cadmium has been researched along with Acute Liver Injury, Drug-Induced in 138 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (18.12) | 18.7374 |
| 1990's | 23 (16.67) | 18.2507 |
| 2000's | 21 (15.22) | 29.6817 |
| 2010's | 38 (27.54) | 24.3611 |
| 2020's | 31 (22.46) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L; Chen, X; Wang, X; Wu, J; Wu, Y; Xu, C; Xu, H; Yang, L | 1 |
| Bai, Z; Chang, X; Li, J; Li, X; Qi, K; Ren, C; Ren, L; Xie, Y; Yan, J; Zhang, H; Zhu, J | 1 |
| Bian, J; Liu, Z; Sun, J; Wang, T; Yu, F; Zou, H | 1 |
| Kumar, A; Kumar, P | 1 |
| Huang, X; Shan, D; Xu, Q; Zhao, M; Zhu, X | 1 |
| Hu, R; Li, G; Li, Y; Pi, S; Wang, C; Wang, X; Wei, Z; Yang, F; Zhang, C | 1 |
| Cao, W; Cao, X; Gao, W; Huang, X; Liu, X; Liu, Z; Tang, B | 1 |
| Ashraf, A; Ehsan, N; Ijaz, MU; Neamul Kabir Zihad, SM; Noor, KK; Simal-Gandara, J; Tahir, A; Uddin, SJ; Yeni, DK | 1 |
| Cui, S; Ma, K; Qiu, G; Zheng, J; Zhou, Y | 1 |
| Liu, Y; Si, B; Tong, H; Wang, T; Wang, X; Wu, Y; Xu, A; Zheng, X; Zhou, Y | 1 |
| Deng, Q; Fang, Z; Huang, L; Li, Y; Sun, L; Wang, J; Wang, X | 1 |
| Duan, WX; Duan, Y; Li, HJ; Li, YY; Liu, C; Liu, YS; Sun, YP; Xu, SC; Yu, Q; Zhang, T | 1 |
| Ali, W; Bian, J; Duan, Y; Gu, J; Liu, Z; Ma, Y; Sun, J; Wang, T; Yuan, Y; Zhao, Y; Zou, H | 1 |
| Choi, JS; Gali, S; Han, JH; Kim, HS; Kim, JS; Kundu, A; Kyung, SY; Lee, E; Sharma, S; Shin, JK | 1 |
| Li, JL; Li, N; Li, XN; Saleem, MAU; Yi, BJ | 1 |
| Chen, F; Chen, M; Deng, P; Hao, R; Li, J; Luo, Y; Pi, H; Tian, L; Wang, H; Xiao, H; Xie, J; Yu, Z; Yue, Y; Zhou, Z | 1 |
| Amri, M; Bahri, S; Bouraoui, S; Kaddour, H; Karoui, D; Mokni, M | 1 |
| Chen, C; Guo, W; He, Y; Hu, S; Li, L; Li, S; Liu, C; Lu, Z; Tumen, B; Wang, Y; Xu, K; Zhu, Y | 1 |
| Bandyopadhyay, D; Bhattacharjee, B; Chattopadhyay, A; Pal, PK | 1 |
| Ahangar, N; Amiri, FT; Arab-Nozari, M; Mohammadi, E; Shaki, F; Shokrzadeh, M | 1 |
| Rana, K; Rana, SVS; Verma, Y | 1 |
| Ge, J; Li, JL; Lv, M; Talukder, M; Zhang, C; Zhang, Q | 1 |
| Bandegi, AR; Dehdashti, A; Ghanbari, A; Goodarzi, Z; Karami, E; Yousefi, S | 1 |
| Kaur, G; Kumar, M; Kushwah, AS; Shivanandappa, TB | 1 |
| Moradkhani, S; Nili-Ahmadabadi, A; Rezaei-Dehghanzadeh, T | 1 |
| Ahangar, N; Amiri, FT; Arab-Nozari, M; Lorigooini, Z; Mohammadi, E; Shaki, F; Shokrzadeh, M | 1 |
| Chakraborty, R; Famurewa, AC; George, A; Koti, R; Madhyastha, H; Myakala, H; Renu, K; Valsala Gopalakrishnan, A; Vellingiri, B | 1 |
| Alrashood, ST; Dubey, A; Khan, HA; Kumar, A; Sharma, B; Siddiqi, NJ | 1 |
| Ba, Q; Li, J; Mu, W; Wang, H; Xu, Y | 1 |
| Li, S; Wang, W; Yan, B; Zhang, Q | 1 |
| Caglayan, C; Darendelioğlu, E; İzol, E; Kandemir, FM; Kandemir, Ö; Küçükler, S | 1 |
| Chen, J; Wan, XM; Wang, M; Zheng, C; Zhou, XL | 1 |
| Huang, Y; Luo, Y; Shao, M; Yu, Z; Zhang, L; Zhu, Y | 1 |
| Aburto-Luna, V; Aguilar-Alonso, P; Brambila, E; Diaz, A; Flores-Hernández, JÁ; Moroni-González, D; Sarmiento-Ortega, VE; Treviño, S | 1 |
| Athmouni, K; Ayadi, H; Belhaj, D; El Feki, A | 1 |
| Gluhcheva, Y; Ivanova, J; Kamenova, K; Stoykova, S; Vladov, I | 1 |
| El-Hussieny, M; Refaie, MMM; Zenhom, NM | 1 |
| Brzóska, MM; Mężyńska, M | 1 |
| Athmouni, K; Ayadi, H; Belhaj, D; El Feki, A; Gammoudi, S | 1 |
| Bandyopadhyay, D; Bhattacharjee, B; Chattopadhyay, A; Ghosh, AK; Mishra, S; Pal, PK | 1 |
| Fan, RF; Gong, ZG; Wang, JH; Wang, L; Wang, XY | 1 |
| Ali, S; Andleeb, S; Khan, MA; Khan, R; Mumtaz, S; Shakir, HA; Ulhaq, M | 1 |
| Brzóska, MM; Galicka, A; Mężyńska, M; Rogalska, J | 1 |
| Ejezie, FE; Famurewa, AC; Folawiyo, AM; Iyare, EE; Maduagwuna, EK; Ugwu-Ejezie, CS | 1 |
| Oleńska, E; Salińska, A; Włostowski, T | 1 |
| Chung, M; Cosgrove, D; Firoozmand, A; Gurakar, A; Herman, JM; Hyder, O; Koteish, A; Li, Z; Pawlik, TM | 1 |
| Chen, FX; Gong, P; Jin, S; Ma, YM; Wang, J; Wang, L | 1 |
| Arafa, MH; Atteia, HH; Mohammad, NS | 1 |
| Aoyama, H; Camargo, CA; Camargo, Cde A; Cruz, B; da Silva Diamante, MA; de Souza Predes, F; Dolder, H; Foglio, MA; Gomes Marcondes, MC; Miranda, SC | 1 |
| Amamou, F; Chabane-Sari, D; Didi, A; Meziane, RK; Nemmiche, S; Yazit, SM | 1 |
| Horiguchi, H; Oguma, E | 1 |
| Cao, Z; Chen, M; Du, C; Fang, Y; He, M; Li, Y; Lu, Y; Ma, Q; Pei, L; Ran, H; Tan, D; Yu, J; Yu, Z; Zhang, L; Zhou, C; Zhou, Z | 1 |
| Bolkent, S; Koyuturk, M; Tunali, S; Yanardag, R | 1 |
| Chung, KW; Han, JG; Lim, BL; Om, AS; Park, HS; Shim, JY; Shin, HS | 1 |
| Carreau, S; El Feki, A; Hamden, K; Marki, FA; Masmoudi, H | 1 |
| Prabu, SM; Renugadevi, J | 1 |
| Al-Melhim, WN; Fouad, AA; Qureshi, HA; Yacoubi, MT | 1 |
| Dai, W; Kim, SG; Li, G; Xu, Z | 1 |
| Pari, L; Shagirtha, K | 1 |
