Page last updated: 2024-10-24

caffeine and Abnormalities, Drug-Induced

caffeine has been researched along with Abnormalities, Drug-Induced in 125 studies

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
"Maternal use of "social drugs" such as caffeine, ethanol and tobacco in pregnancy is on increase- -worldwide."8.85Peripartum implications of caffeine intake in pregnancy: is there cause for concern? ( Kuczkowski, KM, 2009)
"Alcohol and caffeine consumption during pregnancy are risk factors for fetal outcome."7.67Neural tube defects in early rat embryos following maternal treatment with ethanol and caffeine. ( Persaud, TV; Ross, CP, 1989)
"Caffeine, when administered in moderate (30 mg/kg X d) or high (60 mg/kg X d) doses during pregnancy, was shown to cause significant fetal growth retardation of both sexes."7.67Effects of caffeine administered during pregnancy on fetal development and subsequent function in the adult rat: prolonged effects on a second generation. ( Jabbour, H; Mehrabani, PA; Pollard, I, 1987)
"Use of alcohol, caffeine, and nicotine during pregnancy can have serious consequences for the fetus, such as low birth weight, congenital anomalies, or even death."7.66Alcohol, caffeine, and nicotine as factors in pregnancy. ( Lodge, JR; Weathersbee, PS, 1979)
"A risk analysis of in utero caffeine exposure is presented utilizing epidemiological studies and animal studies dealing with congenital malformation, pregnancy loss, and weight reduction."4.87Evaluation of the reproductive and developmental risks of caffeine. ( Brent, RL; Christian, MS; Diener, RM, 2011)
"Maternal use of "social drugs" such as caffeine, ethanol and tobacco in pregnancy is on increase- -worldwide."4.85Peripartum implications of caffeine intake in pregnancy: is there cause for concern? ( Kuczkowski, KM, 2009)
" Food and Drug Administration of 1981, a review of human epidemiological studies finds no adverse effect of caffeine on pregnancy outcome."4.77Caffeine consumption and the risk of reproductive hazards. ( Leviton, A, 1988)
"In recent years, chemotherapy with caffeine has manifested potently high efficacy against osteosarcoma, although adverse effects have been observed."3.81Development of tumor-specific caffeine-potentiated chemotherapy using a novel drug delivery system with Span 80 nano-vesicles. ( Iwasaki, T; Kidani, T; Masumoto, J; Miura, H; Miyazaki, T; Nakamura, A; Nakata, H; Sakayama, K, 2015)
"Dose-response of the teratogenic effect of caffeine (CA) and the potential role of facial hematomas in the pathogenesis of caffeine-induced cleft palate were investigated using CD1 mice treated with 150, 200, or 250 mg CA/kg i."3.69Interaction of dimethylsulfoxide and arachidonic acid with the teratogenic effects of caffeine in mice. ( Brimer, GE; Fraipier, BL; Frappier, BL; Reddy, CS; Reddy, RV, 1994)
"In this study, fetal joint abnormalities caused by cytosine arabinoside, caffeine, sodium salicylate, and retinyl acetate administration during pregnancy, were investigated."3.69Demonstration of congenital anomalies in the joints of the forelimbs and hindlimbs caused by several pharmacological agents. ( Erdoğan, D; Kadioğlu, D; Peker, T, 1996)
"Alcohol and caffeine consumption during pregnancy are risk factors for fetal outcome."3.67Neural tube defects in early rat embryos following maternal treatment with ethanol and caffeine. ( Persaud, TV; Ross, CP, 1989)
"Ergotamine exposure during pregnancy has been suggested to cause birth defects which have a vascular disruptive aetiology."3.67Birth defects following maternal exposure to ergotamine, beta blockers, and caffeine. ( Goldstein, DA; Hughes, HE, 1988)
"Caffeine, when administered in moderate (30 mg/kg X d) or high (60 mg/kg X d) doses during pregnancy, was shown to cause significant fetal growth retardation of both sexes."3.67Effects of caffeine administered during pregnancy on fetal development and subsequent function in the adult rat: prolonged effects on a second generation. ( Jabbour, H; Mehrabani, PA; Pollard, I, 1987)
"From day 6 to day 20 of pregnancy, rats were treated with caffeine in a total daily dose of 10 or 100 mg/kg by gavage, either as a single bolus dose or as four divided doses given at 3-hr intervals throughout the day."3.67Effects of administering caffeine to pregnant rats either as a single daily dose or as divided doses four times a day. ( McElhatton, PR; Smith, SE; Sullivan, FM, 1987)
