
Topics: Aspirin; Caffeine; Deception; Drug Combinations; Drug Prescriptions; Humans; Male; Middle Aged; Oxyc | 2001 |
Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Caffeine; Disease Models | 2001 |
Quantitative design of optimal analgesic combination of acetaminophen, caffeine, and butalbital.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Barbiturates; Caffeine; Carrageenan; Dose-Response | 2001 |
[Neurophysiologic analysis of the effect of phenamine and caffeine or cortical neurons].
Topics: Amphetamine; Animals; Auditory Perception; Caffeine; Cats; Caudate Nucleus; Cerebral Cortex; Electri | 1976 |
Letter: The clinical course of patients with analgesic nephropathy.
Topics: Analgesics; Aspirin; Caffeine; Codeine; Creatinine; Female; Follow-Up Studies; Humans; Kidney; Kidne | 1975 |
Pharmacokinetic/pharmacodynamic analysis of the interaction between acetaminophen and caffeine.
Topics: Acetaminophen; Administration, Oral; Animals; Caffeine; Chromatography, High Pressure Liquid; Drug S | 1992 |
Pain and discomfort associated with film-screen mammography.
Topics: Anxiety; Breast; Caffeine; Female; Humans; Mammography; Menopause; Menstrual Cycle; Middle Aged; Pai | 1991 |
[Chronic use of analgesics].
Topics: Adult; Analgesics; Caffeine; Case-Control Studies; Drug Combinations; Drug Prescriptions; Female; Hu | 1990 |
Assessment of the role of A1/A2 adenosine receptors mediating the purine antinociception, motor and autonomic function in the rat spinal cord.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Autonomic Nervous System; Blood Pressure; Caf | 1989 |
Caffeine restriction as initial treatment for breast pain.
Topics: Adolescent; Adult; Aged; Caffeine; Coffee; Female; Fibrocystic Breast Disease; Humans; Middle Aged; | 1989 |
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.
Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricula | 1986 |
Patient discomfort during screen-film mammography.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Caffeine; Female; Humans; Mammography; Menstruatio | 1988 |
[A new analgesic in pediatric practice: Sig 8304].
Topics: Adolescent; Analgesics; Antipyrine; Benzoates; Caffeine; Child; Child, Preschool; Drug Combinations; | 1986 |
Morphine--caffeine analgesic interaction in rats.
Topics: Analgesics; Animals; Caffeine; Drug Synergism; Electric Stimulation; Hot Temperature; Male; Morphine | 1985 |
Calcific tendonitis of the longus colli muscle: a cause of atraumatic neck pain.
Topics: Adult; Aspirin; Barbiturates; Caffeine; Calcinosis; Drug Combinations; Female; Humans; Male; Oxycodo | 1985 |
[Evaluation of the analgesic activity of a preconstituted combination of acetylsalicylic acid, paracetamol and caffeine].
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Drug Combinations; Drug Evaluation; Female; Hum | 1985 |
[Letter: Huneke's neural therapy?].
Topics: Caffeine; Complementary Therapies; Germany, West; Humans; Pain; Procaine | 1973 |
A comparison of propoxyphene HCl (Darvon) and an analgesic mixture (Percogesic) in pain relief after gingivectomy.
Topics: Acetaminophen; Adult; Analgesics; Atropine; Caffeine; Dextropropoxyphene; Female; Gingivectomy; Hist | 1967 |
[Clinical study of a new antalgic: Propofan].
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Caffeine; Dextropropoxyphene; Female; Headache; His | 1972 |
[A study of sensation by the double simultaneous stimulation method].
Topics: Adult; Amphetamine; Brain Diseases; Caffeine; Epinephrine; Female; Humans; Hypesthesia; Methods; Pai | 1974 |
[Octadon N].
Topics: Analgesics; Aspirin; Caffeine; Drug Combinations; Germany, West; Headache; Humans; Migraine Disorder | 1974 |
[Intensification of effect using a combination of analgesic drugs in a split-tablet].