| Chang, H; Chang, LW; Chang, WH; Lin, CH; Lin, P; Tsai, MH; Wang, CJ; Yang, CS; Yang, MH | 1 |
| Li, CH; Li, XD; Liu, XJ; Luo, Z; Xiong, BX; Zhao, YH | 1 |
| Brzóska, MM; Pilat-Marcinkiewicz, B; Rogalska, J | 1 |
| Prabu, SM; Renugadevi, J; Shagirtha, K | 1 |
| Abdelhamid, K; Fatima, H; Jihen, el H; Mohamed Tahar, S; Sonia, S | 1 |
| Shati, AA | 1 |
| Awadalla, EA; Bekheet, SH; Hassan, MK; Salman, MM | 1 |
| Adeniran, OY; Lawal, AF; Obi, F; Olalekan Lawal, A; Ologundudu, A; Omonkhua, A | 1 |
| Demonakou, MD; Kourentzi, KT; Kyriakou, LG; Mykoniatis, MG; Panoutsopoulos, GI; Tzirogiannis, KN | 1 |
| Huang, HJ; Jin, F; Jin, H; Jin, JX; Liu, J; Tao, TT; Xu, J | 1 |
| Das, J; Roy, A; Sil, PC | 1 |
| Buha, A; Bulat, Z; Dukić-Ćosić, D; Matović, V | 1 |
| Cho, SH; Hong, YC; Kang, MY; Lim, YH; Seo, JC | 1 |
| Amako, K; Min, KS; Takano, M; Tanaka, K; Ueda, H | 1 |
| Alexandropoulou, KN; Basayannis, AC; Demonakou, MD; Hereti, RI; Mykoniatis, MG; Panoutsopoulos, GI; Tzirogiannis, KN | 1 |
| EYBL, V; MERTL, F; SYKORA, J | 1 |
| Demonakou, MD; Hereti, RI; Kondyli, VG; Kourentzi, KT; Mykoniatis, MG; Panoutsopoulos, GI; Papadimas, GK; Tzirogiannis, KN | 1 |
| Liu, J; Qu, W; Saavedra, JE; Waalkes, MP | 1 |
| Imamura, Y; Shimada, A; Shimada, H; Takamure, Y; Waalkes, MP; Yasutake, A | 1 |
| Balagangatharathilagar, M; Kumar, P; Nandi, D; Naresh, R; Patra, RC; Swarup, D; Varshney, VP | 1 |
| Antonio, MT; Corredor, L; Massó, EL | 1 |
| Borges, LP; Brandão, R; Godoi, B; Nogueira, CW; Zeni, G | 1 |
| Hirashima, T; Imamura, Y; Kitano, T; Shimada, H; Takamure, Y; Waalkes, MP; Yasutake, A | 1 |
| Egido, J; López-Novoa, JM; Morales, AI; Pérez-Barriocanal, F; Sánchez-González, PD; Vicente-Sánchez, C | 1 |
| Chapatwala, KD; Hobson, M; Rajanna, B; Reese, J; Sample, E | 1 |
| Adamska-Dyniewska, H; Trojanowska, B | 1 |
| Edds, GT; Osuna, O | 1 |
| Acosta, D; Bruckner, JV; Santone, KS | 1 |
| Ashquin, M; Behari, JR; Flora, SJ; Tandon, SK | 1 |
| Dudley, RE; Klaassen, C; Svoboda, DJ | 1 |
| Cain, K; Griffiths, B | 1 |
| Badger, DA; Baines, A; Hooser, SB; Sauer, JM; Sipes, IG | 1 |
| Klaassen, CD; Liu, J; Liu, Y | 1 |
| Choudhuri, S; Klaassen, CD; Kreppel, H; Liu, J; Liu, Y | 1 |
| Hiratsuka, H; Katsuta, O; Marumo, F; Matsumoto, J; Tsuchitani, M; Umemura, T | 1 |
| Rana, SV; Singh, R; Verma, S | 1 |
| Hochadel, JF; Waalkes, MP | 1 |
| Funakoshi, T; Kojima, S; Shimada, H; Ueda, K | 1 |
| Bare, RM; Hochadel, JF; Shimada, H; Waalkes, MP | 1 |
| Baines, AT; Hooser, SB; Kuester, RK; Sauer, JM; Sipes, IG; Waalkes, MP | 1 |
| Lai, YR; Sugawara, N | 1 |
| Conrad, CC; Grabowski, DT; Hanes, MA; Richardson, A; Walter, CA | 1 |
| Habeebu, SS; Klaassen, CD; Liu, J; Liu, Y | 2 |
| Deters, M; Siegers, CP; Strubelt, O | 1 |
| Noda, T; Shimizu, M; Yamano, T | 1 |
| Ando, M; Hayashi, Y; Mitsumori, K; Nakagawa, J; Onodera, H; Sato, S; Shibutani, M | 1 |
| Anver, MR; Diwan, BA; Waalkes, MP | 1 |
| Kosanke, SD; Rikans, LE; Yamano, T | 1 |
| DeCicco, LA; Rikans, LE; Yamano, T | 1 |
| Fukushima, M; Harada, A; Homma, Y; Horiguchi, H; Kayama, F; Matsushima, K; Oguma, E; Sato, M | 1 |
| Krasowska, A; Laszkiewicz-Tiszczenko, B; Włostowski, T | 1 |
| Fukushima, M; Horiguchi, H; Kayama, F; Oguma, E; Sato, M | 1 |
| Cherrington, NJ; Hartley, DP; Klaassen, CD; Takiguchi, M; Waalkes, MP | 1 |
| Bucio, L; Damián-Matsumura, P; del Carmen, EM; Gutiérrez-Ruiz, MC; Hernández, E; Souza, V; Zaga, V | 1 |
| Fujii, M; Kim, H; Min, KS; Onosaka, S; Tetsuchikawahara, N | 1 |
| Merali, Z; Singhal, RL | 1 |
| Engström, B; Nordberg, GF | 1 |
| Malchow, H; Schmeisser, W | 1 |
| Dessì, A; Dore, M; Montaldo, C; Sanna, A; Vargiolu, S | 1 |
| Colucci, AV; Krasno, J; Winge, D | 1 |
| Cook, JA; Coover, JA; di Luzio, NR; Hoffmann, EO | 1 |
| Morita, S; Shimizu, M | 1 |
| Kershaw, WC; Klaassen, CD; Liu, J; Liu, YP | 1 |
| Bauman, JW; Klaassen, CD; Liu, J; McKim, JM | 1 |
| Deliconstantinos, G; Fasitsas, C; Loizidou, M; Margeli, A; Theocharis, S | 1 |
| Klaassen, CD; Liu, J; Madhu, C; Maziasz, TJ | 1 |
| Bischoff, J; Böcker, R; Estler, CJ; Hopf, G; Werner, MG | 1 |
| Copius Peereboom-Stegeman, JH; Frederiks, WM; Morselt, AF; van Veen, HA | 1 |
| Anderson, ME; Meister, A; Singhal, RK | 1 |
| Basinger, MA; Craft, WD; Jones, MM; Sanders, MM; Walker, EM | 1 |
| Clarke, IS; Lui, EM | 1 |
| Atkins, LM; Gale, GR; Lamar, C; Smith, AB; Walker, EM | 1 |
| Dudley, RE; Gammal, LM; Klaassen, CD | 1 |
| Goyer, RA; Stowe, HD; Wilson, M | 1 |
| Browder, AA; Joselow, MM; Louria, DB | 1 |
| Webb, M | 1 |
| de Néchaud, B; Uriel, J | 1 |
7 review(s) available for cadmium and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) - induced hepatotoxicity - A review.
