c-peptide and Stomach-Ulcer

The aim of the study was to investigate whether oral application of misoprostol (MI), which is an analogue of prostaglandin E1, does change the secretion of insulin and the blood glucose level. The investigations were carried out in 15 subjects, aged 21-40 yrs, with a gastric or duodenal ulcer and without any disturbances of the digestive tract motility. In 7 of them (group A), without stated diabetes a single oral dose of 400 mg MI versus placebo (PL) and 15 min later 75 g glucose p.o., was applied in randomized order, on different days, in fasting state. In 8 subjects with mild diabetes type II (gr B) MI versus PL and after 15 min. i.v. 1.0 mg glucagon was similarly administered. In both groups the concentrations of glucose and C-peptide in blood were determined. In comparison to PL, the application of MI did not cause any statistically significant differences of C-peptide in serum and blood glucose levels neither before and after oral glucose loading nor after i.v. administration of glucagon. Statistically not significant were also the differences in AUC (p > 0.05).

Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Duodenal Ulcer; Glucagon; Humans; Male; Misoprostol; Radioimmunoassay; Stomach Ulcer

The effect of vagotomy and gastric resection on insulin secretion was examined by the glucagon stimulated C-peptide test in gastrectomy patients (n = 11) without truncal vagotomy and in total gastrectomy patients (n = 10) with truncal vagotomy. The test was performed twice in each patient: 10 minutes after the midline incision was made and then 60 to 90 minutes later when gastric resection or total gastrectomy was completed, during the reconstructive phase of the operation. Gastric resection without truncal vagotomy was followed by a higher increase (48%) in serum C-peptide concentration caused by glucagon stimulation than total gastrectomy with truncal vagotomy (13%). There was a significant (p less than 0.05) increase in the glucagon stimulated glucose-related C-peptide concentration in patients without truncal vagotomy, whereas truncal vagotomy inhibited this increase. These results suggest that truncal vagotomy will produce a reduction in stimulated insulin secretion in humans.

Topics: Adult; Aged; Blood Glucose; C-Peptide; Female; Gastrectomy; Glucagon; Humans; Insulin; Insulin Secretion; Intraoperative Period; Male; Middle Aged; Pancreas; Secretory Rate; Stomach Neoplasms; Stomach Ulcer; Time Factors; Vagotomy, Truncal

Topics: Adolescent; Adult; Aged; C-Peptide; Cyclic AMP; Duodenal Ulcer; Female; Gastric Acid; Gastrins; Glucagon; Humans; Insulin; Male; Middle Aged; Pancreatic Hormones; Stomach Ulcer