Page last updated: 2024-10-24

caffeine and Ache

caffeine has been researched along with Ache in 176 studies

Research Excerpts

ExcerptRelevanceReference
"This study evaluated the analgesic effects of low-level laser therapy (LLLT) and paracetamol-caffeine in controlling orthodontic pain induced by elastomeric separators, as well as changes in oral health-related quality of life (OHRQoL)."9.51The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial. ( Al-Sabbagh, R; Hajeer, MY; Murad, RMT; Owayda, AM, 2022)
"Caffeine infusion significantly reduced pain and drowsiness, but the reduction did not reach clinical significance in patients with advanced cancer undergoing opioid therapy."9.17Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial. ( Ahn, HY; Bae, WK; Cho, K; Choi, YS; Kim, YS; Lee, JH; Oh, SC; Seo, AR; Suh, SY, 2013)
"Caffeine does not have an analgesic effect on ischemic pain, either by a peripheral or by a central site of action."9.14Caffeine does not attenuate experimentally induced ischemic pain in healthy subjects. ( Dellermalm, J; Grass, S; Segerdahl, M, 2009)
"Caffeine increased the pain-free walking distance by 20."9.14Randomized double-blind placebo-controlled crossover study of caffeine in patients with intermittent claudication. ( Jensen, MB; Lindholt, JS; Madsen, MR; Momsen, AH; Norager, CB; Vestersgaard-Andersen, T, 2010)
"This experiment examined the effect of a moderate dose of caffeine on quadriceps muscle pain during a bout of high-intensity cycling in low- versus high-caffeine-consuming males."9.14Effect of caffeine on quadriceps muscle pain during acute cycling exercise in low versus high caffeine consumers. ( Arngrimsson, SA; Broglio, SP; Gliottoni, RC; Meyers, JR; Motl, RW, 2009)
"This experiment examined the effect of a moderate dose of caffeine on perceptions of leg-muscle pain during a bout of high-intensity cycling exercise and the role of anxiety sensitivity in the hypoalgesic effect of caffeine on muscle pain during exercise."9.13Effect of caffeine on leg-muscle pain during intense cycling exercise: possible role of anxiety sensitivity. ( Gliottoni, RC; Motl, RW, 2008)
" This experiment found that caffeine (equal to approximately 2 cups of brewed coffee) could produce a large reduction in pain resulting from eccentric exercise-induced, delayed-onset muscle injury."9.12Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise. ( Dudley, GA; Maridakis, V; McCully, KK; O'Connor, PJ, 2007)
"This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain and blood pressure during moderate intensity cycling exercise."9.11Dose-dependent effect of caffeine on reducing leg muscle pain during cycling exercise is unrelated to systolic blood pressure. ( Broglio, SP; Ely, MR; Motl, RW; O'Connor, PJ, 2004)
"In a double-blind, randomized controlled trial among 500 post-partum patients experiencing moderate to severe pain, a single oral dose of an aspirin/caffeine combination (800 mg aspirin, 65 mg caffeine) provided significantly more pain relief at 2 hours than did a higher dose of an acetaminophen/aspirin combination (648 mg acetaminophen, 648 mg aspirin) and a higher dose of acetaminophen alone (1000 mg acetaminophen)."9.05A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain. ( Rubin, A; Winter, L, 1984)
"Thirty-two papers, with 49 different experimental studies were identified (12 pain, 21 nicotine, 7 caffeine, 9 alcohol)."8.85Identifying experimental methods to determine the effect of pain on attention: a review of pain, caffeine, alcohol and nicotine studies. ( Eccleston, C; Keogh, E; Moore, DJ, 2009)
"Results of this study completed with community-dwelling adults revealed that individuals who habitually consume greater amounts of caffeine as part of their daily diets demonstrate diminished sensitivity to painful stimuli in a laboratory setting."7.88Higher habitual dietary caffeine consumption is related to lower experimental pain sensitivity in a community-based sample. ( Aroke, EN; Cable, ST; Goodin, BR; Overstreet, DS; Penn, TM, 2018)
"Many human and animal studies have shown the influence of nicotine and caffeine on pain perception and processing."7.80Influences of smoking and caffeine consumption on trigeminal pain processing. ( Diener, HC; Heber, A; Holle, D; Katsarava, Z; Naegel, S; Obermann, M, 2014)
"Caffeine (CAF) ingestion may enhance endurance exercise by lowering perceived exertion (RPE) and muscle pain."7.77Caffeine lowers muscle pain during exercise in hot but not cool environments. ( Anderson, JM; Armstrong, LE; Casa, DJ; Emmanuel, H; Ganio, MS; Johnson, EC; Lopez, RM; Maresh, CM; Stearns, RL; Volek, JS, 2011)
"This study compared effects of the mu opioid receptor agonist morphine (an acknowledged analgesic), the dopamine receptor antagonist haloperidol (a non-analgesic sedative), the adenosine receptor antagonist caffeine (a non-analgesic stimulant) and the neurokinin-1 receptor antagonist CJ 11,974-01 (a candidate analgesic) on acetic acid-induced writhing (a traditional pain-stimulated behavior) and acetic acid-induced suppression of locomotor activity (a pain-depressed behavior) in male ICR mice."7.75Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice. ( Adams, C; Bilsky, EJ; Cormier, J; Dunbar, C; Mercer, H; Negus, SS; Stevenson, GW, 2009)
"Caffeine, used in many pain medications as an adjuvant analgesic, is an adenosine A1 and A2A receptor antagonist."7.73Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury. ( Fredholm, BB; Hao, JX; Wiesenfeld-Hallin, Z; Wu, WP; Xu, XJ, 2006)
"This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions."7.71Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001)
"Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)."7.70Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999)
"In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain."7.70Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000)
"The ability of caffeine to potentiate the analgesic effect of aspirin was studied in the pain-induced functional impairment model in the rat."7.69Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Castillo-Méndez, MS; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ, 1994)
"The analgesic activities of paracetamol (100, 178, 316 and 562 mg kg-1), caffeine (10, 18, 32 and 56 mg kg-1) and combinations of these doses were tested on a pain-induced functional impairment model in the rat."7.68Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ; Salazar, LA; Villarreal, JE, 1993)
"" The hypothesis suggesting that abstention from coffee and caffeine consumption eliminates breast pain and resolves breast nodules was based on an uncontrolled clinical study."7.67Prospective study of "fibrocystic breast disease" and caffeine consumption. ( Heyden, S; Muhlbaier, LH, 1984)
"The effects of methylxanthines (caffeine, theophylline and theobromine) on the symptoms associated with fibrocystic breast disease were studied in 147 patients."7.67Caffeine restriction as initial treatment for breast pain. ( Russell, LC, 1989)
"In a pain management program (200 patients), a group of daily users of oxycodone compound (29 patients) and a subgroup who were taking a "high dose" of oxycodone compound (13 patients) were compared with a group of 171 non-users of oxycodone compound."7.66Problems with the use of oxycodone compound in patients with chronic pain. ( Maruta, T; Swanson, DW, 1981)
"Thalidomide was introduced as a sedative and antiemetic agent to the European market in the late 1950s."6.42[Novel potential uses of thalidomide in the management of pain? A review of the literature]. ( Bruera, E; Peuckmann, V; Strumpf, M; Zenz, M, 2003)
"These data do not support the hypothesis that occasional intake of a small dose of caffeine as part of pain medication imposes a health risk due to vital sign changes."5.69Lack of Evidence for Blood Pressure Effects of Caffeine Added to Ibuprofen. ( Lampert, A; Lange, R; Weiser, T, 2023)
"This study evaluated the analgesic effects of low-level laser therapy (LLLT) and paracetamol-caffeine in controlling orthodontic pain induced by elastomeric separators, as well as changes in oral health-related quality of life (OHRQoL)."5.51The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial. ( Al-Sabbagh, R; Hajeer, MY; Murad, RMT; Owayda, AM, 2022)
"Caffeine is able to increase the effect of rac-Flur in the arthritic gout-type pain in rats."5.43Antinociceptive Effect of Racemic Flurbiprofen and Caffeine Co-Administration in an Arthritic Gout-Type Pain in Rats. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; Liévano-Reyes, R; López-Muñoz, FJ; Pérez-Méndez, HI; Solís-Oba, A, 2016)
"Genital hyperesthesia is more recognized in women but may affect men."5.35Caffeine-related genital skin pain. ( Markos, AR, 2008)
"This review was designated to evaluate the efficacy of parenteral ketorolac in treating acute migraine headache."5.22Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis. ( Abu Bakar, MA; Baharuddin, KA; Norhayati, MN; Nurathirah, MN; Yazid, MB, 2022)
"Caffeine infusion significantly reduced pain and drowsiness, but the reduction did not reach clinical significance in patients with advanced cancer undergoing opioid therapy."5.17Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial. ( Ahn, HY; Bae, WK; Cho, K; Choi, YS; Kim, YS; Lee, JH; Oh, SC; Seo, AR; Suh, SY, 2013)
"Painful laser stimuli were delivered to 20 healthy subjects before and after administration of a drink with 0 or 4 mg/kg caffeine."5.15Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo. ( Bjørkedal, E; Flaten, MA, 2011)
"Caffeine does not have an analgesic effect on ischemic pain, either by a peripheral or by a central site of action."5.14Caffeine does not attenuate experimentally induced ischemic pain in healthy subjects. ( Dellermalm, J; Grass, S; Segerdahl, M, 2009)
"Caffeine increased the pain-free walking distance by 20."5.14Randomized double-blind placebo-controlled crossover study of caffeine in patients with intermittent claudication. ( Jensen, MB; Lindholt, JS; Madsen, MR; Momsen, AH; Norager, CB; Vestersgaard-Andersen, T, 2010)
"This experiment examined the effect of a moderate dose of caffeine on quadriceps muscle pain during a bout of high-intensity cycling in low- versus high-caffeine-consuming males."5.14Effect of caffeine on quadriceps muscle pain during acute cycling exercise in low versus high caffeine consumers. ( Arngrimsson, SA; Broglio, SP; Gliottoni, RC; Meyers, JR; Motl, RW, 2009)
"This experiment examined the effect of a moderate dose of caffeine on perceptions of leg-muscle pain during a bout of high-intensity cycling exercise and the role of anxiety sensitivity in the hypoalgesic effect of caffeine on muscle pain during exercise."5.13Effect of caffeine on leg-muscle pain during intense cycling exercise: possible role of anxiety sensitivity. ( Gliottoni, RC; Motl, RW, 2008)
" This experiment found that caffeine (equal to approximately 2 cups of brewed coffee) could produce a large reduction in pain resulting from eccentric exercise-induced, delayed-onset muscle injury."5.12Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise. ( Dudley, GA; Maridakis, V; McCully, KK; O'Connor, PJ, 2007)
"The aim of this study was to determine the analgesic effect of acetaminophen compared to a combination of both caffeine and acetaminophen or caffeine alone using tonic and phasic pain stimulation."5.12Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen. ( Beisel, A; Brune, K; Clarke, G; Grattan, T; Kobal, G; Mueller, C; Renner, B; Werner, U, 2007)
"This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain and blood pressure during moderate intensity cycling exercise."5.11Dose-dependent effect of caffeine on reducing leg muscle pain during cycling exercise is unrelated to systolic blood pressure. ( Broglio, SP; Ely, MR; Motl, RW; O'Connor, PJ, 2004)
"A single-blind, randomized clinical trial of 56 female subjects was conducted to determine whether decreased consumption of caffeine decreases breast pain/tenderness or nodularity in patients with suspected benign proliferative breast disease."5.06The effect of decreased caffeine consumption on benign proliferative breast disease: a randomized clinical trial. ( Allen, SS; Froberg, DG, 1987)
"In a double-blind, randomized controlled trial among 500 post-partum patients experiencing moderate to severe pain, a single oral dose of an aspirin/caffeine combination (800 mg aspirin, 65 mg caffeine) provided significantly more pain relief at 2 hours than did a higher dose of an acetaminophen/aspirin combination (648 mg acetaminophen, 648 mg aspirin) and a higher dose of acetaminophen alone (1000 mg acetaminophen)."5.05A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain. ( Rubin, A; Winter, L, 1984)