Topics: Arsenic; Cadmium; Chemical and Drug Induced Liver Injury; Chromium; Humans; Lead; Mercury; Metals, Heavy; Nickel | 2021 |
Review of polyphenol-rich products as potential protective and therapeutic factors against cadmium hepatotoxicity.
Topics: Animals; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Environmental Exposure; Humans; Models, Animal; Oxidative Stress; Plant Extracts; Protective Agents | 2019 |
Mechanism of the protective action of taurine in toxin and drug induced organ pathophysiology and diabetic complications: a review.
Topics: Animals; Antioxidants; Arsenic; Blood Pressure; Cadmium; Calcium; Chemical and Drug Induced Liver Injury; Cytokines; Cytoprotection; Diabetes Complications; Fluorides; Hazardous Substances; Heart Diseases; Humans; Kidney Diseases; Nervous System Diseases; Neurotransmitter Agents; Taurine; Water-Electrolyte Balance | 2012 |
The relationship between cadmium concentrations in liver biopsy material and in venous blood.
Topics: Acute Disease; Age Factors; Aged; Cadmium; Chemical and Drug Induced Liver Injury; Female; Hepatitis, Chronic; Humans; Liver; Liver Neoplasms; Male; Middle Aged | 1981 |
Alterations in chemically induced tissue injury related to all-trans-retinol pretreatment in rodents.
Topics: Animals; Cadmium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Ethanol; Liver; Liver Diseases; Mice; Rats; Vitamin A | 1995 |
[Occupational liver lesions].
Topics: Arsenic; Cadmium; Chemical and Drug Induced Liver Injury; Chromium; Fatty Liver; Humans; Liver Cirrhosis; Liver Neoplasms; Occupational Diseases; Paraquat; Time Factors; Vinyl Chloride | 1977 |
The human toxicity of certain trace elements.
Topics: Arsenic; Cadmium; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Cobalt; Copper; Gastrointestinal Diseases; Heart Diseases; Humans; Liver; Lung Diseases; Manganese Poisoning; Molybdenum; Nickel; Occupational Medicine; Selenium; Tellurium; Tin; Trace Elements; Vanadium; Zinc | 1972 |
131 other study(ies) available for cadmium and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Magnesium isoglycyrrhizinate prevents cadmium-induced activation of JNK and apoptotic hepatocyte death by reversing ROS-inactivated PP2A.
Topics: Animals; Apoptosis; Cadmium; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Environmental Pollutants; Glycyrrhizic Acid; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Liver; MAP Kinase Signaling System; Mice; Oxidative Stress; Protein Phosphatase 2; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes | 2021 |
Dual role of cadmium in rat liver: Inducing liver injury and inhibiting the progression of early liver cancer.
Topics: Animals; Body Weight; Cadmium; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Gene Expression Regulation; Hepatocytes; Liver; Liver Neoplasms; Male; Microtubule-Associated Proteins; Mitochondrial Precursor Protein Import Complex Proteins; Mitophagy; Organ Size; Protein Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequestosome-1 Protein; Ubiquitin-Protein Ligases | 2022 |
The role of DRP1- PINK1-Parkin-mediated mitophagy in early cadmium-induced liver damage.
Topics: Animals; Cadmium; Cell Line; Chemical and Drug Induced Liver Injury; Dynamins; Female; Hepatocytes; Liver; Mice; Mice, Inbred BALB C; Mitochondria; Mitochondrial Dynamics; Mitophagy; Protein Kinases; Signal Transduction; Superoxides; Ubiquitin-Protein Ligases | 2022 |
Unswerving modeling of hepatotoxicity of cadmium containing quantum dots using amalgamation of quasiSMILES, index of ideality of correlation, and consensus modeling.
Topics: Cadmium; Chemical and Drug Induced Liver Injury; Consensus; Humans; Quantitative Structure-Activity Relationship; Quantum Dots | 2021 |
Metabolomics in liver injury induced by dietary cadmium exposure and protective effect of calcium supplementation.
Topics: Animals; Cadmium; Calcium; Chemical and Drug Induced Liver Injury; Dietary Supplements; Female; Metabolomics; Protective Agents; Rats; Rats, Sprague-Dawley | 2022 |
Nrf2 axis and endoplasmic reticulum stress mediated autophagy activation is involved in molybdenum and cadmium co-induced hepatotoxicity in ducks.
Topics: Animals; Autophagy; Cadmium; Chemical and Drug Induced Liver Injury; Ducks; Endoplasmic Reticulum Stress; Liver; Molybdenum; NF-E2-Related Factor 2; Oxidative Stress | 2022 |
Hepatotoxicity-Related Oxidative Modifications of Thioredoxin 1/Peroxiredoxin 1 Induced by Different Cadmium-Based Quantum Dots.
Topics: Cadmium; Cadmium Compounds; Chemical and Drug Induced Liver Injury; Humans; Hydrogen Peroxide; Oxidation-Reduction; Oxidative Stress; Peroxiredoxins; Quantum Dots; Tellurium; Thioredoxins | 2022 |
Hepatoprotective role of vitexin against cadmium-induced liver damage in male rats: A biochemical, inflammatory, apoptotic and histopathological investigation.
Topics: Animals; Antioxidants; Apigenin; Cadmium; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Male; Oxidative Stress; Rats | 2022 |
Hepatoprotective Effects of Taurine Against Cadmium-Induced Liver Injury in Female Mice.
Topics: Animals; Antioxidants; Apoptosis; Body Weight; Cadmium; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Female; Humans; Liver; Mice; Oxidative Stress; Taurine | 2023 |
Zinc oxide/graphene oxide nanocomposites efficiently inhibited cadmium-induced hepatotoxicity via releasing Zn ions and up-regulating MRP1 expression.
Topics: Cadmium; Chemical and Drug Induced Liver Injury; Drug Resistance, Multiple; Graphite; Humans; Ions; Multidrug Resistance-Associated Proteins; Nanocomposites; Zinc; Zinc Oxide | 2022 |
Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.
Topics: Animals; Antioxidants; Apoptosis; Cadmium; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Liver; Mice; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt | 2023 |
MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium.
Topics: Animals; Cadmium; Calcium Channels; Chemical and Drug Induced Liver Injury; Dimerization; Mice; Mitochondrial Proteins; Mitophagy; Ubiquitination; Up-Regulation; Voltage-Dependent Anion Channel 1 | 2023 |
Taurine Alleviates Cadmium-Induced Hepatotoxicity by Regulating Autophagy Flux.
Topics: Animals; Autophagosomes; Autophagy; Cadmium; Cell Line; Chemical and Drug Induced Liver Injury; Lysosomes; Qb-SNARE Proteins; Qc-SNARE Proteins; Rats | 2023 |
Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Liver; Oxidative Stress; Rats; Rats, Sprague-Dawley; Silymarin; Superoxide Dismutase | 2023 |
Autophagy protects against Cd-induced cell damage in primary chicken hepatocytes via mitigation of oxidative stress and endoplasmic reticulum stress.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Cadmium; Chemical and Drug Induced Liver Injury; Chickens; Endoplasmic Reticulum Stress; Hepatocytes; Oxidative Stress; Reactive Oxygen Species | 2023 |
Transcriptomics integrated with metabolomics unravels the interweaving of inflammatory response and 1-stearoyl-2-arachidonoyl-sn-glycerol metabolic disorder in chronic cadmium exposure-induced hepatotoxicity.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; Liver; Metabolomics; Mice; Mice, Inbred C57BL; Transcriptome | 2023 |
Protective role of vitamin E against cadmium induced oxidative stress into the rat liver.
Topics: Animals; Antioxidants; Cadmium; Catalase; Chemical and Drug Induced Liver Injury; Cytoprotection; Hepatocytes; Lipid Peroxidation; Liver; Male; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Vitamin E | 2019 |
Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Models, Animal; NF-E2-Related Factor 2; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein | 2019 |
Oleic acid protects against cadmium induced cardiac and hepatic tissue injury in male Wistar rats: A mechanistic study.
