c-peptide and Pain--Intractable

Chronic pancreatitis (CP) in children is associated with significant morbidity and can lead to narcotic dependence. Total pancreatectomy (TP) may be indicated in refractory CP to relieve pain; simultaneous islet autotransplant (IAT) may prevent postsurgical diabetes. About half of pediatric patients are insulin independent 1 yr after IAT. Insulin independence correlates best with the number of islets available for transplantation (islet yield). Currently there is no known method to predict islet yield in a given patient. We assessed the ability of preoperative metabolic tests to predict islet yields in 10 children undergoing TP/IAT.. Hemoglobin A1c (HbA(1c)) and mixed meal tolerance tests (MMTT) were obtained prior to surgery in 10 patients age

Topics: Adolescent; Blood Glucose; C-Peptide; Carrier Proteins; Child; Child, Preschool; Creatinine; Cystic Fibrosis Transmembrane Conductance Regulator; Diabetes Mellitus, Type 1; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Pain, Intractable; Pancreatectomy; Pancreatitis, Chronic; Prospective Studies; Transplantation, Autologous; Treatment Outcome; Trypsin; Trypsin Inhibitor, Kazal Pancreatic