"Paracetamol/caffeine (1,000 mg/130 mg) is effective and safe for use in acute management of pain."4.86A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine. ( Day, R; Graham, G; Palmer, H; Williams, K, 2010)
"Thirty-two papers, with 49 different experimental studies were identified (12 pain, 21 nicotine, 7 caffeine, 9 alcohol)."4.85Identifying experimental methods to determine the effect of pain on attention: a review of pain, caffeine, alcohol and nicotine studies. ( Eccleston, C; Keogh, E; Moore, DJ, 2009)
"Potentially remediable risk factors include frequency of migraine attacks, obesity, excessive use of medications containing opioids and barbiturates, caffeine overuse, stressful life events, depression, sleep disorders and cutaneous allodynia."4.85What predicts the change from episodic to chronic migraine? ( Bigal, ME; Lipton, RB, 2009)
" Some investigations did find associations between breast pain and premenstrual syndrome, fibrocystic breast disease, and caffeine intake."4.81Benign breast pain in women: a practical approach to evaluation and treatment. ( Norlock, FE, 2002)
"A prediction model development study was completed using the 2006 American Migraine Prevalence and Prevention Study survey, from participants who were aged ≥18, met criteria and headache day frequency for episodic migraine, did not take prescription medication for migraine, and used ≥1 of the following acute migraine medication classes: acetaminophen, aspirin, NSAIDs, or caffeine containing combination products (CCP)."4.12Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study. ( Armand, CE; Buse, DC; Ezzati, A; Fanning, KM; Lipton, RB; Martin, VT; Pavlovic, JM; Reed, ML, 2022)
"The purine alkaloid caffeine is the most widely consumed psychostimulant drug in the world and has multiple beneficial pharmacological activities, for example, in neurodegenerative diseases."4.02The Medicinal Chemistry of Caffeine. ( Arifi, S; Faudone, G; Merk, D, 2021)
"Results of this study completed with community-dwelling adults revealed that individuals who habitually consume greater amounts of caffeine as part of their daily diets demonstrate diminished sensitivity to painful stimuli in a laboratory setting."3.88Higher habitual dietary caffeine consumption is related to lower experimental pain sensitivity in a community-based sample. ( Aroke, EN; Cable, ST; Goodin, BR; Overstreet, DS; Penn, TM, 2018)
"Acetaminophen (APAP) is a widely used analgesic drug that is frequently co-administered with caffeine (CAF) in the treatment of pain."3.85Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans. ( Baier, V; Blank, LM; Cordes, H; Kuepfer, L; Thiel, C, 2017)
"Many human and animal studies have shown the influence of nicotine and caffeine on pain perception and processing."3.80Influences of smoking and caffeine consumption on trigeminal pain processing. ( Diener, HC; Heber, A; Holle, D; Katsarava, Z; Naegel, S; Obermann, M, 2014)
"Caffeine (CAF) ingestion may enhance endurance exercise by lowering perceived exertion (RPE) and muscle pain."3.77Caffeine lowers muscle pain during exercise in hot but not cool environments. ( Anderson, JM; Armstrong, LE; Casa, DJ; Emmanuel, H; Ganio, MS; Johnson, EC; Lopez, RM; Maresh, CM; Stearns, RL; Volek, JS, 2011)
"Oxcarbazepine is an anticonvulsant drug that has been explored as a novel therapeutic agent to treat neuropathic pain in humans."3.76Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice. ( Fredholm, BB; Reid, AR; Sawynok, J, 2010)
"This study compared effects of the mu opioid receptor agonist morphine (an acknowledged analgesic), the dopamine receptor antagonist haloperidol (a non-analgesic sedative), the adenosine receptor antagonist caffeine (a non-analgesic stimulant) and the neurokinin-1 receptor antagonist CJ 11,974-01 (a candidate analgesic) on acetic acid-induced writhing (a traditional pain-stimulated behavior) and acetic acid-induced suppression of locomotor activity (a pain-depressed behavior) in male ICR mice."3.75Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice. ( Adams, C; Bilsky, EJ; Cormier, J; Dunbar, C; Mercer, H; Negus, SS; Stevenson, GW, 2009)
"Both anandamide and adenosine have significant roles in pain mechanisms, but no data are available concerning their interaction at the spinal level."3.75The antinociceptive interaction of anandamide and adenosine at the spinal level. ( Benedek, G; Horvath, G; Kekesi, G; Nagy, E; Tuboly, G, 2009)
"Amitriptyline is used to treat neuropathic pain in humans."3.74Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors. ( Fredholm, BB; Reid, AR; Sawynok, J, 2008)
"Caffeine, used in many pain medications as an adjuvant analgesic, is an adenosine A1 and A2A receptor antagonist."3.73Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury. ( Fredholm, BB; Hao, JX; Wiesenfeld-Hallin, Z; Wu, WP; Xu, XJ, 2006)
"The fixed combination of aspirin, paracetamol (acetaminophen) and caffeine has been used successfully to treat different kinds of pain including migraine attacks."3.73Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine. ( Aicher, B; Akundi, RS; Candelario-Jalil, E; Fiebich, BL; Finkenzeller, G; Heinzmann, M; Hüll, M; Knörle, R; Mantovani, M; Schnierle, P, 2006)
"This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions."3.71Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001)
"Caffeine potentiation of ketorolac-induced antinociception in the pain-induced functional impairment model in rats was assessed."3.70Effect of coadministration of caffeine and either adenosine agonists or cyclic nucleotides on ketorolac analgesia. ( Aguirre-Bañuelos, P; Castañeda-Hernández, G; Granados-Soto, V; López-Muñoz, FJ, 1999)
"Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)."3.70Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999)
"Spinal administration of an adenosine kinase inhibitor, alone or in combination with an adenosine deaminase inhibitor, produces antinociception in inflammatory pain tests."3.70Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor. ( Poon, A; Sawynok, J, 1999)
"In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain."3.70Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000)
"The ability of caffeine to potentiate the analgesic effect of aspirin was studied in the pain-induced functional impairment model in the rat."3.69Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Castillo-Méndez, MS; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ, 1994)
"The analgesic activities of paracetamol (100, 178, 316 and 562 mg kg-1), caffeine (10, 18, 32 and 56 mg kg-1) and combinations of these doses were tested on a pain-induced functional impairment model in the rat."3.68Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ; Salazar, LA; Villarreal, JE, 1993)
"" The hypothesis suggesting that abstention from coffee and caffeine consumption eliminates breast pain and resolves breast nodules was based on an uncontrolled clinical study."3.67Prospective study of "fibrocystic breast disease" and caffeine consumption. ( Heyden, S; Muhlbaier, LH, 1984)
"The effects of methylxanthines (caffeine, theophylline and theobromine) on the symptoms associated with fibrocystic breast disease were studied in 147 patients."3.67Caffeine restriction as initial treatment for breast pain. ( Russell, LC, 1989)
"In a pain management program (200 patients), a group of daily users of oxycodone compound (29 patients) and a subgroup who were taking a "high dose" of oxycodone compound (13 patients) were compared with a group of 171 non-users of oxycodone compound."3.66Problems with the use of oxycodone compound in patients with chronic pain. ( Maruta, T; Swanson, DW, 1981)
"A painful writhing syndrome is produced by aconitine when given intraperitoneally."3.66Aconitine-induced writhing as a method for assessing aspirin-like analgesic activity. ( Bhalla, TN; Bhargava, KP, 1980)
"Caffeine has potential properties to counteract the central effects of morphine."2.70Effects of caffeine as an adjuvant to morphine in advanced cancer patients. A randomized, double-blind, placebo-controlled, crossover study. ( Casuccio, A; Mercadante, S; Serretta, R, 2001)
"The aim of the study was to investigate whether the analgesic effect of propyphenazone (PROP) was increased when it was administered in combination with caffeine (CAFF)."2.68Analgesic effects of propyphenazone in comparison to its combination with caffeine. ( Hummel, T; Kobal, G; Kraetsch, HG; Kussat, R; Lötsch, J, 1996)
"Caffeine is a very common CNS stimulant that has been of interest to physiologists because of its direct effects on skeletal muscle in vitro, as well as ergogenic effects on laboratory tests of human performance."2.43The influence of caffeine on voluntary muscle activation. ( Kalmar, JM, 2005)
"Thalidomide was introduced as a sedative and antiemetic agent to the European market in the late 1950s."2.42[Novel potential uses of thalidomide in the management of pain? A review of the literature]. ( Bruera, E; Peuckmann, V; Strumpf, M; Zenz, M, 2003)
" Long term use produces tolerance to some of the pharmacological effects."2.39Pharmacological rationale for the clinical use of caffeine. ( Sawynok, J, 1995)
"The consequences of chronic insufficient sleep for health remain uncertain."1.46Decreased alertness due to sleep loss increases pain sensitivity in mice. ( Alexandre, C; Ferreira, A; Latremoliere, A; Miracca, G; Scammell, TE; Woolf, CJ; Yamamoto, M, 2017)
"Caffeine is able to increase the effect of rac-Flur in the arthritic gout-type pain in rats."1.43Antinociceptive Effect of Racemic Flurbiprofen and Caffeine Co-Administration in an Arthritic Gout-Type Pain in Rats. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; Liévano-Reyes, R; López-Muñoz, FJ; Pérez-Méndez, HI; Solís-Oba, A, 2016)
" The potential efficacy of these MN for paediatric dosing was investigated via in vitro and in vivo studies."1.42Potential of hydrogel-forming and dissolving microneedles for use in paediatric populations. ( Caffarel-Salvador, E; Donnelly, RF; McCarthy, HO; McElnay, JC; Mooney, K; Tuan-Mahmood, TM; Woolfson, AD, 2015)
"Genital hyperesthesia is more recognized in women but may affect men."1.35Caffeine-related genital skin pain. ( Markos, AR, 2008)
" Dopamine-deficient mice have a rightward shift in the dose-response curve to morphine on the tail-flick test (a pain sensitivity assay), suggesting either a decreased sensitivity to the analgesic effects of morphine and/or basal hyperalgesia."1.33Morphine reward in dopamine-deficient mice. ( Hnasko, TS; Palmiter, RD; Sotak, BN, 2005)
"When caffeine was administered prior to MDMA, a potentiation of locomotor activity was observed, which consisted in an increase in maximal values and in a prolonged time of activity."1.33Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug. ( Camarasa, J; Escubedo, E; Pubill, D, 2006)
"According to the degree of importance to the combined analgesic effect, Ace > Caf > Bul; Ace showed a significant dose-response relationship, whereas in Caf and Bul, this relationship was not apparent."1.31Quantitative design of optimal analgesic combination of acetaminophen, caffeine, and butalbital. ( Gui, CQ; Sun, RY; Wang, XW; Zheng, QS, 2001)
"Caffeine was used as a partial control for the lithium."1.30Oscillatory effects of repeated morphine on shock-induced hypoalgesia and beta-endorphin. ( Antelman, SM; Austin, MC; Caggiula, AR; Edwards, DJ; Fowler, H; Gershon, S; Kucinski, BJ, 1998)
"Caffeine did not produce an anti-inflammatory effect as determined by hindpaw plethysmometry, suggesting that antinociception was not secondary to an anti-inflammatory action."1.29Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms. ( Doak, GJ; Reid, AR; Sawynok, J, 1995)
" In each series of experiments, dose-response curves for morphine (probit analysis) were determined with and without the addition of caffeine (30 mg X kg-1)."1.27Morphine--caffeine analgesic interaction in rats. ( Bradley, EL; Brown, PT; Kissin, I; Person, DL; Vinik, HR; Xavier, AV, 1985)
"Retropharyngeal calcific tendonitis is a not-infrequent cause of atraumatic neck pain."1.27Calcific tendonitis of the longus colli muscle: a cause of atraumatic neck pain. ( Widlus, DM, 1985)
"Phenacetin was removed from this preparation in 1970 and replaced by an approximately equal amount of ASA (ACC)."1.25Letter: The clinical course of patients with analgesic nephropathy. ( Gault, MH, 1975)

