caffeine has been researched along with Abnormalities, Drug-Induced in 125 studies
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Maternal use of "social drugs" such as caffeine, ethanol and tobacco in pregnancy is on increase- -worldwide." | 8.85 | Peripartum implications of caffeine intake in pregnancy: is there cause for concern? ( Kuczkowski, KM, 2009) |
| "Alcohol and caffeine consumption during pregnancy are risk factors for fetal outcome." | 7.67 | Neural tube defects in early rat embryos following maternal treatment with ethanol and caffeine. ( Persaud, TV; Ross, CP, 1989) |
| "Caffeine, when administered in moderate (30 mg/kg X d) or high (60 mg/kg X d) doses during pregnancy, was shown to cause significant fetal growth retardation of both sexes." | 7.67 | Effects of caffeine administered during pregnancy on fetal development and subsequent function in the adult rat: prolonged effects on a second generation. ( Jabbour, H; Mehrabani, PA; Pollard, I, 1987) |
| "Use of alcohol, caffeine, and nicotine during pregnancy can have serious consequences for the fetus, such as low birth weight, congenital anomalies, or even death." | 7.66 | Alcohol, caffeine, and nicotine as factors in pregnancy. ( Lodge, JR; Weathersbee, PS, 1979) |
| "A risk analysis of in utero caffeine exposure is presented utilizing epidemiological studies and animal studies dealing with congenital malformation, pregnancy loss, and weight reduction." | 4.87 | Evaluation of the reproductive and developmental risks of caffeine. ( Brent, RL; Christian, MS; Diener, RM, 2011) |
| "Maternal use of "social drugs" such as caffeine, ethanol and tobacco in pregnancy is on increase- -worldwide." | 4.85 | Peripartum implications of caffeine intake in pregnancy: is there cause for concern? ( Kuczkowski, KM, 2009) |
| " Food and Drug Administration of 1981, a review of human epidemiological studies finds no adverse effect of caffeine on pregnancy outcome." | 4.77 | Caffeine consumption and the risk of reproductive hazards. ( Leviton, A, 1988) |
| "In recent years, chemotherapy with caffeine has manifested potently high efficacy against osteosarcoma, although adverse effects have been observed." | 3.81 | Development of tumor-specific caffeine-potentiated chemotherapy using a novel drug delivery system with Span 80 nano-vesicles. ( Iwasaki, T; Kidani, T; Masumoto, J; Miura, H; Miyazaki, T; Nakamura, A; Nakata, H; Sakayama, K, 2015) |
| "Dose-response of the teratogenic effect of caffeine (CA) and the potential role of facial hematomas in the pathogenesis of caffeine-induced cleft palate were investigated using CD1 mice treated with 150, 200, or 250 mg CA/kg i." | 3.69 | Interaction of dimethylsulfoxide and arachidonic acid with the teratogenic effects of caffeine in mice. ( Brimer, GE; Fraipier, BL; Frappier, BL; Reddy, CS; Reddy, RV, 1994) |
| "In this study, fetal joint abnormalities caused by cytosine arabinoside, caffeine, sodium salicylate, and retinyl acetate administration during pregnancy, were investigated." | 3.69 | Demonstration of congenital anomalies in the joints of the forelimbs and hindlimbs caused by several pharmacological agents. ( Erdoğan, D; Kadioğlu, D; Peker, T, 1996) |
| "Alcohol and caffeine consumption during pregnancy are risk factors for fetal outcome." | 3.67 | Neural tube defects in early rat embryos following maternal treatment with ethanol and caffeine. ( Persaud, TV; Ross, CP, 1989) |
| "Ergotamine exposure during pregnancy has been suggested to cause birth defects which have a vascular disruptive aetiology." | 3.67 | Birth defects following maternal exposure to ergotamine, beta blockers, and caffeine. ( Goldstein, DA; Hughes, HE, 1988) |
| "Caffeine, when administered in moderate (30 mg/kg X d) or high (60 mg/kg X d) doses during pregnancy, was shown to cause significant fetal growth retardation of both sexes." | 3.67 | Effects of caffeine administered during pregnancy on fetal development and subsequent function in the adult rat: prolonged effects on a second generation. ( Jabbour, H; Mehrabani, PA; Pollard, I, 1987) |