"Caffeine was administered intraperitoneally to CD-1 mice on days 11 and 12 of pregnancy at doses of 80-250 mg/kg."3.66Caffeine-induced limb malformations: description of malformations and quantitation of placental transfer. ( Scott, WJ, 1983)
" We raise the hypothesis that Cafergot (1 mg ergotamine tartrate and 100 mg caffeine) might represent a vascular disruptive teratogenic agent during pregnancy."3.66Jejunal atresia associated with Cafergot ingestion during pregnancy. ( Graham, JM; Hoefnagel, D; Marin-Padilla, M, 1983)
"When caffeine (1,3,7-trimethylxanthine) was introduced into the diet of rats throughout pregnancy and lactation at levels of consumption of 10 mg/kg/day, offspring of successive pregnancies showed growth reductions."3.66Effects of maternal caffeine ingestion on neonatal growth in rats. ( Court, JM; Dunlop, M, 1981)
"1 In Charles River CD1 mice, a single dose of 100 mg kg-1 caffeine injected intraperitoneally on day 14 of pregnancy caused a low incidence of cleft palate in the fetuses."3.66Acute studies to investigate the mechanism of action of caffeine as a teratogen in mice. ( Elmazar, MM; McElhatton, PR; Sullivan, FM, 1981)
"Use of alcohol, caffeine, and nicotine during pregnancy can have serious consequences for the fetus, such as low birth weight, congenital anomalies, or even death."3.66Alcohol, caffeine, and nicotine as factors in pregnancy. ( Lodge, JR; Weathersbee, PS, 1979)
"Among all the birth defects, maternal caffeine consumption was associated with a higher risk of cardiovascular defects, [odds ratio (OR) 1."2.72Maternal intake of caffeinated products and birth defects: a systematic review and meta-analysis of observational studies. ( Li, W; Luo, L; Mu, D; Qiu, X; Qu, Y; Shi, J; Tang, J; Wang, H; Xia, B; Xiong, T; Yue, Y; Zeng, Y, 2021)
"Caffeine is a widespread natural methylaxanthine which easily crosses the placenta."2.41[Teratogenic and embryotoxic effects of caffeine: facts and hypotheses]. ( Burdan, F, 2000)
"Caffeine is a central nervous system stimulant that has come under increasing scrutiny due to its effects on the health and mental health of those who consume it."2.37Caffeine: implications of recent research for clinical practice. ( Wells, SJ, 1984)
" The present study was undertaken to evaluate the reproductive toxic effect of meclizine and caffeine combination."1.40Prenatal and developmental toxicity study of meclizine and caffeine combination in female albino Wistar rats. ( Alvin, JM; Sandeep, M, 2014)
"Clomipramine was injected at 40 mg/kg and 80 mg/kg to the second and third groups, respectively."1.39The role of clomipramine in potentiating the teratogenic effects of caffeine in pregnant rats: a histopathological study. ( Bakhtiarian, A; Giorgi, M; Nabavi, SM; Nikoui, V; Ostadhadi, S; Takzare, N, 2013)
"Caffeine is an alkaloid widely consumed by humans."1.31Caffeine decreases the occurrence of cadmium-induced forelimb ectrodactyly in C57BL/6J mice. ( Beck, SL; Lutz, J, 2000)
"Valproic acid, which is an isomer of 2-EXHA, also produced similar defects, and was approximately twice as potent as 2-EHXA."1.27Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine. ( Randall, JL; Ritter, EJ; Ritter, JM; Scott, WJ, 1987)
"Caffeine has previously been demonstrated to be teratogenic in mice, causing primarily limb reduction defects and cleft palate."1.27Interactions between caffeine and adenosine agonists in producing embryo resorptions and malformations in mice. ( Clark, RL; Cusick, WA; Eschbach, K; Heyse, JF, 1987)
" Dose-response data and microcinematographic observations suggest that caffeine induced cardiac anomalies by a direct toxic effect on the embryo rather than by altering cardiac cell function."1.27Pulmonary stenosis with ventricular septal defect, common aorticopulmonary trunk, and dextroposition of the aorta: morphologic and qualitative physiologic effects in caffeine-treated chick embryos. ( Bruyere, HJ; Gilbert, EF; Gilbert, JE; Nishikawa, T; Uno, H, 1986)
" A dosage of eighty mg/kg/d was more effective than 20 mg/kg/d beta-NF in decreasing malformations, suggesting that stimulation of metabolism and caffeine-induced teratogenicity are inversely related."1.27Reduction of caffeine teratogenicity in mice by inducing maternal drug metabolism with beta-naphthoflavone. ( Randall, JL; Scott, WJ; York, RG, 1985)
"In a previous experiment, fetopathic effects of caffeine were significantly reduced by pretreatment with propranolol at dosage levels of 2."1.26Mitigation of caffeine-induced fetopathy in mice by pretreatment with beta-adrenergic blocking agents. ( Fujii, T, 1976)

