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cacodylic acid and Bladder Cancer

cacodylic acid has been researched along with Bladder Cancer in 19 studies

dimethylarsinic acid : The organoarsenic compound that is arsenic acid substituted on the central arsenic atom with two methyl groups.

Research Excerpts

ExcerptRelevanceReference
"Arsenic exposure is associated with an increased risk of bladder cancer."7.75Arsenic methylation capability, myeloperoxidase and sulfotransferase genetic polymorphisms, and the stage and grade of urothelial carcinoma. ( Chen, CJ; Chiu, AW; Chung, CJ; Hsueh, YM; Huang, SK; Huang, YK; Pu, YS; Tsai, HJ; Yang, MH, 2009)
" We hypothesize that arsenic methylation ability, defined as the ratios of monomethylarsonic acid (MMA(V))/inorganic arsenic (primary arsenic methylation index, PMI) and dimethylarsinic acid (DMA(V))/ MMA(V) (secondary arsenic methylation index, SMI), may modify the association between cumulative arsenic exposure (CAE, mg/L-year) and the risk of bladder cancer."7.72Arsenic methylation and bladder cancer risk in Taiwan. ( Chen, YC; Christiani, DC; Guo, YL; Hsueh, YM; Lee, MS; Ryan, LM; Smith, TJ; Su, HJ, 2003)
"Bladder cancer has been shown to resist programmed cell death with altered expression of both pro-apoptotic and anti-apoptotic proteins."5.43Diindolylmethane and Lupeol Modulates Apoptosis and Cell Proliferation in N-Butyl-N-(4-Hydroxybutyl) Nitrosamine Initiated and Dimethylarsinic Acid Promoted rat Bladder Carcinogenesis. ( Prabhu, B; Sivakumar, A; Sundaresan, S, 2016)
" The present study aimed at comparing the toxic effect of DMMTA(V) with that of inorganic arsenite (iAs(III)) on cell viability, uptake efficiency and production of reactive oxygen species (ROS) toward human bladder cancer EJ-1 cells."5.35Evidence for toxicity differences between inorganic arsenite and thioarsenicals in human bladder cancer cells. ( Iwata, K; Le, XC; Lee, J; Naranmandura, H; Ogra, Y; Suzuki, KT; Weinfeld, M, 2009)
"Arsenic exposure is associated with an increased risk of bladder cancer."3.75Arsenic methylation capability, myeloperoxidase and sulfotransferase genetic polymorphisms, and the stage and grade of urothelial carcinoma. ( Chen, CJ; Chiu, AW; Chung, CJ; Hsueh, YM; Huang, SK; Huang, YK; Pu, YS; Tsai, HJ; Yang, MH, 2009)
"Drinking arsenic-contaminated water is associated with an increased risk of bladder cancer."3.74Trivalent arsenicals induce lipid peroxidation, protein carbonylation, and oxidative DNA damage in human urothelial cells. ( Gurr, JR; Jan, KY; Wang, AS; Wang, TC, 2007)
" We hypothesize that arsenic methylation ability, defined as the ratios of monomethylarsonic acid (MMA(V))/inorganic arsenic (primary arsenic methylation index, PMI) and dimethylarsinic acid (DMA(V))/ MMA(V) (secondary arsenic methylation index, SMI), may modify the association between cumulative arsenic exposure (CAE, mg/L-year) and the risk of bladder cancer."3.72Arsenic methylation and bladder cancer risk in Taiwan. ( Chen, YC; Christiani, DC; Guo, YL; Hsueh, YM; Lee, MS; Ryan, LM; Smith, TJ; Su, HJ, 2003)
"Bladder cancer has been shown to resist programmed cell death with altered expression of both pro-apoptotic and anti-apoptotic proteins."1.43Diindolylmethane and Lupeol Modulates Apoptosis and Cell Proliferation in N-Butyl-N-(4-Hydroxybutyl) Nitrosamine Initiated and Dimethylarsinic Acid Promoted rat Bladder Carcinogenesis. ( Prabhu, B; Sivakumar, A; Sundaresan, S, 2016)
" The present study aimed at comparing the toxic effect of DMMTA(V) with that of inorganic arsenite (iAs(III)) on cell viability, uptake efficiency and production of reactive oxygen species (ROS) toward human bladder cancer EJ-1 cells."1.35Evidence for toxicity differences between inorganic arsenite and thioarsenicals in human bladder cancer cells. ( Iwata, K; Le, XC; Lee, J; Naranmandura, H; Ogra, Y; Suzuki, KT; Weinfeld, M, 2009)
" Dose-related increases in the height of the thyroid follicular epithelium were also noted in males and females, however, such changes reflect an adaptive response of the thyroid to decreased levels of circulating thyroid hormone, rather than an adverse effect."1.33Dimethylarsinic acid: results of chronic toxicity/oncogenicity studies in F344 rats and in B6C3F1 mice. ( Arnold, LL; Cohen, SM; Eldan, M; Nyska, A; van Gemert, M, 2006)
"From weeks 97-104, urinary bladder tumors were observed in 8 of 31 and 12 of 31 rats in groups treated with 50 and 200 p."1.31Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. ( Endo, G; Fukushima, S; Iwai, S; Morimura, K; Nakae, D; Wanibuchi, H; Wei, M; Yoshida, K, 2002)
"From weeks 97 to 104, urinary bladder tumors were observed in 12 of 31, eight of 31 and none of 33 in groups 1-3, respectively."1.30Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats. ( Fukushima, S; Li, W; Wanibuchi, H; Wei, M; Yamamoto, S, 1999)
" Our objectives were to investigate the mode of action of bladder tumor formation, evaluate the dose-response and the role of diet and to determine if the urothelial effects were reversible."1.30Effects of dietary dimethylarsinic acid on the urine and urothelium of rats. ( Arnold, LL; Cano, M; Cohen, SM; Eldan, M; St John, M; van Gemert, M, 1999)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (26.32)18.2507
2000's10 (52.63)29.6817
2010's3 (15.79)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Sathua, K1
Srivastava, S1
Flora, SJS1
Lin, Z1
Shengnan, L1
Fei, W1
Yingli, S1
Qingshan, S1
Wei, S1
Shuhua, X1
Guifan, S1
Prabhu, B1
Sivakumar, A1
Sundaresan, S1
Huang, SK1
Chiu, AW1
Pu, YS2
Huang, YK3
Chung, CJ2
Tsai, HJ1
Yang, MH2
Chen, CJ2
Hsueh, YM4
Naranmandura, H1
Ogra, Y1
Iwata, K1
Lee, J1
Suzuki, KT1
Weinfeld, M1
Le, XC2
Su, CT1
Chen, HW1
Shiue, HS1
Wei, M2
Wanibuchi, H5
Morimura, K1
Iwai, S1
Yoshida, K3
Endo, G3
Nakae, D1
Fukushima, S6
Chen, YC1
Su, HJ1
Guo, YL1
Smith, TJ1
Ryan, LM1
Lee, MS1
Christiani, DC1
Arnold, LL3
Eldan, M2
Nyska, A1
van Gemert, M2
Cohen, SM3
Ohnishi, T1
Wang, TC1
Jan, KY1
Wang, AS1
Gurr, JR1
Clewell, HJ1
Thomas, RS1
Gentry, PR1
Crump, KS1
Kenyon, EM1
El-Masri, HA1
Yager, JW1
Huang, YL1
Wu, MM1
Chen, SY1
Hsu, LI1
Yamamoto, S4
Chen, H1
Hori, T1
Li, W2
Salim, EI1
Chen, T1
Na, Y1
Lee, CC1
Cano, M1
St John, M1