| "From day 6 to day 20 of pregnancy, rats were treated with caffeine in a total daily dose of 10 or 100 mg/kg by gavage, either as a single bolus dose or as four divided doses given at 3-hr intervals throughout the day." | 3.67 | Effects of administering caffeine to pregnant rats either as a single daily dose or as divided doses four times a day. ( McElhatton, PR; Smith, SE; Sullivan, FM, 1987) |
| "Caffeine was administered intraperitoneally to CD-1 mice on days 11 and 12 of pregnancy at doses of 80-250 mg/kg." | 3.66 | Caffeine-induced limb malformations: description of malformations and quantitation of placental transfer. ( Scott, WJ, 1983) |
| " We raise the hypothesis that Cafergot (1 mg ergotamine tartrate and 100 mg caffeine) might represent a vascular disruptive teratogenic agent during pregnancy." | 3.66 | Jejunal atresia associated with Cafergot ingestion during pregnancy. ( Graham, JM; Hoefnagel, D; Marin-Padilla, M, 1983) |
| "When caffeine (1,3,7-trimethylxanthine) was introduced into the diet of rats throughout pregnancy and lactation at levels of consumption of 10 mg/kg/day, offspring of successive pregnancies showed growth reductions." | 3.66 | Effects of maternal caffeine ingestion on neonatal growth in rats. ( Court, JM; Dunlop, M, 1981) |
| "1 In Charles River CD1 mice, a single dose of 100 mg kg-1 caffeine injected intraperitoneally on day 14 of pregnancy caused a low incidence of cleft palate in the fetuses." | 3.66 | Acute studies to investigate the mechanism of action of caffeine as a teratogen in mice. ( Elmazar, MM; McElhatton, PR; Sullivan, FM, 1981) |
| "Use of alcohol, caffeine, and nicotine during pregnancy can have serious consequences for the fetus, such as low birth weight, congenital anomalies, or even death." | 3.66 | Alcohol, caffeine, and nicotine as factors in pregnancy. ( Lodge, JR; Weathersbee, PS, 1979) |
| "Among all the birth defects, maternal caffeine consumption was associated with a higher risk of cardiovascular defects, [odds ratio (OR) 1." | 2.72 | Maternal intake of caffeinated products and birth defects: a systematic review and meta-analysis of observational studies. ( Li, W; Luo, L; Mu, D; Qiu, X; Qu, Y; Shi, J; Tang, J; Wang, H; Xia, B; Xiong, T; Yue, Y; Zeng, Y, 2021) |
| "Caffeine is a widespread natural methylaxanthine which easily crosses the placenta." | 2.41 | [Teratogenic and embryotoxic effects of caffeine: facts and hypotheses]. ( Burdan, F, 2000) |
| "Caffeine is a central nervous system stimulant that has come under increasing scrutiny due to its effects on the health and mental health of those who consume it." | 2.37 | Caffeine: implications of recent research for clinical practice. ( Wells, SJ, 1984) |
| " The present study was undertaken to evaluate the reproductive toxic effect of meclizine and caffeine combination." | 1.40 | Prenatal and developmental toxicity study of meclizine and caffeine combination in female albino Wistar rats. ( Alvin, JM; Sandeep, M, 2014) |
| "Clomipramine was injected at 40 mg/kg and 80 mg/kg to the second and third groups, respectively." | 1.39 | The role of clomipramine in potentiating the teratogenic effects of caffeine in pregnant rats: a histopathological study. ( Bakhtiarian, A; Giorgi, M; Nabavi, SM; Nikoui, V; Ostadhadi, S; Takzare, N, 2013) |
| "Caffeine is an alkaloid widely consumed by humans." | 1.31 | Caffeine decreases the occurrence of cadmium-induced forelimb ectrodactyly in C57BL/6J mice. ( Beck, SL; Lutz, J, 2000) |
| "Valproic acid, which is an isomer of 2-EXHA, also produced similar defects, and was approximately twice as potent as 2-EHXA." | 1.27 | Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine. ( Randall, JL; Ritter, EJ; Ritter, JM; Scott, WJ, 1987) |
| "Caffeine has previously been demonstrated to be teratogenic in mice, causing primarily limb reduction defects and cleft palate." | 1.27 | Interactions between caffeine and adenosine agonists in producing embryo resorptions and malformations in mice. ( Clark, RL; Cusick, WA; Eschbach, K; Heyse, JF, 1987) |