Research

Studies (125)

TimeframeStudies, this research(%)All Research%
pre-199088 (70.40)18.7374
1990's19 (15.20)18.2507
2000's10 (8.00)29.6817
2010's6 (4.80)24.3611
2020's2 (1.60)2.80

Authors

AuthorsStudies
Yue, Y1
Li, W1
Tang, J1
Zeng, Y1
Xiong, T1
Qiu, X1
Shi, J1
Wang, H1
Xia, B1
Luo, L1
Qu, Y1
Mu, D1
Félix, L1
Lobato-Freitas, C1
Monteiro, SM1
Venâncio, C1
Nikoui, V1
Ostadhadi, S1
Takzare, N1
Nabavi, SM1
Giorgi, M1
Bakhtiarian, A1
Nakata, H1
Miyazaki, T1
Iwasaki, T1
Nakamura, A1
Kidani, T1
Sakayama, K1
Masumoto, J1
Miura, H1
Sandeep, M1
Alvin, JM1
Kuczkowski, KM1
Peck, JD1
Leviton, A3
Cowan, LD1
Robinson, JF1
van Beelen, VA1
Verhoef, A1
Renkens, MF1
Luijten, M1
van Herwijnen, MH1
Westerman, A1
Pennings, JL1
Piersma, AH1
Brent, RL1
Christian, MS1
Diener, RM1
Cowan, L1
Nawrot, P1
Jordan, S1
Eastwood, J1
Rotstein, J1
Hugenholtz, A1
Feeley, M1
WINBERG, J1
FRASER, FC1
KNOCHE, C1
KOENIG, J1
KUEHNE, P1
Bech, BH1
Olsen, J1
Bruyere, HJ3
Fallon, JF1
Gilbert, EF3
Kalter, H1
Warkany, J1
James, JE1
Stirling, KP1
Wells, SJ1
Hill, LM1
Kleinberg, F1
Kusama, T2
Yoshizawa, Y2
Cordero, JF1
Oakley, GP1
Fujii, T8
Nakatsuka, T2
Hanada, S1
Ritter, EJ2
Scott, WJ5
Wilson, JG1
Mathinos, PR1
Randall, JL4
Tanaka, H3
Nakazawa, K2
Arima, M1
Iwasaki, S1
Kurppa, K1
Holmberg, PC1
Kuosma, E1
Saxén, L1
Todorov, S1
Gilani, SH3
Giovinazzo, JJ1
Persaud, TV7
Miller, SA1
Harris, JE1
Palm, PE2
Arnold, EP2
Nick, MS1
Valentine, JR1
Doerfler, TE1
Nomura, T2
Graham, JM1
Marin-Padilla, M1
Hoefnagel, D1
Nigro, N1
Skalko, RG2
Kwasigroch, TE1
Renwick, JH2
Rosenberg, L1
Mitchell, AA1
Shapiro, S1
Slone, D1
Kelsey, FO1
Lee, H1
Nagele, RG1
Pietrolungo, JF1
Streissguth, AP1
Barr, HM1
Martin, DC1
Nolen, GA1
Dunlop, M1
Court, JM1
Oser, BL1
Ford, RA1
Elmazar, MM1
McElhatton, PR2
Sullivan, FM2
Lechat, MF1
Borlee, I1
Bouckaert, A1
Misson, C1
Barkovich, AJ1
Rowley, H1
Bollen, A1
Iwase, T1
Arishima, K1
Ohyama, N1
Inazawa, K1
Iwase, Y1
Ikeda, Y1
Shirai, M1
Yamamoto, M1
Somiya, H1
Eguchi, Y1
Reddy, RV1
Reddy, CS1
Frappier, BL1
Brimer, GE1
Fraipier, BL1
Sakamoto, MK1
Mima, S1
Kihara, T1
Matsuo, T1
Yasuda, Y1
Tanimura, T1
Golding, J1
Hinds, TS1
West, WL1
Knight, EM1
Harland, BF1
Erdoğan, D1
Kadioğlu, D1
Peker, T1
Marret, S1
Gressens, P1
Van-Maele-Fabry, G1
Picard, J1
Evrard, P1
Fort, DJ2
Stover, EL2
Bantle, JA2
Rayburn, JR1
Hull, MA1
Finch, RA1
Burton, DT1
Turley, SD1
Dawson, DA2
Linder, G1
Buchwalter, D1
Dumont, JN1
Kumsher-King, M1
Gaudet-Hull, AM1
Propst, TL1
Faulkner, BC1
Vollmuth, TA1
Murray, FJ1
Colomina, MT2
Sanchez, DJ2
Esparza, JL1
Domingo, JL2
Lutz, J1
Beck, SL2
Burdan, F2
Albina, ML1
Ishikawa, S1
Cheung, MO1
Hodach, RJ1
Weathersbee, PS1
Lodge, JR1
Perrins, NM1
Niles, AM1
Rachwall, PC1
Leyczek, JC1
Teague, KW1
Kensler, CJ2
von Kreybig, T1
Czok, G1
Terada, M1
Nishmura, H1
Yielding, LW1
Riley, TL1
Yielding, KL1
Dlugosz, L1
Bracken, MB1
Fadel, RA1
Kurishita, A3
Ihara, T2
Gilbody, JS1
Urbano, CM1
Benowitz, NL1
Cerrato, PL1
Ross, CP2
Muther, TF1
Al-Hachim, GM1
Hemminki, K1
Vineis, P1
Sugiura, N1
Kai, M1
Zhai, SD1
Chen, MQ1
Dong, LP1
Jia, XR1
Nash, J1
Ritter, JM1
Lancaster, JS1
Coles, CD1
Platzman, KA1
Smith, IE1
Falek, A1
Matsuoka, R1
Uno, H2
Kerr, CS1
Nadal-Ginard, B1
Heller, J1
Hughes, HE1
Goldstein, DA1
Clark, RL1
Eschbach, K1
Cusick, WA1
Heyse, JF1
Pollard, I1
Jabbour, H1
Mehrabani, PA1
Abbott, PJ1
Smith, SE1
Auerbach, BA1
Słowikowska, MG1
Lenarczyk, M1
Gajewski, AK1
Collins, TF1
Welsh, JJ1
Black, TN1
Whitby, KE1
O'Donnell, MW1
Nishikawa, T1
Gilbert, JE1
York, RG2
Bertrand, M1
Girod, J1
Rigaud, MF1
Nishimura, H5
Bartel, H2
Mielczarek, J1
Thayer, PS1
Mulvihill, JJ1
Kozaczenko, J1
Sasaki, H1
Snigórska, B1
Mandelcorn, MS1
Merin, S1
Cardarelli, J1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial[NCT02832336]Phase 1/Phase 216 participants (Actual)Interventional2016-10-01Completed
Phase III Study Comparing Coristina® D to Resfenol® in the Symptomatic Treatment of Common Cold[NCT02735070]Phase 3366 participants (Anticipated)Interventional2016-09-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

25 reviews available for caffeine and Abnormalities, Drug-Induced

ArticleYear
Maternal intake of caffeinated products and birth defects: a systematic review and meta-analysis of observational studies.
    Critical reviews in food science and nutrition, 2021, Volume: 61, Issue:22

    Topics: Abnormalities, Drug-Induced; Caffeine; Congenital Abnormalities; Female; Humans; Odds Ratio

2021
Peripartum implications of caffeine intake in pregnancy: is there cause for concern?
    Revista espanola de anestesiologia y reanimacion, 2009, Volume: 56, Issue:10