Topics: Analgesics; Antipyrine; Caffeine; Drug Combinations; Humans; Mandelic Acids; Pain; Salicylamides; Sa | 1974 |
[Clinical experiences with Fortalidon in painful conditions in gynecology and obstetrics].
Topics: Aminopyrine; Analgesics; Aspirin; Barbiturates; Caffeine; Codeine; Drug Combinations; Female; Genita | 1972 |
[Comparative studies on the analgesic effect of diphenyl-methoxy-benzylaminopropane-hydrochloride (ST 4250)].
Topics: Analgesics; Benzhydryl Compounds; Benzyl Compounds; Caffeine; Humans; Methyl Ethers; Pain; Phenaceti | 1973 |
The effects of caffeine and theophylline on nociceptive stimulation in the rat.
Topics: Animals; Caffeine; Central Nervous System; Dose-Response Relationship, Drug; Electric Stimulation; I | 1973 |
Effects of caffeine on the absorption and analgesic efficacy of paracetamol in rats.
Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Caffeine; Depression, Chemical; Dose-Respo | 1973 |
[On the treatment of inflammatory and degenerative diseases of the musculosketetal system with Vertebran].
Topics: Atropine; Bone Diseases; Caffeine; Ergoloid Mesylates; Humans; Joint Diseases; Muscular Diseases; Pa | 1968 |
[Practical experience with Neuramag sine].
Topics: Acetaminophen; Adult; Aged; Aspirin; Caffeine; Chemical Phenomena; Chemistry; Drug Combinations; Fem | 1972 |
[The pain syndrome of the edentulous alveolar crest and its treatment].
Topics: Administration, Topical; Alveolar Process; Aminopyrine; Anti-Inflammatory Agents; Aspirin; Caffeine; | 1969 |
[Study of a new combination of analgesic substances].
Topics: Acetaminophen; Adult; Caffeine; Female; Humans; Male; Pain; Salicylamides | 1965 |
4-Dimethyl-amino methyl-2-methyl 1,3 dioxolane--a new potent analgesic agent.
Topics: Analgesics; Animals; Aspirin; Caffeine; Codeine; Dextropropoxyphene; Dioxoles; Electric Stimulation; | 1969 |
[Pain from the viewpoint of the general practitioner. Experiences with a new analgesic].
Topics: Adolescent; Adult; Aged; Amobarbital; Analgesics; Antipyrine; Caffeine; Family Practice; Humans; Mid | 1969 |
[Comparative examination of analgesics by means of threshold value in thermal skin irritation as criterion of the analgetic effect].
Topics: Analgesics; Burns; Caffeine; Humans; Pain; Phenacetin; Phenethylamines; Time Factors | 1969 |
[Ambulatory experiences with a new analgesic].
Topics: Adult; Aged; Ambulatory Care; Aminopyrine; Amobarbital; Analgesics; Antipyrine; Caffeine; Female; Hu | 1969 |
[A comparative study of the neuronal reactions of the paleo- and neo-cortex of the guinea pig brain].
Topics: Animals; Caffeine; Cerebral Cortex; Chlorpromazine; Electrophysiology; Guinea Pigs; Hearing; Hippoca | 1970 |
Individual differences in pain threshold and level of arousal.
Topics: Arousal; Body Temperature; Caffeine; Extraversion, Psychological; Female; Humans; Introversion, Psyc | 1967 |
Primary erythermalgia. Report of a patient treated with methysergide maleate.
Topics: Aspirin; Caffeine; Codeine; Edema; Erythromelalgia; Female; Humans; Maleates; Methysergide; Middle A | 1968 |
[The influence of caffeine on the analgesic effects of salicylamide].
Topics: Animals; Caffeine; Drug Synergism; Pain; Rabbits; Salicylamides | 1965 |
[Apropos of pain in herpes zoster. Treatment with a new drug complex with a base of D-propoxyphene].
Topics: Adult; Aged; Aspirin; Caffeine; Dextropropoxyphene; Herpes Zoster; Humans; Male; Middle Aged; Pain; | 1966 |