| " Dose-response data and microcinematographic observations suggest that caffeine induced cardiac anomalies by a direct toxic effect on the embryo rather than by altering cardiac cell function." | 1.27 | Pulmonary stenosis with ventricular septal defect, common aorticopulmonary trunk, and dextroposition of the aorta: morphologic and qualitative physiologic effects in caffeine-treated chick embryos. ( Bruyere, HJ; Gilbert, EF; Gilbert, JE; Nishikawa, T; Uno, H, 1986) |
| " A dosage of eighty mg/kg/d was more effective than 20 mg/kg/d beta-NF in decreasing malformations, suggesting that stimulation of metabolism and caffeine-induced teratogenicity are inversely related." | 1.27 | Reduction of caffeine teratogenicity in mice by inducing maternal drug metabolism with beta-naphthoflavone. ( Randall, JL; Scott, WJ; York, RG, 1985) |
| "In a previous experiment, fetopathic effects of caffeine were significantly reduced by pretreatment with propranolol at dosage levels of 2." | 1.26 | Mitigation of caffeine-induced fetopathy in mice by pretreatment with beta-adrenergic blocking agents. ( Fujii, T, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 88 (70.40) | 18.7374 |
| 1990's | 19 (15.20) | 18.2507 |
| 2000's | 10 (8.00) | 29.6817 |
| 2010's | 6 (4.80) | 24.3611 |
| 2020's | 2 (1.60) | 2.80 |
| Authors | Studies |
|---|---|
| Yue, Y | 1 |
| Li, W | 1 |
| Tang, J | 1 |
| Zeng, Y | 1 |
| Xiong, T | 1 |
| Qiu, X | 1 |
| Shi, J | 1 |
| Wang, H | 1 |
| Xia, B | 1 |
| Luo, L | 1 |
| Qu, Y | 1 |
| Mu, D | 1 |
| Félix, L | 1 |
| Lobato-Freitas, C | 1 |
| Monteiro, SM | 1 |
| Venâncio, C | 1 |
| Nikoui, V | 1 |
| Ostadhadi, S | 1 |
| Takzare, N | 1 |
| Nabavi, SM | 1 |
| Giorgi, M | 1 |
| Bakhtiarian, A | 1 |
| Nakata, H | 1 |
| Miyazaki, T | 1 |
| Iwasaki, T | 1 |
| Nakamura, A | 1 |
| Kidani, T | 1 |
| Sakayama, K | 1 |
| Masumoto, J | 1 |
| Miura, H | 1 |
| Sandeep, M | 1 |
| Alvin, JM | 1 |
| Kuczkowski, KM | 1 |
| Peck, JD | 1 |
| Leviton, A | 3 |
| Cowan, LD | 1 |
| Robinson, JF | 1 |
| van Beelen, VA | 1 |
| Verhoef, A | 1 |
| Renkens, MF | 1 |
| Luijten, M | 1 |
| van Herwijnen, MH | 1 |
| Westerman, A | 1 |
| Pennings, JL | 1 |
| Piersma, AH | 1 |
| Brent, RL | 1 |
| Christian, MS | 1 |
| Diener, RM | 1 |
| Cowan, L | 1 |
| Nawrot, P | 1 |
| Jordan, S | 1 |
| Eastwood, J | 1 |
| Rotstein, J | 1 |
| Hugenholtz, A | 1 |
| Feeley, M | 1 |
| WINBERG, J | 1 |
| FRASER, FC | 1 |
| KNOCHE, C | 1 |
| KOENIG, J | 1 |
| KUEHNE, P | 1 |
| Bech, BH | 1 |
| Olsen, J | 1 |
| Bruyere, HJ | 3 |
| Fallon, JF | 1 |
| Gilbert, EF | 3 |
| Kalter, H | 1 |
| Warkany, J | 1 |
| James, JE | 1 |
| Stirling, KP | 1 |
| Wells, SJ | 1 |
| Hill, LM | 1 |
| Kleinberg, F | 1 |
| Kusama, T | 2 |
| Yoshizawa, Y | 2 |
| Cordero, JF | 1 |
| Oakley, GP | 1 |
| Fujii, T | 8 |
| Nakatsuka, T | 2 |
| Hanada, S | 1 |
| Ritter, EJ | 2 |
| Scott, WJ | 5 |
| Wilson, JG | 1 |
| Mathinos, PR | 1 |
| Randall, JL | 4 |
| Tanaka, H | 3 |
| Nakazawa, K | 2 |
| Arima, M | 1 |
| Iwasaki, S | 1 |
| Kurppa, K | 1 |
| Holmberg, PC | 1 |
| Kuosma, E | 1 |
| Saxén, L | 1 |
| Todorov, S | 1 |
| Gilani, SH | 3 |
| Giovinazzo, JJ | 1 |
| Persaud, TV | 7 |
| Miller, SA | 1 |
| Harris, JE | 1 |
| Palm, PE | 2 |
| Arnold, EP | 2 |
| Nick, MS | 1 |
| Valentine, JR | 1 |
| Doerfler, TE | 1 |
| Nomura, T | 2 |
| Graham, JM | 1 |
| Marin-Padilla, M | 1 |
| Hoefnagel, D | 1 |
| Nigro, N | 1 |
| Skalko, RG | 2 |
| Kwasigroch, TE | 1 |
| Renwick, JH | 2 |
| Rosenberg, L | 1 |
| Mitchell, AA | 1 |
| Shapiro, S | 1 |
| Slone, D | 1 |
| Kelsey, FO | 1 |
| Lee, H | 1 |
| Nagele, RG | 1 |
| Pietrolungo, JF | 1 |
| Streissguth, AP | 1 |
| Barr, HM | 1 |
| Martin, DC | 1 |
| Nolen, GA | 1 |
| Dunlop, M | 1 |
| Court, JM | 1 |
| Oser, BL | 1 |
| Ford, RA | 1 |
| Elmazar, MM | 1 |
| McElhatton, PR | 2 |
| Sullivan, FM | 2 |
| Lechat, MF | 1 |
| Borlee, I | 1 |
| Bouckaert, A | 1 |
| Misson, C | 1 |
| Barkovich, AJ | 1 |
| Rowley, H | 1 |
| Bollen, A | 1 |
| Iwase, T | 1 |
| Arishima, K | 1 |
| Ohyama, N | 1 |
| Inazawa, K | 1 |
| Iwase, Y | 1 |
| Ikeda, Y | 1 |
| Shirai, M | 1 |
| Yamamoto, M | 1 |
| Somiya, H | 1 |
| Eguchi, Y | 1 |
| Reddy, RV | 1 |