Research

Studies (176)

TimeframeStudies, this research(%)All Research%
pre-199081 (46.02)18.7374
1990's29 (16.48)18.2507
2000's35 (19.89)29.6817
2010's25 (14.20)24.3611
2020's6 (3.41)2.80

Authors

AuthorsStudies
Abo-Salem, OM1
Hayallah, AM1
Bilkei-Gorzo, A1
Filipek, B1
Zimmer, A1
Müller, CE1
Alfaraj, R1
Alabdulsalam, Z1
Alfaraj, Z1
Alsunni, H1
Alhawaj, H1
Omar, O1
Abuohashish, H1
Owayda, AM1
Hajeer, MY1
Murad, RMT1
Al-Sabbagh, R1
Nurathirah, MN1
Yazid, MB1
Norhayati, MN1
Baharuddin, KA1
Abu Bakar, MA1
Lampert, A1
Lange, R1
Weiser, T1
Ezzati, A1
Fanning, KM1
Buse, DC1
Pavlovic, JM1
Armand, CE1
Reed, ML1
Martin, VT1
Lipton, RB2
Faudone, G1
Arifi, S1
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Hnasko, TS1
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Hourani, SM1
Fiebich, BL1
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Heinzmann, M1
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Hüll, M1
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Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Transdermal Microneedle Patch To Enhance Topical Anaesthesia Before Intravenous Line Insertion for Blood Transfusion In Paediatric Thalassemia Patients[NCT05078463]Phase 220 participants (Actual)Interventional2021-09-15Completed
Effects of Caffeine in Patients With Intermittent Claudication.[NCT00388128]Phase 380 participants (Anticipated)Interventional2006-09-30Completed
Efficacy of Caffeine as an Adjuvant to Opioid Therapy in Cancer Pain: a Randomized, Double-blind, Placebo-controlled Trial[NCT00879775]Phase 241 participants (Actual)Interventional2009-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Degree of Fatigue at the Point of Time With Numeric Rating Scale From 0 to 10

Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a higher level of fatigue. (NCT00879775)
Timeframe: two days

Interventionscores (Mean)
Caffeine3.61
Placebo3.55

Health-related Quality of Life

Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a better health-related quality of life. (NCT00879775)
Timeframe: two days

Interventionscores (Mean)
Caffeine4.83
Placebo4.45

Numeric Rating of Scale (From 0 to 10) of Possible Sleep Disturbance of Opioids

Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a higher level of sleep disturbance. (NCT00879775)
Timeframe: two days

Interventionscores (Mean)
Caffeine3.53
Placebo3.80

Impact of Symptom Burden to Daily Life (by MD Anderson Symptom Inventory-Korean)

Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; a higher score represents a higher level of impact of symptom burden to daily life. (NCT00879775)
Timeframe: two days

