c-peptide and Uterine-Neoplasms

A total of 97 patients suffering from endometrial polyposis, hyperplasia, adenomatous hyperplasia, and carcinoma were examined. The levels of malonic dialdehyde as an index of lipid peroxidation, average-mass molecules, C peptide, humoral immunity parameters were studied. The content of circulating immune complexes were also determined. Specific changes which might be an auxiliary factor in predicting the therapy and forming cancer risk groups were identified.

Topics: C-Peptide; Endometrial Hyperplasia; Female; Humans; Lipid Peroxidation; Malondialdehyde; Molecular Weight; Risk Factors; Toxins, Biological; Uterine Neoplasms

Inasmuch as the elevated levels of substance(s) immunologically cross-reactive with insulin (SICRI) in a diabetic woman with carcinoma of the corpus uteri decreased following the surgical removal of the uterus and ovaries, 80 women with cervical carcinomas of various stages and 70 women with carcinomas of the corpus uteri of various stages were screened for the levels of SICRI and C-peptide. The levels of SICRI in the second, third, and fourth stages of the cancers were elevated (up to six times above the normal levels of immunoreactive insulin) and stage-dependent. The levels of C-peptide, which are related to the insulin-secreting activity of pancreatic beta-cells, were normal and independent of the stage of cancer.

Topics: Adenocarcinoma; Aged; Blood Glucose; C-Peptide; Cross Reactions; Diabetes Complications; Diabetes Mellitus; Female; Humans; Insulin; Neoplasm Staging; Probability; Radioimmunoassay; Uterine Cervical Neoplasms; Uterine Neoplasms