| Reddy, CS | 1 |
| Frappier, BL | 1 |
| Brimer, GE | 1 |
| Fraipier, BL | 1 |
| Sakamoto, MK | 1 |
| Mima, S | 1 |
| Kihara, T | 1 |
| Matsuo, T | 1 |
| Yasuda, Y | 1 |
| Tanimura, T | 1 |
| Golding, J | 1 |
| Hinds, TS | 1 |
| West, WL | 1 |
| Knight, EM | 1 |
| Harland, BF | 1 |
| Erdoğan, D | 1 |
| Kadioğlu, D | 1 |
| Peker, T | 1 |
| Marret, S | 1 |
| Gressens, P | 1 |
| Van-Maele-Fabry, G | 1 |
| Picard, J | 1 |
| Evrard, P | 1 |
| Fort, DJ | 2 |
| Stover, EL | 2 |
| Bantle, JA | 2 |
| Rayburn, JR | 1 |
| Hull, MA | 1 |
| Finch, RA | 1 |
| Burton, DT | 1 |
| Turley, SD | 1 |
| Dawson, DA | 2 |
| Linder, G | 1 |
| Buchwalter, D | 1 |
| Dumont, JN | 1 |
| Kumsher-King, M | 1 |
| Gaudet-Hull, AM | 1 |
| Propst, TL | 1 |
| Faulkner, BC | 1 |
| Vollmuth, TA | 1 |
| Murray, FJ | 1 |
| Colomina, MT | 2 |
| Sanchez, DJ | 2 |
| Esparza, JL | 1 |
| Domingo, JL | 2 |
| Lutz, J | 1 |
| Beck, SL | 2 |
| Burdan, F | 2 |
| Albina, ML | 1 |
| Ishikawa, S | 1 |
| Cheung, MO | 1 |
| Hodach, RJ | 1 |
| Weathersbee, PS | 1 |
| Lodge, JR | 1 |
| Perrins, NM | 1 |
| Niles, AM | 1 |
| Rachwall, PC | 1 |
| Leyczek, JC | 1 |
| Teague, KW | 1 |
| Kensler, CJ | 2 |
| von Kreybig, T | 1 |
| Czok, G | 1 |
| Terada, M | 1 |
| Nishmura, H | 1 |
| Yielding, LW | 1 |
| Riley, TL | 1 |
| Yielding, KL | 1 |
| Dlugosz, L | 1 |
| Bracken, MB | 1 |
| Fadel, RA | 1 |
| Kurishita, A | 3 |
| Ihara, T | 2 |
| Gilbody, JS | 1 |
| Urbano, CM | 1 |
| Benowitz, NL | 1 |
| Cerrato, PL | 1 |
| Ross, CP | 2 |
| Muther, TF | 1 |
| Al-Hachim, GM | 1 |
| Hemminki, K | 1 |
| Vineis, P | 1 |
| Sugiura, N | 1 |
| Kai, M | 1 |
| Zhai, SD | 1 |
| Chen, MQ | 1 |
| Dong, LP | 1 |
| Jia, XR | 1 |
| Nash, J | 1 |
| Ritter, JM | 1 |
| Lancaster, JS | 1 |
| Coles, CD | 1 |
| Platzman, KA | 1 |
| Smith, IE | 1 |
| Falek, A | 1 |
| Matsuoka, R | 1 |
| Uno, H | 2 |
| Kerr, CS | 1 |
| Nadal-Ginard, B | 1 |
| Heller, J | 1 |
| Hughes, HE | 1 |
| Goldstein, DA | 1 |
| Clark, RL | 1 |
| Eschbach, K | 1 |
| Cusick, WA | 1 |
| Heyse, JF | 1 |
| Pollard, I | 1 |
| Jabbour, H | 1 |
| Mehrabani, PA | 1 |
| Abbott, PJ | 1 |
| Smith, SE | 1 |
| Auerbach, BA | 1 |
| Słowikowska, MG | 1 |
| Lenarczyk, M | 1 |
| Gajewski, AK | 1 |
| Collins, TF | 1 |
| Welsh, JJ | 1 |
| Black, TN | 1 |
| Whitby, KE | 1 |
| O'Donnell, MW | 1 |
| Nishikawa, T | 1 |
| Gilbert, JE | 1 |
| York, RG | 2 |
| Bertrand, M | 1 |
| Girod, J | 1 |
| Rigaud, MF | 1 |
| Nishimura, H | 5 |
| Bartel, H | 2 |
| Mielczarek, J | 1 |
| Thayer, PS | 1 |
| Mulvihill, JJ | 1 |
| Kozaczenko, J | 1 |
| Sasaki, H | 1 |
| Snigórska, B | 1 |
| Mandelcorn, MS | 1 |
| Merin, S | 1 |
| Cardarelli, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial[NCT02832336] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2016-10-01 | Completed | ||
| Phase III Study Comparing Coristina® D to Resfenol® in the Symptomatic Treatment of Common Cold[NCT02735070] | Phase 3 | 366 participants (Anticipated) | Interventional | 2016-09-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
25 reviews available for caffeine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Maternal intake of caffeinated products and birth defects: a systematic review and meta-analysis of observational studies.
Topics: Abnormalities, Drug-Induced; Caffeine; Congenital Abnormalities; Female; Humans; Odds Ratio | 2021 |
Peripartum implications of caffeine intake in pregnancy: is there cause for concern?
Topics: Abnormalities, Drug-Induced; Adult; Animals; Beverages; Caffeine; Dose-Response Relationship, Drug; | 2009 |
Evaluation of the reproductive and developmental risks of caffeine.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Caffeine; Congenital Abnormalities; Fem | 2011 |
A review of the literature relating caffeine consumption by women to their risk of reproductive hazards.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Caffeine; Central Nervous System Stimulan | 2002 |
Effects of caffeine on human health.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Bone and Bones; Caffeine; Calcium; Cardiovascula | 2003 |
Congenital malformations (second of two parts).