,
Interventionscores (Mean)
Daily livingMoodWorkInterpersonal relationshipGait ability
Caffeine5.175.615.564.614.39
Placebo5.955.606.754.655.50

Numeric Rating of Scale (From 0 to 10) of Pain and Possible Side Effects (Drowsiness, Confusion, Nausea) of Opioids

Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; higher scores represent higher levels of pain, and possible side effects (drowsiness, confusion, nausea) of opioids. (NCT00879775)
Timeframe: two days

,
Interventionscores (Mean)
PainDrowsinessConfusionNausea
Caffeine2.222.831.892.28
Placebo3.103.052.201.80

Reviews

23 reviews available for caffeine and Ache

ArticleYear
Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2022, Volume: 29, Issue:9

    Topics: Caffeine; Dexamethasone; Diclofenac; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Pain; Ph

2022
Regulatory effect of caffeine on the acute and the chronic pain and its possible mechanisms.
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2014, Volume: 36, Issue:6

    Topics: Adenosine; Caffeine; Central Nervous System Stimulants; Chronic Pain; Humans; Pain

2014
What predicts the change from episodic to chronic migraine?
    Current opinion in neurology, 2009, Volume: 22, Issue:3

    Topics: Analgesics; Caffeine; Central Nervous System Stimulants; Chronic Disease; Clinical Trials as Topic;

2009
Caffeine and anaerobic performance: ergogenic value and mechanisms of action.
    Sports medicine (Auckland, N.Z.), 2009, Volume: 39, Issue:10

    Topics: Anaerobic Threshold; Bicycling; Blood Glucose; Caffeine; Catecholamines; Central Nervous System Stim

2009
Identifying experimental methods to determine the effect of pain on attention: a review of pain, caffeine, alcohol and nicotine studies.
    Human psychopharmacology, 2009, Volume: 24, Issue:8

    Topics: Adult; Attention; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; E

2009
A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine.
    Pain medicine (Malden, Mass.), 2010, Volume: 11, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Caffeine; Central Nervous System Stimulants; Datab

2010
Methylxanthines and pain.
    Handbook of experimental pharmacology, 2011, Issue:200

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Interact

2011
Caffeine and pain.
    Pain, 2011, Volume: 152, Issue:4

    Topics: Analgesics; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Humans; P

2011
Symptomatic uses of caffeine in patients with cancer.
    Journal of palliative care, 2003,Spring, Volume: 19, Issue:1

    Topics: Analgesics, Opioid; Caffeine; Humans; Neoplasms; Pain

2003
[Novel potential uses of thalidomide in the management of pain? A review of the literature].
    Schmerz (Berlin, Germany), 2003, Volume: 17, Issue:3

    Topics: Analgesics; Aspirin; Caffeine; Drug Therapy, Combination; Humans; Pain; Phenacetin; Thalidomide

2003
Antinociception and the new COX inhibitors: research approaches and clinical perspectives.
    CNS drug reviews, 2003,Fall, Volume: 9, Issue:3

    Topics: Adrenergic Agonists; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Cycloox

2003
The influence of caffeine on voluntary muscle activation.
    Medicine and science in sports and exercise, 2005, Volume: 37, Issue:12

    Topics: Caffeine; Central Nervous System; Evoked Potentials; Humans; Motor Activity; Muscle Contraction; Mus

2005
Caffeine analogs: biomedical impact.
    Cellular and molecular life sciences : CMLS, 2007, Volume: 64, Issue:16

    Topics: Alzheimer Disease; Asthma; Biomedical Research; Caffeine; Calcium; Central Nervous System Stimulants

2007
[How important are combined analgesic preparations?].
    Medizinische Monatsschrift fur Pharmazeuten, 1984, Volume: 7, Issue:12

    Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Drug Combinations; Humans; Kidney Dis

1984
Foods, and food and drug combinations, responsible for head and neck pain.
    Cephalalgia : an international journal of headache, 1982, Volume: 2, Issue:2

    Topics: Adult; Alcoholic Beverages; Amygdalin; Cacao; Caffeine; Child; Chronic Disease; Cluster Headache; Dr

1982
Pharmacological rationale for the clinical use of caffeine.
    Drugs, 1995, Volume: 49, Issue:1

    Topics: Animals; Apnea; Caffeine; Central Nervous System; Headache; Humans; Hypotension; Obesity; Pain; Phos

1995
Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action.
    Pharmacological reviews, 1993, Volume: 45, Issue:1

    Topics: Analgesics; Animals; Caffeine; Drug Synergism; Humans; Pain

1993
[Effectiveness of fixed analgesic combinations exemplified by thomapyrin].
    Wiener klinische Wochenschrift, 1996, Volume: 108, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Drug Combinations; Germany; Humans; Pain

1996
Benign breast pain in women: a practical approach to evaluation and treatment.
    Journal of the American Medical Women's Association (1972), 2002,Spring, Volume: 57, Issue:2

    Topics: Analgesics; Breast Diseases; Caffeine; Central Nervous System Stimulants; Female; Humans; Pain; Prem

2002
Inflammatory bowel disease and irritable bowel syndrome.
    The Medical clinics of North America, 1990, Volume: 74, Issue:1

    Topics: Caffeine; Cholecystectomy; Colon; Colonic Diseases, Functional; Diarrhea; Humans; Ileum; Incidence;

1990
Exogenous factors in panic disorder: clinical and research implications.
    The Journal of clinical psychiatry, 1988, Volume: 49, Issue:2

    Topics: Anxiety Disorders; Caffeine; Cocaine; Diet; Ethanol; Fear; Humans; Life Change Events; Marijuana Abu

1988
[Therapy of sleep disorders in old age].
    Medizinische Klinik, 1972, Dec-15, Volume: 67, Issue:50

    Topics: Age Factors; Butyrophenones; Caffeine; Cardiac Glycosides; Cerebrovascular Disorders; Chlormethiazol

1972
Propoxyphene hydrochloride. A critical review.
    JAMA, 1970, Aug-10, Volume: 213, Issue:6

    Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headac

1970

Trials

46 trials available for caffeine and Ache

ArticleYear
The efficacy of low-level laser therapy versus paracetamol-caffeine in controlling orthodontic separation pain and changes in the oral-health-related quality of life in Class I malocclusions: A 3-arm, randomized, placebo-controlled clinical trial.
    Journal of the World federation of orthodontists, 2022, Volume: 11, Issue:3

    Topics: Acetaminophen; Caffeine; Female; Humans; Low-Level Light Therapy; Male; Malocclusion, Angle Class I;

2022
Lack of Evidence for Blood Pressure Effects of Caffeine Added to Ibuprofen.
    Current drug safety, 2023, Volume: 18, Issue:1

    Topics: Analgesics, Non-Narcotic; Blood Pressure; Caffeine; Double-Blind Method; Humans; Ibuprofen; Pain; Pa

2023
Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial.
    Journal of pain and symptom management, 2013, Volume: 46, Issue:4

    Topics: Aged; Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Chemotherapy, Adjuvant; Doubl

2013
The effects of Red Bull energy drink compared with caffeine on cycling time-trial performance.
    International journal of sports physiology and performance, 2015, Volume: 10, Issue:7

    Topics: Adult; Athletic Performance; Beverages; Bicycling; Blood Glucose; Caffeine; Cross-Over Studies; Doub

2015
Caffeine improves performance in double poling during acute exposure to 2,000-m altitude.
    Journal of applied physiology (Bethesda, Md. : 1985), 2015, Dec-15, Volume: 119, Issue:12

    Topics: Adult; Altitude; Athletic Performance; Caffeine; Catecholamines; Central Nervous System Stimulants;

2015
Ergogenic effects of low doses of caffeine on cycling performance.
    International journal of sport nutrition and exercise metabolism, 2008, Volume: 18, Issue:3

    Topics: Adult; Bicycling; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Dose-Response Rel

2008
Effect of caffeine on quadriceps muscle pain during acute cycling exercise in low versus high caffeine consumers.
    International journal of sport nutrition and exercise metabolism, 2009, Volume: 19, Issue:2

    Topics: Adult; Analgesics; Bicycling; Caffeine; Central Nervous System Stimulants; Dose-Response Relationshi

2009
A preliminary investigation into the effect of coffee on hypolagesia associated with transcutaneous electrical nerve stimulation.
    Clinical physiology and functional imaging, 2009, Volume: 29, Issue:4

    Topics: Adult; Caffeine; Coffee; Double-Blind Method; Electric Stimulation; Electric Stimulation Therapy; Fe

2009
Caffeine does not attenuate experimentally induced ischemic pain in healthy subjects.
    Acta anaesthesiologica Scandinavica, 2009, Volume: 53, Issue:10

    Topics: Adult; Analgesics; Caffeine; Cross-Over Studies; Double-Blind Method; Female; Humans; Injections, In

2009
Randomized double-blind placebo-controlled crossover study of caffeine in patients with intermittent claudication.
    The British journal of surgery, 2010, Volume: 97, Issue:10

    Topics: Aged; Blood Pressure; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over Studies; Do

2010
Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo.
    Psychopharmacology, 2011, Volume: 215, Issue:3