Topics: Animals; Antioxidants; Biomarkers; Cadmium; Chemical and Drug Induced Liver Injury; Heart; Heart Injuries; Inflammation; Liver; Male; Myocardium; Oleic Acid; Oxidative Stress; Rats; Rats, Wistar | 2020 |
Co-exposure to non-toxic levels of cadmium and fluoride induces hepatotoxicity in rats via triggering mitochondrial oxidative damage, apoptosis, and NF-kB pathways.
Topics: Animals; Antioxidants; Apoptosis; Cadmium; Chemical and Drug Induced Liver Injury; Fluorides; Liver; Male; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Rats | 2020 |
Possible Mechanisms of Liver Injury Induced by Cadmium Sulfide Nanoparticles in Rat.
Topics: Animals; Cadmium; Cadmium Compounds; Chemical and Drug Induced Liver Injury; Hydrogen Peroxide; Lipid Peroxidation; Liver; Nanoparticles; Oxidative Stress; Rats; Rats, Wistar; Sulfides | 2021 |
Selenium prevent cadmium-induced hepatotoxicity through modulation of endoplasmic reticulum-resident selenoproteins and attenuation of endoplasmic reticulum stress.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Oxidative Stress; Selenium; Selenoproteins | 2020 |
Hepatoprotective effect of atorvastatin on Cadmium chloride induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Atorvastatin; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2020 |
Fumaric acid protect the cadmium-induced hepatotoxicity in rats: owing to its antioxidant, anti-inflammatory action and aid in recast the liver function.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Female; Fumarates; Liver; Male; Oxidative Stress; Rats; Rats, Wistar | 2020 |
Rosa persica hydroalcoholic extract improves cadmium-hepatotoxicity by modulating oxidative damage and tumor necrosis factor-alpha status.
Topics: Animals; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Lipid Peroxidation; Liver; Mice; Oxidative Stress; Plant Extracts; Rosa; Tumor Necrosis Factor-alpha | 2020 |
Ginkgo biloba attenuated hepatotoxicity induced by combined exposure to cadmium and fluoride via modulating the redox imbalance, Bax/Bcl-2 and NF-kB signaling pathways in male rats.
Topics: Animals; bcl-2-Associated X Protein; Cadmium; Chemical and Drug Induced Liver Injury; Fluorides; Ginkgo biloba; Male; NF-kappa B; Oxidation-Reduction; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction | 2020 |
Protective effect of eugenol on hepatic inflammation and oxidative stress induced by cadmium in male rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cadmium; Catalase; Chemical and Drug Induced Liver Injury; Eugenol; Glutathione; Glutathione Transferase; Lipid Peroxidation; Liver; Male; Nitric Oxide; Oxidative Stress; Rats, Wistar; Superoxide Dismutase | 2021 |
Chronic cadmium exposure at environmental-relevant level accelerates the development of hepatotoxicity to hepatocarcinogenesis.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; Endothelial Cells; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male; Mice | 2021 |
Co-exposures of TiO
Topics: Acute Disease; Animals; Cadmium; Chemical and Drug Induced Liver Injury; Concanavalin A; Drug Interactions; Female; Hepatitis; Liver; Mice, Inbred BALB C; Nanoparticles; Oxidative Stress; Titanium | 2021 |
Modulatory effects of carvacrol against cadmium-induced hepatotoxicity and nephrotoxicity by molecular targeting regulation.
Topics: Animals; Apoptosis; Biomarkers; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Cymenes; Inflammation; Kidney; Lipid Peroxidation; Liver; Male; Molecular Targeted Therapy; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Rats, Wistar; Renal Insufficiency | 2021 |
Puerarin attenuates cadmium-induced hepatic lipid metabolism disorder by inhibiting oxidative stress and inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Environmental Pollutants; Inflammation; Isoflavones; Lipid Metabolism; Lipid Peroxidation; Liver; Mice, Inbred C57BL; Oxidative Stress | 2021 |
Identification of key genes and pathways and therapeutic agents in cadmium-treated liver cells: A bioinformatics study.
Topics: Apoptosis Regulatory Proteins; Cadmium; Chemical and Drug Induced Liver Injury; Computational Biology; Databases, Genetic; Early Growth Response Protein 1; Endothelin-1; Gene Expression Regulation; Gene Regulatory Networks; Humans; Hydroxyurea; Integrin alpha2; Membrane Proteins; Protein Interaction Maps; Proto-Oncogene Proteins c-fos; Signal Transduction; Small Molecule Libraries | 2017 |
Changes on serum and hepatic lipidome after a chronic cadmium exposure in Wistar rats.
Topics: Animals; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Chronic Disease; Lipids; Liver; Male; Rats; Rats, Wistar | 2017 |
Optimization, antioxidant properties and GC-MS analysis of Periploca angustifolia polysaccharides and chelation therapy on cadmium-induced toxicity in human HepG2 cells line and rat liver.
Topics: Animals; Antioxidants; Cadmium; Cadmium Chloride; Cell Survival; Cells, Cultured; Chelating Agents; Chemical and Drug Induced Liver Injury; Chemical Fractionation; Disease Models, Animal; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Hep G2 Cells; Humans; Male; Oxidative Stress; Periploca; Plant Extracts; Polysaccharides; Rats | 2018 |
Ameliorative effect of the anticancer agent salinomycin on cadmium-induced hepatotoxicity and renal dysfunction in mice.
Topics: Animals; Antineoplastic Agents; Cadmium; Chelating Agents; Chemical and Drug Induced Liver Injury; Kidney; Kidney Function Tests; Liver; Liver Function Tests; Male; Mice; Mice, Inbred ICR; Pyrans | 2018 |
Protective role of nebivolol in cadmium-induced hepatotoxicity via downregulation of oxidative stress, apoptosis and inflammatory pathways.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Apoptosis; Aspartate Aminotransferases; Cadmium; Chemical and Drug Induced Liver Injury; Down-Regulation; Liver; Male; Malondialdehyde; Nebivolol; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2018 |
Nano-encapsulation using macrocyclic carbohydrate polymers (β-cyclodextrins) of Periploca angustifolia extract: Physical stability and protective effect against cadmium-induced alterations in HepG2 cells.
Topics: Antioxidants; beta-Cyclodextrins; Cadmium; Catalase; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Glutathione; Glutathione Peroxidase; Hep G2 Cells; Humans; Lipid Peroxidation; Liver; Macrocyclic Compounds; Nanoparticles; Oxidative Stress; Periploca; Plant Extracts; Polymers; Protective Agents; Superoxide Dismutase | 2019 |
Aqueous bark extract of Terminalia arjuna protects against cadmium-induced hepatic and cardiac injuries in male Wistar rats through antioxidative mechanisms.
Topics: Acetates; Animals; Antioxidants; Biomarkers; Cadmium; Cardiotonic Agents; Chemical and Drug Induced Liver Injury; Heart Diseases; Liver; Male; Oxidative Stress; Plant Bark; Plant Extracts; Rats, Wistar; Terminalia | 2019 |
Trehalose prevents cadmium-induced hepatotoxicity by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis.
Topics: Animals; Apoptosis; Autophagic Cell Death; Cadmium; Chemical and Drug Induced Liver Injury; Liver; Male; NF-E2-Related Factor 2; Rats; Rats, Sprague-Dawley; Trehalose | 2019 |
The protective role of ascorbic acid in the hepatotoxicity of cadmium and mercury in rabbits.