Topics: Abnormalities, Drug-Induced; Air Pollutants, Occupational; Alcohol Drinking; Anesthetics; Anticoagul | 1983 |
Caffeine: a survey of some of the known and suspected deleterious effects of habitual use.
Topics: Abnormalities, Drug-Induced; Anxiety Disorders; Behavior Therapy; Caffeine; Coffee; Diagnosis, Diffe | 1983 |
Caffeine: implications of recent research for clinical practice.
Topics: Abnormalities, Drug-Induced; Affective Symptoms; Animals; Blood Pressure; Brain; Caffeine; Child; De | 1984 |
Effects of drugs and chemicals on the fetus and newborn (1).
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Behavior; Caffeine; Dicyclomine; Doxylamine; Drug | 1984 |
Drug exposure during pregnancy: some epidemiologic considerations.
Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations; | 1983 |
Reproduction and caffeine consumption--a literature review.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Administration, Oral; Animals; Caffeine; Chick E | 1995 |
The effect of caffeine on pregnancy outcome variables.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Dose-Response Relationship, Drug; Fema | 1996 |
[Teratogenic and embryotoxic effects of caffeine: facts and hypotheses].
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Humans; Maternal-Fetal Exchange; Pregnancy; | 2000 |
[Teratology, 40 years after the thalidomide tragedy].
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Abortion, Spontaneous; Animals; Caffe | 2001 |
Reproductive effects of caffeine: a review and theoretical analysis.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Caffeine; Female; Humans; Infertility; | 1992 |
Effects of maternal drug addiction on the fetus.
Topics: Abnormalities, Drug-Induced; Alcoholism; Amphetamines; Benzodiazepines; Caffeine; Cocaine; Female; F | 1991 |
Clinical pharmacology of caffeine.
Topics: Abnormalities, Drug-Induced; Caffeine; Cardiovascular Diseases; Humans; Mental Disorders; Risk Facto | 1990 |
Teratogenicity of caffeine; a review.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Coffee; Female; Humans; Infant, Newborn; Pregnancy; | 1989 |
Extrapolation of the evidence on teratogenicity of chemicals between humans and experimental animals: chemicals other than drugs.
Topics: Abnormalities, Drug-Induced; Anesthetics; Animals; Caffeine; Cannabinoids; Carbon Monoxide; Copper; | 1985 |
Reproductive and teratological risks of caffeine.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Humans; Pregnancy | 1988 |
Caffeine consumption and the risk of reproductive hazards.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Female; Humans; Infant, Low Birth Weig | 1988 |
What do we know about the risks of caffeine consumption in pregnancy?
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Female; Humans; Infant, Low Birth Weig | 1987 |
Caffeine: a toxicological overview.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Carbonated Beverages; Central Nervous System; Choles | 1986 |
[Brain dysfunction induced by maternal factors].
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Anticonvulsants; Brain; Brain Disease | 1985 |
[Effect of drugs, ingested by the mother during pregnancy, on the fetus].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Female; Humans; Meclizine; Pregnancy; | 1969 |
2 trials available for caffeine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Selected birth defects in relation to caffeine-containing beverages.
Topics: Abnormalities, Drug-Induced; Beverages; Caffeine; Cleft Lip; Cleft Palate; Clinical Trials as Topic; | 1982 |
Regulatory aspects of teratology: role of the Food and Drug Administration.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Clinical Trials as Topic; Congenital Abnormalities; | 1982 |
98 other studies available for caffeine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
24-Epibrassinolide modulates the neurodevelopmental outcomes of high caffeine exposure in zebrafish (Danio rerio) embryos.
Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Brassinosteroids; Caffeine; Embryo, Nonmamma | 2021 |
The role of clomipramine in potentiating the teratogenic effects of caffeine in pregnant rats: a histopathological study.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Clomipramine; Dose-Response Relationship, Drug; Drug | 2013 |
Development of tumor-specific caffeine-potentiated chemotherapy using a novel drug delivery system with Span 80 nano-vesicles.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Benzoates; Bone | 2015 |
Prenatal and developmental toxicity study of meclizine and caffeine combination in female albino Wistar rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Caffeine; Dose-Response Rel | 2014 |
A review of the epidemiologic evidence concerning the reproductive health effects of caffeine consumption: a 2000-2009 update.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Central Nervous System Stimulants; Fem | 2010 |
Embryotoxicant-specific transcriptomic responses in rat postimplantation whole-embryo culture.
Topics: Abnormalities, Drug-Induced; Acetates; Animals; Caffeine; Embryo Culture Techniques; Embryo Implanta | 2010 |
Risks for birth defects or low birth weight: air pollution...medications...and caffeine.
Topics: Abnormalities, Drug-Induced; Air Pollutants; Caffeine; Central Nervous System Stimulants; Congenital | 2002 |
[ANALYSIS OF THE POSSIBLE RELATION OF FETAL DAMAGE AND DRUGS. V. PRELIMINARY STUDY ON THE INFLUENCE OF 4 ANTIEMETICS ON FETAL DEVELOPMENT].
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Abortion, Spontaneous; Antiemetics; Birth Weight; Ca | 1964 |
EXPERIMENTAL TERATOGENESIS IN RELATION TO CONGENITAL MALFORMATIONS IN MAN.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Caffeine; Cortisone; Insulin; Lagomorph | 1964 |
[ON THE PRENATAL TOXICITY OF DIPHENYLPYRALINE 8-CHLOROTHEOPHYLLINATE WITH REFERENCE TO EXPERIENCES WITH THALIDOMIDE AND CAFFEINE].