    Topics: Abnormalities, Drug-Induced; Adult; Animals; Beverages; Caffeine; Dose-Response Relationship, Drug;

2009
Evaluation of the reproductive and developmental risks of caffeine.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2011, Volume: 92, Issue:2

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Caffeine; Congenital Abnormalities; Fem

2011
A review of the literature relating caffeine consumption by women to their risk of reproductive hazards.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:9

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Caffeine; Central Nervous System Stimulan

2002
Effects of caffeine on human health.
    Food additives and contaminants, 2003, Volume: 20, Issue:1

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Bone and Bones; Caffeine; Calcium; Cardiovascula

2003
Congenital malformations (second of two parts).
    The New England journal of medicine, 1983, Mar-03, Volume: 308, Issue:9

    Topics: Abnormalities, Drug-Induced; Air Pollutants, Occupational; Alcohol Drinking; Anesthetics; Anticoagul

1983
Caffeine: a survey of some of the known and suspected deleterious effects of habitual use.
    British journal of addiction, 1983, Volume: 78, Issue:3

    Topics: Abnormalities, Drug-Induced; Anxiety Disorders; Behavior Therapy; Caffeine; Coffee; Diagnosis, Diffe

1983
Caffeine: implications of recent research for clinical practice.
    The American journal of orthopsychiatry, 1984, Volume: 54, Issue:3

    Topics: Abnormalities, Drug-Induced; Affective Symptoms; Animals; Blood Pressure; Brain; Caffeine; Child; De

1984
Effects of drugs and chemicals on the fetus and newborn (1).
    Mayo Clinic proceedings, 1984, Volume: 59, Issue:10

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Behavior; Caffeine; Dicyclomine; Doxylamine; Drug

1984
Drug exposure during pregnancy: some epidemiologic considerations.
    Clinical obstetrics and gynecology, 1983, Volume: 26, Issue:2

    Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations;

1983
Reproduction and caffeine consumption--a literature review.
    Early human development, 1995, Aug-30, Volume: 43, Issue:1

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Administration, Oral; Animals; Caffeine; Chick E

1995
The effect of caffeine on pregnancy outcome variables.
    Nutrition reviews, 1996, Volume: 54, Issue:7

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Dose-Response Relationship, Drug; Fema

1996
[Teratogenic and embryotoxic effects of caffeine: facts and hypotheses].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2000, Volume: 9, Issue:52

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Humans; Maternal-Fetal Exchange; Pregnancy;

2000
[Teratology, 40 years after the thalidomide tragedy].
    Ginekologia polska, 2001, Volume: 72, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Abortion, Spontaneous; Animals; Caffe

2001
Reproductive effects of caffeine: a review and theoretical analysis.
    Epidemiologic reviews, 1992, Volume: 14

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Caffeine; Female; Humans; Infertility;

1992
Effects of maternal drug addiction on the fetus.
    Adverse drug reactions and toxicological reviews, 1991,Summer, Volume: 10, Issue:2

    Topics: Abnormalities, Drug-Induced; Alcoholism; Amphetamines; Benzodiazepines; Caffeine; Cocaine; Female; F

1991
Clinical pharmacology of caffeine.
    Annual review of medicine, 1990, Volume: 41

    Topics: Abnormalities, Drug-Induced; Caffeine; Cardiovascular Diseases; Humans; Mental Disorders; Risk Facto

1990
Teratogenicity of caffeine; a review.
    European journal of obstetrics, gynecology, and reproductive biology, 1989, Volume: 31, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Coffee; Female; Humans; Infant, Newborn; Pregnancy;

1989
Extrapolation of the evidence on teratogenicity of chemicals between humans and experimental animals: chemicals other than drugs.
    Teratogenesis, carcinogenesis, and mutagenesis, 1985, Volume: 5, Issue:4

    Topics: Abnormalities, Drug-Induced; Anesthetics; Animals; Caffeine; Cannabinoids; Carbon Monoxide; Copper;

1985
Reproductive and teratological risks of caffeine.
    Anatomischer Anzeiger, 1988, Volume: 167, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Humans; Pregnancy

1988
Caffeine consumption and the risk of reproductive hazards.
    The Journal of reproductive medicine, 1988, Volume: 33, Issue:2

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Female; Humans; Infant, Low Birth Weig

1988
What do we know about the risks of caffeine consumption in pregnancy?
    British journal of addiction, 1987, Volume: 82, Issue:8

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Female; Humans; Infant, Low Birth Weig

1987
Caffeine: a toxicological overview.
    The Medical journal of Australia, 1986, Nov-17, Volume: 145, Issue:10

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Carbonated Beverages; Central Nervous System; Choles

1986
[Brain dysfunction induced by maternal factors].
    No to shinkei = Brain and nerve, 1985, Volume: 37, Issue:11

    Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Anticonvulsants; Brain; Brain Disease

1985
[Effect of drugs, ingested by the mother during pregnancy, on the fetus].
    Ginekologia polska, 1969, Volume: 40, Issue:3

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Female; Humans; Meclizine; Pregnancy;

1969

Trials

2 trials available for caffeine and Abnormalities, Drug-Induced

ArticleYear
Selected birth defects in relation to caffeine-containing beverages.
    JAMA, 1982, Mar-12, Volume: 247, Issue:10

    Topics: Abnormalities, Drug-Induced; Beverages; Caffeine; Cleft Lip; Cleft Palate; Clinical Trials as Topic;

1982
Regulatory aspects of teratology: role of the Food and Drug Administration.
    Teratology, 1982, Volume: 25, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Clinical Trials as Topic; Congenital Abnormalities;

1982

Other Studies

98 other studies available for caffeine and Abnormalities, Drug-Induced

ArticleYear
24-Epibrassinolide modulates the neurodevelopmental outcomes of high caffeine exposure in zebrafish (Danio rerio) embryos.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2021, Volume: 249

    Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Brassinosteroids; Caffeine; Embryo, Nonmamma

2021
The role of clomipramine in potentiating the teratogenic effects of caffeine in pregnant rats: a histopathological study.
    TheScientificWorldJournal, 2013, Volume: 2013

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Clomipramine; Dose-Response Relationship, Drug; Drug

2013
Development of tumor-specific caffeine-potentiated chemotherapy using a novel drug delivery system with Span 80 nano-vesicles.
    Oncology reports, 2015, Volume: 33, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Benzoates; Bone

2015
Prenatal and developmental toxicity study of meclizine and caffeine combination in female albino Wistar rats.
    Indian journal of experimental biology, 2014, Volume: 52, Issue:12

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Caffeine; Dose-Response Rel

2014
A review of the epidemiologic evidence concerning the reproductive health effects of caffeine consumption: a 2000-2009 update.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:10

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Central Nervous System Stimulants; Fem

2010
Embryotoxicant-specific transcriptomic responses in rat postimplantation whole-embryo culture.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Abnormalities, Drug-Induced; Acetates; Animals; Caffeine; Embryo Culture Techniques; Embryo Implanta

2010
Risks for birth defects or low birth weight: air pollution...medications...and caffeine.
    Child health alert, 2002, Volume: 20

    Topics: Abnormalities, Drug-Induced; Air Pollutants; Caffeine; Central Nervous System Stimulants; Congenital

2002
[ANALYSIS OF THE POSSIBLE RELATION OF FETAL DAMAGE AND DRUGS. V. PRELIMINARY STUDY ON THE INFLUENCE OF 4 ANTIEMETICS ON FETAL DEVELOPMENT].
    Svenska lakartidningen, 1964, Mar-25, Volume: 61

    Topics: Abnormalities, Drug-Induced; Abortion, Induced; Abortion, Spontaneous; Antiemetics; Birth Weight; Ca

1964
EXPERIMENTAL TERATOGENESIS IN RELATION TO CONGENITAL MALFORMATIONS IN MAN.
    World-wide abstracts of general medicine, 1964, Volume: 7

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Caffeine; Cortisone; Insulin; Lagomorph

1964
[ON THE PRENATAL TOXICITY OF DIPHENYLPYRALINE 8-CHLOROTHEOPHYLLINATE WITH REFERENCE TO EXPERIENCES WITH THALIDOMIDE AND CAFFEINE].
    Arzneimittel-Forschung, 1964, Volume: 14

    Topics: Abnormalities, Drug-Induced; Anti-Allergic Agents; Caffeine; Fetal Death; Histamine H1 Antagonists;

1964
[THE PROCEDURES FOR THE TESTING OF TERATOGENIC EFFECTS TAKE SHAPE].
    Zeitschrift fur arztliche Fortbildung (Berlin), 1965, Volume: 54

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Haplorhini; Humans; Pregnancy; Sodium Chlori

1965
[Pregnancy and caffeine].
    Ugeskrift for laeger, 2003, Nov-17, Volume: 165, Issue:47

    Topics: Abnormalities, Drug-Induced; Caffeine; Central Nervous System Stimulants; Coffee; Embryonic and Feta

2003
Does caffeine in pregnancy cause birth defects?
    Child health alert, 2006, Volume: 24

    Topics: Abnormalities, Drug-Induced; Caffeine; Central Nervous System Stimulants; Female; Humans; Pregnancy

2006
External malformations in chick embryos following concomitant administration of methylxanthines and beta-adrenomimetic agents: 1. Gross pathologic features.
    Teratology, 1983, Volume: 28, Issue:2

    Topics: Abnormalities, Drug-Induced; Adrenergic beta-Agonists; Animals; Caffeine; Chick Embryo; Dose-Respons

1983
The synergistic effects of radiation and caffeine on embryonic development in mice.
    Journal of radiation research, 1984, Volume: 25, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Caffeine; Embryonic and Feta

1984
Potentiating effects of caffeine on teratogenicity of alkylating agents in mice.
    Teratology, 1983, Volume: 28, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Alkylating Agents; Animals; Antibioti

1983
Potentiating effects of methylxanthines on teratogenicity of mitomycin C in mice.
    Teratology, 1983, Volume: 28, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Antibiotics, Antineoplastic; Caffeine; Drug Synergism; Female;

1983
Potentiative interactions between caffeine and various teratogenic agents.
    Teratology, 1982, Volume: 25, Issue:1

    Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Caffeine; Cycloheximide; Dactinomycin; Dose-Res

1982
Caffeine and its dimethylxanthines and fetal cerebral development in rat.
    Brain & development, 1984, Volume: 6, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Caffeine; Female; Fetus; Maternal-Fetal Exchange; Pregn

1984
Coffee consumption during pregnancy and selected congenital malformations: a nationwide case-control study.
    American journal of public health, 1983, Volume: 73, Issue:12

    Topics: Abnormalities, Drug-Induced; Caffeine; Coffee; Female; Finland; Humans; Pilot Projects; Pregnancy; R

1983
[Relationship between the placental-fetal index (PFI) and the toxic and teratogenic effect in the fetuses of mothers treated with sedalgin during pregnancy].
    Eksperimentalna meditsina i morfologiia, 1983, Volume: 22, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Caffeine; Codeine; Drug Combinations; Female; Fetus;

1983
Caffeine-induced limb malformations: description of malformations and quantitation of placental transfer.
    Teratology, 1983, Volume: 28, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Dose-Response Relationship, Drug; Female; Limb Defor