    Topics: Adolescent; Adult; Analgesics; Arousal; Caffeine; Central Nervous System Stimulants; Double-Blind Me

2011
Dose-dependent effect of caffeine on reducing leg muscle pain during cycling exercise is unrelated to systolic blood pressure.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Adult; Blood Pressure; Caffeine; Dose-Response Relationship, Drug; Double-Blind Method; Exercise; He

2004
Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise.
    The journal of pain, 2007, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Electric Stimul

2007
Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen.
    Journal of clinical pharmacology, 2007, Volume: 47, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Area Under Curve; Caffeine; Central Nerv

2007
Effect of caffeine on leg-muscle pain during intense cycling exercise: possible role of anxiety sensitivity.
    International journal of sport nutrition and exercise metabolism, 2008, Volume: 18, Issue:2

    Topics: Adult; Analgesics; Anxiety; Bicycling; Caffeine; Central Nervous System Stimulants; Cross-Over Studi

2008
Analgesia following oral surgery: a comparative study of Solpadeine and a soluble form of dextropropoxyphene napsylate and paracetamol.
    The Journal of international medical research, 1983, Volume: 11, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Caffeine; Codeine; Dextropropoxyphene; Drug Combinations; Female;

1983
[Clinical evaluation of analgesics].
    Casopis lekaru ceskych, 1984, Jan-20, Volume: 123, Issue:3

    Topics: Adult; Aged; Analgesics; Antipyrine; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Comb

1984
Caffeine as an analgesic adjuvant.
    JAMA, 1984, Apr-06, Volume: 251, Issue:13

    Topics: Acetaminophen; Adjuvants, Pharmaceutic; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Dou

1984
Caffeine revisited.
    JAMA, 1984, Apr-06, Volume: 251, Issue:13

    Topics: Adjuvants, Pharmaceutic; Analgesics; Caffeine; Clinical Trials as Topic; Humans; Pain

1984
Distalgesic; safety and efficacy. Efficacy: UK experience.
    Human toxicology, 1984, Volume: 3 Suppl

    Topics: Acetaminophen; Apazone; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Drug Combin

1984
A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain.
    The Journal of international medical research, 1984, Volume: 12, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Double-Blind Method; Drug Combinations; Drug Ev

1984
[Analgesic, antipyretic and anti-rheumatic activity of 2 preparations evaluated in a multicenter clinical trial].
    La Clinica terapeutica, 1982, Dec-15, Volume: 103, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Child; Child, Preschool; Clinical Trials

1982
Double-blind comparisons of zomepirac and oxycodone with APC in cancer pain.
    Journal of clinical pharmacology, 1980, Volume: 20, Issue:4

    Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug C

1980
Clinical evaluation of zomepirac in the treatment of acute orthopedic pain.
    Journal of clinical pharmacology, 1980, Volume: 20, Issue:4

    Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug C

1980
[Comparison of the clinical activity of 2 analgesic formulations].
    La Clinica terapeutica, 1981, Mar-31, Volume: 96, Issue:6

    Topics: Adult; Analgesics; Antipyrine; Caffeine; Clinical Trials as Topic; Drug Combinations; Female; Humans

1981
Effects of caffeine on analgesia from transcutaneous electrical nerve stimulation.
    The New England journal of medicine, 1995, Aug-03, Volume: 333, Issue:5

    Topics: Adenosine; Adult; Caffeine; Double-Blind Method; Female; Humans; Male; Pain; Pain Measurement; Trans

1995
Analgesic effects of propyphenazone in comparison to its combination with caffeine.
    European journal of clinical pharmacology, 1996, Volume: 49, Issue:5

    Topics: Administration, Oral; Adult; Analgesia; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroida

1996
Effects of caffeine as an adjuvant to morphine in advanced cancer patients. A randomized, double-blind, placebo-controlled, crossover study.
    Journal of pain and symptom management, 2001, Volume: 21, Issue:5

    Topics: Analgesics, Opioid; Caffeine; Central Nervous System Stimulants; Cognition; Cross-Over Studies; Doub

2001
Relief of pain with oral medications.
    Australian and New Zealand journal of medicine, 1976, Volume: 6 Suppl 1

    Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Aspirin; Caffeine; Clinical Trials as Topic; C

1976
Aspirin and aspirin-caffeine in postpartum pain relief.
    Clinical pharmacology and therapeutics, 1978, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Aspirin; Caffeine; Clinical Trials as Topic; Double-Blind Method; Drug Combinatio

1978
The influence of 1,3,7-trimethyl-xanthine (caffeine) on the pain-caused dilation of pupil.
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:7

    Topics: Adult; Caffeine; Humans; Male; Pain; Pupil; Time Factors

1979
Acetaminophen extra strength capsules versus propoxphene compound-65 versus placebo: a double-blind study of effectiveness and safety.
    Current therapeutic research, clinical and experimental, 1975, Volume: 17, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Capsules; Clinical Trials as Topic; Dextropropo

1975
The effect of decreased caffeine consumption on benign proliferative breast disease: a randomized clinical trial.
    Surgery, 1987, Volume: 101, Issue:6

    Topics: Adult; Breast; Breast Diseases; Caffeine; Cell Division; Clinical Trials as Topic; Data Collection;

1987
[Combined analgesics in myalgia of the neck. A double-blind comparison of paracetamol and orphenadrine (Norgesic) and paracetamol and codeine (Paralgin forte) in general practice].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1986, Jan-20, Volume: 106, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double

1986
A comparative study of Propain and a dextropropoxyphene/paracetamol combination analgesic.
    The British journal of clinical practice, 1985, Volume: 39, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Caffeine; Codeine; Dextropropoxyphene; Diphenhydramine; Drug

1985
[Clinical testing of a new analgesic combination on cancer patients in chronic pain].
    Lakartidningen, 1973, Mar-07, Volume: 70, Issue:10

    Topics: Adult; Aged; Analgesics; Antipyrine; Aspirin; Caffeine; Clinical Trials as Topic; Dextropropoxyphene

1973
[EMA 3--a phenacetin-free combination with analgesic action].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1973, Jun-12, Volume: 62, Issue:24

    Topics: Acetaminophen; Adult; Aged; Allyl Compounds; Analgesics; Barbiturates; Caffeine; Clinical Trials as

1973
Relief of pain by oral medications. A controlled evaluation of analgesic combinations.
    JAMA, 1974, Jul-01, Volume: 229, Issue:1

    Topics: Administration, Oral; Analgesics; Aspirin; Azepines; Caffeine; Clinical Trials as Topic; Codeine; De

1974
[Analgetic effects on the stimulus threshold of the human tooth].
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:4

    Topics: Administration, Oral; Amides; Analgesics; Analysis of Variance; Aspirin; Caffeine; Clinical Trials a

1974
Evaluation of propoxyphene napsylate compound in post partum uterine cramping.
    Journal of medicine, 1974, Volume: 5, Issue:6

    Topics: Administration, Oral; Aspirin; Caffeine; Clinical Trials as Topic; Dextropropoxyphene; Female; Human

1974
[Clinical testing of a new combined analgesic for pain in the dental, jaw-, and facial regions].
    Medizinische Monatsschrift, 1974, Volume: 28, Issue:9

    Topics: Allyl Compounds; Aminopyrine; Analgesics; Aspirin; Barbiturates; Caffeine; Clinical Trials as Topic;

1974
Propoxyphene hydrochloride. A critical review.
    JAMA, 1970, Aug-10, Volume: 213, Issue:6

    Topics: Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Female; Headac

1970
Method, design, and analysis of a comparative study of analgetics.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1970, Volume: 3, Issue:4

    Topics: Acetaminophen; Analgesics; Analysis of Variance; Caffeine; Clinical Trials as Topic; Humans; Pain; P

1970
Method, design, and analysis of a comparative study of analgetics.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1970, Volume: 4, Issue:4

    Topics: Acetaminophen; Analgesics; Analysis of Variance; Caffeine; Clinical Trials as Topic; Humans; Pain; P

1970
Methodology of analgesic-muscle relaxant evaluation. Experience with orphenadrine citrate compound.
    Proceedings of the Western Pharmacology Society, 1965, Volume: 8

    Topics: Adult; Aspirin; Caffeine; Clinical Trials as Topic; Female; Humans; Male; Muscles; Orphenadrine; Pai

1965
An assessment of "Fiorinal" and FIPA in painful conditions of the hands.
    The Medical journal of Australia, 1970, Aug-15, Volume: 2, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics; Analysis of Variance; Arthritis, Rheumatoid; Aspirin; Caffei

1970

Other Studies

108 other studies available for caffeine and Ache

ArticleYear
Antinociceptive effects of novel A2B adenosine receptor antagonists.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:1

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Analgesia; Animals; Caffeine; Drug Synergism; Male; Mi

2004
Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study.
    Pain research & management, 2022, Volume: 2022

    Topics: Anesthetics, Local; Animals; Caffeine; Drug Interactions; Humans; Lidocaine; Pain; Rats; Rats, Wista