Topics: Abnormalities, Drug-Induced; Anti-Allergic Agents; Caffeine; Fetal Death; Histamine H1 Antagonists; | 1964 |
[THE PROCEDURES FOR THE TESTING OF TERATOGENIC EFFECTS TAKE SHAPE].
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Haplorhini; Humans; Pregnancy; Sodium Chlori | 1965 |
[Pregnancy and caffeine].
Topics: Abnormalities, Drug-Induced; Caffeine; Central Nervous System Stimulants; Coffee; Embryonic and Feta | 2003 |
Does caffeine in pregnancy cause birth defects?
Topics: Abnormalities, Drug-Induced; Caffeine; Central Nervous System Stimulants; Female; Humans; Pregnancy | 2006 |
External malformations in chick embryos following concomitant administration of methylxanthines and beta-adrenomimetic agents: 1. Gross pathologic features.
Topics: Abnormalities, Drug-Induced; Adrenergic beta-Agonists; Animals; Caffeine; Chick Embryo; Dose-Respons | 1983 |
The synergistic effects of radiation and caffeine on embryonic development in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Caffeine; Embryonic and Feta | 1984 |
Potentiating effects of caffeine on teratogenicity of alkylating agents in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Alkylating Agents; Animals; Antibioti | 1983 |
Potentiating effects of methylxanthines on teratogenicity of mitomycin C in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antibiotics, Antineoplastic; Caffeine; Drug Synergism; Female; | 1983 |
Potentiative interactions between caffeine and various teratogenic agents.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Caffeine; Cycloheximide; Dactinomycin; Dose-Res | 1982 |
Caffeine and its dimethylxanthines and fetal cerebral development in rat.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Caffeine; Female; Fetus; Maternal-Fetal Exchange; Pregn | 1984 |
Coffee consumption during pregnancy and selected congenital malformations: a nationwide case-control study.
Topics: Abnormalities, Drug-Induced; Caffeine; Coffee; Female; Finland; Humans; Pilot Projects; Pregnancy; R | 1983 |
[Relationship between the placental-fetal index (PFI) and the toxic and teratogenic effect in the fetuses of mothers treated with sedalgin during pregnancy].
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Caffeine; Codeine; Drug Combinations; Female; Fetus; | 1983 |
Caffeine-induced limb malformations: description of malformations and quantitation of placental transfer.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Dose-Response Relationship, Drug; Female; Limb Defor | 1983 |
Embryopathic effects of caffeine in the chick.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chick Embryo; Hemorrhage; Intestines; Microphthalmos | 1983 |
Drugs in the food supply.
Topics: Abnormalities, Drug-Induced; Animals; Behavior; Caffeine; Female; Food Additives; Food Supply; Human | 1983 |
Two-year toxicity/carcinogenicity study of fresh-brewed coffee in rats initially exposed in utero.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Caffeine; Calcium; Carcinogens; F | 1984 |
Caffeine labeling. Council on Scientific Affairs. American Medical Association.
Topics: Abnormalities, Drug-Induced; Behavior; Cacao; Caffeine; Carbonated Beverages; Coffee; Female; Fibroc | 1984 |
Comparative inhibiting effects of methylxanthines on urethan-induced tumors, malformations, and presumed somatic mutations in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Caffeine; DNA Repair; Lung Neoplasms; M | 1983 |
Jejunal atresia associated with Cafergot ingestion during pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Caffeine; Drug Combinations; Ergotamine; Female; Humans; Infant, | 1983 |
[Do congenital malformations caused by caffeine exist?].
Topics: Abnormalities, Drug-Induced; Caffeine; Humans; Infant, Newborn | 1983 |
The interaction of chemicals during pregnancy: an update.
Topics: Abnormalities, Drug-Induced; Animals; Bromodeoxyuridine; Caffeine; Drug Interactions; Female; Fetus; | 1983 |
Food and malformation.
Topics: Abnormalities, Drug-Induced; Caffeine; Congenital Abnormalities; Female; Fetal Alcohol Spectrum Diso | 1982 |
Toxic and teratologic effects of caffeine on explanted early chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Caffeine; Chick Embryo; Culture Techniques; Dose-Respon | 1982 |
Offspring effects and pregnancy complications related to self-reported maternal alcohol use.
Topics: Abnormalities, Drug-Induced; Alcohol Drinking; Apgar Score; Caffeine; Female; Fetus; Heart Rate; Hum | 1982 |
The effect of brewed and instant coffee on reproduction and teratogenesis in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Caffeine; Coffee; Female; Fetal D | 1981 |
Effects of maternal caffeine ingestion on neonatal growth in rats.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Birth Weight; Body Weight; Caffeine; Female; | 1981 |
Third international caffeine workshop.
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Bone Development; Caffeine; Dose-Response Relatio | 1981 |
Caffeine: an update.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Behavior; Caffeine; Child; Child, Preschool | 1981 |
Acute studies to investigate the mechanism of action of caffeine as a teratogen in mice.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex; Amniotic Fluid; Animals; Caffeine; Cleft Palate; Cortic | 1981 |
Caffeine study.
Topics: Abnormalities, Drug-Induced; Caffeine; Female; Humans; Infant, Newborn; Pregnancy; Teratogens | 1980 |
Correlation of prenatal events with the development of polymicrogyria.
