c-peptide and Uterine-Cervical-Neoplasms

Topics: Adult; C-Peptide; Carcinoma, Small Cell; Fatal Outcome; Female; Glucose; Humans; Hypoglycemia; Insulin; Insulin Secretion; Proinsulin; Uterine Cervical Neoplasms

A radionuclide study of liver, small intestine function and a radioimmunoassay to determine the level of insulin, C-peptide and gastrin in the blood were performed in 177 patients with cervical cancer before and during radiation therapy and in 77 healthy women. Combined radiotherapy of cervical cancer was shown to result in disorder of absorptive-excretory function of the liver, disturbed fat assimilation in the small intestine and a decrease in gastrin production. Hyperfunction of the pancreas endocrine apparatus was noted in the cervical cancer patients, and radiation therapy caused the suppression of insulin production.

Topics: C-Peptide; Female; Gastrins; Humans; Insulin; Intestine, Small; Liver; Radionuclide Imaging; Radiotherapy; Uterine Cervical Neoplasms

Topics: C-Peptide; Female; Gastrins; Glucagon; Humans; Insulin; Radioimmunoassay; Trypsin; Uterine Cervical Neoplasms

Insulin and C-peptide levels were studied with a radioimmunoassay in the peripheral blood serum of 44 patients with gastric and cervical cancer and 22 healthy persons. Hyperfunction of the pancreatic insular apparatus was shown in cancer patients which was expressed in a statistically significant increase in the C-peptide level. In gastric cancer patients hyperfunction of the insular apparatus was accompanied by hypoinsulinemia, and in cervical cancer patients by hormoinsulinemia. However an analysis has shown that the ratio insulin/C-peptide in gastric and cervical cancer patients was about the same and significantly lower than the control. A conclusion has been made that in spite of difference in the initial insulin concentration, the same phenomenon--acceleration of the metabolic clearance of insulin--occurs in patients with cancer of the above sites. As a result of treatment irrespective of its modality the reverse development of changes revealed before treatment took place. The C-peptide level decreased, the ratio insulin/C-peptide increased, i.e. hyperfunction of the insular apparatus disappeared and the metabolic clearance of insulin slowed down.

Topics: C-Peptide; Female; Humans; Insulin; Peptides; Stomach Neoplasms; Uterine Cervical Neoplasms

Inasmuch as the elevated levels of substance(s) immunologically cross-reactive with insulin (SICRI) in a diabetic woman with carcinoma of the corpus uteri decreased following the surgical removal of the uterus and ovaries, 80 women with cervical carcinomas of various stages and 70 women with carcinomas of the corpus uteri of various stages were screened for the levels of SICRI and C-peptide. The levels of SICRI in the second, third, and fourth stages of the cancers were elevated (up to six times above the normal levels of immunoreactive insulin) and stage-dependent. The levels of C-peptide, which are related to the insulin-secreting activity of pancreatic beta-cells, were normal and independent of the stage of cancer.

Topics: Adenocarcinoma; Aged; Blood Glucose; C-Peptide; Cross Reactions; Diabetes Complications; Diabetes Mellitus; Female; Humans; Insulin; Neoplasm Staging; Probability; Radioimmunoassay; Uterine Cervical Neoplasms; Uterine Neoplasms