1983
Embryopathic effects of caffeine in the chick.
    Experimental pathology, 1983, Volume: 23, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chick Embryo; Hemorrhage; Intestines; Microphthalmos

1983
Drugs in the food supply.
    Current concepts in nutrition, 1983, Volume: 12

    Topics: Abnormalities, Drug-Induced; Animals; Behavior; Caffeine; Female; Food Additives; Food Supply; Human

1983
Two-year toxicity/carcinogenicity study of fresh-brewed coffee in rats initially exposed in utero.
    Toxicology and applied pharmacology, 1984, Volume: 74, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Caffeine; Calcium; Carcinogens; F

1984
Caffeine labeling. Council on Scientific Affairs. American Medical Association.
    JAMA, 1984, Aug-10, Volume: 252, Issue:6

    Topics: Abnormalities, Drug-Induced; Behavior; Cacao; Caffeine; Carbonated Beverages; Coffee; Female; Fibroc

1984
Comparative inhibiting effects of methylxanthines on urethan-induced tumors, malformations, and presumed somatic mutations in mice.
    Cancer research, 1983, Volume: 43, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Caffeine; DNA Repair; Lung Neoplasms; M

1983
Jejunal atresia associated with Cafergot ingestion during pregnancy.
    Clinical pediatrics, 1983, Volume: 22, Issue:3

    Topics: Abnormalities, Drug-Induced; Adult; Caffeine; Drug Combinations; Ergotamine; Female; Humans; Infant,

1983
[Do congenital malformations caused by caffeine exist?].
    Minerva pediatrica, 1983, Jan-31, Volume: 35, Issue:1-2

    Topics: Abnormalities, Drug-Induced; Caffeine; Humans; Infant, Newborn

1983
The interaction of chemicals during pregnancy: an update.
    Biological research in pregnancy and perinatology, 1983, Volume: 4, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Bromodeoxyuridine; Caffeine; Drug Interactions; Female; Fetus;

1983
Food and malformation.
    The Practitioner, 1982, Volume: 226, Issue:1373

    Topics: Abnormalities, Drug-Induced; Caffeine; Congenital Abnormalities; Female; Fetal Alcohol Spectrum Diso

1982
Toxic and teratologic effects of caffeine on explanted early chick embryos.
    Teratology, 1982, Volume: 25, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Caffeine; Chick Embryo; Culture Techniques; Dose-Respon

1982
Offspring effects and pregnancy complications related to self-reported maternal alcohol use.
    Developmental pharmacology and therapeutics, 1982, Volume: 5, Issue:1-2

    Topics: Abnormalities, Drug-Induced; Alcohol Drinking; Apgar Score; Caffeine; Female; Fetus; Heart Rate; Hum

1982
The effect of brewed and instant coffee on reproduction and teratogenesis in the rat.
    Toxicology and applied pharmacology, 1981, Volume: 58, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Caffeine; Coffee; Female; Fetal D

1981
Effects of maternal caffeine ingestion on neonatal growth in rats.
    Biology of the neonate, 1981, Volume: 39, Issue:3-4

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Birth Weight; Body Weight; Caffeine; Female;

1981
Third international caffeine workshop.
    Nutrition reviews, 1981, Volume: 39, Issue:4

    Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Bone Development; Caffeine; Dose-Response Relatio

1981
Caffeine: an update.
    Drug and chemical toxicology, 1981, Volume: 4, Issue:4

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Behavior; Caffeine; Child; Child, Preschool

1981
Acute studies to investigate the mechanism of action of caffeine as a teratogen in mice.
    Human toxicology, 1981, Volume: 1, Issue:1

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex; Amniotic Fluid; Animals; Caffeine; Cleft Palate; Cortic

1981
Caffeine study.
    Science (New York, N.Y.), 1980, Mar-21, Volume: 207, Issue:4437

    Topics: Abnormalities, Drug-Induced; Caffeine; Female; Humans; Infant, Newborn; Pregnancy; Teratogens

1980
Correlation of prenatal events with the development of polymicrogyria.
    AJNR. American journal of neuroradiology, 1995, Volume: 16, Issue:4 Suppl

    Topics: Abnormalities, Drug-Induced; Brain; Caffeine; Cerebral Cortex; Child; Child, Preschool; Ergotamine;

1995
In vitro study of teratogenic effects of caffeine on cultured rat embryos and embryonic cells.
    The Journal of veterinary medical science, 1994, Volume: 56, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cell Differentiation; Cell Division; Cells, Cultured

1994
Interaction of dimethylsulfoxide and arachidonic acid with the teratogenic effects of caffeine in mice.
    Natural toxins, 1994, Volume: 2, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Arachidonic Acid; Caffeine; Cleft Palate; Corticosterone; Dime

1994
Developmental toxicity of caffeine in the larvae of Xenopus laevis.
    Teratology, 1993, Volume: 47, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Dose-Response Relationship, Drug; Embryo, Nonmammali

1993
Demonstration of congenital anomalies in the joints of the forelimbs and hindlimbs caused by several pharmacological agents.
    Anatomia, histologia, embryologia, 1996, Volume: 25, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agen

1996
Caffeine-induced disturbances of early neurogenesis in whole mouse embryo cultures.
    Brain research, 1997, Oct-31, Volume: 773, Issue:1-2

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Embryo, Mammalian; Embryonic and Fetal Development;

1997
Phase III interlaboratory study of FETAX, Part 2: interlaboratory validation of an exogenous metabolic activation system for frog embryo teratogenesis assay--Xenopus (FETAX).
    Drug and chemical toxicology, 1998, Volume: 21, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Caffeine; Cyclophosphamide; Lethal Dose 50;