Topics: Abnormalities, Drug-Induced; Brain; Caffeine; Cerebral Cortex; Child; Child, Preschool; Ergotamine; | 1995 |
In vitro study of teratogenic effects of caffeine on cultured rat embryos and embryonic cells.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cell Differentiation; Cell Division; Cells, Cultured | 1994 |
Interaction of dimethylsulfoxide and arachidonic acid with the teratogenic effects of caffeine in mice.
Topics: Abnormalities, Drug-Induced; Animals; Arachidonic Acid; Caffeine; Cleft Palate; Corticosterone; Dime | 1994 |
Developmental toxicity of caffeine in the larvae of Xenopus laevis.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Dose-Response Relationship, Drug; Embryo, Nonmammali | 1993 |
Demonstration of congenital anomalies in the joints of the forelimbs and hindlimbs caused by several pharmacological agents.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agen | 1996 |
Caffeine-induced disturbances of early neurogenesis in whole mouse embryo cultures.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Embryo, Mammalian; Embryonic and Fetal Development; | 1997 |
Phase III interlaboratory study of FETAX, Part 2: interlaboratory validation of an exogenous metabolic activation system for frog embryo teratogenesis assay--Xenopus (FETAX).
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Caffeine; Cyclophosphamide; Lethal Dose 50; | 1998 |
Evaluation of the developmental toxicity of caffeine and caffeine metabolites using the frog embryo teratogenesis assay--Xenopus (FETAX).
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Caffeine; Central Nervous System Stimulants | 1998 |
Prenatal effects of caffeine and restraint stress in mice.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Congenital Abnormalities; Eating; Embryonic and Feta | 1999 |
Caffeine decreases the occurrence of cadmium-induced forelimb ectrodactyly in C57BL/6J mice.
Topics: Abnormalities, Drug-Induced; Animals; Cadmium; Caffeine; Central Nervous System Stimulants; Crosses, | 2000 |
Interactions in developmental toxicology: combined action of restraint stress, caffeine, and aspirin in pregnant mice.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Caffeine; Embryonic and Fetal Development; Female; Ma | 2001 |
The effects of methylxanthines on catecholamine-stimulated and normal chick embryos.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Abnormalities, Drug-Induced; Animals; Aortic Aneurysm; Aortic A | 1977 |
Similarity of the mechanism of chemical carcinogen-initiated teratogenesis and carcinogenesis in mice.
Topics: 4-Nitroquinoline-1-oxide; Abnormalities, Drug-Induced; Animals; Caffeine; Carcinogens; Congenital Ab | 1977 |
Alcohol, caffeine, and nicotine as factors in pregnancy.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Alcohol Drinking; Animals; Birth Weight; Caffe | 1979 |
The effect of 5-bromodeoxyuridine on mouse limb development: a scanning electron microscope study.
Topics: Abnormalities, Drug-Induced; Animals; Bromodeoxyuridine; Caffeine; Extremities; Female; Limb Deformi | 1977 |
Evaluation of the teratogenic potential of fresh-brewed coffee and caffeine in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Body Weight; Caffeine; Coffee; Cricetinae; Female; Le | 1978 |
[Teratogenic and mutagenic studies with caffeine in the animal experiment].
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Benzoates; Caffeine; Female; Lethal Dos | 1976 |
Mitigation of caffeine-induced fetopathy in mice by pretreatment with beta-adrenergic blocking agents.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fetus; Mice; Mice, Inbred ICR; Pregnancy; Pr | 1976 |
Mitigation of caffeine-induced teratogenicity in mice by prior chronic caffeine ingestion.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fetal Death; Gestational Age; Mice; Mice, In | 1975 |
Preliminary study of caffeine and chloroquine enhancement of x-ray induced birth defects.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chloroquine; Drug Synergism; Female; Male; Mice; Mic | 1976 |
Effects of alcohol and caffeine on cultured whole rat embryos.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Embryo, Mammalian; Embryonic and Fetal Development; | 1992 |
Hyperploid cells in the limb buds of rats and 5-azacytidine-induced digital deformities.
Topics: Abnormalities, Drug-Induced; Animals; Azacitidine; Caffeine; Female; Hindlimb; Humans; Male; Polyplo | 1991 |
Potentiating effect of caffeine on the teratogenicity of acetazolamide in C57BL/6J mice.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Caffeine; Drug Synergism; Female; Humans; Male; | 1991 |
Caffeine: how much is too much?
Topics: Abnormalities, Drug-Induced; Adult; Caffeine; Cardiovascular System; Female; Humans; Infant, Newborn | 1990 |
Craniofacial and limb development in early rat embryos following in utero exposure to ethanol and caffeine.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Ethanol; Extremities; Facial Bones; Female; Limb Def | 1990 |
Inhibitory effect of caffeine on 5-azacytidine-induced digital malformations in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Azacitidine; Caffeine; Dose-Response Relationship, Drug; Femal | 1987 |
Caffeine and reduction of fetal ossification in the rat: fact or artifact?
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Dose-Response Relationship, Drug; Female; Gestationa | 1988 |
Histological study of cell death in digital malformations induced by 5-azacytidine: suppressive effect of caffeine.