2022
Predictive models for determining treatment response to nonprescription acute medications in migraine: Results from the American Migraine Prevalence and Prevention Study.
    Headache, 2022, Volume: 62, Issue:6

    Topics: Acetaminophen; Caffeine; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Nonprescri

2022
The Medicinal Chemistry of Caffeine.
    Journal of medicinal chemistry, 2021, 06-10, Volume: 64, Issue:11

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Chemistry, Pharmaceutical; Glycogen Phosphorylase; Hu

2021
Decreased alertness due to sleep loss increases pain sensitivity in mice.
    Nature medicine, 2017, Volume: 23, Issue:6

    Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Chronic Diseas

2017
Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia.
    Scientific reports, 2017, 06-13, Volume: 7, Issue:1

    Topics: Acupuncture Analgesia; Animals; Caffeine; Central Nervous System Stimulants; Disease Models, Animal;

2017
Higher habitual dietary caffeine consumption is related to lower experimental pain sensitivity in a community-based sample.
    Psychopharmacology, 2018, Volume: 235, Issue:11

    Topics: Adult; Aged; Caffeine; Carbonated Beverages; Coffee; Energy Drinks; Feeding Behavior; Female; Humans

2018
Development of an Intervention to Reduce Pain and Prevent Syncope Related to Adolescent Vaccination.
    The Permanente journal, 2019, Volume: 23

    Topics: Adolescent; Breathing Exercises; Caffeine; Child; Drinking Water; Female; Humans; Interviews as Topi

2019
Influences of smoking and caffeine consumption on trigeminal pain processing.
    The journal of headache and pain, 2014, Jun-13, Volume: 15

    Topics: Adult; Brain Stem; Caffeine; Electric Stimulation; Evoked Potentials; Female; Humans; Male; Pain; Pa

2014
Potential of hydrogel-forming and dissolving microneedles for use in paediatric populations.
    International journal of pharmaceutics, 2015, Jul-15, Volume: 489, Issue:1-2

    Topics: Administration, Cutaneous; Adolescent; Analgesics; Animals; Caffeine; Child; Female; Humans; Hydroge

2015
Tramadol and Tramadol+Caffeine Synergism in the Rat Formalin Test Are Mediated by Central Opioid and Serotonergic Mechanisms.
    BioMed research international, 2015, Volume: 2015

    Topics: Analgesics, Opioid; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin;

2015
Antinociceptive Effect of Racemic Flurbiprofen and Caffeine Co-Administration in an Arthritic Gout-Type Pain in Rats.
    Drug development research, 2016, Volume: 77, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Caffeine; Disease Models, Animal

2016
Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.
    CPT: pharmacometrics & systems pharmacology, 2017, Volume: 6, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Chemical and Drug Induced Liver In

2017
Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.
    Neuroscience letters, 2008, Aug-01, Volume: 440, Issue:2

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System

2008
The antinociceptive interaction of anandamide and adenosine at the spinal level.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:3

    Topics: Adenosine; Analgesics; Animals; Arachidonic Acids; Caffeine; Dose-Response Relationship, Drug; Drug

2009
Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice.
    Life sciences, 2009, Aug-12, Volume: 85, Issue:7-8

    Topics: Acetic Acid; Analgesia; Analgesics; Animals; Behavior, Animal; Benzene Derivatives; Caffeine; Diseas

2009
Ryanodine receptors contribute to the induction of nociceptive input-evoked long-term potentiation in the rat spinal cord slice.
    Molecular pain, 2010, Jan-20, Volume: 6

    Topics: Afferent Pathways; Animals; Caffeine; Cells, Cultured; Electric Stimulation; Excitatory Postsynaptic

2010
Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice.
    Neuroscience letters, 2010, Apr-12, Volume: 473, Issue:3

    Topics: Adenosine A1 Receptor Antagonists; Analgesics; Animals; Caffeine; Carbamazepine; Drug Antagonism; Fe

2010
Acupuncture for mice.
    Nature, 2010, Jun-03, Volume: 465, Issue:7298

    Topics: Acupuncture Therapy; Adenosine; Animals; Caffeine; Humans; Mice; Models, Animal; Pain; Pain Manageme

2010
Caffeine lowers muscle pain during exercise in hot but not cool environments.
    Physiology & behavior, 2011, Mar-01, Volume: 102, Issue:3-4

    Topics: Adult; Bicycling; Caffeine; Cold Temperature; Exercise; Hot Temperature; Humans; Male; Muscle, Skele

2011
A hangover remedy for the holidays?
    Consumer reports, 2011, Volume: 76, Issue:1

    Topics: Alcohol Drinking; Aspirin; Caffeine; Headache; Humans; Pain; Pain Management

2011
Suspected opioid overdose case resolved by CYP2D6 genotyping.
    Therapeutic drug monitoring, 2012, Volume: 34, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Opioid; Caffeine; Codeine; Cytochrome P-450 CYP2D6; Drug Comb

2012
Evaluation of anti-nociceptive, anti-inflammatory and antipyretic activities of Artemisia scoparia hydromethanolic extract.
    Journal of ethnopharmacology, 2013, Jan-09, Volume: 145, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Artemisia; Caffeine; Carrageenan; Edema

2013
Regular intake of non-opioid analgesics is associated with an increased risk of restless legs syndrome in patients maintained on antidepressants.
    European journal of medical research, 2002, Aug-30, Volume: 7, Issue:8

    Topics: Adrenergic beta-Antagonists; Adult; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Anti

2002
Use of fiorinal for postpartum pain and discomfort.
    Rocky Mountain medical journal, 1957, Volume: 54, Issue:2

    Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Female; Humans; Pain; Postpartum Per

1957
Use of fiorinal for postpartum pain and discomfort.
    Rocky Mountain medical journal, 1957, Volume: 54, Issue:2

    Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Female; Humans; Pain; Postpartum Per

1957
Use of fiorinal for postpartum pain and discomfort.
    Rocky Mountain medical journal, 1957, Volume: 54, Issue:2

    Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Female; Humans; Pain; Postpartum Per

1957
Use of fiorinal for postpartum pain and discomfort.
    Rocky Mountain medical journal, 1957, Volume: 54, Issue:2

    Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Female; Humans; Pain; Postpartum Per

1957
Neurological agents in child psychiatry.
    Diseases of the nervous system, 1957, Volume: 18, Issue:2

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Caffeine; Child; Child Psychiatry; Humans; Morphine

1957
[On a new kind of analgesia with a new caffeine derivative].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1959, Jul-15, Volume: 14

    Topics: Analgesia; Caffeine; Headache; Pain; Pain Management; Rheumatic Diseases

1959
Analgesia for postpartum pain.
    Bulletin - Geisinger Medical Center, 1963, Volume: 15

    Topics: Analgesia; Analgesics; Aspirin; Caffeine; Codeine; Dextropropoxyphene; Female; Humans; Pain; Pain Ma

1963
DOUBLE-BLIND EVALUATION OF TWO ANALGESIC COMBINATIONS FOR PAIN AFTER MINOR ORAL SURGICAL PROCEDURES.
    Journal of oral surgery, anesthesia, and hospital dental service, 1963, Volume: 21

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Caffeine; Dextropropoxyphene; Double-Bl

1963
[GYNECOLOGIC PAIN SYNDROMES AND THEIR TREATMENT].
    Zentralblatt fur Gynakologie, 1964, Feb-22, Volume: 86

    Topics: Caffeine; Gynecology; Humans; Pain; Pelvis; Procaine; Somatoform Disorders; Syndrome

1964
[LIPOLYMPHANGIA].
    Dermatologische Wochenschrift, 1963, Jun-22, Volume: 147

    Topics: Adipose Tissue; Caffeine; Geriatrics; Humans; Knee; Pain; Procaine

1963
TREATMENT OF POSTPARTUM PAIN WITH FIORINAL.
    The Journal-lancet, 1964, Volume: 84

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Barbiturates; Biomedical Research; Caff

1964
[THE EFFECT OF SOME ANALGESICS ON DERMAL PAIN CAUSED BY HEAT IRRADIATION].
    Arzneimittel-Forschung, 1964, Volume: 14

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Caffeine; Hot Temperature; Pain; Pharmacology; P

1964
THE LATENCY OF PRICKING-PAIN SENSATION. I. THE EFFECT OF ACETOPHENETIDIN AND ANACIN. II. THE EFFECT OF REPEATED STIMULATION.
    The Journal of psychology, 1965, Volume: 59

    Topics: Aspirin; Biomedical Research; Body Temperature; Caffeine; Hot Temperature; Humans; Pain; Pharmacolog

1965
[EVALUATION OF THE SIEGMUND TEST OF THE ANALGESIC POWER OF SEVERAL DRUGS].
    Archivio italiano di scienze farmacologiche, 1963, Volume: 13

    Topics: Aminopyrine; Analgesics; Caffeine; Chlormezanone; Mice; Pain; Pharmacology; Phenylbutazone; Research

1963
[Toxic psychoses due to sedormid, saridon and contra-pain].
    Schweizer Archiv fur Neurologie und Psychiatrie. Archives suisses de neurologie et de psychiatrie. Archivio svizzero di neurologia e psichiatria, 1950, Volume: 65, Issue:1-2