1998
Evaluation of the developmental toxicity of caffeine and caffeine metabolites using the frog embryo teratogenesis assay--Xenopus (FETAX).
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1998, Volume: 36, Issue:7

    Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Caffeine; Central Nervous System Stimulants

1998
Prenatal effects of caffeine and restraint stress in mice.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1999, Volume: 220, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Congenital Abnormalities; Eating; Embryonic and Feta

1999
Caffeine decreases the occurrence of cadmium-induced forelimb ectrodactyly in C57BL/6J mice.
    Teratology, 2000, Volume: 62, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Cadmium; Caffeine; Central Nervous System Stimulants; Crosses,

2000
Interactions in developmental toxicology: combined action of restraint stress, caffeine, and aspirin in pregnant mice.
    Teratology, 2001, Volume: 63, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Caffeine; Embryonic and Fetal Development; Female; Ma

2001
The effects of methylxanthines on catecholamine-stimulated and normal chick embryos.
    Teratology, 1977, Volume: 16, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Abnormalities, Drug-Induced; Animals; Aortic Aneurysm; Aortic A

1977
Similarity of the mechanism of chemical carcinogen-initiated teratogenesis and carcinogenesis in mice.
    Cancer research, 1977, Volume: 37, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Abnormalities, Drug-Induced; Animals; Caffeine; Carcinogens; Congenital Ab

1977
Alcohol, caffeine, and nicotine as factors in pregnancy.
    Postgraduate medicine, 1979, Volume: 66, Issue:3

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Alcohol Drinking; Animals; Birth Weight; Caffe

1979
The effect of 5-bromodeoxyuridine on mouse limb development: a scanning electron microscope study.
    Acta embryologiae experimentalis, 1977, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Bromodeoxyuridine; Caffeine; Extremities; Female; Limb Deformi

1977
Evaluation of the teratogenic potential of fresh-brewed coffee and caffeine in the rat.
    Toxicology and applied pharmacology, 1978, Volume: 44, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Body Weight; Caffeine; Coffee; Cricetinae; Female; Le

1978
[Teratogenic and mutagenic studies with caffeine in the animal experiment].
    Zeitschrift fur Ernahrungswissenschaft, 1976, Volume: 15, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Benzoates; Caffeine; Female; Lethal Dos

1976
Mitigation of caffeine-induced fetopathy in mice by pretreatment with beta-adrenergic blocking agents.
    Japanese journal of pharmacology, 1976, Volume: 26, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fetus; Mice; Mice, Inbred ICR; Pregnancy; Pr

1976
Mitigation of caffeine-induced teratogenicity in mice by prior chronic caffeine ingestion.
    Teratology, 1975, Volume: 12, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fetal Death; Gestational Age; Mice; Mice, In

1975
Preliminary study of caffeine and chloroquine enhancement of x-ray induced birth defects.
    Biochemical and biophysical research communications, 1976, Feb-23, Volume: 68, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chloroquine; Drug Synergism; Female; Male; Mice; Mic

1976
Effects of alcohol and caffeine on cultured whole rat embryos.
    Acta anatomica, 1992, Volume: 144, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Embryo, Mammalian; Embryonic and Fetal Development;

1992
Hyperploid cells in the limb buds of rats and 5-azacytidine-induced digital deformities.
    Teratogenesis, carcinogenesis, and mutagenesis, 1991, Volume: 11, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Azacitidine; Caffeine; Female; Hindlimb; Humans; Male; Polyplo

1991
Potentiating effect of caffeine on the teratogenicity of acetazolamide in C57BL/6J mice.
    Teratology, 1991, Volume: 44, Issue:3

    Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Caffeine; Drug Synergism; Female; Humans; Male;

1991
Caffeine: how much is too much?
    RN, 1990, Volume: 53, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Caffeine; Cardiovascular System; Female; Humans; Infant, Newborn

1990
Craniofacial and limb development in early rat embryos following in utero exposure to ethanol and caffeine.
    Anatomischer Anzeiger, 1990, Volume: 170, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Ethanol; Extremities; Facial Bones; Female; Limb Def

1990
Inhibitory effect of caffeine on 5-azacytidine-induced digital malformations in the rat.
    Teratology, 1987, Volume: 35, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Azacitidine; Caffeine; Dose-Response Relationship, Drug; Femal

1987
Caffeine and reduction of fetal ossification in the rat: fact or artifact?
    Teratology, 1988, Volume: 37, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Dose-Response Relationship, Drug; Female; Gestationa

1988
Histological study of cell death in digital malformations induced by 5-azacytidine: suppressive effect of caffeine.
    Teratology, 1989, Volume: 39, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Azacitidine; Caffeine; Cell Survival; Dose-Response Relationsh

1989
Neural tube defects in early rat embryos following maternal treatment with ethanol and caffeine.
    Anatomischer Anzeiger, 1989, Volume: 169, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Central Nervous System; Ethanol; Female; Neural Tube

1989
Caffeine cubes.
    Lancet (London, England), 1988, Apr-09, Volume: 1, Issue:8589

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Humans; Mice; Pregnancy

1988
Combined effects of radiation and caffeine on embryonic development in mice.
    Radiation research, 1989, Volume: 117, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Body Weight; Caffeine; Embry

1989
[Antagonistic effects of ascorbic acid on caffeine-induced embryotoxic and teratogenic activities in rats].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Caffeine; Female; Pregnancy; Rats; Rats, Inbred

1986
Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine.
    Teratology, 1987, Volume: 35, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Caproates; Diethylhexyl Phthalate; Drug Synergism; F

1987
Contributions of maternal alcohol, caffeine, and cigarette use to neonatal status.
    NIDA research monograph, 1987, Volume: 76

    Topics: Abnormalities, Drug-Induced; Caffeine; Ethanol; Female; Humans; Infant, Newborn; Pregnancy; Smoking