Topics: Abnormalities, Drug-Induced; Animals; Azacitidine; Caffeine; Cell Survival; Dose-Response Relationsh | 1989 |
Neural tube defects in early rat embryos following maternal treatment with ethanol and caffeine.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Central Nervous System; Ethanol; Female; Neural Tube | 1989 |
Caffeine cubes.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Humans; Mice; Pregnancy | 1988 |
Combined effects of radiation and caffeine on embryonic development in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Body Weight; Caffeine; Embry | 1989 |
[Antagonistic effects of ascorbic acid on caffeine-induced embryotoxic and teratogenic activities in rats].
Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Caffeine; Female; Pregnancy; Rats; Rats, Inbred | 1986 |
Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Caproates; Diethylhexyl Phthalate; Drug Synergism; F | 1987 |
Contributions of maternal alcohol, caffeine, and cigarette use to neonatal status.
Topics: Abnormalities, Drug-Induced; Caffeine; Ethanol; Female; Humans; Infant, Newborn; Pregnancy; Smoking | 1987 |
Caffeine induces cardiac and other malformations in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Caffeine; Female; Heart Defects, Congenital; L | 1987 |
Birth defects following maternal exposure to ergotamine, beta blockers, and caffeine.
Topics: Abnormalities, Drug-Induced; Caffeine; Ergotamine; Female; Humans; Infant, Newborn; Migraine Disorde | 1988 |
Interactions between caffeine and adenosine agonists in producing embryo resorptions and malformations in mice.
Topics: 2-Chloroadenosine; Abnormalities, Drug-Induced; Adenosine; Animals; Body Weight; Caffeine; Drug Admi | 1987 |
Effects of caffeine administered during pregnancy on fetal development and subsequent function in the adult rat: prolonged effects on a second generation.
Topics: 3-Hydroxysteroid Dehydrogenases; Abnormalities, Drug-Induced; Animals; Birth Weight; Caffeine; Embry | 1987 |
Effects of administering caffeine to pregnant rats either as a single daily dose or as divided doses four times a day.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Caffeine; Dose-Response Relationship, Drug; Femal | 1987 |
Teratogenic effects in mice exposed to single dose of X-rays and prolonged administration of caffeine during pregnancy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Caffeine; Female; Maternal-F | 1986 |
Coadministration of methylxanthines and inhibitor compounds potentiates teratogenicity in Xenopus embryos.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cycloheximide; Cytarabine; Drug Synergism; Embryo, N | 1987 |
Potential reversibility of skeletal effects in rats exposed in utero to caffeine.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Body Weight; Bone and Bones; Caffeine; Drink | 1987 |
Chick embryonic development following exposure to caffeine and nicotine.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chick Embryo; Dose-Response Relationship, Drug; Gest | 1986 |
Pulmonary stenosis with ventricular septal defect, common aorticopulmonary trunk, and dextroposition of the aorta: morphologic and qualitative physiologic effects in caffeine-treated chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chick Embryo; Cineradiography; Heart; Heart Defects, | 1986 |
Teratogenicity of paraxanthine (1,7-dimethylxanthine) in C57BL/6J mice.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cleft Palate; Dose-Response Relationship, Drug; Fema | 1986 |
Caffeine.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fibrocystic Breast Disease; Half-Life; Heart | 1985 |
Reduction of caffeine teratogenicity in mice by inducing maternal drug metabolism with beta-naphthoflavone.
Topics: Abnormalities, Drug-Induced; Animals; Benzoflavones; beta-Naphthoflavone; Caffeine; Cytochrome P-450 | 1985 |
Embryopathic effects of ethanol and caffeine in the chick.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chick Embryo; Drug Synergism; Ethanol; Mortality | 1985 |
[Ectrodactyly caused by caffeine in rodents. Role of specific and genetic factors].
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fingers; Mice; Rabbits; Rats; Rodentia | 1970 |
Reduction in frequency of fetopathic effects of caffeine in mice by pretreatment with propranolol.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Catecholamines; Female; Fetus; Humans; Maternal-Feta | 1974 |
Proceedings: Prevention of embryopathic effects of caffeine in mice by pretreatment with propranolol.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Embryo, Mammalian; Female; Humans; Mice; Pregnancy; | 1974 |
[Teratogenic effect of caffeine on the development of extremities in mice].
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Gestational Age; Limb Deformities, Congenita | 1973 |
Exposure of four generations of mice to caffeine in drinking water.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Breeding; Caffeine; Dose-Response Relationship, D | 1973 |
Caffeine as teratogen and mutagen.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chromosome Aberrations; Female; Fetal Death; Fetus; | 1973 |
Adverse effects of prolonged administration of caffeine on rat fetus.
Topics: Abnormalities, Drug-Induced; Animals; Blood Cell Count; Body Weight; Caffeine; Diet; Edema; Esophagu | 1972 |
Teratogenicity of caffeine in mice related to its mode of administration.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cleft Palate; Clubfoot; Dyspnea; Fingers; Gestationa | 1969 |
[Studies on the teratogenic influence of caffeine on the fetuses of white mice].
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Caffeine; Female; Limb Deformities, Congenit | 1970 |
Teratogenic actions of some methylated xanthines in mice.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fetus; Injections, Intraperitoneal; Male; Mi | 1969 |
Goldenhar's syndrome and phocomelia. Case report and etiologic considerations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Threatened; Aspirin; Caffeine; Child | 1971 |