Reviews

1 review available for cacodylic acid and Bladder Cancer

ArticleYear
Arsenic-induced bladder cancer in an animal model.
    Toxicology and applied pharmacology, 2007, Aug-01, Volume: 222, Issue:3

    Topics: Animals; Arsenic; Arsenicals; Cacodylic Acid; Carcinogens; Disease Models, Animal; Hemoglobins; Mice

2007

Other Studies

18 other studies available for cacodylic acid and Bladder Cancer

ArticleYear
MiADMSA ameliorate arsenic induced urinary bladder carcinogenesis in vivo and in vitro.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 128

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Arsenites; Cacodylic Acid; Carcinoma,

2020
Dimethylarsinic acid (DMA(V) ) changed the expressions of proliferative related factors and secretion of inflammatory cytokines in rat bladder.
    Journal of applied toxicology : JAT, 2015, Volume: 35, Issue:2

    Topics: Animals; Cacodylic Acid; Cell Proliferation; Cyclin D1; Cyclooxygenase 2; Cytokines; Enzyme-Linked I

2015
Diindolylmethane and Lupeol Modulates Apoptosis and Cell Proliferation in N-Butyl-N-(4-Hydroxybutyl) Nitrosamine Initiated and Dimethylarsinic Acid Promoted rat Bladder Carcinogenesis.
    Pathology oncology research : POR, 2016, Volume: 22, Issue:4