    Topics: Analgesics; Antipyrine; Caffeine; Drug Combinations; Humans; Hypnotics and Sedatives; Pain; Phenacet

1950
Glomerular tip lesion associated with nonsteroidal anti-inflammatory drug-induced nephrotic syndrome.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:4

    Topics: Accidents, Traffic; Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Barbi

2005
Morphine reward in dopamine-deficient mice.
    Nature, 2005, Dec-08, Volume: 438, Issue:7069

    Topics: Analgesics, Opioid; Animals; Brain; Caffeine; Dihydroxyphenylalanine; Dopamine; Dose-Response Relati

2005
Modulation of paracetamol antinociception by caffeine and by selective adenosine A2 receptor antagonists in mice.
    European journal of pharmacology, 2006, Feb-15, Volume: 531, Issue:1-3

    Topics: Acetaminophen; Adenosine A2 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Caffeine; Centr

2006
Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine.
    Pharmacological research, 2006, Volume: 53, Issue:4

    Topics: Acetaminophen; Animals; Aspirin; Brain; Caffeine; Corpus Striatum; Dopamine; Male; Norepinephrine; P

2006
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
    Journal of pharmacological sciences, 2006, Volume: 100, Issue:4

    Topics: Analgesics; Animals; Caffeine; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response

2006
Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury.
    Neuroscience letters, 2006, Jul-10, Volume: 402, Issue:1-2

    Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship,

2006
Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug.
    Brain research, 2006, Sep-21, Volume: 1111, Issue:1

    Topics: Analgesics; Animals; Body Temperature; Brain; Caffeine; Central Nervous System Stimulants; Disease M

2006
Caffeine-related genital skin pain.
    Journal of lower genital tract disease, 2008, Volume: 12, Issue:1

    Topics: Adolescent; Aged; Caffeine; Central Nervous System Stimulants; Coffee; Female; Genital Diseases, Fem

2008
Prospective study of "fibrocystic breast disease" and caffeine consumption.
    Surgery, 1984, Volume: 96, Issue:3

    Topics: Adult; Aged; Breast; Caffeine; Coffee; Diet; Female; Fibrocystic Breast Disease; Humans; Menopause;

1984
[Gynecologic-obstetric pain therapy. Use of Lonarid N].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1980, Feb-20, Volume: 56, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Caffeine; Codeine; Drug Combinations; Dysmenorrhea; E

1980
Problems with the use of oxycodone compound in patients with chronic pain.
    Pain, 1981, Volume: 11, Issue:3

    Topics: Aspirin; Caffeine; Chronic Disease; Codeine; Dextropropoxyphene; Drug Combinations; Female; Humans;

1981
Aconitine-induced writhing as a method for assessing aspirin-like analgesic activity.
    Journal of pharmacological methods, 1980, Volume: 3, Issue:1

    Topics: Aconitine; Aconitum; Analgesics; Animals; Aspirin; Behavior, Animal; Caffeine; Drug Evaluation, Prec

1980
Relative potency of two preparations in two-way elimination of heterogeneity designs with multivariate responses.
    Biometrics, 1995, Volume: 51, Issue:3

    Topics: Acetaminophen; Analgesia; Analgesics; Biometry; Caffeine; Dentistry; Humans; Mathematics; Models, St

1995
Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms.
    Pain, 1995, Volume: 61, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Dioxanes; Drug Synergism; Formaldehyde; Hot Tempera

1995
Calcium modulation of morphine analgesia: role of calcium channels and intracellular pool calcium.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:1

    Topics: Animals; Caffeine; Calcium; Calcium Channels; Cell Compartmentation; Male; Membrane Potentials; Mice

1995
A device for automatic measurement of writhing and its application to the assessment of analgesic agents.
    Journal of pharmacological and toxicological methods, 1994, Volume: 32, Issue:2

    Topics: Acetates; Acetic Acid; Aminopyrine; Analgesics; Animals; Behavior, Animal; Caffeine; Disease Models,

1994
Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:10

    Topics: Animals; Aspirin; Caffeine; Drug Synergism; Female; Gentisates; Hindlimb; Hydroxybenzoates; Pain; Ra

1994
Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:7

    Topics: Acetaminophen; Administration, Oral; Animals; Caffeine; Drug Combinations; Drug Synergism; Female; H

1993
[A fixed combination of acetylsalicylic acid and paracetamol is absolutely effective. Interview by Dr. rer. nat. Anita Schweiger].
    Fortschritte der Medizin, 1996, Feb-10, Volume: 114, Issue:4

    Topics: Analgesics; Aspirin; Barbiturates; Caffeine; Drug Combinations; Humans; Pain; Pain Measurement; Phen

1996
Silicone breast implants and drug-induced arthralgia.
    Plastic and reconstructive surgery, 1997, Volume: 99, Issue:5

    Topics: Arthralgia; Breast Implants; Caffeine; Cyclizine; Diagnosis, Differential; Drug Combinations; Ergota

1997
Adenosine receptors. Knockouts anxious for new therapy.
    Nature, 1997, Aug-14, Volume: 388, Issue:6643

    Topics: Adenosine; Animals; Caffeine; Drug Therapy; Mice; Mice, Knockout; Pain; Receptors, Purinergic P1

1997
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.
    Nature, 1997, Aug-14, Volume: 388, Issue:6643

    Topics: Adenosine; Aggression; Animals; Blood Pressure; Brain; Caffeine; Cloning, Molecular; Heart Rate; Hum

1997
Caffeine induces central cholinergic analgesia.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:5

    Topics: Analgesia; Animals; Caffeine; Central Nervous System Stimulants; Cholinergic Agents; Dose-Response R

1997
[The use of the preparation Solpadeine in dental practice].
    Stomatologiia, 1997, Volume: 76, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caff

1997
Stress-dependent antinociceptive effects of carbamazepine: a study in stressed and nonstressed rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 1998, Volume: 22, Issue:1

    Topics: Adenosine; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Caffeine; Carbamazepine; Cerebra

1998
Oscillatory effects of repeated morphine on shock-induced hypoalgesia and beta-endorphin.
    Synapse (New York, N.Y.), 1998, Volume: 30, Issue:1

    Topics: Analysis of Variance; Animals; beta-Endorphin; Caffeine; Electroshock; Lithium Chloride; Male; Morph

1998
Inhibition of strychnine-allodynia is mediated by spinal adenosine A1- but not A2-receptors in the rat.
    Brain research, 1998, Oct-12, Volume: 808, Issue:1

    Topics: Adenosine; Animals; Blood Pressure; Caffeine; Heart Rate; Injections, Spinal; Male; Pain; Phenethyla

1998
On the analgesic effect of sodium diclofenac in pain-induced functional impairment in the rat.
    Proceedings of the Western Pharmacology Society, 1998, Volume: 41

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Diclofenac; Dose-Response Re

1998
Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine.
    Pain, 1999, Volume: 80, Issue:1-2

    Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Dose-Resp

1999
Effect of coadministration of caffeine and either adenosine agonists or cyclic nucleotides on ketorolac analgesia.
    European journal of pharmacology, 1999, Jul-21, Volume: 377, Issue:2-3

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Administration, Topical; Analgesics, Non-Narcotic; Animals;

1999
Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
    Pain, 1999, Volume: 82, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Caffeine; Desipramine; Drug Evaluation, Precli

1999
Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor.
    European journal of pharmacology, 1999, Nov-19, Volume: 384, Issue:2-3

    Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Analgesics; Animals; Anti-Inf

1999
Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain.
    European journal of pharmacology, 2000, Jul-07, Volume: 399, Issue:2-3

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System

2000
"No, Duke. No divorce".
    Medical economics, 2001, Aug-20, Volume: 78, Issue:16

    Topics: Aspirin; Caffeine; Deception; Drug Combinations; Drug Prescriptions; Humans; Male; Middle Aged; Oxyc

2001
Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions.
    European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Caffeine; Disease Models

2001
Quantitative design of optimal analgesic combination of acetaminophen, caffeine, and butalbital.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Barbiturates; Caffeine; Carrageenan; Dose-Response

2001
[Neurophysiologic analysis of the effect of phenamine and caffeine or cortical neurons].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1976, Volume: 62, Issue:12

    Topics: Amphetamine; Animals; Auditory Perception; Caffeine; Cats; Caudate Nucleus; Cerebral Cortex; Electri

1976
Letter: The clinical course of patients with analgesic nephropathy.
    Canadian Medical Association journal, 1975, Aug-09, Volume: 113, Issue:3

    Topics: Analgesics; Aspirin; Caffeine; Codeine; Creatinine; Female; Follow-Up Studies; Humans; Kidney; Kidne

1975
Pharmacokinetic/pharmacodynamic analysis of the interaction between acetaminophen and caffeine.
    Proceedings of the Western Pharmacology Society, 1992, Volume: 35

    Topics: Acetaminophen; Administration, Oral; Animals; Caffeine; Chromatography, High Pressure Liquid; Drug S

