c-peptide and Protein-Aggregation--Pathological

Over the last 20 years, proinsulin C-peptide emerged as an important player in various biological events. Much time and effort has been spent in exploring all functional features of C-peptide and recording its implications in Diabetes mellitus. Only a few studies, though, have addressed C-peptide oligomerization and link this procedure with Diabetes. The aim of our work was to examine the aggregation propensity of C-peptide, utilizing Transmission Electron Microscopy, Congo Red staining, ATR-FTIR, and X-ray fiber diffraction at a 10 mg ml

Topics: Amino Acid Sequence; Amyloid; C-Peptide; Congo Red; Diabetes Mellitus; Humans; Insulin; Microscopy, Electron, Transmission; Microscopy, Polarization; Microscopy, Video; Protein Aggregation, Pathological; Protein Conformation; Protein Multimerization; Spectroscopy, Fourier Transform Infrared; Staining and Labeling; X-Ray Diffraction