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Butylhydroxybutylnitrosamine; Cacodylic Acid; Carcin

2016
Arsenic methylation capability, myeloperoxidase and sulfotransferase genetic polymorphisms, and the stage and grade of urothelial carcinoma.
    Urologia internationalis, 2009, Volume: 82, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arsenicals; Arylsulfotransferase; Cacodylic Acid; Carcinoma; Chromat

2009
Evidence for toxicity differences between inorganic arsenite and thioarsenicals in human bladder cancer cells.
    Toxicology and applied pharmacology, 2009, Jul-15, Volume: 238, Issue:2

    Topics: Aquaporins; Arsenic Poisoning; Arsenicals; Arsenites; Cacodylic Acid; Carcinogenicity Tests; Carcino

2009
Polymorphisms in one-carbon metabolism pathway genes, urinary arsenic profile, and urothelial carcinoma.
    Cancer causes & control : CCC, 2010, Volume: 21, Issue:10

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Arsenic; Cacodylic Acid; Carcinoma,

2010
Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors.
    Carcinogenesis, 2002, Volume: 23, Issue:8

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; beta Catenin; Cacodylic Acid; Carcinogens; Cytoskeletal Protei

2002
Arsenic methylation and bladder cancer risk in Taiwan.
    Cancer causes & control : CCC, 2003, Volume: 14, Issue:4

    Topics: Aged; Arsenicals; Cacodylic Acid; Carcinoma, Transitional Cell; Case-Control Studies; Female; Humans

2003
Dimethylarsinic acid: results of chronic toxicity/oncogenicity studies in F344 rats and in B6C3F1 mice.
    Toxicology, 2006, Jun-01, Volume: 223, Issue:1-2

    Topics: Administration, Oral; Animals; Cacodylic Acid; Carcinogens; Dose-Response Relationship, Drug; Female

2006
Trivalent arsenicals induce lipid peroxidation, protein carbonylation, and oxidative DNA damage in human urothelial cells.
    Mutation research, 2007, Feb-03, Volume: 615, Issue:1-2

    Topics: Arsenic Poisoning; Arsenicals; Cacodylic Acid; Cell Line; DNA Damage; Glutathione; Humans; Lipid Per

2007
Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report.
    Toxicology and applied pharmacology, 2007, Aug-01, Volume: 222, Issue:3

    Topics: Animals; Arsenic; Arsenicals; Cacodylic Acid; Carcinogens; Cell Proliferation; DNA; DNA Repair; Dose

2007
Arsenic exposure, urinary arsenic speciation, and the incidence of urothelial carcinoma: a twelve-year follow-up study.
    Cancer causes & control : CCC, 2008, Volume: 19, Issue:8

    Topics: Adult; Aged; Arsenic; Arsenic Poisoning; Arsenicals; Cacodylic Acid; Carcinoma, Transitional Cell; C

2008
Promoting effects of dimethylarsinic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in rats.
    Carcinogenesis, 1996, Volume: 17, Issue:11

    Topics: Animals; Bromodeoxyuridine; Butylhydroxybutylnitrosamine; Cacodylic Acid; Carcinogens; Cell Division

1996
Promotion of NCI-Black-Reiter male rat bladder carcinogenesis by dimethylarsinic acid an organic arsenic compound.
    Cancer letters, 1998, Dec-11, Volume: 134, Issue:1

    Topics: Alpha-Globulins; Animals; Butylhydroxybutylnitrosamine; Cacodylic Acid; Carcinogenicity Tests; DNA,

1998
Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats.
    Carcinogenesis, 1999, Volume: 20, Issue:9

    Topics: Administration, Oral; Animals; Cacodylic Acid; Carcinogenicity Tests; Carcinoma, Transitional Cell;

1999
Loss of heterozygosity in (LewisxF344)F1 rat urinary bladder tumors induced with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by dimethylarsinic acid or sodium L-ascorbate.
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:8

    Topics: Animals; Ascorbic Acid; Butylhydroxybutylnitrosamine; Cacodylic Acid; Carcinogenicity Tests; Carcino

1999
Effects of dietary dimethylarsinic acid on the urine and urothelium of rats.
    Carcinogenesis, 1999, Volume: 20, Issue:11

    Topics: Animals; Body Weight; Bromodeoxyuridine; Cacodylic Acid; Diet; Drinking Behavior; Feeding Behavior;

1999
Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.
    Mutation research, 2001, Jun-02, Volume: 477, Issue:1-2

    Topics: Animals; Butylhydroxybutylnitrosamine; Cacodylic Acid; Carcinogens; Cell Division; Cell Transformati

2001