Topics: Alanine Transaminase; Animals; Ascorbic Acid; Aspartate Aminotransferases; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Female; gamma-Glutamyltransferase; L-Lactate Dehydrogenase; Liver; Male; Mercuric Chloride; Mercury; Protective Agents; Rabbits | 2019 |
Extract from
Topics: Animals; Biomarkers; Cadmium; Chemical and Drug Induced Liver Injury; DNA Damage; Environmental Pollutants; Female; Fruit; Lipid Peroxidation; Oxidation-Reduction; Photinia; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Xenobiotics | 2019 |
Hepatoprotective effect of polyphenols isolated from virgin coconut oil against sub-chronic cadmium hepatotoxicity in rats is associated with improvement in antioxidant defense system.
Topics: Animals; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Coconut Oil; Dose-Response Relationship, Drug; Lipid Peroxidation; Male; Oxidative Stress; Polyphenols; Rats; Rats, Wistar | 2021 |
Differential susceptibility to cadmium-induced liver and kidney injury in wild and laboratory-bred bank voles Myodes glareolus.
Topics: Animals; Animals, Wild; Arvicolinae; Cadmium; Chemical and Drug Induced Liver Injury; Disease Susceptibility; Kidney Diseases; Male | 2013 |
Cadmium exposure and liver disease among US adults.
Topics: Adult; Cadmium; Chemical and Drug Induced Liver Injury; Environmental Exposure; Fatty Liver; Female; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Necrosis; Non-alcoholic Fatty Liver Disease; United States | 2013 |
Protective effects of blueberries (Vaccinium corymbosum L.) extract against cadmium-induced hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Anthocyanins; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Cadmium; Catalase; Chelating Agents; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Glutathione; Lipid Peroxidation; Liver; Male; Mice; Phytotherapy; Plant Extracts; Protein Carbonylation; Superoxide Dismutase; Vaccinium | 2014 |
Fenugreek seed powder mitigates cadmium-induced testicular damage and hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Hepatitis, Animal; Lipid Peroxidation; Liver Function Tests; Male; Oxidants; Plant Extracts; Rats, Wistar; Testis; Testosterone; Trigonella | 2014 |
Hepatoprotective effect of Arctium lappa root extract on cadmium toxicity in adult Wistar rats.
Topics: Alanine Transaminase; Animals; Arctium; Aspartate Aminotransferases; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Hepatocytes; Liver; Male; Phytotherapy; Plant Extracts; Plant Proteins; Plant Roots; Protective Agents; Rats, Wistar; Time Factors | 2014 |
Protective effect of olive oil and colocynth oil against cadmium-induced oxidative stress in the liver of Wistar rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Cadmium; Catalase; Chemical and Drug Induced Liver Injury; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Citrullus colocynthis; Fatty Acids; Glutathione; Lipid Peroxidation; Liver; Male; Malondialdehyde; Olive Oil; Oxidative Stress; Plant Oils; Protein Carbonylation; Rats; Rats, Wistar; Superoxide Dismutase; Vitamin A; Vitamin E | 2015 |
Acute exposure to cadmium induces prolonged neutrophilia along with delayed induction of granulocyte colony-stimulating factor in the livers of mice.
Topics: Acute Disease; Animals; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Endotoxins; Environmental Pollutants; Female; Gene Expression Regulation; Granulocyte Colony-Stimulating Factor; Kupffer Cells; Leukocytosis; Lipopolysaccharides; Liver; Mice, Inbred BALB C; Neutrophils; Systemic Inflammatory Response Syndrome; Time Factors; Tissue Distribution; Toxicokinetics | 2016 |
Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome.
Topics: Animals; Cadmium; Carrier Proteins; Cell Death; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Hepatocytes; Inflammasomes; Inflammation; Male; Melatonin; Mice; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Thioredoxins | 2017 |
The potential role of combined anti-oxidants against cadmium toxicity on liver of rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Hepatocytes; Lipid Peroxidation; Liver Diseases; Male; Metallothionein; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Selenic Acid; Selenium Compounds; Vitamin E | 2007 |
Protective effects of Chlorella vulgaris on liver toxicity in cadmium-administered rats.
Topics: Animals; Body Weight; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Chlorella vulgaris; Dietary Supplements; Hepatocytes; Hyperemia; Liver; Liver Diseases; Male; Metallothionein; Organ Size; Powders; Rats | 2008 |
Positive effects of green tea on hepatic dysfunction, lipid peroxidation and antioxidant defence depletion induced by cadmium.
Topics: Animals; Antioxidants; Biomarkers; Cadmium; Camellia sinensis; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Lipid Peroxidation; Liver Diseases; Male; Rats; Rats, Wistar; Tea | 2008 |
Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin.
Topics: Animals; Antioxidants; Biomarkers; Cadmium; Chemical and Drug Induced Liver Injury; Flavanones; Lipid Peroxidation; Liver; Male; Oxidative Stress; Rats; Rats, Wistar | 2010 |
Protective role of carnosine in mice with cadmium-induced acute hepatotoxicity.
Topics: Animals; Cadmium; Carnosine; Chemical and Drug Induced Liver Injury; Liver; Male; Mice | 2009 |
Effects of montmorillonite on alleviating dietary Cd-induced oxidative damage in carp (Carassius auratus).
Topics: Animal Feed; Animals; Antioxidants; Bentonite; Cadmium; Chemical and Drug Induced Liver Injury; Diet; Fish Diseases; Goldfish; Kidney Diseases; Malondialdehyde; Oxidative Stress; Water Pollutants, Chemical | 2011 |
Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats.
Topics: Animals; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hesperidin; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar | 2012 |
Cd/Se/Te-based quantum dot 705 modulated redox homeostasis with hepatotoxicity in mice.
Topics: Animals; Cadmium; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cytokines; Gene Expression; Immunohistochemistry; Liver; Male; Metallothionein; Mice; Mice, Inbred ICR; Oxidative Stress; Quantum Dots; Selenium; Superoxide Dismutase; Tellurium | 2011 |
Antioxidant responses, hepatic intermediary metabolism, histology and ultrastructure in Synechogobius hasta exposed to waterborne cadmium.
Topics: Animals; Antioxidants; Cadmium; Calcium; Chemical and Drug Induced Liver Injury; Gills; Hepatocytes; Lipid Peroxidation; Liver; Perciformes; Protein Carbonylation; Spleen; Water Pollutants, Chemical | 2011 |
Protective effect of zinc against cadmium hepatotoxicity depends on this bioelement intake and level of cadmium exposure: a study in a rat model.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cadmium; Chemical and Drug Induced Liver Injury; Liver; Male; Models, Animal; Necrosis; Protective Agents; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Zinc | 2011 |
Naringenin in combination with vitamins C and E potentially protects oxidative stress-mediated hepatic injury in cadmium-intoxicated rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Cadmium; Chemical and Drug Induced Liver Injury; Citrus; Drug Therapy, Combination; Flavanones; Liver; Male; Oxidative Stress; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Vitamin E; Vitis | 2011 |
Interrelationships between cadmium, zinc and antioxidants in the liver of the rat exposed orally to relatively high doses of cadmium and zinc.
Topics: Animals; Antioxidants; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Chlorides; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Zinc; Zinc Compounds | 2011 |
Effects of Origanum majorana L. on cadmium induced hepatotoxicity and nephrotoxicity in albino rats.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; Kidney Diseases; Male; Origanum; Plant Extracts; Rats | 2011 |
Bradykinin potentiating factor isolated from Buthus occitanus venom has a protective effect against cadmium-induced rat liver and kidney damage.
Topics: Animals; Biomarkers; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Kidney; Kidney Diseases; Liver; Oligopeptides; Oxidative Stress; Protective Agents; Rats; Scorpion Venoms; Scorpions | 2011 |
Antioxidant effects of heated garlic juice on cadmium-induced liver damage in rats as compared to ascorbic acid.