1987
Caffeine induces cardiac and other malformations in the rat.
    American journal of medical genetics. Supplement, 1987, Volume: 3

    Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Caffeine; Female; Heart Defects, Congenital; L

1987
Birth defects following maternal exposure to ergotamine, beta blockers, and caffeine.
    Journal of medical genetics, 1988, Volume: 25, Issue:6

    Topics: Abnormalities, Drug-Induced; Caffeine; Ergotamine; Female; Humans; Infant, Newborn; Migraine Disorde

1988
Interactions between caffeine and adenosine agonists in producing embryo resorptions and malformations in mice.
    Toxicology and applied pharmacology, 1987, Volume: 91, Issue:3

    Topics: 2-Chloroadenosine; Abnormalities, Drug-Induced; Adenosine; Animals; Body Weight; Caffeine; Drug Admi

1987
Effects of caffeine administered during pregnancy on fetal development and subsequent function in the adult rat: prolonged effects on a second generation.
    Journal of toxicology and environmental health, 1987, Volume: 22, Issue:1

    Topics: 3-Hydroxysteroid Dehydrogenases; Abnormalities, Drug-Induced; Animals; Birth Weight; Caffeine; Embry

1987
Effects of administering caffeine to pregnant rats either as a single daily dose or as divided doses four times a day.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1987, Volume: 25, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Caffeine; Dose-Response Relationship, Drug; Femal

1987
Teratogenic effects in mice exposed to single dose of X-rays and prolonged administration of caffeine during pregnancy.
    Roczniki Panstwowego Zakladu Higieny, 1986, Volume: 37, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Caffeine; Female; Maternal-F

1986
Coadministration of methylxanthines and inhibitor compounds potentiates teratogenicity in Xenopus embryos.
    Teratology, 1987, Volume: 35, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cycloheximide; Cytarabine; Drug Synergism; Embryo, N

1987
Potential reversibility of skeletal effects in rats exposed in utero to caffeine.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1987, Volume: 25, Issue:9

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Body Weight; Bone and Bones; Caffeine; Drink

1987
Chick embryonic development following exposure to caffeine and nicotine.
    Anatomischer Anzeiger, 1986, Volume: 161, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chick Embryo; Dose-Response Relationship, Drug; Gest

1986
Pulmonary stenosis with ventricular septal defect, common aorticopulmonary trunk, and dextroposition of the aorta: morphologic and qualitative physiologic effects in caffeine-treated chick embryos.
    Teratology, 1986, Volume: 33, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chick Embryo; Cineradiography; Heart; Heart Defects,

1986
Teratogenicity of paraxanthine (1,7-dimethylxanthine) in C57BL/6J mice.
    Teratology, 1986, Volume: 34, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cleft Palate; Dose-Response Relationship, Drug; Fema

1986
Caffeine.
    Boletin de la Asociacion Medica de Puerto Rico, 1985, Volume: 77, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fibrocystic Breast Disease; Half-Life; Heart

1985
Reduction of caffeine teratogenicity in mice by inducing maternal drug metabolism with beta-naphthoflavone.
    Teratology, 1985, Volume: 31, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Benzoflavones; beta-Naphthoflavone; Caffeine; Cytochrome P-450

1985
Embryopathic effects of ethanol and caffeine in the chick.
    Anatomischer Anzeiger, 1985, Volume: 158, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chick Embryo; Drug Synergism; Ethanol; Mortality

1985
[Ectrodactyly caused by caffeine in rodents. Role of specific and genetic factors].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1970, Volume: 164, Issue:7

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fingers; Mice; Rabbits; Rats; Rodentia

1970
Reduction in frequency of fetopathic effects of caffeine in mice by pretreatment with propranolol.
    Teratology, 1974, Volume: 10, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Catecholamines; Female; Fetus; Humans; Maternal-Feta

1974
Proceedings: Prevention of embryopathic effects of caffeine in mice by pretreatment with propranolol.
    Japanese journal of pharmacology, 1974, Volume: 24, Issue:0

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Embryo, Mammalian; Female; Humans; Mice; Pregnancy;

1974
[Teratogenic effect of caffeine on the development of extremities in mice].
    Ginekologia polska, 1973, Volume: 44, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Gestational Age; Limb Deformities, Congenita

1973
Exposure of four generations of mice to caffeine in drinking water.
    Toxicology and applied pharmacology, 1973, Volume: 25, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Breeding; Caffeine; Dose-Response Relationship, D

1973
Caffeine as teratogen and mutagen.
    Teratology, 1973, Volume: 8, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chromosome Aberrations; Female; Fetal Death; Fetus;

1973
Adverse effects of prolonged administration of caffeine on rat fetus.
    Toxicology and applied pharmacology, 1972, Volume: 22, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Blood Cell Count; Body Weight; Caffeine; Diet; Edema; Esophagu

1972
Teratogenicity of caffeine in mice related to its mode of administration.
    Japanese journal of pharmacology, 1969, Volume: 19, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cleft Palate; Clubfoot; Dyspnea; Fingers; Gestationa

1969
[Studies on the teratogenic influence of caffeine on the fetuses of white mice].
    Folia morphologica, 1970, Volume: 29, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Caffeine; Female; Limb Deformities, Congenit

1970
Teratogenic actions of some methylated xanthines in mice.
    Okajimas folia anatomica Japonica, 1969, Volume: 46, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fetus; Injections, Intraperitoneal; Male; Mi

1969
Goldenhar's syndrome and phocomelia. Case report and etiologic considerations.
    American journal of ophthalmology, 1971, Volume: 72, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Threatened; Aspirin; Caffeine; Child

1971