1992
Pain and discomfort associated with film-screen mammography.
    Journal of the National Cancer Institute, 1991, Dec-04, Volume: 83, Issue:23

    Topics: Anxiety; Breast; Caffeine; Female; Humans; Mammography; Menopause; Menstrual Cycle; Middle Aged; Pai

1991
[Chronic use of analgesics].
    Sozial- und Praventivmedizin, 1990, Volume: 35, Issue:4-5

    Topics: Adult; Analgesics; Caffeine; Case-Control Studies; Drug Combinations; Drug Prescriptions; Female; Hu

1990
Assessment of the role of A1/A2 adenosine receptors mediating the purine antinociception, motor and autonomic function in the rat spinal cord.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Autonomic Nervous System; Blood Pressure; Caf

1989
Caffeine restriction as initial treatment for breast pain.
    The Nurse practitioner, 1989, Volume: 14, Issue:2

    Topics: Adolescent; Adult; Aged; Caffeine; Coffee; Female; Fibrocystic Breast Disease; Humans; Middle Aged;

1989
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.
    Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 333, Issue:1

    Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricula

1986
Patient discomfort during screen-film mammography.
    Radiology, 1988, Volume: 168, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Caffeine; Female; Humans; Mammography; Menstruatio

1988
[A new analgesic in pediatric practice: Sig 8304].
    La Clinica terapeutica, 1986, Jun-30, Volume: 117, Issue:6

    Topics: Adolescent; Analgesics; Antipyrine; Benzoates; Caffeine; Child; Child, Preschool; Drug Combinations;

1986
Morphine--caffeine analgesic interaction in rats.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:9

    Topics: Analgesics; Animals; Caffeine; Drug Synergism; Electric Stimulation; Hot Temperature; Male; Morphine

1985
Calcific tendonitis of the longus colli muscle: a cause of atraumatic neck pain.
    Annals of emergency medicine, 1985, Volume: 14, Issue:10

    Topics: Adult; Aspirin; Barbiturates; Caffeine; Calcinosis; Drug Combinations; Female; Humans; Male; Oxycodo

1985
[Evaluation of the analgesic activity of a preconstituted combination of acetylsalicylic acid, paracetamol and caffeine].
    La Clinica terapeutica, 1985, Oct-31, Volume: 115, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aspirin; Caffeine; Drug Combinations; Drug Evaluation; Female; Hum

1985
[Letter: Huneke's neural therapy?].
    Munchener medizinische Wochenschrift (1950), 1973, Dec-14, Volume: 115, Issue:50

    Topics: Caffeine; Complementary Therapies; Germany, West; Humans; Pain; Procaine

1973
A comparison of propoxyphene HCl (Darvon) and an analgesic mixture (Percogesic) in pain relief after gingivectomy.
    Journal of oral therapeutics and pharmacology, 1967, Volume: 4, Issue:3

    Topics: Acetaminophen; Adult; Analgesics; Atropine; Caffeine; Dextropropoxyphene; Female; Gingivectomy; Hist

1967
[Clinical study of a new antalgic: Propofan].
    Lyon medical, 1972, Jan-23, Volume: 227, Issue:2

    Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Caffeine; Dextropropoxyphene; Female; Headache; His

1972
[A study of sensation by the double simultaneous stimulation method].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1974, Volume: 74, Issue:9

    Topics: Adult; Amphetamine; Brain Diseases; Caffeine; Epinephrine; Female; Humans; Hypesthesia; Methods; Pai

1974
[Octadon N].
    Therapie der Gegenwart, 1974, Volume: 113, Issue:7

    Topics: Analgesics; Aspirin; Caffeine; Drug Combinations; Germany, West; Headache; Humans; Migraine Disorder

1974
[Intensification of effect using a combination of analgesic drugs in a split-tablet].
    Therapie der Gegenwart, 1974, Volume: 113, Issue:11

    Topics: Analgesics; Antipyrine; Caffeine; Drug Combinations; Humans; Mandelic Acids; Pain; Salicylamides; Sa

1974
[Clinical experiences with Fortalidon in painful conditions in gynecology and obstetrics].
    Fortschritte der Medizin, 1972, Sep-21, Volume: 90, Issue:26

    Topics: Aminopyrine; Analgesics; Aspirin; Barbiturates; Caffeine; Codeine; Drug Combinations; Female; Genita

1972
[Comparative studies on the analgesic effect of diphenyl-methoxy-benzylaminopropane-hydrochloride (ST 4250)].
    Wiener klinische Wochenschrift, 1973, Jul-06, Volume: 85, Issue:27

    Topics: Analgesics; Benzhydryl Compounds; Benzyl Compounds; Caffeine; Humans; Methyl Ethers; Pain; Phenaceti

1973
The effects of caffeine and theophylline on nociceptive stimulation in the rat.
    Acta pharmacologica et toxicologica, 1973, Volume: 32, Issue:1

    Topics: Animals; Caffeine; Central Nervous System; Dose-Response Relationship, Drug; Electric Stimulation; I

1973
Effects of caffeine on the absorption and analgesic efficacy of paracetamol in rats.
    Pharmacology, 1973, Volume: 10, Issue:1

    Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Caffeine; Depression, Chemical; Dose-Respo

1973
[On the treatment of inflammatory and degenerative diseases of the musculosketetal system with Vertebran].
    Deutsches medizinisches Journal, 1968, Dec-05, Volume: 19, Issue:23

    Topics: Atropine; Bone Diseases; Caffeine; Ergoloid Mesylates; Humans; Joint Diseases; Muscular Diseases; Pa

1968
[Practical experience with Neuramag sine].
    Zeitschrift fur Allgemeinmedizin, 1972, Apr-30, Volume: 48, Issue:12

    Topics: Acetaminophen; Adult; Aged; Aspirin; Caffeine; Chemical Phenomena; Chemistry; Drug Combinations; Fem

1972
[The pain syndrome of the edentulous alveolar crest and its treatment].
    Revue de stomatologie et de chirurgie maxillo-faciale, 1969, Volume: 70, Issue:2

    Topics: Administration, Topical; Alveolar Process; Aminopyrine; Anti-Inflammatory Agents; Aspirin; Caffeine;

1969
[Study of a new combination of analgesic substances].
    Hospital (Rio de Janeiro, Brazil), 1965, Volume: 67, Issue:5

    Topics: Acetaminophen; Adult; Caffeine; Female; Humans; Male; Pain; Salicylamides

1965
4-Dimethyl-amino methyl-2-methyl 1,3 dioxolane--a new potent analgesic agent.
    Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 179, Issue:1

    Topics: Analgesics; Animals; Aspirin; Caffeine; Codeine; Dextropropoxyphene; Dioxoles; Electric Stimulation;

1969
[Pain from the viewpoint of the general practitioner. Experiences with a new analgesic].
    Medizinische Monatsschrift, 1969, Volume: 23, Issue:8

    Topics: Adolescent; Adult; Aged; Amobarbital; Analgesics; Antipyrine; Caffeine; Family Practice; Humans; Mid

1969
[Comparative examination of analgesics by means of threshold value in thermal skin irritation as criterion of the analgetic effect].
    Wiener klinische Wochenschrift, 1969, Aug-29, Volume: 81, Issue:35

    Topics: Analgesics; Burns; Caffeine; Humans; Pain; Phenacetin; Phenethylamines; Time Factors

1969
[Ambulatory experiences with a new analgesic].
    Zeitschrift fur Allgemeinmedizin, 1969, Nov-20, Volume: 45, Issue:32

    Topics: Adult; Aged; Ambulatory Care; Aminopyrine; Amobarbital; Analgesics; Antipyrine; Caffeine; Female; Hu

1969
[A comparative study of the neuronal reactions of the paleo- and neo-cortex of the guinea pig brain].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1970, Volume: 56, Issue:3

    Topics: Animals; Caffeine; Cerebral Cortex; Chlorpromazine; Electrophysiology; Guinea Pigs; Hearing; Hippoca

1970
Individual differences in pain threshold and level of arousal.
    British journal of psychology (London, England : 1953), 1967, Volume: 58, Issue:1

    Topics: Arousal; Body Temperature; Caffeine; Extraversion, Psychological; Female; Humans; Introversion, Psyc

1967
Primary erythermalgia. Report of a patient treated with methysergide maleate.
    JAMA, 1968, Mar-18, Volume: 203, Issue:12

    Topics: Aspirin; Caffeine; Codeine; Edema; Erythromelalgia; Female; Humans; Maleates; Methysergide; Middle A

1968
[The influence of caffeine on the analgesic effects of salicylamide].
    Arzneimittel-Forschung, 1965, Volume: 15, Issue:9

    Topics: Animals; Caffeine; Drug Synergism; Pain; Rabbits; Salicylamides

1965
[Apropos of pain in herpes zoster. Treatment with a new drug complex with a base of D-propoxyphene].
    Lyon medical, 1966, Sep-04, Volume: 216, Issue:36

    Topics: Adult; Aged; Aspirin; Caffeine; Dextropropoxyphene; Herpes Zoster; Humans; Male; Middle Aged; Pain;

1966