Topics: Administration, Oral; Animals; Antioxidants; Ascorbic Acid; Cadmium; Catalase; Chemical and Drug Induced Liver Injury; Garlic; Heme Oxygenase-1; Hot Temperature; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Male; NAD(P)H Dehydrogenase (Quinone); Plant Preparations; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase | 2011 |
Gadolinium chloride pretreatment ameliorates acute cadmium-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cadmium; Chemical and Drug Induced Liver Injury; Gadolinium; Hepatocytes; Liver; Liver Regeneration; Male; Necrosis; Peliosis Hepatis; Protective Agents; Rats; Rats, Wistar | 2013 |
Protective effects of Ganoderma lucidum spore on cadmium hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cadmium; Chemical and Drug Induced Liver Injury; Cytosol; Dose-Response Relationship, Drug; Male; Malondialdehyde; Metallothionein; Mice; Microsomes, Liver; Mitochondria, Liver; Oxidative Stress; Powders; Protective Agents; Reishi; Spores, Fungal | 2013 |
Effects of oral and intraperitoneal magnesium treatment against cadmium-induced oxidative stress in plasma of rats.
Topics: Administration, Oral; Animals; Antioxidants; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Injections, Intraperitoneal; Magnesium; Male; Oxidative Stress; Random Allocation; Rats; Rats, Wistar | 2012 |
Effects of environmental cadmium exposure on liver function in adults.
Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Cadmium; Chemical and Drug Induced Liver Injury; Cross-Sectional Studies; Environmental Exposure; Female; Humans; Linear Models; Liver; Male; Metals, Heavy; Middle Aged; Nutrition Surveys; Odds Ratio; Reference Values; Republic of Korea; Transaminases | 2013 |
Involvement of the essential metal transporter Zip14 in hepatic Cd accumulation during inflammation.
Topics: Acute-Phase Reaction; Animals; Cadmium; Cadmium Chloride; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Deficiency Diseases; Diet; Escherichia coli Infections; Gene Expression; Hexanes; Host-Pathogen Interactions; Injections, Intraperitoneal; Interleukin-6; Iron; Iron Deficiencies; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred Strains; RNA, Messenger; Turpentine; Zinc | 2013 |
Time-course of cadmium-induced acute hepatotoxicity in the rat liver: the role of apoptosis.
Topics: Acute Disease; Animals; Apoptosis; Cadmium; Chemical and Drug Induced Liver Injury; Environmental Pollutants; In Situ Nick-End Labeling; Liver; Liver Regeneration; Male; Necrosis; Rats; Rats, Wistar; Thymidine Kinase; Time Factors | 2003 |
[EFFECT OF CALCIUM COMPLEXES OF AMINOPOLYCARBOXYLIC ACIDS ON ACUTE EXPERIMENTAL CADMIUM POISONING].
Topics: Animals; Cadmium; Cadmium Poisoning; Calcium; Chelating Agents; Chemical and Drug Induced Liver Injury; Edetic Acid; Gastrointestinal Tract; Hepatitis; Humans; Kidney; Male; Mice; Pharmacology; Rats; Research; Spleen; Testis; Toxicology | 1963 |
The hepatoprotective effect of putrescine against cadmium-induced acute liver injury.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cadmium; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Liver; Liver Regeneration; Male; Necrosis; Peliosis Hepatis; Protective Agents; Putrescine; Rats; Rats, Wistar; Toxicity Tests, Acute | 2004 |
The nitric oxide donor, O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), protects against cadmium-induced hepatotoxicity in mice.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; Gene Expression; Male; Metallothionein; Mice; Nitric Oxide Donors; Pyrrolidines; Reverse Transcriptase Polymerase Chain Reaction; Subcellular Fractions | 2004 |
Strain differences of cadmium-induced hepatotoxicity in Wistar-Imamichi and Fischer 344 rats: involvement of cadmium accumulation.
Topics: Alanine Transaminase; Animals; Blood Urea Nitrogen; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Iron; Kidney; Liver; Male; Metallothionein; Rats; Rats, Inbred F344; Rats, Wistar; Species Specificity; Zinc | 2004 |
Changes in plasma hormones profile and liver function in cows naturally exposed to lead and cadmium around different industrial areas.
Topics: Animals; Cadmium; Cattle; Chemical and Drug Induced Liver Injury; Environmental Exposure; Environmental Pollutants; Estradiol; Female; Hydrocortisone; Industry; Lead; Liver; Progesterone; Thyroxine; Triiodothyronine | 2007 |
Oxidative damage in liver after perinatal intoxication with lead and/or cadmium.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Animals, Newborn; Cadmium; Cadmium Poisoning; Catalase; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; Lead; Lead Poisoning; Liver Diseases; Organ Size; Oxidative Stress; Pregnancy; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2007 |
Oral administration of diphenyl diselenide protects against cadmium-induced liver damage in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Benzene Derivatives; Bilirubin; Blood Glucose; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; gamma-Glutamyltransferase; Glycogen; Kidney; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Malondialdehyde; Organoselenium Compounds; Oxidative Stress; Porphobilinogen Synthase; Rats; Rats, Wistar; Sulfhydryl Compounds | 2008 |
Strain difference of cadmium accumulation by liver slices of inbred Wistar-Imamichi and Fischer 344 rats.
Topics: Animals; Cadmium; Carrier Proteins; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Heat-Shock Proteins; Liver; Male; Rats; Rats, Inbred F344; Rats, Wistar; Sequestosome-1 Protein; Species Specificity; Zinc | 2008 |
Effect of the flavonoid quercetin on cadmium-induced hepatotoxicity.
Topics: Animals; Biomarkers; Blotting, Northern; Blotting, Western; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Liver; Liver Function Tests; Male; Metallothionein; Nitric Oxide Synthase Type III; Oxidative Stress; Quercetin; Rats; Rats, Wistar; RNA; Thiobarbituric Acid Reactive Substances | 2008 |
Chronic hepatic and renal toxicity by cadmium in rats.
Topics: Animals; Blood Glucose; Body Weight; Cadmium; Chemical and Drug Induced Liver Injury; Diet; Fructose-Bisphosphatase; Gluconeogenesis; Glucose-6-Phosphatase; Kidney; Kidney Diseases; Liver; Male; Organ Size; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Inbred Strains; Time Factors | 1984 |
Toxicology of aflatoxin B1, warfarin, and cadmium in young pigs: clinical chemistry and blood coagulation.
Topics: Aflatoxin B1; Aflatoxins; Animal Feed; Animals; Blood Proteins; Blood Urea Nitrogen; Cadmium; Cadmium Poisoning; Carcinogens; Chemical and Drug Induced Liver Injury; Liver Diseases; Male; Swine; Swine Diseases; Warfarin | 1982 |
Cadmium toxicity in primary cultures of rat hepatocytes.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Liver; Proteins; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Urea | 1982 |
Time-dependent protective effect of selenium against cadmium-induced nephrotoxicity and hepatotoxicity.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; Female; Kidney Diseases; Liver Diseases; Rats; Selenium; Time Factors | 1982 |
Acute exposure to cadmium causes severe liver injury in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Pressure; Cadmium; Chemical and Drug Induced Liver Injury; Heart; Heart Rate; Male; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Transfer of liver cadmium to the kidney after aflatoxin induced liver damage.
Topics: Aflatoxins; Animals; Cadmium; Chemical and Drug Induced Liver Injury; Copper; Kidney; Liver; Male; Metallothionein; Rats; Zinc | 1980 |
The effect of Chinese hepatoprotective medicines on experimental liver injury in mice.
Topics: 1-Propanol; Acetaminophen; Animals; Cadmium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; Liver Diseases; Male; Mice; Mice, Inbred Strains; Propanols | 1994 |
Oleanolic acid protects against cadmium hepatotoxicity by inducing metallothionein.
Topics: Alanine Transaminase; Animals; Blotting, Northern; Cadmium; Chemical and Drug Induced Liver Injury; Cytosol; Dose-Response Relationship, Drug; Isomerism; L-Iditol 2-Dehydrogenase; Liver; Liver Diseases; Male; Metallothionein; Mice; Mice, Inbred Strains; Oleanolic Acid; Organ Size; RNA Probes; RNA, Messenger; Subcellular Fractions; Tissue Distribution | 1993 |
Ovariectomy enhances cadmium-induced nephrotoxicity and hepatotoxicity in rats.
Topics: Animals; Body Weight; Cadmium; Chemical and Drug Induced Liver Injury; Female; Immunohistochemistry; Kidney Diseases; Liver Diseases; Microscopy, Electron; Ovariectomy; Rats; Rats, Sprague-Dawley | 1993 |
Protective effects of few antioxidants on liver function in rats treated with cadmium and mercury.
Topics: Animals; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Male; Mercury; Rats | 1996 |
Sequence of exposure to cadmium and arsenic determines the extent of toxic effects in male Fischer rats.
Topics: Animals; Arsenic; Cadmium; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Interactions; Kidney Diseases; Male; Metallothionein; Necrosis; Rats; Rats, Inbred F344; Testis | 1997 |
Effects of dithiocarbamates on toxicity of cadmium in rat primary hepatocyte cultures.
Topics: Animals; Cadmium; Cadmium Poisoning; Cells, Cultured; Chelating Agents; Chemical and Drug Induced Liver Injury; Drug Interactions; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Rats; Rats, Wistar; Sorbitol; Thiocarbamates | 1997 |
Testosterone pretreatment mitigates cadmium toxicity in male C57 mice but not in C3H mice.
Topics: Animals; Antidotes; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Kidney; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Metallothionein; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Species Specificity; Testosterone; Urea | 1997 |
Tolerance induced by all-trans-retinol to the hepatotoxic effects of cadmium in rats: role of metallothionein expression.
Topics: Animals; Cadmium; Cadmium Chloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Tolerance; Injections, Intravenous; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Metallothionein; Rats; Rats, Sprague-Dawley; Testis; Tissue Distribution; Vitamin A | 1997 |
Outputs of hepatic copper and cadmium stimulated by tetrathiomolybdate (TTM) injection in Long-Evans Cinnamon (LEC) rats pretreated with cadmium, and in Fischer rats pretreated with copper and cadmium.
Topics: Animals; Bile; Cadmium; Ceruloplasmin; Chemical and Drug Induced Liver Injury; Copper; Female; Injections, Intravenous; Liver; Metallothionein; Molybdenum; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1997 |
Cadmium toxicity and distribution in metallothionein-I and -II deficient transgenic mice.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; Female; Lethal Dose 50; Liver; Liver Diseases; Male; Metallothionein; Mice; Mice, Transgenic; Oxidoreductases; Subcellular Fractions; Tissue Distribution; Zinc | 1997 |
Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cadmium; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cisplatin; Liver; Liver Diseases; Metallothionein; Mice; Mice, Knockout | 1998 |
Influence of glycine on the damage induced in isolated perfused rat liver by five hepatotoxic agents.
Topics: 1-Butanol; Adenosine Triphosphate; Alanine Transaminase; Animals; Bile; Cadmium; Chemical and Drug Induced Liver Injury; Copper; Glutathione; Glycine; L-Lactate Dehydrogenase; Liver; Male; Malondialdehyde; Oxygen Consumption; Perfusion; Peroxides; Rats; Rats, Wistar; tert-Butylhydroperoxide; Vanadates | 1998 |
Age-related change in cadmium-induced hepatotoxicity in Wistar rats: role of Kupffer cells and neutrophils.
Topics: Age Factors; Alanine Transaminase; Alkylating Agents; Animals; Anti-Inflammatory Agents; Cadmium; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Dose-Response Relationship, Drug; Escherichia coli; Gadolinium; Glutathione; Kupffer Cells; Lipopolysaccharides; Liver Diseases; Male; Metallothionein; Neutrophils; Rats; Rats, Wistar | 1998 |
Relationship between the development of hepato-renal toxicity and cadmium accumulation in rats given minimum to large amounts of cadmium chloride in the long-term: preliminary study.
Topics: Animals; Body Burden; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Diet; Female; Kidney; Kidney Diseases; Liver; Liver Diseases; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
Chronic toxic and carcinogenic effects of oral cadmium in the Noble (NBL/Cr) rat: induction of neoplastic and proliferative lesions of the adrenal, kidney, prostate, and testes.
Topics: Adrenal Gland Neoplasms; Animals; Cadmium; Carcinogenicity Tests; Carcinogens; Chemical and Drug Induced Liver Injury; Hyperplasia; Kidney Neoplasms; Male; Pheochromocytoma; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Splenic Diseases; Testicular Neoplasms | 1999 |
Attenuation of cadmium-induced liver injury in senescent male fischer 344 rats: role of metallothionein and glutathione.
Topics: Aging; Alanine Transaminase; Animals; Cadmium; Chemical and Drug Induced Liver Injury; Glutathione; L-Iditol 2-Dehydrogenase; Liver; Liver Diseases; Male; Metallothionein; Rats; Rats, Inbred F344 | 1999 |
Attenuation of cadmium-induced liver injury in senescent male fischer 344 rats: role of Kupffer cells and inflammatory cytokines.
Topics: Age Factors; Alanine Transaminase; Animals; Cadmium; Carbon; Chemical and Drug Induced Liver Injury; Chemotaxis; Cyclosporine; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Gadolinium; Inflammation Mediators; Interleukin-1; Kupffer Cells; L-Iditol 2-Dehydrogenase; Male; Neutrophil Infiltration; Phagocytosis; Rats; Rats, Inbred F344; Time Factors | 2000 |
Cadmium-induced acute hepatic injury is exacerbated in human interleukin-8 transgenic mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Humans; Interleukin-8; Kidney; Leukocyte Count; Liver; Male; Metallothionein; Mice; Mice, Inbred BALB C; Mice, Transgenic; Neutrophil Infiltration; Reverse Transcriptase Polymerase Chain Reaction; Selectins; Survival Analysis | 2000 |
Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium.
Topics: Animals; Apoptosis; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Cytosol; In Situ Nick-End Labeling; Liver; Metallothionein; Mice; Mice, Knockout; Tissue Distribution | 2000 |
Dietary cadmium induces histopathological changes despite a sufficient metallothionein level in the liver and kidneys of the bank vole (Clethrionomys glareolus).
Topics: Animals; Arvicolinae; Body Weight; Cadmium; Chemical and Drug Induced Liver Injury; Copper; Diet; Iron; Kidney; Kidney Diseases; Light; Lipid Peroxidation; Liver; Liver Diseases; Male; Metallothionein; Organ Size; Photoperiod; Zinc | 2000 |
Dexamethasone prevents acute cadmium-induced hepatic injury but exacerbates kidney dysfunction in rabbits.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Blood Urea Nitrogen; Cadmium; Chemical and Drug Induced Liver Injury; Creatinine; Dexamethasone; Disease Models, Animal; Drug Interactions; Female; Kidney; Kidney Diseases; Liver; Metallothionein; Proteinuria; Rabbits; Survival Rate; Time Factors | 2001 |
Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation.
Topics: Androgen Antagonists; Animals; Cadmium; Carrier Proteins; Cell Line; Chemical and Drug Induced Liver Injury; Cyproterone Acetate; DNA; Epithelial Cells; Glutathione; Hepatocytes; Oligonucleotide Probes; Proteins; Rats; Rats, Inbred F344 | 2001 |
Cadmium induces alpha(1)collagen (I) and metallothionein II gene and alters the antioxidant system in rat hepatic stellate cells.
Topics: Animals; Antioxidants; Blotting, Northern; Cadmium; Calcium; Catalase; Cell Line; Chemical and Drug Induced Liver Injury; Collagen Type I; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hepatocytes; Lipid Peroxidation; Liver; Metallothionein; Neutral Red; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2002 |
Glucocorticoids suppress the inflammation-mediated tolerance to acute toxicity of cadmium in mice.
Topics: Animals; Anti-Inflammatory Agents; Cadmium; Chemical and Drug Induced Liver Injury; Cytokines; Dexamethasone; Enzyme Induction; Glucocorticoids; Hemoglobins; Inflammation; Interleukin-6; Irritants; Kidney; Liver; Male; Metallothionein; Mice; Testicular Diseases; Tumor Necrosis Factor-alpha; Turpentine | 2002 |
Protective effect of selenium on certain hepatotoxic and pancreotoxic manifestations of subacute cadmium administration.
Topics: Animals; Blood Glucose; Cadmium; Chemical and Drug Induced Liver Injury; Cyclic AMP; Fructose-Bisphosphatase; Gluconeogenesis; Glucose-6-Phosphatase; Insulin; Liver; Male; Pancreatic Diseases; Phosphoenolpyruvate Carboxykinase (GTP); Pyruvate Carboxylase; Rats; Selenium; Time Factors | 1975 |
Effects of detergent formula chelating agents on the metabolism and toxicity of cadmium in mice.
Topics: Animals; Cadmium; Cadmium Poisoning; Chelating Agents; Chemical and Drug Induced Liver Injury; Detergents; Drug Synergism; Edetic Acid; Female; Liver; Male; Mice; Necrosis; Nitrilotriacetic Acid; Phosphates; Time Factors; Tissue Distribution | 1978 |
[Protective effect of cadmium acetate in trichlorobromomethane poisoning].
Topics: Acetates; Animals; Bromotrichloromethane; Cadmium; Chemical and Drug Induced Liver Injury; Chloroform; Female; Liver; Male; Rats | 1978 |
Cadmium accumulation in rat liver.
Topics: Animals; Body Weight; Cadmium; Chemical and Drug Induced Liver Injury; Chromatography, Gel; Injections, Intraperitoneal; L-Lactate Dehydrogenase; Liver; Male; Metalloproteins; Organ Size; Protein Binding; Rats; Spectrophotometry, Atomic; Subcellular Fractions | 1975 |
The effects of acute cadmium administration in the liver and kidney of the rat. Light and electron microscopic studies.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Kidney; Kidney Diseases; Kupffer Cells; Liver; Liver Diseases; Male; Rats | 1975 |
Effects of feeding and fasting on hepatolobular distribution of glutathione and cadmium-induced hepatotoxicity.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; Densitometry; Eating; Fasting; Glutathione; Histocytochemistry; Image Processing, Computer-Assisted; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Staining and Labeling | 1992 |
Cadmium-induced hepatic endothelial cell injury in inbred strains of mice.
Topics: Animals; Cadmium; Cadmium Radioisotopes; Cells, Cultured; Chemical and Drug Induced Liver Injury; Endothelium, Vascular; Liver; Male; Metallothionein; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Inbred Strains; Sensitivity and Specificity | 1992 |
Induction of metallothionein by diethyl maleate.
Topics: Animals; Base Sequence; Blotting, Northern; Cadmium; Chemical and Drug Induced Liver Injury; Cytosol; Dose-Response Relationship, Drug; Glutathione; Immunoblotting; Liver; Liver Diseases; Male; Maleates; Metallothionein; Mice; Mice, Inbred Strains; Molecular Sequence Data; Rats; Rats, Inbred Strains; RNA, Messenger; Subcellular Fractions; Time Factors; Transcription, Genetic | 1992 |
Acute exposure to cadmium causes time-dependent liver injury in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Intracellular Membranes; Kinetics; Liver; Liver Diseases; Male; Membrane Fluidity; Microsomes, Liver; Necrosis; Rats; Rats, Inbred Strains | 1991 |
The differential effects of hepatotoxicants on the sulfation pathway in rats.
Topics: 1-Naphthylisothiocyanate; 1-Propanol; Aflatoxin B1; Alanine Transaminase; Animals; Arylsulfotransferase; Bromobenzenes; Cadmium; Cadmium Chloride; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytosol; Dichloroethylenes; L-Iditol 2-Dehydrogenase; Liver; Liver Diseases; Male; Phosphoadenosine Phosphosulfate; Propanols; Rats; Rats, Inbred Strains; Sulfates; Thioacetamide | 1991 |
Investigation into the combined effects of ethanol and cadmium on rat liver and kidneys.
Topics: Alanine Transaminase; Animals; Body Weight; Brain Chemistry; Cadmium; Chemical and Drug Induced Liver Injury; Copper; Creatinine; Ethanol; Female; Kidney Diseases; L-Iditol 2-Dehydrogenase; Metallothionein; Organ Size; Polyribosomes; Protein Biosynthesis; Rats; Rats, Inbred Strains; Zinc | 1990 |
Mechanism of damage to liver cells after chronic exposure to low doses of cadmium chloride.
Topics: Animals; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Female; Histocytochemistry; Liver; Metallothionein; Nucleotidases; Rats; Rats, Inbred Strains | 1987 |
Glutathione, a first line of defense against cadmium toxicity.
Topics: 1-Propanol; Animals; Buthionine Sulfoximine; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Glutamate-Cysteine Ligase; Glutathione; Male; Metallothionein; Methionine Sulfoximine; Mice | 1987 |
Chelating-agent suppression of cadmium-induced hepatotoxicity.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Cadmium; Chelating Agents; Chemical and Drug Induced Liver Injury; Female; gamma-Glutamyltransferase; Liver; Rats; Tissue Distribution | 1987 |
Interaction of metallothionein and carbon tetrachloride on the protective effect of zinc on hepatotoxicity.
Topics: Animals; Cadmium; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytosol; In Vitro Techniques; Liver Diseases; Male; Metallothionein; Protein Binding; Rats; Rats, Inbred Strains; Zinc | 1986 |
Acetaminophen-induced hepatotoxicity: antagonistic action of caffeine in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Binding Sites; Cadmium; Caffeine; Chemical and Drug Induced Liver Injury; Fasting; Glutathione; Kidney; Male; Mice | 1987 |
Cadmium-induced hepatic and renal injury in chronically exposed rats: likely role of hepatic cadmium-metallothionein in nephrotoxicity.
Topics: Animals; Body Weight; Cadmium; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Kidney; Kidney Diseases; Liver; Liver Diseases; Male; Metallothionein; Organ Size; Rats; Rats, Inbred Strains; Tissue Distribution | 1985 |
Clinical and morphologic effects of oral cadmium toxicity in rabbits.
Topics: Anemia; Animals; Bile Ducts, Intrahepatic; Blood Cell Count; Blood Protein Disorders; Body Weight; Cadmium; Cardiomegaly; Cell Nucleus; Chemical and Drug Induced Liver Injury; Drinking Behavior; Endoplasmic Reticulum; Growth; Hematocrit; Hemoglobinometry; Kidney; Kidney Diseases; Liver; Liver Function Tests; Liver Glycogen; Lymphopenia; Male; Rabbits; Species Specificity; Splenomegaly | 1972 |
Persistence of stored Cd 2+ in the livers and kidneys of female rats during pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Cadmium; Chemical and Drug Induced Liver Injury; Female; Kidney; Kidney Diseases; Liver; Pregnancy; Pregnancy, Animal; Rats | 1972 |
[Transitory cell antigens of rat liver. I. The secretion and synthesis of fetospecific serum proteins during hepatic development and regeneration].
Topics: Aging; Amniotic Fluid; Animals; Animals, Newborn; Blood Proteins; Cadmium; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fetus; Immune Sera; Male; Methane; Pregnancy; Proteins; Radioimmunoassay; Rats; Serum Albumin; Sulfates | 1971 |
Further advances in cadmium toxicology.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; Cysteine; Humans; Kidney Diseases; Male; Rats; Selenium; Testicular Diseases; Zinc | 1970 |